Patents Issued in October 31, 2024
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Publication number: 20240361299Abstract: A replaceable alcohol sensor module for use with a breathalyzer. The alcohol sensor module requiring calibration can be removed from the body of the breathalyzer and replaced with a new alcohol sensor module. The alcohol sensor module has at least an alcohol sensor and a circuitry mounted on a PCB that removable connects the replaceable alcohol sensor module to the breathalyzer. The circuitry transmits the signal and/or electrical current generated by the alcohol sensor to a processing unit of the breathalyzer for processing.Type: ApplicationFiled: July 8, 2024Publication date: October 31, 2024Inventor: MATTHEW HOGYUN SON
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Publication number: 20240361300Abstract: The present invention relates to a biomarker for regulatory T cells.Type: ApplicationFiled: May 10, 2024Publication date: October 31, 2024Inventor: Christina Rae-Kyung LEE
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Publication number: 20240361301Abstract: The present disclosure relates, inter alia, to perturbagens and methods for directing a change in the cell state of an intestinal stem cell and/or a basal cell. It also relates to methods for increasing a quantity of goblet progenitors, goblet cells, Paneth cells, and/or enteroendocrine cells or immediate progenitors thereof and/or the ratios thereof, and methods for decreasing the function and quantity of goblet cells or immediate progenitors thereof. Further, the present disclosure relates to methods for treating diseases or disorders characterized by, at least, abnormal function, abnormal ratios and/or abnormal numbers of goblet progenitors, goblet cells, Paneth cells, and/or enteroendocrine cells, or immediate progenitors thereof.Type: ApplicationFiled: September 9, 2022Publication date: October 31, 2024Inventors: Morag Helen STEWART, Angeliki CHALKIADAKI, Yuge JI, Fabian Alexander WOLF, Nicholas McCartney PLUGIS, Poorya HOSSEINI, Inna LIPCHINA, Sophie Andrea TRITSCHLER
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Publication number: 20240361302Abstract: The embodiments of the present disclosure provide a device for sample collection and a method for sample collection. The device for sample collection comprises a collection part, a detection part, and a connection part configured to connect the collection part and the detection part. The collection part includes a core body. The connection part includes a hollow structure. At least a portion of the core body is disposed in the hollow structure. The core body has hydrophilicity. The device for sample collection is provided with the core body with strong hydrophilicity in the collection part, the core body has a large hydrophilic surface, and the core body absorbs the sample, so that a collected sample volume and efficiency of collection can be improved. In addition, the core body has a maintenance effect on the sample, achieving an unlimited collection angle.Type: ApplicationFiled: July 11, 2024Publication date: October 31, 2024Applicant: ASSURE TECH. (HANGZHOU) CO., LTD.Inventors: Lei YAO, Shisheng LING
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Publication number: 20240361303Abstract: Provided herein are methods, systems and kits for detection of certain placental proteins, such as PAPP-A and ADAM-12, for example, in a serum sample from an individual to classify gestational ages above and below a specific threshold, such as for use in determining for use in determining gestational age for making clinical or personal decisions without ultrasound.Type: ApplicationFiled: July 9, 2024Publication date: October 31, 2024Applicant: Gynuity Health Projects, Inc.Inventors: Laura FRYE, Elizabeth RAYMOND, Beverly WINIKOFF
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Publication number: 20240361304Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.Type: ApplicationFiled: May 7, 2024Publication date: October 31, 2024Applicant: Standard BioTools Canada Inc.Inventors: Vladimir Baranov, Alexander Loboda, Michael Sullivan
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Publication number: 20240361305Abstract: A method of predicting acute mountain sickness (AMS) at sea level, prior to altitude ascent, that identifies level of AMS risk (no, mild, severe). The method includes collecting a urine sample from a subject and analyzing the urine sample for a quantity of at least one metabolite selected from the group consisting of creatine, taurine, N-methylhistidine, hypoxanthine, 1-methylnicotinamide, 4-hydroxyphenylpyruvate, acetylcarnitine, and 3-methylhistidine. The quantity is compared to a threshold value for the respective metabolite. Based on the comparison, it is determined whether the subject will be susceptible to experience AMS, and its severity, once at high altitude.Type: ApplicationFiled: July 9, 2024Publication date: October 31, 2024Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: Camilla A. Mauzy, James P. Karl, Beth A. Beidleman
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Publication number: 20240361306Abstract: Isolated antibody compositions for immunolabeling are described herein. These compositions overcome many of the limitations currently involved with immunolabeling such as low fluorescence and high noise signal.Type: ApplicationFiled: April 26, 2024Publication date: October 31, 2024Inventors: Arron Sullivan, Andrew P. Capaldi, Roderick Capaldi, Nikita Fernandes
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Publication number: 20240361307Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.Type: ApplicationFiled: March 15, 2024Publication date: October 31, 2024Inventors: Omid Farokhzad, Morteza Mahmoudi, Claudia Corbo
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Publication number: 20240361308Abstract: A system and method for detecting, enumerating, or extracting microorganisms in a sample is disclosed. Target microorganisms, such as Salmonella bacteria, may be of interest. Magnetic beads may be bound to the target microorganisms. After which, the bead-bound cells may be isolated. For example, a magnetic field may be applied in order to separate the target cells (with the magnetic beads attached thereto) and move then to a predetermined section of the well. Agar, or other immobilizing agent, may be added to the wells in order to immobilize the target cells. After which, the target cells are incubated and periodically analyzed to determine whether the target cells are growing, thereby indicating that the microorganisms are contained within the well.Type: ApplicationFiled: April 29, 2024Publication date: October 31, 2024Applicant: Microsensor Labs, LLCInventors: Peng Liu, Zerikhun Filatov
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Publication number: 20240361309Abstract: The present disclosure provides systems and methods for determining a property of target analyte in a sample. The systems and methods use a sensor assembly comprising plural sensing sites, each of the sensing sites comprising a capture species configured to specifically bind with the same target analyte. Each capture species is different and has a different binding affinity for the target analyte to the capture species on the other of the plural sensing sites.Type: ApplicationFiled: April 28, 2023Publication date: October 31, 2024Inventors: Andrew SPARKS, Helen BERNEY
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Publication number: 20240361310Abstract: Disclosed are capture beads that are suitable for use in an assay device which is configured to correlate the capture bead to a specific examination area in the device as well as correlating any captured nucleic acid or other cellular components generated during the assay to that bead.Type: ApplicationFiled: June 5, 2024Publication date: October 31, 2024Applicant: Zafrens Inc.Inventors: Kandaswamy Vijayan, Ravi Ramenani, Chulmin Choi, Aurelien Laguerre, Gopichandran Ravichandran, Nicholas Sam-Soon, Yi Zhang, David Milliken, Kenneth Chng, Maina Ndungu
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Publication number: 20240361311Abstract: An object of the present disclosure is to provide a control glass slide containing a control substance in a form in which the control glass slide is capable of preventing outflow of a dye generated by staining of the control substance for the purpose of accuracy control in a pathological examination. One aspect of the present embodiment is a control glass slide for a pathological examination, including a control spot on a glass slide, the control spot containing a control substance in the pathological examination and a dye trapping material.Type: ApplicationFiled: May 12, 2022Publication date: October 31, 2024Applicant: Hitachi High-Tech CorporationInventors: Taira SASAKI, Masashi MARUYAMA, HIrotaka SAKUMA, Toshinari SAKURAI, Shigeki MATSUBARA
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Publication number: 20240361312Abstract: The present invention provides a method for evaluating severity or prognosis of a patient with mixed connective tissue disease, which includes 1) a step of bringing a biological sample separated from a patient with mixed connective tissue disease into contact with a carrier in which an antigen containing one or more of component proteins of survival motor neuron complex or an antigenic partial peptide thereof is immobilized on a solid phase to form a complex of an autoantibody in the biological sample and the antigen immobilized on the solid phase, 2) a step of detecting the autoantibody in the complex of the autoantibody and the immobilized antigen, and 3) a step of associating the patient with a severe mixed connective tissue disease or a poor prognosis when the autoantibody is detected from the biological sample separated from the patient in step 2).Type: ApplicationFiled: February 5, 2024Publication date: October 31, 2024Applicant: UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, JAPANInventors: Yoshiya TANAKA, Satoshi KUBO, Minoru SATOH
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Publication number: 20240361313Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.Type: ApplicationFiled: December 8, 2023Publication date: October 31, 2024Applicant: Trustees of Boston UniversityInventors: Derin Sevenler, M. Selim Ünlü
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Publication number: 20240361314Abstract: Compositions and methods are provided for detection, diagnosis and prognosis of Lyme disease (LD), including a method for confirming Borrelia spp. infection by contacting, in vitro, whole blood samples from subjects suspected of having LD with synthetic peptides comprising T-cell epitope-containing regions derived from Borrelia proteins that are expressed at different stages of Lyme disease, and indirectly detecting LD-specific activated T-cells by determining production of a T-cell immune response indicator (e.g., interferon-Y) in response to stimulation by the peptides.Type: ApplicationFiled: July 9, 2024Publication date: October 31, 2024Inventors: Steven M. Callister, Jeff Boyle, Misato Miyamasu, Raymond Dattwyler, Paul M. Arnaboldi
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Publication number: 20240361315Abstract: The present invention relates to a method for labeling an analyte in a sample, said method comprising (a) providing a detection agent binding to the analyte and conjugating said detection agent with an indicator agent to produce a conjugation product; (b) contacting said sample with said conjugation product of step (a); wherein said step (b) is performed directly after completion of step (a) and wherein steps (a) and (b) are performed by the same labeling device; and to labeling devices, systems, and uses related thereto.Type: ApplicationFiled: April 24, 2024Publication date: October 31, 2024Inventor: Jan-Gerrit Hoogendijk
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Publication number: 20240361316Abstract: Disclosed herein are assay methods and kits for assessing the strength of the immune response to SARS-CoV-2 virus in a subject by allowing for rapid and efficient detection of neutralizing antibodies (NAbs) from serum of vaccinated and non-vaccinated subjects. The assay method can be conducted in a biosafety level 2 setting, and uses highly-purified, monomeric SARS-Cov-2-Spike1 which leads to improved sensitivity and specificity over current state of the art assays.Type: ApplicationFiled: July 25, 2022Publication date: October 31, 2024Inventors: Janean A. YOUNG, Jody BERRY
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Publication number: 20240361317Abstract: The present invention relates to a composition comprising: —either at least ethyl-?-D-glucuronide, the ethyl part of which comprises at least one non-radioactive isotope (or ethyl-?-D-glucuronide probe) and at least ethyl-?-D-galactopyranoside (or ethyl-?-D-galactopyranoside probe), the ethyl part of which comprises at least one non-radioactive isotope; —or at least ethyl-?-mannopyranoside, the ethyl part of which comprises at least one non-radioactive isotope (or ethyl-?-D-glucuronide probe); for use thereof as a diagnostic and/or prognostic agent.Type: ApplicationFiled: June 22, 2022Publication date: October 31, 2024Inventors: Pauline POINOT, Sébastien PAPOT, Justin LANGE, Fabiola DJAGO, Estelle BLOCHOUSE
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Publication number: 20240361318Abstract: The present technology is directed to methods of preparing affinity chromatographic columns using streptavidin-conjugated particles and biotinylated affinity agents (i.e., biotinylated oligonucleotides, biotinylated antibodies or biotinylated antigen-binding fragments thereof). The methods of the present technology can be utilized to perform affinity capture assays in a high-throughput, efficient manner. Further, the affinity chromatographic columns disclosed herein are customizable due to the ability to utilize any biotinylated affinity agent. The methods herein utilize an on-line loading (i.e., loading the column with biotinylated affinity agent via a liquid chromatography system).Type: ApplicationFiled: April 26, 2024Publication date: October 31, 2024Applicant: Waters Technologies CorporationInventors: Kevin Wyndham, Beatrice Muriithi, Martin Gilar, Yeliz Tunc Sarisozen
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Publication number: 20240361319Abstract: The present invention provides improved immunofocus assays for determining the virus titer of dengue viruses and the use thereof in the quality control of vaccines based on live attenuated dengue viruses or in the diagnosis of a blood sample from a dengue infected individual.Type: ApplicationFiled: September 9, 2022Publication date: October 31, 2024Inventors: Betty Elena LUY, Shi Hsia HWA, Steven Michael ERB, Jill A. LIVENGOOD, Andrew Montgomery THOMSON
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Publication number: 20240361320Abstract: A functionalized electrode capable of selectively interacting with a viral biomarker, an electrochemical system comprising the electrode and methods utilizing same for, for example, determining a presence of a viral infection in a subject are provided.Type: ApplicationFiled: July 10, 2024Publication date: October 31, 2024Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Ella BORBERG, Eran GRANOT, Fernando PATOLSKY
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Publication number: 20240361321Abstract: System for detecting an antigen comprising: —a first fusion protein with no luciferase activity comprising: —a N-terminal domain which comprises a first single domain antibody which is directed against a first epitope of said antigen and —a C-terminal domain which comprises a first fragment of a luciferase having the amino acid sequence SEQ ID NO: 1 or is a variant thereof and —a second fusion protein with no luciferase activity comprising: —a N-terminal domain which comprises a second single domain antibody which is directed against a second epitope of said antigen and —a C-terminal domain which comprises a second fragment of a luciferase having the amino acid sequence SEQ ID NO: 2 or is a variant thereof. Luminescence is emitted in the presence of a substrate when both the first fusion protein and the second fusion protein bind to said antigen.Type: ApplicationFiled: August 23, 2022Publication date: October 31, 2024Inventors: Thierry ROSE, Sophie GOYARD, Yves JANIN, Pierre LAFAYE, Gabriel AYME, Nicolas ESCRIOU, Marion GRANSAGNE
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Publication number: 20240361322Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.Type: ApplicationFiled: December 13, 2023Publication date: October 31, 2024Applicant: Meso Scale Technologies, LLC.Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin
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Publication number: 20240361323Abstract: The present disclosure provides for cancer treatment methods related to the unexpected discovery of the role of mannan-binding protein-associated serine protease-2 (MASP-2) in cancer. Improved cancer treatment methods are disclosed that are determined by measuring changes in levels of MASP-2, a previously unknown biomarker for cancer. It has been discovered that changes in MASP-2 levels are useful as indications of cancer progression, chemotherapeutic responsiveness, and cancer remission, such as in pancreatic cancers. More particularly, changes of levels in MASP-2 in extracellular vesicles (EVs), i.e. EV-MASP2, from patient blood samples are useful for providing effective and targeted cancer treatment regimens, such as in pancreatic cancers. The present disclosure further includes compositions and methods related to inhibiting MASP-2 for the treatment of cancers.Type: ApplicationFiled: April 30, 2024Publication date: October 31, 2024Inventors: Richard C. FRANK, Shatovisha DEY, Deep Siddhartha PANDYA
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Publication number: 20240361324Abstract: p80 is a cancer/proliferation-related protein identified as being present in bodily fluids or tissues (including blood) of humans or animals afflicted with pre-malignant, malignant cells/tissues or proliferative conditions. The methods of the present disclosure provide a new diagnostic marker for screening of cancers and proliferative conditions. The present application discloses screening, diagnosis, and monitoring of these conditions by novel Point-of-Service tests. The addition of p80-bound tubulin testing is also claimed. Additionally, the present application discloses targeted treatment of cancer and proliferative conditions utilizing p80 binding agents, via a variety of delivery vehicles such as nanoparticles. The claims apply to application in domestic or wild animals.Type: ApplicationFiled: February 26, 2024Publication date: October 31, 2024Inventors: Ahmed Fadiel-Metwaly, Frederick Naftolin
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Publication number: 20240361325Abstract: Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis.Type: ApplicationFiled: July 8, 2024Publication date: October 31, 2024Inventors: John S. Condeelis, Allison S. Harney
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Publication number: 20240361326Abstract: A method of detecting hepatocellular carcinoma (HCC) biomarkers in exosomes isolated from a blood sample obtained from a human subject is provided, by detecting in the sample two or more exosomal HCC biomarkers. The subject can be a healthy patient, a patient suspected of having a liver disorder, a patient previously diagnosed with liver cirrhosis, or a patient previously diagnosed with liver fibrosis.Type: ApplicationFiled: July 8, 2022Publication date: October 31, 2024Inventor: Laura BERETTA
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Publication number: 20240361327Abstract: The present invention provides systems and compositions for detecting circulating tumor cells (CTCs), and methods thereof. The systems of the present invention can image (e.g., via planar imaging) one or more cells (e.g., embedded in a solid or semi-solid medium, such as a gel) and analyze the cells, to identify one or more CTCs from the one or more cells.Type: ApplicationFiled: March 5, 2024Publication date: October 31, 2024Inventor: Triantafyllos P. TAFAS
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Publication number: 20240361328Abstract: The present invention discloses a versatile application of a multimer technology for detecting, manufacturing, and profiling chimeric antigen receptor (CAR)-expressing cells. These antigen-multimers exhibit remarkable specificity, sensitivity, and precision in identifying CAR cells. Moreover, they facilitate over 100-fold magnetic enrichment of rare CAR-T cells, enhancing their detectability. Beyond CAR detection, the multimer technology selectively stimulates CAR-expressing cells, both in soluble and surface-bound formats, during CAR-T cell manufacturing. Unlike existing technologies (such as anti-CD28/CD3 magnetic beads) that non-specifically stimulate and expand all T cells, the multimer approach ensures that only CAR-expressing cells are targeted. Consequently, this yields a CAR-T cell product with significantly higher purity, enhancing treatment efficacy. Furthermore, the multimer technology offers flexibility in CAR detection through nucleotide labeling.Type: ApplicationFiled: April 25, 2024Publication date: October 31, 2024Inventor: JUN HUANG
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Publication number: 20240361329Abstract: The disclosure provides a sample testing method and a sample analyzer, the method including: obtaining a sample to be tested; providing a reagent, the reagent including a hemolytic agent, a first fluorescent dye and a third fluorescent dye; mixing the sample and the reagent to form a sample solution; making the sample solution flow in a flow cell in a single test, irradiating the particles by using a first light source and a second light source, and detecting scattered light signals, first fluorescence signals and third fluorescence signals; obtaining a classification result and/or a counting result of white blood cells in the sample to be tested based on the first fluorescence signals and the scattered light signals; and obtaining a counting result of nucleated red blood cells in the sample to be tested based on the third fluorescence signals and the scattered light signals.Type: ApplicationFiled: July 10, 2024Publication date: October 31, 2024Inventors: Gengwen CHEN, Ziqian ZHANG
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Publication number: 20240361330Abstract: The present invention relates to a method of relativizing signals by using a neoglycoprotein as a standard for glyco-proteins, wherein said neoglycoprotein comprises a streptavidin molecule bound through biotin to at least one pre-defined glycan determinant which comprises said glycan structure (A) and a corresponding use of said neoglycoprotein. Thereby, statements whether a particular glycan structure (A) is present on a protein of interest are possible. Applications in diagnosis of diseases such as cancer, autoimmune disease or inflammatory disease are disclosed.Type: ApplicationFiled: August 5, 2022Publication date: October 31, 2024Inventors: Jan Tkac, Tomas Bertok
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Publication number: 20240361331Abstract: The present disclosure generally relates to systems and methods for analysis of peptide photodissociation for single-molecule protein sequencing. In one aspect, systems and methods are directed to allowing one to fragment a single protein molecule in aqueous solution so that its composition and sequence of amino acids can be measured by mass spectrometry. This may be useful for single-molecule protein sequencing technology.Type: ApplicationFiled: August 18, 2022Publication date: October 31, 2024Applicant: Brown UniversityInventors: Derek M. Stein, Jacob Sage Vietorisz, Nicholas Drachman
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Publication number: 20240361332Abstract: An object of the present invention is to provide a method of identifying an amino acid site in a protein, to which a sugar is bound more accurately than in the related art, and a kit for performing the method. According to the present invention, there is provided a method for identifying an amino acid site in a protein, to which a sugar is bonded, the method including a first mass spectrometry step of subjecting a fragmented protein to mass spectrometry; for a protein in which the bonding of the sugar has been confirmed in the first mass spectrometry step, a substitution-modification step of substituting and/or modifying an amino acid of the protein at the amino acid site in the protein, to which the sugar is bonded and a fragmentation step of fragmenting the protein; and a second mass spectrometry step of subjecting the substituted and/or modified, and fragmented protein obtained by the substitution-modification step and the fragmentation step, to mass spectrometry.Type: ApplicationFiled: July 5, 2024Publication date: October 31, 2024Applicant: FUJIFILM CorporationInventor: Shun MATSUDA
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Publication number: 20240361333Abstract: Disclosed herein are methods, compositions, and devices for the detection of neutralizing antibodies for a pathogen of interest. In some embodiments, a covalent coupling between a viral protein and a receptor protein is utilized to reduce dissociation of the viral protein/receptor complex.Type: ApplicationFiled: July 10, 2024Publication date: October 31, 2024Inventors: Ralph Eugene DAVIS, Humaira JANWARI, Ji Youn LIM, Aravind SRINIVASAN, David OKRONGLY, Sasha PEREBIKOVSKY, Brandon POLLACK, Marjorie CAPARAS, Alex HWU
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Publication number: 20240361334Abstract: The invention relates to a novel method for determining the binding of an antibody to the complement component 1q (C1q). The process according to the invention makes it possible to measure the binding of an antibody to the C1q in a Homogeneous Proximity Assay (HAS).Type: ApplicationFiled: May 11, 2022Publication date: October 31, 2024Applicant: CISBIO BIOASSAYSInventors: Najim DOUAYRY, Patrick MENSAT, Thomas ROUX, Julie VALLAGHE, Eric TRINQUET
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Publication number: 20240361335Abstract: Given a set of therapeutic epitopes, a cassette sequence is designed to reduce the likelihood that junction epitopes are presented in the patient. The cassette sequence is designed by taking into account presentation of junction epitopes that span the junction between a pair of therapeutic epitopes in the cassette. The cassette sequence may be designed based on a set of distance metrics each associated with a junction of the cassette. The distance metric may specify a likelihood that one or more of the junction epitopes spanning between a pair of adjacent epitopes will be presented.Type: ApplicationFiled: November 8, 2023Publication date: October 31, 2024Inventors: Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky, Jennifer Busby
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NEWBORN SCREENING FOR CONGENITAL HEART DEFECT USING CARDIOVASCULAR BIOMARKERS IN DRIED BLOOD SAMPLES
Publication number: 20240361336Abstract: Methods of detection of congenital heart defect (CHD) in a newborn human patient, are provided according to aspects of the present disclosure which include: performing an assay for one or more biomarkers of CHD selected from the group consisting of: soluble Suppression of Tumorigenicity 2 protein (sST2), and Galectin-3 in a dried blood sample obtained from the newborn human patient, thereby determining a level of one or both biomarkers present in the dried blood sample. The determined level of the biomarker(s) present in the dried blood sample is compared with a standard representing a normal newborn control without CHD, thereby determining whether the determined level is increased or decreased compared to the standard, wherein an increased level of one or both biomarkers present in the dried blood sample, compared with a standard representing a normal newborn control without congenital heart defect, indicates detection of CHD in the newborn human patient.Type: ApplicationFiled: April 26, 2024Publication date: October 31, 2024Inventor: Mikko Sairanen -
Publication number: 20240361337Abstract: Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.Type: ApplicationFiled: May 10, 2024Publication date: October 31, 2024Inventors: James L. Cook, Aaron M. Stoker, Chantelle C. Bozynski, Keiichi Kuroki, Cristi R. Cook, Emily Leary
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Publication number: 20240361338Abstract: The present disclosure provides methods of detection and diagnosis of ectopic endometriosis. The disclosure further provides compositions, medicaments and methods for treating or preventing ectopic endometriosis.Type: ApplicationFiled: August 30, 2022Publication date: October 31, 2024Applicant: FERRING B.V.Inventors: Torsten M. REINHEIMER, Glenn E. CROSTON, Benedetta BUSSOLATI
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Publication number: 20240361339Abstract: The present disclosure relates to the treatment of Parkinson's disease with granulocyte-macrophage colony-stimulating factor, as well as diagnostic, prognostic and patient selection methods.Type: ApplicationFiled: September 1, 2022Publication date: October 31, 2024Inventors: Howard GENDELMAN, R. Lee MOSLEY, Mai MOSTAFA, Katherine OLSON, Jatinkumar MACHHI
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Publication number: 20240361340Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.Type: ApplicationFiled: July 5, 2024Publication date: October 31, 2024Inventors: Alexander J.A. TRAVIS, Roy COHEN
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Publication number: 20240361341Abstract: Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.Type: ApplicationFiled: April 4, 2024Publication date: October 31, 2024Inventors: Daniel B. Lookadoo, Ashok A. Kumar, Jeremy E. Schonhorn, Christopher M. Uherek, Michal Depa
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Publication number: 20240361342Abstract: Screening methods and devices for detecting and diagnosing hemoglobinopathies for sickle cell disease and related phenotypes. Lateral flow immunoassay devices for the detection of hemoglobinopathies. Methods for screening for hemoglobinopathies. Kits for the detection of a hemoglobinopathy in a sample. Immunogenic peptides for producing antibodies against hemoglobin variants.Type: ApplicationFiled: May 13, 2024Publication date: October 31, 2024Applicant: BioMedomics, Inc.Inventors: YiTing Cao, XiaoXi Yang, XueFeng Wang
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Publication number: 20240361343Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: ApplicationFiled: July 12, 2024Publication date: October 31, 2024Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Publication number: 20240361344Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.Type: ApplicationFiled: July 11, 2024Publication date: October 31, 2024Inventors: Brett Holmquist, Nigel Clarke, Anne Caston, Richard E. Reitz
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Publication number: 20240361345Abstract: The present application describes methods and systems for measuring and controlling oxidative stress in animals and humans. The degree of oxidative stress can be measured directly by inducing all of the blood cells to produce excessive reactive oxygen species (ROS) by exposure to an elevated concentration sulfide or other ROS inducing chemical and measuring the fluorescence intensity of a fluorescent dye or color intensity of dye that reacts with ROS. Oxidative stress can be reduced by reducing dietary sulfur, consumption of a methanogenic probiotic, or apheresis methods to replace ROS-positive blood cells with normal blood cells. Plasma oxidative stress can be compared in venous and arterial blood samples to evaluate small vessel disease. Oxidative stress can be increased by increasing dietary sulfur or the use of an intravenous method that exposes blood cells to an elevated blood concentration of sulfide or other ROS inducing chemical.Type: ApplicationFiled: July 8, 2024Publication date: October 31, 2024Inventor: Peter Stroot
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Publication number: 20240361346Abstract: An automatic analyzer is provided that is capable of quickly responding when an abnormal process occurs, accurately grasping an abnormal state, and reducing frequencies of early abnormality diagnosis and component adjustment or replacement of the automatic analyzer. The automatic analyzer compares data output information with reference data output information, applies a data alarm to an item of the data output information determined to be in an abnormal state, compares system output information with reference system output information, applies a data alarm to an item of a data output information determined to be in an abnormal state, and executes a predictive diagnosis of a failure state of the automatic analyzer based on a temporal change of the data output information obtained by the analyzer using an internal standard substance as a sample and a temporal change of the system output information.Type: ApplicationFiled: February 2, 2022Publication date: October 31, 2024Applicant: Hitachi High-Tech CorporationInventors: Makoto NOGAMI, Riku TAMURA, Kenichiro NISHIKI, Takayuki SUGIME, Yuichiro HASHIMOTO, Toshiaki KATANO, Masuyuki SUGIYAMA
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Publication number: 20240361347Abstract: According to one embodiment, a sample preparation cartridge includes, in a container, a first capture unit which captures an inclusion, a second capture unit provided spaced apart from the first capture unit, which captures a contaminant, a first space provided on one surface side of the first capture unit, a second space provided on one surface side of the second capture unit, and an inflow channel on the other surface side of the second capture unit, the second space is provided in parallel with the first space, and the first space and the second space are communicated to a third space between the first capture unit and the second capture unit.Type: ApplicationFiled: April 18, 2024Publication date: October 31, 2024Applicant: Canon Medical Systems CorporationInventor: Shozo HASHIMOTO
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Publication number: 20240361348Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.Type: ApplicationFiled: April 19, 2024Publication date: October 31, 2024Inventors: Alexandre VLASSOV, Timothy BARTA, Justin INSLEE, Ethan GENTERT, Robert SMITH, Sara THIELE, Carolyn ADAMS, Kraig KRUGER, Robert Schneider, Wade LUKIANOW, Jay GRECO, Jason JONES, David CERRONE, Sumonto GHOSH, Brian VAJDA, Andrew BASTA, Allan EVANS, Christopher CROWLEY, Robert SETTERQUIST, Anne COX, Mark MAYERNICK