Abstract: The present invention is provided with an electrolyte measurement unit 11, a second measurement unit for performing measurement of a different measurement item to the electrolyte measurement unit 11, a sampling mechanism 5 for dispensing a sample to the electrolyte measurement unit 11 or the second measurement unit, and a control unit 13 for controlling the operation of respective devices. When the sample is dispensed to the second measurement unit by the sampling mechanism 5 or measurement of the sample is performed by the second measurement unit, the control unit 13 measures the potential in a state in which ion-selective electrodes 104, 105, and 106 are filled with an internal standard liquid, and determines, on the basis of measured data, whether or not there is an abnormality in the electrolyte measurement unit 11.

Abstract: The present invention relates to a Cu ion sensor, which greatly improves the sensitivity to Cu by a nitrogen-rich surface of a copper nitride thin film doped with a metal material. The present invention also relates to a Cu ion sensing method, in which Cu2+ is detected by contacting the Cu ion sensor of the present invention with the solution to be tested, and using the change in electrical conductivity of a copper nitride film doped with a metal material in the presence of Cu2+ in the solution.

Abstract: An internal detection system of stress concentration of an oil and gas pipeline based on unsaturated orthogonally magnetization is provided. The system comprises a detection device and a processing device; the detection device comprises a detection probe; the detection probe comprises a magnetizing device and a magnetic signal acquisition device; the magnetizing device is fixedly connected with the magnetic signal acquisition device; the magnetizing device is configured to magnetize a pipeline to be detected, so that the pipeline generates a magnetized magnetic field; the magnetic signal acquisition device is configured to acquire a magnetic signal of the magnetized magnetic field to obtain an acquired signal and send the acquired signal to the processing device; the processing device is configured to receive the acquired signal and obtain a stress concentration area of the pipeline based on the acquired signal.

Abstract: A method of making a sensor comprises depositing a plurality of surface-associated compositions on a piezoelectric base. The plurality of surface-associated compositions are adapted to stably associate with the piezoelectric base. The method further comprises depositing a plurality of crosslinking compositions on top of the surface-associated compositions. The crosslinking compositions are configured to bind to an analyte and crosslink one or more of the surface-associated compositions when the analyte binds to an analyte binding domain of a crosslinking composition and the surface-associated compositions include one or more polyclonal antibodies.

Abstract: A field device comprising first and second tines; first and second rods coupled to the first and second tines; a coil arrangement fixed to the first rod; a magnet fixed to the second rod, opposite the coil arrangement; excitation circuitry coupled to the coil arrangement and controllable to provide a time-varying current to the coil arrangement, resulting in vibration of the first tine in relation to the second tine; sensing circuitry coupled to the coil arrangement and configured to provide a sensing signal indicative of a change in at least one property of the vibration of the first tine in relation to the second tine; and measurement control circuitry coupled to the excitation circuitry and the sensing circuitry for controlling operation of the excitation circuitry.

Abstract: A tapping inspection system includes a hand-held hammer, a display, a device, a position detection unit and a storage. The hammer is for tapping an inspection portion. The display is configured to display a target position to be tapped with the hammer. The target position is superimposed on the inspection portion. The device is for collecting sound generated when the inspection portion is tapped with the hammer. The position detection unit is configured to detect a position in the inspection portion tapped with the hammer. The storage is configured to store an inspection record created by relating the sound collected by the device with the position detected by the position detection unit.

Abstract: A system and method perform automated detection, classification, and remediation of defects in a structure using ultrasound testing. The system includes an autoencoder is trained and configured to generate a de-noised UT scan image from a noisy UT scan image of a structure, a support vector machine configured to detect a defect in the structure, a convolutional neural network configured to classify the defect, and a remediation subsystem configured to remediate the defect. The method implements the system.

Abstract: A system and method for sizing defects in solid structures using guided waves. The system includes a magnetostrictive-strip EMAT transducer comprising at least one biasing static magnetic field, at least one RF coil for fixed-wavelength measurements, at least one RF coil for variable-wavelength measurements, and a strip of highly magnetostrictive material that is coupled with the structure. The fixed-wavelength RF coil permits obtaining measurements of amplitude and frequency content of signals reflected and/or attenuated when traveling through the structure which are used to estimate the size and geometry of any defects in this structure. The variable-wavelength RF coil permits recording the frequencies that are cut off or pass through the structure to also estimate the size of any defects in the structure. The fixed-wavelength sizing and geometry assessment is used to determine whether the variable-wavelength estimate is valid.

Abstract: A method for determining tobacco-specific nitrosamines (TSNAs) in cigarette smoke using one-step clean-up coupled with LC-MS/MS is provided, including the following steps: collecting a particulate matter of mainstream cigarette smoke with a Cambridge filter pad, mixing the particulate matter of mainstream cigarette smoke, an internal standards solution and water in a 50 mL plastic centrifuge tube, and vortexing the resulting mixture at room temperature to allow extraction; transferring an extraction solution after filtration to a new centrifuge tube, adding dichloromethane, and vortexing the resulting mixture; centrifuging to collect a dichloromethane extraction solution in a lower layer to another centrifuge tube, and placing the centrifuge tube in a water bath to remove dichloromethane; dissolving the resulting extraction solution in water, and transferring the resulting solution to an autosampler vial for LC-MS/MS analysis.

Abstract: A thermostat arrangement for a sample separation device for separating a fluidic sample includes a separation unit thermostat unit for adjusting a temperature of a separation unit for separating the fluidic sample in a mobile phase, a sample handling unit thermostat unit for adjusting the temperature of a sample handling unit for handling the fluidic sample, and a thermal coupling unit for thermally coupling the separation unit thermostat unit with the sample handling unit thermostat unit.

Abstract: The present disclosure relates generally to a chromatography column adaptor for forming a fluidic connection between a chromatography column and a GC component. The present disclosure also relates to fluidic connections for a gas chromatography system.

Abstract: A GC assistance device includes a saving amount evaluator, a consumption amount evaluator and an outputter, and is used together with a gas chromatograph. The saving amount evaluator evaluates a saving amount of a resource caused by stopping of the gas chromatograph. The consumption amount evaluator evaluates a consumption amount of the resource caused by recovery of the gas chromatograph from a stop state. The outputter presents an evaluation value in regard to the saving amount and the consumption amount to a user. Alternatively, the outputter controls an operation state of the gas chromatograph based on the evaluation value.

Abstract: Apparatus and methods for detecting and reporting pollution at an oil facility are disclosed. The technology utilizes a logic control system to read from a pollution sensor and present the sensed data as a pollutant from a leak. The pollution leakage can be further managed and reduced.

Abstract: A gas identification method uses a sensor for outputting a signal corresponding to an adsorption concentration of a gas, and includes: acquiring a signal output from the sensor that is exposed to a sample gas only during a second period out of a measurement period including a first period, the second period following the first period, and a third period following the second period; extracting one or more feature quantities corresponding to the drift of the signal acquired; and, identifying the sample gas based on the one or more feature quantities extracted, using a learned logical model for identifying the sample gas, and outputting an identification result.

Abstract: The present invention relates to a method of increasing the volatile organic compound (VOC) emissions in a ruminant, said method comprising the administration of a methane inhibitor to said ruminant. The increase in the VOC emissions can be used for monitoring and/or quantifying the reduction of methane emanating from the digestive activities of the ruminant affected by the feeding of said methane inhibitor.

Abstract: An apparatus for monitoring inerting in an exhaust gas discharge of a production facility includes a first flow measuring unit; a second flow measuring unit, and a monitoring unit. The first flow measuring unit is connectable to a first flow meter arranged in a first supply line of a first gas to the production facility and the second flow measuring unit is connectable to a second flow meter arranged in a second supply line of a second gas to the exhaust gas discharge. The first flow measuring unit determines a first gas quantity supplied to the production facility and the second flow measuring unit determines a second gas quantity of the second gas supplied to the exhaust gas discharge. The monitoring unit triggers a safety-related control function based on the determined first and second gas quantity.

Abstract: Embodiments relate generally to a gas detector test fixture that recycles test gas. A portable gas detector test fixture, comprises a test chamber, a processor, a docking connector communicatively coupled to the processor, an output device communicatively coupled to the processor, a memory communicatively coupled to the processor, and an application stored in the memory that, when executed by the processor, is configured to conduct a bump test on a portable gas detector plugged into the docking connector and to output the bump test result to the output device. The test fixture further comprises an inflow line configured to connect to a test gas supply line of a test gas container, where the inflow line is coupled to the test chamber, and an outflow line configured to connect to a test gas return line of the test gas container, where the outflow line is coupled to the test chamber.

Abstract: Systems, units and methods for monitoring water of at least one swimming pool (SP) by: obtaining non-manipulation data of the SP water or one or more samples thereof before/without applying any manipulation to water of the SP sample(s) thereof; applying at least one manipulation over the SP water or one or more samples thereof; obtaining manipulation data of the SP water indicative of responsivity of the SP water or one or more samples thereof to each manipulation applied thereto, using one or more sensors; and analyzing the non-manipulation and manipulation data to determine one or more characteristics of the SP water including for example concentration of one or more substances in the SP water. In some embodiments, at least one manipulation may include dechlorination of the SP water.

Abstract: An indicator composition can be used to measure calcium hardness within a sample of water from a process water system. The indicator composition can include a calcium indicator, a range extender, and a buffer. The indicator composition can accurately measure calcium concentrations within the sample of water at low, moderate, and high calcium levels, including at calcium concentrations of greater than 50 ppm. The indicator composition can measure calcium hardness without the use of masking agents at a pH of less than about 7.

Abstract: An automated wetstock management system can include a plurality of sensors disposed in a fuel storage facility, the plurality of sensors configured to sense fuel data characterizing one or more aspects of the fuel storage facility, and a wetstock management server communicatively coupled to the plurality of sensors. The wetstock management server can process the fuel data to detect whether the fuel data satisfies an exception indicative of an operational issue of the fuel storage facility based on one or more predefined rules or models stored in the wetstock management server. In some embodiments, the wetstock management server can generate a workflow for assisting a user of the fuel storage facility to resolve the operational issue. In some embodiments, the wetstock management server can assign a risk category to the exception and electronically transmit an alert characterizing the operational issue to the user.

Abstract: A method to perform a field operation with digital cement modeling is disclosed. The method includes acquiring computed tomography (CT) scan data of a metal-cement core sample and a cement-rock core sample that are associated with a borehole setup, generating, based on the CT scan data of the metal-cement core sample and the cement-rock core sample, a three-dimensional (3D) image of a synthesized metal, cement, and rock core sample, generating, by at least upscaling the synthesized metal, cement, and rock core sample, a multi-scale borehole digital model of the borehole setup, and calculating, using the multi-scale borehole digital model of the borehole setup and based on digital rock physics techniques, a predicted cement longevity.

Abstract: A method of selecting a treatment recommendation for nitrogen loss in a field includes measuring a first characteristic of a soil sample that is related to biologic nitrogen loss to produce a measured value. A second characteristic of the soil sample is measured and is used to select a sample group for the soil sample. The measured value is scaled based on the soil sample group the soil sample is placed into to form a scaled measure and the scaled measure is used to select a treatment recommendation.

Abstract: A device for detecting soil nutrients on site, including an extracting grid, an on-site real-time detection assembly and a transfer assembly for transferring a soil extract from the extracting grid to the on-site real-time detection assembly. A soil nutrient detection method using the device and a microfluidic chip are also provided. The microfluidic chip includes a cover plate and a base plate. The base plate includes a soil extract feeding groove, a quantitative feeding groove, a reagent storage groove, and a serpentine groove.

Abstract: A method of indicating a characteristic of a soil sample of a field includes measuring a co-factor in the soil sample and using the co-factor to place the soil sample in a soil sample group. The characteristic of the soil sample is measured and then is scaled based on the soil sample group. The scaled measure is displayed to better represent the characteristic of the soil sample relative to soil samples of the sample group.

Abstract: A system of soil carbon measurement is provided. The system includes a multimodal sensor payload that includes multiple sensors that are each a different sensor type and that are configured to estimate quantities of carbon stored in a soil area. The sensors include multiple stand-off sensor technologies.

Abstract: Method of characterizing the chemical signature of petroleum oil contained in reservoir rock for the purpose of production allocation, estimation of vertical drainage, and monitoring of production. Reservoir rock samples from petroleum pay zones are cleaned from surface contaminations, and then loaded with water into pressure vessels and seals to airtight. The vessels are heat treated with elevated pressure to release trapped oil. Oil is extracted from the products from the vessels and analyzed for chemical compositions. The measured compositions of extracted oils are used to construct geochemical fingerprinting for the characterization of fluid-in-place in the pay zones.

Abstract: A device measuring the fineness and/or maturity of cotton fibers contains a measuring chamber accommodating a cotton fiber sample and a tubular plunger. The measuring chamber extends between a first end closed by a wall having one or more vent holes and a second end opposed to the first end and hermetically closed. The plunger penetrates within the measuring chamber through the second end to run at least two strokes of predetermined lengths and has an inner channel extending between a tail portion and a perforated head portion placing the inner channel in fluid communication with the measuring chamber. The device further contains a reservoir placed upstream of the inner channel and in fluid communication with the inner channel; a pump filling the reservoir with air from an environment; and a flow regulator placed downstream of the reservoir and upstream of the inner channel.

Abstract: A building material apparatus includes at least one building material transport part which follows a building material drum, wherein the building material transport part is designed to transport building material which is to be at least partially cured, and at least one part sensor. The part sensor is arranged on and/or in the building material transport part and is designed to detect at least one intensive variable, or at least one variable which corresponds at least to the intensive variable, of the building material in the building material transport part.

Abstract: The present disclosure relates to a device comprising a unit having an interior aqueous environment surrounded by a lipid layer, wherein the lipid layer comprises an olfactory receptor, wherein the unit is attached to the device via a hydrophobic force, wherein the device is configured to capture a volatile organic compound (VOC) onto the olfactory receptor. Further, the present disclosure also relates to the method and device comprising an artificial olfactory sensing system.

Abstract: The present disclosure provides a composition comprising a solid support, a plurality of tethered oligonucleotides attached to the solid support, and a plurality of untethered oligonucleotides hybridized to the tethered oligonucleotides. An untethered oligonucleotide can comprise, attached via the 5? end, a cell, or an effector molecule. Hybridization of an untethered oligonucleotide to a tethered oligonucleotide generates an enzyme cleavage site, which allows for temporally controlled removal of an effector molecule. The present disclosure provides methods of temporally modulating the activity and/or phenotype of a cell. The present disclosure provides a solid support comprising patterned tethered oligonucleotides attached thereto; and methods of making the solid support.

Abstract: Embodiments of the disclosure concern methods and compositions related to optimization of selection of cord blood units to produce immune cells, such as NK cells, for adoptive cell therapy use. In specific embodiments, particular characteristics of the cord blood units and/or characteristics of cells derived therefrom are analyzed. When a threshold measurement for one or more characteristics is met for the cord blood unit(s) and/or characteristics of cells derived therefrom, the cord blood unit(s) are utilized as a source for production of immune cells. Specific characteristics for measurement include cord blood cell viability, total nuclear cell recovery, and nucleated red blood cell content, each prior to cryopreservation, and optionally cytotoxicity and/or expansion of immune cells subsequent to cryopreservation.

Abstract: The present invention is directed to a method for determining the suitability of a subject to TNF? inhibitor therapy. Further provide is a method for treating a subject afflicted with a TNF? related disease.

Abstract: The present invention provides drug toxicity evaluation platforms (such as an evaluation method and a kit therefor) that enable detailed analysis of the possibility and the like of developing drug-induced damage (such as DILI) to the liver and other organs. The method for evaluating drug toxicity of the present invention includes: a step of adding a drug to a co-culture system of an organoid and blood cells; and a step of evaluating the toxicity of the drug to the organoid.

Abstract: Provided are methods for modulating a SRC-1 condensate to regulate transcription of one or more genes, methods of treating diseases and conditions using SRC-1 inhibitors, and methods for screening of agents that modulate SRC-1 condensate.

Abstract: This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost reductions in the drug discovery process resulting from the corresponding increases in efficiency.

Abstract: Methods of studying eukaryotic cell responses to a perturbation, or of stratifying eukaryotic cells or cell lines into one or more subgroups are described. The methods involve perturbing a library of cells or cell lines in the same manner, and observing how the cells respond to the same perturbation. The observation may be via a high throughput screening method, for example, cell painting; and the perturbation may be, for example, exposure to a therapeutic agent. The methods may be used for grouping cells or cell lines that respond similarly to a given therapeutic agent, which may be useful for identifying patient groups and selecting appropriate treatments.

Abstract: The present invention relates to a reaction platform, which comprises: a machine body with a bottom plate for placing non-porous substrates; and a coater module configured on the top of the machine body and capable of maintaining a preset of a predetermined height for moving along the surface of non-porous substrate, wherein the coater module has one or more slits, and a target liquid can be directly injected or sucking in from the outside of the coater module through the slit, and spreading the target liquid onto a surface of the non-porous substrate while moving along the non-porous substrate; wherein the surface of the non-porous substrate has a target to be coated. The reaction platform of the present invention can not only save time, labor and cost, but also have accurate and reproducible experimental results, showing better results than traditional methods.

Abstract: The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.

Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.

Abstract: A bioassay, which is a segregative phase separation system (SPSS) where a bioassay signal intensifier is presented. The bioassay signal intensifier is an aqueous two-phase system (ATPS) component that causes the signal to intensify in one aqueous phase of a plurality of phases formed from the bioassay composition. The source of the signal resulting from the inclusion of a test sample is selectively partitioned into one phase that can be of significantly lesser volume than in the bioassay absent the bioassay signal intensifier, such the signal's source is concentrated in that phase, and the signal is intensified.

Abstract: Immobilization and magnetic extraction of pathogens and pathogen components The application describes a method for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. Specifically, the method relates to incubating the sample with superparamagnetic iron-based particles attached to a target binding peptide and immobilising the superparamagnetic iron-based particles with a magnetic field and thereby separating the pathogen-bound and/or pathogen component-bound superparamagnetic iron-based particles from the sample. Furthermore, the application relates to a method for identifying pathogens in an aqueous or body fluid sample a use of superparamagnetic iron-based particles for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. In addition, a use of superparamagnetic iron-based particles for identifying pathogens in an aqueous or body fluid sample is disclosed.

Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and comprise a capture agent for analyte detection and a substantially transparent magnetic polymer. The analog code is generated by a two-dimensional shape of a substantially non-transparent layer. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

Abstract: Devices, systems and methods for detecting target analyte molecules or particles in a sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample are disclosed.

Abstract: A sensor, a method of manufacture, and a method of use for detecting an analyte of interest in a fluid sample. The sensor may include a structure that may include a plurality of walls that define a plurality of air gaps in the structure, wherein the plurality of walls may include a plurality of surfaces. The sensor may further include a hydrophobic clickable layer, wherein the hydrophobic clickable layer may be coated on the plurality of walls. The sensor may further include a binding material, wherein the binding material may be coated on the plurality of walls to bind to an analyte of interest. An initial surface energy of at least a portion of the plurality of surfaces of the plurality of walls may change when the analyte of interest binds with the binding material.

Abstract: The present disclosure provides a sensing assembly for sensing an analyte. The sensing assembly comprises multiple test electrodes configured to provide signals from multiple independent measurements in response to the analyte. Alternatively or additionally, the multiple test electrodes are configured to produce different transient responses in response to a given concentration of the analyte.

Abstract: Some embodiments of the disclosure provide a method for detecting an anti-chimeric antigen receptor (CAR) antibody against humanized CAR T cells. In some examples, the method include following steps. S1. Transfecting a humanized CAR into Chinese hamster ovary (CHO) cells into using lentivirus to generate CHO cells expressing CAR as target cells. S2. Collecting samples to be tested. S3. Preparing different concentrations of standards using human proteins corresponding to a target of the CAR and establishing a standard curve. S4. Incubating the target cells with the different concentrations of standards and the samples to be tested, and capturing the anti-CAR antibody. S5. Incubating a phycoerythrin (PE)-conjugated anti-human IgG Fc antibody with CHO cells for labeling. S6. Calculating the anti-CAR antibody by detecting average fluorescence intensities of the standards, blank control, and the samples to be tested using flow cytometry.

Abstract: In some embodiments, a method includes applying an analyte to a rGO biosensor configured to bind to the analyte; applying a DC voltage to the rGO biosensor, wherein the DC voltage is +0.0008V to +0.005V for a negatively charged analyte; or ?0.005V to ?0.0008 for a positively charged analyte; and monitoring an electrical signal from the rGO biosensor for a response to the analyte.

Abstract: The present invention relates to a particle collection for detecting a pathogen-neutralizing molecule. The present invention further relates to a composition comprising a particle collection. The present invention also relates to a method of detecting a pathogen-neutralizing molecule. Furthermore, the present invention relates to a kit for detecting a pathogen-neutralizing molecule. The present invention further relates to a point-of-care device, and to a use of a particle collection or a composition in a method of detecting a pathogen-neutralizing molecule.

Abstract: In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.

Abstract: The problem addressed by the present invention is to provide an immunological assay method using a monoclonal antibody and a kit including the monoclonal antibody, which can be used for assaying ICTP without requiring special facilities. This problem can be solved by a method for immunological assay of type I collagen C-terminal telopeptide in a biological sample, including contacting type I collagen C-terminal telopeptide with a monoclonal antibody that recognizes an amino acid sequence represented by GFDFSFLP (SEQ ID NO: 1) as an epitope.