Abstract: An inhaler for inhaling medicament includes a body for retaining a medicament store and a dose counter. The dose counter has a moveable actuator and a chassis mounted on the body. The chassis is heat staked in position on the body.

Abstract: A dose counter for an inhaler, the dose counter having a display tape arranged to be incrementally driven from a tape stock bobbin onto an incremental tape take-up drive shaft, the bobbin having an internal bore supported by and for rotation about a support shaft, at least one of the bore and support shaft having a protrusion which is resiliently biased into frictional engagement with the other of the bore and support shaft with longitudinally extending mutual frictional interaction.

Abstract: A nebulizer includes an insertable container and a counter device for counting operations of the nebulizer. The nebulizer can be opened for replacing the container. The counter devices blocks opening of the nebulizer until a predetermined number for operations has been reached.

Abstract: A cannabinoid material as active agent containing formulation comprising the active agent, an HFA propellant, and optionally a co-solvent is disclosed. Also disclosed is an inhalation method of administration of the formulation without the use of heat greater than 50° C.

Abstract: A device atomizes or vaporizes a liquid for inhalation. A housing has a proximal exit orifice that communicates with an intake orifice. A housing encompasses a reservoir containing a liquid. A wick has a first end in contact with the liquid and a second end that is exposed at an opening in the reservoir. A heater is disposed within housing in an air passage that communicates between the intake orifice and the proximal exit orifice. An actuator responds to a user of the device by placing the heater and the second end of the wick into proximity with the heater to vaporize the liquid.

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating diseases of the respiratory tract.

Abstract: A system of medicament dispensers includes a plurality of dispenser housings each having a unique first indicia and a plurality of containers each having a unique second indicia. The unique second indicia of each of the containers corresponds to one of the unique first indicia of a corresponding one of the dispenser housings. Methods for associating various containers and dispensers is also provided.

Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.

Abstract: An indicating device for a dispenser that dispenses metered dosages of a medicament from a container having a valve moveable between a closed position and an open position. The indicating device includes an indicator housing having a first cover with a first vertical wall and a second cover with a second vertical wall. One of the first or second covers includes a base defining a lower surface of the indicator housing, and the other of the first or second covers includes a top defining an upper surface of the indicator housing. The first and second covers are joined with the first and second vertical walls and the base and the top defining an interior space therebetween. An indicator is rotatably disposed in the interior space of the indicator housing, with the indicator including dosage indicia. A dispensing device includes a dispenser housing and an indicating device.

Abstract: A medicated inhalant dispenser has a plastics material body having a mouthpiece. A pressurized, inhalant source has a canister and a sprout which his moved towards the canister for release of a dose from the canister. The sprout is accommodated in a junction member, which is movable by a cam connected to a pivotal cover for the mouthpiece. Opening of the cover sets a breath actuable kink valve, having a nozzle through which the inhalant is released and a breath flap actuation. Opening also causes the junction member to be lifted for dose dispensing into the kink valve. Breathing in releases the dose for inhalation. A closed sleeve is provided for abutment of the end of the canister as the junction member is moved towards the canister. Between the canister end and an end of the closed sleeve, an adjustable abutment is provided.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: A system and method for accurately and reliably determining and recording the time, date and location where a medication is used, and a system and method for transmitting, collecting, and using that data to improve clinical care, disease management, and public health surveillance. The device allows information concerning drug usage, including the time, date and location of use, to be transmitted to a remote network computer system so that the data can be evaluated to determine current impairment and future risk, and to identify changes in the frequency, timing, or location of medication usage indicative of change in disease control or management, and to examine spatial, temporal or demographic patterns of medication use or absence of use among individuals and groups. In addition, the device may further be configured to transmit signals indicative of its status, condition or other results to the remote network computer system.

Abstract: An assembly for flushing a dispenser that internally mixes a first composition and a second composition; dispensers including the assemblies are also provided.

Abstract: The present disclosure concerns a counting mechanism for a drug delivery device, comprising a first counting member comprising an interaction element, a second counting member comprising engagement elements that are configured to engage with the interaction element of the first counting member, and a separating member, wherein the first counting member is moveable relative to the separating member between a first and a second relative position, and the separating member is configured to prevent an engagement of the interaction element with the engagement elements when the first counting member is in the second relative position with respect to the separating member. Further, the present disclosure concerns a drug delivery device comprising said counting mechanism.

Abstract: A device for monitoring patient usage of a medicament inhaler, the medicament inhaler being adapted to deliver doses of medicament, and the medicament inhaler including parts which move during the dispensing of a dose of medicament. The device includes a housing, for releasable attachable to the medicament inhaler, and an optical dose counter, associated with said housing, the optical dose counter being adapted to determine when a dose of medicament has been dispensed by transmitting optical signals through the medicament inhaler. The device is attachable to the medicament inhaler, and is subsequently operable, without any modifications being required to be marks to the medicament inhaler. The device may also include an electronic control module which is in communication with the optical dose counter, the electronic control module being adapted to monitor and/or store data relating to patient usage of the medicament inhaler.

Abstract: A ventilator circuit for use in administering medication to a patient includes a housing, a one-way inhalation valve and a one-way exhalation valve. A metered does inhaler receptacle is in fluid flow communication with an interior space of the housing holding chamber. An exhaust conduit communicates between input and output passageways disposed on opposite sides of the interior space.

Abstract: A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

Abstract: Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

Abstract: The invention relates to a trigger mechanism for a drug delivery device comprising at least one energy storing element, an actuation element and a series of cascaded trigger elements. The trigger elements are pre-stressed with increasing pre-stressing and coupled to the at least one energy storing element such that the trigger elements, upon exerting a sufficient actuation force (Fa, U) on the actuation element, cause a cascaded release of increasing portions of energy stored in the at least one energy storing device. At least one of the trigger elements is equipped with a latch element directly coupling at least two trigger elements such that the latch element restrains at least one of these trigger elements to its pre-stressed state before exerting the actuation force (Fa, U).

Abstract: The present invention provides an adapter for fitting to a drug delivery device, the adapter comprising: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of the drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. The present invention also provides a drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.

Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.

Abstract: The invention relates a metering device for fluids from a containment volume. The metering device is a means to dispense metered volumes of fluids such as detergents, medicaments, lotions and the like. The invention further provides a container for fluid material to be dispensed in metered doses.

Abstract: An electronic cigarette case with a thermometer comprises a case body for accommodating at least one electronic cigarette. The case body further comprises a thermometer device disposed therein. The thermometer device comprises a thermometry unit, a display unit and a circuit processing unit. The thermometry unit detects temperatures of articles to be tested or media to be tested and transmits temperature data to the circuit processing unit for controlling the display unit to display measured temperatures. The thermometry unit comprises a temperature sensor and an electrode piece. The thermometry unit comprises a temperature sensor and an electrode piece. The temperature sensor is disposed at an outside of the case body and is electrically connected with the circuit processing unit via the electrode piece. The electronic cigarette case of the present invention is capable of detecting temperatures of human bodies, other objects or media such as surroundings.

Abstract: There is provided a drug dispenser device comprising a housing defining a first chamber; extending from said housing and defining a second open chamber, an outlet for insertion into a body cavity of a patient; provided to said first chamber of the housing, a discharge block defining a discharge block orifice; receivable within the first chamber for movement therewithin, a drug discharge device, said drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from said container, wherein said discharge channel is receivable by said discharge block to enable discharge of said drug formulation via said discharge block orifice to said outlet; provided to the housing; and at least one finger operable member moveable to apply a force directly or indirectly to the drug discharge device for movement along the longitudinal axis towards the discharge block to actuate said discharge mechanism.

Abstract: An inhaler device (1) contains, or is capable of accepting, a plurality of doses of a medicament to be dispensed from the inhaler (1). To ameliorate the problem of double dosing from the inhaler (1), the device further comprises prevention means (26, 28, 40) for preventing, at least temporarily, the dispensing of a dose of medicament, and detection means (32) for detecting the inhalation of a previously dispensed dose of medicament. When the detection means (32) detects the inhalation of the previously dispensed dose of medicament, it releases the prevention means (26, 28, 40), allowing the device to dispense a further dose of medicament. The detection means (32) may be a pressure sensor, and the prevention means (26, 28, 40) may operate by causing a disengagement of an actuation mechanism.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.

Abstract: A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal cavity of a subject and comprising an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject; and a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.

Abstract: Disclosed is a medicine box counter, which comprise a case body, comprising a bottom seat, an upper cap movably combined with the case body, and a plurality of resilient elements disposed between the bottom seat and the upper cap. As such, the medicine and the bottom seat are directly combined so that when the user exerts a pressure upon the upper cap in the use course, the resilient elements may be indirectly extruded and thus the bottom seat triggers the count mechanism to count, and after the pressure on the upper cap is released, the upper cap automatically restores to its original position by means of the resilient elements, whereby achieving the efficacies of rapid assembly, convenient use, effective medicine-taken count and reduced manufacturing cost are provided.

Abstract: In a modular medicament delivery system, a dispenser housing has a support block with a well and an orifice communicating with the well. A first container assembly includes a valve stem shaped to be received by the well in the support block. The first container assembly has a first exterior shape. A second container assembly includes a valve stem shaped to be received by the well in the support block. The second container assembly has a second exterior shape that is different than the first exterior shape. An insert member is adapted for mounting to the dispenser housing in the cavity and defines an interior space shaped to receive the second exterior shape of the second container. Methods of assembling the system, a system kit and a device are also provided. A medication delivery device includes first and second end pieces and a collapsible chamber disposed therebetween.

Abstract: A system for providing automated delivery of medication to a ventilator circuit that extends between a mechanical ventilator and a patient includes a connector that resides in-line with a portion of the ventilator circuit, a portable medication delivery unit attached to the connector, and a control device in communication with the portable delivery unit. The portable delivery unit includes a housing releasably holding at least one metered dose inhaler canister containing medication and an actuator held by the housing and in communication with the canister to direct the canister to release medication to the ventilator circuit for the patient. The control device is configured to control an amount and/or frequency of medication delivery from the canister to the ventilator circuit for a respective patient and to direct the actuator to actuate to deliver the medication from the canister to the ventilator circuit at a defined amount and/or frequency.

Abstract: A mouthpiece (150A) has an aerosol lead-out flow passage (104), an aerosol lead-out opening (105), and exhalation discharge openings (106). The lead-out flow passage (104) includes a first flow passage (104A) extending upward, a second flow passage (104B) extending obliquely forward from the first flow passage (104A), and a corner flow passage (104C) for connecting the first flow passage (104A) and second flow passage (104B) of the lead-out flow passage (104). The mouthpiece (150A) has a curvature portion (153) formed by curving that portion of the first flow passage (104A) wall surface which crosses the center line of the first flow passage (104A). The exhalation discharge openings (106) are provided in a wall surface defining the second flow passage (104B), at a position circumferentially displaced from the wall surface portion at which the curvature portion (153) is provided.

Abstract: A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

Abstract: A medicament dispensing device for dispensing metered dosages of a medicament includes an actuator housing having a longitudinally extending cavity and a container disposed in the cavity and having a cylinder with a first outer diameter. The cylinder is adapted to hold the medicament. The container is reciprocally moveable relative to the actuator housing along a longitudinal axis. An indicating device includes an indicator housing having a tubular portion connected to said container, with the indicating device being reciprocally moveable with the container relative to the actuator housing. The tubular portion has a second outer diameter that is of substantially the same diameter as the first outer diameter. A longitudinally extending side wall has a viewing window formed therein. An indicator is rotatably mounted in the indicator housing, with a surface thereof having indicia visible through the viewing window.

Abstract: An inhalation device for administering one or more sedatives via pulmonary inhalation for treating a sleep disturbance.

Abstract: A surfactant-free pharmaceutical composition is described. The composition consists essentially of: (a) a drug component consisting of salbutamol sulphate; and (b) a propellant component consisting essentially of 1,1-difluoroethane (R-152a). A method for preparing the pharmaceutical composition is also described. The pharmaceutical composition can be delivered using a metered dose inhaler (MDI).

Abstract: Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

Abstract: The present disclosure provides a universal breathing tube adaptor that can accept or otherwise accommodate a metered dose canister (MDC) having a variety of shapes, structures, sizes, and/or configurations. The present breathing tube adaptor includes a sidewall which defines a chamber. A conduit extends from the chamber through a floor of the device for discharging aerosolized medicament from the MDC. The sidewall includes opposing exposed edges which define a channel. The sidewall supports the MDC when it is invertingly inserted into the chamber. The channel permits structure of an MDC to extend radially outward through the channel and outside the chamber thereby enabling the valve stem of the MDC to engage the conduit.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.

Abstract: Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of the nanoparticles contact adjacent nanoparticles, the nanoparticles comprise an active ingredient, and the nanocluster has a mass median aerodynamic diameter of from about 0.25 ?m to about 20 ?m.

Abstract: The present disclosure relates to a metered dose dispensing valve for dispensing metered volumes of an aerosol formulation from an aerosol container. The valves described herein are particularly suitable for use with metered dose inhalers for the oral delivery of medicaments. By combining the compliant biasing member and the second valve body into an integral single component it is possible to provide a desirable metered dose dispensing valve for use in inhalation devices or for use in the provision of canisters targeted for use in inhalation devices.

Abstract: An adapter for use in a breathing circuit including a housing with a conduit having a ventilator port adapted to be coupled to a breathing circuit and a patient port adapted to communicate with a patient interface. A medicament container receptacle communicates with the conduit between the ventilator port and the patient port. The receptacle includes a support block having a well shaped to receive a valve stem extending from a container of medicament and an actuator finger extending upwardly in the receptacle adjacent the support block. The actuator finger is adapted to actuate a dose counter coupled to the container.

Abstract: Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract: Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

Abstract: The present invention relates to an Breath actuated inhaler (BAI) actuator, comprising: a loading element capable of being loaded with an actuation force, a breath actuated trigger mechanism arranged to counteract the actuation force of the loading element, and to fire the actuator by releasing the actuation force of the loading element in response to an inhalation breath, and actuation locking means moveable between a locked position wherein it relieves the actuation force from the trigger mechanism setting the trigger mechanism in a neutral position, and an armed position wherein the trigger mechanism is set in an armed position.

Abstract: An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Abstract: A nebulizer includes an insertable container and a securing mechanism for holding the container in the nebulizer such that the container can move back and forth but cannot be separated. The securing mechanism is formed by a metal unitary part. The securing mechanism forms a transportation lock for holding the container unmovable in the housing in a delivery state of the nebulizer. The securing mechanism forms a cage which encompasses the container.

Abstract: Amino acid sequences are provided that are directed against/and or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.

Abstract: The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.