Patents Issued in February 1, 2024
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Publication number: 20240038298Abstract: Josephson junction based memory devices and methods for their use are described herein. An example Josephson junction based memory device includes a plurality of superconducting loops. Each superconducting loop includes at least one Josephson junction. The plurality of superconducting loops are electrically coupled. The plurality of superconducting loops include a plurality of input loops, a plurality of readout loops, and at least one shared loop. The plurality of superconducting loops are configured to store or annihilate magnetic flux quanta in one or more of the superconducting loops in response to a combination of control signals and single flux quantum (SFQ) pulses.Type: ApplicationFiled: July 27, 2022Publication date: February 1, 2024Inventors: Henry Luo, Anna Yurievna Herr, Quentin Paul Herr
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Publication number: 20240038299Abstract: The present disclosure generally relates to combinations of resistive change elements and resistive change element arrays thereof. The present disclosure also generally relates to combinational resistive change elements and combinational resistive change element arrays thereof. The present disclosure additionally generally relates to devices and methods for programming and accessing combinations of resistive change elements. The present disclosure further generally relates to devices and methods for programming and accessing combinational resistive change elements.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Applicant: Nantero, Inc.Inventors: Jia Luo, Lee E. Cleveland, Ton Yan Tony Chan
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Publication number: 20240038300Abstract: A memory device includes a plurality of select lines, a plurality of word lines, an array of memory cells, a bitline, and a resistance device. The array of memory cells includes multiple rows and multiple columns. The bitline is structured to receive a current in a read operation, causing a value stored in a selected memory cell to be readable when a select line and a word line that interest the selected memory cell are selected. The resistance device has a first terminal and a second terminal. The first terminal is coupled to the select lines, and the second terminal is coupled to ground. The resistance device is structured to bias, in the read operation, word lines of unselected memory cells in a column of a selected memory cell to a determined negative voltage.Type: ApplicationFiled: September 29, 2022Publication date: February 1, 2024Inventors: Shishir Kumar, Vinay Kumar
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Publication number: 20240038301Abstract: Methods, systems, and devices for memory cell read operation techniques are described. A memory device may determine a starting voltage for a second phase of a read operation for a set of memory cells which may have a different magnitude than a magnitude of a starting voltage of a first phase of the read operation. For example, the memory device may use an ending voltage of the first phase to determine the starting voltage for the second phase. In some cases, the starting voltage for the second phase may correspond to a difference of a voltage offset and the ending voltage of the first phase. As part of the second phase of the read operation, the memory device may apply a sequence of voltages to the set of memory cells in accordance with the determined starting voltage of the second phase.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Inventors: Riccardo Muzzetto, Francesco Mastroianni, Ferdinando Bedeschi, Nevil N. Gajera
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Publication number: 20240038302Abstract: A semiconductor device may include: a plurality of first conductive lines extending in a first direction; a plurality of second conductive lines extending in a second direction; a plurality of memory cells respectively disposed at intersection regions between the first conductive lines and the second conductive lines; and a layer formed between each memory cell and at least one of a first conductive line and an intersecting second conductive line between which the memory cell is located, wherein the layer includes a conductive material that is capable of generating a void to create an open circuit by electromigration when a current applied to the layer through the first conductive line and the second conductive line exceeds a threshold current and is electrically conductive when the current applied to the layer through the first conductive line and the second conductive line is below the threshold current.Type: ApplicationFiled: January 25, 2023Publication date: February 1, 2024Inventor: Jeong Hwan SONG
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Publication number: 20240038303Abstract: A filter basket for use with a coffee machine includes a valve selectively operable by a lever of the coffee machine to allow liquid coffee to exit the filter basket. The valve is spring biased to a closed position preventing liquid coffee from exiting the filter basket.Type: ApplicationFiled: October 9, 2023Publication date: February 1, 2024Inventors: Richard Harrod, Alex Ming Duk Leung
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Publication number: 20240038304Abstract: A memory device, and an operating method of the memory device, includes a first memory block and a second memory block each including a plurality of memory cells. The memory device also includes a voltage generator for applying operating voltages to first global lines, selectively applying a positive voltage to global select lines included in second global lines while the operating voltages are applied, and applying a ground voltage to the other global lines except the global select lines among the second global lines. The memory device further includes a row decoder for turning on first pass switches between first local lines connected to the first memory block and the first global lines, and turning off second pass switches between second local lines connected to the second memory block and the second global lines.Type: ApplicationFiled: December 9, 2022Publication date: February 1, 2024Applicant: SK hynix Inc.Inventor: Nam Cheol JEON
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Publication number: 20240038305Abstract: A semiconductor storage device includes a first memory cell electrically connected to a first bit line and a first word line, a second memory cell electrically connected to a second bit line and the first word line, and a first circuit configured to supply voltages to the first word line. During a reading operation to read a page of memory cells including the first memory cell and the second memory cell, the first circuit supplies a first voltage to the first word line while the first memory cell is selected as a read target during a first time period, and supplies a second voltage greater than the first voltage to the first word line while the second memory cell is selected as a read target during a second time period that is different from the first time period, and directly thereafter, supplies the first voltage to the first word line.Type: ApplicationFiled: October 12, 2023Publication date: February 1, 2024Inventors: Mai SHIMIZU, Koji KATO, Yoshihiko KAMATA, Mario SAKO
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Publication number: 20240038306Abstract: There are provided a memory device and an operating method of the memory device. The memory device includes: a first select transistor, a plurality of memory cells, and a second select transistor, connected between a source line and a bit line; and a peripheral circuit for performing a pre-program operation on the plurality of memory cells and then performing an erase operation on the plurality of memory cells. In the pre-program operation, the peripheral circuit is configured to apply a program voltage to word lines that are connected to the plurality of memory cells corresponding to a channel that has been floated.Type: ApplicationFiled: January 26, 2023Publication date: February 1, 2024Applicant: SK hynix Inc.Inventor: Hee Youl LEE
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Publication number: 20240038307Abstract: A portable communications device is adapted with a controlled self-erasing option to programmably store user content and key data based on a desired limited lifespan for such data. This allows for improved security in the event the device is misplaced or lost as the onboard user data eventually becomes physically destroyed and unreadable to a third party without requiring a remote access destruction capability.Type: ApplicationFiled: October 7, 2023Publication date: February 1, 2024Applicant: JONKER LLCInventors: John Nicholas Gross, David K. Y. Liu
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Publication number: 20240038308Abstract: A controller is adapted for a portable communications device, such as a smartphone, with a user controlled self-erasing option to programmably store data locally only for limited periods of time until it can be uploaded to a cloud device. This allows for improved data storage management on the device including increased storage capacity.Type: ApplicationFiled: October 7, 2023Publication date: February 1, 2024Applicant: JONKER LLCInventors: John Nicholas Gross, David K. Y. Liu
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Publication number: 20240038309Abstract: A memory device may include a memory block and a control circuit. The memory block may include a first sub-block and a second sub-block that are connected between a common source line and a plurality of bit lines and may be vertically stacked. The control circuit may be configured to select any one of the common source line and the plurality of bit lines as a transmission path of an erase voltage based on positions of the first sub-block and the second sub-block, and perform erase operations on the first sub-block and the second sub-block in units of sub-blocks.Type: ApplicationFiled: October 10, 2023Publication date: February 1, 2024Inventors: Jinyoung KIM, Sehwan PARK, Ilhan PARK, Youngdeok SEO, Dongmin SHIN
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Publication number: 20240038310Abstract: Techniques for protecting non-volatile memory (NVM) from power cycle interruptions during memory operations are disclosed. A power management integrated circuit (PMIC) coupled to a memory circuit with NVM implements the various techniques disclosed. When a power reset signal is asserted to a PMIC, the PMIC may delay initiation of the power reset cycle when it detects that the NVM coupled to the PMIC is active to prevent corruption of the NVM by the power reset cycle. The PMIC may detect the activity level of the NVM based on an activity output signal that indicates whether the NVM is active (e.g., programming or erasing) or inactive.Type: ApplicationFiled: July 26, 2022Publication date: February 1, 2024Inventors: John J. Sullivan, James M. Hollabaugh, Jason W. Brinsfield, Calvin M. Ryan, Andreas Adler
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Publication number: 20240038311Abstract: A method includes designating a first subset of non-volatile memory with a first reliability designation, designating a second subset of non-volatile memory blocks with a second reliability designation, configuring the first subset of non-volatile memory blocks and the second subset of non-volatile memory blocks in a first verification mode, writing data to first subset of non-volatile memory blocks and the second subset of non-volatile memory blocks in the absence of write verification.Type: ApplicationFiled: July 27, 2022Publication date: February 1, 2024Inventors: Yu-Chung Lien, Ankit V. Vashi, Zhenming Zhou, Jung Sheng Hoei
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Publication number: 20240038312Abstract: A memory device includes: a plurality of page buffers connected a plurality of bit lines and configured to selectively precharge the bit lines, and a control circuit configured to: perform a first verify operation by applying a precharge voltage to a first bit line among the bit lines according to program data and by applying a first verify voltage to a selected word line, perform a second verify operation, after the first verify operation, by applying the precharge voltage to a second bit line not overlapping the first bit line and by applying a second verify voltage to the selected word line, and perform at least one of an operation of floating the first bit line and an operation of applying the precharge voltage according to a threshold voltage of a memory cell connected to the first bit line during the second verify operation.Type: ApplicationFiled: December 2, 2022Publication date: February 1, 2024Inventor: Soo Yeol CHAI
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Publication number: 20240038313Abstract: Disclosed herein are methods, apparatuses and systems related to adjusting operation of memory dies according to reliability measures determined in real-time. The apparatus may be configured to determine the reliability measures based on (1) initiating and completing a programming operation within respective timings following an erase operation and (2) reading the programmed data within a window from completing the programming operation.Type: ApplicationFiled: July 28, 2022Publication date: February 1, 2024Inventor: Meng Wei
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Publication number: 20240038314Abstract: One-time programmable (OTP) bit-cell for an integrated circuit (IC) that includes an OTP element, such as a fuse or antifuse, coupled in electrical series with a selector that comprises a Schottky junction. The selector may comprise a metal-semiconductor-metal (MSM) material stack operable as transient voltage suppression (TVS) device that experiences electrical breakdown at a voltage below a programming voltage of the OTP element. In response to a programming voltage, the MSM stack may breakdown and pass a transient current sufficient for programming the OTP element. In response to a lower (e.g., read) voltage, the MSM stack may breakdown and pass a transient current insufficient for programming, but sufficient to sense a state of the OTP element. In response to an even lower (e.g., half-read) voltage, the MSM stack may present a very high OTP bit-cell input impedance, reducing leakage and/or sneak path currents within an array of such bit-cells.Type: ApplicationFiled: August 1, 2022Publication date: February 1, 2024Applicant: Intel CorporationInventor: Yao-Feng Chang
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Publication number: 20240038315Abstract: An apparatus is provided that includes a block including a word line coupled to a plurality of memory cells, and a control circuit coupled to the word line. The control circuit is configured to program the plurality of memory cells by applying program pulses to the word line in a plurality of program loops, determining a first count of a number of the program loops used to complete programming a first subset of the plurality of memory cells to a first programmed state, first comparing the first count to a corresponding first lower limit and a corresponding first upper limit, and determining whether programming the plurality of memory cells has failed based on a result of the first comparing step.Type: ApplicationFiled: July 26, 2022Publication date: February 1, 2024Applicant: SanDisk Technologies LLCInventors: Yi Song, Sarath Puthenthermadam, Jiahui Yuan
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Publication number: 20240038316Abstract: A memory device includes a memory array including wordlines and at least one string of cells. Each cell of the at least one string of cells is addressable by a respective wordline. The memory device further includes control logic, operatively coupled to the memory array, to perform operations including generating gate-induced drain leakage (GIDL) with respect to the at least one string of cells, and causing a grounding voltage to be applied to a set of wordlines to ground each cell of the at least one string of cells addressable by each wordline of the set of wordlines. The grounding voltage applied to the set of wordlines enables transport of positive charge carriers generated by the GIDL. In some embodiments, the positive charge carriers neutralize a buildup of negative charge carriers generated during a seeding phase of a program refresh operation.Type: ApplicationFiled: July 18, 2023Publication date: February 1, 2024Inventors: Huai-Yuan Tseng, Eric N. Lee, Akira Goda, Kishore Kumar Muchherla, Tomoharu Tanaka
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Publication number: 20240038317Abstract: A data coding device may include a raw data storage configured to store raw data of which the total number of bits is 2N, a previous data storage configured to store previous data output before the raw data, a counter configured to count the number of reference data bits included in the raw data, and a data output configured to invert and output the raw data according to a comparison result with the previous data when the number of reference data bits included in the raw data is N, and invert and output the raw data according to the number of reference data bits included in the raw data when the number of reference data bits included in the raw data is not N.Type: ApplicationFiled: January 9, 2023Publication date: February 1, 2024Inventors: Ie Ryung PARK, Dong Sop LEE
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Publication number: 20240038318Abstract: A read-write method includes: sequentially writing, in a first direction, a code word obtained by information-bit encoding into a target memory cell in each layer of memory cell array in the three-dimensional memory; randomly reading the target memory cell in each layer of memory cell array, or sequentially reading the target memory cell in each layer of memory cell array in a second direction; and determining an LLR value of a current target memory cell according to a storage time corresponding to the current target memory cell when reading, a threshold voltage partition corresponding to the current target memory cell when reading, a comprehensive distribution state corresponding to the current target memory cell when reading, and a pre-established LLR table, so as to perform a soft decoding operation on the code word in the current target memory cell based on the LLR value of the current target memory cell.Type: ApplicationFiled: November 25, 2020Publication date: February 1, 2024Inventors: Qi Wang, Yiyang Jiang, Qianhui Li, Zongliang Huo, Tianchun Ye
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Publication number: 20240038319Abstract: A memory system including a memory device that receives a plurality of signals including a post package repair (PPR) command from a host, wherein the memory device includes a memory cell array including a plurality of memory cells connected to a plurality of word lines and a plurality of bit lines, a plurality of redundancy memory cells connected to one or more redundancy word lines and the plurality of bit lines, and anti-fuse memory cells, and a PPR control circuit that transmits to the host whether a PPR operation on a defective memory cell of the memory cell array has passed.Type: ApplicationFiled: July 17, 2023Publication date: February 1, 2024Inventors: NAMHYUNG KIM, DAEJEONG KIM, DOHAN KIM, DEOKHO SEO, JAEIN SONG, INSU CHOI
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Publication number: 20240038320Abstract: Implementations described herein relate to performing a memory built-in self-test and indicating a status of the memory built-in self-test using a data mask inversion (DMI) bit. A memory device may read one or more bits, associated with a memory built-in self-test, that are stored in a mode register of the memory device. The memory device may identify a first DMI bit of the memory device that is associated with indicating a status of the memory built-in self-test and a second DMI bit of the memory device that is not associated with indicating the status of the memory built-in self-test. The memory device may set the first DMI bit to a first value based on the one or more bits indicating that the memory built-in self-test is enabled. The memory device may perform the memory built-in self-test based on setting the first DMI bit to the first value.Type: ApplicationFiled: July 28, 2022Publication date: February 1, 2024Inventor: Scott E. SCHAEFER
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Publication number: 20240038321Abstract: An electronic device, such as a memory device, may include various circuit components. The electronic device may also include one or more voltage testing circuits to determine whether signals of one or more of the circuit components are within acceptable voltage ranges of the respective circuit components. Systems and methods are described to improve correct voltage measurement of the received signals by a voltage testing circuit. In particular, multiple supply voltage levels are provided to different components of the voltage testing circuit to provide a sufficient headroom voltage gap between received signals and the supply voltages. For example, some active circuits (e.g., operational amplifiers) of the voltage testing circuit may receive a higher supply voltage of the electronic device compared to one or more other circuits of the voltage testing circuit.Type: ApplicationFiled: July 26, 2022Publication date: February 1, 2024Inventors: Subhasis Sasmal, Dong Pan
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Publication number: 20240038322Abstract: Apparatuses, methods, and systems for performing sense operations in memory are disclosed. The memory can have a group of memory cells, and circuitry can be configured to perform a sense operation on the group, wherein performing the sense operation includes performing a first sense operation in a first polarity on the group of memory cells to determine a quantity of the memory cells of the group that are in a particular data state, and performing a second sense operation in a second polarity on the group of memory cells to determine a data state of the memory cells of the group. The second polarity is opposite the first polarity, and the second sense operation is a count-based sense operation that uses the determined quantity of memory cells in the particular data state as a counting threshold to determine the data state of the memory cells of the group.Type: ApplicationFiled: July 26, 2022Publication date: February 1, 2024Inventors: Michele Maria Venturini, Umberto Di Vincenzo, Ferdinando Bedeschi, Riccardo Muzzetto, Christophe Vincent Antoine Laurent, Christian Caillat
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Publication number: 20240038323Abstract: Systems and methods of determining pre-quantitation attributes of biological samples using post-quantitation attributes of those samples is disclosed. By altering a set of biological samples in a measurable way before running the set through an instrument (e.g., a mass spectrometer), a model can be developed that enables determination of the unknown pre-quantitation attributes in other biological samples as a function of post-quantitation attributes.Type: ApplicationFiled: October 13, 2023Publication date: February 1, 2024Applicant: Liquid Biosciences, Inc.Inventors: Patrick Lilley, Beau Walker, Michael John Colbus
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Publication number: 20240038324Abstract: The present invention provides a knowledge reuse-based method and system for predicting a cell concentration in a fermentation process. The method includes: constructing a cell concentration soft sensor universal model in a fermentation process; acquiring and preprocessing process data of a fermentation stage A; determining a cell concentration soft sensor model of the fermentation stage A; designing a cell concentration online soft sensor of a fermentation stage B; and predicting a cell concentration of the fermentation stage B according to the cell concentration online soft sensor of the fermentation stage B. The present invention resolves the problems of weak generalization of a cell concentration soft sensor model and high costs of establishing models for fermentation stages separately, thereby improving the prediction accuracy of a cell concentration soft sensor.Type: ApplicationFiled: July 11, 2023Publication date: February 1, 2024Inventors: Xiaoli LUAN, Xiaojing PING, Haiying WAN, Fei LIU
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Publication number: 20240038325Abstract: The application discloses a reverse virtual screening platform and method based on programmable quantum computing, the method includes the following steps: S1, for a given micromolecule and a target protein molecule, calculating a binding interaction graph of the given micromolecule and the target protein molecule on a computer according to different distances between pharmacophores; S2, encoding, according to an adjacency matrix of the binding interaction graph, the binding interaction graph into a quantum reverse virtual screening platform by decomposing the adjacency matrix; and S3, performing Gaussian boson sampling by the quantum reverse virtual screening platform. The reverse virtual screening platform and method based on programmable quantum computing provided by the present application are implemented by an optical quantum computer system based on a time domain.Type: ApplicationFiled: March 16, 2023Publication date: February 1, 2024Inventors: Shang YU, Zhipeng ZHONG, Liang XU, Jianshun TANG, Yitao WANG
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Publication number: 20240038326Abstract: A method (100) for characterizing a relevance of one or more genes or pathways to a disease of an individual, comprising: (i) obtaining (110) a phenotype profile for the individual, comprising phenotypic characteristics, and differential gene and protein expression information; (ii) identifying (120) one or more database of stored phenotype profiles similar to the individual phenotype profile; (iii) determining (130) a relevance of a genetic pathway to the individual phenotype profile, based at least in part on a similarity between the genetic pathway's known disease/phenotype associations and a phenotype profile of the individual; (iv) determining (140) a relevance of a gene to the individual phenotype profile, based at least in part on a similarity between the gene's known disease/phenotype associations and a phenotype profile of the individual; and (v) reporting (150) one or more genetic pathways and/or one or more genes most relevant to the individual phenotype profile.Type: ApplicationFiled: November 20, 2020Publication date: February 1, 2024Inventors: Yee Him CHEUNG, Jie Wu, Nevenka Dimitrova
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Publication number: 20240038327Abstract: This disclosure describes methods, non-transitory-computer readable media, and systems that can use a single executable file to run a single-cell multiomics analysis that (i) aligns multiomics reads with a reference genome and (ii) jointly filters cellular barcode sequences for cells based on feature-specific, single-cell read counts. To run such an assay, the disclosed systems identify transcriptomic reads and genomic reads for a sample, where such reads comprise different sets of cellular barcode sequences. In some cases, the disclosed systems further use separate invocations of a configurable processor to align the transcriptomic reads and genomics reads with a reference genome. Based on single-cell counts of aligned transcriptomic reads and aligned genomic reads for target nucleotide sequences, the disclosed systems select a subset of candidate cells corresponding to a subset of cellular barcode sequences.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Inventors: Igor Mandric, Sean Truong, Francesco Gavino Brundu
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Publication number: 20240038328Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.Type: ApplicationFiled: September 21, 2023Publication date: February 1, 2024Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
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Publication number: 20240038329Abstract: A method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a combination of a generative and a predictive model, training a phenotype prediction model based on experiential genotype vectors, training a genotype generation model based on sample genotype vectors, generating new genotype vectors, applying the phenotype prediction model to the new genotype vectors to generate scores, determining result genotypes based on a ranking of the available genotypes according to the scores, and generating a result based on the result genotypes, the result indicating one or more genetic constructs for testing.Type: ApplicationFiled: February 6, 2023Publication date: February 1, 2024Inventors: Eduardo Abeliuk, Andrés Igor Pérez Manríquez, Juan Andrés Ramírez Neilson, Diego Francisco Valenzuela Iturra
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Publication number: 20240038330Abstract: Disclosed is a method of analysing genetic data about an organism comprising receiving a plurality of input units. Each input unit comprises information about the association between genetic variants in a region of the genome and a target phenotype. One or more iterations are carried out comprising, for each variant, determining whether the variant is causal for the target phenotype. If the variant is causal, a sampled effect size is determined for each input unit based on the input units and correlations between the plurality of genetic variants in the region. The sampled effect size is non-zero for all of the input units. For each variant, a prediction effect size is determined for each input unit based on an average across the iterations of the sampled effect sizes for the input unit or of posterior effect sizes for the input unit calculated using the sampled effect sizes.Type: ApplicationFiled: November 26, 2021Publication date: February 1, 2024Applicant: GENOMICS PLCInventors: Rachel MOORE, Vincent Yann Marie PLAGNOL, Fernando RIVEROS-MCKAY, Michael WEALE, Daniel WELLS, Christopher Charles Alan Spencer
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Publication number: 20240038331Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.Type: ApplicationFiled: September 1, 2023Publication date: February 1, 2024Inventors: David BAKER, Neil KING, Jacob BALE, William SHEFFLER
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Publication number: 20240038332Abstract: A system and method that provides a process of genetically modifying algae or seaweeds in order to have their life cycle processes changed such that they grow in such a way that after a period of time they arrive at negative buoyancy causing the algae or seaweed to sink to the bottom of a body of water. The purpose of this is to cause the carbon or other elements in the algae or seaweed to be captured and deposited on the floor of the body of water where the carbon or other elements of the dead algae or seaweed is sequestered and are not released into the body of water nor the atmosphere for a long period of time. Furthermore, the genetic modification may be done in such a way that the targeted genetic characteristics are optimized and may not be passed to subsequent generations of the algae or seaweed. This process may occur in a computer virtual test environment, a controlled laboratory environment, or the natural environment.Type: ApplicationFiled: October 9, 2023Publication date: February 1, 2024Inventor: John McDevitt
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Publication number: 20240038333Abstract: The presently described techniques relate generally to configuration and use of a software platform that provides tools for users to store, arrange, and visualize genetic data, such as may be derived from a nucleic acid sequencing device. In addition, such a software platform may include one or more tools that allow a user to annotate genetic data with information available from external and/or internal genetic databases and to create custom reports based on such information. In practice, the software platform may be generic with respect to the sequencing device generating the sequence data, one or more upstream analytic packages, such as may perform variant identification or calling, and one or more external or internal data stores (e.g., knowledge bases or databases) used to access information about the sequence and/or variants identified therein.Type: ApplicationFiled: July 24, 2023Publication date: February 1, 2024Inventors: Sam Ng, Dylan Barfield, Jing Gao, Kevin P. Rhodes, Sachin Parikh, Akshay Kotadia, Kim Pelak
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Publication number: 20240038334Abstract: In a method for generating an image processing sequence, when selecting a learning set, a probability of selection of the learning set having a predetermined value, of a plurality of subject evaluation values corresponding respectively to two or more learning sets calculated in a previous routine, is increased.Type: ApplicationFiled: July 27, 2023Publication date: February 1, 2024Inventor: Hideaki KASAHARA
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Publication number: 20240038335Abstract: Systems and methods for detecting a subtype of a disease state and for determining the development of a resistance mechanism in a disease are disclosed. One method may include: receiving, at an input component of the system, a set of sequence reads associated with a nucleic acid sample; generating, using a processor of the system and via analysis of the set of sequence reads, methylation data; and analyzing, using the processor, the methylation data to identify the subtype of the disease state. Another method may include: obtaining methylation data from a targeted methylation sequencing assay, applying the methylation data to a trained machine learning model, and receiving an output indicating whether MRD is present in a test subject and/or whether a resistance mechanism has been developed by a disease. Other aspects are described and claimed.Type: ApplicationFiled: July 31, 2023Publication date: February 1, 2024Applicant: GRAIL, LLCInventors: Tracy NANCE, Joerg BREDNO, Oliver Claude VENN, Robert Abe Paine CALEF, Jennifer TOM
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Publication number: 20240038336Abstract: A method is provided for training a predicting cfDNA shedding model using a plurality of lesion and cfDNA datasets. A new cfDNA shedding sample and the plurality of lesion and cfDNA datasets are clustered to predict a shedding pattern. A diagnostic type is determined for a subsequent cfDNA shedding sample based on the predicted shedding pattern.Type: ApplicationFiled: July 26, 2022Publication date: February 1, 2024Inventors: Kahn Rhrissorrakrai, FILIPPO UTRO, Chaya Levovitz, Laxmi Parida
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Publication number: 20240038337Abstract: Presented herein are systems and methods for prediction of protein sequences, such as interfaces and/or other portions of custom biologics, e.g., for binding to target molecules. In certain embodiments, technologies described herein utilize graph-based neural networks to predict portions of protein/peptide structures of a custom biologic (e.g., a protein and/or peptide) that is being designed.Type: ApplicationFiled: June 29, 2023Publication date: February 1, 2024Inventors: Joshua Laniado, Julien Jorda, Matthias Maria Alessandro Malago, Thibault Marie Duplay, Mohamed El Hibouri, Lisa Juliette Madeleine Barel, Ramin Ansari
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Publication number: 20240038338Abstract: An apparatus for analyzing flow cytometry data for a fluid sample has a datastore that stores cytometry datasets, a computing system coupled to the datastore, marker pairs, a user interface coupled with the computing system, a data structure representing a bivariate coordinate system having an x-axis, a y-axis, and an area, and, event populations (an initial population and one or more subpopulations). Each cytometry dataset has a series of events about the fluid sample. Each event has parameter values associated with one of a scatter parameter and an antigen parameter. The computing system operates upon the cytometry datasets. Each marker pair has a first and a second parameter. The area has units (cluster and empty units).Type: ApplicationFiled: July 27, 2022Publication date: February 1, 2024Inventor: Kamraan Gill
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Publication number: 20240038339Abstract: A method and system for analyzing sex-chromosome aneuploidies of an individual are provided. In one embodiment, a method comprises training a neural network model based on predetermined information related to at least one sex chromosome. The method also comprises determining a respective sex-chromosome status based on a normalized read depth for a gene in a genome of the individual using a machine learning algorithm. The machine learning algorithm is configured to receive, as inputs, the normalized read depth, and output the respective sex-chromosome status of the individual. In another embodiment, a system I is provided including a neural network model trained based on predetermined information related to at least one sex chromosome and is adapted to determine a respective sex-chromosome status based on a normalized read depth for a gene in a genome of the individual using a machine learning algorithm.Type: ApplicationFiled: August 5, 2021Publication date: February 1, 2024Applicant: Myriad Women's Health, Inc.Inventors: Albert Lee, Kevin Haas, Kevin D'Auria
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Publication number: 20240038340Abstract: An operation of designing or selecting chemical structure information on a lipid molecule forming a particle encapsulating an active ingredient is supported. An inference device includes an acquiring unit configured to acquire input data including at least chemical structure information on a lipid molecule, and a learned model generated by performing a learning process on a learning model that associates input data including at least chemical structure information on a lipid molecule with a transfection efficiency of an active ingredient encapsulated in a particle containing the lipid molecule into a cell and/or a cell survival rate. The learned model infers a transfection efficiency and/or a cell survival rate associated with the input data newly acquired by the acquiring unit.Type: ApplicationFiled: August 30, 2021Publication date: February 1, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomohiro Maeda, Nozomi Ogawa
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Publication number: 20240038341Abstract: The invention discloses a method, a system and a storage medium for consistency analysis of a lithium battery module. The method includes acquiring various microscopic electrochemical parameters corresponding to each single cell in the lithium battery module; respectively establishing a time sequence database of the microscopic electrochemical parameters corresponding to each single cell, based on each of the microscopic electrochemical parameters; and performing consistency analysis on each single cell that meets a preset circuit connection relation based on each time sequence database.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Inventors: Danfei Gu, Mingchen Jiang, Siyuan Chen, Xiao Yan, Enhai Zhao, Qian Li
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Publication number: 20240038342Abstract: New systems, devices, methods and other techniques for eliciting, standardizing and recording patient-reported data in clinical healthcare settings are provided. A new form of specialized computer hardware and software control system is provided, applying new machine learning techniques for translating patients' freeform verbalizations and other patient-reported data to standardized significance codes. In some embodiments, the system also translates such significance codes into standardized medical terminology that is more easily actionable by healthcare providers, as part of a new form of personal health record generated by patients (“PHRP”). In some embodiments, health-related data is normalized based on techniques known as translation vectors. Such translation vectors generate standardized significance codes based on common usage of terms by user(s) of the control system (e.g.Type: ApplicationFiled: July 31, 2023Publication date: February 1, 2024Inventors: Mette Dyhrberg, Christopher V. Beckman, Gillian Sandler
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Publication number: 20240038343Abstract: Methods and systems are disclosed that involve monitoring use by a user of a device, of an application associated with the device, or a combination thereof. The device is configured to provide therapy to the user. The application is configured to provide control of the device, to provide information to the user related to the therapy, or a combination thereof. The methods and systems also involve determining whether one or more milestones associated with an incentive scheme for the user have been satisfied by the use. The incentive scheme relates to continued provisioning of the therapy to the user by the device. The methods and systems also involve unlocking functionality of the device, the application associated with the device, or a combination thereof for the user based on satisfaction of at least one of the one or more milestones.Type: ApplicationFiled: July 18, 2023Publication date: February 1, 2024Inventors: Stewart Joseph Wagner, Sakeena De Souza, Andrew William Gillett
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Publication number: 20240038344Abstract: Provided are a computer program product, system, and method for an orchestrator engine to provide context driven workflow of radiology images and patient data to artificial intelligence engines for further processing. An orchestrator engine, providing context driven workflow, processes the patient information to determine an artificial intelligence program of a plurality of artificial intelligence programs to process the medical image. The artificial intelligence program processes the medical image and the patient data to provide a structured result as output. The structured result with the patient information is forwarded to the radiologist to evaluate the medical image.Type: ApplicationFiled: July 31, 2023Publication date: February 1, 2024Inventors: Nina KOTTLER, Thomas N. Tobias
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Publication number: 20240038345Abstract: This invention describes how users can capture digital artifacts from any medical device using their mobile device. Some examples of medical devices included, but are not limited to a medical ID card, Medical ID bracelet, Electronic Medical Records, blood pressure machines, blood glucose, scales, inhalers, INR, prescription bottles and trays, pulse oximeter, etc.Type: ApplicationFiled: September 25, 2023Publication date: February 1, 2024Inventor: Michelle Fisher
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Publication number: 20240038346Abstract: A text data generation device 100 includes an acquisition unit 121 that acquires object person information representing time-series physical condition of an object person, an estimation unit 122 that estimates time-series states of the object person on the basis of the object person information, and a generation unit 123 that generates text data representing the state of the object person in a given time period, on the basis of the estimated time-series states of the object person.Type: ApplicationFiled: October 11, 2023Publication date: February 1, 2024Applicant: NEC CorporationInventors: Yuji OHNO, Masahiro KUBO
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Publication number: 20240038347Abstract: A text data generation device 100 includes an acquisition unit 121 that acquires object person information representing time-series physical condition of an object person, an estimation unit 122 that estimates time-series states of the object person on the basis of the object person information, and a generation unit 123 that generates text data representing the state of the object person in a given time period, on the basis of the estimated time-series states of the object person.Type: ApplicationFiled: October 11, 2023Publication date: February 1, 2024Applicant: NEC CorporationInventors: Yuji OHNO, Masahiro KUBO