Abstract: Disclosed is an electrode assembly, comprising an electrode configured to be placed on a surface of a subject's body for recording an electric body signal, an electrode receptacle configured to receive the electrode, and a coupling mechanism configured to couple the electrode to the electrode receptacle, the coupling mechanism having a locked configuration, in which the electrode is coupled to the electrode receptacle, and an unlocked configuration, in which the electrode is decoupled from the electrode receptacle. The disclosure also relates to an electrode, an electrode receptacle and a system.

Abstract: Systems and methods are disclosed for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions.

Abstract: A method for presenting cardiac information originating from multiple leads connected to a patient. The method includes receiving the cardiac information collected via the multiple leads and detecting segment within the cardiac information. The method further includes creating a radar chart divided into sectors and plotting data points on the radar chart that correspond to the cardiac information for first and second sets of leads within the multiple leads, where the data points corresponding to the first set of leads are shown differently than the data points corresponding to the second set of leads so as to be visually distinguishable from each other.

Abstract: A method for extracting a fetal electrocardiogram (ECG). comprising determining, via processing circuitry, a coherence between a maternal ECG and an abdominal ECG, attenuating, via the processing circuitry, the maternal ECG independent of the coherence, and extracting, via the processing circuitry, the fetal ECG from the abdominal ECG based on the coherence and the attenuated maternal ECG.

Abstract: Methods and systems for electrophysiological measurement involve obtaining signals that indicate cardiac electrical activity by using electrodes in contact with the body tissues of a living patient. These signals are then processed to identify local activation times at the electrodes. The identified local activation times are displayed as traces representing the signals over time on a display screen. The brightness of specific trace segments within a designated time window, encompassing the identified local activation times, may be increased relative to segments outside the time window. The method provides flexibility in signal acquisition, allowing for the use of intracardiac electrogram signals acquired within the heart or electrocardiogram signals acquired from the body surface. This method enhances visibility and enables efficient analysis of cardiac activity traces for diagnostic and monitoring purposes.

Abstract: A method of processing ECG signals from a plurality of electrocardiogram (“ECG”) leads connected to a patient, applying the ECG signals from the ECG leads to a low-pass filter to obtain a low-band filter (“LBF”) energy values for the lead and to a high-pass filter (“HBF”) to obtain high-band filter energy values for the leads. Running averages of LBF and HBF energy values are utilized to calculate signal-to-noise (“S/N”) ratios for the leads. The S/N ratios are used to select two leads for providing ECG signals to an ECG signal processing algorithm.

Abstract: The present disclosure provides a method and an apparatus for assessing a physiological signal quality based on an IABP device, and relates to the technical field of medical instruments. The method includes: acquiring, in the operation process of an IABP device, physiological signal of a patient treated by the IABP device, where the physiological signal include an electrocardiographic signal and/or an arterial blood pressure signal; extracting signal parameter values of the physiological signal, where the signal parameter values include: a first kurtosis, a skewness, an effective signal ratio, a second kurtosis, and a dominant frequency; performing signal quality assessment on the physiological signal based on the signal parameter values; and implementing, based on the physiological signal, intra-aortic balloon counterpulsation in response to a signal quality assessment result represents that the signal quality of the physiological signal satisfies a preset signal quality requirement.

Abstract: A method to detect noise levels in electrocardiogram (ECG) signals is provided. The method includes connecting to at least three sensing electrodes and obtaining a signal from each of the at least three sensing electrodes. The method also includes defining at least three channels between the at least three electrodes and obtaining heart data for a predetermined time period from the at least three channels wherein the heart data includes heart rate and QRS width. The method further includes comparing the heart data of each of the at least three channels to a consistency threshold.

Abstract: Systems and methods for interpreting a user's brain wave data from EEGs using machine learning algorithms are described. In one example, a brain activity interpretation system classifies the EEG recording into five separate component signals, representing the five categories of brain waves (alpha, beta, theta, delta, gamma). In one example, the most dominant component signal is analyzed to determine whether the amplitude is higher or lower than an optimal range within the bandwidth for that brain wave. The system can then provide intelligent recommendations to the user for beneficial action(s) to help improve their everyday functioning and promote better regulation of their brain states. The system can help the user become more aware of their mental state and how to improve their mental state. EEG data is highly complex and unsuitable for immediate human comprehension, thus, the disclosed systems and methods improve the speed and accuracy of brain wave analysis.

Abstract: A detection function is used to detect an event in an electroencephalogram (EEG) signal in order to generate a plurality of detected events. For each detected event in the plurality of detected events, a plurality of features from the EEG signal is measured in order to obtain a measured feature vector, where the plurality of features is defined by a feature space corresponding to the event and a measured feature space includes a plurality of measured feature vectors corresponding to a plurality of labeled points having locations. The EEG signal is classified based at least in part on the locations of the plurality of labeled points in the measured feature space.

Abstract: Described herein are systems and methods for modifying pain sensitivity in a subject. Example systems can include a plurality of sensors configured to detect electroencephalography (EEG) signals in the subject, and a processor communicably coupled to the plurality of sensors. The processor can be configured to receive first EEG signals from the sensors and determine, based on the first EEG signals, at least one of (i) a first value for a predicted pain sensitivity (PPS) associated with the subject or (ii) a second value for a peak alpha frequency (PAF) associated with the subject. The processor can be further configured to receive second EEG signals from the sensors and provide feedback to the subject when a characteristic of the second EEG-signals indicates a. reduced pain sensitivity.

Abstract: A method for assessing neurological function in a subject includes a) prompting a user to follow a moving saccade-evoking stimulus on a display, b) tracking eye movement of the subject while the user follows the moving stimulus, c) collecting a first eye conjugacy data of the subject relating to the saccade-evoking stimulus, and d) comparing the first eye conjugacy data with a second eye conjugacy data, the second eye conjugacy data relating to an anti-saccade stimulus.

Abstract: A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

Abstract: An automated allergy office system and method provides a medical professional with a new allergy treatment plan to administer to a patient. The automated allergy office system comprises a smart phone or a tablet computer to select a test site on the patient's skin that is clear. A multiple test applicator is in cooperative engagement with a fluid tray and delivers a small amount of a first allergen to a first test site on the patient's skin as a small amount of a second allergen is delivered to a second test site on the patient's skin. The allergy condition of the patient is detected as a wheal forms at the first test site after fifteen minutes. The elements of the treatment plan are retrieved from a database for treating the patient's allergy condition.

Abstract: An automated allergy office system having an augmented reality headset for viewing a target location on a patient, where the target location is to be used for application of an allergen. The augmented reality headset includes artificial intelligence that at least one of visually identifies, grades, records, and displays a message summarizing information within the target location, including at least one of wheal color, wheal flare, skin color, skin discoloration, skin temperature, and location on the patient.

Abstract: Exemplary embodiments of the present disclosure are directed to systems, methods, and devices for determining at least one structure or at least one characteristic of a uterus. Exemplary embodiments of the present disclosure may include a probe, such as an endoscope, that includes a fiber bundle which includes a group of fibers which transmit one or more first electro-magnetic (EM) radiation to at least one portion of a uterus, and another group of fibers which receive one or more second EM radiations exiting the at least one portion which are based on the first EM radiations and a hyperspectral imaging camera obtaining at least one image data associated with the second EM radiations to determine the at least one of the structure or the at least one of the characteristic.

Abstract: A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. Systems for performing these methods with monitored flow rate and independent of patient height relative to the pressure source are also disclosed.

Abstract: Systems and methods can initialize medical devices. The system includes an external programming device configured to: transmit a voltage-based index value through a wired connection to an uninitialized medical device of the plurality of uninitialized medical devices, wherein the voltage-based index value identifies the external programming device; and establish a wireless connection between the external programming device and the uninitialized medical device based on the voltage-based index value.

Abstract: Sleep conditions such as sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: Disclosed herein, in some aspects, are systems and methods for determining and/or monitoring a stool condition for a subject. In some embodiments, the stool condition is based on one or more images of stool of a subject. In some embodiments, the stool condition correlates with a stool assessment comprising i) a characterization of the stool according to a plurality of characteristics, and/or ii) identifying one or more medical conditions, illnesses, and/or diseases associated with the stool. In some embodiments, the stool condition is determined using one or more Artificial Intelligence engines using a trained data set. In some embodiments, the stool condition is based on one or more stool assessments performed for one or more stools corresponding to one or more bowel movements over a period of time.

Abstract: Embodiments of the invention include devices, systems, methods and software applications that automatically detect measured blood alcohol content (BAC). In aspects, a blood alcohol content sensor detects blood alcohol content by measuring an amount of sweat via a wearable device. The systems and methods can also predict the future BAC of a subject by considering the present BAC along with physiological events and/or historical data. The results can be reported to a server to applying a protocol in response to the reported results.

Abstract: A system includes a processor comprising a multivariate predictive model. The multivariate predictive model can be configured to classify responses of a plurality of subjects to a stimulus, predict at least one of a response or an intervention of a target subject to the stimulus based on the classified responses, and adjust a tissue metabolic adequacy of the target subject based on at least one of the predicted response or the predicted intervention of the target subject. The stimulus can include a physical stress, a disease-related stress, a severity of stress, a severity of insult, an external environment condition, or combinations thereof. The tissue metabolic adequacy can be calculated based on a vasomotor tone, a ventricular pump function, an effective circulatory volume, or combinations thereof.

Abstract: An embodiment is a device including a substrate, the substrate being flexible. The device further comprises an electrode configured to be in contact with a living body, a circuit connected to the electrode via an electric wiring, a wireless transceiver connected to the circuit and configured to transmit and receive signals, a power supply configured to supply electric power to the circuit and the wireless transceiver, and a battery connected to the power supply, where the electrode, the circuit, the wireless transceiver, the power supply and the battery are mounted on the substrate, and the substrate is configured to be deformed to make the wireless transceiver arranged away from the living body when attached to the living body.

Abstract: [Problem] An object of the present invention is to provide an attachment fixture that facilitates appropriate mounting of a physical information acquisition device that performs sensing inside a user's body. [Solution] The present invention to solve the above problems is an attachment fixture 1 that can attach a physical information acquisition device 2 that measures physical information of a user by emitting a measurement wave including a millimeter wave or a microwave from an emission and entrance surface 22 toward the user to a belt 3, the attachment fixture including: an attachment fixture body 11 (Q); a mounting portion that can be mounted to a waist part of the user; and an attachment portion 12 to which the physical information acquisition device 2 can be attached.

Abstract: An improved wearable biosensor device having emergent properties such as extended wear life, elimination or significant reduction of warm-up time, a user-friendly insertion process that ensures secure skin-locking immediately post-insertion, enhanced durability of microneedles against breakage, superior user experience and comfort during wear, and improved scalable manufacturability. Together, these innovations not only elevate the sensor's overall performance but also its accuracy, functionality, and reliability. This novel design and functionality guarantees that the wearable biosensor device is more efficient, provides a better experience for users and establishes a new benchmark in the industry.

Abstract: A smart intravenous catheter (IVC) assembly includes a stabilization platform configured to hold an IVC in a fixed position relative to tissue of a patient, and a sensor module mechanically supported by the stabilization platform. The sensor module includes at least one sensor configured to sense a physical characteristic of the tissue of the patient and produce sensed data representing the physical characteristic of tissue of the patient, and a transceiver configured to transmit the sensed data to a smart device remote from the stabilization platform.

Abstract: According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.

Abstract: A user device may machine segment sensor measurements by determining a context window. The context window may include a beginning and an end. The context window may be used to define the time period in which measurements of the sensor measurements are to be segmented.

Abstract: This disclosure is directed to systems and techniques for detecting change in patient health based on a modular machine learning architecture ensembling different cardiac events. In one example, a medical system is configured to: detect a cardiac event type for the patient based on a classification of the patient physiological data in accordance with a modular machine learning architecture, wherein the modular machine learning architecture comprises, for each of a plurality of cardiac event types, an ensemble that comprises a current component model for classifying the cardiac EGM data as evidence of that respective one of the plurality of cardiac event types; and generate for display output data indicative of a positive detection of the cardiac event type.

Abstract: A graphical representation may be displayed including at least a plurality of transducer graphical elements, each transducer graphical element of the plurality of transducer graphical elements representative of a respective transducer of a plurality of transducers of a transducer-based device. A set of user input may be received including an instruction set to reposition a first transducer graphical element in a state in which the first transducer graphical element is located at a first location in the graphical representation and a second transducer graphical element is located at a second location in the graphical representation, the second location closer to a predetermined location in the graphical representation than the first location. In response to conclusion of receipt of the set of user input, the first transducer graphical element may be repositioned from the first location in the graphical representation to the predetermined location in the graphical representation.

Abstract: A personal alarm system including a sound-detecting transmitter and a pressure-detecting receiver capable of generating a local stimulus generated by the receiver and at the receiver's location once a signal indicative of a detected sound is transmitted from the transmitter to the receiver while the receiver is detecting whether or not pressure is present.

Abstract: An electronic medical record (EMR) management system incudes a data server configured to store an EMR of a patient; an imaging device configured to capture an image medically related to the patient and transmit the captured image; and an information management system communicatively coupled to the imaging device and to the data server, where the information management system is configured to receive the captured image from the imaging device, automatically associate the captured image with the patient, and store the captured image in the EMR of the patient in the data server.

Abstract: Using deep learning, imaging harmonization among images produced with differing PET tracers is achieved. A method may include providing an original PET image of the brain using an original PET tracer, providing a target PET tracer, and converting, using a deep learning neural network, the original PET image into a target PET image simulating the image that would be obtained had the target PET tracer been used.

Abstract: An X-ray computer tomographic apparatus according to an embodiment includes a gantry, a bearing, a driver, and a stand. The gantry rotatably supports a rotation unit on which an X-ray tube is mounted. The bearing is connected to the gantry and includes an inner ring with a plurality of teeth on an inner circumferential surface and an outer ring that is connected to an outer circumference of the inner ring via a plurality of rolling elements. The driver causes the inner ring to rotate via the teeth. The driver is mounted on the stand and the stand is connected to the outer ring and is provided on a floor surface.

Abstract: Presented herein are systems and methods that provide for improved computer aided display and analysis of nuclear medicine images. In particular, in certain embodiments, the systems and methods described herein provide improvements to several image processing steps used for automated analysis of bone scan images for assessing cancer status of a patient. For example, improved approaches for image segmentation, hotspot detection, automated classification of hotspots as representing metastases, and computation of risk indices such as bone scan index (BSI) values are provided.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method includes processing acquired projection data of a monitoring area of a subject to measure a contrast signal of a contrast agent delivered to the subject, determining a hemodynamic marker of the subject based on the contrast signal, generating a scan prescription based on the determined hemodynamic marker of the subject, and performing a multi-phase contrast scan according to the scan prescription.

Abstract: Presented herein are systems and methods for predicting biochemical progression free survival (bPFS) in prostate cancer patients. In certain embodiments, bPFS is predicted from 18F-DCFPyL PET/CT images using deep learning (or other machine learning or artificial intelligence techniques) to segment anatomical information from the CT image and use this information in combination with the PET image to detect and quantify candidates for prostate cancer lesions.

Abstract: An intraluminal sensing device may include a flexible elongate member, a housing, and a sensor. The flexible elongate member may include a distal portion and a proximal portion and may be configured to be positioned within a body lumen of a patient. The housing may be positioned at the distal portion of the flexible elongate member. The housing may include a conductive material and a non-conductive material. The sensor may include an exposed conductive surface and may be configured to obtain physiological data while positioned within the body lumen. The sensor may be positioned within the housing such that the exposed conductive surface contacts the non-conductive material of the housing and is electrically isolated from the conductive material.

Abstract: The systems and methods of the present invention facilitate optimized and personalized drug treatment for in vitro fertilization patients. Moreover, the invention allows physicians to make scientific-based decision making. Specifically, the invention reduces drug dosage and testing and helps to get better outcomes.

Abstract: Systems and methods for non-invasively measuring intracranial in accordance with embodiments of the invention are illustrated. One embodiment includes a method for estimating an intracranial pressure of a patient, including introducing a tracer into the blood of a patient, recording, using an imaging device, the traversal of the tracer through a brain of the patient as a kinetic curve, estimating a mean transit time (MTT) of the tracer through the brain of the patient based on the kinetic curve, measuring a mean arterial pressure (MAP) of the patient, calculating an intracranial pressure index as MAP?Ck/MTT, where C is a constant to scale proportional relationships based on healthy patient population characteristics, and k is a constant in pressure/time, and providing the intracranial pressure index. In various embodiments, regions of the brain unaffected by transient vascular abnormalities are identified and are used for data collection.

Abstract: Medical systems are described, including a medical system that includes a sheath and a catheter. The sheath is configured to be positioned within a urethra of a patient. A proximal portion of the sheath includes a port configured to receive one or more fluids. The catheter is insertable into the sheath and configured to be movably positioned within the sheath in the urethra. A distal portion of the catheter includes one or more ultrasound transducers configured to perform ultrasound imaging of at least a portion of a prostate of the patient.

Abstract: An imaging catheter assembly is provided. In one embodiment, the imaging catheter assembly includes a flexible elongate member comprising a distal portion and a proximal portion; a tip member coupled to a distal end of the distal portion of the flexible elongate member, wherein the tip member includes a tubular body comprising a closed distal end, an opened proximal end, and a proximal curved top outer wall extending from the proximal opened end and tapering into a distal flat top outer wall towards the closed distal end; and an imaging component mounted within the tip member. In one embodiment, the imaging catheter assembly includes a flexible elongate member; a tip member coupled to a distal end of the flexible elongate member, wherein the tip member includes a cylindrical body and a uniform outer diameter; and an imaging component mounted within the tip member.

Abstract: A scanning assembly, including: a housing, wherein a lower portion of the housing comprises an opening, and the opening can be closed by tissue to be scanned; a pressure difference generating device, disposed on the housing and used to generate an air pressure difference between the interior and the exterior of the housing, the air pressure difference providing a first pressure for the tissue to be scanned, the weight of the scanning assembly providing a second pressure for the tissue to be scanned, the tissue to be scanned being compressed under the action of a compressive force, and the compressive force comprising the first pressure and the second pressure; and an ultrasonic transducer, disposed in the housing and used to perform ultrasound scanning on the compressed tissue to be scanned.

Abstract: An ultrasound imaging system may analyze acquired images, location and orientation of an ultrasound probe, and usage data to provide suggested annotations for the acquired images. The annotations may have various forms, such as text and bodymarker icons.

Abstract: Various methods and ultrasound imaging systems are provided for segmenting an object. In one example, a method includes accessing a volumetric ultrasound dataset, receiving an identification of a seed point for an object in an image generated based on the volumetric ultrasound dataset, and implementing a two-dimensional segmentation model on a first plurality of parallel slices based on the seed point to generate a first plurality of segmented regions. The method includes implementing the two-dimensional segmentation model on a second plurality of parallel slices based on the seed point to generate a second plurality of segmented regions. The method includes generating a detected region by accumulating the first plurality of segmented regions and the second plurality of segmented regions. The method includes implementing a shape completion model to generate a three-dimensional shape model for the object, and displaying rendering of the object based on the three-dimensional shape model.

Abstract: Disclosed are a shear wave elasticity measurement method and a shear wave elasticity imaging system. For each pair of corresponding shear waves, an echo signal within a continuous period of time can be obtained only at a third position, so that an elasticity parameter corresponding to the target area can be obtained according to the echo signal within the continuous period of time. Not only the position required for obtaining an echo signal is few, but also the total data volume required for obtaining the echo signal is few; the calculation method is also easy, which significantly reduces the system performance requirement.

Abstract: An ultrasound diagnosis apparatus according to an embodiment includes transmitter and receiver circuitry and Doppler processing circuitry. The transmitter and receiver circuitry is configured to transmit ultrasound and receive an echo signal corresponding to the ultrasound. The Doppler processing circuitry is configured to perform principal component analysis of a first signal data string obtained from the echo signal, and is configured to extract a second signal data string from the first signal data string by reducing a predetermined Doppler frequency component, on the basis of at least one of an eigenvalue and an eigenvector obtained by the principal component analysis.

Abstract: A lung injury monitoring system (200) configured to monitor a patient's lungs during ventilation. comprising: an ultrasound device (280) configured to obtain an ultrasound image of the patient's lungs during ventilation of the patient: a processor (220) configured to: (i) receive the obtained ultrasound image: (ii) determine a ventilation phase of the ventilator: (iii) analyze the received ultrasound image: and (iv) determine a risk score for a potential ventilator-associated lung injury (VALI): and a user interface (240) configured to display the determined risk score for the potential VALI.

Abstract: A medical apparatus includes circuitry configured to acquire ultrasonic information, inside a living body, which is obtained from an ultrasonic probe that includes an ultrasonic sensor and applies ultrasonic waves into the living body, generate an ultrasonic echo image representing a longitudinal section of a blood vessel from the ultrasonic information, generate a guide image including a guideline extending along a center line of the blood vessel appearing in the ultrasonic echo image from the ultrasonic information, generate a composite image in which the ultrasonic echo image and the guide image are superimposed.

Abstract: Systems that include an array of ultrasound transducers divided into two or more sub-arrays where for example, a one or two dimensional array, with a long axis in a lateral direction, may be divided in half. The system may include a different beamformer for each sub-array. Each sub-array may define independent and spatially separated sub-apertures. The spatial separation of the two sub-apertures allows for aperture compounding to reduce speckle because the received ultrasound waves at each sub-aperture are propagating in a different direction with respect to each other. This may allow the point spread function for the ultrasound signals corresponding to each sub-aperture to be decorrelated for reducing speckle. The speckle can be reduced by averaging the ultrasound signal from each of the sub-apertures, and a higher resolution can be maintained by also using the signal from the full aperture.