Abstract: A sensor array includes a semiconductor substrate, a first plurality of FET sensors and a second plurality of FET sensors. Each of the FET sensors includes a channel region between a source and a drain region in the semiconductor substrate and underlying a gate structure disposed on a first side of the channel region, and a dielectric layer disposed on a second side of the channel region opposite from the first side of the channel region. A first plurality of capture reagents is coupled to the dielectric layer over the channel region of the first plurality of FET sensors, and a second plurality of capture reagents is coupled to the dielectric layer over the channel region of the second plurality of FET sensors. The second plurality of capture reagents is different from the first plurality of capture reagents.

Abstract: The present invention provides novel antigens of an allergy to wheat, methods and kits for diagnosing an allergy to wheat, compositions comprising such an antigen, wheat or processed products of wheat in which such an antigen is eliminated, and a tester composition for determining the presence or absence of a wheat antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an antigen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, compositions comprising such a polypeptide, and raw materials or processed products in which an antigen comprising such a polypeptide is eliminated or reduced. The present invention further relates to a tester composition for determining the presence or absence of an antigen in an object of interest.

Abstract: An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.

Abstract: A measurement method for a physical quantity change of an adhered substance that changes due to external stimulation includes: measuring a physical quantity change of the adhered substance on an adhesion target by causing a detection unit, in which the adhesion target and the adhered substance placed thereon are on a sensor including a crystal resonator, so as to resonate in a medium; and measuring change in a resonance frequency of the crystal resonator caused by external stimulation to the detection unit, wherein the external stimulation is chemical injection or a temperature change, wherein the change in the physical quantity is a change in an elastic modulus of the adhered substance, a change in an elastic modulus of a laminated part due to detachment of the adhered substance or a change in weight of the adhered substance, and wherein the medium is gas or liquid.

Abstract: The present disclosure provides a system and method for real-time visualization of a material during ultrasonic non-destructive testing. The system is capable of producing A-scans, B-scans, and C-scans of the test object and automatically highlighting potential foreign objects within the test object based on the scan data. The system includes a graphical user interface (GUI) capable of displaying a three-dimensional (3-D) image of a composite laminate constructed of a series of two-dimensional (2-D) cross sections. In one embodiment, the system includes an artificial intelligence module capable of highlighting foreign objects in order to provide size data, shape data, and/or depth data of the foreign object.

Abstract: A method of determining the time delay between echoes of an ultrasound pulse emitted by an ultrasound inspection device into an object, the method including: with the ultrasound probe in engagement with a front-wall feature of the object such that the ultrasound inspection device's ultrasound axis is arranged at an angle relative to the nominal surface normal of the front-wall feature, taking an ultrasound measurement which includes the ultrasound inspection device emitting an ultrasound pulse and recording echoes thereof; and determining the time delay between echoes of the pulse via a time delay determination process which adjusts the time delay calculation based on the angle of the ultrasound inspection device's ultrasound axis with respect to the nominal surface normal of the front-wall feature.

Abstract: The present invention relates to the detection and analysis of by-products, such as short RNA transcripts, in a process of RNA in vitro transcription by HPLC. It further relates to the use of this method for the quality control of RNA produced by in vitro transcription or for identifying suitable RNA purification conditions.

Abstract: Improved mobile phase buffer compositions, methods, and kits are provided for pH gradient LC-MS characterization of monoclonal antibodies and charge variants thereof.

Abstract: A device for sealing to a chromatographic column includes an insertion body and a tip assembly. The insertion body has an attachment end, a tip opposite to the attachment end and a fluidic channel extending between the attachment end and the tip. An attachment feature located near the attachment end secures the insertion body to an actuator. An axially movable sheath may be provided at the tip to protect the tip assembly prior to and during coupling to a column end nut and to assist in aligning the device to the column end nut. The device can be loaded by manual clamping or by an automated clamp mechanism to achieve sufficient force for a fluid tight seal in the column end nut. Devices are column agnostic and may be used in a column oven to enable a chromatography system to be quickly configured with a wide variety of columns.

Abstract: Embodiments of a gas chromatography system and method are disclosed. The method includes injecting a gas sample into a first gas separation device that includes at least one first hydrocarbon identified for analysis; determining that a concentration level of the first hydrocarbon needs to be reduced; diluting the gas sample with a first amount of a dilutant from a first dilutant mass controller; separating out a subset of chemical species from the first diluted gas sample; injecting the gas sample into a second gas separation device, the sample including at least one second hydrocarbon identified for analysis; determining that a concentration level of the second hydrocarbon needs to be reduced; diluting the gas sample with a second amount of the dilutant from a second dilutant mass flow controller; separating out a subset of chemical species from the second diluted gas sample; analyzing the subsets of the diluted samples.

Abstract: A method of determining a calibration for an analytical instrument comprises ionising a calibrant to produce calibrant ions, performing a sequence of ion separation scans, performing a plurality of mass analysis scans by performing one or more mass analysis scan(s) during each ion separation scan of the sequence, and using data obtained from the plurality of mass analysis scans to determine a calibration for the analytical instrument. Each ion separation scan has a duration TIMS, and each mass analysis scan has a duration TMA. Each ion separation scan has a respective start time ti0, and each mass analysis scan has a respective start time tijMA defined relative to the start time ti0 of the ion separation scan during which the mass analysis scan is performed. The start times tijMA of the plurality of mass analysis scans include start times separated by a delay time ?t, wherein ?t<min (TMA, TIMS).

Abstract: A model function fitting device includes an acquirer that acquires a chromatogram, and a fitter that fits a model function to the chromatogram, while applying, to the model function, a constraint that the model function described by a logarithmic scale has a first portion being approximatable to a quadratic function and second portions being located at both sides of the first portion and being approximatable to a linear function.

Abstract: A method of mass spectrometry is provided. The method comprises performing the following steps for each of a plurality of sub-ranges selected from an overall m/z range: accumulating in an ion store a sample of precursor ions to be analysed, the precursor ions having m/z values within the sub-range; accumulating in the ion store a sample of fragmented precursor ions to be analysed, the fragmented precursor ions being formed from fragmentation of precursor ions having m/z values within the sub-range; and simultaneously analysing the combined samples of the precursor ions and the fragmented precursor ions in a mass analyser.

Abstract: The present invention relates to the use of trigonelline as biomarker for detecting and/or quantifying improvements of the mood disorder status and/or excessive emotional reaction of a subject. It also relates to a method for detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or excessive emotional reaction of a subject, in particular for monitoring the progress of an intervention to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject, wherein the intervention comprises the administration of a probiotic. The method further comprises 4-cresol sulfate as additional biomarker. It also relates to an improved method to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject in need, comprising administering to the subject, an effective amount of a composition combining a probiotic with trigonelline.

Abstract: An apparatus including at least one vanadium oxide-doped laser-induced graphene sensor is disclosed. The sensor is configured to simultaneously monitor and decouple NOX gas emission and soil temperature. The apparatus may be an electronic device including a plurality of electrical components, such as a controller unit that is connected to non-transitory memory or other type of non-transitory computer readable medium and a transceiver unit.

Abstract: Discussed is a gas sensor for detecting volatile organic compounds, the gas sensor including a substrate including a non-conductive material, an electrode located on the substrate and including a conductive material, and a sensing layer configured to be in contact with at least a portion of the electrode or to cover the electrode, the sensing layer reacting to a predetermined gas, wherein the sensing layer includes a compound of SnO2 with an alkali metal oxide or an alkaline earth metal oxide. The sensing layer specifically reacts to formaldehyde among volatile organic compounds. When the sensing layer detects formaldehyde by connecting electrodes to each other, the sensing layer can detect the formaldehyde by checking a change in current in the electrode.

Abstract: Aspects of the disclosure relate to an environment analysis platform for air composition estimation. The environment analysis platform may receive a set of environment information corresponding to an environment from one or more environment information sources. The environment analysis platform may generate an estimated air composition using an environment analysis model. The environment analysis platform may generate a cumulative particle score based on the estimated air composition. The environment analysis platform may determine whether or not the cumulative particle score satisfies a criteria. The criteria may indicate whether the environment is a compliant environment or an outlier environment. The environment analysis platform may send one or more commands directing a user device to display a user interface based on the determination.

Abstract: An apparatus, system, and method for determining a source of contaminants in air. The apparatus includes a plurality of sensors configured to generate raw sampling data of the air. The raw sampling data can describe at least two characteristics of the contaminants in the air. The apparatus also includes memory storing instructions and a processor communicatively coupled to the set of sensors and the memory, the processor configured to execute the instructions to cause the apparatus to identify one or more occurrences of a contamination event based on a comparison of the a characteristic and a detection threshold for the first characteristic of the contaminants in the air; and for each of the one or more occurrences of the contamination event, generate a data entry including a second characteristic. The second characteristic is usable to determine the source of the contaminants in the air.

Abstract: An arrangement includes a gas measuring device (100) and an expansion module (20, 21). A process configures the gas measuring device. The gas measuring device includes a base part (1), a gas sensor, an evaluation unit and a reader (17). The gas sensor measures a detection variable that correlates with the concentration of a target gas. The evaluation unit determines the target gas concentration based on a detection variable measured value. The expansion module is detachably connectable to the base part and has an identifier stored in a data memory (19, 24) of the expansion module. With the expansion module connected to the base part, the reader reads the data memory without contacting the expansion module. Depending on a signal from the reader, the gas measuring device determines whether the expansion module is connected to the base part or not and if connected triggers a procedure.

Abstract: Various embodiments of the present disclosure provide systems and methods for detecting and classifying a disease state of a plant based at least in part on generating a reflectance signature for the plant. The reflectance signature is generated using a reduced set of orthogonal signal components determined from the Karhunen-Loeve Expansion. Various embodiments enable the classification of different disease states (e.g., healthy, asymptomatic, early stage, late stage) of a particular plant disease and the classification of disease states of different plant diseases, such as the differentiation between plants infected with a first plant disease from plants affected with another plant condition. The reflectance signature is generated using reduced-spectrum frequency data extracted or processed from reflectance signal data obtained from the plant.

Abstract: A method for qualifying molasses based on an optical measurement, the method may include: based on reference optical spectra of samples of distinct molasses, associated with respective known molasses qualities, building by machine learning a statistical model of molasses qualities as a function of at least one spectral characteristic of the reference spectra; and for a current optical spectrum of a sample of a current molasses, based on the statistical model, identifying the at least one spectral characteristic of the current optical spectrum and determining a quality of the current molasses, the current molasses quality relating to at least one yeast performance obtained when the yeast is fed with the current molasses.

Abstract: A method for determining odor deterioration and lipid oxidation degree of tilapia during cold storage is provided. Fresh tilapia fillets are collected, cleaned, mixed and minced. A lipid extract is obtained, and divided into multiple lipid samples. The lipid samples are refrigerated for different days and analyzed by a lipidomics technique to obtain lipid oxidation degree and lipid metabolism data. A lipid metabolic network associated with odor is established. The lipid metabolic data is analyzed based on the lipid metabolic network to obtain metabolic markers corresponding to the lipid samples. An evaluation metabolite marker is screened among the metabolic markers. The metabolic status of the lipid samples is analyzed based on the evaluation metabolite marker.

Abstract: A method for extracting a black-odorous water body based on a CART classification model includes: selecting a research region, designing sampling points within the region; monitoring relevant chemical indicators of the water body at various sampling points, extracting remote sensing reflectance data of the water body, determining a type of the water body according to a classification standard of relevant chemical indicators for an urban black-odorous water body; comparing and analyzing the remote sensing reflectance data to obtain spectral change features of the black-odorous water body and a general water body; constructing each node of a decision tree according to the spectral change features and based on Gini index, constructing a decision tree classification model to obtain classification results of the black-odorous water body and the general water body, calculating a classification accuracy; analyzing the classification results to obtain spatiotemporal distribution changes of black-odorous water bodies

Abstract: Systems and methods include a computer-implemented method for identifying fractured reservoir types. Well flow data that is received for a well is measured during flowing bottom hole pressure and surface production rates. A transient analysis of the well is performed using the well flow data and analyzed chemical and physical properties of fluid samples of the well. A pressure derivative function is determined for each of multiple different fractured reservoir types. Pattern recognition and fracture type identification are completed based on the transient analysis of the well and using the pressure derivative functions. Field development and production optimization for the well are completed using the pattern recognition and fracture type identification.

Abstract: A calculation method for service life of concrete in a plateau environment considering protection and restoration effects is provided and includes a construction of a model based on a coupling effect of multi-factors of temperature-humidity-salt concentration-load under the plateau environment, simulation of protection and restoration effects, and quantification of service life. The model includes the physical fields of temperature conduction with variable boundary conditions, water dry-wet cycle transport, salt ion transport, and force fields caused by internal and external loads. The simulation of protection and restoration effects include: surface protective coating, damage restoration, and rebar corrosion resistance.

Abstract: Combining UV and/or visible light, a conveyor, a computer and photodetectors is an efficient and cost-effective way to determine if any reared and breeding insects are sick and/or dead. A pool of insects placed on a conveyor allows sick and/or dead insects that are present in the pool to be detected because they move into a beam of UV and/or visible light, wherein they emit light (e.g., fluorescent light), which can be detected by photodetectors. The computer that may be operationally attached to the UV and/or visible light, the photodetectors, and the conveyor may be able to ascertain an exact position where the one or more sick and/or dead insects is/are.

Abstract: Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C-peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Abstract: A method for studying the behaviour of a cell sample contained in a medium containing a plurality of anisotropically shaped nanoparticles dispersed therein, the method including: (i) determining at least one nanoparticle orientation characteristic in a measurement zone at the interface between the fluid medium and the cell sample, the orientation resulting at least partially from the interaction of the fluid medium and the biological material; (ii) determining a mean shear rate characteristic of the fluid medium in the measurement zone from said at least one nanoparticle orientation characteristic determined in this measurement zone; and (iii) determining a characteristic of the cell sample from the mean shear rate thus determined in the measurement zone.

Abstract: This disclosure describes fluorescence-based sensors for detecting and quantifying ATP, and methods of using such sensors in vitro and in vivo.

Abstract: The present invention provides human striatal-like organoid (hSLO) similar to a huma striatum, a fusion organoid of hSLO and human midbrain-like organoid (hMLO) having functional connections between the hSLO and hMLO, and method of testing drugs using the organoids culture platform.

Abstract: The present disclosure provides a colloidal gold immunochromatographic joint inspection card for diquat and paraquat in the field of on-site rapid detection, as well as a preparation method and application. The joint inspection card includes a PVC base plate, where the PVC base plate is sequentially provided with a sample pad, a gold-labelled pad, a nitrocellulose membrane and a water-absorbing pad along the chromatographic direction; the gold-labelled pad is adsorbed with an antibody solution labeled with paraquat colloidal gold and an antibody solution labeled with diquat colloidal gold; the nitrocellulose membrane is provided with a T1 detection line, a T2 detection line and a quality control line along the chromatographic direction; and an area of the T1 detection line is coated with paraquat complete antigen, an area of the T2 detection line is coated with diquat complete antigen, and the quality control line is coated with goat anti-mouse IgG.

Abstract: The present disclosure provides methods for detecting heavy metals in tissues and cells while identifying cell types at the single-cell level with intracellular or cell surface heavy metal content. The cell type can be identified by contacting the cell with an antibody that binds a biomarker conjugated to a heavy metal that is different from the heavy metal detected in or on the surface of the cell. The methods include detecting heavy metals using mass cytometry.

Abstract: Devices, methods, and kits are provided for isolating a target cell from a fluid sample. In particular, a magnetophoretic separation device is provided that applies varying magnetic field strength to flowing magnetically tagged cells. Immunomagnetic negative selection of target cells is used to maintain target cells in their native, unlabeled state. The magnetophoretic separation device is suitable for isolating cells from low volumes of whole blood, which provides an advantage over in-bulk methods that require larger starting volumes of blood. A computer implemented method is also provided for producing target magnetophoretic profiles along the path through which cells travel through a fluidic conduit in the device that is adaptable to a variety of form factors.

Abstract: A method for magnetically sorting biological objects comprising the steps of providing a fluid sample containing an initial biological mixture that includes magnetically labeled biological objects; depositing a first biological mixture on the conduit wall of a conduit exposed to a magnetic field by flowing the fluid sample through the conduit; rinsing the first biological mixture by flowing a stream of buffer fluid through the conduit and filling the conduit with the buffer fluid; removing the magnetic field from the conduit; resuspending the first biological mixture in the buffer fluid to form a suspension of the first biological mixture by applying mechanical agitation to the conduit; and depositing a second biological mixture on the conduit wall by applying the magnetic field to the suspension of the first biological mixture in the conduit, wherein the second biological mixture has a magnetically labeled biological object purity higher than the first biological mixture.

Abstract: The present disclosure relates to a method of distinguishably detecting two biomarkers with cross-reactivity in a biological sample. The method comprises providing two sensor units specific to the two biomarkers, respectively; obtaining binding affinities of a series of known concentrations of the two biomarkers to the sensor units, respectively; contacting the biological sample with the two sensor units to produce two signals; and calculating the concentrations of the two biomarkers in the biological sample with the two signals and the binding affinities.

Abstract: There is disclosed an electrode including a substrate, a conductive material layer on the substrate, an insulating layer comprising an electrode layer on the conductive material layer, and a groove region in at least a portion of the insulating layer, and the electrode layer is extended into the groove region, and the conductive material layer is exposed to the groove region.

Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-COV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: A device for detecting a target analyte in a sample includes a nanowell impedance sensor configured to receive a sample including a target analyte. An impedance between electrodes of the sensor is modulated by the target analyte when present in the sample, the modulated impedance being indicative of a concentration of the target analyte in the sample. A receiver circuit, connected across the electrodes, has a receiver resonance frequency and includes an inductive coil to induce an electrical current in the receiver circuit while inductively coupled with a physically separate transmitter circuit having a transmitter resonance frequency. The receiver resonance frequency is within a resonance overlap percentage of the transmitter resonance frequency. The electrical current induced in the receiver circuit is a time-varying signal having a frequency within a signal overlap percentage of the receiver resonance frequency.

Abstract: In one aspect, a method of detecting tetrahydrocannabinol (THC) in a sample is disclosed, which comprises bringing the sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to THC, applying a time-varying electric field to said antibody-functionalized graphene layer, monitoring electrical resistance of said graphene layer in response to interaction with said sample, and detecting presence of THC in the sample by detecting a change in said electrical resistance indicative of interaction of THC with said anti-body functionalized graphene layer.

Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.

Abstract: An exemplary embodiment of the present disclosure provides a system for detecting biomarkers. The system can comprise a composition a first electrode, a second electrode, and an electrical property sensor in electrical communication with the first electrode and the second electrode. The electrical property sensor can be configured to measure an electrical property of the composition. The composition can comprise a molecule of interest configured to bind with a target molecule in a biological sample, a probe molecule configured to bind with the target molecule, and a first metal particle configured to bind with the probe molecule.

Abstract: The present invention relates to a method of identifying, optionally using molecular docking and/or in vitro assays, a compound which binds to tristetraprolin (TTP), preferably a compound which inhibits phosphorylation of TTP. Furthermore, the present invention relates to a method of preventing or treating a disease in a patient having an increased level of phosphorylated TTP. The present invention also relates to a compound for use in a method of preventing or treating a disease in a patient having an increased level of phosphorylated TTP.

Abstract: This invention is directed to compositions and methods to detect and treat gastrointestinal diseases.

Abstract: Disclosed herein are systems and methods for determining ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof in a blood sample obtained from a subject. Also disclosed herein are systems and methods for determining CK-MB, ?-hCG, thyroid stimulating hormone (TSH), homocysteine, free thyroxine (free T4) or any combinations thereof in a blood sample.

Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.

Abstract: The present invention relates to the identification of biomarkers which are associated with a higher risk of advanced colorectal Neoplasia (ACN), for example colorectal cancer (CRC), in a subject. The detection and measurement of these biomarkers in a biological sample may be used to inform the clinician as to whether further invasive procedures including colonoscopy or sigmoidoscopy are required to provide a definitive diagnosis of colorectal cancer in the subject.

Abstract: The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for evaluating and predicting lung cancer risk. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to estimate or determine lung cancer risk. In another aspect, methods are provided for evaluating and predicting lung cancer risk in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 6.

Abstract: A method for detecting the amount of CDH17 protein in a sample from Automated Tissue Staining a subject, the method comprising: contacting the sample with a buffer at a temperature of at least 98° C. to provide a treated sample, contacting the treated sample with a capture antibody having a binding affinity to CDH17, wherein any exposed CDH17 expressing epitope in the treated sample is configured to bind to the capture antibody to provide a bound sample, contacting the bound sample with a detection molecule to provide a detection sample, wherein the detection molecule comprises a biocompatible enzyme conjugated to a secondary antibody having a binding affinity to the capture antibody, reacting the detection sample with a 3,3?Diamonobenzidine chromogen to provide an oxidized substrate, and determining the amount of CDH17 protein in the sample based on the amount of oxidized substrate.

Abstract: Methods of treating resectable head and neck cancer based on analyses of blood and tumor samples collected over the course of a clinical trial and during follow-up after the clinical trial. Omic or multi-plex molecular tools were used to analyze the tissues and identify objective molecular markers and pathogenic mechanisms associated with favorable or unfavorable outcomes. These analyses form the basis for a treatment strategy that improves outcomes by tailoring the treatment to the molecular features of individual patients' blood samples and tumors. This method for personalized treatment distinguishes between subjects who respond to neoadjuvant anti-PD-1/L1 therapy and patients who do not respond to such neoadjuvant therapy, so that treatment is tailored to the subject's responder profile. This approach avoids exposing patients to unnecessary toxicity, and avoids delaying surgical resection when no advantage will be gained by delaying surgery to allow for neoadjuvant therapy.

Abstract: The present invention relates to a method of evaluating the sensitivity or resistance of a cancer cell to an antitumoral therapeutic treatment. It further relates to the treatment of a cancer with an inhibitor of the eiF4F complex used for the sensitisation of said cancer to an antitumoral therapeutic treatment.