Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.

Abstract: A device for dosed administration of a sprayable substance, in particular aerosols, with an electronic unit for recording the administrations. The device includes a first housing part that forms a seat for a container, which contains the sprayable substance and has a valve. The device also includes a second housing part, which is movable relative to the first housing part and has an actuating part for acting on the valve to actuate the valve for administration of the sprayable substance. The electronic unit records the administrations of the sprayable substance and includes a switch that is actuated by the relative movement of first and second housing parts.

Abstract: An inhaler device having an air canister with a nozzle aperture and a nozzle shaft, the nozzle shaft has a first and second end, the first end is external to the canister and the second end protrudes into the canister, wherein a lip is at the second end, a gasket sandwiched between the nozzle aperture and shaft, a gasket extension extending downwardly, a spray orifice in the shaft at the first end, an external ventilation hole in the shaft external to the canister, an internal ventilation hole in the shaft, and an air channel in the nozzle shaft fluidly connected to each spray orifice, external and internal ventilation hole, wherein the nozzle shaft can move between an open and closed position, the nozzle shaft is biased in the closed position.

Abstract: An administration method for a medical spray inhaler and the medical spray inhaler, which utilizes an inhaling sensing unit to sense an air flow change for generating an inhaling signal after a user inhales by an inhaler body. A control unit is then used to receive the inhaling signal and calculate a delay time. After the delay time, the control unit outputs a control instruction to control a medicine container disposed on the inhaler body to spray a medical spray and concurrently records the ventilation volume per inhalation of the user.

Abstract: Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.

Abstract: A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

Abstract: Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.

Abstract: A system of medicament dispensers includes a plurality of dispenser housings each having a unique first indicia and a plurality of containers each having a unique second indicia. The unique second indicia of each of the containers corresponds to one of the unique first indicia of a corresponding one of the dispenser housings. Methods for associating various containers and dispensers is also provided.

Abstract: In a press-type medical nebulizer and a pressing means thereof, the nebulizer includes a medicament container having an intake channel and a medical spray generator. The pressing means includes a base, a pressing element and a switching element. The base has a gas-delivering tube, a gas-releasing hole and a trough. The pressing element comprises an operating arm pivotally connected into the trough and a valve for closing the gas-releasing hole. The switching element is slidingly provided on the operating arm to be selectively engaged into the trough for fixing the operating arm. When the switching element is engaged into the trough, the switching element causes the valve to close the gas-releasing hole, so that the pressurized gas can continuously flow through the gas-delivering tube and enter the intake channel. By this arrangement, the user needs not to press the pressing means repeatedly, which is convenient and labor-saving.

Abstract: This invention relates to an inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.

Abstract: An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.

Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.

Abstract: A system and method for dispensing metered doses of medicament to a subject that monitors one or more aspects of the dispensation. The medicament is aerosolized for dispensation to the subject so that the subject can inhale the medicament into his airway. The one or more aspects of the dispensation that are monitored based on ultrasonic energy generated by the aerosolization of the medicament. The one or more aspects of the dispensation that are monitored may include one or more of a number of doses dispensed, a number of doses remaining, whether any medicament remains to be dispensed, and/or other aspects of the dispensation of the medicament.

Abstract: Aerosolized dapsone (or alternatively, an aqueous formulation of dapsone) is used to treat airway inflammation, particularly chronic neutrophil-dominated inflammation. Diseases that may be prevented or treated by the methods include chronic obstructive pulmonary diseases (COPDs), asthma, cystic fibrosis, and others.

Abstract: An aerosol generator comprising a body, a mouthpiece on the body and a delivery mechanism delivers aerosol for inhalation by a consumer into the mouthpiece by turning the mouthpiece and body relative to one another. The aerosol is generated from liquid dispensed from a canister having a discharge tube depressible inwardly to open an interior valve. A nozzle member is driven inwardly against the discharge tube of the canister when the mouthpiece and body are turned relative to one another, to open the valve and create the aerosol.

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

Abstract: A dispensing device for dispensing metered dosages of a medicament from a container includes an indicator housing having an interior and an opening communicating with the interior. A first actuator is disposed within the interior and includes a resilient arm member defining a pawl portion. The first actuator is reciprocally moveable between an actuated position and an at-rest position. A spring is disposed in the indicator housing and biases the first actuator towards the at-rest position. A ratchet gear is rotatably disposed in the indicator housing, and is rotatable in response to the movement of the first actuator between the actuated and at-rest positions. An indicator is rotatably disposed in the indicator housing and is rotatable in response to the rotation of the ratchet gear. A second actuator is shaped to be received through the opening in the indicator housing. The second actuator and indicator housing are moveable relative to each other between first and second positions.

Abstract: The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, clemastine, diphenhydramine, digoxin, levothyroxine, cyclosporine, ondansetron, lysine, zolpidem, propofol, nitenpyram, ivermectin, milbemycin, and pharmaceutically acceptable salts, solvates and esters thereof. In another embodiment, the invention includes methods of treating or preventing a condition in an animal comprising transmucosally administering a composition comprising a therapeutically or prophylactically effective amount of an active agent and a pharmaceutically acceptable carrier.

Abstract: An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises a dose counting mechanism comprising a counter. The inhaler further comprises a dispensing mechanism, the dispensing mechanism being configured, on actuation, to dispense a dose of medicament and to adjust the counter. The inhaler further comprises a resetting member configured for movement in a first direction between a first position and a second position to reset the dispensing mechanism, and a prevention mechanism comprising a pair of first and second engaging members. If the movement of the resetting member in the first direction is reversed before it reaches the second position, the first and second engaging members prevent further actuation of the dispensing mechanism until the resetting member is again moved in the first direction. At least one of the first and second engaging members is configured to resiliently flex, under load, into abutment with a substantially rigid component of the inhaler.

Abstract: A respiratory treatment device having an inlet configured to receive exhaled air into the device and an outlet configured to permit exhaled air to exit the device. A blocking member is moveable between a closed position where the flow of air through the device is restricted, and an open position where the flow of air through the device is less restricted. A biasing member is configured to bias the blocking member toward the closed position, wherein a level of bias decreases as the blocking member moves from the closed position to the open position.

Abstract: An inhaler, such as a breath-actuated metered-dose inhaler, for delivering medicament to a patient. The inhaler includes a housing for holding the medicament and having an air inlet and a medicament delivery port which together define an air flow path into which the medicament is dispensed. The air inlet includes an array of elongate apertures formed in the housing, the long sides of adjacent apertures facing each other. Each aperture is provided with a respective different opening in an outer surface of the housing. The opening of each aperture extends in two different planes such that, if at least a part of the opening is covered in one of the two different planes during inhalation by the patient, a void space is created between the cover and the aperture so as to provide an air flow path through the void space to the at least one aperture.

Abstract: This invention relates to a pressurised metered dose inhaler comprising a canister, wherein the canister contains a formulation comprising a tiotropium salt and an HFA propellant, wherein the inhaler is an inhalation-actuated inhaler.

Abstract: Aerosol formulations comprising glycopyrronium chloride in combination with formoterol may be administered by means of a pressurized metered dose inhaler (pMDI) for the prevention or treatment of chronic obstructive pulmonary disease. The formulation further comprises a HFA propellant, a co-solvent, and an amount of inorganic acid sufficient to stabilize both the glycopyrronium chloride and the formoterol components. Optionally, the formulation may further comprise beclometasone dipropionate.

Abstract: The present invention relates to the field of mechanical-ventilation devices, in particular devices that enable drugs to be fed into the airflow, generated by the ventilation device and directed to the respiratory pathways of a patient, using an aerosol dosing device and/or nebulizer. Specifically, the invention relates to an inhalation chamber (1) to be built into a circuit of a mechanical-ventilation respiratory device (100) through which a gas stream is to pass, said inhalation chamber (1) consisting of two portions on either side of the longitudinal axis (A) thereof, and comprising openings that lead into the inner space (Vi) thereof, wherein two openings (10, 11) are to be connected to the circuit of the respirator, i.e.

Abstract: A drug delivery apparatus includes a mouthpiece portion having an internal conduit for delivering an aerosol including the drug to the patient. The internal conduit has an inlet end and a mouthpiece end that is structured to be received in the patient's mouth. The mouthpiece portion is structured to operate at a substantially fixed inhalation flow rate when the patient inhales through the mouthpiece end. The apparatus further includes an aerosol generator for generating the aerosol from a drug supply and injecting the aerosol into a first region within the mouthpiece portion located between an outlet of the aerosol generator and the inlet end of the conduit. The mouthpiece portion also includes a flow accelerating mechanism that causes a localized flow rate at the first region to be greater than the inhalation flow rate. A method is also provided that increases the local flow rate within the mouthpiece portion.

Abstract: An inhaler (1) for dispensing doses of medicament from a container under user activation includes a body (7) which includes a mouthpiece (5) through which the medicament is dispensed and a cap (2) which can be place in a position to substantially occlude the mouthpiece (5). The cap (2) is attached to the body (7) by a strap (3) which pivots from the body (7), the cap (2) being arranged to slide on the strap (3) such that the cap (2) must translate away from the mouthpiece (5) prior to the pivoting of the strap (3).

Abstract: A ventilator assembly includes a housing defining an inhalation interior space and an exhalation interior space separate from the inhalation interior space. A ventilator port is positioned at a first location of the housing and defines a first passageway in communication with the inhalation interior space and the exhalation interior space. A patient port is positioned at a second location of the housing and defines a second passageway in communication with the inhalation interior space and the exhalation interior space. A one-way inhalation valve permits one-way flow from the ventilator port to the patient port through the inhalation interior space and a one-way exhalation valve permits one-way flow from the patient port to the ventilator port through the exhalation interior space. A receptacle is in communication with the inhalation interior space and is operative to receive a container comprising an aerosolized medication.

Abstract: An intruder detection system including a light emitting unit, a light guide, and a light receiving unit. The light emitting unit is arranged to emit light into the light guide and the light guide is arranged to guide the light to the light receiving unit. The impact of an intruder on the light guide causes changes in the characteristics of the light received at the light receiving unit.

Abstract: A metered dose inhaler (“MDI”) applicator is disclosed that includes a carrier, a housing, an adjuster and a lever. The carrier defines an aperture configured to receive a boot of a MDI. The housing is configured to be assembled with the carrier and to move in a vertical direction within the MID applicator relative to the carrier. The adjuster is configured to move between a locked position and an unlocked position, wherein when the adjuster is in the locked position, the adjuster is configured to prevent the carrier and the housing from moving in one or more directions relative to one another. The lever is pivotally connected to the housing and is configured to transfer a force applied to the lever to a canister of the MDI and to actuate the MDI to dispense an aerosolized medicine.

Abstract: An indicating device includes a housing having a longitudinally extending cavity shaped to receive the container and an indicator member disposed in the cavity and having a longitudinally extending wall shaped to surround at least a portion of the container. The indicator member is rotatably mounted within the housing and is rotatable relative thereto about a longitudinal axis. The indicator member includes a driven gear. A drive gear is disposed in the housing and includes a drive portion selectively engaged with the driven gear. An actuator is adapted to move with the container and is selectively engaged with the drive gear.

Abstract: The present invention relates to a dispenser cap arrangement for enclosing a portion of a dispenser of a medicament. In particular, the present invention relates to a dispenser cap arrangement, a dispenser cap a dispenser cap closure device, a method of closing a dispenser, and a closure arrangement.

Abstract: A delivery device includes a toroidal shaped housing defining an interior chamber and a central open space. The housing includes an input port communicating with the interior chamber and a delivery port positioned on an inner periphery of the housing. The delivery port is in fluid communication between the interior chamber and the central open space. The delivery port is spaced from the input port, which is adapted to receive an aerosolized medicament. In another aspect, a kit includes an outer ring-like housing component and a plurality of differently configured inner ring-like housing components mateable with the outer ring-like housing to form a holding chamber. A method of delivering an inhalable substance includes positioning a nose and a mouth of a user in a central opening defined by a ring-like housing, inhaling through the nose, and orally soothing the user with a soothing device located in the central opening.

Abstract: The disclosure describes an aerosolizer with (i) means sized for intranasal or paranasal insertion that produces an aerosol from a material for delivery in close proximity to the upper airways, and (ii) the material comprising one or more proinflammatory cytokine inhibitor(s).

Abstract: According to the invention there is provided a method of treating a component of a medicament dispenser device, the component having one or more surfaces which come into contact with the medicament during storage or use of the device, the method including the steps of: providing said component; and coating at least one of said surfaces by plasma deposition thereby to inhibit surface deposition or degradation of the medicament, wherein at least part of the plasma deposition is performed under DC bias control.

Abstract: A method and system for optimizing the dispensing of aerosol medicaments by “pulsing” a total dose volume as a series of shorter, low volume bursts is described. Aerosol performance when metering at a low volume e.g. <10 ?L is enhanced by an increase in the fine particle fraction, particularly when pulsing a dose to achieve a high total dose volume. By utilising a solenoid valve, the system can deliver a medicament in a single low volume pulse; or in multiple low volume pulses. Performance can be tailored to obtain a preferred fine particle dose and fraction. By manipulating the solenoid valve timings, a single formulation with a concentration X may be used to provide a range of doses. A minimum interval between pulses to achieve separate “non-interacting” plumes which allow keeping total inhalation time comparable to a conventional single dose MDI actuation is also described.

Abstract: An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patient's lungs.

Abstract: A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterized in that it exhibits a low effective flow rate of less than about 5 liters per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

Abstract: The present invention relates to dispensers, in particular to dispensers for dispensing a dose of a gaseous, gas borne or droplet substance from a substance source and dispensers comprising dosage counters.

Abstract: A surfactant-free pharmaceutical composition is described. The composition consists essentially of: (a) a drug component consisting of salbutamol sulphate; and (b) a propellant component consisting essentially of 1,1-difluoroethane (R-152a). A method for preparing the pharmaceutical composition is also described. The pharmaceutical composition can be delivered using a metered dose inhaler (MDI).

Abstract: A detachable cap is disclosed for an inhaler apparatus having an inhaler housing and a canister configured to hold a first substance that is aerosolized on demand from the user. The apparatus' canister is engaged with the inhaler housing to convey the aerosolized first substance into the user's mouth via a mouthpiece. The detachable cap includes a cap body having a first end and a second end. The detachable cap also includes an actuation surface arranged at the first end, wherein the actuation surface is configured to be depressed by the user to actuate the canister and aerosolize the first substance. The detachable cap additionally includes a feature arranged at the second end and configured to be engaged with at least one of the inhaler housing and the canister to secure the detachable cap to the inhaler apparatus. An inhaler apparatus having such a detachable cap is also disclosed.

Abstract: A detachable mouthpiece for an inhaler apparatus constructed to convey an aerosolized substance into a user's lungs via the user's mouth. The detachable mouthpiece includes a detachable mouthpiece body having a first distal end defining a first opening and a second distal end. The detachable mouthpiece also includes a feature positioned at the second distal end of the detachable mouthpiece body. The feature is configured to selectively attach the detachable mouthpiece at the second distal end to and detach the detachable mouthpiece from a housing of the inhaler apparatus. The first opening is configured to convey the aerosolized substance from the inhaler apparatus to the user's mouth when the detachable mouthpiece is secured to the housing of the inhaler apparatus. An inhaler apparatus having such a detachable mouthpiece is also disclosed.

Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.

Abstract: One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer element to move the transfer element from a

Abstract: A pharmaceutical composition is described that is suitable for delivery from a pressurised container. The composition is free of polar excipients and comprises: (a) a propellant component that consists essentially of 1,1-difluoroethane (R-152a); (b) a surfactant component that comprises oleic acid; and (c) a drug component that consists of salbutamol sulphate. The pharmaceutical composition can be delivered using a metered dose inhaler (MDI).

Abstract: Medicinal inhalation devices and components having a non-metal coating and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating are provided. In some embodiments, the partially fluorinated compound comprises a polyfluoropolyether silane of Formula Ia: Rf[Q-[C(R)2—Si(Y)3-x(R1a)x]y]z??Ia wherein: Rf is a monovalent or multivalent polyfluoropolyether segment; Q is an organic divalent or trivalent linking group; each R is independently hydrogen or a C1-4 alkyl group; each Y is independently a hydrolysable group; R1a is a C1-8 alkyl or phenyl group; x is 0 or 1 or 2; y is 1 or 2; and z is 1, 2, 3, or 4. Methods of making the devices and components are also provided.

Abstract: Devices and methods are disclosed for monitoring a patient's compliance with an asthma inhaler treatment regimen. The device may monitor an inhaler's motion to determine whether the motion is characteristic of typical inhaler use. Additionally, the device may monitor a temperature of the inhaler or in proximity to the mouthpiece to determine whether a patient has used the inhaler. The devices and methods may incorporate a smart phone application that provides notifications and alerts to aid in compliance with the asthma medication regimen.

Abstract: The disclosure relates to an Breath actuated inhaler (BAI) actuator, comprising: a loading element capable of being loaded with an actuation force, a breath actuated trigger mechanism arranged to counteract the actuation force of the loading element, and to fire the actuator by releasing the actuation force of the loading element in response to an inhalation breath, and actuation locking device moveable between a locked position wherein it relieves the actuation force from the trigger mechanism setting the trigger mechanism in a neutral position, and an armed position wherein the trigger mechanism is set in an armed position.

Abstract: A metered dose inhaler with an electronic dose counter, and method of operating and forming the same. In one embodiment, the metered dose inhaler includes a pressurized canister assembly formed with a memory device affixed thereto. The metered dose inhaler also includes a canister housing into which the pressurized canister assembly is inserted, the canister housing formed with an electronic dose counter including a display configured to display a dose count of a drug in the pressurized canister assembly stored in the memory device.

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

Abstract: An apparatus and method for performing positive pressure (PP) therapy alone or in combination with an aerosol delivery apparatus. The positive pressure apparatus includes a positive pressure valve having a continuously variable respiratory window. The PP valve may be associated with a patient respiratory system interface alone, such as, but not limited to, a mask or mouthpiece, or in combination with an aerosol delivery apparatus.