Abstract: An indicating device suitable for indicating the number of dosages of a substance that have been dispensed from or remain in a container includes at least one first indicator member incrementally moveable to a plurality of positions and a second indicator member moveable in response to a predetermined number of movements of the at least one first indicator member. The at least one first indicator member includes primary dosage indicia adapted to indicate the number of dosages of substance that have been dispensed from or remain in the container. The second indicator member includes secondary dosage indicia adapted to indicate that less than a minimum predetermined number of dosages of substance remain in the container. In one preferred embodiment, the primary dosage indicia are configured as numerical indicia and the secondary dosage indicia are configured as color indicia.

Abstract: A Breath Actuated Inhaler having a canister with a medication dispensed when compressing the canister. Compression of the canister is prevented by a mechanism only allowing compression when an air flow is sufficient to ensure dispensing of the medication in the lungs/throat of the person. No latch or blocking mechanism is provided so that any force exerted by the person is, at all times, directed to the canister or preventing mechanism so that when no force is exerted by the user, no force is exerted in the inhaler. Prolonged exertion of such force could otherwise cause dimension changes and subsequent uncertainty of the dose size.

Abstract: A dose counter for use in connection with a device adapted for metered dispensing of a medication is described. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

Abstract: A inhaler for an inhalation formulation, comprising a canister containing a pharmaceutical composition under pressure; a metering valve for measuring a metered dose of the composition from the canister for administration to a patient in need thereof; and an actuator for actuating discharge of the metered dose to the patient; wherein the actuator includes a discharge orifice having a diameter in the range 0.2 to 0.4 mm; and wherein the pharmaceutical composition comprises an anticholinergic agent and a pharmaceutically acceptable propellant.

Abstract: A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: An inhalation device for administering one or more sedatives via pulmonary delivery for treating a sleep disturbance.

Abstract: A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit (20, 24) including a nosepiece (17) for fitting to a nostril of a subject and a nozzle (45) through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit (43, 49, 51) for delivering substance through the nozzle of the nosepiece.

Abstract: A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device.

Abstract: An actuator for attachment to an inhaler of the type including a pressurized canister of medicine, the actuator comprising a sensor for detecting the presence of a patient to whom medicine is to be delivered from the pressurized canister; and the actuator comprising an electrically driven mechanical linear motion to trigger a lever which is moveable between an at rest position and an in use position in which the lever exerts a force on the canister so as to operate the inhaler and thereby release medicine from the pressurized canister to provide ease of use of the inhaler for patients with reduced or limited dexterity and grip/co-ordination. The actuator device can provide data logging using non-volatile internal memory; the data being capable of being downloaded via physical interface or Bluetooth.

Abstract: A device for use in an aerosol inhalation system for delivering aerosolized medication includes a housing that is operatively connected to a source of aerosolized medication such that the aerosolized medication is delivered to the housing. The device also includes a patient interface member removably connected to the housing and being separate therefrom. The patient interface member is in the form of a face mask for placement about a face of the patient and in communication with a mouth of the patient for delivering the aerosolized medication. The patient interface member incorporates an integral inhalation valve and safety feature for protecting against displacement of the inhaltation valve.

Abstract: A bag-on-valve aerosol container includes a chamber, where a pressurized gas is contained, surrounding a flexible bag, and where a closable outlet is in fluid communication with the flexible bag. The flexible bag includes a leave-on dermatological composition having an oil-in-water emulsion, comprising one or more oils, the emulsion having an oil phase to water phase ratio of between 1:1 and 1:25; one or more oil-in-water emulsifiers; and one or more active dermatological ingredients. The leave-on dermatological composition has a viscosity at room temperature of between 1 and 20,000 mPa·s. The product compartment further includes one or more physical foaming agents having a standard boiling point of ?50 to 70° C.

Abstract: Inhaler device (10) comprising an actuator body (20) and an inhaler canister assembly (70), the inhaler canister assembly (70) is comprised of a canister (30) with a metering valve at a valve end and a dose counter unit (60) attached to a base end thereof. Further, the inhaler canister assembly (70) comprises first position ensuring means (110, 230), the actuator body comprises second position ensuring means (120,210), wherein the first and second position ensuring means being complementary mating means, and the first and second position ensuring means being so arranged that the inhaler device (10) cannot be fired, nor the counter unit (60) count unless the first and second position ensuring means are in a mating relationship. There is also provided an inhaler canister assembly (70) and an actuator body (20).

Abstract: The invention relates to an aerosol therapy device comprising a membrane nebulizer (1) and a personal digital assistant (PDA (2)), which are interconnected via communication devices (10, 11) in such a way that therapy data, which has been prepared in relation to signals, is transmitted from the membrane nebulizer (1) to the PDA and control data is transmitted from the latter (2) to the membrane nebulizer (1).

Abstract: The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.

Abstract: This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction.

Abstract: A dust cap for a pMDI having a cap part adapted for a push-fit on the dispensing nozzle of the pMDI and a strap part for connecting the dust cap to the pMDI, wherein the cap part is slidably mounted on the strap part for sliding movement between an extended position and a contracted position.

Abstract: A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions.

Abstract: A dispensing device for dispensing metered dosages of a medicament from a container includes a dispenser housing having a support block defining a longitudinal axis and an indicator housing disposed at least partially around the support block. An actuator includes a central, cylindrical hub portion adapted to be engaged by the container and centered about the longitudinal axis. The actuator is moveable along the longitudinal axis relative to the indicator housing and includes a resilient arm. A drive gear is rotatably disposed in the indicator housing and is rotatable in response to successive engagements by the resilient arm. An indicator is rotatably disposed in the indicator housing and is rotatable in response to the rotation of the drive gear. The indicator includes dosage indicia. A dispensing system and indicating device are also disclosed.

Abstract: A patient interface system for delivering a gas to a patient includes a patient interface device that includes at least one inhalation valve and at least one exhalation valve. The system also includes a venturi device that has at least one port for connection to a gas source. The venturi device has at least one primary air entrainment window and at least one secondary air entrainment window which is downstream of the at least one primary air entrainment window. The inhalation valve is disposed between: (1) the main body and (2) the primary and secondary air entrainment windows of the venturi device. At least one of the primary air entrainment window and secondary air entrainment window includes a means for closing the respective window, thereby changing a degree at which the respective window is open and changing a flow rate of the air flowing through the respective window.

Abstract: The invention relates to a medical hand-held device, in particular an atomizer (1), for dispensing a liquid pharmaceutical preparation from a container. The pharmaceutical preparation can be based, for example, on an alcoholic solvent. The proposed atomizer has a discharge nozzle for the pharmaceutical preparation. Located upstream from the discharge nozzle (12d, 12e) there is a multiple-stage filter system, which is composed of at least three filtering components (27, 28, 12f). The filters differ from one another in terms of their filter threshold and their filter materials and/or filter effect. In particular, the use of a filter made of sintered metal is proposed in order to avoid penetration of particles into a microstructured component (12), which can also contain a very fine filter in front of the nozzle. Alternatively or in addition, it is also proposed to use an adsorption filter in the flow path between a coarse filter and the microstructured component.

Abstract: A portable, handheld breath-actuated inhaler comprises a generally cylindrical body that comprises body portions 1, 3 that receive a canister 2 of pressured fluid such a nicotine to be inhaled in an aerosol by a user, a mouthpiece 7 in the first body portion 1 configured to deliver an amount of the aerosol to the mouth of the user from the canister. A trigger is cocked ready for releasing pressurized fluid from the canister by manually sliding the body portions 1, 3 towards one another. The trigger comprises a compression spring 26 and a cam 33 which engages a pressure sensitive puff lever 28 with a plate 29 that releases the cocked trigger when a user sucks on the mouthpiece and draws in air through air inlet opening 26. Release of the trigger releases spring 26 which slides the body portions apart and also opens a valve in the canister so as to deliver the aerosol to the mouthpiece.

Abstract: A valved holding chamber (2) includes a main chamber housing (49 and a mouthpiece assembly (6) removeably coupled to a first end of the main chamber housing, the mouthpiece assembly including a mouthpiece housing (24) having a mouthpiece portion (32) and a valve housing portion (30), a retaining ring (28) provided within and coupled to the valve housing portion, and a one-way inhalation valve (26) having an annular valve seat member (52), wherein the valve seat member is held between the retaining ring and an engagement surface of the valve housing portion. In one particular embodiment, a portion of the first end of the main chamber housing engages the bottom of the valve seat member and creates a seal between the main chamber housing and the one-way inhalation valve and between the one -way inhalation valve and the mouthpiece housing.

Abstract: An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor (10) in an aerosol output pathway of the system. A controller (600) determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

Abstract: This invention relates to a solution formulation for nasal administration comprising azelastine, beclomethasone dipropionate, a co-solvent, an acid and an HFA propellant.

Abstract: The invention relates to a hand-held device (1), as depicted in exemplary FIG. 4, for metered dispensing of sprayable substances, particularly medicaments for inhalation, with a cartridge (3) that can be moved into the dispensing position, by pressure being applied to a housing, and with a step-by-step indexing mechanism (11) which is entrained by the cartridge (3) in the opening travel thereof and which is used to record and display the dispensing actuations that have been performed.

Abstract: The present invention provides an improved metered dose inhaler utilizing the property of the aerosol canister. The metered dose inhaler includes: a housing body (2); an aerosol canister (3) including a canister body (3a), a valve stem (3b), and a spring urging the valve stem, wherein the valve stem (3b) is held at a fixed position inside the housing body (2), and wherein the canister body (3a) is supported inside the housing body (2) to be depressible against a spring force of the spring; a dose counter (10) including display members (12) and (13) rotatably supported inside the housing body (2), and a control lever (14) swingably supported inside the housing body (2) to rotate the display member (13); and a control cap (20) including a junction member rotatably joined to the control lever (14), and a cap portion (20b) which sheaths the canister body (3a) from a bottom side of the canister body (3a), wherein the control cap (20) causes the control lever (14) to swing.

Abstract: A pharmaceutical aerosol composition comprising at least one hydrofluoroalkane propellant; at least one active agent complexed with an adjuvant; and, optionally, at least one pharmaceutically acceptable excipient.

Abstract: A compliance monitor (20) is attachable to or forms part of a drug delivery device, such as an inhaler (2). The monitor comprises a flexible portion (38) to enable a switch which is actuated by a user when delivering a dose of medicament. The monitor further comprises a sensor for sensing whether the device is properly positioned in contact with or relative to the user's body for administration of the medicament. For example, where the device is an inhaler and the sensor a temperature sensor, temperature variations caused by insertion of an inhaler mouthpiece into the user's mouth indicate whether the dose has been delivered into the patient's mouth. A memory in the compliance monitor stores a compliance record indicating whether or not the device was properly positioned each time a dose was delivered.

Abstract: A dose counting device for use with a medicinal metered dose dispensing device, the device including an actuator having at least one finger that is designed for reciprocal movement comprising an outward stroke and a return stroke, an annular member having a helical thread segment formed about a circumferential arc on a part of its surface, and a drive nut positioned around a radial cross-section of the annular member and having an internal helical rib engaged with said helical thread segment on the annular member whereby rotation of the drive nut about the circumferential arc of the annular member results in rotational movement of the annular member, the outer surface of the drive nut comprising one or more driving surfaces for engagement by said at least one finger on the actuator during said reciprocal movement to cause rotation of the drive nut.

Abstract: A device for removing a mass lodged in a choking victim's throat comprises a manifold, piston, spool, and latch. The manifold has first, second, and third conduits in selective fluid communication with each other, with the second conduit terminating in an orifice in a mouthpiece. The spool, having a transverse orifice, may be disposed in the third conduit, slidable between a first position where the orifice permits fluid communication between the first and second conduits, and a second position where the spool blocks fluid communication. The piston is slidably disposed within the first conduit, and with the spool is in the second position, the latch is usable to secure the piston relative to the manifold at one or more discrete positions to create a measured amount of vacuum pressure in the first conduit. The vacuum pressure is transmitted to the mouthpiece by movement of the spool to said first position.

Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom; and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece; wherein the main body is provided with an outlet opening for receiving the outlet assembly in a position wherein the mouthpiece extends outside the outlet opening and the nozzle block is inserted through the outlet opening and arranged in position for receiving the valve stem of the canister. There is also disclosed an inhaler comprising the above-described actuator and a canister containing medicament, a main body and an outlet assembly.

Abstract: A discharge head 10 (in illustrated embodiments) for discharging droplets from discharge ports can withstand high water pressure and is provided with a first orifice plate 3 having first discharge ports 3a and a second orifice plate 6 having second discharge ports. The first orifice plate 3 and the second orifice plate 6 are separated from each other in the liquid discharge direction of the discharge head 10 and disposed opposite to each other. The diameter of the discharge ports of the second orifice plate 6 is smaller than the diameter of the discharge ports 3a of the first orifice plate 3 so that very fine droplets 9 are discharged from the discharge head 10 as the liquid discharged from the discharge ports 3a of the first orifice plate 3 is split by the second discharge ports.

Abstract: A pharmaceutical composition and method for the treatment of asthma or other respiratory disease by inhalation from a pressurized metered dose inhaler (pMDI), a dry powder inhaler (DPI) or nebulizer, the composition and method being based on a combination of a short acting beta agonist (SABA) and an inhaled corticosteroid (ICS) in a form adapted to be delivered for inhalation from the pMDI, DPI or nebulizer.

Abstract: A fluid dispenser device including a body (10); a reservoir (20) containing fluid; a dispenser member (30), such as a pump or a valve, for dispensing the fluid contained in the reservoir (20) through a dispenser orifice (45); and a cap (50) that is adapted to cover said dispenser orifice (45) in a closed position. The cap (50) is pivotally mounted on the body (10) to turn about an axis (A) between the closed position and an actuation position, the cap (50) including an actuator mechanism (55; 56, 57) adapted to actuate the dispenser member (30) directly, while the cap (50) is turning towards its actuation position.

Abstract: A process for filling a canister for an inhaler is provided. The canister may be filled with components of a medicament. The canister may be suitable for use in a pressurised metered dose inhaler, such as a breath-actuate inhaler. The process may include sealing the canister with air at ambient conditions. A filling device may dispense a pressurised liquid or gas into the sealed, air-filled canister through a metering valve. The pressurised liquid or gas may comprise at least a propellant. While pressure-filled canisters were previously purged with propellant immediately before sealing to remove the air, the present process may exclude the purging step.

Abstract: Dispensing apparatus for delivering metered doses of product from a pressurized dispensing container, having a housing for receiving, in use, the pressurized dispensing container, and an outlet through which, in use, metered doses of product from the pressurized dispensing container can be dispensed. The housing has an aperture via which the pressurized dispensing container can be inserted into the housing. The dispensing apparatus is at least partially enclosed by a shrink wrapped film, the shrink wrapped film including an opening which is: (a) at least partly aligned with the aperture of the housing; and (b) dimensioned so as to allow, in use, said pressurized dispensing container to pass through the opening in order to be inserted into the housing via the aperture.

Abstract: Pharmaceutical pressurized metered dose inhalers are disclosed having improved temperature and moisture stability comprising CFC-free, ethanol-free compositions that include lactose of particle diameter larger than 1 ?m as a means of minimizing sticking to the walls and other destabilization mechanisms activated by moisture ingress from the environment.

Abstract: A fluid dispenser device comprising: a reservoir (1) of fluid to be dispensed; a dispenser member (2), such as a pump or a valve, mounted on said reservoir (1); and a body (3) that is suitable for receiving said reservoir (1), said body (3) being provided with a dispenser orifice and with an opening (310) via which said reservoir (1) can be inserted into the body (3), said reservoir (1) being displaceable between a working position, in which said dispenser member (2) co-operates with said body (3) between a rest position and a dispensing position, and a withdrawn position in which said dispenser member (2) does not co-operate with said body (3), said reservoir (1) being secured to said body (3) in all positions.

Abstract: Pharmaceutical formulations and methods of using thereof for the treatment and prevention of pulmonary arterial hypertension are provided. The formulations contain one or more agents to simultaneously reduce ADMA levels in a patient and reduce inflammatory processes in the pulmonary vasculature of a patient. The formulations contain a therapeutically effective amount of cerivastatin, a cerivastatin analog, or a pharmaceutically acceptable salt, prodrug, clathrate, or solvate thereof in a carrier suitable for pulmonary administration.

Abstract: The invention relates to improvements in or relating to medicament delivery devices. In particular, this invention relates to a communications device which may be fitted to an electronic medicament delivery device. The invention may be particularly suitable for use with electronic medicament inhalers such as those used for the treatment of diabetes, or respiratory diseases such as asthma, COPD, cystic fibrosis, and bronchiectasis.

Abstract: The present invention is directed to devices, systems, and methods for monitoring inhaled drug usage to predict when an acute attack or exacerbation of a disease, such as a respiratory disease, is imminent. Instrumented inhalers that use modular designs with standard components are disclosed, as are systems for monitoring the instrumented inhalers. Also disclosed are methods for determining whether or not a patient's inhaled drug usage pattern indicates that an acute attack or disease exacerbation is imminent, and notifying appropriate medical personnel of any usage patterns indicative of an attack or disease exacerbation. If such an attack or exacerbation is imminent, additional therapeutic agents may be dispensed to the patient or other interventions made.

Abstract: The present invention relates to metered dose inhaler devices for the administration of medicament to patients for inhalation therapy. Particularly, it discloses a metered dose inhaler device for improving medicament compliance by patients.

Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.

Abstract: A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions.

Abstract: The dispenser has a body (1), with a mouthpiece cover (2). Opening of the cover urges a junction member (3) towards a source (4) of a medicament to be released as a dose by pressing a spout (5) of the source inwards of the source. The source is supported by a cap (11) clipped to the end of a source-enclosing barrel (12) with intern al splines (10). The barrel is welded (15) to the main to part (16) of the body at a position determined by the extension of the source towards the distal end (17) of the barrel when the cover is open, the welding position being determined by a plug (18) simulating the cap and its bush.

Abstract: A pharmaceutical combination comprising (a) a combination of two or more bronchodilators; or (b) a combination of at least one bronchodilator in combination with at least one corticosteroid.