Abstract: Disclosed is a device for determining a concentration of cells of a given size in a sample of fluid, the sample comprising a plurality of cells, comprising: a light source arranged to emit light along a central axis to illuminate the plurality of cells in the fluid sample; a detector arranged to receive light at a plurality of displacements from the central axis, the light having passed through the plurality of cells in the fluid sample, and to produce a plurality of signals, each associated with, and indicative of an intensity of the received light at, a respective one of the plurality of displacements; and a processor arranged to determine a concentration of cells of a given size, based on the plurality of signals from the detector, wherein the processor is arranged to compare the plurality of signals from the detector with one or more pre-stored thresholds or profiles, indicative of a particular concentration.

Abstract: Devices, systems, and methods for filter life prediction for an aspirating smoke detector are described herein. In some examples, one or more embodiments include a computing device comprising a memory and a processor to execute instructions stored in the memory to log operational data of the aspirating smoke detector for a first time period to generate an initial data set, fit a machine learning model to the initial data set, and determine, based on the machine learning model, a remaining useful life of the filter.

Abstract: The invention is directed to a method for recording a motion trajectory of an individual particle in a sample and to a light microscope performing this method. Starting from an at least approximately known initial position, the particle is scanned with an intensity distribution of a scanning light comprising a local intensity minimum. When illuminated with the scanning light, the particle to be tracked generates a detectable light signal, from the intensity of which updated coordinates of the particle are calculated. According to the invention, the scanning is terminated when a second measured variable detected in parallel satisfies a termination criterion.

Abstract: A system is described wherein a plurality of lasers are used to irradiate particles in a flow cytometer's flow stream. In certain embodiments, a light source having a plurality of lasers configured for irradiation of a flow stream are disclosed where discrete intervals of irradiation by one or more discretely activated lasers are triggered by irradiation of one or more particles in the flow stream with one or more continuously on lasers.

Abstract: A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; and determine a first blood parameter based on the first set of cell regions.

Abstract: Improved methods for analyzing cells by combining information from the same cell before and after lysis. The methods of the present invention allow examination of the interactions or relationships between cellular physiological parameter that can only be measured in living cells (i.e., metabolic state) and the expression of proteins and peptides of interest. Single cell processing is made possible by determination of wells containing single cells therein and avoiding analysis of well containing no or multiple cells therein. Fluorescent and/or bright-field imaging may be used in certain embodiments.

Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.

Abstract: An optical calibration tool includes a first body, a light emitter, a light receiver, a second body, and a light reflecting member. The first body has a first engaging port and a second engaging port. The light emitter and the light receiver are disposed in the first body. The second body has a third engaging port and a channel communicated with each other. The third engaging port is configured to selectively engage one of the first engaging port and the second engaging port. When the third engaging port is engaged with the first engaging port, the light emitter is optically coupled to the light reflecting member. When the third engaging port is engaged with the second engaging port, the light receiver is optically coupled to the light reflecting member.

Abstract: An object of the present invention is to realize an optical analysis system that enables long-term analysis by reducing the amount of liquid used for analysis. The optical analysis system includes: a first flow channel for transporting a liquid in a container; a branching medium for alternately outputting the liquid and the gas in the first flow channel; a third flow channel for transporting the liquid and the gas flowing out from the branching medium; an analysis cell into which the liquid and the gas in the third flow channel flow; a fourth flow channel that is connected to the analysis cell to discharge the liquid and the gas after passing through the analysis cell; a pump for transporting the liquid and the gas; and a control device. Then, the control device sets a reference liquid amount that is a reference required for analysis, and controls the branching medium and the pump to make the liquid and the gas alternately flow into the third flow channel.

Abstract: A dual resolution spectrometer includes a slit plate comprising a slit receiving light reflected from a measurement target. The slit plate directs the light reflected from the measurement target to a first mirror. The first mirror reflects light from the slit to a diffraction grating. The diffraction grating disperses light from the first mirror according to a wavelength of the light. The diffraction grating directs light in a first wavelength region to a second mirror and directs light in a second wavelength region to a third mirror. The second mirror reflects the light in the first wavelength region to a detector. The third mirror reflects the light in the second wavelength region to the detector. The detector detects the light in the first wavelength region and the light in the second wavelength region with different resolutions from each other.

Abstract: A small-sized gas detection apparatus with high measurement accuracy is provided. The gas detection apparatus includes a light emitting portion (1); a light receiving portion (2); a first mirror (3) that has a quadric reflective surface and reflects light emitted from the light emitting portion; and a second mirror (4) that has a quadric reflective surface and reflects the light reflected by the first mirror to the first mirror. The quadric surfaces of the first mirror and the second mirror have convex portions facing in a same direction. The first mirror reflects the light reflected by the second mirror to the light receiving portion. When one surface of a substrate on which the light emitting portion and the light receiving portion are mounted is used as a reference plane, the first mirror and the second mirror are provided at positions higher than the reference plane and have different heights.

Abstract: The present invention relates to a spectrometer comprising a plurality of arrays of quantum dots, the arrays being arranged such that primary light emitted by a light source is incident thereon and excites the quantum dots such that the quantum dots emit secondary light such that the secondary light can be incident on a sample, the secondary light having a different spectral distribution to the primary light, at least one detector configured to receive the secondary light reflected or transmitted by the sample, and an evaluation device configured to determine spectral information of the secondary light received by the at least one detector. The invention also relates to a method for producing such a spectrometer.

Abstract: A spectroscopy analyzer for the identification of substances contained in a sample using a set of spectroscopy techniques and methods using a single device that can be configured to conduct a variety of tests using multiple optical devices and elements. The results are combined in a consolidated sample diagnostic profile that can then be compared with benchmark information produced from other spectroscopy analysis results downloaded from external databases and interpreted using artificial intelligence.

Abstract: A system and method indicate capability for detecting methane leaks inside buildings. This approach provides the ability to detect methane behind high efficiency coated windows and can extract methane concentration (rather than concentration-path length product CL). Lock-in imaging technologies can facilitate lower laser transmitter power. A field deployable, hand held prototype sensor for use in remote sensing a appropriate standoff distances can support operational testing. Distance infrared imaging of methane is feasible. Fully characterized real time image of a methane cloud offers operational advantages in accuracy and safety as compared to current sensors.

Abstract: A method of producing a model to detect changes in forest cover is disclosed. The method includes obtaining forest-cover classification data of a land area. The land area includes one or more subregions having unchanged forest-cover classifications between a first time and a second time. The method further includes obtaining remotely sensed data of the subregions at multiple times. For at least one forest-cover classification, the method includes applying a statistical analysis to the image data to determine one or more threshold values representing measurement variations. The method further includes comparing subsequently obtained image data to the one or more threshold values and classifying the one or more subregions as changed or unchanged based on the comparison of subsequently obtained image data to the one or more threshold values.

Abstract: A method for identifying carpet materials includes receiving, by a controller coupled to an NIR spectrometer, a predetermined number of NIR measurements of a sample of the carpet material conducted over a bandwidth of a subset of a full NIR spectrum. The NIR spectrometer performs the NIR measurements under control of the controller. Also, sending the NTR measurements to a remote identification server including a spectra library of known carpet materials. The method also includes receiving a matching result from the remote identification server, sending the matching result to a remote appraisal server, and receiving an appraised value of the carpet material.

Abstract: According to an aspect of the present inventive concept there is provided a probe for analysis of a liquid in a mixture of the liquid and solid substance. The probe comprises: a tube comprising a sample end configured to be inserted into the mixture; a cap configured to come into contact with the mixture at the sample end, the cap comprising one or more openings configured for allowing passage of the liquid therethrough, and for preventing passage of the solid substance therethrough; and an optical measurement head arranged in the tube and configured to come into contact with the liquid having passed the one or more openings, wherein the optical measurement head is configured to collect measurement information for analysis of the liquid.

Abstract: An optical sensor includes: a metal base formed into a cylindrical shape; an optical fiber member inserted into the base; and a sensor head that is bonded to the base and is optically connected to the optical fiber member, the sensor head including a head portion formed from monocrystalline alumina, in which the base includes a fitting portion into which the sensor head is inserted, and the sensor head is bonded to the fitting portion via a bonding member.

Abstract: A method for identification of amino acid residues in a fluid sample (9) is disclosed. The method comprises producing (100) a light signal from a laser (1) and illuminating (120) the fluid sample (9) with the light signal through a lens in a sensing probe (8). A light signal is acquired (130) from the fluid sample (9) and a plurality of features is extracted (140) from the light signal. The extracted plurality of features is compared with a model in a database to determine and quantify the amino acid residues in the fluid sample (9).

Abstract: An imaging system for capturing spatial-omic images of biological tissue samples may include an imaging chamber configured to secure a biological tissue sample placed in the imaging system; a Time Delay and Integration (TDI) imager comprising at least one scan line; a light source configured to illuminate an area on the biological tissue sample that is being captured by the TDI imager; and a controller configured to cause the TDI imager to scan the biological tissue sample using one or more TDI scans of the biological tissue sample.

Abstract: Disclosed are: a method for detecting a target biomolecule in a biological sample, in which the method can be rapidly and inexpensively performed on site to diagnose diseases such as infectious diseases; an FO-LSPR optical fiber sensor which can be used therein; and a disposable sensor cartridge having the sensor mounted. The disposal sensor cartridge of the present invention can he used in the rapid detection of a target biomolecule, by mounting an optical fiber sensor and then connecting FO-LSPR equipment thereto. When an FO-LSPR molecular diagnostic system using the optical fiber sensor cartridge of the present invention is combined with a CRISPR-Cas system, target biomolecules can be detected accurately and conveniently without nucleic acid amplification.

Abstract: Methods and systems for matching color and/or appearance of a surface of an object are provided. In one example, method includes determining a gloss of the surface of the object at one or more angles. The gloss is compared to a minimum gloss threshold to determine a condition of the surface of the object. If the gloss is at or exceeds the minimum gloss threshold, the surface is properly conditioned. If the gloss is less than the minimum gloss threshold, the surface is improperly conditioned. The color and/or appearance of the surface of the object is characterized if the surface is properly conditioned.

Abstract: A method and device for identifying the washing quality of a feather material are applied to a feather material washing apparatus and essentially entail: a sampling unit that takes an appropriate amount of the water discharged from the feather material washing apparatus as a water sample, an impurity removing module that removes feather fiber and impurities that may compromise inspection accuracy, and a laser sensing device that senses, while the water sample is static, a transparency value of a portion of the water sample that extends across a predetermined distance, in order to identify the washing quality of a washed feather material. The method and device for identifying the washing quality of a feather material exercise intelligent judgment to enable a consistent standard, to ensure the efficiency and quality of a feather material washing procedure, and to reduce the associated costs.

Abstract: A fluorescence lifetime imaging microscopy system comprises a microscope comprising an excitation source configured to direct an excitation energy to an imaging target, and a detector configured to measure emissions of energy from the imaging target, and a non-transitory computer-readable medium with instructions stored thereon, which perform steps comprising collecting a quantity of measured emissions of energy from the imaging target as measured data, providing a trained neural network configured to calculate fluorescent decay parameters from the quantity of measured emissions of energy, providing the data to the trained neural network, and calculating at least one fluorescence lifetime parameter with the neural network from the measured data, wherein the measured data comprises an input fluorescence decay histogram, and wherein the neural network was trained by a generative adversarial network. A method of training a neural network and a method of acquiring an image are also described.

Abstract: Identification of aromatic interactions, e.g. ?-interactions, of mesophase formation, and methods related thereto, including the use of fluorescent light and optical imaging and/or detection schemes for the identification of ?-interactions of mesophase formation, and methods related thereto. Methods include interacting fluorescent light with a pitch composition; receiving fluorescent light emissions from the pitch composition; and detecting the onset of mesophase formation upon detecting a normalized fluorescence intensity (I/I0) of the fluorescent light emissions in the range of about 0.4 to about 0.7 at a wavelength in the range of about 430 nm to about 470 nm for an exposure of about 1.5 seconds.

Abstract: Disclosed are thallium-sensitive assay methods and compositions for identifying effectors of monovalent ion channels, transporters, or channel-linked receptors. Further described are methods that extend the detection window of an assay to ensure assay compatibility with basic fluorescence plate readers, fluorescence microscopes, high content screening instrumentation, and flow cytometers. The ability to conduct ion mobilization screens on additional instrumentation also enables significantly more complex data acquisition, analysis, and interpretation.

Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.

Abstract: A lab-on-a-chip system (100) comprises an optical detection waveguide (122) that has an at least partially periodic structure (123, 501, 502, 503, 504) that is configured to couple light (152) from surroundings of the optical detection waveguide (122) into the optical detection waveguide (122). The lab-on-a-chip system (100) furthermore also comprises a microfluidic network (212), wherein the microfluidic network (212) has multiple lines and at least one reaction chamber (211, 211-1, 211-2, 211-3).

Abstract: A method and system of analyzing a resected tissue specimen is provided. The method includes: a) using an imaging system to image a tissue sample with excitation light configured to produce fluorescent emissions from the tissue sample, the imaging producing signals representative of the fluorescent emissions from the sample; b) determining a presence or an absence of at least one suspect tissue region on the tissue sample; c) determining a spatial location of said at least one suspect tissue region determined to be present on the tissue sample; d) using the imaging system to image the suspect tissue region at the determined spatial location with excitation light configured to produce Raman scattering from the sample, the imaging producing signals representative of the Raman scattering from sample; and e) analyzing the determined suspect tissue region using the signals representative of the Raman scattering from the sample.

Abstract: The present disclosure provides bio-imaging devices including multiple, modular channels for imaging biological substrates, and methods of using same to obtain mono- or multi-channel images of biological substrates.

Abstract: Disclosed are confocal microscope systems capable of spectral multiplexing. The systems beneficially provide multiple excitation spots on a sample plane simultaneously, and each spot can provide a different wavelength of excitation light. Scanning the excitation spots across a sample can therefore provide multispectral fluorescence imaging at a faster rate than through the sequential process of conventional laser scanning confocal microscopes. A method of generating a distribution from multiplexed spectral fluorescence data is also disclosed.

Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.

Abstract: A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.

Abstract: The present invention relates to a gas species identification method of a photoactive gas sensor using variable light irradiation. An object of the present invention is to provide a gas species identification method of a photoactive gas sensor using variable light irradiation capable of smoothly identifying a gas species without a selectivity difficult problem even with only a single chemical resistance-type gas sensor by irradiating light while periodically changing an amount of light at the time of irradiating the light to the photoactive gas sensor.

Abstract: A gem imaging system includes a stage having a platform configured to hold an object. The system further includes a light source configured to illuminate the object. The system further includes a housing configured to at least partially enclose the object. The housing is configured to position a mobile device such that a camera lens of the mobile device is aligned with the object.

Abstract: An inspection system and a method for analyzing defects in a product, in particular a printed circuit board product, a semiconductor wafer or the like, the inspection system includes a projection device , an optical detection device , and a processing device, the projection device having an illuminating unit and a spectrometer member configured to split white light into its spectral components and project a multichromatic light beam thus formed from monochromatic light beams onto a product at an angle of incidence ?, the optical detection device having a detection unit comprising a camera and an objective , the camera being configured to detect the multichromatic light beam reflected on the product in a detection plane of the detection unit, the detection plane being perpendicular, preferably orthogonal, to a product surface of the product, the illuminating unit having at least two light-emitting diodes disposed in a row and an exit aperture extending along the row.

Abstract: A printing device includes an inspection system that uses variable intervals to inspect printed sheets for a print job. The variable interval sets the inspection points for the inspection process. Once a defect is detected on a printed sheet, the sheets in the paper path are cleared and separated into good and defective sets of sheets. The cleared sheets are sent to an output bin for further review. After addressing the defect, the last good sheet printed is determined and adjusted to resume printing operations.

Abstract: A lighting fixture and a multi-station lighting system are provided. The lighting fixture includes: a body module, an adjustment module, a test module, a carrier module, a connecting wire, and a control device. A display screen is mounted on the carrier module, and the test module corresponding to the display screen is mounted on the adjustment module. A first detection point of the test module is correspondingly connected to a second detection point on the display screen through the adjustment module.

Abstract: A visual inspection apparatus of the present invention includes a rotational portion configured to rotate in a state that an inspection target is placed on the rotational portion, a mirror portion provided so as to reflect the inspection target in the state that the inspection target is placed on the rotational portion, an imaging portion configured to image the inspection target reflected in the mirror portion, an adjustment portion configured to change an imaging angle of the imaging portion relative to the inspection target reflected in the mirror portion, and an inspection portion configured to inspect a surface of the inspection target based on image data captured by the imaging portion.

Abstract: A device for dielectric material characterization of a test sample is provided. The device comprises a resonator block comprising a groove at at least one side of the resonator block, wherein the groove comprises at least a first inclined surface and a second inclined surface and is configured to contact the test sample via the first inclined surface and/or the second inclined surface. In this regard, the resonator block is configured to generate a rotational electric field coupled between the first inclined surface and the second inclined surface of the groove and further to propagate the rotational electric field partially or fully through the test sample in order to perform dielectric material characterization of the test sample.

Abstract: The present disclosure provides a device and method for measuring a correlation between fatigue performance and a microstructure of a one-dimensional (1D) nanomaterial in situ in a transmission electron microscope (TEM), belongs to the technical field of in-situ testing and characterization of microstructures of nanomaterials. The device includes a chip part, a supporting part, and a control circuit. The supporting part is a bracket and a cable disposed on a transmission sample holder, and the circuit part consists of cables connected to the chip and a power supply capable of applying different waveforms, variable voltages, and variable frequencies. This design breaks through a traditional mechanical stress-driven fatigue performance test method, and achieves controllable adjustment of different amplitudes and cycles by using an electric field formed by a voltage and adjusting a voltage size and frequency, such that the 1D nanomaterial vibrates in the electric field to achieve fatigue performance testing.

Abstract: An X-Ray-Spectroscopy (XRS) inspection station is presented for inspecting objects progressing on a production line. The XRS station comprises: at least one XRS inspection system each defining an XRS inspection region and performing one or more XRS inspection sessions on the object passing through the inspection region while progressing on the production line and generating XRS inspection data piece for said object. The XRS inspection system comprises at least one emitter, each producing X-Ray or Gamma-Ray exciting radiation to excite at least a portion of the object, and at least one detection unit that detects a response of said at least portion of the object to the exciting radiation and generates corresponding XRS inspection data pieces comprising data indicative of an XRS signature of marking(s) embedded in plastic material composition of the object, said data indicative of the XRS signature being informative of one or more conditions of plastic material composition in the object.

Abstract: An x-ray fluorescence system and method of fabrication are provided which include a titanium x-ray source, a focusing, doubly-curved lithium fluoride (LiF) crystal optic, and a detector. The titanium x-ray source includes a titanium target on which electrons impinge to generate a diverging x-ray beam with a titanium-based characteristic energy, and the focusing, doubly-curved LiF crystal optic monochromates and focuses the diverging x-ray beam from the titanium x-ray source to provide a monochromated and focused x-ray excitation beam directed to impinge on a sample. The crystal optic and the titanium x-ray source operate at a Bragg angle which facilitates polarization within the x-ray fluorescence system. The detector receives fluorescence from the sample induced by the x-ray excitation beam impinging thereon, with the fluorescence is indicative of a concentration of at least one element in the sample.

Abstract: Methods of XRF quantitative analysis of heavy metal elements based on LLE-SVR, such as may include: establishing a relationship between peak information and element content by using Local Linear Embedding Dimensionality For Reduction and Support Vector Regression Predictive Algorithms based on machine learning, to quantitatively analyze the content information of elements contained in substances.

Abstract: A magnetic resonance device for monitoring growth of tissue in one or more bioreactors. The device can include a first magnet and a second magnet that can form a uniform magnetic field of desired strength around at least one sample of effluent from at least one bioreactor. At the command of a controller, an RF signal can illuminate the at least one magnetized sample, and sensors can detect at least one echo signal from the at least one magnetized sample. The controller can characterize the at least one sample based on the at least one echo signal. A resonator can shape the at least one echo signal.

Abstract: A flash fire instrumented manikin articulation system designed to evaluate the thermal protective performance of protective clothing when exposed to flames. The flash fire instrumented manikin articulation system includes an instrumented manikin and an articulation system designed to simulate exposure to a flash fire and simulate dynamic movement including walking and jogging.

Abstract: To provide a thermal analysis system and a thermal analysis method capable of easily performing thermal analysis while suppressing atmospheric exposure associated with sample movement. A thermal analysis system according to the present disclosure includes a sample preparing unit and a thermal analyzing unit. The sample preparing unit includes a wall portion forming an internal space, a gate portion capable of opening and closing an opening of the wall portion, and a sample holding member including a sample holder and temperature sensors. The thermal analyzer includes a moving mechanism for moving a sample holder into a thermal analysis part, a sealing mechanism for sealing the sample holder from an internal space of a sample preparation part, and a coupling mechanism for connecting a heating tube of the thermal analysis part to a gate part in a state of sealing the heating tube from the outside.

Abstract: A method for diagnosing lithium plating in lithium ion batteries includes performing electrochemical impedance spectroscopy analysis on complete or undisassembled lithium-ion batteries under different temperatures.

Abstract: A chemiresistive sensor has a low limit for detecting NO2 at ambient temperature. An active layer of the sensor includes a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

Abstract: A system for introduction of digital integrity self-sensing of corrosion-protective coatings to remotely detect, locate and monitor coating barrier failure in real time to identify corrosion prone hotspots before corrosion damage of protected substrate materials occurs.