Abstract: A fluid handling device of the present invention includes a first molded article that includes a first through hole. The fluid handling device includes a burr prevention portion, extending in the circumferential direction of the first through hole, on the inner peripheral surface of the first through hole.

Abstract: According to one embodiment, an inspection cartridge includes a housing, a first flow path, a second flow path and a reservoir. The housing has an opening for dropping a test solution. The first flow path includes a first detection surface that is a lyophilic and has a substance that binds to the test solution on a surface. The second flow path includes second detection surface that is lyophilic and has a substance that binds to the test solution on a surface, the second flow path being parallel to the first flow path. The reservoir is formed below the opening and connected to the first flow path and the second flow path, the reservoir being liquid-phobic.

Abstract: A microfluidic device and a method for manipulating, and sensing at least one property of, cells or particles in a microfluidic channel are disclosed. The microfluidic device includes a microfluidic channel arranged on a substrate, a sensing zone arranged along a portion of the microfluidic channel, and a set of piezoelectric actuators arranged in proximity to the sensing zone. The sensing zone is configured to measure one or more properties of a cell or a particle in a fluid sample in the microfluidic channel. The set of piezoelectric actuators is configured to cause manipulation of the particle while the particle is in the sensing zone.

Abstract: The present subject matter relates to devices and techniques for reducing the parabolic velocity profile. The disclosed device can include a coflow generator configured to receive a buffer solution and a mixture of at least two components to form a coflow pattern in a tubing, and a coflow separator configured to seperate the buffer solution from the reaction mixture. The coflow generator and the coflow separator can be coupled through the tubing. The tubing can be configured to receive the mixture and the buffer solution from the coflow generator and have the mixture bounded by the buffer solution without contacting a wall of the tubing.

Abstract: A present inventive concept relates to a microfluidic arrangement comprising: a first section having a first plane and comprising a trigger channel and a stop channel, wherein the trigger channel and the stop channel are parallel with the first plane; wherein the trigger channel has a first portion having a first depth, and a second portion having a second, deeper, depth, the trigger channel being arranged to allow a liquid flow to the second portion from the first portion; and wherein the stop channel has an opening that fluidically connects the stop channel to the second portion of the trigger channel at a predetermined distance from a bottom of the trigger channel; the microfluidic arrangement further comprising: a second section having a second plane having a third portion comprising a plurality of elongated recesses, wherein the plurality of recesses are arranged separated from each other; wherein the first section and the second section are arranged with the first and the second planes in parallel, and

Abstract: Flow cell devices, cartridges, and systems are described that provide reduced manufacturing complexity, lowered consumable costs, and flexible system throughput for nucleic acid sequencing and other chemical or biological analysis applications. The flow cell device can include a capillary flow cell device or a microfluidic flow cell device.

Abstract: An automatic sample preparation system is disclosed. The automatic sample preparation system integrates sample pretreatment, extraction, quantitation, and solution preparation into one system. A replacement of manual operations with an automatic system can reduce time and labor costs, reduce human errors, and reduce contamination risk.

Abstract: The present invention is directed to a system and method for digital, multiplexed, extracellular vesicle-derived biomarker diagnostic lab-on-a-chip and method of use thereof. The present invention provides a minimally invasive system and method for early disease detection using extracellular vesicles as biomarkers for disease. Extracellular vesicles are collected from a fluid biological sample and subjected to a sorting process which provide a purified liquid containing the biomarkers of interest.

Abstract: A liquid delivery apparatus according to an embodiment is provided with a reservoir part, a pipe, and a liquid delivery part. The reservoir part stores therein a first liquid and a second liquid that is immiscible with the first liquid and has a different specific gravity from that of the first liquid. One end of the pipe is coupled to the reservoir part and the other end thereof is coupled to a liquid delivery destination of the first liquid. The liquid delivery part extrudes the first liquid and the second liquid in this order from the reservoir part to the pipe to deliver the first liquid to the liquid delivery destination.

Abstract: This invention pertains to a novel method of single cell sequencing where cellular observations are paired directly with sequences. This method consists of a sequencing element with barcoded solid-phase PCR probes, cellular wells, and an optional cellular trap. Cells are loaded with reagents directly into wells or captured with cellular traps where the cellular wells are then lowered over the trapped cells. The sequencing element is then added. Cellular observations such as binding and affinity are then recorded. Cells are lysed and RT-PCR is performed to create a cDNA library that is then sequenced. Barcodes in the library allow sequences to be mapped back to individual wells. This method has applications from basic biology to personalized drug discovery to creating large databases for machine learning training sets.

Abstract: A buckled member sensing device comprising a flexible sensing member, rigid base member, and compressive element is disclosed in the present invention. When constrained by the rigid base member and the compressive element, the flexible sensing member may change shape to form a buckle. An active element formed from material reactive to specific external stimuli may be disposed of on the buckle of the flexible member. External stimuli that may react with the active element may include chemical, bioagent, heat, air, pressure, radiation, gravity, magnetic, and electromagnetic stimuli. Upon detection of external stimuli, stress may be induced in the active element in the form of surface stress, electromagnetic force, electrostatic force, mechanical force, floating force, fluid pressure, gravity, thermal stress, temperature change, or chemical reaction force.

Abstract: A microfluidic droplet injector (MDI) for serial femtosecond crystallography (SFX). The MDI includes a droplet generator, a droplet detector, and a nozzle.

Abstract: In some aspects, the presently disclosed subject matter provides a microfluidics system, instrument, and cartridge including multi-sided digital microfluidic (DMF) dispensing and method of use. In other aspects, the presently disclosed invention is directed to computer readable storage medium comprising instructions, which to: load a multi outlet digital microfluidic device dispenser with a liquid; dispense a first portion of the liquid from a first outlet; dispense a second portion of the liquid from a second outlet; perform a first analysis on the first portion of the liquid; perform a second analysis on the second portion of the liquid; and present results of the first analysis.

Abstract: The present subject matter relates to devices and techniques for preparing a sample. The disclosed device can include a mixer, a reaction channel, and a micro sprayer. The mixer can be configured to mix at least two components and perform a splitting and recombination (SAR) mixing. The micro sprayer can be configured to generate a droplet of the sample. The mixer and the micro sprayer can be coupled through the reaction channel. The reaction channel can be a microcapillary tubing or a yin-yang reaction channel.

Abstract: Provided is an electrowetting-on-dielectric (EWOD) device. The EWOD device comprises a first substrate and a second substrate opposite to the first substrate. The first substrate comprises a plurality of first electrodes configured to be respectively controllably connected to signal lines. The first hydrophobic layer disposed over the plurality of first electrodes. The second substrate comprises a second electrode configured to be connected to the signal lines. The second hydrophobic layer disposed over the second electrode. An internal space between the first substrate and the second substrate is provided for receiving a droplet and a surrounding medium. The droplet is surrounded by the surrounding medium.

Abstract: A sample retention card is disclosed which can simplify processing of samples, identification of subjects' personal information, and the like, and also facilitates automation. The sample retention card includes: a sample carrier composed of a porous sheet and a frame surrounding the periphery of the porous sheet, the frame having an outer edge with a circular or regular polygonal shape. The porous sheet has both surfaces thereof exposed from the frame. The arrangement of the frame improves the handling of the porous sheet and eliminates the need to manually adjust the direction of the card when it is used in a testing device because the outer edge of the frame is circular or regular polygonal. The porous sheet can be punched out with a punch from each surface thereof because both surfaces of the porous sheet are exposed from the frame. This also simplifies the testing and eliminates the need to manually adjust the direction of the card when it is used in the testing device.

Abstract: An apparatus for controlled separation of a labware from a thermocycler. A thermal block has a slot along a lateral edge thereof. A gear rack includes a set of teeth that are linearly aligned along an upper edge thereof. A gear is positioned to engage the set of teeth such that the gear rotates with lateral movement of the gear rack. A lifting pin is associated with the gear and the lifting pin extends from a position that is offset from a central axis of the gear and toward the thermal block. The lifting pin is disposed proximate to the lateral edge of the thermal block such that, in a first position, the lifting pin is located resting in the slot, and in a second position, the lifting pin is located above the thermal block.

Abstract: A specimen holder includes a body, a sleeve, and a wireless transponder. The body has distal and proximal portions, the distal portion including a surface that carries a specimen upon engagement of the body with the specimen, and the proximal portion including a first pair of parallel surfaces. The sleeve has distal and proximal portions, a side wall, and an internal cavity at least partially enclosed by the side wall. The distal portion of the sleeve includes a second pair of parallel surfaces. The wireless transponder is sized to be positioned within the internal cavity of the sleeve. The sleeve is attachable to the body by capturing one of the first and second pairs of parallel surfaces between the other of the first and second pairs of parallel surfaces.

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are scaled.

Abstract: An apparatus for controlled separation of a labware from a thermocycler lid. The apparatus includes a seal plate configured to be secured to the thermocycler lid. The seal plate has a seal plate top surface, and a seal plate bottom surface configured to receive a labware seal. A pin is mounted together with a spring on the seal plate at a lateral edge thereof to provide a controlled release of the labware from the thermocycler lid. The spring is disposed to force the pin against an upper edge of the labware such that upon opening the thermocycler lid, the spring causes the pin to extend in contact with the labware, and thereby cause a separation of the labware from the seal plate.

Abstract: An extraction device assembly for extracting a sample from a sample-containing chamber of a nucleic acid amplification cartridge is provided. The assembly has a cartridge interface forming a receptacle configured to at least partially fit the sample-containing chamber therein. The cartridge interface has an aperture configured to at least partially expose the sample-containing chamber, and a collection interface having an aperture configured to at least partially align with the cartridge interface aperture and with the sample-containing chamber positioned at least partially between them. The collection interface aperture is in fluid communication with a collector. The extraction device assembly is operable to fit the sample-containing chamber in the receptacle of the cartridge interface and guide a piercing tool into the cartridge interface aperture to pierce the sample-containing chamber and liberate a sample contained therein for transferral to the collector.

Abstract: A mantle for a gyratory or cone crusher that includes a frame having a bowl as a first crushing shell, and a crusher head including the mantle as a second crushing shell, wherein the mantle and bowl define a crushing gap between them. The mantle includes a central axis, a first end and a second end along the central axis, and an outer peripheral surface defined by a generatrix rotating around the central axis. The outer peripheral surface constituting a crushing surface of the mantle, and an outer diameter of the mantle being larger at the second end than at the first end. One or more grooves are formed in the crushing surface at the second end of the mantle, and one or more cavities for receiving wear resistant inserts are formed in the crushing surface. One or more wear resistant inserts are bonded to or into the crushing surface.

Abstract: A wear plate for a rotor for a comminution apparatus that is arrangeable adjacent to at least one of the wall elements and/or a further wear plate. The wear plate extends between an upper plate and a lower plate along a longitudinal direction. The wear plate includes a first body extending along a first general direction and has an upper surface, a lower surface, and a first abutment surface extending at least partially between the upper and lower surfaces. The wear plate includes a second body extending along a second general direction differing from the first general direction and has an upper surface, a lower surface, and a second abutment surface extending at least partially between the upper and lower surfaces. The wear plate is configured to abut a first surface and a second surface of the rotor such that, in use, forming a self-locking mechanism due to rotational force.

Abstract: There is provided a scrap crushing and carrying apparatus, including: a coarse crusher for crushing scraps; a fine crusher for further crushing the scraps crushed by the coarse crusher; and a carrier for storing the scraps or carrying the scraps to the coarse crusher or the fine crusher. The carrier includes a filter unit provided inside the carrier to collect dust in the carrier.

Abstract: A safety system prevents cutting machine operators from being accidentally carried through the infeed chute into the machine's cutting mechanism. An operator wears a safety device on his wrist and/or ankle and a sensor array mounts on opposing sides of the cutting machine's infeed chute. The sensor array elements are wound in opposite directions and connect in series opposing. The magnetic field of the safety device induces a current in the sensor array as it moves in the proximity of the sensor array. The safety system generates a signal which is proportional to the sum of the induced currents. When the signal exceeds a threshold, the safety system shuts off power to the feed mechanism and/or the cutting blades of the cutting machine, preventing injury to the operator.

Abstract: A classification system using a fluidized bed according to the present invention includes: a fluidized bed classifier supplied with powder containing particles of different sizes, which entrains the powder into the fluidized gas, and then discharges coarse powder through a coarse powder outlet positioned in its lower portion. The system further includes a cyclone communicating with an upper portion of the fluidized bed classifier, which collects and discharges fine powder contained in the fluidized gas transferred from the fluidized bed classifier to a fine powder outlet positioned in its lower portion. Additionally, the system further includes a plurality of internal structures positioned in the fluidized bed in the fluidized bed classifier which reduce a size of a bubble of the fluidized gas.

Abstract: A gravel circulation dry electrostatic precipitator includes: a drying unit (S1) which conveys and uniformly mixes, heats, and dries recycled aggregates, containing a large amount of moisture, among the materials of asphalt-concrete; a first dust collection and purification unit (S2); a second dust collection and purification unit (S3) in which fine dust, remaining after the odor-inducing substances, harmful gases, and dust that have passed through the first dust collection and purification unit (S2) are filtered by a filter, is discharged to the outside by a screw(S) provided at the lower end of a hopper, and a discharge unit (S4) which uses a turbo fan (F) to forcibly suction fresh air that has passed through the second dust collection and purification unit (S3), thereby discharging same via an outlet (400).

Abstract: A method of recovering a concentrated plant-based protein suspension comprises use of a high-speed centrifugal separator comprising a frame, a drive member and a centrifuge bowl. The drive member rotates the centrifuge bowl in relation to the frame. The centrifuge bowl encloses a separation space comprising a stack of separation discs, and comprises an inlet for receiving a plant-based protein suspension comprising suspended particles, a liquid light phase outlet for a separated liquid light phase and a liquid heavy phase outlet for a separated liquid heavy phase. The plant-based protein suspension is fed to the centrifugal separator inlet, and the plant-based protein suspension is separated into a liquid light phase and a liquid heavy phase, which comprises the concentrated protein suspension. The concentrated plant-based protein suspension is removed as the liquid heavy phase through the heavy phase outlet by influencing the discharge flow by way of a liquid flow influencer.

Abstract: A fluid filling nozzle may include a nozzle part configured to guide a fluid from an interior thereof along a reference direction, a rotation part coupled to a side of the nozzle part in the reference direction such that an end thereof in an opposite direction to the reference direction is rotatable, and a guide part, in which the nozzle part is disposed in an interior thereof, and that is configure to guide the nozzle part to move parallel or antiparallel to the reference direction. The guide part May be configured to engage a portion of the rotation part such that the rotation part is rotated if the guide part is moved parallel or antiparallel to the reference direction.

Abstract: A misting nozzle assembly that includes a manifold having a fluid entry point and a plurality of ports formed therein each of which is fluidly connected to the fluid entry point. A plurality of nozzle is each adapted for attachment within a respective of the plurality of ports.

Abstract: A nozzle opening and closing device for electrolyte injection comprises a nozzle having a discharge outlet for injecting an electrolyte into a battery assembly. The nozzle opening and closing device for electrolyte injection further comprises an opening and closing plate rotatably mounted on the nozzle, and provided to open or close the discharge outlet of the nozzle, and an opening and closing control part provided to control whether the opening and closing plate is opened or closed based on the weight of the electrolyte applied to the opening and closing plate.

Abstract: A nozzle system includes a head part having a spray part formed at a location corresponding to a sensor part and a body part having a portion of the head part inserted thereinto and located therein. The body part includes an inlet part configured to allow fluid to flow into the body part therethrough. The nozzle system includes a delay part insertable into at least the portion of the head part and located in the body part. The delay part protrudes in a movement direction of the head part. The fluid flows into the body part and the head part is moved along the delay part and the fluid is sprayed out of the spray part of the head part when the head part is located at and clear of an end of the delay part.

Abstract: An adjustable rotary nozzle assembly in accordance with an embodiment of the present disclosure includes an upper valve element mounted in a drive element such that the upper valve element rotates with the drive element, wherein the drive element and upper valve element are mounted in a base and a lower valve element is mounted in a bottom of the base in a desired orientation relative to the base and the upper valve element such that the upper valve element and lower valve element cooperate to provide an adjustable arcuate slot opening though which water passes.

Abstract: According to the present disclosure, there is provided an electrostatic spraying device equipped with a spray nozzle spraying a liquid and a strip-shaped charging section charging the liquid sprayed from the spray nozzle, the electrostatic spraying device comprising: a power supply line which supplies power to the charging section; an electrical resistance member that constitutes a part of a power supply path from the power supply line to the charging section and allows a current flowing through the charging section to be weaker than a current flowing through the power supply line; and a housing which accommodates the electrical resistance member and into which the power supply line is drawn.

Abstract: According to the present disclosure, there is provided an electrostatic spraying device comprising: a spray nozzle which sprays a liquid (chemical solution); and a charging section which charges the liquid (chemical solution) sprayed from the spray nozzle, wherein the spray nozzle is provided with a distal end movable around a base end, and wherein the charging section has a shape along a movement path of the distal end.

Abstract: A spray gun for a plural component system is provided. The spray gun includes a first component delivery line and a second component delivery line. The spray gun also includes a nozzle, configured to receive and mix a first component received from the first component delivery line with a second component received from the second component delivery line. The spray gun also includes an air purge system configured to, when the spray gun is in a non-actuated position, purge the nozzle of the first and second components and, when the spray gun is in an actuated position, aid in atomization of the mixture of the first and second components.

Abstract: Dispensing devices are provided. Such devices utilize a combination of Flair® technology, pre-compression valves and aerosol-like pressurization of the dispensed liquid. An example dispensing device has, for example, a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a container and fills the pressure chamber with that liquid as a user operates a trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve. Liquid exiting the piston chamber under pressure enters a central vertical channel which is in fluid communication with both the pressure chamber and a dome valve, with pre-defined opening pressure, provided near the outlet channel at the top of the dispensing head.

Abstract: An assembly that includes a bottle with a neck, a dispensing unit with a reservoir in the bottle and a dispensing mechanism, wherein the dispensing unit has at least one groove, an aesthetic cap positioned on the neck and comprising a first plate and a first external skirt, and an attachment system secured to the aesthetic cap. The attachment system includes a second plate between the neck and the first plate, an internal skirt between the neck and the dispensing mechanism, a second external skirt between the neck and the first external skirt, and holding lugs secured to the internal skirt and which extend inwards to be housed in a groove.

Abstract: Provided is a trigger dispensing head applicable to a bottle of a trigger dispensing device having a cylinder chamber, a main vent passage, a sleeve, a secondary vent passage, a manually-operable piston, a suction duct, and a dispensing duct. The sleeve is provided with an annular inner sleeve wall delimiting a pressure chamber, and an annular outer sleeve wall externally spaced from the annular inner sleeve wall.

Abstract: A liquid dispensing device includes a dispensing head, an outlet valve and a nozzle. The dispensing head includes an inlet valve, a piston and a piston chamber, an actuator for controlling the piston, and a buffer or bladder. The outlet valve has a defined minimum opening pressure and is in direct fluid communication with either the buffer or bladder, or both the buffer or bladder and the piston chamber. The nozzle, with a defined throughput, is in fluid communication with the outlet valve. A volume of the piston chamber, a volume of the buffer, a pressure response of the buffer, the throughput of the nozzle, and the minimum opening pressure of the outlet valve are together arranged to restrict the outlet pressures of liquid droplets exiting the nozzle within a defined range of from (P??P) to (P+?P), where P is a nominal pressure and ?P a maximum pressure variation.

Abstract: A liquid dispenser has a liquid reservoir for storing liquid prior to discharge and a nozzle unit through which liquid is discharged in a discharge direction. The liquid dispenser also has an actuating handle actuable in a direction that deviates from the discharge direction in order to convey liquid from the liquid reservoir to the nozzle unit. The liquid dispenser has an inner housing to which the actuating handle is pivotably articulated, and an outer housing displaceable in a translational manner relative to the inner housing between a first end position and a second end position. The actuating handle and the outer housing have cooperating locking positions which prevent actuation of the actuating handle in the first end position and which allow actuation of the actuating handle in the second end position.

Abstract: A covering is provided to protect nozzles from outdoor elements while allowing the nozzle to discharge fluid when needed. The covering includes a water way portion with a cap, a lock ring, a clamp, and a flexible collar, and may also include a body cover attached to the water way portion and extending over the body of the nozzle. The cap is configured to cover the water way of the nozzle and is attached such that when pressure is applied from the water way, the cap is released allowing water to flow from the nozzle. The cap may then be reattached to the collar when the nozzle is not is use. In this way, the cover protects and covers fire nozzles up to the moment that the equipment is activated.

Abstract: A chemical supply apparatus is provided. The chemical supply apparatus includes a protecting structure, a peristaltic pump, and a fluid pipe. The protecting structure has a first opening and a second opening, and the second opening is located above the first opening. The peristaltic pump is disposed on the protecting structure. The fluid pipe is disposed in the protecting structure and the peristaltic pump. The first opening and the second opening are facing towards the same direction. The fluid pipe connects the first opening and the second opening. The peristaltic pump is configured to control fluid in the fluid pipe. The protecting structure is adapted to cover an outlet of a chemical fluid container. An operation method of a chemical supply apparatus is also provided.

Abstract: A method for a semiconductor manufacturing process includes circulating a solution from a tank using a pump and receiving the solution from the pump at an inlet of a valve. When a manufacturing operation occurs, the solution is directed to a first outlet of the valve that is connected to a nozzle used in the manufacturing operation. When the manufacturing operation is idle, the solution is directed to a second outlet connected to a recirculation path; and recirculated back to the tank via the recirculation path for re-use in the manufacturing operation.

Abstract: The invention relates to a device (1) for spraying and distributing liquid, having at least one connection element (8) for connecting to a liquid connection and at least one dispensing opening (3) for dispensing liquid. The present device addresses the problem of improving the known devices. This problem is solved in that the connection element (8) is arranged in a base element (5) of the device (1), said base element (5) being adjoined by a cover element (2) in which the at least one dispensing opening (3) is arranged, wherein the cover element (2) and base element (5) enclose at least one channel (4) which fluidically connects the connection element (8) to the at least one dispensing opening (3), wherein, between the cover element (2) and base element (5), at least one seal (5, 6) is provided which forms a boundary of the channel (4) in a radial direction over the entire height of the channel (4).

Abstract: An anti run-over (ARO) sprinkler device including a housing, sprinkler region and a run-over region. The sprinkler region includes a piston, first cap, first seal and a primary spring. The run-over region includes a second cap, second seal, secondary spring and a water inlet. The device operates to prevent damage to the device when unintentional force is applied thereto. The device includes a secondary spring which contracts when unintentional force is applied to the device to prevent damage to the device.

Abstract: A slot die coater includes an upper plate and a lower plate assembled with each other to form a discharge port; and a shim interposed between the lower plate and the upper plate to form a slot communicating with the discharge port. The upper plate has a groove recessed into the upper plate in parallel with the shim above the slot, and further includes a taper block and a pressure bolt fitted into the groove to press the shim.

Abstract: The present invention relates to a device designed to enhance the efficiency and environmental sustainability of applying various compounds used in construction and repair tasks. The device comprises a first connector end equipped with a set of threads, a customizable tip that is configured to be received by the first connector end, and a second connector end that features a cavity to securely receive the tip. The second connector end also includes a corresponding set of threads that engage with the threads of the first connector end to tighten the assembly, ensuring a robust and leak-proof connection. Additionally, the device includes a container of compound that attaches to the first connector end, allowing for a seamless and controlled flow of the compound through the device.

Abstract: Provided is a mask assembly and a method of manufacturing the same. The mask assembly according to one or more embodiments of the present disclosure may include a mask frame defining a first opening, an open mask above the mask frame, and defining second openings arranged in a first direction and a second direction crossing the first direction, unit masks above the open mask, and defining a unit opening, the unit opening having an area that is less than an area of each of the second openings in plan view, and cell masks above the unit masks, and defining cell openings, one of the cell openings have an area that is less than the area of the unit opening.

Abstract: One object is to suppress the surface of a substrate from being scratched in the course of a polishing process. There is provided a method of processing a substrate, comprising: a process of forming a protective film on an outer peripheral part of the substrate including a bevel portion, prior to a process of polishing the substrate, wherein the process of forming the protective film includes applying a protective film material in a liquid form onto the outer peripheral part of the substrate and curing the applied protective film material; and the process of polishing the substrate with the protective film formed on the outer peripheral part thereof.