Patents Issued in February 1, 2024
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Publication number: 20240033698Abstract: A mixing system for use in a process bottle for mixing its contents, the mixing system including a low volume magnetically-driven mixer mounted at the bottom of the bottle. The mixer may have vanes and lower grooves, or no vanes and grooves on both upper and lower faces. The mixer has a “microsized” three-dimensional solid inanimate body to enable insertion through relatively small mouth openings at the top of conventional reactor bottles. Methods of assembly are also disclosed which involve passing the microsized mixer through an open mouth of a process bottle and coupling the mixer with a bearing assembly at the floor of the bottle. The bearing assembly includes fixtures sealed around a hole in the floor of the bottle.Type: ApplicationFiled: October 9, 2023Publication date: February 1, 2024Inventors: Chris Ballew, Richard Shor, Matthew Markey, Joshua Rosen
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Publication number: 20240033699Abstract: An apparatus for handling a food product powder includes a sealable container having an interior surface defining a volume in which the food product powder is handled, and a powder outlet. The apparatus includes a jet nozzle that is attached to the container and configured to feed air into the container and direct the air towards the interior surface to remove product powder from the interior surface, such that the air and the removed product powder may flow out of the container via the powder outlet. The jet nozzle includes a ceiling spray opening formed on a first side of the jet nozzle and directed towards a ceiling of the interior surface, and a side wall spray opening formed on a second side of the jet nozzle opposite the first side and directed towards a side wall of the interior surface.Type: ApplicationFiled: December 20, 2021Publication date: February 1, 2024Applicant: Tetra Laval Holdings & Finance S.A.Inventors: Antoine BARON, Blandine MALECOT
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Publication number: 20240033700Abstract: In a centrifugal mixer, a maximum wetting height within a mixing cup is optically detected and is regulated by means of a control of drives.Type: ApplicationFiled: April 25, 2023Publication date: February 1, 2024Inventor: Martin Reuter
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Publication number: 20240033701Abstract: A feedback system that identifies characteristics of a colloid and utilizes the characteristics to initiate and adjust a field applied to the colloid is provided. In one embodiment, the system leverages machine learning to automatically identify a condition of the colloid and adjust the supercooling parameters. Sensors are utilized during supercooling to monitor a condition of the colloid being supercooled. Specifically, characteristics of the colloid are measured at different points, areas, or volumes on the colloid and the measurements are used to determine whether supercooling is being achieved or whether the colloid is starting to freeze or undergoing another undesirable phase change. Based on the measurements, parameters of the field can be adjusted to ensure supercooling of the colloid without freezing or causing another undesirable phase change. When phase change is desired, rate of phase change can be controlled to achieve desired characteristics of the colloid.Type: ApplicationFiled: July 28, 2022Publication date: February 1, 2024Inventors: Krishnan Thyagarajan, Christopher Somogyi
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Publication number: 20240033702Abstract: Use of biodegradable microcapsules comprising a wall made of poly(beta-amino)ester, abbreviated to PBAE, which contains an active substance. These microcapsules may be obtained by a method of interfacial polymerization between an amine monomer and a multi-acrylate monomer. Depending on the intended use, microcapsules with a wall that is weak, breakable or unbreakable and porous or non-porous are used; these properties may be obtained by the choice of the monomers and the thickness of the wall. For certain uses, it is possible to use the polymerization reaction mixture directly, without washing.Type: ApplicationFiled: November 17, 2021Publication date: February 1, 2024Applicant: GEM INNOVInventors: Yohann GUILLANEUF, Catherine LEFAY, Didier GIGMES, The Hien HO, Kaouthar OUDOUA, Thierry RIBEIRO, Yves ORTAIS, Marie-Pierre CESBRON
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Publication number: 20240033703Abstract: The present invention relates to a process for the preparation of biodegradable microcapsules, in particular biodegradable protein- and/or polysaccharide-based microcapsules, as well as dispersions of such microcapsules (microcapsule slurry) that enclose at least one hydrophobic active ingredient. In addition, the present invention relates to biodegradable microcapsules obtainable by the process according to the invention. In another aspect, the present invention relates to the use of the microcapsules and dispersions as an ingredient in consumer products.Type: ApplicationFiled: August 6, 2020Publication date: February 1, 2024Inventors: Britta Raabe, Benjamin Rost, Christina Koepke, Julian Alexander Georgi, Ralf Bertram, Daniela Gregor, Andreas Vogel
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Publication number: 20240033704Abstract: Vortex arc reactor apparatus and method provide a nozzle with converging, throat, and diverging portions. Input structure inputs a reactant and an oxidant into the converging portion. Ignition structure ignites the input reactant and oxidant. A vortex-creating structure creates a vortex of the ignited reactant and oxidant in the converging portion. The input structure, the vortex-creating structure, and the nozzle converging and throat portions are configured to provide a throat-portion-vortex of ignited reactant and oxidant that has an angular velocity which provides (i) negatively-charged particles in an exterior portion of the throat-portion-vortex, (ii) positively-charged particles in an interior portion of the throat-portion-vortex, and (iii) at least one arcing reaction between the positively-charged particles and the negatively-charged particles, to form syngas and at least one aromatic liquid in the nozzle diverging portion.Type: ApplicationFiled: October 12, 2023Publication date: February 1, 2024Inventor: MICHAEL W. ROGERS
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Publication number: 20240033705Abstract: A flow reactor or flow reactor component includes a base plate, a first fluid module having first and second major surfaces, an internal process fluid passage, and a heat exchange channel in the first major surface, the first major surface stacked on the base plate; a second fluid module having first and second major surfaces, an internal process fluid passage and a heat exchange channel in the first major surface, the first major surface stacked on the second major surface of the first fluid module, optional additional fluid modules of the same configuration as the first and second fluid modules stacked successively on the second fluid module, and a top plate having a heat exchange channel in a bottom major surface thereof with the bottom major surface stacked on an uppermost fluid module of (1) the second fluid module and (2) the optional additional fluid modules.Type: ApplicationFiled: August 27, 2021Publication date: February 1, 2024Inventors: Alexander Lee Cuno, Howen Lim, Michael Joseph McLaughlin, III, Kenneth Doyle Shaughnessy, James Scott Sutherland
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Publication number: 20240033706Abstract: The present application provides a continuous preparation system and method for vinylidene chloride. In the present application, by coupling two stages of high gravity reactors, the product vinylidene chloride and water vapor are distilled from a reaction system in form of an azeotrope by adopting a water vapor steam stripping method, and the product obtained using the method has high purity. In addition, by combining steam stripping and high gravity, trichloroethane and alkali solution are rapidly mixed for mass transfer, and the product vinylidene chloride is rapidly distilled from the reaction system in form of the azeotrope (based on rapid diffusion of water vapor), such that the reaction proceeds continuously towards the direction of producing vinylidene chloride, thus significantly improving the conversion rate.Type: ApplicationFiled: December 24, 2021Publication date: February 1, 2024Inventors: Liangliang ZHANG, Liyang ZHOU, Guangwen CHU, Jinyuan LIN, Jihong TONG, Jianfeng CHEN, Yidong ZHANG, Zhigang WU, Yunfei YU
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Publication number: 20240033707Abstract: The present disclosure relates to a solid amine adsorbent of CO2 and a method for preparing the same. The method includes: providing pseudo boehmite; pore-enlarging the pseudo boehmite; calcining the pore-enlarged pseudo boehmite to obtain an aluminum oxide powder; and impregnating the aluminum oxide powder in an organic amine solution, and drying to obtain the solid amine adsorbent of CO2.Type: ApplicationFiled: June 9, 2021Publication date: February 1, 2024Inventors: Zuotai ZHANG, Xuehua SHEN, Feng YAN, Chunyan LI, Fan QU
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Publication number: 20240033708Abstract: This disclosure relates to nanoporous pure silica zeolite (PSZ) adsorbents and uses thereof.Type: ApplicationFiled: December 17, 2021Publication date: February 1, 2024Inventors: Arturo HERNANDEZ-MALDONADO, Zhongfang Chen, Rodinson ARRIETA-PEREZ, Daniela RIVERA-MIRABAL, Gabriela DEL VALLE-PEREZ, Yinghe ZHAO, Shiru LIN, Dariana VEGA-SANTANDER
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Publication number: 20240033709Abstract: In one aspect, an oxygenated hierarchically porous carbon (an “O-HPC”) is provided, the O-HPC comprising: a hierarchically porous carbon (an “UPC”), the HPC comprising a surface, the surface comprising: (A) first order pores having an average diameter of between about 1 ?m and about 10 ?m; and (B) walls separating the first order pores, the walls comprising: (1) second order pores having a peak diameter between about 7 nm and about 130 nm; and (2) third order pores having an average diameter of less than about 4 nm, wherein at least a portion of the HPC surface has been subjected to O2 plasma to oxygenate and induce a negative charge to the surface. In one aspect, the O-HPC further comprises metal nanoparticles dispersed within the first, second, and third order pores. Methods for making and using the metal nanoparticle-impregnated O-HPCs are also provided.Type: ApplicationFiled: August 14, 2023Publication date: February 1, 2024Applicants: AIMM, LLC, The University of DaytonInventors: Luis Estevez, Kenya Crosson
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Publication number: 20240033710Abstract: A method of manufacturing an erosion, sediment and pollution control product comprises heat treating a rice hull filler material for sterilizing the rice hull filler material and increasing the pollutant affinity of the rice hull filler material; filling a tubular containment member with the rice hull filler material in a manner allowing fluid to flow through the containment member and the rice hull filler material. The containment member is a geotextile which may include cellulose based threads treated to be hydrophobic.Type: ApplicationFiled: September 4, 2023Publication date: February 1, 2024Inventor: Michael A. Zock
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Publication number: 20240033711Abstract: The present invention relates to a chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix for adsorptive material separation in liquid media, and a method of producing the chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix.Type: ApplicationFiled: December 21, 2021Publication date: February 1, 2024Inventors: Adrian Ley, Rebecca Petersen, Florian Taft, Patrick Adametz, Axel Thiefes, Kathrin Toeppner, Stella Weber, Nils Gehrmann, Franziska Hagemann, Volkmar Thom
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Publication number: 20240033712Abstract: A composition for capture of acid gas comprising solid porous particles of hypercrosslinked polymer comprising a network of aryl groups linked by methylene (—CH2—) bridging groups formed by Friedel-Crafts catalyzed polymerization or Friedel-Crafts catalyzed post-polymerization cross-linking; wherein the solid porous particles of hypercrosslinked polymer contain absorbed liquid comprising an acid gas absorbent selected from chemical absorbent for acid gas, physical absorbent for acid gas or mixture thereof and the weight ratio of absorbed liquid to solid porous particles of hypercrosslinked polymer is from 1:1 to 5:1.Type: ApplicationFiled: December 22, 2021Publication date: February 1, 2024Inventors: COLIN DAVID WOOD, MATTHEW B MYERS, CAMERON WHITE
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Publication number: 20240033713Abstract: The invention relates to a stationary phase medium for adsorption chromatography, which is in form of porous microspheres suitable for being packed into a chromatographic column. The porous microspheres are made of cross-linked polymeric material and formed with interconnected macropores to constitute a porous network. The invented porous microspheres have a characteristic size ratio of porous network diameter to microsphere particle size, and the porous network is in fluid communication with the ambient via multiple openings, so that molecules are convectively transported through the porous network. Accordingly, the invention shows low back pressure and high binding capacity to molecules at high mobile phase velocities.Type: ApplicationFiled: July 25, 2023Publication date: February 1, 2024Inventors: Hui CHEN, Min-Shyan SHEU, Tsung-Han TU, Jih-Hsien LEE, Bruce C.S. CHOU
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Publication number: 20240033714Abstract: Disclosed are methods of making a porous particle material for use as stationary media and related chromatographic separation devices utilizing the disclosed stationary media.Type: ApplicationFiled: July 27, 2023Publication date: February 1, 2024Inventors: Michael Chitty, Arthur Roy Dixon, JR., James Song, Zhengfei Sun, Zijie Wang, Yinfeng Zong
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Publication number: 20240033715Abstract: A silica-alumina material, its preparation and application thereof are provided. The silica-alumina material has a SiO2/Al2O3 molar ratio of 0.8-1.5, and has a lamellar structure with an average length of 0.5-2 ?m and an average thickness of 30-80 nm, and its calcined form has a specific XRD pattern. The silica-alumina material has the characteristics of large pore volume, two-stage gradient pore channels of mesopores and macropores, as well as high B acid content as in molecular sieve, and shows crystal characteristics of a molecular sieve, and low impurity content, and thus is suitable for use as a carrier for catalytic materials, particularly a carrier for heavy oil hydrogenation catalysts.Type: ApplicationFiled: January 11, 2022Publication date: February 1, 2024Inventors: Huihong ZHU, Tiebin LIU, Hao JIN, Yiming SHI, Zhenhui LV, Guang YANG, Lu LIU, Tao YANG
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Publication number: 20240033716Abstract: An iron-containing catalyst for ammonia synthesis, characterized in that it contains the promoters potassium, calcium and aluminum, wherein the proportion of potassium, calculated as K2O, is 0.08% to 0.6% by weight, the proportion of calcium, calculated as CaO, is 0.8% to 2.2% by weight and the proportion of aluminum, calculated as Al2O3, is 1.0% to 2.3% by weight, is described. The invention further relates to the production of the catalyst according to the invention and to a process for ammonia synthesis using the catalyst according to the invention.Type: ApplicationFiled: August 26, 2021Publication date: February 1, 2024Inventors: Rene ECKERT, Benjamin-Louis KNIEP
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Publication number: 20240033717Abstract: The present disclosure relates to a process for preparing a catalyst for the selective catalytic reduction of nitrogen oxide. The process includes providing a zeolitic material including SiO2 and X2O3 in its framework structure, wherein X is a trivalent element; subjecting the zeolitic material to an ion exchange procedure with one or more iron (II) and/or iron (III) containing compounds; preparing a slurry including the Fe ion-exchanged zeolitic material, one or more copper (II) containing compounds, and a solvent system; providing a substrate and coating the slurry onto the substrate; and calcining the coated substrate. Furthermore, the present disclosure relates to a catalyst for the selective catalytic reduction of nitrogen oxide, an exhaust gas treatment system for the treatment of exhaust gas exiting from an internal combustion engine, and a method for the selective catalytic reduction of nitrogen oxides.Type: ApplicationFiled: December 8, 2021Publication date: February 1, 2024Inventors: Jeff H. Yang, Wen-Mei Xue, Stanley A. Roth
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Publication number: 20240033718Abstract: The present invention relates to a method for preparing a catalyst for selective hydrogenation of cyclododecatriene and a catalyst prepared by the preparation method. The method for preparing a catalyst for selective hydrogenation of cyclododecatriene of the present invention includes: (S1) preparing a ruthenium complex by reacting ruthenium chloride with formaldehyde; and (S2) adding triphenylphosphine to the ruthenium complex and then allowing a reaction to proceed.Type: ApplicationFiled: December 14, 2021Publication date: February 1, 2024Inventors: Youngjin KIM, Namjin JANG
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Publication number: 20240033719Abstract: A catalytic wall-flow filter with improved ammonia emission control, and its use in an exhaust system for gasoline engines, are disclosed. The catalytic wall-flow filter comprises a wall-flow filter substrate; a first catalyst coated on the first plurality of channels, wherein the first catalyst comprises a zeolite; and a second catalyst coated on the second plurality of channels. The second catalyst comprises a platinum group metal (PGM) component, an oxygen storage capacity (OSC) material, and an inorganic oxide support.Type: ApplicationFiled: July 19, 2023Publication date: February 1, 2024Inventors: Ketan CHAVDA, Fezile LAKADAMYALI
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Publication number: 20240033720Abstract: A method of forming a chemically reactive membrane includes applying a first solution to a structure, the first solution includes a macrocyclic ligand having electron-donating ligands and a side functional group for crosslinking, crosslinking a plurality of the macrocyclic ligand to form a first network of crosslinked macrocyclic ligands, and applying a second solution to the structure, the second solution comprising a catalytic center. Each catalytic center complexes with the electron-donating ligands of each macrocyclic ligand to form catalytic sites in the first network of crosslinked macrocyclic ligands.Type: ApplicationFiled: August 23, 2023Publication date: February 1, 2024Inventors: Francesco Fornasiero, Edmond Y. Lau, Carlos A. Valdez
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Publication number: 20240033721Abstract: The present invention relates to a method for recovering and reusing a selective homogeneous hydrogenation catalyst. The present invention relates to a method for recovering a selective homogeneous hydrogenation catalyst from a second reaction resolution in which a synthesis of cyclododecene is completed after synthesizing the cyclododecene by selective hydrogenation of a first reaction solution containing cyclododecatriene, triphenylphosphine, formaldehyde, and ruthenium chloride, and the method includes: preparing the selective homogeneous hydrogenation catalyst from the triphenylphosphine, the formaldehyde, and the ruthenium chloride during the selective hydrogenation of the first reaction solution, and synthesizing the cyclododecene; mixing a solvent containing cyclododecanone with the first reaction solution; and recovering the selective homogeneous hydrogenation catalyst through evaporation separation from the second reaction solution in which the synthesis of the cyclododecene is completed.Type: ApplicationFiled: December 10, 2021Publication date: February 1, 2024Inventors: Youngjin KIM, Jinho PARK, Namjin JANG
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Publication number: 20240033722Abstract: An industrial furnace and a method for roasting or regenerating spent petroleum catalysts. The furnace particularly includes a device to set the catalysts in motion along the bottom of the furnace to cause the catalysts to circulate from the inlet towards the outlet of the furnace; a first zone decarbonizing the spent catalysts to obtain decarbonized catalysts, followed by: a second zone including a plurality of oxygen feed devices distributed along the length of the second zone and placing the decarbonized catalysts in contact with the oxygen feed, the second zone desulfurizing the decarbonized catalysts to obtain roasted or regenerated catalysts.Type: ApplicationFiled: December 16, 2021Publication date: February 1, 2024Inventor: Jean-Pierre DUFOUR
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Publication number: 20240033723Abstract: According to one or more embodiments, particulate solids may be regenerated in a particulate solid treatment vessel. The particulate solid treatment vessel may be connected to a riser. The riser may extend through a riser port of an outer shell of a particulate solid separation section such that the riser may comprise an interior riser segment and an exterior riser segment. The particulate solid separation section may include a gas outlet port, a riser port, and a particulate solid collection area. The riser port may be positioned on a sidewall of the outer shell such that it is not located on a central vertical axis of the particulate solid separation section. The particulate solids may be separated from gasses in the particulate solid separation section.Type: ApplicationFiled: December 14, 2021Publication date: February 1, 2024Applicant: Dow Global Technologies LLCInventors: Matthew T. Pretz, Donald F. Shaw, Richard Edwards Walter, Fermin Alejandro Sandoval
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Publication number: 20240033724Abstract: The present application discloses drop preparation device and drop preparation method and relates to the technical field of biochip. In the drop preparation device, the chip, the temperature control module and the pressure detection unit are provided in the cavity, the temperature control module is configured for adjusting a temperature value in the chip, and the pressure detection unit is configured for detecting a pressure data in the cavity; two chip ports, that is, a sample inlet and an oil inlet are provided at the top of the chip; the perforated cap has a vent hole and is elastically deformed to change a volume of the vent hole. When the perforated cap is directly connected to the oil inlet, the pressing assembly is lifted or lowered to open or cover the vent hole. When the pressing assembly covers the oil inlet, a pressure difference is formed in the chip.Type: ApplicationFiled: May 15, 2023Publication date: February 1, 2024Inventors: Jiang XIA, Zhuhai WANG
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Publication number: 20240033725Abstract: A method for automatically maintaining a pipette tip depth in a conductive fluid during a fluid transfer operation, comprising the steps of: providing a pipetting device, comprising: a pipette tip; a first and a second electrode on the outer surface of the pipette tip; a frame supporting an actuator that is operatively connected to the pipette tip; and a controller that is in electrical connection with the first and second electrodes; providing a container fixed in height relative to the frame, the container holding a conductive fluid having a first liquid level; positioning the pipette tip in the container such that at least a portion of the first and second electrodes are submerged in the conductive fluid; measuring by the first and second electrodes a change in resistance relative to the conductive fluid; sending by the first and second electrodes a signal to the controller relative to the change.Type: ApplicationFiled: October 12, 2023Publication date: February 1, 2024Applicant: Formulatrix International Holding Ltd.Inventors: David WIKHOLM, Rasmus LINDBLOM
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Publication number: 20240033726Abstract: A wafer for carrying a biological sample, the wafer comprising: a pair of circular discs, wherein at least one of the discs is transparent; and a gap between the discs adapted to receive a biological sample. The compact circular shape of the wafer makes it particularly suited for use in a portable device in which the wafer is rotated to enable a camera to image different areas of the sample between the discs. The gap may be sized to pull a biological sample into the gap by capillary action.Type: ApplicationFiled: December 20, 2021Publication date: February 1, 2024Inventors: Hector Zenil, Jürgen Hermann Richard Riedel, Isaac Gerald Frederick Jones
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Publication number: 20240033727Abstract: Provided include a microfluidic device capable of performing reagent exchange, a gas-flow control device, a cell reaction module, and a device for preparing cell samples, such as a single-cell sample, and method of use thereof.Type: ApplicationFiled: December 2, 2021Publication date: February 1, 2024Inventors: Yunyan QIU, Dongdong CHU, Huanlin CHEN, Jian MIAO
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Publication number: 20240033728Abstract: A microfluidic processing system can include a reagent delivery network including an inlet microfluidic channel fluidly coupled to an outlet microfluidic channel via a microfluidic cross-channel. The microfluidic cross-channel can include a constriction region and a reagent storage chamber. The microfluidic processing system can also include a resistor positioned along the inlet microfluidic channel at a location to redirect fluid through the constriction region and into a reagent storage chamber, and process microfluidics fluidly coupled downstream from the outlet microfluidic channel.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Applicant: Hewlett-Packard Development Company, L. P.Inventors: Viktor Shkolnikov, Alexander Govyadinov
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Publication number: 20240033729Abstract: A reagent delivery network can include an inlet microfluidic channel, a microfluidic cross-channel branching off from the inlet microfluidic channel, a resistor positioned along the inlet microfluidic channel at a location to redirect fluid from the inlet microfluidic channel into the microfluidic cross-channel, and an outlet microfluidic channel having a side-wall opening connected to the microfluidic cross-channel. The outlet microfluidic channel can receive fluid from the microfluidic cross-channel. The microfluidic cross-channel can include a constriction region and a reagent storage chamber having reagent therein.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Applicant: Hewlett-Packard Development Company, L.P.Inventors: Alexander Govyadinov, Viktor Shkolnikov
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Publication number: 20240033730Abstract: A system for testing a microfluidic sample chip to perform PCR and/or fluorescence type testing of the biological samples. The chip having the form of a hollow block including at least one chamber delimited by an upper wall and a lower wall. The chamber receiving a sample to be tested and the chamber being associated with thermalization element and with a sensor to measure the fluorescence. The system further includes a tab, preferably opaque and/or rigid or semirigid, positioned in the continuation of, and preferably in the same plane as, the walls.Type: ApplicationFiled: November 29, 2021Publication date: February 1, 2024Inventors: Maël LE BERRE, Claire LEBOUTEILLER, Bilal HADJI
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Publication number: 20240033731Abstract: A test apparatus includes a holder that is capable of holding a test container in which a test object is to be provided, an optical measurement section that performs predetermined processing on the test object of the test container held by the holder, and a hardware processor that controls holding of the test container by the holder and releasing of the holding. In this test apparatus, the test container released from the holding moves in a gravity direction.Type: ApplicationFiled: June 15, 2023Publication date: February 1, 2024Inventors: Kengo FUSHIYA, Dai SUWAMA
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Publication number: 20240033732Abstract: A microfluidic chip includes an integrated chip support (1), a continuous phase liquid inlet (1-6), an intermediate phase liquid inlet (1-7), a dispersed phase liquid inlet (2), an injection capillary tube (3), a collection capillary tube (4), a collection port (5), capillary tube nesting assemblies (6) and capillary tube coaxial fine adjustment assemblies (7). The chip support (1) is provided with threaded holes (1-1), sealing holes (1-2), capillary tube coaxial alignment holes (1-3), adjusting holes (1-4) and positioning holes (1-5). The injection capillary tube (3) and the collection capillary tube (4) present a three-dimensional coaxial alignment under the combined adjustment of the adjusting holes (1-4) and the capillary tube coaxial fine adjustment assemblies (7), and the capillary tube nesting assemblies (6) can realize the fixing and sealing of the capillary tubes in the chip support (1).Type: ApplicationFiled: November 3, 2021Publication date: February 1, 2024Inventors: Kunyun HE, Benxiang ZHANG, Yongzheng ZHENG
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Publication number: 20240033733Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess.Type: ApplicationFiled: June 21, 2023Publication date: February 1, 2024Inventors: Donald J. Thomas, Hong Cai, Robert B Cary
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Publication number: 20240033734Abstract: Methods include treating a portion of a sample composition to be tested for presence of an analyte by depleting or blocking the target analyte. The treated composition may be used to equilibrate an acoustic wave sensor prior to exposing the sensor to the untreated sample composition for analysis. By using the treated sample composition, in which the analyte is depleted or blocked, to equilibrate the sensor, the sensor may be equilibrated with a composition having a similar viscosity and non-specific binding characteristics to the untreated sample composition, which should result in improved accuracy when analyzing the analyte in the untreated sample composition.Type: ApplicationFiled: October 10, 2023Publication date: February 1, 2024Inventor: Ian Harmon
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Publication number: 20240033735Abstract: The present invention relates to a method of diagnosing cardiovascular disease (CVD). The method comprises obtaining a whole blood sample from a subject; separating components of the whole blood sample into a plurality of fluid fractions; collecting one or more selected fluid fractions comprising one or more separated components of the whole blood sample, wherein the one or more separated components comprise cardiac cells such as cardiomyocytes; and detecting expression of one or more cardiovascular disease-associated biomarkers from the cardiomyocytes from the selected fluid fractions thereby determining one or more related cardiovascular diseases in the subject.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Inventors: Bee Luan Khoo, Mingze Zhu
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Publication number: 20240033736Abstract: A device containing a retaining mechanism comprising: a resiliently biased latch member adapted for motion between at least three positions; a fusible retaining member having at least one engagement surface configured to engage with and act as a stop to the motion of the latch member between two of said positions; and a heating member positioned adjacent to the retaining member; wherein one motion of the latch member between said positions causes it to engage with the fusible retaining member and stop said motion, and activation of the heating member affects at least a portion of the fusible retaining member causing it to soften, melt, weaken or break allowing the latch member to move so as to release the latch member for a further motion between said positionsType: ApplicationFiled: August 26, 2021Publication date: February 1, 2024Inventor: Ralph LAMBLE
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Publication number: 20240033737Abstract: The disclosure provides devices, methods and systems for continuous dielectrophoresis cell sorting to isolate different populations of cells, and applications thereof.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Inventors: Lisa A. Flanagan, Alan Y. L. Jiang, Jaclyn Nicole Hanamoto, Clarissa C. Ro
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Publication number: 20240033738Abstract: The presently described techniques relate generally to providing motion feedback (e.g., motion system calibration and/or sample alignment) in the context of an imaging system (such as a time delay and integration (TDI) based imaging system). The architecture and techniques discussed may achieve nanoscale control and calibration of a movement feedback system without a high-resolution encoder subsystem or, in the alternative embodiments, with a lower resolution (and correspondingly less expensive) encoder subsystem than might otherwise be employed. By way of example, certain embodiments described herein relate to ascertaining or calibrating linear motion of a sample holder surface using nanoscale features (e.g., sample sites or nanowells or lithographically patterned features) provided on a surface of the sample holder.Type: ApplicationFiled: July 21, 2023Publication date: February 1, 2024Inventors: Michael Burek, Gregory Holst, Danilo Condello, Dustin Blair
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Publication number: 20240033739Abstract: A fluidic device includes a plurality of reaction wells, typically in a dense array, with at least one bead retention segment in fluid communication with and spatially separated from at least one signal detection segment. A respective bead retention segment can be configured to hold a single bead, which can have a reagent attached thereto.Type: ApplicationFiled: October 5, 2023Publication date: February 1, 2024Inventors: John Michael Ramsey, William Hampton Henley
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Publication number: 20240033740Abstract: A digital microfluidic device includes an array of controllable electrode pads alignable with a fluid passageway and a control portion. The control portion is to cause electrowetting movement of a droplet within the fluid passageway through a circuit of multiple different zones of the electrode pads. The electrowetting movement is to iteratively expose the droplet within a current zone of the different zones for a selectable current time period at a current temperature of a list of consecutive temperatures, further expose the droplet within the current zone, for each respective selectable subsequent time period, at each respective subsequent temperature of the list which is greater than the current temperature, and move the droplet into a subsequent zone of the different zones when one of the respective subsequent temperatures is less than the current temperature.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.Inventors: Evan Kirshenbaum, Viktor Shkolnikov
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Publication number: 20240033741Abstract: The present invention provides a thermal cycler capable of rapidly and efficiently heating and cooling a reaction liquid. The thermal cycler according to the present invention comprises: a temperature control block where a reaction vessel can be installed, a thermoelectric conversion unit capable of heating and cooling, a temperature sensor that measures the temperature of the temperature control block, an insulating substrate that is in contact at one surface with the thermoelectric conversion unit, and a heat radiating unit that is provided on the other surface of the insulating substrate and serves for discharging the heat of the thermoelectric conversion unit to the outside, wherein the temperature control block is heated and cooled by controlling a current or voltage supplied to the thermoelectric conversion unit on the basis of the temperature of the temperature adjustment block measured by the temperature sensor.Type: ApplicationFiled: December 18, 2020Publication date: February 1, 2024Applicant: Hitachi High-Tech CorporationInventors: Nobuyuki ISOSHIMA, Tatsuya KOBARI, Masashi SHIBAHARA, Toshiki YAMAGATA, Yoko MAKINO, Wataru SATOH
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Publication number: 20240033742Abstract: A container unit for handling containers includes a support surface arranged with a plurality of seats. Each of said sets is adapted to contain a container, and each container is provided with a container data carrier adapted to contain a unique identifier of the container. The container unit comprises at least one container unit data carrier adapted to contain data of the containers contained in the seats, said data comprising the unique identifiers of each container, and the position of each container in the seats. A nest locator is provided on the surface of the container unit. The nest locator is adapted to be the reference for mapping the position of the containers in the seats.Type: ApplicationFiled: January 20, 2022Publication date: February 1, 2024Inventor: Tod Urquhart
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Publication number: 20240033743Abstract: A sample holder is provided. The sample holder includes a first member including a first retaining mechanism configured to retain a first substrate comprising a sample. The first retaining mechanism configured to retain the first substrate disposed in a first plane. The sample holder further includes a second member including a second retaining mechanism configured to retain a second substrate including a reagent medium disposed in a second plane. The sample holder further includes an alignment mechanism connected to one or both of the first member and the second member. The alignment mechanism configured to align the first and second members along the first plane and/or the second plane such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned and within a threshold distance along an axis orthogonal to the second plane.Type: ApplicationFiled: September 17, 2021Publication date: February 1, 2024Inventors: Augusto Manuel Tentori, Hanyoup Kim, Siyuan Xing, Rajiv Bharadwaj, Bill Kengli Lin, Felice Alessio Bava, Pratomo Putra Alimsijah, Hendricus Marindra, Spontaneous Rose Mcknight Russell, Nabil Mikhaiel
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Publication number: 20240033744Abstract: Various embodiments of the present disclosure disclose a system for forming a sealed chamber for preparing samples therein. In particular, various embodiments present an assembly that includes a sample device and a lid for forming a sealed chamber that can be used for, among other things, incubating samples therein. When the lid engages with the sample device, a plurality of snap joint elements of the lid engage with a respective plurality of snap joint elements to form a seal between the lid and the sample device.Type: ApplicationFiled: June 2, 2023Publication date: February 1, 2024Applicant: 10x Genomics, Inc.Inventors: David Morgan, Denis Pristinski, Evan Dejarnette, Joshua Cataldo, Yiran Zhang, Zhenping Guan, Adrian Tanner, Lila Haba, Brenden Janatpour Brown, Francis Cui
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Publication number: 20240033745Abstract: This biochemical analysis device has a configuration in which a reaction unit is installed on a device body, the reaction unit including: a test tube unit having a plurality of test tubes or a test tube unit in which a plurality of test tubes can be installed; a cassette guide; and a cassette box that allows attachment/detachment of the cassette guide. The cassette guide includes a flange part, a ventilation opening provided in the flange part, and a test tube insertion part provided to the flange part. The test tube insertion part is a closed structure, the flange part is installed on the upper surface section of the cassette box, and the ventilation opening suctions air above the flange part via negative pressure generated by an internal space of the cassette box.Type: ApplicationFiled: August 31, 2020Publication date: February 1, 2024Inventors: Bohao CHENG, Hayato SHIMIZU, Toshiki YAMAGATA, Masashi SHIBAHARA, Yoko MAKINO
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Publication number: 20240033746Abstract: The invention relates to a crusher for mineral materials or recycled materials, in particular rotary impact crushers or jaw crushers, having a crusher unit (10), which has a movable first crusher body (11), in particular a rotor or a crusher jaw, wherein a second crusher body (14), in particular an impact rocker or a crusher jaw, is assigned to the first crusher body (11), wherein a crushing gap (15) is formed between the crusher bodies (11, 14), wherein a movable assembly of an overload triggering device (30) is coupled to the first or to the second crusher body (11, 14), wherein the movable assembly has a cylinder (25) of a hydraulic cylinder (20) or a piston (23) guided in the cylinder (20), wherein the movable assembly is designed to permit a motion of the coupled crusher body (11, 14) increasing the width of the crushing gap (15) in an evasive motion, wherein a pressure chamber (24) is formed in the hydraulic cylinder (20), which pressure chamber is delimited by a piston (23), and wherein the overload trType: ApplicationFiled: July 20, 2023Publication date: February 1, 2024Inventor: Till Krauss
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Publication number: 20240033747Abstract: Disclosed is a bladed grinder (20) for plaster waste, comprising a frame (10) comprising a support for a rotating shaft, comprising a main rotating shaft (30) comprising a plurality of vanes (40) radially attached on the main rotating shaft (30), comprising a system for rotating the main rotating shaft (30), comprising at least one inlet opening (60) for introducing waste comprising plaster, comprising at least one outlet opening for recovering large size waste, comprising, in the lower portion, openings covered with separation grids for filtering the defragmented gypsum, comprising a partially cylindrical cover which covers a continuous surface, characterised in that the cover is divided into at least two removable cover sections (50).Type: ApplicationFiled: December 29, 2021Publication date: February 1, 2024Inventors: Jean-Luc RITLENG, Geoffrey RITLENG, Arnaud RITLENG