Abstract: Provided is a contrast-sensitivity test device that is smaller than conventional ones and that enables a desired illumination environment to be easily set and enables a contrast sensitivity test to be conducted easily and accurately. The contrast-sensitivity test device includes: an illumination unit that emits illumination light such that a field of view of a subject is in a specified illumination environment; a visual target presentation unit that is located within the field of view of the subject and that switches and sequentially presents a plurality of visual targets having different contrasts; a response-time measurement unit that, when the illumination light is emitted, measures a response time after each visual target is presented until the subject recognizes the visual target; and a casing that houses the illumination unit, the visual target presentation unit, and the response-time measurement unit.

Abstract: The present invention relates to a system for measurement of peripheral aberration of the human eye. The system is characterized by a specially designed multifaced mirror having its each face distributed along an elliptical contour. The normal to any point on the elliptical contour bisects an angle formed by the point and the line connecting the two focal points of the elliptical contour. The length of the multifaced mirror is equal to the length of a line segment formed between the intersections of a plurality of tangents drawn at each intersection of the elliptical contour and a plurality of rays. The plurality of rays extends from a focal point at the centre of the entrance pupil to a plurality of other focal points at the centre of the entrance pupil. Each ray has a predetermined difference in gradient with respect to each other adjacent ray.

Abstract: The present invention proposes a technology that enables in vivo imaging while expanding the penetration depth of light into the tissue in an ultrasound-induced optical clearing microscopy (USOCM) system using an optical microscope, in particular, a non-linear optical microscope such as a two-photon microscope, and an ultrasonic transducer. For maximum efficiency, the ultrasonic transducer should be positioned between an optical microscope (objective lens) and the sample. In this case, since an existing ultrasonic transducer is opaque, a laser beam of an optical microscope using an ultrashort laser system cannot pass through the existing ultrasonic transducer. In order to solve such a problem, a transparent ultrasonic transducer is applied such that there is no problem in a laser beam passing therethrough and reaching a sample.

Abstract: The invention relates to a communication adapter and a computer implemented method for use with an implantable medical device, in particular a pacemaker, a defibrillator and/or a neuro-stimulator, for transferring data between the implantable medical device and a mobile device, in particular a smartphone or tablet computer. In addition, the invention relates to protective case and a communication adapter system comprising the communication adapter.

Abstract: Disclosed are a compatible system and a compatible method for synchronize working of magnetic resonance imaging and focused ultrasound thermal ablation. The compatible system for synchronize working includes a magnetic resonance device and a focused ultrasound device, further includes a signal collector and a control circuit connected to the signal collector. In an imaging process of the magnetic resonance device, the signal collector is configured to detect a radio frequency (RF) signal of the magnetic resonance device, and the control circuit is configured for recording a trigger time of the RF signal, generating an enable signal triggering the focused ultrasound device to start heating based on the trigger time of the RF signal, and controlling a heating duration of the focused ultrasound device according to an echo time.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: Embodiments of the present disclosure include a photodiode that can detect optical radiation at a broad range of wavelengths. The photodiode can be used as a detector of a non-invasive sensor, which can be used for measuring physiological parameters of a monitored patient. The photodiode can be part of an integrated semiconductor structure that generates a detector signal responsive to optical radiation at both visible and infrared wavelengths incident on the photodiode. The photodiode can include a layer that forms part of an external surface of the photodiode, which is disposed to receive the optical radiation incident on the photodiode and pass the optical radiation to one or more other layers of the photodiode.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: Systems and methods include a computer-implemented method for determining a diagnosis based on audio-visual information from a monitored person. A subject is monitored using one or more video systems. Vital health information of the subject is determined based at least on the monitoring. At least one diagnosis of the subject is determined based at least on the determined vital health information.

Abstract: This inspection device includes: a detection element for obtaining information on an oral tissue or deposits to be inspected; a case body that includes an information transmission line for transmitting information to the detection element; and an inspection auxiliary member that has a path or a guide through which the detection element or the information transmission line can move and is shaped to follow a tooth row.

Abstract: The invention relates to a device for non-invasive monitoring of at least one compound in blood, comprising a radiation source configured to emit infrared radiation towards a body part, a Fabry-Pérot interferometer configured to modulate the infrared radiation, a thermal detector and a microphone configured to detect reflected infrared irradiation or photoacoustic emission. The device further comprises a processing unit to time-modulate the infrared emission and configured to determine an amount of the compound in blood based on the detected infrared irradiation and/or on photoacoustic emission; and/or a transmitter configured to transmit information on the detected infrared irradiation and/or photoacoustic emission to an external device for processing.

Abstract: A body temperature estimation device includes a measurement unit that measures a temperature of an eye of an animal, and a body temperature estimation unit that estimates a core body temperature of the animal by setting the temperature measured by the measurement unit in a body temperature estimation model and simulating heat conduction.

Abstract: A photoelectric volume pulse wave sensor includes a light-emitting element and a light-receiving element. Electrodes constituting the light-emitting element or the light-receiving element are surface electrodes. At least one electrode among the electrodes is also used as an electrode that detects body motion.

Abstract: The invention relates to a portable device which is designed to be carried on the body of a child, said child being a baby or a small child. The device includes one or more sensors for detecting multiple vital parameters of the child, wherein the vital parameters at least include the heart rate, oxygen saturation, and respiratory rate; analysis software which is configured so as to predict at least one current or future physiological state of the child as a function of the heart rate, oxygen saturation, and respiratory rate measured by the sensors; and an interface for transmitting the prediction result relating to the at least one physiological state to a mobile telecommunication device of a user and/or to a server computer system.

Abstract: A fever detection device includes a heart rate measurement unit configured to measure a heart rate of a target subject; an acceleration measurement unit configured to measure an acceleration of the target subject; an exercise intensity calculation unit configured to calculate exercise intensity of the target subject based on the acceleration; and a fever detection unit configured to determine whether the target subject has a fever based on the heart rate and the exercise intensity.

Abstract: A method of monitoring for changes in a health condition using a non-invasive blood pressure measuring device includes obtaining an acoustic signal from a blood vessel using an audio transducer, converting the acoustic signal to a blood pressure measurement, sampling the pressure measurement over a sample frequency, determining average pressure from the sampled pressure measurement over a target time period, monitoring the average pressure for deviation from a threshold pressure range, and generating an alert signal from the blood pressure measuring device if a deviation from the threshold pressure range is detected.

Abstract: Provided is an optical sensor for monitoring pulse waveform and blood pressure of a subject. The optical sensor may be manufactured with compact structure, low profile, low cost, and exhibits benefits of disposability, easy to apply, immunity to electro-magnetic interference, high sensitivity, having minimal affect towards sense of touch, maintains patient safety, and supportive of accurate real-time measurements for the clinician. Therefore, pulse waveform and blood pressures of a subject may be faithfully monitored continuously throughout day and night, so as to provide abundant prognostic information while avoiding interference in normal daily activity of the subject. Also provided is a system utilizing the optical sensors for monitoring pulse waveform and blood pressure of a subject.

Abstract: The present invention is related to a pulse diagnosis measurement device and related method, the method including the following steps: using a processor to calculate a mean arterial pressure of an organism based on a systolic blood pressure and a diastolic blood pressure of the organism; after applying a pressure onto a pulse location of the organism and adjusting the applied pressure to a first pressure value in a pressure interval using a pulse-holding device, using a sensor to sense a blood pressure wave of the organism in a first time period, so as to generate a first pulse wave signal, wherein the pressure interval is between the diastolic blood pressure and the mean arterial pressure; and using the processor to generate a plurality of first informations of a plurality of harmonics of the blood pressure wave based on the first pulse wave signal in the first time period.

Abstract: A system includes piezoelectric nanofibers, an encapsulation polymer, and patterned electrodes in an array. The array structure of the electrodes can create separate piezoelectric sensor elements, which can detect pressure from pressure such as arterial pulse waves. The sensors arrays can be used to detect the pulse wave velocity of the arterial pulse while it is superficial to near-surface arteries. This can enable detection of blood pressure in a wireless manner.

Abstract: A device for positioning a fetal heart rate transducer against a pregnant women's abdomen. The device includes a body having a lower surface and an upper surface opposite the lower surface. The lower surface is non-planar and includes a protruding portion intended to engage an upper surface of the transducer in use and configured such that the protruding portion can be positioned to apply a force to a selected area on the upper surface of the transducer.

Abstract: Described herein are methods, systems, and software for monitoring blood pressure. In some embodiments, a using a mobile device is used. The blood pressure monitoring system utilizes heart rate measurements at two separate locations on the body to calculate a differential pulse arrival time which is used to estimate blood pressure. The heart rate measurements can be taken simultaneously, or they can be taken sequentially while simultaneously taking ECG measurement. If taken sequentially, the heart rate measurements are aligned with the ECG to determine the differential. Accurate, inexpensive, and discreet blood pressure monitoring is thus provided.

Abstract: A cardiovascular monitoring system includes a first monitoring device configured to couple to a first body part of a subject and a second monitoring device configured to couple to a second body part of the subject. The first monitoring device is configured to measure a first cardiovascular signal and a first motion signal at the first body part, and the second monitoring device is configured to measure a second cardiovascular signal and a second motion signal at the second body part. A controller of the system receives the first and second cardiovascular signals and the first and second motion signals and filters the first and second cardiovascular signals by removing spectral components that correspond to spectral components of the first and second motion signals. Based on a correlated spectral component that is present in both the filtered first and second cardiovascular signals, the system determines cardiovascular information of the subject.

Abstract: A method and a device for diagnostic of skin cancer and other mammalian skin tissue pathologies are described. The method relies on determination of pathological changes in tissue vascularization and capillary blood flow. The device uses photonic emitters and detectors to characterize temporal and spatial changes in blood flow in response to external perturbation such as external mechanical force or temperature change.

Abstract: Disclosed is an electronic device.

Abstract: An optical sensor system for detecting a tissue type in a surgical procedure is described. The optical sensor system includes an excitation source configured to selectively emit excitation light, a probe comprising at least one fiber coupled to the excitation source and configured to illuminate target tissue with excitation light and collect light from target tissue, a compliance member coupled to the at least one fiber, the compliance member being at least partially translucent and configured to deform in response to engagement by a surgical tool, an indicator element configured to emit light in response to receiving an indicator signal, an optical detection module coupled to the at least one fiber and configured to generate a signal based on the collected light, and a controller configured to determine a tissue characteristic based on the signal and generate the indicator signal based on the determined tissue characteristic.

Abstract: Non-invasive systems and methods for quantifying respiratory muscle effort (RME) (or breathing effort, work-of-breathing) are provided. The systems and methods utilize simultaneously measured EMG and accelerometer signals. The measured EMG signal is preprocessed to produce both a signal accentuating regular breathing activity and a signal accentuating sniff activity (deep, sharp inhalations). Time intervals of candidate sniffs are determined from the preprocessed EMG signals. The measured accelerometer signal is preprocessed to produce multiple signals accentuating either upper or lower frequency band activity. Features of the preprocessed EMG and accelerometer signals corresponding to the time intervals of candidate sniffs are analyzed to determine if the candidate sniffs constitute actual sniffs or artifacts. Subsequently, after maximum sniff effort has been identified, RME is quantified by the ratio of the mean of the maxima of regular breathing activity to the value of the maximum sniff effort.

Abstract: The present invention relates to a device, system and method for determining respiratory information of a subject. The device comprises an image input (21) configured to obtain thermal images of the subject, processing unit (22) configured to determine respiratory information of the subject from the thermal images, and an output (23) configured to output the determined respiratory information of the subject.

Abstract: One embodiment relates to a computer implemented method for detecting if a person has fallen in an environment comprising multiple people. The method comprises controlling an active reflected wave detector to measure wave reflections from the multiple people to receive measured wave reflection data that is obtained by the active reflected wave detector. The method further comprises detecting if a person has fallen in the environment using at least a portion of the measured wave reflection data, wherein a fall status of a nearest person in the environment, being a person of the multiple people that is nearest to the active reflected wave detector, is deterministic of a detected fall.

Abstract: Embodiments herein relate to car-wearable devices and systems that can analyze a device wearer's gait and/or provide gait training. In a first aspect, an car-wearable device is included having a control circuit, a motion sensor in electrical communication with the control circuit, a microphone in electrical communication with the control circuit, and an electroacoustic transducer in electrical communication with the control circuit, wherein the car-wearable device is configured to calculate one or more desired gait parameters, and provide a series of audio cues to a device wearer consistent with the one or more desired gait parameters.

Abstract: Technologies for a monitoring system for monitoring a user's movement include a sensor module and a monitoring device. The sensor module is attached to the user or wearable by the user. The monitoring device detects the sensor module positioned in proximity to the monitoring device, receives sensor data from the detected sensor module, analyzes the received sensor data to determine a position and an orientation of the detected sensor module relative to the monitoring device, compares the determined positions of the detected sensor module to predefined planned positions, and initiates an alert notification in response to a determination that a difference between the determined positions of the detected sensor module and the predefined positions is greater than a reference threshold.

Abstract: Presented herein are techniques for monitoring a recipient's cochlea health via a photoplethysmography (PPG) sensor to proactively identify (i.e., predict) changes to the recipient's cochlea health outside of a clinical setting. The cochlea health monitoring techniques presented herein obtain, via either an external or implanted PPG sensor, one or more cardiovascular health biomarkers associated with a recipient's cochlea health, and analyze these biomarkers to predict that a recipient health change is likely to occur.

Abstract: An analyte detection device with circuit board and shell integration is provided. An electronic circuit is arranged on the shell of a transmitter module. The electronic circuit includes at least one electronic component. The electronic component at least includes a transmitter antenna to form a highly integrated analyte detection device embedded between the electronic circuit and the shell of the transmitter module. The electronic circuit occupies less space and meets the miniaturization design requirements of the analyte detection device.

Abstract: Methods and devices include automated coaching for management of glucose states by receiving a user's glucose levels using a continuous glucose monitoring (CGM) device, determining a time in range (TIR) value, determining a TIR state, receiving a glucose variability (GV) value, determining a GV state, determining a starting state based on the TIR state and the GV state, determining that the starting state corresponds to a non-ideal state, generating an optimized pathway to reach an ideal state based on one or more account vectors such as addressing self-management behavior including food, activity, and medication use. The optimized pathway may further be based on computer detection and classification of significant events of interest over time.

Abstract: A non-invasive analyte sensor includes one or more motion sensors and/or one or more temperature sensors. Data from the one or more motion sensors and/or one or more temperature sensors can be used to post-process the data obtained by the non-invasive analyte sensor.

Abstract: Hypoxia-induced deoxy hemoglobin concentration ([dOHb]) may be used as a susceptibility contrast agent in subjects. While the maximal rate of generating blood [dOHb] are limited by constraints in pulmonary gas mixing, decreasing dOHb with reoxygenation of the lungs can be accomplished in one breath, resulting in a step reduction in arterial [dOHb] and thereby a step increase in cerebral BOLD signal recorded with MRI. The BOLD signal changes accompanying a step decrease in [dOHb] can be analyzed to calculate cerebral perfusion measures and compare their maps to those obtained using a bolus of a conventional contrast agent, gadolinium, and a conventional analysis requiring the identification of an arterial input function. The two methods provided comparable anatomically-distributed hemodynamic information.

Abstract: A photometry device can include a first LED to emit light to a target in response to a first current through the first LED, a second LED to emit light to the target in response to a second current through the second LED, and an inductor, coupled to the first and second LEDs, to store energy associated with at least one of the first and second currents.

Abstract: A wireless adapter for a standalone medical device can include a socket housing at a first end of the wireless adapter along a longitudinal axis of the wireless adapter, the socket housing configured to receive and electrically connect with a wireless dongle. The adapter can further include a medical device connector at a second end of the wireless adapter opposite the first end. The medical device connector can electrically connect with a standalone medical device; receive patient data from the standalone medical device; and pass the patient data to the wireless dongle to enable the wireless dongle to wirelessly transmit the patient data to a medical network interface coupled to a patient monitoring hub.

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects.

Abstract: The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges.

Abstract: A device for obtaining a blood sample may include a holder for receiving a sample source, the holder having an actuation portion and a port; a blood collector attachment removably connected to the holder; and a collection container removably connected to the blood collector attachment, the container defining a collection cavity, wherein a collection container detachment member is provided between the blood collector attachment and the collection container to releasably attach the collection container to the blood collector attachment.

Abstract: Disclosed is a system and method for diagnosing a mental disorder and predicting a treatment response on the basis of psychiatric examination data using eye tracking. The method of diagnosing mental disorders and predicting treatment responses performed by the psychiatric examination system includes generating user attention information using user's eye-tracking on a monitor screen on which a test is being performed, receiving an input of psychiatric examination data including the generated user attention information into a learning model for diagnosing mental disorders and predicting treatment responses, and deriving result information related to mental disorder diagnosis and treatment response from the psychiatric examination data including the user attention information by using the learning model for diagnosing mental disorders and predicting treatment responses.

Abstract: An agitation determination apparatus includes an acquisition unit 521 configured to acquire body motion data according to a motion of a body of a target and vital data according to a state of the body of the target, a calculation unit 522 configured to calculate a body motion score serving as an index for determining an agitation state based on the body motion data acquired by the acquisition unit 521 and calculate a vital score serving as an index for determining the agitation state based on the vital data acquired by the acquisition unit 521, and a determination unit 523 configured to determine the agitation state of the target based on the body motion score and the vital score calculated by the calculation unit 522.

Abstract: A method and system for automatically assigning a behavioral category to a subject's study progress corresponding to a particular test with an option to submit multiple versions of a solution. The method is based on abstracting subject solution versions into abstractions that are mapped to previously identified solution abstraction clusters based on some solution abstraction clustering criteria; calculating subject's path through these solution abstraction clusters and identifying a previously identified behavioral cluster to which subject's path is mapped using certain path clustering criteria. As the progress of a subject's solutions through a period of time reflects the evolution of the subject's understanding of the subject, attribution of the subject's path to a behavioral cluster allows for automatic classification of such understanding including identification of abuse or misuse of the educational process.

Abstract: A device, system, and method for assessing and managing mental health of an individual. A device is configured to evaluate data which corresponds to one or more biosignals of the individual, and to detect the intensity of both positive and negative emotional valence in the individual. The individual may have neither positive nor negative emotional valence (e.g., when at rest), only one of positive and negative emotional valence, or some amount of both. If the detected negative emotional valance surpasses a first threshold, the device or system may provide an intervention to the individual to help the individual manage stress and improve mental health. If the detected positive emotional valence surpasses a second threshold, the device or system may record information related to the individual's stress level and provide encouragement to help the individual continue the positive activity.

Abstract: Disclosed herein are devices and methods for dynamically determining the subtype of a medical disorder based on continuous monitoring of biometric data via a portable or wearable electronic device. Also disclosed herein are devices and methods of providing personalized medical care based on the dynamically determined subtype of a medical condition. The subtype can be dynamically updated based on the presentation of new symptoms, whereby the user can be provided with personalized medical care in a timely manner based on the updated subtype.

Abstract: A series of cues are provided to mammalian subject in association with a predetermined pattern of response states. Responsive to each cue, a physical signal of actuation, or non-actuation within a predetermined time from initiation of the cue, is received and recorded in association with the respective response state. Each response state is an active-escape state, a passive-escape state, an active-avoid state, or a passive-avoid state. The predetermined pattern includes a plurality of sequences and at least one reversal. The physical signals are transformed according to a predefined model incorporating the predetermined pattern to obtain at least one learning variable of the mammalian subject that includes at least one of a belief decay rate and a learning rate, and the predefined model is applied to the learning variable(s) to classify an expected cause of an individual bias of the mammalian subject toward or away from active-escape behaviour.

Abstract: The present disclosure provides diagnostic methods for evaluating a urinary bladder and methods of enhancing the visibility of the bladder. An illustrative implementation includes introducing urinary catheter having a proximal end and a distal end into a patient's urinary bladder by way of the urethra, the urinary catheter including an outer tubular member including an inflatable balloon disposed thereon, and a visualization stylet that is slidably disposable within a passage defined in the outer tubular member. The method further includes inflating the inflatable member inside of the bladder, inflating the bladder with a liquid to enhance visualization of an inner surface of the bladder, illuminating a light source through the inflatable member to illuminate the inner surface of the bladder, and visualizing an inner portion of the bladder using the visualization stylet.

Abstract: Urine collection systems and associated methods and devices are disclosed herein. A representative system can include a urine collection device, a flow control assembly configured to direct a urine flow from the patient to the urine collection device, and a urine measurement device including a first sensor and a second sensor. The first sensor is configured to generate first sensor data based on a weight of the container, and the second sensor is configured to generate second sensor data based on the urine flow from the patient to the container. The system can further include non-transitory computer readable media having instructions that, when executed by one or more processors, cause the system to perform operations comprising determining a first patient urine output based on the first sensor data; and determining a second patient urine output based on the second sensor data.

Abstract: The present invention relates to a textile electrode, a textile product comprising a textile electrode and to a method of manufacturing a textile electrode.

Abstract: The present invention is a bio-electrode includes an electro-conductive polymer composite layer, an electro-conductive layer (C), and a substrate (D). The electro-conductive polymer composite layer consists of an electro-conductive polymer composite which includes (A) a ?-conjugated polymer and (B) a dopant polymer. The substrate (D) has a transmittance of 20% or more at a wavelength of 600 nm and is yellow-red (YR) with a value in the range of 1 to 9 and a chroma in the range of 1 to 12 in the Munsell color system. This provides: a bioelectrode which is thin film, highly transparent, slightly different from the skin in color, highly sensitive to biological signals, excellent in biocompatibility, light-weight, manufacturable at low cost, capable of preventing significant reduction in the sensitivity to biological signals when wetted with water or dried and when attached on the skin for a long time; and a method for manufacturing the bio-electrode.