Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: Safety needle device (1) comprising: a hub (10) configured to be connected to a pen-injector, the hub (10) comprising a lateral wall (11) and an upper wall (12); a needle (20) attached to the hub (10), a back-end shield (30) slidable along the longitudinal direction (X-X) within the cavity (13) of the hub (10) and rotatable about the longitudinal direction (X-X), the back-end shield (30) being movable irreversibly from an initial position, before connection of the pen injector to the hub (10), to a locking position, after removal of the pen injector to the hub (10) passing through an intermediate position, an elastic member (40) arranged within the cavity (13) and acting between the upper wall (12) and the back-end shield (30) to urge the back-end shield (30) towards the proximal end (21) of the needle (10) along the longitudinal direction (X-X), a locking arrangement (50) comprising at least a first locking member (60) formed on the back-end shield (30) and at least a second locking member (70), the second l

Abstract: The invention relates to an injection system in which drug delivery data are transmitted from a drug delivery device to a mobile device via a wireless Bluetooth connection and, from there, to a remote server via a network connection. A novel method makes it possible for the drug delivery data to be encrypted on the drug delivery device and to be sent via the Bluetooth transmission channel without pairing being carried out. The drug delivery data are decrypted only on the remote server and assigned to the drug delivery device. This process can be supported by both the mobile device and the drug delivery device observing the Bluetooth transmission channel and estimating how far away the relevant sender of the transmitted data is from the mobile device or drug delivery device.

Abstract: A drug delivery device including a main housing and a drug delivery module is provided. The main housing has an internal space. The drug delivery module is disposed in the internal space so as to be isolated from an external environment. The drug delivery module includes a drug bottle that contains a liquid drug and a driver that is connected to the drug bottle. The driver is configured to push the liquid drug to pass through a drug nebulization structure of the drug bottle such that the liquid drug is nebulized into a nebulized drug.

Abstract: A method for applying a medical treatment solution to a treatment site of a patient, that includes removably attaching a syringe assembly so that the syringe assembly is in communication with a pathway that leads to at least one nozzle; charging the medical treatment solution of the syringe assembly; and expelling the charged medical treatment solution to the treatment site.

Abstract: The present disclosure relates to a fluid dispensing device (10) comprising: a housing (11) sized to accommodate a container (20) filled with a liquid substance (21), the container (20) comprising a cavity (22) confined by a shell (23), the shell (23) comprising at least a flexible shell portion (24); a discharge assembly (30) comprising a first member (40) and a second member (50), the first member (40) comprising a hollow tubular section (41) in flow communication with the cavity (22); and the first member (40) and the second member (50) being movable relative to each other along a first direction to discharge a dose of the liquid substance (21) from the cavity (22).

Abstract: An inhaler for inhaling an aerosol may include a container configured to store a liquid, an evaporator device, and a controller. The evaporator device may include (i) an electric evaporator configured to evaporate the liquid to produce the aerosol and (ii) a receiving structure having a predetermined total volume for receiving the liquid. The inhaler may be adjustable to a filling state and to an evaporation state. In the filling state, the receiving structure and the container may be fluidically connected such that the liquid stored in the container is flowable into the receiving structure. In the evaporation state, the receiving structure and the container may be fluidically separated such that the liquid is not flowable from the container into the receiving structure. The controller may be configured to electrically supply the evaporator in the evaporation state such that the liquid received in the receiving structure evaporates.

Abstract: An inhaler article holder is configured to induce swirling inhalation airflow to an inhaler article. The holder is configured to cooperate with the inhaler article to deliver a high dose of dry powder to the user over a limited number of inhalation. The holder and an inhaler article may form an inhaler system to which this disclosure is also directed.

Abstract: Inhalation actuator (6), having a receptacle (5) for receiving a discharge pipe (4) of an inhalant reservoir (1), an inhalant nozzle (9) for spraying inhalant from at least one nozzle outlet opening, an inhalant delivery system (8) for delivering inhalant from the discharge pipe to the inhalant nozzle, a baffle element (10) onto which inhalant can be sprayed in a straight line from the nozzle outlet opening, an aerosol chamber (12) with an internal volume to which inhalant sprayed from the inhalant nozzle can be delivered, wherein the aerosol chamber has an aerosol outlet (11), which has a local narrowing, for dispensing aerosol from the aerosol chamber, and an air delivery system (13) separate from the inhalant nozzle and from the aerosol outlet. Inhalation device having the inhalant reservoir with a pressurized container (2), and having the inhalation actuator, wherein the inhalation actuator does not need to have the local narrowing.

Abstract: Device having a reservoir containing a dose of powder, a head having an orifice, an actuating member displaceable with respect to the head, and an air vent generating a flow of compressed air for delivering the dose of powder into the nostril through the orifice. The air vent has a chamber, formed by a cylinder, and a piston which slides sealingly within the cylinder in order to compress the air contained in the chamber. The device has an insert forming the piston and interacting sealingly, in a rest position, with the reservoir, the insert being axially displaceable with respect to the reservoir between its rest position and an actuation position, in which it no longer interacts sealingly with the reservoir.

Abstract: A portable display unit 3000, 3500, 4000 for a breathing assistance apparatus, the portable display unit comprising: a display unit housing 3001, 3501, 4000; a screen 3051, 3551, 4051; and a tethering component for tethering the portable display unit 3000, 3500, 4000 with abase unit 50 of the breathing assistance apparatus.

Abstract: A blower includes a rotor, a motor adapted to drive the rotor, at least one bearing to rotatably support the rotor, a stationary component, and a bearing sleeve provided to the stationary component. The bearing sleeve is structured and arranged to support and retain the bearing to the stationary component. The bearing sleeve comprises an elastomeric material. The bearing sleeve is structured and arranged to provide a pre-load force to the bearing.

Abstract: An anaesthetic gas capture rig (10) for extracting anaesthetic gas from an anaesthesia machine is provided. The rig comprises or can be connected to suction means for drawing gas exhausted from a machine to the rig. The rig is pneumatically decoupled from the machine so that the rig cannot apply vacuum pressure to the machine.

Abstract: Disclosed are a cardiogenic interference identification method for a medical ventilation device, and a medical ventilation device. The method includes acquiring a first signal and a second signal obtained by a medical ventilation device monitoring a ventilation object, the first signal including a flow velocity signal; according to the flow velocity signal and the second signal, identifying a fluctuation in the flow velocity signal; acquiring a fluctuation characteristic of the fluctuation and, on the basis of the fluctuation characteristic of the fluctuation, identifying cardiogenic interference in the fluctuation. The present method identifies cardiogenic interference on the basis of a signal collected by the medical ventilation device itself, and a physiological signal from an external device is not required. The method has a significant value for clinical.

Abstract: A device for administering oxygen therapy to a patient comprises a gas intake valve; a primary flow path connecting the gas intake valve to a gas output connector, the primary flow path comprising a flow controller configured to adjust a first flow rate through the primary flow path, wherein the flow controller is in electronic communication with a processor and memory; at least one physiological sensor communicatively coupled to the processor performing a method comprising: receiving a target oxygen saturation level; receiving at least one measured physiological parameter from the at least one physiological sensor; analyzing the at least one measured physiological parameter to determine a predicted oxygen saturation level of a patient for a first time window; and adjusting the first flow rate with the flow controller to bring the predicted oxygen saturation level within a threshold value of the target oxygen saturation level.

Abstract: An endotracheal tube device is described herein. The device includes a tubular body having a proximal end and a distal end opposite the proximal end, the distal end having an opening for ventilation, and a distal tip. The device further includes a cuff disposed around the tubular body and configured to be inflated to seal the cuff against a wall of a trachea, the cuff being pear-shaped and having a tapered proximal end and a distal end opposite the proximal end. The device further includes a plurality of markings disposed on an outer surface of the tubular body. This configuration allow the device to be placed in the trachea such that the cuff is positioned below the cricoid of the trachea and prevents the chance of pressure injury if the cuff is positioned in the cricoid.

Abstract: Systems, methods, and devices are disclosed for accurately detecting a position of an endotracheal tube by sensing patient anatomy surrounding the endotracheal tube. Systems of the present disclosure include an endotracheal tube having at two or more sensors supported by the endotracheal tube configured to detect surrounding patient anatomy. A signal processing unit can receive data from the sensor and can at least one of (i) identify the detected patient anatomy, for example, vocal cords, (ii) determine a distance between the detected patient anatomy and a known point on the endotracheal tube, and (iii) verify a positioning of the endotracheal tube within a tracheal or esophageal lumen of the patient. In some embodiments, the system can include at least one inflatable component that can extend along an outer surface of the endotracheal tube and support the at least one sensor.

Abstract: This invention relates to a vent structure for a respiratory therapy system. In one form the vent structure comprises a vent housing. The vent housing may define a flow path for a flow of air being vented from the respiratory therapy system, a vent inlet configured to allow the flow of air to enter the flow path, and a vent outlet configured to allow the flow of air to exit the flow path into the surrounding ambient air. The vent housing may be configured so that the flow path comprises a curved turning region in which the flow path changes direction by at least 90°. The vent housing may comprise an inner path surface on an inner side of the flow path and an outer path surface on an outer side of the flow path. The width of the flow path at the turning region and at a region downstream of the turning region may be at least substantially 0.85 mm.

Abstract: The present invention discloses a functional powder delivery device for precise locating and quantifying when delivering the functional powder to a site in need in a patient. Meanwhile, the device avoids negative pressure effect in the output catheter when airflow is switched, and thus prevents pollution or jam in the output catheter due to splash or back flow of body fluid. The device ensures tube clearance of the output catheter by maintaining continuous airflow, and a special design of airflow switch allows switching to airflow of large volume to carry the powder when required. Through continuous positive airflow in the tube system, the functional powder can be delivered to the site in need by a continuous powder flow, which overcomes drawbacks of the delivery devices in prior arts. In addition, the design of foot pedal can help endoscopist for a solo operation. The serial connecting parts can adapt for various size of bottles of various types of functional powder.

Abstract: A patient interface apparatus and a ventilation treatment device are disclosed. The patient interface apparatus for the ventilation treatment device comprises a main body and a first moisture-extraction part, a gas cavity is defined inside the main body, the gas cavity is configured to communicate with the patient's mouth and/or nose, the first moisture-extraction part is disposed on the main body and includes a first part communicating with the gas cavity and a second part located outside the main body, the first moisture-extraction part is disposed to be capable to absorb moisture inside of the gas cavity and conduct the moisture to the second part through the first part.

Abstract: Headgear, comprising at least one strap; and at least one rigidizer, the headgear being arranged to position one of the at least one strap and one of the at least one rigidizer, with regard to one another such that the rigidizer imparts a desired shape to at least a portion of the strap while allowing said portion of the strap to move relative to the rigidizer.

Abstract: Described is a respiratory humidifying device comprising: a moisture exchanger positioned in a respiratory system having an inspiration and expiration respiratory cycle, the moisture exchanger positioned such that airflow occurring in the inspiration and expiration respiratory cycle is in contact with the moisture exchanger, the moisture exchanger being temperature-responsive and having a critical solution temperature; a heater; and a controller controlling a supply of power to the heater such that: the heater causes the moisture exchanger temperature to rise to or above a first target temperature by about a first target point in the respiratory cycle; and the moisture exchanger temperature falls to or is below a second target temperature by about a second target point in the respiratory cycle, wherein the first target temperature is above the second target temperature, and wherein during inspiration moisture is added to the incoming air and during expiration the moisture exchanger extracts moisture from the

Abstract: An evaporator device for evaporating a substance may include an evaporator, two electrical connections, a blocking conductor, and an electrical current path for an electrical supply of the evaporator. The evaporator may include an electrically conductive evaporator ceramic with a receiving structure that receives the substance during operation. The electrical current path may extend through the two electrical connections, the evaporator ceramic, and the blocking conductor. The evaporator ceramic may be configured to homogeneously provide heat in a thermal operating range between an operation starting temperature and an operation end temperature. The blocking conductor may be heat-transmittingly connected to the evaporator ceramic. The blocking conductor may configured such that, upon exceeding the operation end temperature, an electrical resistance of the at least one blocking conductor abruptly increases.

Abstract: Breathable medical circuit components and materials and methods for forming these components incorporate breathable foamed materials that are permeable to water vapor and substantially impermeable to liquid water and the bulk flow of gases. The materials and methods can be incorporated into a variety of components, including tubes, Y-connectors, catheter mounts, and patient interfaces and are suitable for use in a variety of medical circuits, including insufflation, anesthesia, and breathing circuits.

Abstract: The present application discloses a sealing valve (10), including a guiding tube (1), comprising a first end (11) configured to be inserted into an outer packaging bottle and a second end configured to be connected to an anesthesia vaporizer (12); the outer peripheral surface of the first end (11) is provided with a convex ring (111) protruding toward the inner wall of the outer packaging bottle and abutting against the inner wall of the outer packaging bottle; and a pushing rod (2) configured to be arranged in the guiding tube (1) and slidable along an axial direction of the guiding tube (1) to connect the anesthesia vaporizer with the outer packaging bottle or to block between the anesthesia vaporizer and the outer packaging bottle.

Abstract: The present invention provides systems, methods, and articles for stress reduction and sleep promotion. A stress reduction and sleep promotion system includes at least one remote device, at least one body sensor, and at least one remote server. In other embodiments, the stress reduction and sleep promotion system includes machine learning.

Abstract: A method for manufacturing a catheter in which a catheter body is formed by fusing a first member and a second member. The method includes irradiating an adjacent portion between the first member and the second member with a laser beam in a close state and in an external force application state to fuse the adjacent portion. In the close state, an elastically deformable elastic body having laser transmission property and having a hollow portion through which the first member and the second member are insertable with a gap at no load is brought into contact with the first member and the second member in the hollow portion due to elastic deformation to bring the first member and the second member close to each other.

Abstract: A method of manufacturing an elongate shaft for delivery of a medical device may include disposing a polymeric sheath having a lumen extending therethrough over a mandrel; sliding a proximal portion of the polymeric sheath into a lumen of a metallic tubular member; placing a polymeric tubular member over the distal portion of the polymeric sheath and a distal portion of the metallic tubular member; fixedly attaching a proximal coupler to a distal end of a longitudinal support filament; inserting a proximal end of the longitudinal support filament between the polymeric sheath and the polymeric tubular member to position the longitudinal support filament alongside the distal portion of the metallic tubular member and a distal portion of the polymeric sheath; and reflowing the polymeric tubular member to secure the longitudinal support filament relative to the polymeric sheath and the metallic tubular member.

Abstract: A catheter includes: a catheter body wall having an elongated tubular shape; and at least one wire provided in the catheter body wall, the at least one wire having at least one groove.

Abstract: Systems and methods used to treat a vessel are disclosed. The systems include an occlusion catheter device having a balloon disposed at a distal end and a connector coupled to a proximal end of the catheter. A handle having a slide actuator is coupled to the connector. A seal wire is displaceable by the slide actuator to allow deflation of the balloon through a vent port. The system includes a catheter infusion device that is coaxially disposed over the occlusion catheter device and having a balloon disposed at a distal end and a connector coupled to a proximal end. A backflow prevention member is coupled to the connector and is configured to seal around the occlusion catheter device.

Abstract: The present disclosure relates generally to systems, devices, and methods for supporting, stabilizing, and/or positioning a medical device, such as a transcatheter medical device. The stabilizer allows for control of degrees of freedom from no movement to free movement to selective movements, to substantially translation only movement and/or to substantially rotational only movement of the medical device. The patent describes pure mechanical embodiment as well as smart embodiments that can synergistically sense, actuate and/or transmit data between the stabilizer, medical device and control or display system to operate and/or deploy the device/therapy.

Abstract: A navigation tool assembly has a delivery wire having a distal end and a proximal end, a grip connected to the proximal end of the delivery wire, and a guide sleeve having a tapered distal end and a proximal end that is attached to the distal end of the delivery wire, the guide sleeve having a slit that extends from the proximal end of the guide sleeve to the distal end of the guide sleeve. The guide sleeve is used with an outer catheter having a shaft with a lumen extending therethrough, and either a guidewire or a microcatheter extending through the lumen. The guide sleeve is wrapped around the guidewire or the microcatheter and is retained inside the lumen at the distal end of the shaft of the outer catheter.

Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen in which waste fluid flows proximally therethrough during operation of the catheter pump. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate, the rotor including a longitudinal rotor lumen therethrough. The motor assembly can also comprise a stator assembly disposed about the rotor. During operation of the catheter pump, the waste fluid flows from the lumen into the chamber such that at least a portion of the waste fluid flows proximally through the longitudinal rotor lumen.

Abstract: A tissue treatment catheter includes a catheter shaft having a fluid lumen in fluid communication with an interior of a balloon, and a guidewire lumen. The balloon is mounted on the catheter shaft and contains an ultrasound transducer. An isolation tube extends through the ultrasound transducer and into the guidewire lumen. A proximal tube end of the isolation tube is between a distal shaft end of the catheter shaft and a guidewire port of the catheter shaft. Other embodiments are also described and claimed.

Abstract: The invention relates to a wire device (100), in particular a wire device for insertion in a body lumen, comprising a stiffening portion with a pressure tube (2), a stiffening layer (3) and an outer tube (4). The stiffening layer is arranged concentrically about the pressure tube, and the outer tube is arranged concentrically outside of the stiffening layer. The outer tube is radially stiff and the stiffening layer is radially movable. Pressure can be built up inside the pressure tube such that the stiffening layer can be forced against the outer tube from the inside and the stiffening portion can be reversibly stiffened under pressure. The pressure in the pressure tube can in particular be reduced so that the stiffening portion becomes flexible again.

Abstract: An insertion system includes a main body and a side port mounted at an angle relative to the main body. The side port is sized to receive a guide wire. The insertion system also includes one or more wire guides mounted to the main body and aligned with the side port. The insertion system further includes a handle mounted to the main body.

Abstract: A catheter system may include a catheter assembly and a needle assembly. The catheter assembly may include a catheter adapter, which may include a distal end, a proximal end, a lumen, and a side port. The catheter assembly may include a catheter extending from the distal end of the catheter adapter and an extension tube. A distal end of the extension tube may be integrated with the side port of the catheter adapter. The needle assembly may include a needle safety element, which may be disposed within the safety housing or the catheter adapter. The needle assembly may include a guidewire advancement device coupled to the safety housing or the catheter adapter, and an introducer needle having a proximal end coupled to the guidewire advancement device.

Abstract: Disclosed herein are a catheter assembly and method of applying a catheter assembly. In an example, the catheter assembly can include a catheter body and frame member extending between proximal and distal portions, the frame member having a first mechanical characteristic, and a floating sleeve coupled around the frame member and extending between the proximal and distal portions, the floating sleeve having a second mechanical characteristic different than the first mechanical characteristic. The floating sleeve can include at least one floating segment and one or more anchor segments along the catheter body. The at least one floating segment of the floating sleeve can be moveable relative to the frame member, and the one or more anchor segments of the floating sleeve can be interconnected with the frame member.

Abstract: Devices and methods for providing an internal balloon sheath are disclosed. One device includes a sheath for insertion through an arteriotomy of a patient. The sheath comprises a tubular sheath body having a longitudinal axis, an open proximal end, an open distal end, an outer surface and an inner surface, the inner surface defining a lumen between the proximal and distal ends for passage of a catheter device. The sheath also comprises an inflatable balloon disposed within the lumen. The inflatable balloon is configured to occupy a longitudinal space in the lumen between the inner surface of the sheath body and the catheter device when the catheter device is disposed within the sheath and the balloon is inflated, and fluidically seal the lumen.

Abstract: Devices and methods used to selectively occlude a blood vessel are disclosed. The devices include a catheter having a balloon disposed at a distal end and a connector coupled to a proximal end of the catheter. A handle is coupled to the connector. A slide actuator is disposed within the handle. A seal wire is coupled to the slide actuator. When the slide actuator is in a distal position, the seal wire seals a vent port distal of the balloon to prevent inflation fluid from flowing from the balloon. When the slide actuator is in a proximal position, the seal wire is displaced proximally to unseal the vent port and allow fluid to flow from the balloon and distally out of the vent port resulting in self-deflation of the balloon.

Abstract: One embodiment provides a balloon dilatation catheter. The balloon dilation catheter, according to the embodiment, comprises a catheter tube provided to be disposed in a blood vessel, a balloon connected to the catheter tube and dilatated by fluid injection, a guide tube disposed along the catheter tube in the balloon and one or more bypass tubes located inside the balloon.

Abstract: The present disclosure provides microscale devices, systems, and methods thereof for the delivery of therapeutic and prophylactic active agents (e.g., macromolecules).

Abstract: There currently exists no needle capable of delivering pharmaceutical or cosmetic ingredient(s) into deep layers of integumental tissue (e.g. skin, scales, bark), nor any needle device designed to facilitate the precise administration of a desired dose, and to limit inflammation, pain, and other side effects associated with the needle(s). The present invention relates to an integumental dissolving needle—which houses micronized cosmetic/pharmaceutical ingredient(s), encapsulated by a coating agent absorbed into the integument—arranged on the surface or surfaces of a poultice. Needle thickness and length may be varied according to the biological species of interest. In addition, dosage(s) is/are printed on each section of the device to make explicit how many milligrams of the ingredient are present per unit area; these sections may be separated from one another along groove(s) or other markers on the device. The present invention is a needle device consisting of the above components.

Abstract: Therapeutic agent releasing microneedle arrays are described herein that comprise a hydrogel base supporting an array of microneedles formed from a hydrogel comprising a polymer and one or more therapeutic material releasing agents. The microneedle array can be formed by preparing a solution of a polymer, an oxygen releasing agent, and a nitric oxide releasing agent; applying the solution to a mold in which microneedle cavities are defined; applying a hydrogel base over the solution in the microneedle cavities, which can be of the same type of polymer as in the mold cavities however either with or without one or more therapeutic agents; centrifuging the mold with the hydrogel base; crosslinking and/or curing the microneedles array with the base; and detaching the microneedle array with the hydrogel base from the mold. This method yields an array of microneedles comprising the polymer, the oxygen releasing agent, and the nitric oxide releasing agent.

Abstract: Described is a microneedle device, preferably a controlled release device, for delivery of liothyronine (LT3 or salt thereof) to a patient with hypothyroidism and/or who is not pregnant. The microneedle device contains LT3 or salt thereof in an effective amount to maintain normal, stable levels, in the serum, of free and/or total T3. The microneedle device includes at least two components: multi-dimensional array of microneedle(s) and a substrate to which the base of the microneedle(s) are secured or integrated. The microneedles contain LT3 or salt thereof as well as a biodegradable and/or biodissolvable polymer, such as polyvinyl pyrrolidone for controlled release of LT3 or salt thereof. Also described are methods of making and using the microneedle device.

Abstract: Methods of tattooing and tattoo inking systems comprising a housing, an ink reservoir, a pump and a tattoo cartridge. According to a further embodiment the tattoo inking system comprises a system of channels and valves that allow the artist to provide ink to the tattoo cartridge while working and without dipping.

Abstract: A medical device comprising an implantable subcutaneous access port having a septum penetrable by a needle; the septum having a cavity located between an outer wall and an inner wall, the cavity containing a flowable media comprising a plurality of displaceable particles arranged to move in response to the needle being inserted through the outer wall and into the cavity and reposition around the needle.

Abstract: A coupler may include a coupler body including a first end, a second end, an outer surface, an inner surface defining a cavity, and a wall defined between the inner and outer surfaces, a plurality of first retaining fingers disposed adjacent to the first end and extending radially inward into the cavity, and a mounting aperture defined between a free end of each first retaining finger and the wall. The cavity may be configured to receive a first connector and a second connector. The plurality of first retaining fingers may be radially biased inward toward the cavity and configured to engage against a collar of the first connector to prevent axial motion of the first connector relative to the coupler. The mounting aperture may be configured to receive a pivot shaft of the collar to pivotally couple the first connector relative to a central axis of the coupler body.

Abstract: An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and/or outside a patient's body in, on, and surrounding a tubular structure such as a tube, catheter, and/or a catheter extension to prevent, reduce, and/or eliminate infectious agents in, on, or surrounding the tubular structure. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable, introduced and positioned by an introducer assembly, makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

Abstract: A connector assembly includes an inner connector having a first end, a second end, a sidewall extending between the first end and the second end, and a flange connected to or extending radially outward from the sidewall. The connector assembly also includes an outer connector configured to be inserted over the inner connector having a first end, a second end, a sidewall extending therebetween, and a lock extending radially inwardly from an inner surface of the sidewall configured to engage the flange of the inner connector, thereby securing the inner connector to the outer connector.