Patents Issued in September 28, 2023
  • Publication number: 20230302158
    Abstract: Artificial expression constructs for modulating gene expression in striatal neurons are described. The artificial expression constructs can be used to express heterologous genes in striatal neurons including in striatal medium spiny neuron-pan, striatal medium spiny neuron-indirect pathway, striatal medium spiny neuron-direct pathway, striatal interneuron-cholinergic, and Drd3+ medium spiny neurons in olfactory tubercle. The artificial expression constructs can be used for many purposes, including to research and treat movement disorders such as Parkinson's disease and Huntington's disease.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • Publication number: 20230302159
    Abstract: Disclosed are compounds with the following structure (Formula (I)) where (Formula (II)) or (Formula (III)), X is an anion (e.g., a biologically suitable anion, such as, for example, chloride, iodide, and the like). Y is NH, NR10, or CR11R12. Z is a heteroatom (e.g., O, S, or Se). R and R1 are independently chosen from methyl, ethyl, propyl (e.g., n-propyl, isopropyl), butyl (e.g., n-butyl, isobutyl, tert-butyl), and the like, and combinations thereof. In various examples, R and R1 are not both oxygen atoms (such that an —NO2 is formed). R2 and R3 are independently chosen from methyl, ethyl, propyl (e.g., n-propyl, isopropyl), butyl (e.g., n-butyl, isobutyl, tert-butyl), and the like, and the like, and combinations thereof. R4, R5, R6, R7, R8, R9, R10, R11, and R12 are independently chosen from hydrogen, alkyl groups (e.g., methyl, ethyl, propyl (e.g., n-propyl, isopropyl), butyl (e.g., n-butyl, isobutyl, tert-butyl)), and the like, and combinations thereof.
    Type: Application
    Filed: August 16, 2021
    Publication date: September 28, 2023
    Inventors: Ching-Hsuan Tung, Brian D. Gray, Koon Yan Pak
  • Publication number: 20230302160
    Abstract: Disclosed are a tumor contrast compound, a preparation method therefor and an application thereof in tumor diagnostic imaging. A contrast agent of the present invention comprises the compound as represented by formula I in this text and anionic surfactant. Near-infrared real-time imaging having high contrast ratio and clear and distinguishable imaging results can be achieved by using the contrast agent of the present invention.
    Type: Application
    Filed: August 26, 2021
    Publication date: September 28, 2023
    Inventor: Weiwei Wang
  • Publication number: 20230302161
    Abstract: Provided is a method for preparing a carbon-13-containing graphene quantum dot available as an MRI contrast medium, a carbon-13-containing graphene quantum dot prepared by the method, and an MRI contrast medium comprising the carbon-13 graphene quantum dot.
    Type: Application
    Filed: August 25, 2021
    Publication date: September 28, 2023
    Applicants: BIOGRAPHENE INC., SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
    Inventors: Byung Hee HONG, Young Jin JUNG, Jong Bo PARK
  • Publication number: 20230302162
    Abstract: The present inventors have developed new radiolabeled Darapladib and analogs thereof which can be used for the specific detection of vulnerable atherosclerotic plaques by targeting lipoprotein-associated phospholipase A2 (Lp-PLA2) which is a biomarker of choice concerning inflammation and atherosclerosis progression. Thus, the present invention relates to radiolabeled Darapladib and analogs thereof and their use as imaging compounds.
    Type: Application
    Filed: December 5, 2022
    Publication date: September 28, 2023
    Inventors: Olivier MEILHAC, Emmanuelle JESTIN, Florian GUIBBAL, Sébastien BENARD
  • Publication number: 20230302163
    Abstract: The radiopharmaceutical 177Lu-PSMA I&T is provided, including in high purities with extended shelf life. Further provided are methods of synthesis of 177Lu-PSMA I&T and pharmaceutical compositions and methods of treatment that comprise 177Lu-PSMA I&T.
    Type: Application
    Filed: September 22, 2022
    Publication date: September 28, 2023
    Inventor: Joe McCann
  • Publication number: 20230302164
    Abstract: Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and/or detect cancers associated with increased PSMA expression, have the formula: and include complexes, anions or salts thereof. R1 includes a chelating moiety; a is 0 or 1; n is an integer from 12 to 21; and R2 includes a prostate specific membrane antigen (PSMA)-targeting moiety. Optionally, the chelating moiety is chelated to a metal atom, where the metal atom is a positron or single photon emitting metal isotope, or an alpha, beta, or Auger emitting metal isotope.
    Type: Application
    Filed: April 20, 2023
    Publication date: September 28, 2023
    Inventors: Reinier HERNANDEZ, Anatoly PINCHUK
  • Publication number: 20230302167
    Abstract: The invention provides compositions and methods for treating cancers and proliferative disorders, including solid tumor cancers and non-myeloid hematological malignancies, using radioconjugates targeting CD33, alone or in combination with one or more radioconjugates targeting other cancer-associated targets such as DR5, 5T4, HER2, HER3, and TROP2, antibody drug conjugates targeting these or other cancer-associated targets, therapeutic antibodies targeting these or other cancer-associated targets, chemotherapy agents and regimens, and immune checkpoint inhibitors.
    Type: Application
    Filed: August 8, 2022
    Publication date: September 28, 2023
    Inventors: Mary M. Chen, Avinash Desai, Dale L. Ludwig, Mark Berger, Sandesh Seth
  • Publication number: 20230302168
    Abstract: Methods for treating a proliferative disease or disorder by administering an antibody radio-conjugate alone or in combination with an immune checkpoint therapy such as an antibody against an immune checkpoint inhibitor, and/or a DNA damage response inhibitor. The proliferative disease or disorder may be a solid cancer, such as breast cancer, ovarian cancer, or prostate cancer.
    Type: Application
    Filed: June 23, 2021
    Publication date: September 28, 2023
    Inventors: Dale LUDWIG, Eileen GEOGHEGAN
  • Publication number: 20230302169
    Abstract: The invention provides a method for producing a solution containing 211At? (astatide ion) at a high radiochemical purity by using 211At obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived from 211At. The invention also provides a solution containing 211At? (astatide ion) at a radiochemical purity of not less than 30%.
    Type: Application
    Filed: May 15, 2023
    Publication date: September 28, 2023
    Applicant: OSAKA UNIVERSITY
    Inventors: Yoshifumi SHIRAKAMI, Tadashi WATABE, Kazuko KANEDA, Eku SHIMOSEGAWA, Atsushi SHINOHARA, Jun HATAZAWA
  • Publication number: 20230302170
    Abstract: The present invention relates to a system (1000) for cleaning and/or disinfecting a tool (600) for dental or surgical use, comprising a steam generator (100) and a compressed air source (200), the cleaning and/or disinfecting system (1000) further comprising a flow regulating device (400) designed to inject wet steam (1) and compressed air (2) into at least one channel of the tool (600) for dental or surgical use that is to be treated.
    Type: Application
    Filed: December 3, 2021
    Publication date: September 28, 2023
    Inventors: Davide SARCHI, Marco GALLINA, Edgar SCHÖNBÄCHLER
  • Publication number: 20230302171
    Abstract: An inactivation device inactivates microorganisms and/or viruses present in a space where a person is present by irradiating the space with ultraviolet light. The inactivation device includes a mobile body movable in the space, a drive section that drives the mobile body, an ultraviolet light irradiation unit provided with an ultraviolet light source emitting light including ultraviolet light having a wavelength that inactivates microorganisms and/or viruses, and a controller that controls the irradiation of the light from the ultraviolet light source. The ultraviolet light source is either an excimer lamp or an LED, and the ultraviolet light included in the light emitted from the ultraviolet light source includes ultraviolet light having a wavelength range from 200 nm to 240 nm. The ultraviolet light irradiation unit is fixed to the mobile body.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 28, 2023
    Applicant: Ushio Denki Kabushiki Kaisha
    Inventors: Hiroyuki Ohashi, Shinji Suzuki
  • Publication number: 20230302172
    Abstract: An inactivation device, in a space inside a mobility means that transports a person or an object, that inactivates microorganisms and/or viruses present in the space where a person is present by irradiating the space with ultraviolet light, the inactivation device includes: an ultraviolet light irradiation unit including an ultraviolet light source emitting light including ultraviolet light having a wavelength that inactivates microorganisms and/or viruses; and a controller that controls the irradiation of the light emitted from the ultraviolet light source. The ultraviolet light source is either an excimer lamp or an LED, and the ultraviolet light included in the light emitted from the ultraviolet light source includes ultraviolet light having a wavelength range from 200 nm to 240 nm. The ultraviolet light irradiation unit is fixed to the mobility means.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 28, 2023
    Applicant: Ushio Denki Kabushiki Kaisha
    Inventors: Hiroyuki Ohashi, Shinji Suzuki
  • Publication number: 20230302173
    Abstract: In order to solve the above problems, an object of the present invention is to provide an ultraviolet light irradiation system and an ultraviolet light irradiation method with a few transmission losses in an optical fiber. The ultraviolet light irradiation system 301 includes: a light source unit 11 for injecting transmission infrared light into an optical fiber 50, a wavelength conversion unit 12 for converting the transmission infrared light propagated through the optical fiber 50 into ultraviolet light, and an irradiation unit 13 for irradiating the ultraviolet light on a desired place. The light source unit 11 has a polarization scrambler 11b, and infrared light output from one infrared light source 11a is made to be transmission infrared light by the polarization scrambler 11b.
    Type: Application
    Filed: October 21, 2020
    Publication date: September 28, 2023
    Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATION
    Inventors: Tomohiro TANIGUCHI, Ayako IWAKI, Kazuhide NAKAJIMA, Nobutomo HANZAWA, Takashi MATSUI, Yuto SAGAE, Chisato FUKAI
  • Publication number: 20230302174
    Abstract: A handle comprises a grip and an ultraviolet radiation emitter operable to emit ultraviolet radiation to disinfect the grip. The grip has a body extending in a longitudinal direction between a proximal end surface located at a proximal end of the grip and a distal end surface located at an opposing distal end of the grip. The ultraviolet radiation emitter is located at the proximal end of the grip and configured to emit ultraviolet radiation. In some embodiments, the ultraviolet radiation emitter is configured to direct ultraviolet radiation from the proximal end and in directions oriented toward the body.
    Type: Application
    Filed: March 29, 2023
    Publication date: September 28, 2023
    Inventors: Fariborz TAGHIPOUR, Mahyar Mohaghegh MONTAZERI, Babak Adeli KOUDEHI, Majid KESHAVARZFATHY
  • Publication number: 20230302175
    Abstract: The invention relates to sterilisation systems suitable for clinical use, e.g. on the human body, medical apparatuses, or hospital bed spaces. In particular, the invention provides a sterilisation apparatus comprising: a sterilisation device having a hydroxyl radical generating region and an outlet for directing generated hydroxyl radicals out of the hydroxyl radical generating region towards a region to be sterilised; and a steam supply connected to deliver dry steam to the sterilisation device, wherein the sterilisation device is configured to generate a high impedance at the hydroxyl radical generating region when dry steam, radiofrequency (RF) and/or microwave frequency electromagnetic (EM) energy, and gas are delivered to the hydroxyl generating region, thereby to create a plasma of the gas which forms an ionisation discharge for generating hydroxyl radicals from the dry steam for delivery out of the hydroxyl generating region.
    Type: Application
    Filed: July 15, 2021
    Publication date: September 28, 2023
    Inventors: Christopher Paul HANCOCK, Jolyon DE FOSSARD, Steven MORRIS
  • Publication number: 20230302176
    Abstract: Disclosed is a process for treating at least one hollow body made of thermoplastic material, such as a preform or a cap, the treatment process successively including at least the following steps: a first step, consisting in treating at least the inside of the hollow body using hydrogen peroxide; a second step, consisting in heating the hollow body; a third step, consisting in treating the hollow body with plasma in order to reduce the concentration of hydrogen peroxide residues. Also disclosed is a plant for manufacturing containers in which the process is carried out in particular by way of a unit for the plasma treatment of the preforms.
    Type: Application
    Filed: June 2, 2023
    Publication date: September 28, 2023
    Inventor: Véronique BERNARD
  • Publication number: 20230302177
    Abstract: A medical end-site disinfecting device including an interface device and a volume of liquid disinfectant. The interface device is configured to interface with a medical end-site, and includes at least one of a housing, an element, and a core. At least one component of the interface device defines at least one capillary channel. The volume of liquid disinfectant is retained along the capillary channel. The capillary channel is configured to generate a capillary effect to transport the liquid disinfectant along the interface device. In some embodiments, the capillary channel is configured to retain at least a portion of the volume of liquid disinfectant along a length of the capillary channel, for example to apply the retained volume of the liquid disinfectant device onto the medical end-site during use.
    Type: Application
    Filed: August 17, 2022
    Publication date: September 28, 2023
    Applicant: 1WorldVista Medical, Inc.
    Inventor: Michael J. Ferlic
  • Publication number: 20230302178
    Abstract: A method of removing pathogens from a surface is described. In particular, a method including providing a wipe including guanidinyl-containing polymer coating, providing a liquid disinfectant having an associated disinfection time t for at least one pathogen is described. The method may help provide safe levels of disinfection even with a significant associated error in dwell time.
    Type: Application
    Filed: August 26, 2021
    Publication date: September 28, 2023
    Inventors: Andrew W. Vail, Robert A. Schmitz
  • Publication number: 20230302179
    Abstract: The present disclosure relates to sterilization monitoring devices, as well as and methods and kits for evaluating sterilization processes using sterilization monitoring devices.
    Type: Application
    Filed: August 10, 2021
    Publication date: September 28, 2023
    Inventors: Joshua D. ERICKSON, Giuseppe M. BOMMARITO, Ryan T. WOLDT, Timothy J. NIES, Jeffrey M. FLYNN
  • Publication number: 20230302180
    Abstract: A sensor component is sterilised for use in a system for measuring the concentration of one or more analytes in fluid in a fluid line. The sensor component comprises one or more sensing elements having an optical property that varies with the concentration of the one or more analytes in the fluid, and is configured to engage with the fluid line such that the sensing elements are exposed to the fluid. The method comprises introducing a gaseous sterilising agent into a sealed cavity via one or more ports providing fluid connection to the cavity, wherein the one or more sensing elements are exposed to the cavity, replacing the gaseous sterilising agent with a sterile liquid via the ports, and sealing the ports. Also disclosed is a sensor component with a configuration facilitating the application of the method.
    Type: Application
    Filed: January 25, 2022
    Publication date: September 28, 2023
    Applicant: SciLogica Corp.
    Inventors: Barry Colin CRANE, Janet Lesley WALTERS, Nicholas Paul BARWELL, Praveen SAGAR, Alasdair Allan MACKENZIE
  • Publication number: 20230302181
    Abstract: The invention relates to a fully automated sanitizing system (1) for shopping trolleys and the like. It provides an automated sanitization and disinfection process, divided into four phases, which guarantees the user to pick up the perfectly sanitized trolley without contact with third parties and steps for other hands, ready for its first use. The system (1) in question consists of an automated island to be placed in the parking area of supermarket or shopping center and consists of two adjacent units, one of which is intended for the storage of used trolleys where subsequently will carry out the sanitization cycle, the other destined to shelter and store the trolleys already sanitized and ready for collection in several rows. The sampling area has been designed in compliance with the anti distances aggregation. The use of this system (1) guarantees the almost total elimination of viral and bacterial loads on the trolleys.
    Type: Application
    Filed: August 9, 2021
    Publication date: September 28, 2023
    Inventors: Franco PONTONE, Michele PONTONE
  • Publication number: 20230302182
    Abstract: A system for disinfecting surfaces in a space, such as a vehicle or a building. The system may include a disinfecting module having a UVC light source and/or an ambient heat source for disinfecting the space. In some embodiments, an occupancy sensor is incorporated within the module. In some embodiments, control of the system in incorporated into the functionality of a ride-share application to facilitate disinfection of the vehicle between occupant rides.
    Type: Application
    Filed: August 9, 2021
    Publication date: September 28, 2023
    Inventors: Sung-Uk KIM, Carter Scott CANNON
  • Publication number: 20230302183
    Abstract: A low profile disinfection and delivery system that utilizes a channel lighting system with a parabolic multifunctional anisotropic reflector for effectively distributing the power of UV LEDs. The channel lighting system delivers specific energy patterns to the target surface. The channel lighting system can be provided as a more integrated UV delivery system. The homogenous delivery and distribution of patterned energy enables better use and efficiency of the available UV LED power.
    Type: Application
    Filed: January 31, 2023
    Publication date: September 28, 2023
    Inventors: Michael Halloran, Ryan D. Schamper, Colin J. Moore, David W. Baarman, David Alan Jerovsek
  • Publication number: 20230302184
    Abstract: A safe disposal machine for peritoneal dialysis liquid waste comprises a box main body, with ultraviolet lamps for box internal disinfection provided at the top of the box's interior, a weighing device for peritoneal dialysis liquid waste weighing provided at the top of a filter plate, a placing and cutting device for drainage bag cutting provided at the top of the weighing device, and a flushing and disinfection device for drainage bag disinfection provided in the box. The invention can weigh the drainage bag, facilitating the recording of the peritoneal dialysis ultrafiltration volume for patients; the placing and cutting device can take down the weighed drainage bag, and simultaneously cut the drainage bag into a cross shape to pull outwards; the drainage bag capable of inner-side turning over can facilitate the complete washing through flushing and disinfection device, to avoid the residual liquid waste endangering others and the environment.
    Type: Application
    Filed: March 20, 2023
    Publication date: September 28, 2023
    Inventors: Lingcang Xu, Haixue Lin, Fangfang Zhou, Qun Luo, Beixia Zhu, Congping Xue, Meng Li, Zhiwei Dai, Qilin Sheng
  • Publication number: 20230302185
    Abstract: An apparatus for processing an artificial tooth with a disinfection and sterilization function includes: a work bed unit in which a tooth mother material selected from a titanium material or a zirconia material is installed and fixed, and in which a wet-type die that processes a titanium material and a dry-type die that processes a zirconia material are separately disposed; a processing tool unit that has a driving spindle to which a processing tool is coupled at an end thereof and that processes the tooth mother material while moving close to or away from the tooth mother material; and a disinfection/sterilization module that is coupled in a detachable type in the work bed unit and can simultaneously reduce powder and perform disinfection
    Type: Application
    Filed: November 24, 2022
    Publication date: September 28, 2023
    Applicant: ZEUS TECH CO., LTD.
    Inventor: Hong Youn KIM
  • Publication number: 20230302186
    Abstract: A virus removal device providing a high virus removal probability, a small pressure loss of a flowing gas, and miniaturization with respect to an amount of air to be treated, by adopting a wet mechanism for removing a virus from a gas, the virus removal device includes a cylindrical treatment room to introduce a gas and remove a virus, a catcher formed of a rotary brush, installed in the treatment room and configured to collect the virus contained in the gas, a liquid spraying mechanism in the treatment room, a rotary driving mechanism to rotate the catcher, a gas introducing portion to introduce the gas to the treatment room, a gas discharging portion to discharge the gas from which the virus has been removed from the treatment room, and a liquid discharging portion to discharge a liquid containing the virus that has been removed from the gas.
    Type: Application
    Filed: October 11, 2021
    Publication date: September 28, 2023
    Inventor: Toshio AWAJI
  • Publication number: 20230302187
    Abstract: An ultraviolet (UV) disinfection device comprises a housing shaped to define a chamber. The chamber comprises an inlet, an outlet, and one or more dividers arranged to define one or more flow paths between the inlet and the outlet. The dividers are preferably made of a UV transparent material. A UV radiation emitter is provided inside the chamber of the UV disinfection device to deliver UV radiation to air flowing through the chamber.
    Type: Application
    Filed: August 26, 2021
    Publication date: September 28, 2023
    Inventor: Stuart Victor SQUIRES
  • Publication number: 20230302188
    Abstract: A universal expandable system for purification and disinfection of air and methods of its use, and in particular to a system and apparatus that eliminates harmful airborne particles and microorganisms from ambient air as it passes through the system, so as to prevent the organisms and particles from entering the body of an individual user of the system. An air purification and disinfection device that is a major component of the system includes a housing having at least one disinfection chamber. Each disinfection chamber has a UV light source and a helical air flow diverter. Air purified and disinfected as it is passed through the device before the air flow is delivered to the user(s) of the device.
    Type: Application
    Filed: June 2, 2023
    Publication date: September 28, 2023
    Inventor: Madhavan Pisharodi
  • Publication number: 20230302189
    Abstract: A composite material is formed by combining an expandable polymer having a charge with another polymer having an opposite charge to produce.
    Type: Application
    Filed: February 15, 2023
    Publication date: September 28, 2023
    Applicant: The Penn State Research Foundation
    Inventors: Jeffrey M. Catchmark, Yuzhi Deng
  • Publication number: 20230302190
    Abstract: A two-dimensional material for the medical wound area treatment is disclosed. A non-woven fabric consists of resorbable polymer filaments and collagen particles which have a particle size I >80 ?m and are disposed on and/or in the non-woven fabric.
    Type: Application
    Filed: June 1, 2023
    Publication date: September 28, 2023
    Applicant: PolyMedics Innovations GmbH
    Inventors: Heinrich Planck, Erhard Mueller, Svenja Reimer, Christian Planck
  • Publication number: 20230302191
    Abstract: In one aspect, a composition for sustained release of oxygen to a tissue is disclosed that includes at least one core-shell oxygen release microsphere (ORM), wherein the core includes a water-soluble polymer-reactive oxygen species (ROS) complex and the shell includes a biodegradable polymer conjugated to a ROS-scavenging enzyme. In some aspects, the reactive oxygen species includes hydrogen peroxide (H2O2), the ROS-scavenging enzyme includes catalase, the water-soluble polymer includes polyvinylpyrrolidone (PVP), and the biodegradable polymer includes poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-co-acrylate-oligolactide-co-Nacryloxysuccinimide)[poly(NIPAAm-co-HEMA-co-AOLA-co-NAS)].
    Type: Application
    Filed: January 31, 2023
    Publication date: September 28, 2023
    Applicant: Washington University
    Inventors: Hong Niu, Ya Guan, Jianjun Guan
  • Publication number: 20230302192
    Abstract: In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site, In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.
    Type: Application
    Filed: June 1, 2023
    Publication date: September 28, 2023
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Gerald FREDRICKSON, Amanda L. SMITH, Andrew PIC, Sophia GERVASIO, Lauren LYDECKER
  • Publication number: 20230302193
    Abstract: A plaster preparation includes (a) at least one resorbable polymer made of at least three monomer units, in particular a terpolymer, having monomers selected from the group consisting of trimethylene carbonate, glycolide, lactide (in particular DL-lactide), p-dioxanone, ?-caprolactone and/or butyrolactone; (b) at least one readily vaporizable organic solvent; and (c) at least one propellant. The plaster preparation additionally relates to a polymer film, to a spray plaster spray device, to a method for producing polymer fiber nonwoven materials, to a polymer fiber nonwoven material, and to uses of the plaster preparation.
    Type: Application
    Filed: June 1, 2023
    Publication date: September 28, 2023
    Applicant: PolyMedics Innovations GmbH
    Inventors: Heinrich Planck, Erhard Mueller, Svenja Reimer, Christian Planck, Lisa Lang
  • Publication number: 20230302194
    Abstract: The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.
    Type: Application
    Filed: March 23, 2023
    Publication date: September 28, 2023
    Inventors: Martin Franke Tooren, Dirk Erik Muller, Konstantin Igorovitch Denisov
  • Publication number: 20230302195
    Abstract: An injectable medical composition includes an acrylate and a solvent. The composition has a first viscosity at temperatures below body temperature and a second viscosity at body temperature. The first viscosity is lower than the second viscosity.
    Type: Application
    Filed: May 5, 2023
    Publication date: September 28, 2023
    Applicant: QMARK MEDICAL INC.
    Inventors: Patrick H. RUANE, Sameer SHARMA
  • Publication number: 20230302196
    Abstract: Nanofiber structures are provided as well as methods of use thereof and methods of making.
    Type: Application
    Filed: July 20, 2021
    Publication date: September 28, 2023
    Inventors: Jingwei XIE, Shixuan CHEN
  • Publication number: 20230302197
    Abstract: The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition including hydroxypropyl methylcellulose and a preparation method therefor. Moreover, the present disclosure relates to a bone graft composition that has an optimal composition ratio at which the dissolution rate of hydroxypropyl methylcellulose is excellent. In addition, the present disclosure relates to a bone graft composition containing hydroxypropyl methylcellulose in an amount that provides shape retainability, and a preparation method therefor. More specifically, the present disclosure relates to a bone graft composition containing hydroxypropyl methylcellulose in an amount that provides an optimum osmotic pressure and shape retainability, and a preparation method therefor.
    Type: Application
    Filed: February 16, 2023
    Publication date: September 28, 2023
    Applicant: MedPark Co.,Ltd
    Inventor: JungBok Park
  • Publication number: 20230302198
    Abstract: The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and on-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes.
    Type: Application
    Filed: May 3, 2023
    Publication date: September 28, 2023
    Inventor: Ryanne Early
  • Publication number: 20230302199
    Abstract: In accordance with the method of the present invention, 3D tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to mimic the natural tissue environment, thereby effectively guiding tissue regeneration. The method involves incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers to prepare tissue-derived scaffolds in the aforementioned formats. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 28, 2023
    Applicant: The Trustees of The Stevens Institute of Technology
    Inventors: Hongjun Wang, Meng Xu, Deep Parikh, Jin Zou, Weiwei Wang
  • Publication number: 20230302200
    Abstract: Autologous prevascularized breast tissue constructs created via 3D printing and methods for 3D printing autologous prevascularized breast tissue constructs. The method comprises steps of: (i) providing a triculture consisting of adipose mesenchymal stem cells, fibroblasts, and endothelial progenitor cells, (ii) mixing the triculture cells with a bioink composed of biopolymers, (iii) printing three-dimensional structures of the breast tissue construct using the triculture-added bioink from step (ii), where the cells of the triculture are pretreated with growth media before printing so that the endothelial progenitor cells differentiate into endothelial cells and the adipose mesenchymal stem cells differentiate into adipocytes. After 3D printing, the development of vascular-like structures is induced.
    Type: Application
    Filed: August 10, 2021
    Publication date: September 28, 2023
    Inventors: Martin Heller, Walburgis Brenner
  • Publication number: 20230302202
    Abstract: Embodiments of the present disclosure pertain to bioink compositions that are operational to form an artificial tissue. The bioink may include materials that are completely or primarily derived from humans, such as human tissues. Additional embodiments of the present disclosure pertain to artificial tissues that include a plurality of cells and a bioink of the present disclosure, where the bioink is embedded with the cells, and the artificial tissue is in the form of a three-dimensional structure. Further embodiments of the present disclosure pertain to methods of making the artificial tissues of the present disclosure by applying a plurality of cells and a bioink onto a surface.
    Type: Application
    Filed: March 24, 2023
    Publication date: September 28, 2023
    Applicant: Texas Tech University System
    Inventors: Sanjay K. Srivastava, Shreyas Gaikwad
  • Publication number: 20230302203
    Abstract: An implant capable of maintaining, even when being implanted in a body for a long period of time, desirable mechanical properties, non-bioabsorbable properties, and/or biocompatibility is provided. The implant contains a nanocomposite hydrogel obtained through formation of an organic-inorganic network structure in which an amide group-containing polymer compound and an inorganic clay nano-sheet are linked.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 28, 2023
    Inventors: Samuel JK ABRAHAM, Kazutoshi HARAGUCHI
  • Publication number: 20230302204
    Abstract: An object of this invention is to simultaneously achieve, in long-term transplantation of a macroencapsulation immunoisolation device using a porous membrane or the like, improvement in the diffusion efficiency of physiologically active substances released from a material to be transplanted, improvement in the diffusion efficiency of nutrients to cells and the like, which are the material to be transplanted, and uniform and efficient dispersion and fixation of cells and the like encapsulated as the material to be transplanted in the macroencapsulation immunoisolation device, while maintaining an immunoisolation effect. The present invention provides a hydrogel for embedding a material to be transplanted, comprising a polymer crosslinked by visible light, and water.
    Type: Application
    Filed: October 28, 2021
    Publication date: September 28, 2023
    Applicant: KURARAY CO., LTD.
    Inventors: Goro KOBAYASHI, Masako KAWAGOE, Akio FUJITA, Satoru AYANO
  • Publication number: 20230302205
    Abstract: Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.
    Type: Application
    Filed: May 26, 2023
    Publication date: September 28, 2023
    Inventors: Benjamin J. WILEY, Huayu TONG, Jiacheng ZHAO
  • Publication number: 20230302206
    Abstract: Identification systems, including anti-counterfeit and anti-reuse identification systems for automated peritoneal dialysis (APD) systems, and associated systems, devices, and methods are disclosed herein. In one embodiment, an APD system includes an identification system having at least one identification sensor configured to read device identifiers associated with disposable components of the APD system. The disposable components can include cassettes or source bags containing dialysate solution. In some embodiments, the identification system can (a) compare a device identifier of a disposable component to a whitelist of valid device identifiers, (b) determine whether the device identifier is valid, unused, and/or non-expired, and/or (c) based on the determination, determine whether to use the disposable component to execute an exchange treatment.
    Type: Application
    Filed: August 18, 2021
    Publication date: September 28, 2023
    Inventors: Farrukh Usman, Faisal Bashir, Abdul Qadeer, Salar Toor
  • Publication number: 20230302207
    Abstract: A medical fluid system includes a medical fluid pump configured to pump a medical fluid; electronics associated with the medical fluid pump or with other components of the medical fluid system; a thermoelectric heater positioned and arranged to heat medical fluid pumped by the medical fluid pump, the thermoelectric heater including a heated side and a cooled side; a heat exchanger through which medical fluid pumped by the medical fluid pump is heated, the heat exchanger positioned and arranged so as to be in thermal communication with the heated side of the thermoelectric heater; and a mounting plate, the electronics supported by the mounting plate, the mounting plate positioned and arranged so as to be in thermal communication with the cooled side of the thermoelectric heater.
    Type: Application
    Filed: March 23, 2023
    Publication date: September 28, 2023
    Inventors: Michael Pettersson, Jimmie Marcus Axel Hansson, Oskar Erik Frode Styrbjörn Fällman
  • Publication number: 20230302208
    Abstract: The invention relates to a dialysis treatment unit in which the connecting line to the central concentrate supply is also rinsed in the rinsing or cleaning process in order to prevent deposits therein.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 28, 2023
    Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Pia DANIEL, Stephan GOESSMANN, Klaus KARL, Georg VERCH
  • Publication number: 20230302209
    Abstract: A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.
    Type: Application
    Filed: April 17, 2023
    Publication date: September 28, 2023
    Applicant: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, James M. Brugger
  • Publication number: 20230302210
    Abstract: A peritoneal dialysis system includes a cycler having one or more air pump; a slotted housing including a plurality of slots each having a first side and a second side, wherein each respective slot of the plurality of slots includes a first expandable bladder fixed to the first side, and wherein each respective slot of the plurality of slots is configured to receive a fluid supply bag between the first expandable bladder and the second side, and a heater housing sized to hold a second expandable bladder, and wherein the heater housing is configured to receive a fluid heater bag adjacent to the second expandable bladder, wherein the one or more air pump is in fluid communication with the respective first expandable bladders and the second expandable bladder; and a disposable set operable with the cycler.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Inventor: Narendar VENKATACHALAPATHY