Abstract: A device for the uninterrupted administration of fluid to an animal body during a draw of bodily fluid, e.g., blood, is disclosed. A first fluid channel is configured to selectively transport IV fluid to an animal body and to draw a bodily fluid from the body. A sealing member for sealing a bodily fluid draw port defines a concave surface on a first end. The sealing member concave surface forms an interior surface portion of the first fluid channel. A connection member is configured to connect to a catheter to the first fluid channel and defines a concave distal end. A second fluid channel continuously provides IV fluid to a lumen coaxially located within the catheter. The concave surface and the concave distal end are shaped to create fluid flow patterns that quickly and completely remove residual bodily fluid remaining after a draw of bodily fluid is completed.

Abstract: To detect air in a fluid delivery line of an infusion system, infusion fluid is pumped through a fluid delivery line adjacent to at least one sensor. A signal is transmitted and received using the at least one sensor into and from the fluid delivery line. The at least one sensor is operated, using at least one processor, at a modified frequency which is different than a resonant frequency of the at least one sensor to reduce an amplitude of an output of the signal transmitted from the at least one sensor to a level which is lower than a saturation level of the analog-to-digital converter to avoid over-saturating the analog-to-digital converter. The signal received by the at least one sensor is converted from analog to digital using an analog-to-digital converter. The at least one processor determines whether air is in the fluid delivery line based on the converted digital signal.

Abstract: A system includes a drug injection device including a distal end and a proximal end that includes a syringe for injecting a drug into a patient's body. The system further includes an electronic module for wirelessly exchanging data related to a usage of the drug injection device with a device paired with the electronic module, the electronic module being attached to or integrated in the distal end of the drug injection device; a computing device configurable for a pairing with the electronic module for wireless exchange of the data and including a touch interface; a touch input means for providing inputs on the touch interface, the touch input means attached to the drug injection device; and a computer program including instructions for execution by a processor of the computing device to configure the computing device for the pairing with the electronic module based on the inputs received via the touch interface.

Abstract: The disclosure relates to a method which includes i) prompting input of: a creatinine clearance (CrCl) of a subject; an amount of an oral or IV maintenance dosage of dofetilide for the subject; and optionally a projected start time for dofetilide infusion; and ii) executing computer executable instructions to derive from a set of rules a dofetilide dosing protocol for the subject based on the inputs. The disclosure also relates to systems and medical devices configured to perform one or more steps of the method, as well as a non-transitory computer-readable storage medium comprising computer-executable instructions or software stored thereon capable of performing one or more steps of the method.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: A drug delivery device includes a housing, a blocking feature rotationally secured relative to the housing, a drive unit, a rod operatively coupled to the drive unit and arranged to move distally relative to the housing when the rod is released, and a movable trigger member. The rod is rotatable relative to the housing and has an unprimed state and a primed state. In the unprimed state, the blocking feature is arranged to block a rotation of the rod into the release position, and in the primed state, a trigger member feature is arranged to block rotation of the rod into the release position. The trigger member is arranged to move relative to the housing to release the rod. To switch from the unprimed state into the primed state, the trigger member moves and a movement is converted into an axial movement of the rod relative to the blocking feature.

Abstract: A drive unit for a medicament delivery device is presented having an elongated plunger rod extending in a longitudinal direction, a drive force element capable of applying a drive force on the elongated plunger rod, and an actuator operably connected to the elongated plunger rod for releasably holding the elongated plunger rod in an energized state when the drive force element is exerting a drive force on the elongated plunger rod. An activator is operably connected to the actuator for releasably holding the actuator in a holding position where the actuator is designed to be movable from the holding position in a direction generally transversal to the longitudinal direction upon a displacement of the activator for releasing the plunger rod.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end, operate the syringe to supply the dose of medicament, and retract the syringe with the needle after delivering the medicament. An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.

Abstract: A vial assembly includes a vial and a needle with at least one port. The vial includes a particulate material, a septum, a neck region including a first width, and a particulate region including a second width greater than the first width. The vial assembly is configured to move to a locked position. The needle may be configured to puncture the septum with the at least one port configured to be in the neck region when in the locked position. The at least one port may be configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of a vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second direction opposite the first direction.

Abstract: Provided is a fluid wicking tip. The fluid wicking tip includes a plurality of drip flanges arranged to wick fluid between narrow spaces defined between any two drip flanges. The narrow spaces are dimensioned to facilitate wicking by capillary action. Also provided is a syringe that includes the fluid wicking tip. Also provided is a spike tip including a series of tiered drip flanges for retaining fluid spilled from a bulk fluid container during a syringe filling operation.

Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Abstract: A safety member for use with an injection device is disclosed. The safety member includes a blocking ring extending into a housing of the injection device in blocking association with a latch member associated with a trigger mechanism of the injector, in which the blocking ring blocks movement of a portion of the trigger mechanism into a firing position. The safety member further includes a manipulable portion disposed outside the housing and configured for hand-manipulation by a user to remove the safety member from the housing to unblock the firing mechanism to enable firing of the injector.

Abstract: A pre-filled medical delivery assembly assembled and configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another.

Abstract: The present invention relates to an RDID tag enabled shield assembly that provides a sterile enclosure of a medicament delivery port of a medicament container. The container can be a needleless pre-filled syringe, a vial, a cartridge, or a collapsible bag or pouch. The RFID tag is fixedly attached to one or more components of the shield assembly through co-molding or another form of permanent or removable attachment. The present invention also relates to a method of tracking the life cycle of a medicament container or a medicament injection device where the RFID tag enabled shield assembly attached to the medicament container. Data is written to or read from the RFID tag during the entire life cycle of the medicament container or injection device, including assembly, packaging, storing, distribution and use.

Abstract: Various exemplary drug delivery devices with a spinning nozzle, drug products utilizing the same, and methods of using drug delivery devices with a spinning nozzle are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom includes a spinning nozzle configured to facilitate the drug's ejection into a patient's nose. The spinning nozzle is located between a drug holder containing the drug to be dispensed and an opening of the drug delivery device through which the drug exits the drug delivery device. The spinning nozzle is configured to spin during the drug's delivery as the drug travels from the drug holder and out of the drug delivery device. The spinning nozzle includes a plurality of perforations therein through which the drug as a liquid is configured to pass. The spinning of the spinning nozzle causes the drug to exit the drug delivery device as a fine mist.

Abstract: The invention relates to a method for determining compliance of a cavity in minimally invasive surgery and to devices for carrying out said method.

Abstract: The presently disclosed embodiments relate to insufflation and irrigation conduits for vessel harvesting systems and methods of their use. In particular, the present disclosure relates to a system having a combined cabling for providing gases, liquids, and/or electrical power to an attached medical device and method of use.

Abstract: There is provided a dose counter assembly for use with a medicament dispenser, the dose counter assembly comprising: a) a units dose display means comprising a first count indicia and one or more driver teeth; b) a tens dose display means comprising a second count indicia; and c) a driver, wherein the first count indicia and second count indicia align at a common viewing area to collectively display a count sequence.

Abstract: Various exemplary drug delivery devices with lock-out before drug delivery, drug products utilizing the same, and methods of using drug delivery devices with lock-out before drug delivery are provided. In general, a nasal drug delivery device is configured to dispense a drug therefrom into a nose and is configured to be releasably coupled to an accessory. The accessory is a separate, independent member from the drug delivery device such that in its decoupled state, the accessory is completely removed from the drug delivery device.

Abstract: A respiratory assistance component is disclosed that changes shape when an electrical charge is provided. The amount of electrical charge that is applied may be based on values, characteristics, or user controlled parameters of the respiratory assistance system. The component may be all or part of a patient interface, a tube, a flow generator, and/or a sleep mat.

Abstract: Techniques described herein can identify usage information for sensors. In one example, an anesthesia device can include a processor to obtain usage information from a first flow sensor coupled to the anesthesia device. The processor can also determine the usage information exceeds a predetermined limit and generate an alert indicating the first flow sensor is to be replaced.

Abstract: A therapeutic gas delivery system with at least one gas supply subsystem is disclosed. The at least one gas supply subsystem may include a gas source coupling configured to receive a therapeutic gas source and form a fluid flow connection with the therapeutic gas source, a therapeutic gas delivery system controller, and one or more display(s) configured to be in communication over a communication path with the therapeutic gas delivery system controller. The display may be configured to display a graphical, illustrative, or numerical indicator of one or more flow or system parameters.

Abstract: Systems and methods for lung-protective ventilation are disclosed. In examples, volume-targeted, pressure-controlled ventilation may deliver mandatory breaths to a patient without a rise time setting. Inputs into the ventilation may include a peak inspiratory flow value (Qpeak) and a target tidal volume (VT,set). Respiratory parameters of the patient may be determined based on test breaths. The inputs and the respiratory parameters may be used to calculate a target inspiratory pressure (Pi) and target rise time constant (?). Breaths may then be delivered based on the calculated target inspiratory pressure and target rise time constant. Mechanical power delivered to the patient may also be monitored as an additional measure for patient lung protection.

Abstract: According to an aspect, there is provided a cannula for use in high flow nasal therapy, comprising: a first tube for directing a first fluid from a nasal cavity of a subject to a location outside of the subject; a second tube for directing a second fluid from a supply of the second fluid to the nasal cavity of the subject; a flow sensor located within the first tube, the flow sensor configured to measure a flow rate of the first fluid moving through the first tube; and a humidity sensor located within the first tube, the humidity sensor configured to measure a humidity of the first fluid moving through the first tube; wherein the measured flow rate and the measured humidity are to be used by a processor to control a humidifier to adjust a humidity of the second fluid to be supplied to the subject.

Abstract: A laryngeal mask airway (LMA) intubation guide for use in an endotracheal intubation procedure and in ventilation of a subject, the LMA intubation guide including: an elongate body defining a passageway extending between a proximal opening and a distal opening, for receiving a blade portion of an intubation device; a laryngeal mask at the distal opening, for covering the larynx of the subject; and a ventilation airway extending at least partially along the body, including: a ventilation port at a proximal end of the ventilation airway for connection to a ventilator; and a ventilation aperture at a distal end of the ventilation airway for allowing fluid communication between the ventilation airway and the passageway proximate to the laryngeal mask, the LMA intubation guide being configured to allow intubation of the subject using an endotracheal tube through the passageway, while the subject is ventilated using the ventilation airway.

Abstract: Disclosed herein are embodiments describing nonrebreather facemasks for efficiently and comfortably delivering oxygen to patients. One embodiment describes a cup-shaped pliable facemask that is suited to cover and seal a patient's nose, mouth, and cheeks within the cup-shaped facemask. Certain other embodiments describe an inlet tube outwardly extending from the facemask at an angle in line with the pathway of a patient's nostrils to better provide oxygen directly into a patient's nose. Other embodiments envision varying facemask's stiffness for improved comfort and sealing against the patient's face. While other embodiments envision a reduction in dead space of a facemask when worn by a patient to improve oxygen efficiency used by the patient.

Abstract: A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.

Abstract: A vent adaptor for a for a respiratory pressure therapy (RPT) system, the vent adaptor comprising: a vent assembly comprising: a vent housing defining a central orifice for the flow of pressurized gas to pass through the vent assembly from the delivery conduit to the patient interface, the vent housing having an annular surface around the central orifice, and the annular surface having a plurality of holes to discharge pressurized gas to atmosphere; and a membrane positioned adjacent to the annular surface; a heat and moisture exchanger (HME); and a diffusing member.

Abstract: A method and system of responding to adverse environmental conditions local to a user of an oxygen concentrator is disclosed. Physiological data of the user is collected. Operational data of the oxygen concentrator is collected during operation of the oxygen concentrator. Environment data local to the oxygen concentrator is collected. Based on the collected environmental data, it is determined whether adverse environmental conditions exist local to the oxygen concentrator. The collected physiological, operational, and environmental data are analyzed to determine a responsive action to the determined adverse environmental conditions. The responsive action is communicated to the user.

Abstract: A system for treating and/or preventing a viral, bacterial and/or fungal infection in the oral cavity and/or along the respiratory tract, in particular the interior of the nose, throat, trachea and/or lungs, of a patient by reactive species generated by plasma as well as a plasma for such use is disclosed. The system comprises a plasma source generating reactive species in a gas, the plasma source being configured to be located outside a body of the patient, and a species directing member forming at least one duct for guiding at least a part of the reactive species generated by the plasma source into the oral cavity and/or the respiratory tract.

Abstract: Disclosed is a respirator which comprises an electronic control device and a pneumatic main line in which the following are connected pneumatically: a respiratory gas source, a valve, a mixing chamber, a gas-dosing unit, and a supply line. The gas-dosing unit is configured to convey external air and/or oxygen and/or anesthetic gas into the mixing chamber, the respiratory gas source is configured to deliver respiratory gas to the supply line, the mixing chamber is configured to make available respiratory gas, the supply line is configured to supply the patient with respiratory gas, and the valve is configured to at least temporarily reduce a stream of respiratory gas to a patient.

Abstract: A humidification tank and a ventilation treatment device are provided. The humidification tank includes a tank body having a cavity, a connector pipe inserted into the cavity, and at least two branch pipes communicated with an outlet end of the connector pipe. The branch pipes can provide airflow towards different directions so that gas reaches more positions in the cavity, the existence of a position to which the gas cannot be blown in the cavity is avoided, the occurrence of a dead zone of airflow is avoided. The fluidity of gas inside the cavity is improved, and a gas flowing path is lengthened, thus improving the humidifying effect of gas.

Abstract: A system for introducing vibrational waves into a body of a subject to treat sleep disorders is provided. The system includes a bed frame having a first vibration contact and a second vibration contact. The first vibration contact is in mechanical communication with a first location of the body of the subject, and the second vibration contact is in mechanical communication with a second location of the body of the subject. A first vibration source is connected to the first vibration contact and configured to cause a first vibration of the first vibration contact. A second vibration source is connected to the second vibration contact and configured to cause a second vibration of the second vibration contact. The location or orientation of the first vibration contact and the second vibration contact are configured such that the first vibration combines with the second vibration to generate a super-imposed vibration.

Abstract: A monitoring system for use with a human simulator for simulating interaction between a human baby and a bonded human and method of operating thereof are disclosed. The simulator comprises a housing having an outer layer configured to contact the baby, the housing having a surface contoured to simulate a torso of the bonded human; a respiration simulation system configured to simulate a respiration motion of the bonded human; and a heartbeat simulation system configured to simulate a heartbeat of the bonded human. The monitoring system comprises a smart device having a first communication interface; one or more sensors for detecting one or more biological parameters of the bonded human; at least one processor programmed with machine readable instructions to activate the sensor(s) and to transmit a signal corresponding to the detected biological parameters from the first communication interface to a second communication interface connected to the simulator.

Abstract: The disclosure includes a catheter system comprising an inner catheter and an outer catheter configured to at least partially receive the inner catheter. In some embodiments, the inner catheter comprises a proximal hub, a distal portion, and a pusher wire extending between the proximal hub and the distal portion. The distal portion of the inner catheter may comprise a hypotube. In some embodiments, the inner surface of the hypotube is coated with a lubricious coating.

Abstract: An endoluminal device comprises a tubular member and a reinforcement member that is separable from, or together with, a wall of the tubular member, and removable in-situ.

Abstract: A hemostasis valve hub for an introducer sheath includes a hub base, a hub cap configured for engagement with the hub base, the hub cap having a first wall with a first opening and a second opening extending through the first wall, a manifold positioned within the hub cap and adjacent the hub base, a primary seal positioned adjacent the first opening of the hub cap, a secondary seal positioned adjacent the second opening of the hub cap, and wherein the primary seal and the secondary seal are configured to provide a fluid seal between the first opening and the second opening, respectively, and the hub base.

Abstract: Devices for transferring fluid to or from a subject include an extension tube assembly with an axially extending inner tube configured to couple to an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen and an axially extending inner tube. The inner tube extending through the tubular cannula defines an exposed needle tip and is in fluid communication with the inner tube of the extension tube assembly. The needle tip extends out of a distal end of the tubular cannula a suitable distance.

Abstract: A system includes an expandable distal-end assembly, a proximal position sensor, a distal position sensor, and a processor. The expandable distal-end assembly is coupled to a distal end of a shaft for insertion into a cavity of an organ of a patient. The proximal and distal position sensors are located at a proximal end and a distal end of the distal-end assembly, respectively. The processor is configured to estimate a position and a longitudinal direction of the proximal sensor, and a position of the distal sensor, all in a coordinate system used by the processor. The processor is further configured to project the estimated position of the distal sensor on an axis defined by the estimated longitudinal direction, and calculate an elongation of the distal-end assembly by calculating a distance between the estimated position of the proximal sensor and the projected position of the distal sensor.

Abstract: A catheter adapter includes a body having a first end and a second end positioned opposite the first end, with the body including an inlet port positioned between the first end and the second end and defining a longitudinal axis extending between the first end and the second end of the body, a catheter configured to be inserted into a patient's vasculature, with the catheter positioned at the first end of the body, and a stabilizer including a first wing member and a second wing member, with a portion of the stabilizer extending beyond the inlet port of the body in a direction extending along the longitudinal axis from the first end of the body to the second end of the body.

Abstract: Some embodiments of a medical device anchor system include an anchor device that receives a catheter (or other medical instrument) and secures the catheter in place relative to a skin penetration point. In some embodiments, the anchor device can secure the catheter in an operative position relative to the skin penetration point without use of sutures or skin tapes.

Abstract: A medical system includes a catheter and a vision probe that can be removed from the catheter and replaced with a medical probe. The vision probe can thus be used to steer and pose the catheter, and then be removed and replaced with the medical probe when a medical task such as a lung biopsy is performed. A sensor system in the catheter at least partly measures a pose of the catheter, and control logic controls actuation of the catheter to maintain the desired working configuration when the medical probe is used. A small diameter catheter can thus provide vision and biopsy functionality.

Abstract: According to an aspect, an implantable device includes a pressurize fluid reservoir configured to hold fluid, an inflatable member; and an electronic pump assembly. The electronic pump assembly includes a pump, an active valve, a pressure sensor configured to monitor a pressure of the inflatable member, and a controller configured to cause the active valve to be in an open position during at least a portion of an inflation cycle to allow the fluid to be transferred from the pressurized fluid reservoir to the inflatable member. The controller is configured to transition the active valve to a closed position in response to the pressure of the inflatable member achieving a target pressure.

Abstract: The present disclosure provides with a device (100) for temporary residence at an ileocecal valve of a subject, the device carrying a load of an active pharmaceutical ingredient (API) and having an expanded configuration. When the device is positioned at the ileocecal valve and in the expanded configuration, the device is configured to be retained at the ileocecal valve of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. This enables dispensing locally therapeutic substances at an ileocecal valve (ICV) region of a human body.

Abstract: A wearable phallic lubrication delivery system providing a sheath or framing extending between a closed distal end and an open proximal end for slidably receiving a phallus. An arcuate, circumferential bladder depends from the open proximal end, proximate thereof. A conduit is fluidly coupled to the bladder and extends longitudinally, along the sheath or framing, from adjacent the open proximal end to adjacent the closed distal end. The conduit is connected to but exclusive the sheath or framing. An outlet is provided at the distal end of the conduit, adjacent the tip of the closed proximal end, so that compression of the bladder urges fluid therein through the conduit and out the outlet, thereby simulating ejaculation.

Abstract: A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

Abstract: The invention concerns a device for introducing microneedles into the skin of a subject; and a method for inserting microneedles into the skin of a subject comprising use of said device.

Abstract: A needle assembly for a liquid applicator comprises a housing, a needle bundle, and an elastic tubular member. The housing comprises a longitudinal channel having upper and lower open ends. The needle bundle is movably mounted in the channel and configured to be driven by a driving shaft to reciprocatively move between a retracted position and an extended position. The elastic tubular member comprises a first end attached to the housing and a second end attached the needle bundle to bias the needle bundle to move longitudinally towards the retracted position. The tubular member comprises a first portion and a second portion thinner than the first portion, which are separated by a boundary. The boundary extends helically between the first and second ends of the tubular member. The first portion may include one or more helical ridges.