Abstract: Disclosed are compositions and methods to detect proteins associated with Head and Neck Cancer, generally, or more particularly, biomarkers of Head and Neck Squamous Cell Carcinoma (HNSCC). Such markers may be useful to allow individuals susceptible to HNSCC to manage their lifestyle and/or medical treatment to avoid further progression of disease.

Abstract: A stable isotope-labeled indole carboxylic acid compound represented by Formula (I) is provided. In Formula (I), X1 to X8 are each independently C or 13C; Y is N or 15N; M is H, Na, K, Li, CH3, or C2H5; R1 is H or D; R2 is H, CH3, 13CH3, C2H5, or 13C2H5; R3 is H, CH3, 13CH3, C2H5, or 13C2H5; R4 is H or D; and R5 is H or D.

Abstract: Provided herein are STING and SPARCS genes as biomarkers for determining an effective therapy for treating cancer. Further provided are methods for treating cancer using said biomarkers.

Abstract: A method of identifying the ALL molecular subtype with rearrangements within the KMT2A gene was disclosed, which consists in measuring the ratio of the intensity of the Raman 1040/1008 cm?1 Raman bands in leukemia cells (lymphoblasts) isolated from the peripheral blood (when blastosis >90%) or bone marrow of patients during the diagnosis of acute lymphoblastic leukemia, and fixed with an aldehyde reagent.

Abstract: The invention relates generally to hybrid amebocyte lysate compositions (including both native and recombinant components) and their use in detecting and/or quantifying endotoxin in a sample.

Abstract: A measurement system is disclosed which includes a spot-traversal system for causing relative motion between a sample and an irradiation spot in a first direction, wherein the sample includes one or more fluorescent markers having respective fluorescence wavelengths, a gating system configured to provide a gating signal based at least in part on resultant light substantially at a wavelength of the irradiation spot, and an optical detection system configured to detect fluorescent light from at least some of the fluorescent markers irradiated by the irradiation spot, and provide detection signal(s) representing the fluorescent light detected concurrently with a gate-open condition of the gating signal.

Abstract: A screening method for an amino acid sequence of a protein nanopore, a protein nanopore, and applications thereof. The screening method includes: evaluating a characteristic sequence of a dual-pore structure, using a model to search for an amino acid sequence matched with the characteristic feature of the dual-pore structure, removing a redundant candidate sequence and then performing positioning and screening, calculating the matching length and envelope length of the candidate sequence, then performing registration to obtain a relative mismatching relationship with a known protein nanopore, and performing analysis to obtain a final sequence.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

Abstract: A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of A?1-42 (SEQ ID NO.: 9), A?1-38 (SEQ ID NO.: 11), A?1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-A?1-42, SIL-A?1-38, SIL-A?1-40, and SIL-APP669-711.

Abstract: Disclosed herein are methods for identifying physicochemical properties associated with protein corona formation at the level of proteins and NP-functionalization. Further disclosed herein are compositions comprising combinations of particles configured for low abundance protein collection and deep proteomic analysis.

Abstract: A method and kit is described for the detection of a biomarker in a sample, by light scattering microscopy. The invention is particularly useful for the detection of low abundance biomarker in complex samples, and is suitable for use in a point of care setting. In an embodiment, the method of the invention describes detection of a biomarker in a sample using mass photometry.

Abstract: The invention provides compositions and methods for quantifying cellular molecules of interest, e.g., intracellular proteins, using oligonucleotide-target binding moiety conjugates.

Abstract: A method for screening a functional material according to the present invention comprises steps of: treating a linker material-coated substrate with a capture protein; treating the capture protein-treated substrate with a functional material candidate; treating the functional material candidate-treated substrate with biotin-conjugated IgE; and treating the biotin-bound IgE-treated substrate with fluorescently labeled streptavidin.

Abstract: Disclosed herein are methods for diagnosing a subject with loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia.

Abstract: Nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker, and methods for rapid diagnosis of lung conditions using specified panels of target biomarkers.

Abstract: The present invention relates to a marker for diagnosing non-alcoholic fatty liver disease and, more specifically, to: a composition and a kit which can diagnose non-alcoholic steatohepatitis (NASH) with high accuracy by comprising an agent for measuring the level of exosome-derived ApoA-1 (exosomal ApoA-1) protein; and a composition and a kit which can accurately predict prognosis after the administration of a therapeutic agent for non-alcoholic steatohepatitis. The composition and the kit of the present invention can be variously used for the diagnosis of non-alcoholic fatty liver disease, for the prognosis prediction of non-alcoholic fatty liver disease and as an agent for screening for therapeutic agents for non-alcoholic fatty liver disease.

Abstract: A method of immunoassay for detecting and/or monitoring esophageal fibrosis and/or dysphagia in a patient and/or assessing the likelihood of or the severity of esophageal fibrosis and/or dysphagia in a patient by contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of the C5 domain of the ?3 chain of type VI collagen.

Abstract: BLR-200 prevented and treated fibrosis in bleomycin-induced SSc fibrosis, as indicated by impairment of skin thickening, collagen deposition, and myofibroblast activation. BLR-200 treatment prevented bleomycin-induced CCN1 and CCN2 expression. Through single-cell RNA-sequencing analysis, and spatial gene analysis of tissue, specific populations of myofibroblasts could be identified that were responsible for driving the disease initiation and progression not previously identified. BLR-200 impaired the ability of collagen-expressing fibroblasts to respond to bleomycin-induced inflammatory-driven fibrosis, including the creation and expansion of critical sub populations. BLR-200 prevented overexpression of pro-inflammatory genes including Il6, Cxcl2, and NLRP3 inflammasome markers and activation of epithelial cell markers and the Wnt pathway in these populations. CCN proteins play an important role in dermal fibrosis, and other forms of fibrosis including cancer.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-? in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-? in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.

Abstract: Provided herein are methods for analyzing polypeptides and polypeptide complexes. Methods of the present disclosure may be used to identify protein subunits present in a polypeptide, polypeptide complex, or aggregate. These methods may also be used to quantify the subunits (e.g. number of repeating units, protein monomers, repeating domains) in a polypeptide, polypeptide complex, or aggregate.

Abstract: The present invention relates to a phosphatidylserine (PS) binding agents comprising one or more C-domains of a milk fat globule-EGF factor 8 (MFG-E8) protein, and methods of making and using the same.

Abstract: The purpose of the present invention is to provide a method for determining the fraction unbound (fu) of compounds including compounds having a high protein binding ratio with accuracy and in a short time.

Abstract: A diagnostic and treatment assembly, configured to diagnose and treat cellular disease. The diagnostic and treatment assembly has a radio wave generator communicatively coupled to a carrier modulator and a radio wave amplifier. An impedance matching system is electrically coupled to the radio wave amplifier. A reflected wave sensor is electrically coupled to the impedance matching system. A radiator applicator is electrically coupled to the reflected wave sensor. A vector impedance analyzer is electrically coupled to the radio wave amplifier. An information collector data network is electrically coupled to the vector impedance analyzer. A data logger is communicatively coupled to the carrier modulator, the vector impedance analyzer, and the reflected wave sensor. The diagnostic and treatment assembly operates in a low-power mode to diagnose a cellular disease and in a high-power mode to treat the cellular disease.

Abstract: An automatic extraction device and a use method therefor. The automatic extraction device comprises a sample processing apparatus (100), a portal frame (200), a consumable assembly (300), and a pipetting apparatus (400). The sample processing apparatus (100) comprises a uniform mixing mechanism (130) and a magnetic attraction mechanism (140), which are respectively used for performing uniform mixing processing and magnetic attraction processing on a biological sample. The portal frame (200) comprises a base (201) and a moving beam (202) capable of moving relative to the base (201). The sample processing apparatus (100) and the consumable assembly (300) are provided on the base (201). The pipetting apparatus (400) is provided on the moving beam (202) for implementing a pipetting operation between the consumable assembly (300) and the sample processing apparatus (100).

Abstract: An automatic analysis system includes: a plurality of automatic analyzers; a conveyance line connected to the analyzers; and a computer configured to control the conveyance line to distribute a sample to the automatic analyzers. Each of the automatic analyzers includes a first component that is constantly used and a second component that is intermittently used. The computer is configured to compare a usage time of the first component of each automatic analyzer with a set time, select, when the usage time of the first component of any one of the plurality of automatic analyzers exceeds the set time, the automatic analyzer in which the usage time of the first component exceeds the set time as a prioritized device, and control the conveyance line such that a sample used for analysis in the second component is conveyed to the prioritized device in preference to another automatic analyzer.

Abstract: A system and method for automatic closure of sample vessels such as vessels with medical laboratory samples, having a plurality of identically shaped, stackable closure caps with a convex outer face and concave inner face that are stacked in a closure cap stack such that an upper closure cap in the stack bears with its convex outer face on the concave inner face of a lower closure cap lying immediately below in the stack. The system includes a closure gripper for gripping an uppermost closure cap from the stack, for transferring the gripped closure cap to the sample vessel to be closed, and for introducing the gripped closure cap into an opening of the sample vessel in order to tightly close the opening. The closure gripper has a centering piece insertable into a closure cap such that it bears on the concave inner face of the closure cap.

Abstract: An automatic analyzer includes a dispensing mechanism having at least one horizontal drive shaft and one vertical drive shaft for moving the dispensing nozzle, a first mechanism having a stop position at which the dispensing nozzle is stopped, and a control section for positioning the dispensing nozzle with the stop position of the first mechanism. A member is disposed on the first mechanism to indicate predetermined first and second positions of the first mechanism so that the first and the second positions are detected by sensing the member using the dispensing nozzle. Based on the displacement between the first and the second positions indicating the displacement of the relative position between the dispensing mechanism and the first mechanism, the control section calculates a correction value for correcting the displacement of the stop position caused by fluctuation in a relative position between the dispensing mechanism and the first mechanism.

Abstract: An inertial sensor unit includes a first board on which a plurality of inertial sensor modules are mounted, and a second board on which a processing circuit configured to process signals from a plurality of inertial sensor modules is mounted.

Abstract: [Problem] To provide a probe and a probe device that can be easily attached to and detached from circuit boards and make it possible to conduct testing of circuit boards or electronic components in an efficient manner. [Means of Solution] A first clamping piece 20 has first clamping portions 25 at one end located adjacent to the circuit board P that make contact with one surface of a circuit board P; a second clamping piece 30 has a second clamping portion 31 at one end located adjacent to the circuit board P that makes contact with the other surface of the circuit board; the first clamping piece 20 and second clamping piece 30 have operative portions 26, 32 at the other end located on the side distal from the circuit board P for receiving an operating force opposing a biasing force exerted by a biasing member 40.

Abstract: A modular/configurable space transformer system may comprise socketed probes, an upper guide plate, a lower guide plate, and a spacer. A socketed probe may comprise an upper support arm with positioning tabs for insertion into slots in the upper guide plate, as well as a PCB contact point for making a conductive connection with a PCB pad. The socketed probe may additionally comprise a lower support arm with a positioning tab for insertion into a slot in an upper guide plate, as well as a DUT (device under testing) contact point for making a conductive connection with a DUT pad. The spacer may separate the upper guide plate and lower guide plate.

Abstract: A probe head with a cylindrical portion and an oblique truncated portion angled downward toward a high-powered electronic device under testing. The probe head has a proximal end comprising an oblique truncated cone portion angled relative to the longitudinal axis at an input angle and has an analog signal input. The probe head has a digital signal output provided on the distal end of the housing.

Abstract: A probing system includes a device-under-test, a probe device, and a die bonder. The device-under-test includes test patterns. The probe device includes tilt angle sensors. The tilt angle sensors include spikes that protrude from the probe device. The die bonder is operational to mount the device-under-test, mount the probe device facing the device-under-test, compress the probe device and the device-under-test together to causes a subset of the spikes to contact the test patterns, measure a number of connections formed between the tilt angle sensors and the test patterns, determine a first offset angle and a second offset angle between the device-under-test and the probe device based on the number of connections, adjust the spherical positioner in one or more rotational axes in response to the first offset angle and the second offset angle to change a parallelism between the device-under-test and the probe device.

Abstract: An integrated circuit (IC) package includes a partial leadframe including (a) a shunt resistor leadframe element including a pair of shunt resistor contacts and a shunt resistor conductively connected between the pair of shunt resistor contacts and (b) at least one external contact leadframe element separate from the shunt resistor leadframe element, the at least one external contact leadframe element allowing external contact to the IC package. The IC package also a mold encapsulation formed over the shunt resistor leadframe element, wherein the pair of shunt resistor contacts are externally contactable through the mold encapsulation.

Abstract: The present disclosure is directed toward systems and methods for measuring electric current in a multi-wire cable, as well as the apparent and real power associated with an electrical load connected to the cable. A probe comprising an array of small form-factor, high-speed magnetometers is operatively coupled with the cable such that the magnetometers partially surround the cable. Each magnetometer detects the composite magnetic field at its location, and this plurality of measurements is used to generate a magnetic-field map. The contributions of the current flow in each wire are identified by deconvolving the magnetic-field map, enabling their locations to be determined and monitoring of the current and power flow. A sensor included in the probe is used to determine the phase of the applied voltage. The phase difference between the voltage and current is then used to determine the real power dissipation of the load.

Abstract: A winch includes a motor, a gear reduction unit, a tie structure, an external power cable, and a rotatable drum. The motor includes a motor housing with a motor case and a first drum support attached to the motor case. The gear reduction unit is drivingly attached to the motor and has a gear housing including a gear case and a second drum support. The tie structure connects said first and second drum supports. The external power cable having a first end and a second end. The first end of the external power cable is configured to be coupled to an external power source. The second end of the external power cable is coupled to a bus bar. The rotatable drum is drivingly connected to the motor and supported by the first and second drum supports.

Abstract: A schematic diagram of a wideband measurement system for mixed-connected CVT based on an optical voltage sensor is provided. The wideband measurement system comprises a CVT power frequency measurement section and an optical wideband measurement section. In the optical wideband measurement section, a low-voltage capacitor is connected in series between the low-voltage terminal and the ground terminal of the medium-voltage capacitor in the capacitor voltage divider. An optical voltage sensor is connected in parallel across the terminals of the low-voltage capacitor to measure the wideband voltage signal under test. The wideband measurement system for mixed-connected CVT described in the invention enables the CVT to have wideband measurement capabilities while ensuring the accuracy of conventional CVT power frequency measurements.

Abstract: A system for measuring a current intensity of a current flowing through an electrical conductor (10), where the system includes a first component (1), which has the electrical conductor (10), and a second component (2), which is separate from the first component (1) and has an evaluation device (23), and a magnetic field-sensitive sensor element (3) and a connection line (4). The connection line (4) is a light guide. The sensor element (3) is non-releasably connected to the first end of the connection line (4) and/or to the first component (1). In the operating state, the two components 1(, 2) are DC-isolated from one another and are releasably connected to one another by means of the connection line (4) by way of a light-guiding connection, where the power supply to the magnetic field-sensitive sensor element (3) by the second component (2) and/or transmission of sensor data from the magnetic field-sensitive sensor element (3) to the evaluation device (23) is ensured by the light-guiding connection.

Abstract: A current sensor includes: a first and a second input terminal configured to be capable of having a sense resistor connected therebetween; a square wave generation circuit connected to the first and second input terminals and configured to be capable of generating a square-wave signal with an amplitude proportional to the voltage across the sense resistor; and a current sense signal output circuit configured to be capable of outputting based on the square-wave signal a current sense signal corresponding to the current passing through the sense resistor.

Abstract: Systems and methods are provided for monitoring the effects of conductive dust deposits that compromise the ability of a trip unit to accurately detect AC current in a circuit interrupter. When a Rogowski coil is used as a current sensor in the circuit interrupter and the trip unit processes the output of the Rogowski coil using a printed circuit board assembly (PCBA) processing circuit, the DC component of the processing circuit output signal can be analyzed to determine whether any conductive dust has formed unintended electrical pathways on the PCBA and compromised the ability of the PCBA to accurately measure AC current in the circuit interrupter. It can be determined that such unintended electrical pathways have formed when the DC component of the processing circuit output either exceeds a predetermined threshold or has increased by a significant amount after opening of the separable contacts.

Abstract: Faults in the secondary-loop of a trans-inductor voltage regulator (TLVR) are detected. Each power stage of the TLVR is connected to a primary winding of a respective transformer in the TLVR. The secondary windings of the transformers and a compensation inductor form a secondary-loop. A phase controller in the TLVR operates to both drive a first power stage to an ON state and to place a second power stage in an OFF state in a first duration. In the first duration, if the first power stage draws a current less than a maximum threshold and if a voltage at the switching node of the second power stage is negative, the phase controller determines that no faults exist in the series secondary circuit. Otherwise, the phase controller determines that one or more faults exist in the series secondary circuit.

Abstract: A method for detecting a topological structure of a grounding grid under extremely cold condition, includes the following steps: in a substation in an extremely cold area, determining a measuring area S on a ground surface of a grounding grid according to the positions of branches and nodes of the grounding grid in a selected area, acquiring dynamic current values of the branches and nodes through a current sensor based on TMR tunnel magnetoresistance, and then indirectly acquiring the magnetic induction intensity of the measuring area S through conversion; calculating moduli of first to third derivatives of magnetic induction intensities; and determining specific positions and laying depths of the branches of the grounding grid according to peak distances between main lobe peaks and side peaks between strong peaks of the moduli. According to the method, the calculation amount is greatly reduced, and the detection method has strong anti-interference.

Abstract: When implementing a PMU network, creation of synchrophasors is achieved by centralising the determining of phasors and corresponding time-stamps at a location away from the actual measurement locations. Alternatively, or in addition to time-stamping phasors, time-stamping of any received signals and/or measurements derived from those signals is enabled. These signals are received from appropriate sensors distributed along optical fibres such as may be incorporated in modern power cables. Likewise, control signals can be communicated along optical fibres such as may be incorporated in modern power cables, and a number of approaches to ensuring control signals are received by the intended control modules are provided. Either or both the PMU network and control system can be implemented in a power network by exploiting existing optical fibre infrastructure in this way, and control signals can be transmitted dependent on analysis performed on synchrophasors.

Abstract: In one embodiment, a power supply comprises: a conversion circuit that outputs an output voltage at a first end of a cable; a remote voltage sensor measures a load delivered voltage from a second end of the cable; a control logic, wherein the power conversion circuit regulates the output voltage based on a signal from the control logic; a current sensor that measures current flow through the cable; and a resistance measurement circuit that computes a resistance of the cable as a function of the load delivered voltage, the current flow and the output voltage. The control logic regulates the load delivered voltage based on a voltage drop calculated utilizing the resistance. The control logic detects a change in the resistance of the cable based on the load delivered voltage and dynamically updates a value of the resistance for calculating the voltage drop when the change exceeds a tolerance.

Abstract: The present disclosure provides a power control system for motor preheating including a current sensor, a power calculation module, a power error calculation module, a power control module, a current control module and a voltage control module. The current sensor senses a motor current output by the motor. The power calculation module calculates an output power of the motor according to the voltage command and the motor current. The power error calculation module calculates a power error according to a power command and the output power. The power control module outputs a current braking command according to the power error. The current control module calculates a voltage command according to the current braking command and the motor current. The voltage control module outputs a three-phase voltage according to the voltage command, and the motor is operated in a stationary state, and the stator of the motor is preheated.

Abstract: A power-meter includes a digital signal processor (DSP) configured to determine a respective consumed energy within each of a plurality of predetermined contiguous time intervals, a dequantizer, and a pulse generator. The dequantizer is configured to, for each time interval, determine a sum of a remainder and the consumed energy, calculate an integer pulse-count by dividing the sum of the remainder and the consumed energy by a predetermined pulse-quantum, calculate a new remainder by subtracting the product of the integer pulse-count and the pulse-quantum from the sum, and replace the remainder by the new remainder The pulse generator is configured to, for each time interval, generate the integer pulse-count number of pulses of an indicator signal.

Abstract: An integrated circuit includes a power amplifier and a power detector. The power detector has a VDET node and a VREF node. A first filter coupled to the VDET node outputs a signal VDET onto a VDET terminal. A second filter coupled the VREF node outputs a signal VREF onto a VREF terminal. The signals VDET and VREF are generated so that the voltage difference between the two signals varies in proportion to the RF output power magnitude with an accuracy of ±0.1 decibels over a ?45° C. to +85° C. temperature range. An amount of the RF signal as output by the power amplifier is coupled onto the VDET node and is detected by a half-wave rectifying RF detector diode. The diode has a capacitance that increases with temperature, so a temperature compensation circuit that has an admittance that decreases with temperature is coupled in parallel with the detector diode.

Abstract: Systems, methods, and apparatuses for measuring capacitance of a load. An apparatus includes a ground connector, an output connector configured to couple to the load, and a time-varying signal source configured to inject a time-varying voltage signal onto a conduction path between the ground connector and the output connector. A DC power source or amplifier is configured to apply a DC offset to the time-varying voltage signal, and a current monitor is configured to measure time-varying current in the conduction path. A capacitance module is configured to determine the capacitance based upon at least one of the time-varying current, and accuracy of this measurement is improved by arranging an AC shunt across the DC power source or amplifier.

Abstract: The present disclosure provides a test system for testing a device under test, the test system comprising at least one measurement application antenna, and a Reconfigurable Intelligent Surface, RIS, reflector configured to reflect an incoming signal that impinges on the RIS reflector with a predefined impinging angle as reflected signal with a predefined outgoing angle, and a measurement application device coupled to the measurement application antenna and configured to qualify beamforming characteristics of the device under test based on RF signals exchanged between the measurement application device and the device under test via the at least one measurement application antenna and the RIS reflector. Further, the present disclosure provides a respective test method.

Abstract: An electric field sensor may include an atomic vapor cell and a plurality of lasers configured to excite atoms in the vapor cell from a low-energy state to a high-energy state. The sensor may be configured to split signals from the plurality of lasers into multiple polarized signals. The polarized signals may be transmitted through the atomic vapor cell. A subset of the polarized signals may be received by photodetectors after the subset exits the vapor cell. Based on signals from the photodetectors, the electric field sensor may determine an angle of arrival and polarization information about an electric field that is incident upon the atomic vapor cell.