Abstract: The present invention relates to Lrig1 (leucine-rich and immunoglobulin-like domains 1) protein, a cell surface antigen specifically present on the surface of immune cells, and various uses thereof.

Abstract: The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method of culturing stem cells in a medium containing a sialyloligosaccharide, a method of augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition including the stem cells as an active ingredient. The composition or the method according to one or more embodiments may suppress the aging of stem cells and may maintain and augment stemness.

Abstract: Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.

Abstract: Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease characterized by the progressive loss of motor neurons. Muse cells are endogenous reparative pluripotent-like stem cells distributed to various tissues. Once intravenously injected, such cells, upon sensing sphingosine-1-phosphate produced by damaged cells, settle selectively on damaged sites, and after homing, can exhibit multiphase effects including natural differentiation into tissue-protecting and tissue-reconstructing cells. In the present invention, with G93A-Tg mice serving as an ALS model, human Muse cells injected intravenously successfully homed into the lumbar cord, mainly at the pia mater and the lower white matter, and expressed glial-like forms and GFAP. Meanwhile, no such homing or differentiation was observed in the case of human mesenchymal stem cells (MSCs), and, rather, MSCs were found distributed to the lungs.

Abstract: The present disclosure provides a method for preparing a platelet lysate for use in the culture of cells collected from an individual. More specifically, the present disclosure provides a method for preparing a platelet lysate for use in the culture of cells collected from an individual, in which the method includes a step for freeze-thawing platelets collected from the individual or an equivalent of the platelets to produce a platelet lysate, and does not include a step for carrying out decomplementation. In some embodiments, the platelets or the equivalent thereof may be freeze-thawed one or several times.

Abstract: Embodiments of the disclosure include methods and compositions for treatment or reduction in risk of coagulopathy of any kind, including associated with inflammation. In specific embodiments, the coagulopathy is associated with upregulated production of tissue factor in the individual. In specific embodiments, the coagulopathy is in an individual that has SARS-CoV-2 infection or is at risk for having SARS-CoV-2 infection. In specific embodiments, the methods and compositions include fibroblasts, and/or modified fibroblasts, and/or derivatives of fibroblasts, including those fibroblasts exposed to TNF-alpha or one or more other inflammatory agents before activation of the fibroblasts.

Abstract: Dosage units consist of an autologous cell therapy product composed of fibroblasts grown for each individual to be treated. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own skin using current good manufacturing practices (CGMP), and standard tissue culture procedures, is supplied in vials containing cryopreserved fibroblasts or precursors thereof, having a purity of at least 98% fibroblasts and a viability of at least 85%, for administration of from one to six mL, preferably two mL, of cells at a concentration of from 1.0-2.0×107 cells/mL. When injected into the nasolabial fold wrinkles (creases on the sides of the nose that extend to the corners of the mouth), the autologous fibroblasts are thought to increase the synthesis of extracellular matrix components, including collagen, reducing the severity of these wrinkles. Dosage and timing of administration have been demonstrated to be critical to achieving clinically significant outcomes.

Abstract: Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.

Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: Methods of facilitating the administration of ammonia oxidizing microorganisms (AOM) to the surface of a subject are disclosed. The methods include providing a container comprising an AOM preparation suitable to administration of the subject. Containers comprising an AOM preparation suitable for administration to the subject are also disclosed.

Abstract: The present invention relates to a novel isolated and characterised bacterial strain belonging to the species Lacticas- eibacillus rhamnosus, to compositions thereof and to the use thereof in the treatment of genitourinary infections and/or inflammations

Abstract: The present invention relates to a composition or to a kit of compositions comprising Bifidobacterium longum subsp longum and Lacto-N-tetraose (LNT) for use in increasing microbiota activity, for improving engraftment and/or survival of Bifidobacteria, such as B. longum subsp. longum, for promoting the growth of beneficial bacteria in the gut, such as for promoting the growth of Streptococcus salivarius, for treating and/or preventing inflammatory conditions in the gut, for preventing and/or treating infections, for improving immunity and/or for improving oral health.

Abstract: The invention relates to biomaterials, which comprise a bacterial cellulose matrix and probiotics entrapped in said bacterial cellulose. The invention also relates to methods for obtaining the biomaterial, as well as uses of the biomaterial in medicine. It also relates to coated food products wherein the coat is composed of said biomaterial wherein the coat acts to prevent the proliferation of undesired bacteria. It also relates to packaged medical devices, wherein the package comprises said biomaterial also preventing growth of pathogenic bacteria.

Abstract: Disclosed are probiotic compositions including: one or more strains belonging to the genus Lactobacillus selected from the species: Lactobacillus plantarum and Lactobacillus acidophilus; and one or more strains belonging to the genus Bifidobacterium selected from the species: Bifidobacterium lactis, Bifidobacterium infantis and Bifidobacterium longum. The compositions include: at least one strain of Lactobacillus plantarum and at least one strain of Bifidobacterium lactis; and at least two strains belonging to the genus Lactobacillus or to the genus Bifidobacterium as defined above. Also disclosed are methods to modulate immune systems using such compositions.

Abstract: An antibacterial formulation having a mixture of bacteriophages with lytic activity against strains of Salmonella spp. and a pharmaceutically and veterinarily acceptable vehicle, pH stabilizer and/or excipients. This formulation is for the prevention and treatment of infectious diseases caused by Salmonella spp. and different serovars; use and method for preventing or treating infectious diseases caused by Salmonella spp. in farm animals by administering the antibacterial formulation to a non-human animal orally.

Abstract: Pharmaceutical compositions are described comprising fucoidan for use in a method for the treatment or the prevention, by intranasal administration, of coronavirus infection in a human. Particularly, the viral infection is OC43 or SARS-CoV-1 or SARS-CoV-2 infection. There are also described Pharmaceutical compositions comprising fucoidan for use in a method for prevention coronavirus spread in a human population, wherein subjects of the population are tested for infection with OC43 or SARS-CoV-1 or SARS-CoV-2 and infected subjects are treated with intranasal administration of the Pharmaceutical composition.

Abstract: An example composite material for a medical apparatus includes a matrix material, and a cannabis phase disposed in the matrix material. The cannabis phase includes at least one active chemical. A medical apparatus and a method of making a medical apparatus are also disclosed.

Abstract: The invention relates to an anti-hypercholesterolemia composition and a method of manufacturing the composition. Accordingly, the present invention discloses the composition to lower the cholesterol formation and a method of manufacturing the same. The anti-hypercholesterolemia composition comprises Basella alba leaf extract in the range of 30 to 70 wt %, red yeast rice extract in the range of 5 to 50 wt %, squalene extract in the range of 1 to 30 wt %, Cordyceps extract in the range of 10 to 70 wt % and at least one nutraceutically or pharmaceutically acceptable excipient in the range of 0.01 to 50 wt %.

Abstract: The present invention related to a composition comprising an extract of alder tree or the isolated compounds therefrom for treating and preventing skeleton muscle disease and the use thereof.

Abstract: The invention relates to a THC-free cannabinoid concentrate, method of obtaining the same and use thereof. The method of obtaining comprises an alkaline wash to purify lipid extracts.

Abstract: Embodiments of the invention are directed to compositions containing cannabinoid, cannabidiol, cannabidiol isomer, or cannabidiol analog and combinations thereof for treating microbial infections, and methods for treating microbial infections by topically administering compositions containing cannabinoid, cannabidiol, or cannabidiol analog to the patient in need of treatment.

Abstract: The invention relates to a pharmaceutical composition comprising a Cannabis extract and optionally one or more pharmaceutically acceptable carriers, diluents, adjuvants, excipients or any combination thereof, the Cannabis extract comprising a cannabinoid fraction comprising ?9-Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Cannabinol (CBN) and a terpene fraction in an amount of at least 3% by weight of the extract. The invention also relates to methods of treating sleep disorders using this pharmaceutical composition.

Abstract: Veterinary compositions including an essential oil such as anise oil, cinnamon oil, tarragon oil, clove oil, dill oil, Balsam of Peru, Ballota oil, star anise oil, and/or calamus oil are disclosed. The essential oil may be present in the form of a complex with a mixture of organic acids such as four of valeric acid, isovaleric acid, lactic acid, butyric acid, acetic acid, propionic acid, formic acid, benzoic acid, pelargonic acid, salicylic acid, malonic acid, citric acid, phthalic acid, tartaric acid, oxalic acid, malic acid, shikimic acid, fumaric acid, mandelic acid, cinnamic or derivatives thereof and a metal such as molybdenum, cobalt, nickel, chromium, zinc, bismuth, copper, manganese, selenium, iron, and/or their salts or oxides. The compositions may be used for the treatment and/or prevention of protozoan diseases in animals. Methods of manufacturing the veterinary compositions are also disclosed.

Abstract: Veterinary compositions comprising an essential oil such as parsley seed oil, lovage seed oil, and/or celery seed oil are disclosed. The essential oil is present in the form of a complex with a mixture of organic acids such as four acids of valeric acid, isovaleric acid, lactic acid, butyric acid, acetic acid, propionic acid, formic acid, benzoic acid, pelargonic acid, salicylic acid, malonic acid, citric acid, phthalic acid, tartaric acid, oxalic acid, malic acid, shikimic acid, fumaric acid, mandelic acid, cinnamic acid or derivatives thereof and a metal such as iron, bismuth, zinc, copper, manganese, cobalt, molybdenum, chromium, silver, gold, platinum, tungsten, germanium, tin, strontium, antimony, or salts or oxides thereof. The composition may be for the treatment and/or prevention of diseases caused by protozoa in animals. Methods of manufacturing the veterinary compositions are also disclosed.

Abstract: The present invention relates to a composition for the prevention or treatment of respiratory diseases containing an Agastache rugosa and licorice extract as an active ingredient, and more specifically, the present invention relates to a composition for the prevention or treatment of respiratory diseases caused by fine dust containing an extract, in which Agastache rugosa and licorice are mixed at a weight ratio of 1:1 to 6:1, as an active ingredient. The Agastache rugosa and licorice extract of the present invention has the efficacies of reducing cough through inhibition of TRPV1 activity, reducing lung inflammation through inhibition of CXCR1 and CXCR2 activities and GR-1+CD11b+ cell ratio reduction, and suppressing sputum production through inhibition of MUC5AC activity.

Abstract: The disclosure concerns a composition for strengthening the immunity system to acquire pan-immunity, for the prevention and treatments of infectious and other diseases with immunological components, including eliminating cancer cells. The administration of the composition can be by oral, parenteral or non-parenteral routes, local injection, topical application, or in combinations thereof, and the administration of the composition as adjuvant potentiator in various therapies/treatments uses the aforenamed routes. The composition contains, as active ingredients, an extract of Allium species and an extract of Citrus species and an extract of Paullinia species and an extract of Theobroma species.

Abstract: A method for treating coronavirus infection and bacterial infection in a subject in need thereof, including: applying to the subject a topical solution containing a therapeutically effective amount of Phyllanthus urinaria (PU) extract or one of its physiologically acceptable forms; and administering to the subject a composition comprising a therapeutically effective amount of Houttuynia cordata (HC) extract or one of its physiologically acceptable forms.

Abstract: By combining temozolomide with a mutant IDH1 enzyme inhibitor, it was discovered that the dosage of temozolomide could be reduced without decreasing the antitumor effect, enabling us to provide a combination drug with excellent efficacy against cancers with IDH1 mutations.

Abstract: The present invention relates to a peptide SSTP1 that modulates IL6 pathway to induce apoptosis in cells where there is overexpression of IL6R? (Interleukin 6 Receptor). This is achieved by inhibiting IL6/JAK/STAT pathway and/or by activating JNK/AP1 signal transduction pathway. The sensitivity of the cancer cells to SSTP1 was proportional to IL6R? levels. Further, SSTP1 kills triple negative breast cancer cells, MDA-MB-231, at a concentration that cause neither hemolysis nor cell death to blood cells. The peptide of the present invention utilizes the elements of IL6 pathway and induces apoptosis in cancer cells. SSTP1 functions by activation of JNK/AP1 pathway with concomitant inhibition of STATs, offering a new therapeutic strategy to treat cancer cells that overexpress IL6R?.

Abstract: Acute myelogenous leukaemia (AML) often bear a mutation in the NPM1 nucleolar chaperone, but the transforming properties of the NPM1c oncoprotein remain incompletely understood. Here the inventors show that NPM1c binding to PML, a key senescence gene, disrupts PML nuclear bodies (NB) yielding proliferation, mitochondrial alterations and intracellular stress. Actinomycin-D (ActD), an anticancer antibiotic with clinical efficacy in NPM1c-AMLs, targets these dysfunctional mitochondria to induce ROS. The later disrupt disulphide-linked NPM1c/PML complex, restoring PML NBs and initiating senescence. An ActD-responsive patient displayed features of mitochondria-initiated senescence. These studies highlight unexpected mitochondrial involvement both downstream of the NPM1c/PML axis and as a key feature of ActD therapy.

Abstract: The present disclosure relates to methods of inhibiting vimentin activity, methods of screening for new vimentin inhibitors and uses of new vimentin inhibitors.

Abstract: The present application relates to a method of treating a subject having a condition mediated by a deficiency in myelin. This method involves selecting a subject having a condition mediated by a deficiency in myelin and expressing a transcription factor 7-like 2 (TCF7L2) protein in the selected subject under conditions effective to treat the condition. Also disclosed is a method of increasing oligodendrocyte production from glial progenitor cells. This method involves providing a population of glial progenitor cells and expressing a TCF7L2 protein in the provided population of glial progenitor cells under conditions effective to increase oligodendrocyte production compared to oligodendrocyte production absent said administering. Also disclosed is a genetic construct suitable, inter alia, for carrying out these methods.

Abstract: Formulated and/or co-formulated liposomes comprising TLR prodrugs and/or TLR Lipid Moieties and methods of making the liposomes are disclosed herein. The TLR prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit Toll-Like Receptor (e.g., TLR1/2, TLR4, and/or TLR7). The TLR prodrugs can be formulated and/or co-formulated into a liposome to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.

Abstract: Provided herein is the use of a soluble form of a member of the CD83 family of proteins (sCD83) for wound healing, including hard-to-heal wounds of elderly, diabetic, or patients under immunosuppressant medication. Further provided is the therapeutic use of the sCD83 for the systemic promotion of hair growth, after physical stress/medication, disease and/or depilation by application of systemic sCD83, and cosmetic methods for skin and hair care comprising the topical application of sCD83.

Abstract: In certain aspects, the present disclosure provides dosing regimens, dosing forms, and formulations comprising a recombinant fusion protein comprising human activin receptor type-II (ActRII) polypeptides or derivatives thereof linked to a constant domain of an immunoglobulin, such as human IgG1 Fc domain. The disclosure also provides kits and methods for using such formulations to treat a human subject with a thalassemia or myelodysplastic syndromes (MDS).

Abstract: This disclosure provides a method of preventing, alleviating or treating a condition (i.e., neutropenia) in a subject in need thereof, the condition characterized by compromised white blood cell production in the subject. The method includes administering to the subject a therapeutically effective amount of a protein complex on the same day as a chemotherapy regimen, wherein the protein complex is a modified human granulocyte-colony stimulating factor (hG-CSF) covalently linked to an immunoglobulin Fc region via a non-peptidyl polymer. The non-peptidyl polymer is site-specifically linked to an N-terminus of the immunoglobulin Fc region, and the modified hG-CSF comprises substitutions in at least one of Cys17 and Pro65.

Abstract: Provided are IL-15 variants and heterodimeric IL-15/IL-15R?-Fc fusion proteins comprising the IL-15 variants, the methods of producing the same and the uses thereof. The IL-15 variants and fusion proteins of provided can be used as a potent agent for the treatment of cancers.

Abstract: The present invention relates to the field of biomedicine. Disclosed herein is interferon-based method and pharmaceutical combination for treating cancer. In particular, the present invention relates to an interferon-based method for treating cancer, comprising i) intermittently administering an interferon-based therapeutic agent, and ii) administering an additional anticancer agent, preferably, Gemcitabine, to a subject. The present invention also relates to a pharmaceutical combination for use in said method.

Abstract: The stapled peptides of the present invention, and pharmaceutically acceptable salts thereof, are co-agonists of the glucagon and GLP-1 receptors, and may be useful in the treatment, prevention and suppression of diseases mediated by the glucagon receptor and the GLP-1 receptor, including but not limited to, metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.

Abstract: The present invention refers to a pharmaceutical preparation comprising liraglutide or gefitinib or a salt, solvate or combination thereof, in an effective amount for use in prophylactic or therapeutic treatment of a disease condition which is caused by or associated with an infection by a coronavirus.

Abstract: Products, systems and methods are disclosed for lowering the concentrations of at least one of preservatives and fibrils in a liquid insulin composition. One method comprises replacing at least a portion of at least one of phenol and m-cresol with at least one of cyclodextrins, cyclodextrin polymers, cyclodextrin beads, and an ion exchange resin.

Abstract: A composition is described for the treatment of infections caused by pathogens, such as viruses, bacteria, fungi or yeasts. In particular, the composition of the invention comprises a synergistic association of i) active ingredient comprising lactoferrin or at least one peptide comprising lactoferricin, polylysin, natamycin or their mixture, or a mixture of lactoferrin and said at least one peptide, and ii) at least one plant extract comprising antioxidants selected from catechins, polyphenols and their mixtures. This synergistic association has been shown to be significantly active against these pathogens.

Abstract: This invention relates to improved uses of botulinum neurotoxins in the treatment of sialorrhea or diseases or conditions relating to increased saliva production. In particular are botulinum neurotoxins disclosed which are administered into parotid and submandibular glands in a dose ratio between 1.45 to 1 and 1.7 to 1.

Abstract: This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption from orally administered antibiotics.

Abstract: Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient.

Abstract: Provided herein are MAGEA1 immunogenic peptides, binding proteins recognizing MAGEA1 immunogenic peptides, and uses thereof.

Abstract: Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

Abstract: The present disclosure provides fusion proteins comprising Mycobacterium tuberculosis (Mtb) antigens, nucleic acid molecules encoding the same, vectors comprising nucleic acid molecules, compositions comprising the same, and methods of eliciting an immune response against tuberculosis.

Abstract: An immunogenic composition comprising bacterial membrane vesicles (MVs) comprising a streptococcal MalX antigen and/or a streptococcal PrsA antigen, characterized in that the MVs do not comprise an immunogenic amount of a streptococcal PspA antigen. The membrane vesicles may be artificial membrane particles. Medical uses of the composition in particular for immunization against pneumococcal disease, and methods of manufacturing the composition.

Abstract: The disclosure relates to Lassa virus, Nipah virus, and betacoronavirus ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.