Abstract: An ultrasound apparatus capable of mixing and/or atomizing fluids is disclosed. The apparatus includes a horn having an internal chamber through which fluids to be atomized and/or mixed flow. Connected to the horn's proximal end, a transducer powered by a generator induces ultrasonic vibrations within the horn. Traveling down the horn from the transducer, the ultrasonic vibrations induce the release of ultrasonic energy into the fluids to be atomized and/or mixed as they travel through the horn's internal chamber. As the ultrasonic vibrations travel through the chamber, the fluids within the chamber are agitated and/or begin to cavitate, thereby mixing the fluids. Upon reaching the front wall of the chamber, the ultrasonic vibrations are reflected back into the chamber, like an echo. The ultrasonic vibrations echoing off the front wall pass through the fluids within the chamber a second time, further mixing the fluids.

Abstract: A fluid transport/containment apparatus includes a fluid-bearing module and an actuation module. The fluid-bearing module includes a substrate and fluid transport/containment elements distributed therein, with one or more of the fluid transport/containment elements having microfluidic dimensions. The actuation module is detachably secured to the fluid-bearing module such that the actuation elements are operatively interfaced with the fluid transport/containment elements.

Abstract: Methods comprising: providing a suspension comprising magnetizable particles; and delivering the suspension through a gap (3), wherein a magnetic field is applied in the gap, such that the suspension is sheared in the gap in the presence of the magnetic field to form a conditioned suspension; and devices for conditioning suspensions containing magnetizable particles, the device comprising a gap (3) through which the suspension containing magnetizable particles flows and in which a shear force is applied to the suspension containing magnetizable particles, wherein the device furthermore contains a magnet for generating a magnetic field in the gap (3).

Abstract: An optofluidic device forming a liquid grating, a liquid detector or a liquid emitter and method(s) of operation.

Abstract: The microfluidic device includes a rotatable platform, a plurality of connection ports disposed at a portion of the platform proximate to a shaft connection hole, the plurality of connection ports capable of being connected to an external connector for selectively injecting and discharging fluid and being closed by the connector, a trap chamber disposed at a portion of the platform further away from the shaft connection hole than the plurality of connection ports, the trap chamber including an inlet connected with at least one connection port of the plurality of connection ports, an outlet connected with another connection port of the plurality of connection ports and structures which enlarge a contact area with the fluid and a temporary storage including an inlet connected with the outlet of the trap chamber and an outlet connected with another connection port of the plurality of connection ports.

Abstract: The present invention fundamentally differs from conventional methods in which an external force is directly applied to a surface of an article to be modified, and relates to a method of hydrophobilization (increasing a contact angle of water) which comprises bringing a hydrophobilization substance (a substance for increasing a contact angle of water) released from a material of another location into contact with a surface of an article, especially an article surface being hydrophilic (having a small contact angle of water) in its initial state without applying an external force on the article surface, further a method of control being capable of noncontact switching of a contact angle of water, which comprises conducting hydrophilization of an article surface subjected to hydrophobilization by the above-mentioned method in a noncontact manner and repeating these hydrophobilization and hydrophilization, and a method of pattern formation using the mentioned methods.

Abstract: A fluid transport device transports fluid containing electrolytes within a flow channel. At least a portion of the inner walls of the flow channels are hydrophilic from the inlet to the outlet thereof except at least one valve portion. The device also includes: the valve portions, which are hydrophobic and function to block transport of at least one fluid; electrodes, which are provided at the at least one valve portion and function to reduce the surface tension of the fluid; and air vents, which are provided at the at least one valve portion and function to introduce air in order to block the fluid.

Abstract: The invention describes devices for controlling fluid flow, such as valves. The devices may include one or more electroactive polymer transducers with an electroactive polymer that deflects in response to an application of an electric field. The electroactive polymer may be in contact with a fluid where the deflection of the electroactive polymer may be used to change a characteristic of the fluid. Some of the characteristic of the fluid that may be changed include but are not limited to 1) a flow rate, 2) a flow direction, 3) a flow vorticity, 4) a flow momentum, 5) a flow mixing rate, 6) a flow turbulence rate, 7) a flow energy, 8) a flow thermodynamic property. The electroactive polymer may be a portion of a surface of a structure that is immersed in an external fluid flow, such as the surface of an airplane wing or the electroactive polymer may be a portion of a surface of a structure used in an internal flow, such as a bounding surface of a fluid conduit.

Abstract: An apparatus for generating a pressure wave in a medium is disclosed. The apparatus includes a plurality of pressure wave generators having respective moveable pistons, the pistons having respective control rods connected thereto. The apparatus also includes a plurality of transducers coupled to the medium and means for causing the pistons of respective ones of the plurality of the pressure wave generators to be accelerated toward respective ones of the plurality of transducers. The apparatus further includes means for causing restraining forces to be applied to respective control rods to cause respective pistons to impact respective transducers at respective desired times and with respective desired amounts of kinetic energy such that the respective desired amounts of kinetic energy are converted into a pressure wave in the medium.

Abstract: In one embodiment as described in this section, an apparatus for mixing of microfluidic streams on a chip is presented, which comprises a micro-channel and a plurality of magnetic valves on the chip. A guiding magnet produces a proximal magnetic field gradient to exert a force on a bead in a cavity when placed at in a vicinity of the chip. The bead-cavity combination form a magnetic valve. In one embodiment, the mouth of the cavity is tapered so to prevent the magnetic bead from completely blocking the corresponding micro-channel section to enhance the mixing of microfluidic streams at the narrowed fluid path. In one embodiment, magnetically actuated valves direct the flow in a microfluidic system in one of several flow paths wherein the mixing characteristics of the paths are different.

Abstract: The present invention provides a microfluidic system comprising at least one microchannel (18) having an inner wall (17). The microfluidic system comprises attached to the inner wall (17) of the at least one microchannel (18) a plurality of ciliary N actuator elements (10a-d) and at least one floating current wire (14a-d) present in the at least one microchannel (18) for applying a magnetic field to the plurality of ciliary actuator elements (10a-d) for changing their shape and/or orientation. The present invention also provides a method for the manufacturing of such microfluidic systems and to a method for controlling a fluid flow through a microchannel (18) of such a microfluidic system.

Abstract: A transport system for dry nanoparticles (18b). According to the invention, the nanoparticles (18b) are magnetized or electrically charged for transportation, a magnetic or electrical field is produced by a field generator (20a, 20) in the transport channel, and the nanoparticles (18b) migrate through the transport channel (12). The nanoparticles can be discharged through a discharge opening (13) which enables dosing to take place. In order to agglomerate the nanoparticles (18b) or to prevent attachment onto the inner wall (26), a coating (27) of the wall can be offset in oscillations by piezo electric actuators (28), the oscillations being transferred to the nanoparticles (18b). The dry nanoparticles can be handled in an advantageous manner due to the transport system, such that the dry nanoparticles need not be treated as a suspension.

Abstract: A method of controlling fluid through a layer of a soft compressible (e.g., gel) material including an array of fluid flow paths. The fluid flow paths are normally open, allowing fluid flow. An electric field is applied in regions where fluid flow is undesirable. The electric field compresses the material closing the flow path thereby preventing further fluid flow.

Abstract: The invention concerns a microfluidic liquid-movement device. The movement device according to the invention comprises a microchannel (10) provided with an opening (11B) onto the environment, the microchannel (10) being filled with a first liquid (F1) and a second liquid (F3), the two liquids being separated by a separating fluid (F2). Injection of the second liquid (F3) through the opening (11B) is obtained by movement of the first liquid (F1) by electrowetting.

Abstract: Disclosed herein is a micro-fluidic chip including a hollow area into which a charged droplet is introduced, and an electrode configured to be provided toward the hollow area. Movement direction of a droplet in the hollow area is controlled based on electric force acting between a charge given to the droplet and the electrode.

Abstract: Please replace the Abstract with the following amended Abstract: A magneto-rheological fluid valve includes a magnetic field generator having at least one electromagnetic coil and at least one magnetic pole having a pole length Lm. The magneto-rheological fluid valve further includes at least one flow channel adjacent to the magnetic field generator. The at least one flow channel has a gap width g, wherein the ratio Lm/g is greater than or equal to 15.

Abstract: A microchip includes a channel permitting a sheath liquid to flow therethrough; and a microtube for introducing a sample liquid into a laminar flow of the sheath liquid flowing through the channel; wherein liquid feeding is performed in the condition where a laminar flow of the sample liquid introduced through the microtube is surrounded by the laminar flow of the sheath liquid.

Abstract: A microfluidic structure with an electrically controlled pressure source is shown. The pressure source is an electrolyte connected with electrodes. Dissociation of the electrolyte generates the pressure, which is used to obtain a valve-like or pump-like behavior inside the microfluidic structure. A process for manufacturing the microfluidic structure and a method to circulate fluids in a microfluidic channel are also described.

Abstract: A system for monodispersed microdroplet generation and trapping including providing a flow channel in a microchip; producing microdroplets in the flow channel, the microdroplets movable in the flow channel; providing carrier fluid in the flow channel using a pump or pressure source; controlling movement of the microdroplets in the flow channel and trapping the microdroplets in a desired location in the flow channel. The system includes a microchip; a flow channel in the microchip; a droplet maker that generates microdroplets, the droplet maker connected to the flow channel; a carrier fluid in the flow channel, the carrier fluid introduced to the flow channel by a source of carrier fluid, the source of carrier fluid including a pump or pressure source; a valve connected to the carrier fluid that controls flow of the carrier fluid and enables trapping of the microdroplets.

Abstract: Methods and devices for moving a droplet on an elongated track on a textured surface using vibration. The elongated track on the textured surface includes a plurality of transverse arcuate projections such that a droplet on the surface is in the Fakir state and when the surface is vibrated the droplet is urged along the track as a result of an imbalance in the adhesion of a front portion of the droplet and a back portion of the droplet to the textured surface.

Abstract: The invention describes devices for controlling fluid flow, such as valves. The devices may include one or more electroactive polymer transducers with an electroactive polymer that deflects in response to an application of an electric field. The electroactive polymer may be in contact with a fluid where the deflection of the electroactive polymer may be used to change a characteristic of the fluid. Some of the characteristic of the fluid that may be changed include but are not limited to 1) a flow rate, 2) a flow direction, 3) a flow vorticity, 4) a flow momentum, 5) a flow mixing rate, 6) a flow turbulence rate, 7) a flow energy, 8) a flow thermodynamic property. The electroactive polymer may be a portion of a surface of a structure that is immersed in an external fluid flow, such as the surface of an airplane wing or the electroactive polymer may be a portion of a surface of a structure used in an internal flow, such as a bounding surface of a fluid conduit.

Abstract: The invention relates to a microfluidic device comprising a first plate forming the substrate and including at least one perforation and, on either side of said first plate, at several locations, a material for defining passage portions consisting, in at least one of said locations, of an activatable material varying in volume on activation, said material being disposed at said locations in an arrangement that, during a first phase and upon activation of at least one location consisting of said activatable material, transforms it from a first configuration to a second configuration, modifying a three-dimensional network corresponding, in the second configuration and depending on the selected location(s) that are activated in said first phase, to different liquid paths including passage portions in offset planes parallel to the plane of the first plate, at least on either side of said first plate, and between which at least one of said perforations is located.

Abstract: A micropump device including a first wafer and a second wafer attached to the first wafer. The first and second wafers are configured to define a chamber therebetween having a predetermined volume. A third wafer is attached to the second wafer to define an inlet section and an outlet section in fluid communication with the chamber. At least one of the second and third wafers are formed to define a moveable diaphragm configured to change the predetermined volume of the chamber for pumping a fluid between the inlet section and the outlet section.

Abstract: A micro-fluidic system comprises at least one micro-channel having a wall (14), a plurality of ciliary actuator elements (71) attached to said wall (14), said ciliary actuator elements (71) having an original shape when not subjected to a liquid, and means for applying stimuli to said plurality of ciliary actuator elements (71) so as to cause a change in their shape from an initial shape to an end shape. The ciliary actuator elements (71) are adapted to respond to the presence of a particular liquid by changing their original shape into the initial shape. The response to the presence of the particular liquid may be a curving of the original shape of the ciliary actuator element. Application of stimuli to the plurality of ciliary actuator elements provides a way to locally manipulate the flow of complex fluids in a micro-fluidic system.

Abstract: A device for fluid processor comprises a plate-shaped base material, a micro conduit network formed in the base material and formed of a first micro conduit and second micro conduits intersecting with the first micro conduit, a valve provided in each of conduit portions and a valve control mechanism. The valves in the conduit portions are closed, whereby a fluid running route is set, thereby forming a fluid processor that an intended processing is conducted by circulating a fluid through the running route. A fluid suspending cavity is preferably formed at each of the intersections of the micro conduits. A fluid running route setting apparatus is equipped with a conduit portion opening and closing mechanism having a function that individual valve control mechanisms in the device are driven, and the conduit portion opening and closing mechanism is driven by indication of fluid running route setting to a computer.

Abstract: An electroosmotic flow pump is filled with a driving liquid exhibiting electroosmotic phenomenon, and a transport liquid capable of noncontact movement through a valve as the driving liquid moves. Since only the driving liquid can pass through an electroosmotic material, even a transport liquid not exhibiting electroosmotic phenomenon can be transported by utilizing the electroosmotic flow pump. Consequently, the electroosmotic flow pump can transport any transport liquid stably so long as the driving liquid exhibits electroosmotic phenomenon.

Abstract: A method and apparatus for controlling multi-fluid flow in a micro channel is disclosed. The apparatus has a first inlet for a first fluid; a second inlet for a second fluid; a first outlet; and a second outlet. The micro channel is operatively and fluidically connected to the first inlet, the second inlet, the first outlet and the second outlet. The micro channel is for receiving the first fluid and the second fluid under pressure-driven flow; there being an interface between the first fluid and the second fluid when in the micro channel. The apparatus also includes a pair of electrodes for having a first electric field applied thereto for a controlling the fluid flow velocity of the first fluid along the micro channel.

Abstract: A liquid sending method includes the step of introducing either one fluid of a gas or an insulating liquid into a channel disposed on a substrate, thereby dividing a liquid flowing in the channel and sending the liquid.

Abstract: The invention relates to a method for treating drops in a microfluid circuit, comprising at least one microchannel (12) through which the drops flow, characterized in that a laser (26) is brought to bear on the interface of said drops in the transport liquid (F3), or on the interface of drops in contact, in order to carry out a sorting of the drops, to form nanodrops from a larger drop or to fuse drops (60, 64) in contact and initiate reactions between the fluids contained in said drops.

Abstract: Disclosed are compositions and methods for producing movement of liquid across surfaces.

Abstract: Microfluidic system (1, 2, 10, 11, 16) comprising a first portion (3, 4, 24, 25) and a second portion (5-7), said first portion (3, 4) comprising a material which is able to change its volume when activated by an exciting factor, characterized by the fact that said first portion (3, 4) and said second portion (5-7) define a zone (3-7) which, when said first portion (3,4) is not yet activated by said exciting factor, shows a first topography devoid of any fluidic pathway and which, after activation by said exciting factor, shows a second topography (9, 14) which is adapted to contain at least one fluidic pathway, said microfluidic system furthermore comprising a tight cover surface (20) situated above said first portion (3, 4) and said second portion (5-7).

Abstract: A method for inducing a controllable jet in a transparent liquid is disclosed. The method comprises providing a gas-liquid interface, providing a laser source and generating a beam comprising a sequence of laser pulses, and focusing the beam to a target location within the liquid at a predetermined distance from the gas-liquid interface and creating a plurality of cavitation bubbles, yielding a jet directed away from the gas-liquid interface. Other methods and apparatus are also described and claimed.

Abstract: Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves.

Abstract: A microreactor containing a plurality of introduction channels 21 and 22 for introducing a plurality of liquids, a merging section 23 for merging the plurality of introduction channels 21 and 22, and a reaction channel 41 located on a downstream side of the merging section 23, characterized in that a flow control section 80 is located on a downstream side of the merging section 23 and an upstream side of the reaction channel 41, and the flow control section 80 contains in a channel 81 thereof a movable particle 82. According to the constitution, such a microreactor can be provided that the flow state in the reaction channel 41 is controlled to realize a flow state with good reproducibility.

Abstract: The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.

Abstract: A system for controlling fluid flow in a microfluidic circuit includes at least one microfluidic channel having a first fluid, a switch element coupled to the microfluidic channel, the switch element comprising at least one inlet, at least one outlet and a second fluid, the second fluid being immiscible with respect to the first fluid. The system also includes an actuator configured to alter the position of the second fluid, such that when in a first position, the second fluid allows the first fluid to flow from the at least one inlet to the at least one outlet, and such that when in a second position, the second fluid prevents the first fluid from flowing from the at least one inlet to the at least one outlet.

Abstract: A method of microfluidic control via localized heating includes providing a microchannel structure with a base region that is partially filled with a volume of liquid being separated from a gas by a liquid-gas interface region. The base region includes one or more physical structures. The method further includes supplying energy input to a portion of the one or more physical structures within the volume of liquid in a vicinity of the liquid-gas interface region to cause localized heating of the portion of the one or more physical structures. The method also includes transferring heat from the portion of the one or more physical structures to surrounding liquid in the vicinity of the liquid-gas interface region and generating an interphase mass transport at the liquid-gas interface region or across a gas bubble while the volume of liquid and the gas remain to be substantially at ambient temperature.

Abstract: A fluid delivery device is provided which comprises a microchannel device for cutting out a certain amount of a sample from a micorochannel by controlling a valve opening. The fluid delivery device has a valve for controlling a flow of a fluid, comprising a flow channel for the fluid, and a valve in the flow channel, wherein the valve operates in accordance with a pressure difference between the upstream side and downstream side of the valve caused by the flow of the fluid through the flow channel, allowing the fluid to flow when the pressure difference is lower than a prescribed value P0, and intercepting the fluid not to flow when the pressure difference is P0 or more.

Abstract: A microfluidic circuit comprising microchannels (24, 26) containing different fluids (F1, F2), with a laser beam being focused at (32) on an interface (30) between the fluids so as to form a pump, a valve, or a mixer, for example.

Abstract: A microdevice is constructed from a substrate having a microchannel formed therein and a cover plate arranged over the substrate. The cover plate in combination with the microchannel at least partially defines a conduit within the microdevice. The conduit has a surface that extends from an upstream region toward a downstream region and terminates at an opening. The microdevice also includes an annular lining that conforms to the conduit surface at the downstream region and extends from the opening toward the upstream region in the conduit. An emitter may be produced in situ by depositing an emitter material on the annular lining. In addition, material may be removed from the cover plate and/or substrate about the opening. As a result, an exterior microdevice surface is formed and a downstream portion of the emitter is exposed that protrudes from the exterior surface.

Abstract: A microfluidic system, particularly a microfluidic chip, with at least one operational channel, in which a fluid and/or the constituents contained therein are moveable in the direction of the operational channel by a driving force, particularly by using pressure, acoustic energy, or an electrical and/or a magnetic field. At least one measurement sensor used to measure a measurable value assigned to the fluid and derivable in the region of the fluid and at least one regulator is provided to regulate the driving force and/or a parameter that may be influenced by it, wherein the regulator is coupled with a measurement sensor and a device used to alter the driving force and/or the parameter that may be influenced by it. The microfluidic system further relates to a procedure to transport and guide a fluid and/or the constituents contained therein within a microfluidic system of the type described above.

Abstract: A magnetostatic actuator uses a ferrofluid slug confined in a cylindrical tube which is wrapped in a conducting coil. By applying a current to the coil, a magnetic field is generated inside the coil. The ferrofluid slug may be attracted to the interior of the coil by the interaction of its magnetic moment with the field generated inside the coil. Movement of the ferrofluid slug in response to the magnetic field may be used to actuate various devices, such as a droplet dispenser.

Abstract: A method is provided for fabricating a constriction region in a channel of a microfluidic device. The method includes the steps of introducing a pre-polymer mixture including a monomer, cross-linking agent and photoinitiator into the channel. The pre-polymer mixture is polymerized at a localized area of the channel so as to shrink and solidify the liquid mixture. The solidified and shrunken liquid mixture provides the constriction region in the channel.

Abstract: A micro-filter for filtering blood cells has a plurality of filtering channel structures, each having a first through hole and a first concave portion connecting to each other, and a plurality of through channel structures respectively connect to the filtering channel structures. Each defines a second through hole opposite the first concave portion, whereby the filtering channel structures are respectively attached to the through channel structures to provide more than two filtering effects.

Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

Abstract: Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces which is recessed back from an adjacent portion of the edge. Hydrophilic surfaces and/or hydrophobic surfaces guide substances out of the outlet. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

Abstract: An apparatus for simultaneously aligning and interconnecting microfluidic ports is presented. Such interconnections are required to utilize microfluidic devices fabricated in Micro-Electromechanical-Systems (MEMS) technologies, that have multiple fluidic access ports (e.g. 100 micron diameter) within a small footprint, (e.g. 3 mm×6 mm). Fanout of the small ports of a microfluidic device to a larger diameter (e.g. 500 microns) facilitates packaging and interconnection of the microfluidic device to printed wiring boards, electronics packages, fluidic manifolds etc.

Abstract: A flow pipe and one or more permanent magnets placed in or on the flow pipe, each permanent magnet presenting at its axial ends an infinite divergence of the magnetic field it generates. Fluid is treated by flowing through a flow pipe equipped with at least one such permanent magnet. The permanent magnet can be made of a plastic coextrudate with a ferromagnetic material such as iron powder, iron dust or iron chips. The permanent magnets can be arranged in groups with flow turbulence initiators positioned within the flow pipe between the magnet groups.

Abstract: Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

Abstract: A method and flow system for controlling the flow of a liquid in a flow system, the liquid flow comprising particles and being led into a channel thereof. The method comprises the steps of enveloping the liquid flow by a flow of carrier liquid, hydrodynamically focussing the particles in the liquid flow providing a measurement signal of the liquid flow from an observation area in the channel, and dividing the liquid flow at a branching point into two or more outlets in response to the measurement signal. The division of the liquid comprises introducing a control liquid from at least one control channel at a merging point or merging area in the channel. The amount of control liquid is controlled by at least one electro-kinetic pump, the pump effect of which is controlled in response to the measurement signal.