Abstract: The present invention provides a sensing electrode, an electrochemical sensing system using the sensing electrode, methods of preparing and using the sensing electrode and the electrochemical sensing system. The sensing electrode includes a base electrode having a conductive surface, and a coating layer formed on the conductive surface. The coating layer has cavities or holes, each of which can be filled with, bound to, or occupied by, an analyte molecule. A decrease of conductivity of the sensing electrode is correlated to the number of cavities or holes that are filled with, bound to, or occupied by, the molecules of the analyte. The invention exhibits numerous technical merits such as suitability for field application, high sensitivity to analyte such as PFOA or PFAS at 1 ppt level, rapid response within minutes, and superior selectivity against interferences such as PFDA, PFOS, PFOSA, and PFHxA, among others.

Abstract: The present invention relates to a Solid-Contact Ion-Selective Electrode (SC-ISE) and a method of producing a SC-ISE. The SC-ISE of the invention comprises at least one transition metal in a mixed redox state and is suitable for long-term deployment having a long term stability and thus limited need for calibration.

Abstract: A substrate has a first side and a second side vertically opposite to the first side. A sensing transistor is disposed at least in part over the first side of the substrate. A plurality of voltage reference transistors is disposed at least in part over the first side of the substrate. The voltage reference transistors are disposed on different lateral sides of the sensing transistor. A structure is disposed over the second side of the substrate. The structure defines one or more openings configured to collect a fluid. A sensing film is disposed over the second side of the substrate, wherein the sensing transistor is configured to detect, at least in part through capacitive coupling, a presence of one or more predefined miniature targets in the fluid that attach to the sensing film in the opening that is vertically aligned with the sensing transistor.

Abstract: A substrate has a first side and a second side opposite the first side. A first transistor has a first gate, a second transistor has a second gate, and a third transistor has a third gate. The first gate, the second gate, and the third gate are each disposed over the first side of the substrate. The second gate is disposed between the first gate and the third gate. The first gate and the third gate have different material compositions. A structure is disposed over the second side of the substrate. The structure includes a first opening aligned with the first transistor, a second opening aligned with the second transistor, and a third opening aligned with the third transistor. A sensing film is disposed over the second side of the substrate. The sensing film is configured to attach to one or more predefined miniature targets.

Abstract: A detector includes a first electrode, second electrodes forming a flow path for charged particles between the first electrode and the second electrodes, third electrodes configured to collect the charged particles, and a fourth electrode having a sheet resistance higher than sheet resistances of the second electrodes. The fourth electrode has one end portion having a first potential in a third direction and another end portion having a second potential lower than the first potential in the third direction, the fifth electrode included in the second electrodes is connected to the fourth electrode, the sixth electrode included in the second electrodes is connected to the fourth electrode, a seventh electrode included in the third electrodes is arranged side by side with the fifth electrode along a first direction, and an eighth electrode included in the third electrodes is arranged side by side with the sixth electrode along the first direction.

Abstract: Methods and apparatuses of identifying a type of material or material combination in a measurement location by Magnetic Induction Tomography (MIT) is disclosed. The methods can comprise providing a primary magnetic field primarily in a first direction into the measurement location; measuring an orthogonal component of a secondary magnetic field; classifying the orthogonal component of the secondary magnetic field with reference to a material or material combination type and thereby identifying a type of material or material combination in the measurement location. The orthogonal component of the secondary magnetic field is in a direction substantially orthogonal to the first direction.

Abstract: Method for ultrasonic characterization of a medium, comprising a step of generating a series of incident ultrasonic waves, a step of generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, a step of determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).

Abstract: There is a need for miniature, low power, and remotely powered sensors that can measure moisture and reactive gas content in the environment. Examples of devices that already exist include dew-point sensors, moisture sensors, and oxygen sensors. This disclosure describes the use of high-frequency ultrasonic pulses to interrogate thin films on the imaging surface of a CMOS integrated GHz Ultrasonic imager substrate. In one embodiment the device uses a Peltier cooler and heater chip to detect the dew point by the act of moisture condensing on the surface. Integrated temperature measurement is enabled by using some of the pixels, isolated from the environment, to be reflectors that measure the phase change in the reflected signal due to the change in the speed of sound in the silicon substrate. In another embodiment a thin film is exposed to gases, changing its ultrasonic impedance, which can be used to extract the film thickness and its ultrasonic properties.

Abstract: According to one embodiment, a detection device comprises a detector, a first propagating member, a second propagating member, and a fixture. The detector transmits an ultrasonic wave and detects a reflected wave. The first propagating member is mounted to the detector, and the ultrasonic wave propagates through the first propagating member. The second propagating member includes a second surface contacting a first surface of the first propagating member. The second surface includes a protrusion. The second propagating member is softer than the first propagating member. The ultrasonic wave propagates through the second propagating member after propagating through the first propagating member. The fixture presses a periphery of the second propagating member toward the first propagating member.

Abstract: A method of testing a substrate monolith (1), the substrate monolith (1) comprising: i) a plurality of channels extending longitudinally along a Z-axis of the substrate monolith (1); and ii) an array of walls extending along the Z-axis and forming partitions between adjacent channels; wherein the array of walls comprises first walls (10) orientated parallel to a first-axis of the substrate monolith (1) and second walls (11) orientated parallel to a second-axis of the substrate monolith (1), the first-axis and the second-axis both being orthogonal to the Z-axis; the method comprising the steps of: a) applying an impulse (J) to the substrate monolith (1) with an impact tool (22) to induce mechanical vibrations in the substrate monolith (1); b) sensing the mechanical vibrations of the substrate monolith (1); c) determining a fundamental frequency of the sensed mechanical vibrations; and d) comparing the fundamental frequency of the sensed mechanical vibrations to a fundamental frequency obtained from testing

Abstract: A scanning system for imaging structural features below the surface of an object, the scanning system comprising: a transducer module configured to transmit ultrasound signals towards an object and to receive ultrasound signals reflected from the object whereby data pertaining to an internal structure of the object can be obtained; and an analysis module coupled to the transducer module and configured to analyse received ultrasound signals to identify a feature in the received ultrasound signals; in which the transducer module is configured to transmit further ultrasound signals at a time delay t after the ultrasound signals, where the time delay t is determined in dependence on the identified feature.

Abstract: Examples of the present subject matter provide techniques for enhancing images taken from non-destructive inspection techniques, such as acoustic inspection. A source 3D data may be acquired representing an object. Rather than displaying the source 3D data, signal processing may be employed to enhance the flaws or defects in the source 3D data. A geometry template of the object may be created using the source 3D data. The source 3D data may be compared to the geometry template, and based on the comparison, an enhanced 3D image may be generated.

Abstract: Provided is an ultrasonic inspection device and method capable of generating a clear image of a desired bonding interface without an S-Gate. The controller in the ultrasonic inspection device is configured to: (A) define a first gate indicating a time range in which a part of a reflected wave is extracted based on a predetermined condition received; (B) define one or more second gates each indicating a time width smaller than that of the first gate before an end time of the first gate; (C) for each of a plurality of measurement points of an inspection object, (C1) detect a lower layer echo or a local peak, (C2) adjust a reception time of the reflected wave based on the lower layer echo or the local peak; and (D) generate a cross-sectional image of the inspection object based on the reflected wave.

Abstract: This disclosure relates to the field of corrosion and erosion monitoring of pipes and vessels. More specifically, this disclosure relates to a system and method for corrosion and erosion monitoring of pipes and vessels, where the system/method combines ultrasonic thickness monitoring using longitudinal waves with ultrasonic area monitoring using one or more guided waves, whereby representative thickness measurements are complemented by an area monitoring feature to detect localized corrosion/erosion in between representative thickness measurement locations. In another embodiment, a system and method for optimized asset health monitoring that includes an analytics solution is disclosed.

Abstract: An ultrasonic transducer for high temperature application forms part of ultrasonic wall thickness measurement system. The ultrasonic transducer has a modular design. The ultrasonic transducer has a modular design which enables the selection of piezoelectric element type based on field applications without changing the manufacturing process and redesigning of other components. A temperature sensor can be provided as part of the ultrasonic transducer. Methods of assembly are also provided.

Abstract: An automated solution-phase synthesizer is provided with an automatic sample injection system, an assisting system for solution-phase synthesis, an automatic online monitoring system for solution-phase synthesis and a master computer. The automatic sample injection system completes an automatic sample injection operation according to a sample injection instruction from the master computer. The assisting system for solution-phase synthesis controls temperature and illumination of a solution to undergo reaction according to a temperature control instruction and an illumination control instruction from the master computer. The automatic online monitoring system for solution-phase synthesis monitors a reaction solution and generates a monitoring report. And, the master computer generates an experimental analysis result according to the monitoring report.

Abstract: A rod-style linear actuator for use with a housing associated with an axially-rotatable hollow internally-threaded shaft and a piston-driven device is provided where small, precise movement is necessary. The actuator includes a body, a lead screw engaging the axially-rotatable hollow internally-threaded shaft and terminating in a piston, and an anti-rotation device extending from to the lead screw and engaging one of the body or an opposing second body.

Abstract: An installation device is for installing a sample separating device for separating a liquid sample in a sample separating tool. The installation device includes a first fluid connection for fluidically connecting to a first fluid connection point of the sample separating device, and an actuation device that can be actuated by a user for converting between an access position and a fluid coupling position. The access position makes the sample separating device accessible to the user, and the fluid coupling position fluidically couples the sample separating device. The installation device also includes a fluid coupling mechanism, which forms a force-loaded fluidic connection between the first fluid connection and the first fluid connection point when the sample separating device is converted into the fluid coupling position by the actuation device. The sample separating device may, for example, be configured for chromatography.

Abstract: The invention relates to simplifying calibration of gas sensors, including gas sensors which are portable and for home use, consumer use or medical use including breath gas sensors, where the calibration against samples of a measured gas having a concentration above the null value, is only performed once to establish a set of calibration ratios of measured known gas concentration readings over null sample readings. Thereafter, in use, the ratio of unknown gas concentration in a test sample to a null value (preferably ambient air) is determined without recalibration, and that ratio is compared with the set of calibration ratios to determine the unknown gas concentration by interpolation or extrapolation.

Abstract: Embodiments are described of a sensing network including one or more sensor nodes, wherein each of the one or more sensor nodes includes a gas sensor that can measure the presence, concentration, or both, of one or more airborne pollutants in a nodal coverage area surrounding the sensor node. A sensor base that can measure the presence, concentration, or both, of one or more airborne pollutants is positioned in the nodal coverage area of each of the one or more sensor nodes, wherein the sensor base includes a gas sensor with higher accuracy, higher sensitivity, or both, than the gas sensors of the one or more sensor nodes. One or more servers communicatively coupled to the sensor base and the one or more sensors nodes. The sensor base and the sensor nodes can communicate their measurements to the server and the measurements of the sensor base are used by the server as a reference to correct the measurements of the one or more sensor nodes.

Abstract: An air quality determination method including a temperature control step, an acquisition step, a determination step, and an output step. The temperature control step includes controlling a temperature of a sensitive unit exposed to a sample gas to cause the temperature of the sensitive unit to vary in a temperature variation pattern including at least one temperature rising period in which the temperature of the sensitive unit rises and at least one temperature falling period in which the temperature of the sensitive unit falls. The acquisition step includes acquiring an electrical characteristic value of the sensitive unit exposed to the sample gas. The determination step includes determining, using a learned model to determine an air quality condition of the sample gas, the air quality condition of the sample gas based on a variation in the electrical characteristic value. The output step includes outputting a decision made in the determination step.

Abstract: The present disclosure is directed to a gas sensor device that detects gases with large molecules (e.g., a gas with a molecular weight between 150 g/mol and 450 g/mol), such as siloxanes. The gas sensor device includes a thin film gas sensor and a bulk film gas sensor. The thin film gas sensor and the bulk film gas sensor each include a semiconductor metal oxide (SMO) film, a heater, and a temperature sensor. The SMO film of the thin film gas sensor is an thin film (e.g., between 90 nanometers and 110 nanometers thick), and the SMO film of the bulk film gas sensor is an thick film (e.g., between 5 micrometers and 20 micrometers thick). The gas sensor device detects gases with large molecules based on a variation between resistances of the SMO thin film and the SMO thick film.

Abstract: A method for estimating moisture content of a gas mixture in a Sample Handling System includes receiving data comprising measurements, and a plurality of parameters related to the gas mixture; analyzing the data to remove one or more anomalies; and calculating a surface area of the gas cooler based on the analyzed data and a determined thermodynamic properties, heat transfer coefficient and mass transfer coefficient of the gas mixture to estimate the moisture content of the gas mixture at an inlet and outlet of a gas cooler.

Abstract: A feedback-based system and method that identifies characteristics of one or more cells and utilizes the characteristics to initiate and adjust a field applied to the one or more cells to control the cells' functioning and motility is provided. Machine learning can be leveraged to automatically identify characteristics of the one or more cells and adjust the parameters of the field based on the characteristics. Sensors are utilized during the application of the field to monitor characteristics of the one or more cells and parameters of the field. Specifically, characteristics of at least some of the cells are measured at different points, and the measurements are used to determine whether the desired effect has been achieved or whether unintended consequences are taking place. Based on the measurements, parameters of the field can be adjusted to achieve the desired effect on cell functioning, cell motility, or both.

Abstract: A method to evaluate source rock richness is claimed. The method includes obtaining a source rock sample, collecting pyrolysis data from testing of the sample, filtering the pyrolysis data to produce a filtered pyrolysis data set, extracting a plurality of elements from their respective oxides and cross-checking the filtered pyrolysis data set with the plurality of elements. The method further includes discarding a plurality of unreliable data points from the filtered pyrolysis data set to produce a cross-checked data set, matching the cross-checked data set with wireline log data, determining a minimum value and a maximum value of the wireline log data that are within the cross-checked data set, and collecting depth thicknesses corresponding to the minimum value and the maximum value. The method also includes calculating a sum of the plurality of depth thicknesses, calculating a net source rock thickness, and calculating a corresponding average total organic carbon value.

Abstract: A method for the classification of geological materials into similar facies includes: determining the elemental metric for each geological sample from a geographical location; determining a colour metric for each geological sample from a geographical location; setting an initial classification framework based on the availability and quality of the colour metric; using the initial classification framework as the target for a machine learning process; applying the trained machine learning process on geological samples from another geographical location for the classification of said geological samples from another geographical location.

Abstract: A computer receives a measured wetness of and a measured ?2H value associated with a test gas sample from a hydrocarbon formation. The measured wetness is a molar ratio of heavy gas compounds over a total gas within the measured sample. The computer receives calculated wetnesses calculated ?2H values associated with a gas samples taken from one or more analogous hydrocarbon reservoirs. The measured wetness received for the test gas sample is identified from among the plurality of calculated wetnesses. The computer determines a corresponding ?2H value from among the calculated ?2H values that corresponds to the measured wetness of the test gas sample. The computer determines a predicted sample VRo (vitrinite reflectance equivalent) for the test gas sample based on the corresponding ?2H value and a correlation of ?2H values to VRo values. Hydrocarbons are produced from the hydrocarbon formation based on the predicted sample VRo.

Abstract: Processes for quantitating the corrosivity of naphthenic acids in a sample comprising crude oil or a liquid fraction thereof by reacting the sample with a metal comprising iron to produce iron naphthenates that are then stabilized by a ligand. The stabilized iron naphthenates are then analyzed by mass spectrometry to accurately quantitate the percentage of total naphthenic acids in the sample that are iron-reactive naphthenic acids associated with metal corrosion.

Abstract: The present disclosure provides systems and methods for the identification of dysbiotic biological samples.

Abstract: Disclosed herein is a composition that involves a nanopore disposed in a membrane preparation, wherein the nanopore has an outer membrane protein G (OmpG) having 8 to 22 ?-strands connected by a plurality of flexible loops on a first side of the membrane preparation and a plurality short turns on a second side of the membrane preparation, wherein a heterologous peptide is inserted within one or more of the flexible loops. Also disclosed herein is a method of detecting binding of a ligand to a target, the method involving: exposing a nanopore composition disclosed herein to a target; assessing a gating pattern of the nanopore; and detecting binding of the target to the heterologous peptide based on the gating pattern.

Abstract: A method of measuring stable hemoglobin A1c by a hemoglobin separation analysis method based on cation exchange, the method comprising: obtaining an analysis signal from a blood specimen to be measured by the separation analysis method; determining a C value, which is a peak value of a stable hemoglobin A1c peak, and an X value, which is a peak value of a specific peak appearing between the stable hemoglobin A1c peak and a hemoglobin A0 peak, from the analysis signal; and correcting the C value by applying the C value and the X value to a predetermined arithmetic expression to obtain a C? value that is a reduced value from the C value, wherein the arithmetic expression is determined based on a correlation between a C value and an X value obtained from a blood specimen in which a stable hemoglobin A1c value is known by the separation analysis method.

Abstract: Non-limiting embodiments of a system(s) of generating interfering flags to reduce false diagnosis due to interfering conditions present in urinalysis results, and method(s) related thereto.

Abstract: Method and system for self-assessment of drinking behavior. According to one embodiment, the method includes examining a transdermal alcohol response curve obtained from a drinking event, querying a user on their feelings of intoxication after or during the event, and using the combination of the objective measurement and subjective feelings of intoxication to provide an alert or status during subsequent drinking events. In so doing, the method mitigates at least some of the drawbacks associated with conventional alcohol monitoring devices by correlating an individual's reported feelings of intoxication with an objective transdermal measurement of alcohol.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: A method is disclosed herein to reconstruct and mimic the in vivo pattern of exposure to the active substances included in the drug treatment regimen in vitro using a cell assay. Means and methods for converting an in vivo pattern of exposure to appropriate concentrations, durations of exposure and time points of addition for an in vitro assay.

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.

Abstract: The invention relates to a method for screening of at least one chemical substance by treatment of plant material, comprising the following process steps: a) Applying the plant material into a cavity; b) Treatment of the plant material with the chemical substance; c) Creating at least one dataset showing at least one phenotypical characteristic of the plant material after treatment with the chemical substance; and d) Assigning the chemical substance based on the dataset to at least one site of action (SoA) and/or at least one mode of action (MoA) of a multitude of stored SoA and/or MoA by using a SoA- and/or MoA-compendium containing data regarding dependencies between phenotypical characteristics of at least one plant material treated by at least one reference substance of a known SoA and/or MoA.

Abstract: Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions, systems, and kits for detecting analytes using fluorogenic probes and multiplex technologies.

Abstract: An immunoassay device and an immunoassay method are provided. The immunoassay device includes: a housing, a driving assembly, a detection chip and a liquid storage chamber; the housing has a first accommodating part in which the detection chip is disposed and a second accommodating part in which the liquid storage chamber is disposed, and the liquid storage chamber is configured at least to store reagent; the driving assembly is configured to communicate a liquid outlet of the liquid storage chamber with a liquid inlet of the detection chip, and drive the reagent in the liquid storage chamber to enter the detection chip.

Abstract: A fluidic cartridge module includes a casing, a biosensor package, and a fluidic channel. The casing includes a sample inlet and a buffer inlet, a biosensor package disposed in the casing and comprising a sensor array and a reference electrode. The fluidic channel is disposed over the biosensor package and connected to the sample inlet and the buffer inlet, wherein the fluidic channel includes a first opening aligned with the sensor array and a second opening aligned with the reference electrode.

Abstract: A localized surface plasmon resonance biosensing device is disclosed, including a laser source; a first linear polarizer configured for linearly polarizing probe laser; a plasmonic microarray biochip configured for receiving the linearly polarized probe laser; a photothermal excitation assembly configured for outputting an optical wave acted on an optical waveguide array of the plasmonic microarray biochip; an optical interference assembly configured for converting laser transmitted by the plasmonic microarray biochip into double beams meeting an interference condition; a telecentric lens; and an imaging chip configured for acquiring a laser speckle image formed by interference of the double beams.

Abstract: Described are sensing devices and methods for detecting at least one analyte in a sample solution. The sensor is capable of a pre-storage state, a storage state and a sensing state. The sensor includes at least one substrate-adjacent aptamer; where the sensor, in the absence of a material to reduce or prevent degradation, would incur significant degradation when the sensor is placed in a storage state. The sensor further includes at least one material which reduces or prevents the significant degradation during the storage state.

Abstract: Provided is an easy to determine immunochromatography detection device that detects a target substance that may be contained in a sample fluid. The detection device includes a flow path for the sample fluid and detection parts 1 to which capture selected substances. In one embodiment, an Metal-Insulator-Metal (MIM) structure is formed when the target substance is included in the sample fluid at the detection parts, and a color is produced at the detection parts by resonance absorption. The MIM structure comprises a metal thin film (M layer) that is formed on a support that acts as either a capture substance/target substance/reference substance composite layer or a capture substance/reference substance composite layer (I layer), and metal fine particles (M layer) with which a reference substance is labeled.

Abstract: The present disclosure generally provides methods for identifying compounds that enhance kokumi taste, and related uses. In some particular aspects, the disclosure provides methods of identifying compounds that enhance kokumi taste by determining whether the compounds modulate the T1R1/T1R3 taste receptor. In some other aspects, the disclosure provides uses of such identified compounds to enhance the kokumi taste of an ingestible composition. In some further aspects, the disclosure provides flavored products, such as food or beverage products, that incorporate such ingestible compositions, and which thereby impart or enhance an umami taste in a flavored article. In some other aspects, the disclosure provides ingestible compositions that contain compounds known to impart or enhance umami taste, such as glutamates, aspartates, and purinic ribonucleotides, such as inosine monophosphate (IMP) and guanosine monophosphate (GMP).

Abstract: Methods disclosed herein are directed to methods of detecting and/or quantifying an antigen. The ultrasensitive Click chemistry Amplified Nanopore (CAN) assay has been engineered for antigen quantification in a biological sample. According to the present disclosure, the CAN assay is based on the combination of an amplified sandwich assay and nanopore sensing. Methods disclosed herein may be incorporated into a point-of-care test device with the necessary accuracy, portability, cost efficiency, and simplicity to fill the diagnostic gaps in high infectious disease burden areas.

Abstract: The present disclosure relates to a method for identifying cells that express antigen-specific antibodies with a high binding affinity for a monomeric antigen. Using fluorescence activated cell sorting, cells expressing high affinity antigen-specific antibodies are selected from a population of immune cells isolated from a mammal that has been immunized with or otherwise exposed to the antigen. Nucleic acids encoding the high affinity antibodies can then be cloned into other lymphoid and non-lymphoid cells where the antibody can be expressed and from which the antibodies can be secreted.

Abstract: The present document describes a dual-affinity probe comprising an organic or inorganic surface binding peptide and a target-specific capture element, which may bind to various targets, such as pathogens. This document further describes uses of the dual-affinity probe, and kits to determine the presence of and/or quantity of a target in a sample. In particular embodiments, the dual-affinity probe is specific for SARS-CoV-2 (Spike or Nucleocapsid) protein and may be used to determine whether a subject is infected with SARS-CoV-2.

Abstract: Methods and compositions for accurate blood biomarker panel-based detection of cancer, e.g., breast cancer, and sub-typing, e.g., using ultrasensitive immunoassays, e.g., digital ELISA.

Abstract: The present invention relates to a method for predicting a prognosis of a lung adenocarcinoma patient. The present invention relates to a method for predicting a prognosis of a lung adenocarcinoma patient after cancer resection. The present invention also relates to a method for treating a lung adenocarcinoma patient.

Abstract: The present invention provides a method of identifying a metastatic castration resistant prostate cancer (mCRPC) patient with an improved response to taxane therapy compared to androgen receptor (AR) targeted therapy comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to generate circulating tumor cell (CTC) data, wherein the analysis comprises detecting the presence of an Androgen Receptor Variant 7 (AR-V7) in said cells, and (c) evaluating the CTC data to identify a mCRPC patient with an improved response to taxane therapy compared to ARS-directed therapy therapy.