Patents Issued in September 28, 2023
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Publication number: 20230302262Abstract: Systems and methods for delivery of therapeutic materials for the treatment of cancer are disclosed. Some systems include a plurality of expandable occlusion members that can form seals with the inner walls of various vessels thereby isolating a section or region of the associated vessels. In some variations, the system may include one or more catheters that are in fluid communication and can transfer fluid around the isolated sections or region.Type: ApplicationFiled: March 15, 2023Publication date: September 28, 2023Inventors: Ramtin AGAH, Joseph F. PARASCHAC
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Publication number: 20230302263Abstract: A medical device assembly including a catheter having a proximal end, a distal end, and a lumen therethrough. A medical device is disposed about a distal portion of the catheter. A removable loading tool and protector is disposed about the catheter and the medical device, and includes a body having a generally tubular configuration and having a proximal end, a distal end, an intermediate region disposed between the proximal end and the distal end, and a lumen disposed therethrough; and a proximal region having a length and extending from the proximal end of the body, the proximal region having at least one slit positioned adjacent to the proximal end of the body. The proximal region has a first inner diameter and the intermediate region has a second inner diameter, the first inner diameter of the proximal region being greater than the second inner diameter of the intermediate region.Type: ApplicationFiled: January 26, 2023Publication date: September 28, 2023Applicant: Cook Medical Technologies LLCInventors: John Savage, Thomas Mindel, Michael Sayers, Joe Dervan, James Butler, Eugene Folan, Alec Cerchiari, Aaron Reid
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Publication number: 20230302264Abstract: A swallowable drug delivery device includes a capsule and a tissue attachment member. The capsule may contain a drug and may be sized to pass through at least a portion of the gastrointestinal tract of a patient. The tissue attachment member may be coupled to the capsule. In an initial state, the tissue attachment member may allow the capsule to pass through the at least a portion of the gastrointestinal tract of the patient. In an activated state, the tissue attachment member is configured to at least selectively attach the capsule to a wall of the gastrointestinal tract of the patient. The tissue attachment member may be configured to change from the initial state to the activated state in response to an in vivo condition associated with a predetermined location in the gastrointestinal tract of the patient.Type: ApplicationFiled: September 2, 2021Publication date: September 28, 2023Inventors: Mehran Mojarrad, Scott R. Gibson, Scott Castanon, Robert Eisele, Dylann Ceriani
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Publication number: 20230302265Abstract: This application relates to a microneedle patch and a method of manufacturing the microneedle patch. In one aspect, the microneedle patch includes a base, and a microneedle. The microneedle may contains an effective material, and protrude from a surface of the base. The microneedle may also include a plurality of layers. A concentration of the effective material may vary along a longitudinal direction of the microneedle.Type: ApplicationFiled: October 8, 2021Publication date: September 28, 2023Inventors: Jae Joon LEE, Yi Seul JEON
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Publication number: 20230302266Abstract: The present disclosure relates to a microneedle comprising a microfiber network structure, and more specifically, relates to a microneedle which comprises an insoluble microfiber network structure comprised in a substrate portion of a dissolving microneedle, so that it can deliver a large amount of an aqueous solution of drugs to skin through a hole for drug injection on the back side of a patch without including drugs in the microneedle, also regardless of drug types.Type: ApplicationFiled: June 18, 2021Publication date: September 28, 2023Applicant: LG HOUSEHOLD & HEALTH CARE LTD.Inventors: Ji-Eun SONG, Seung-Hyun JUN
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Publication number: 20230302267Abstract: The disclosure relates to a subcutaneously implanted port device for establishing access to the vascular system of a patient requiring multiple blood treatments over an extended period of time. The systems, devices and methods disclosed herein may reduce miscannulation, promote intra-session hemostasis, and decrease the incidence of bacteremia and sepsis among other improvements and advantages. The devices include a port with a tapered seat for receiving an access tube, the first tapered seat having a proximal portion, a distal portion, and a conical section extending between the proximal portion and the distal portion; and an interface surface configured to engage a blood vessel or a vascular access catheter. The proximal portion of the tapered seat is configured to receive the access tube therethrough, and the tapered seat creates a mismatch fit with a diameter of the access tube when in use for an increase in flow during treatment.Type: ApplicationFiled: May 16, 2023Publication date: September 28, 2023Applicant: Proviflo, LLCInventor: Charles David Finch, JR.
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Publication number: 20230302268Abstract: Some embodiments relate to a luer connector comprising a housing having a hollow bore therethrough, a first end, and a second end, a male luer tip supported by the housing configured to rotate with respect to the housing, the luer tip having a first open end and a passageway through the luer tip in fluid communication with the first open end, and a substantially rigid internal member extending into the passageway of the luer tip toward the first open end of the luer tip. In some embodiments, at least one of the luer tip and the internal member can be axially moveable between a first closed position and a second open position relative to the other of the luer tip and the internal member. Further, the luer tip and the internal member can cooperate such that rotation of the luer tip in a first direction relative to the housing increases an axial displacement between the first open end of the luer tip and an end portion of the internal member.Type: ApplicationFiled: October 10, 2022Publication date: September 28, 2023Inventors: Thomas F. Fangrow, Bruce Hubrecht, Harold Anderson, Christopher Lopez
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Publication number: 20230302269Abstract: Systems, methods, and apparatuses for irrigating a tissue site are described. The system can include a tissue interface and a sealing member configured to be placed over the tissue site to form a sealed space, and a negative-pressure source fluidly coupled to the sealed space. The system includes an irrigation valve having a housing, a piston disposed in the housing, a fluid inlet to fluidly couple a fluid inlet chamber to a fluid source, and a fluid outlet to fluidly couple a fluid outlet chamber to the sealed space. A piston passage extends through the piston and fluidly couples the fluid inlet chamber and the fluid outlet chamber, and a biasing member is coupled to the piston to bias the irrigation valve to a closed position. The negative-pressure source is configured to move the piston between the closed position and an open position to draw fluid to the sealed space.Type: ApplicationFiled: May 18, 2023Publication date: September 28, 2023Applicant: KCI Licensing, Inc.Inventors: Timothy Mark ROBINSON, Christopher Brian LOCKE, James A. LUCKEMEYER
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Publication number: 20230302270Abstract: A minimally invasive VAD installation system includes a curved hook having another hook at its distal end. The installation system also has a valve insertion tool having a gimbaled set of clamp jaws configured for releasably holding the inflow tube of a VAD pump. The installation system further has a pushing tool having a distal opening configured to pass over a tube.Type: ApplicationFiled: March 24, 2023Publication date: September 28, 2023Inventor: Jude S. Sauer
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Publication number: 20230302271Abstract: An intravascular blood pump having a drive section (11), a catheter (14) fastened to the drive section proximally and a pump section (12) fastened to the drive section distally possesses an electric motor (21) whose motor shaft (25) is mounted in the drive section (11) with two radial sliding bearings (27, 31) and an axial sliding bearing (40). During operation, purge fluid is conveyed through the bearing gap of the axial sliding bearing (40) and farther through the radial sliding bearing (31) at the distal end of the drive section (11). The purge fluid is highly viscous, for example 20% glucose solution.Type: ApplicationFiled: March 29, 2023Publication date: September 28, 2023Applicant: Abiomed Europe GmbHInventors: Gerd Bruno Spanier, Frank Kirchhoff, Thorsten Siess, Dirk Michels
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Publication number: 20230302272Abstract: A circulatory assist apparatus comprises an inflatable pumping balloon having a proximal end joined to an elongated balloon catheter, the catheter having a distal end joined to the pumping balloon and a proximal end, separated from the distal end by a length sufficient to extend from within the circulatory lumen to the outside of a patient's body, for receiving positive and negative pressure pulses from a pump to inflate and deflate the pumping balloon; a proximal expandable frame comprising a distal portion of an elongated shaft surrounding the catheter; and a distal expandable frame. The distal end of the elongated shaft is abuttable against a stopping element surrounding the catheter as the shaft is advanced towards the inflatable pumping balloon, or is joined to the catheter in which case the proximal expandable frame is heat set to deploy spontaneously to a predetermined diameter upon release of the elongated shaft.Type: ApplicationFiled: March 13, 2023Publication date: September 28, 2023Inventor: Constantinos Anagnostopoulos
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Publication number: 20230302273Abstract: An arrhythmia treatment device, the device may comprise: a first electrode configured to output a stimulus corresponding to input treatment conditions to electrically stimulate nerves of a user on the basis of the input treatment conditions; a second electrode configured to measure biosignals of the user for a predetermined time interval after the first electrode outputs the stimulus; and a controller configured to check an arrhythmia treatment result of the user on the basis of the biosignals measured for the predetermined time interval, and to control output of the first electrode based on the checked arrhythmia treatment result.Type: ApplicationFiled: May 30, 2023Publication date: September 28, 2023Inventors: Yunseo KU, Hee Chan KIM, Seil OH, Jang Jay SOHN
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Publication number: 20230302274Abstract: Systems and methods are provided for extracting an implanted lead from a patient's body. The system may include a dilator and a trephine for extracting the electrode lead. A sheath may be included that is advanced over the proximal end of an electrode lead until the distal end of the sheath abuts a collar of the electrode lead coupled to proximal fixation elements. The dilator may be rotatably and axially advanced over the sheath until the distal end of the dilator collapses the proximal fixation elements within a lumen of the dilator. The trephine may then be rotatably and axially advanced over the dilator such that a cutting edge of the trephine cuts tissue surrounding distal fixation elements of the electrode lead to thereby dislodge the electrode lead.Type: ApplicationFiled: March 18, 2023Publication date: September 28, 2023Applicant: Mainstay Medical LimitedInventors: Michael DAHL, Jason SKUBITZ
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Publication number: 20230302275Abstract: Presented herein is an electroporation shield configured to be removably coupled to an implantable stimulating assembly that includes one or more stimulation electrodes. The electroporation shield is coupled to stimulating assembly such that the electroporation shield electrically insulates the one or more of the stimulation electrodes from an electroporation electrical field generated by one or more electroporation electrodes coupled to the electroporation shield. The electroporation shield may be coupled to the stimulating assembly in a manner that facilitates removal of the electroporation shield and the one or more electroporation electrodes. After electroporation, without having to remove or reinsert the stimulating assembly, thereby exposing the one or more stimulation electrodes to the cells of the recipient for subsequent delivery of stimulation.Type: ApplicationFiled: August 18, 2021Publication date: September 28, 2023Inventor: Paul Michael CARTER
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Publication number: 20230302276Abstract: A medical system for obstructive sleep apnea (OSA) treatment includes therapy delivery circuitry configured to output one or more electrical stimulation signals to a tongue of a patient; sensing circuitry configured to sense one or more compound muscle action potential (CMAP) signals, wherein the one or more CMAP signals are generated in response to the delivery of the one or more electrical stimulation signals; and processing circuitry configured to: cause the therapy delivery circuitry to output the one or more electrical stimulation signals to the tongue; receive information indicative of the one or more CMAP signals from the sensing circuitry; determine, based on the one or more CMAP signals, one or more therapeutic stimulation parameters for the OSA treatment; and cause the therapy delivery circuitry to deliver therapeutic electrical stimulation signals according to at least the determined one or more therapeutic stimulation parameters.Type: ApplicationFiled: March 25, 2022Publication date: September 28, 2023Inventors: Leonid M. Litvak, Avram Scheiner, Kristin N. Hageman, Kanthaiah Koka, James Britton Hissong, Erik J. Peterson, David J. Miller, Robert T. Sandgren, Adam J. Rivard, Sean P. Skubitz, Thomas I. Miller
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Publication number: 20230302277Abstract: Method and system for facilitating healing or inhibiting development of a pulmonary and thrombosis ailment, such as a pulmonary lesion, a mediastinum condition of any etiology and pathogenesis, a pulmonary embolism, and a thrombotic or throm-boembolic condition. An ultrasound apparatus transmits ultrasound waves to a treatment region directed to a lung or thrombosis area od a patient, and an electrical stimulation apparatus applies electrical stimulation to the treatment region simultaneously with the ultra-sound waves transmission. Laser energy may further be applied to the treatment region. A medicant, such as systemic or transdermal thrombolytics, may also be applied. The transmitted ultrasound may be at 0.5-3 MHz frequency and at 0.5-2 W/cm2 intensity. The electrical stimulation may include electrodes of any quantity or position, such as four electrodes applying interferential stimulation.Type: ApplicationFiled: August 9, 2021Publication date: September 28, 2023Inventor: Eduard MAIBERG
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Publication number: 20230302278Abstract: A respiration implant system for an implanted patient with impaired breathing includes laryngeal stimulating electrodes that are configured to interface with left and right posterior cricoarytenoid muscles (PCAM) of a patient larynx to deliver respiration pacing signals to the PCAM to promote patient breathing. And a pacing processor is configured to generate the respiration pacing signals to alternatingly stimulate the left and right PCAM one at a time so as to always have one of the left and right PCAM in an unstimulated resting state.Type: ApplicationFiled: May 30, 2023Publication date: September 28, 2023Inventors: Markus Oberparleiter, Hooman Sedghamiz
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Publication number: 20230302279Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: April 11, 2023Publication date: September 28, 2023Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: Ivan Osorio
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Publication number: 20230302280Abstract: Implantable electrodes with power delivery wearable for treating sleep apnea, and associated systems and methods are disclosed herein. A representative system includes non-implantable signal generator worn by the patient and having an antenna that directs a mid-field RF power signal to an implanted electrode. The implanted electrode in turn directs a lower frequency signal to a neural target, for example, the patient's hypoglossal nerve. Representative signal generators can have the form of a mouthpiece, a collar or other wearable, and/or a skin-mounted patch.Type: ApplicationFiled: May 31, 2023Publication date: September 28, 2023Inventors: Richard W. O'Connor, Walter Joseph Stevens, Timothy A. Fayram
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Publication number: 20230302281Abstract: In one example, the disclosure describes a method comprising receiving, by processing circuitry, information indicative of one or more evoked compound action potential (ECAP) signals. The one or more ECAP signals are sensed by at least one electrode carried by a medical lead. The processing circuitry determining that at least one characteristic value of the one or more ECAP signals is outside of an expected range. Responsive to determining that the at least one characteristic value of the one or more ECAP signals is outside of the expected range, the processing circuitry performs a lead integrity test for the medical lead.Type: ApplicationFiled: April 27, 2023Publication date: September 28, 2023Inventors: Jiashu Li, Duane L. Bourget, Kristin N. Hageman, Hank Bink
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Publication number: 20230302282Abstract: Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.Type: ApplicationFiled: April 28, 2023Publication date: September 28, 2023Applicants: Synchron Australia Pty Limited, The University of MelbourneInventors: Nicholas Lachlan OPIE, Thomas James OXLEY, Gil Simon RIND
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Publication number: 20230302283Abstract: A wearable device for facilitating neurophysiological treatment of a patient harboring an implanted neural stimulator is provided. The wearable device includes a transmitting antenna configured to accept one or more input signals and to transmit one or more electromagnetic signals to a neural stimulator that is implanted in a patient's body. The wearable device further includes a control circuitry configured to provide the one or more input signals to the transmitting antenna. The wearable device further includes a battery that provides electrical power to at least the control circuitry. The wearable device is configured to be worn outside the patient's body.Type: ApplicationFiled: February 17, 2023Publication date: September 28, 2023Inventors: Laura Tyler Perryman, Elizabeth Greene, Chad Andresen
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Publication number: 20230302284Abstract: Disclosed herein is an implantable medical device including a housing, a header, a connector port, and a collet assembly. The header can be arranged with the housing. The connector port can be arranged within the header and configured to couple an implantable lead to the header. The collet assembly can be arranged within the connector port and configured to frictionally engage a portion of the implantable lead and to secure the implantable lead with the header in response to insertion of the portion of the implantable lead into the connector port.Type: ApplicationFiled: June 1, 2023Publication date: September 28, 2023Inventors: James M. English, Moira B. Sweeney, Trey H. Achterhoff, Benjamin J. Haasl, Robert A. Jones, Daniel J. Foster
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Publication number: 20230302285Abstract: A biostimulator, such as a leadless pacemaker, including a header assembly having an electrical feedthrough assembly incorporating a helix mount, is described. The header assembly includes a fixation element mounted on the helix mount. The helix mount is mounted on a flange of the electrical feedthrough assembly, and thus, the fixation element can attach the leadless biostimulator to a target tissue. An electrode of the electrical feedthrough assembly is mounted within the flange to deliver a pacing impulse to the target tissue. A ceramic portion of the helix mount is disposed between the flange and the electrode to block an electrical path between the electrode and the flange. Accordingly, the helix mount both retains the fixation element on the leadless biostimulator and electrically isolates the flange and electrode components of the electrical feedthrough. Other embodiments are also described and claimed.Type: ApplicationFiled: May 12, 2023Publication date: September 28, 2023Inventors: Bei Ning Zhang, Brett C. Villavicencio, Perry Li
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Publication number: 20230302286Abstract: A kit-of-parts for initiating an action by an active implantable medical device (AIMD) (1) implanted in a body of a patient triggered by an external triggering unit (11) located outside the body of the patient is provided. The kit-of-parts including, (A) the external triggering unit (11) including an external emitter (12) which includes one or more sources of light (12L) configured for emitting an optical starting signal (10), and (B) the AIMD (1) including an encapsulation unit (1e) defining an inner volume containing an action trigger configured for initiating an action by the AIMD (1), upon reception of the optical starting signal (10) from the external triggering unit (11). The action trigger is an optical action trigger (2) includes one or more photodetectors (2pv) facing a transparent wall portion (1t) and configured for transforming the optical starting signal (10) into an electrical signal to initiate the action by the AIMD.Type: ApplicationFiled: November 10, 2020Publication date: September 28, 2023Applicant: Synergia MedicalInventors: Pascal Doguet, Yoan Botquin, Jérôme Garnier
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Publication number: 20230302287Abstract: A rechargeable medical implant system for sacral stimulation therapy. The device includes a rechargeable power source that wireless charges via an external portable charger device having an audio transducer operably coupled with associated circuitry configured to provide audio feedback to assist the patient in recharging the neurostimulator device. The audio feedback includes two alerts where a first audio alert to indicate that the external charger device is aligned and that coupling between the wireless transmitting unit and the wireless receiving unit has occurred a second audio alert that indicates that the implantable neurostimulator device is fully charged, wherein the second audio alert is different from the first audio alert.Type: ApplicationFiled: April 14, 2023Publication date: September 28, 2023Applicant: Axonics, Inc.Inventors: Guangqiang JIANG, Dennis SCHROEDER, Raymond W. COHEN
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Publication number: 20230302288Abstract: A feedthrough assembly for an implantable medical device includes a ferrule, an inner conductor, and an insulating core. The ferrule has a lumen. The inner conductor extends through the lumen of the ferrule. The inner conductor has a first material composition. The insulating core is disposed within the lumen of the ferrule and separates the inner conductor from the ferrule. The insulating core has a second material composition that is different from the first material composition of the inner conductor. A coefficient of thermal expansion (CTE) of the inner conductor is no less than the CTE of the insulating core. The inner conductor is bonded to the insulating core to form a glass-to-metal seal between the inner conductor and the insulating core.Type: ApplicationFiled: May 31, 2023Publication date: September 28, 2023Inventor: Xiaofei Jiang
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Publication number: 20230302289Abstract: A transducer apparatus for delivering tumor treating fields to a subject’s body, the transducer apparatus including: an array of electrode elements, the array configured to be positioned over the subject’s body with a face of the array facing the subject’s body; wherein, when viewed from a direction perpendicular to the face of the array, an outer perimeter of the array substantially tracing the electrode elements has a shape including: at least one convex edge portion protruding away from a centroid of the array; and at least one concave edge portion recessed toward the centroid of the array.Type: ApplicationFiled: March 21, 2023Publication date: September 28, 2023Applicant: Novocure GmbHInventors: Noa HALAVEE, Shalom STRAUSS
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Publication number: 20230302290Abstract: There is provided a phototherapy apparatus, in which the therapeutic light is delivered through or in proximity to one or more massage components. The massage component provides mechanical massage to the subject biological tissue and modifies the properties of the subject tissue in thickness, density, etc. to facilitate the absorption of the therapeutic light and enhance the effect of the phototherapy procedure.Type: ApplicationFiled: May 22, 2023Publication date: September 28, 2023Inventors: Brian Pryor, Sean Xiaolu Wang
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Publication number: 20230302291Abstract: This treatment support system (100) is provided with an irradiation unit (10) for irradiating a medical agent (102) administered to a subject of a cancer subject (101) with therapeutic light in treatment for killing a cancer cell by irradiating the medical agent with the therapeutic light, a light detection unit (30) for detecting fluorescence excited by the therapeutic light, a control unit (51), and a display unit (60). The control unit (51) includes a signal acquisition unit (51a) for acquiring a fluorescence signal, an analysis processing unit (51c) for generating the analysis image (203) that displays a treatment progress distribution for each region of the treatment site based on a change along time series of the fluorescence signal, and an image output unit (51d) for outputting the analysis image (203).Type: ApplicationFiled: February 24, 2021Publication date: September 28, 2023Inventors: Akihiro ISHIKAWA, Masumi KAWAI
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Publication number: 20230302292Abstract: Methods and systems one or more for performing intra-luminal ultraviolet therapy for treating and/or ameliorating a gastrointestinal tract inflammation and/or infection are provided. In one example, a light delivery catheter may include a light emitting portion and non-illuminating portion, wherein the light emitting portion may include one or more UV transparent balloons. In some examples, the UV light source is configured to emit narrow-band light having wavelengths in a range between 335 nm and 349 nm.Type: ApplicationFiled: August 13, 2021Publication date: September 28, 2023Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed
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Publication number: 20230302293Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an antiinflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: May 23, 2023Publication date: September 28, 2023Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Publication number: 20230302294Abstract: Dermatological systems and methods for providing a therapeutic laser treatment wherein the magnitude of heat power or energy applied to a target skin area via a therapeutic laser pulse is based on the magnitude of cooling power or energy applied to the target skin area during a cooling of the skin prior to treatment with one or more therapeutic laser pulses.Type: ApplicationFiled: October 23, 2022Publication date: September 28, 2023Applicant: CUTERA, INC.Inventors: Michael A. KARAVITIS, Amogh KOTHARE, Soenke A. MOELLER
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Publication number: 20230302295Abstract: Dermatological systems and methods for reducing pain associated with treating of skin with high-fluence therapeutic laser light including applying a first agent to solubilize oils, removing the first agent and oil to reduce the level of oil in the skin by at least 85%, rehydrating the skin after the oil removal, applying a contact cooling element including a cooling window to the area within five minutes of rehydrating the skin, cooling the skin from a first to a second temperature, and applying at least one high-fluence therapeutic laser pulse to the skin.Type: ApplicationFiled: October 24, 2022Publication date: September 28, 2023Applicant: CUTERA, INC.Inventors: Michael A. KARAVITIS, Amogh KOTHARE
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Publication number: 20230302296Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.Type: ApplicationFiled: May 15, 2023Publication date: September 28, 2023Applicant: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.Inventors: Gui LI, Yin TANG, Shaoqiang YE, Juan LIU
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Publication number: 20230302297Abstract: Techniques are described that use surface camera imaging data combined with other information to describe how a patient is moving in 4D. Intrabody imaging data, such as from CT images, and surface camera imaging data, such as from surface imaging cameras, can be acquired. A system can generate a model relating the intrabody imaging data having a three-dimensional (3D) patient representation to a two-dimensional (2D) surface patient representation. During a particular treatment fraction session, the system can obtain surface camera imaging data and use the surface camera imaging data and the model to calculate a 3D patient representation during the particular treatment fraction session. In this manner, surface camera imaging data can drive the model to provide motion management during (or before or after) a treatment session so that the 3D state of a patient is known at any given moment during (or before or after) a treatment session.Type: ApplicationFiled: August 17, 2021Publication date: September 28, 2023Inventors: Martin Emile Lachaine, Tony Falco
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Publication number: 20230302298Abstract: Generating a robust radiotherapy treatment plan for a treatment volume, defined using a plurality of voxels, of a subject. A first and at least one second image of the treatment volume are received. A distribution of mapped doses in the first image is generated by mapping a dose defined in the at least one second image to the first image using image registration. An optimization problem is defined using at least one optimization function for a total dose, related to the radiotherapy treatment. At least one optimization function value is calculated based on at least two mapped doses in the distribution of mapped doses in the first image. A radiotherapy treatment plan is generated by optimizing the at least one optimization function value evaluated by taking into account the at least two mapped doses in the distribution of mapped doses.Type: ApplicationFiled: March 20, 2023Publication date: September 28, 2023Inventors: Ivar BENGTSSON, Albin FREDRIKSSON
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Publication number: 20230302299Abstract: The invention is to provide a radiation therapy system capable of widening a radiation irradiation range to a patient without increasing a burden on a structure. The radiation therapy system includes: a radiation source; a rotation mechanism that supports the radiation source and rotates the radiation source around an isocenter; a couch that places a therapy target site of a patient at the isocenter; a head swing mechanism that is disposed between the radiation source and the rotation mechanism and that swings an irradiation axis of a radiation emitted from the radiation source by swinging the radiation source; and a control unit that controls the radiation source, the rotation mechanism, and the head swing mechanism.Type: ApplicationFiled: May 22, 2023Publication date: September 28, 2023Inventors: Shuji KANEKO, Kunio TAKAHASHI
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Publication number: 20230302300Abstract: Apparatus, systems, and methods associated with microfabricated ultrasound transducer array for neural stimulation are applicable in a variety of applications. Microfabricated micro-scale ultrasound transducers can be integrated with microelectrode arrays for high spatial stimulation of neurons. Ultrasound stimulation of neurons can be combined with electrical recording to monitor neural activity. Such high spatial stimulation devices can be implemented for in-vitro and in-vivo applications. In-vivo applications can include high frequency ultrasound transducers incorporated into brain probes that are implanted at a specific area in the brain, where the high frequency ultrasound transducer can stimulate neurons at that target location.Type: ApplicationFiled: September 13, 2021Publication date: September 28, 2023Inventor: Nathan Morrow Jackson
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Publication number: 20230302301Abstract: Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.Type: ApplicationFiled: May 4, 2023Publication date: September 28, 2023Inventors: Paul Sobotka, Neil Barman
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Publication number: 20230302302Abstract: A method of reducing the appearance of fine lines or wrinkles, firming skin, or hydrating skin is disclosed. The method includes topically applying to skin in need thereof a composition comprising palmitoyl tetrapeptide 7, water, glycerin, butylene glycol, disodium EDTA, citric acid, sodium lactate, and a carbomer. Topical application of the composition to the skin reduces the appearance of fine lines or wrinkles, firms the skin, or hydrates the skin.Type: ApplicationFiled: May 19, 2023Publication date: September 28, 2023Inventors: Dawn BURKE-COLVIN, Michelle HINES, David GAN
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Publication number: 20230302303Abstract: The invention comprises a shampoo apparatus and method of use thereof, comprising: putting a shampoo and carbon dioxide into a container, at least a portion of the carbon dioxide comprising at least one of a solid form and a liquid form; sealing the container; warming the carbon dioxide by at least fifty degrees Fahrenheit to form a carbon dioxide gas, the carbon dioxide gas at least partially dissolved in the shampoo, the carbon dioxide gas comprising a concentration of one-half to ten percent of the shampoo by mass; and pressurizing the container to a pressure exceeding sixty pounds per square inch, such as where a headspace forms in the container, the headspace comprising the carbon dioxide at a concentration greater than one thousand parts per million, where the pressurized carbon dioxide yields a propulsive force, a foam expansion function, and a cleaning function.Type: ApplicationFiled: March 30, 2022Publication date: September 28, 2023Inventor: Nyangenya Maniga
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Publication number: 20230302304Abstract: Portable vessels, regulators, apparatus, and methods for storing fluids under pressure are disclosed.Type: ApplicationFiled: August 20, 2021Publication date: September 28, 2023Inventor: Jarvis B. Jenkins
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Publication number: 20230302305Abstract: A respirator comprising: an air supply unit arranged to deliver air at its output; headgear comprising a cradle for interfacing with a user’s head, and a face covering from within which the user breathes; a tube to receive air from the air supply unit; and a vibration decoupler, provided between the air supply unit and the head gear interface component, such that in use vibrations from the air supply and tube are reduced.Type: ApplicationFiled: July 14, 2021Publication date: September 28, 2023Applicant: BAE SYSTEMS plcInventors: Derek Scholes, Alexander Grint, Michael Fraser, Paul Douglas
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Publication number: 20230302306Abstract: A facial guard system configured to be worn on a person's head, in front of the face, has a barrier with a peripheral edge that cooperates with a base that acts as a seal between the barrier and the person's face to create an enclosed space around the facial orifices into which air may flow into only through a submaxillary filtered opening and one or more additional filtered openings defined in the barrier and/or base. The base includes a conforming section that creates a continuous seal across the wearer's forehead, down along the zygoma, cheek, and jaw on each side of the wearer's face, and then to or under the wearer's chin. The submaxillary filtered opening may include an integrated filter and fan unit for blowing air into enclosed spaced directed toward the nostrils of a person wearing the facial guard system.Type: ApplicationFiled: May 18, 2023Publication date: September 28, 2023Inventor: David T.W. Chiu
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Publication number: 20230302307Abstract: A respirator comprising: an air supply unit arranged to deliver air at its output; headgear comprising a cradle for interfacing with a user's head, and a face covering from within which the user breathes; a tube to receive air from the air supply unit; and an interface component to receive air from the tube and to deliver said air within the face covering, wherein the interface component provides a frame for supporting the face covering, and comprises an overhead branch and a forehead branch, wherein the overhead branch comprises one or more bleed holes, such that in use vibrations from the air supply and tube are reduced. Components of the respirator and related methods are also described.Type: ApplicationFiled: July 14, 2021Publication date: September 28, 2023Applicant: BAE SYSTEMS plcInventors: Derek Scholes, Simon Churchman, Paul Douglas, Simon Alker
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Publication number: 20230302308Abstract: A web harness system includes a sub-pelvic support portion. A leg harness portion is connected to the sub-pelvic support portion. The leg harness portion including: a first leg extension connected to a first portion of the sub-pelvic support portion; a second leg extension connected to a second portion of the sub-pelvic support portion; a right leg adjustment belt connected to the first leg extension; and a left leg adjustment belt connected to the second leg extension.Type: ApplicationFiled: March 28, 2022Publication date: September 28, 2023Inventors: Samuel Raymond Andrade, John F. Aldrich
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Publication number: 20230302309Abstract: A fall-protection safety harness with first and second ventral straps and with a ventral buckle that is at least generally aligned with a sagittal plane of the user, wherein the ventral buckle comprises first and second buckle portions mounted on the first and second ventral straps, respectively.Type: ApplicationFiled: August 13, 2021Publication date: September 28, 2023Inventors: Michael T. Weiss, Nathan W. Safe, Stephen D. Shaver
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Publication number: 20230302310Abstract: A connection arrangement for use with a wearable body harness includes a first connector having a first body component, a second body component, and an attachment element connected to each other by a rod having a longitudinal axis. The connection arrangement further includes a second connector removably connectable to the first connector. Each of the first body component, the second body component, and the attachment element are independently movable relative to each other about the longitudinal axis of the rod. The first connector and the second connector are removably connectable to each other via a locking and release mechanism between a first, locked configuration, where the first connector and the second connector are connected to each other, and a second, unlocked configuration, where the first connector and the second connector are disconnected from each other.Type: ApplicationFiled: May 2, 2023Publication date: September 28, 2023Inventors: Michael D. Monahan, Mark Hall, Eduardo José Ferreira Dodge
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Publication number: 20230302311Abstract: A device (1-1b) for rescuing a person (33) from a wind turbine (5), which comprises a parachute and a harness (9; 9b), which can be or is connected to the parachute, and which can be donned by the person to be rescued (33). Advantageously, a static line (2) is provided for connecting the rescue device (1-1b) to the wind turbine (5). Advantageously, rescuing maintenance personnel in an evacuation by jumping from the nacelle or an opening in the wind turbine is possible.Type: ApplicationFiled: March 22, 2023Publication date: September 28, 2023Inventor: Stefan Ertler