Abstract: A sleep induction device includes a headband, multiple transcranial stimulation electrodes, and control electronics to drive the electrodes. The sleep induction device may be worn by an awake user prior to attempting sleep. The control electronics are configured to cause the stimulation electrodes to emit a sequence of stimulation waveforms separated by interstimulus periods. The stimulation waveforms may have the characteristics of low-delta waveforms that may characterize non-REM stage 3 sleep. The stimulation period may last from about 4-8 seconds and the interstimulus period may last from about 10 to 30 seconds. A sleep induction session may include multiple alternating stimulation and non-stimulation periods. The sleep induction session may last for about 5 minutes to about 30 minutes.

Abstract: A quality assurance apparatus for a cancer treatment system with an electric field, comprising: an electric field generator configured to transmit an electric field to an inside of an electromagnetic phantom through an electrode array attached to the electromagnetic phantom; a measurement unit configured to measure any one of a voltage, a current, and an electric field inside the electromagnetic phantom; a data collection unit configured to collect a value measured by the measurement unit and convert the measured value into a digital value; an analysis unit configured to calculate and monitor a distribution and intensity of the electric field inside the electromagnetic phantom through the value transmitted from the data collection unit; and a verification unit configured to verify the electric field monitored by the analysis unit.

Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.

Abstract: The present disclosure relates to connectors for high density neural interfaces and methods of microfabricating the connectors. Particularly, aspects of the present disclosure are directed to a connector having a main body, a first plug extending from the main body, a flexible bridge extending from the main body or the first plug, and a second plug extending from the flexible bridge. This structure allows for the main body, the first plug, and the second plug to be arranged in tandem on a longitudinal axis of the main body, which enables the connector to be passed through a narrow diameter cannula. This structure also allows for the first plug and the second plug to be arranged in a spread out orientation, which enables the connector to be electrically connected with a neurostimulator.

Abstract: Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG.

Abstract: A method includes receiving first information regarding a pose of a structure in a first time period. The structure is configured to be inserted into a body portion of a recipient. The first information includes at least one of: a first estimate of the pose of the structure in the first time period, and a first measurement set including one or more first measurement values. At least some of the one or more first measurement values are generated using a plurality of sensors distributed along the structure. The one or more first measurement values are indicative of the pose of the structure in the first time period. The method further includes generating a second estimate of the pose of the structure using at least the first information and a probabilistic model of the structure and/or the body portion.

Abstract: The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing.

Abstract: Methods and systems for positioning a leadless pacing device (LPD) in cardiac tissue are disclosed. A delivery device is employed that comprises a proximal end, a distal end and a lumen therebetween sized to receive the LPD. The LPD has a leadlet extending therefrom that includes a means to fixate the leadlet to tissue. The delivery device comprises an introducer to introduce the LPD into the lumen of the delivery device. The LPD is loaded in the distal end of the lumen of the delivery device. The leadlet extends proximally from the LPD while the fixation means extends distally toward the LPD. A LPD mover is configured to advance the LPD out of the delivery device. A leadlet mover is configured to advance the leadlet out of the lumen delivery device and cause the leadlet to engage with cardiac tissue.

Abstract: Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include a proximal section including a deflection mechanism for deflecting the proximal section, and a distal holding section extending distally of a distal end of the proximal section and defining a cavity therein for receiving an implantable leadless pacing device. The distal holding section may be structured to have portions that flex and bend while allowing the implantable device to be recaptured within the distal holding section.

Abstract: An electrical stimulation system includes a sheath that includes conductive points that are operative to facilitate electrical stimulation to a bodily portion of a user. Drive-sense circuits (DSCs) generate electrical stimulation signals based on reference signals and provide those electrical stimulation signals via electrodes to the conductive points of the sheath. The electrical stimulation signal is coupled into respective locations of the bodily portion of the user that are in proximity to or in contact with the conductive points of the sheath. In addition, the DSCs sense, via the conductive points of the sheath and via the electrodes, changes of the electrical stimulation signals based on coupling of them into the respective locations of the bodily portion of the user. The DSCs provide digital signals that are representative of the changes of the electrical stimulation signals to one or more processing modules that includes and/or is coupled to memory.

Abstract: A method of treating cancer is disclosed. The method involves applying one or more direct current electric fields (DC-EFs) to a subject and administering to the subject an additional treatment selected from the group consisting of radiation, an effective amount of one or more chemotherapy agents, SapC-DOPS, anti-phosphatidylserine targeted drugs, and combinations thereof.

Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.

Abstract: Provided is an electrotherapy device suitably used in electroporation method, and specifically configured to inject medicine and the like into deep inside of the body. The electrotherapy device has an outer shaft having a lumen and extending in a distal-proximal direction; an inner shaft disposed in the lumen of the outer shaft; a needle tube fixed to the inner shaft; and at least one linear conductor having at least one electrode needle fixed to the inner shaft and having at least one conductive line connected to a proximal part of the electrode needle, the needle tube and the electrode needle configured to project or retract from a distal part of the outer shaft.

Abstract: A medical device is configured to deliver therapeutic electrical stimulation pulses by generating frequency modulated electrical stimulation pulse signals. The medical device includes a pulse signal source and a modulator. The pulse signal source generates an electrical stimulation pulse signal having a pulse width. The modulator may include a high frequency modulator configured to modulate a frequency of the pulse signal from a starting frequency down to a minimum frequency during the pulse width. The modulator may include a low frequency bias generator to modulate the offset of the pulse signal between a minimum offset and a maximum offset in other examples.

Abstract: A mobility augmentation system assists a user's movement by determining a corresponding electrical stimulation for the movement. A wearable stimulation array includes sensors, electrodes, an electrode multiplexer, and a controller that executes the mobility augmentation system. The sensors measure movement data, and the mobility augmentation system applies a movement model to the measured movement data. The model can determine different electrical actuation instructions depending on the movement stimulated. For example, to stimulate a knee flexion, the movement model output enables a first set of the electrodes to operate as cathodes and a second set of electrodes to operate as anodes. To stimulate a knee extension, the first set of electrodes can be enabled to operate as anodes and a third set of electrodes as cathodes. The user can provide feedback of the applied stimulation, which the system can use to retrain the model and optimize the stimulation to the user.

Abstract: A method of implanting includes inserting a stimulation element into a head-and-neck region and positioning an electrode array of the stimulation element relative to a target portion of a nerve.

Abstract: A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Abstract: A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal. The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain.

Abstract: Methods and devices are provided for the non-invasive treatment of diseases or disorders, such as Alzheimer's disease, Parkinson's disease, rheumatoid arthritis (RA), multiple sclerosis, postoperative cognitive dysfunction, or postoperative delirium. A method for comprises positioning an electrode in contact with an outer skin surface of a neck of the patient and transmitting, via the electrode, an electric current transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient. The electrical impulse comprises bursts of 2 to 20 pulses with each of the bursts comprising a frequency from about 15 Hz to about 50 Hz and with each of the pulses comprising a duration from about 20 microseconds to about 1000 microseconds.

Abstract: A system is provided that includes a medical device comprising a power supply, a signal generator and an electrode. The signal generator is configured to apply one or more electrical impulses to the electrode for a period of time defined as a single dose. The system further comprises a processor coupled to the medical device. The processor is configured to switch the medical device from an activated mode to a deactivated mode after a specific number of single doses have been applied by the signal generator.

Abstract: Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and/or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and/or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

Abstract: This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient including user indicated activities inputted from an icon driven user interface of an external patient controller device.

Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Abstract: This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.

Abstract: Ventricle-from-atrium (VfA) cardiac therapy may utilize a tissue-piercing electrode implanted in the left ventricular myocardium of the patient's heart from the right atrium through the right atrial endocardium and central fibrous body. The exemplary devices and methods may determine whether the tissue-piercing electrode is achieving effective left ventricular capture. Additionally, one or more pacing parameters, or paced settings, may be adjusted in view of the effective left ventricular capture determination.

Abstract: An implantable medical device may include a plurality of electrical components connected to form operational circuitry, a canister shaped for housing the operational circuitry, and a dampening layer configured to reduce internal motion between the operational circuitry and at least one of a plurality of additional component within the canister, the dampening layer selectively disposed over the operational circuitry but not over the at least one additional component, the dampening layer providing electrical isolation to the operational circuitry, the dampening layer comprising a moldable material in direct contact with an inner surface of the canister. Methods of manufacturing such a medical device are also disclosed.

Abstract: Disclosed are a timeline-based navigation feature and a channel selection feature. The timeline-based navigation feature allows the user to visually identify significant events during an episode and quickly navigate the display of data to those significant events. Embodiments of such feature allow a user to quickly see that there is a shock delivered, for example, and click on that part of a timeline navigator to advance the detailed display of data to that point in the episode. The data channel selection feature enables selection of display channel(s) from among a set of available data channels. Embodiments of such feature enable a selection and/or deselection of various channels for display to minimize display of extraneous data and/or to select preferred channels of data for review.

Abstract: In biological tissues, exposure to electromagnetic fields usually induces actuation and vibration of the underlying molecules which, from the perspective of the electromagnetic device, manifests as power absorption. It has been shown that increased power absorption of a low-power RF source can have positive enhancement in therapeutic, medical, and scientific procedures. However, often the enhanced power absorption is limited due to the electromagnetic properties of the tissue being treated. This invention introduces a method to modify the native electromagnetic properties of a targeted biological tissue to increase and enhance the electromagnetic power absorption within and increase treatment efficacy.

Abstract: A method of treating dysautonomia in a human via transcranial magnetic stimulation is provided. The method includes positioning an induction device in proximity to a head region adjacent a prefrontal cortical brain region of the human and delivering magnetic stimulation to the prefrontal cortical region of the human by applying current to the induction device at a frequency that promotes inhibition (e.g., a frequency of about 5 Hertz or less, or certain types of theta bursts). The transcranial magnetic stimulation can introduce variability and/or have a modulatory or a disinhibitory effect on an autonomic nervous system of the human. For instance, the transcranial magnetic stimulation can increase a level of heart rate variability in the human by having a positive modulatory effect on the autonomic nervous system in which autonomic balance is achieved or restored as a result of the stimulation.

Abstract: Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with a remote server for patient monitoring, prescription and/or device servicing.

Abstract: According to some embodiments, a system for fractionally treating tissue includes: an electromagnetic radiation (EMR) source configured to generate an EMR beam having a transverse ring energy profile; an optic configured to converge the EMR beam to a focal region located within a tissue; and, a window assembly located down-beam from the optic configured to cool the tissue when placed in contact with an outer surface of the tissue.

Abstract: According to an embodiment of the present disclosure, a light outputting device for scalp care includes a dome-shaped outer case defining an appearance, an inner case formed inside the outer case, and a plurality of light sources disposed in a space between the outer case and the inner case, wherein the plurality of light sources include a plurality of first laser light sources, and the optical outputting device includes a plurality of light guide mechanisms arranged corresponding to the plurality of first laser light sources to distribute laser light emitted from the first laser light sources apply the laser light toward the inner case.

Abstract: A light source and a method of generating a light using the light source is disclosed. The light source is configured to produce a plurality of distinct colors in generating the light, one of the distinct colors falling within a blue spectral light band. A light controller modulates the spectral light produced by the plurality of distinct colors. The modulation provides melanopsin contrast in order to increase melanopsin responsiveness of a subject exposed to the generated light and maintains the color temperature, color quality, and color constancy experienced by the subject in a lit viewing environment within an acceptable range.

Abstract: Methods and systems for performing optogenetics using X-rays or ultrasound waves are provided. Visible-light-emitting nanophosphors can be provided to a sample, and X-ray stimulation can be used to stimulate the nanophosphors to emit visible light. Alternatively, ultrasonic waves can be provided to the sample to cause sonoluminescence, also resulting in emission of visible light, and this can be aided by the use of a chemiluminescent agent present in the sample. The emitted light can trigger changes in proteins that modulate membrane potentials in neuronal cells.

Abstract: A radiotherapy system and a therapy plan generation method therefor. The radiotherapy system includes a beam irradiation apparatus, a therapy plan module, and a control module. The beam irradiation apparatus generates a beam for therapy and irradiates an irradiated body to form an irradiated part. A tissue model template library of the irradiated body is stored in the therapy plan module; the therapy plan module performs dosage simulation calculation according to the tissue model template library, medical imaging data of the irradiated part, and a parameter of the beam for therapy generated by the beam irradiation apparatus, and generates a therapy plan. The control module retrieves, from the therapy plan module, the therapy plan corresponding to the irradiated body, and controls the beam irradiation apparatus to irradiate the irradiated body according to the therapy plan determined by the therapy plan generation method.

Abstract: According to one embodiment, an irradiation control apparatus includes processing circuitry. The processing circuitry obtains an MR image of a first time phase, which includes a tumor region of a patient. The processing circuitry estimates a position of the tumor region of the patient of a second time phase from the MR image of the first time phase, the second time phase being a predetermined time phase after the first time phase. The processing circuitry controls irradiation by a radiotherapy apparatus based on the estimated tumor position of the second time phase.

Abstract: Disclosed herein is a method of positioning a patient for radiotherapy treatment using a radiotherapy system. The method comprises determining a first target position for the patient for radiotherapy treatment; implementing a spatial relationship between the patient and at least a part of the radiotherapy device, at a first time (t1), according to the first target position; providing radiotherapy treatment to the patient; determining a current position of the patient, at a second, subsequent time (t2); and determining whether a change of a spatial relationship between the patient and at least a part of the radiotherapy device should be made, according to the first target position.

Abstract: Disclosed are a method and an apparatus for controlling multileaf collimator in radiotherapy. The method comprises: acquiring a preset model; outputting, regarding a radiotherapy target, a target leaf sequence of a multileaf collimator through the preset model, to obtain a planning file; and importing the planning file into a radiotherapy planning system to control a linear accelerator to operate, so as to implement a radiotherapy plan, which solves the technical problem in the related art of poor accuracy and stability in determining a leaf sequence of a multileaf collimator.

Abstract: Systems and methods for a pre-treatment quality assurance (QA) of a radiotherapy device may be provided. The method may include determining a measured dose image through an electronic portal dose imaging device (EPID). The method may include determining an energy fluence distribution map related to radiation beams predicted by a first portal dose prediction model. The method may include determining a predicted dose image based on the energy fluence distribution map and a simulated energy response curve related to the EPID. The method may further include determining differences between the measured and predicted dose images by comparing the dose distributions of the measured and predicted dose images.

Abstract: A rotating gantry and radiotherapy equipment are provided. The rotating gantry includes a fixed support frame, a bearing, a roller, and at least two support components, a bearing outer ring of the bearing is connected to the fixed support frame, a bearing inner ring of the bearing is connected to one end of the roller, and the support components support the roller and roll relatively to the roller. Therefore, an embodiment of the present disclosure adopts a dual support of the support components and the bearing, improves a support rigidity and rotation accuracy of the roller, and makes efficient and accurate treatment possible. The rotating gantry in an embodiment of the present disclosure has an integral structure with small axial space, may easily pass through a narrow hospital labyrinth, is flexible in transportation and convenient in installation.

Abstract: The present disclosure provides a system for functional ultrasound imaging, where the system comprises: a) an apparatus for delivering a nucleic acid encoding a mechanosensitive ion channel to a target neural cell population in a region of a brain; and b) a functional ultrasound imaging device. The present disclosure provides a method for functional ultrasound imaging.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: Body-worn air-treatment devices include a body that is configured to be selectively coupled proximate to a respiratory tract inlet of a living individual, and a pathogen-deactivating mechanism that is supported by the body. Methods include deactivating pathogens proximate to a respiratory tract inlet of a living individual.

Abstract: A wearable respiratory isolation system is configured as an open collar to be worn loosely around the neck of the user, with an articulating arm positioning a mouthpiece in front of the mouth and nasal region of the user. The system provides filtered and sterilized air through a inhalation vent on the mouthpiece which creates a curtain of sterilized air in front of the users face, which protects the users face from air bourne pathogens provides sterile air for the user to inhale. Exhaled air is extracted through an exhalation vent on the mouthpiece, is decontaminated and exhausted to the rear of the user. A modified, background oriented Schlieren imaging technique is used to determine whether the user is inhaling or exhaling, and this information is used to control the flow of sterilized air and the capture of exhaled gases.

Abstract: An exercise machine is disclosed. The exercise machine comprises a motor, an actuator, a vertically pivotable arm, and a cable. A position of the vertically pivotable arm is able to be locked at least in part by using a component including one or more teeth. The vertically pivotable arm includes a release component. The cable is coupled between the actuator and the motor through the vertically pivotable arm. The motor facilitates strength training at least in part by generating resistance such that a force on the actuator corresponds to a specified weight.

Abstract: An adjustable lower body fitness device attaches to the user's foot using a body attachment portion and includes an integrated and adjustable weight portion that can be set to a desired weight by adding or subtracting weight increments. Once a user attaches the adjustable lower body fitness device to the user's foot using a body attachment portion, the entire adjustable lower body fitness device becomes an extension of the user's leg that allows users to effectively and efficiently exercise their lower body and core while also providing flexibility, minimal floor space/storage requirements, simplicity, relatively low cost, and minimal maintenance requirements.

Abstract: A system for use in personal fitness can include: an article of clothing configured to be worn by a user during a personal fitness session, the article of clothing having a fabric layer and at least one weighted portion formed by either or both polyurethane (PU) and thermoplastic polyurethane (TPU) printed on the fabric layer; an electronic device having a processor; and a communication unit integrated with the article of clothing and configured to interact with the electronic device, wherein the communication unit includes a near field communication (NFC) device or a QR code, and further wherein the processor is configured to launch a personal fitness application responsive to the user interacting with the NFC device or QR code.

Abstract: A fitness exercise apparatus includes a main frame, a seat unit, a resistance unit, a transmission unit, and an operating unit. The main frame includes a base seat and a support unit. The seat unit is mounted on the base seat. The resistance unit includes a weight subunit that is mounted on the main frame, and an elastic subunit that is connected between the weight subunit and the main frame. The transmission unit includes a first fixed pulley set, two second fixed pulley sets, two third fixed pulley sets, a first movable pulley, a movable pulley set, two second movable pulleys, a first cable, two second cables, and a third cable. The operating unit includes at least one operating member that is connected to one of the first and second cables.

Abstract: A protective rowing device for compression of the abdomen is provided that comprises a brace and U-shaped support member that may connect to a rowing machine seat and rail.

Abstract: Disclosed in the present disclosure is an arm exercise machine, including an upper arm assembly, a forearm assembly and a damping-adjustable hydraulic cylinder, where the upper arm assembly is used for being sleeved on an upper arm, the forearm assembly is used for being sleeved on a forearm, a lower end of the upper arm assembly is rotatably connected to a rear end of the forearm assembly, a cylinder body of the hydraulic cylinder is mounted on a side surface of the forearm assembly, and an end of a piston rod is connected to the upper arm assembly. At least one strap for fixing each of the upper arm assembly and the forearm assembly on an arm is provided on each of the upper arm assembly and the forearm assembly. The present disclosure can be convenient to carry, and can adjust exercise strength without the risk of injuries.