Abstract: A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.
Type:
Grant
Filed:
November 4, 1999
Date of Patent:
September 9, 2003
Assignee:
TheraSense, Inc.
Inventors:
Charles T. Liamos, Joseph A. Vivolo, Fredric C. Colman
Abstract: A biosensor, a measuring instrument for biosensor, and a method of quantifying a substrate contained in specimen liquid to reduce a measurement error by the biosensor; a biosensor, comprising at least a pair of electrodes formed on an insulation substrate; a measuring instrument, comprising a supporting part for detachably supporting the biosensor, a plurality of connection terminals electrically connected to the electrodes, and a drive power supply for applying a voltage to the electrodes through the connection terminals; wherein the biosensor is inserted into the measuring instrument, either one of the electrodes of the biosensor is connected to first and second connection terminals fined to the measuring instrument only when the biosensor is inserted into the support part of the measuring instrument in a specified direction and has an electrode structure to allow the first connection terminal to conduct with the second connection terminal when a voltage is applied by the drive power supply.
Abstract: The present invention is to provide a concentration measuring apparatus, a test strip for the concentration measuring apparatus, a biosensor system and a method for forming terminals of the test strip, whereby a component to be measured can be measured by the test strip fit to the target component to be measured.
Abstract: The present invention is to provide a concentration measuring apparatus, a test strip for the concentration measuring apparatus, a biosensor system and a method for forming terminals of the test strip, whereby a component to be measured can be measured by the test strip fit to the target component to be measured. A type judgement electrode is provided separately from a positive electrode and a negative electrode in a measuring apparatus so as to judge the type of a set test strip with the measuring apparatus. Thus only when a test strip matching the measuring apparatus is set, the type judgement electrode is electrically connected to a terminal of the set test strip, enabling the measuring apparatus to measure a component to be measured in a liquid test sample.
Abstract: The present invention provides a so improved biosensor that a whole blood is allowed to be an object to be measured, and that plasma of a blood, with hemocytes thereof having been filtered out, is allowed to quickly reach an electrode system.
Type:
Application
Filed:
January 24, 2003
Publication date:
July 17, 2003
Applicant:
Matsushita Electric Industrial Co., Ltd.
Abstract: Described are micro-arrays of electrodes disposed proximal to a flexible substrate, electronic components and sensors comprising such arrays, and methods of use for such arrays.
Type:
Application
Filed:
October 4, 2002
Publication date:
June 26, 2003
Inventors:
Nigel A. Surridge, Christopher D. Wilsey
Abstract: A sensor (10,110) is provided for determination of various concentrations of one or more components within a fluid sample. The sensor (10,110) includes an injection molded body (12,112), at least two electrodes (30,31,32,130,131,132), an enzyme (57,157), and, if desired, an electron transfer mediator. The body includes a reaction zone (24,124) for receiving a fluid sample. The electrodes (30,31,32,130,131,132) are at least partially embedded with in the plastic body (12,112) and extend into the reaction zone (24,124). Also contained within the reaction zone is an enzyme (57,157) capable of catalyzing a reaction involving a compound within the fluid sample.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
June 10, 2003
Assignee:
Virotek, L.L.C.
Inventors:
Craig Rappin, Kiamars Hajizadeh, Kelly Mills
Abstract: A sensor is provided for the determination of various concentrations of one or more components within a fluid sample. The sensor includes an injection molded body, at least two electrodes, an enzyme, and if desired, an electron transfer mediator. The body includes a reaction zone for receiving a fluid sample. The electrodes are at least partially embedded within the plastic body and extend into the reaction zone. Also contained within the reaction zone is an enzyme capable of catalyzing a reaction involving a compound within the fluid sample. Additionally, the sensor incorporates fill detection which activates a meter, attached to the sensor, for measuring the electrochemical changes occurring in the reaction zone.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
June 3, 2003
Assignee:
Virotek, L.L.C.
Inventors:
Craig Rappin, Kiamars Hajizadeh, Kelly Mills
Abstract: According to an aspect of the invention, an electrochemical cell for analysis of a sample is provided, comprising a dual electrode having a dielectric strip with electrical conductors on opposite sides. According to a preferred embodiment, the electrochemical cell comprises a base, and a first reagent the proximate the dual electrode. According to a further preferred embodiment, a second reagent is provided proximate the dual electrode. A cover may also be provided comprising a sample aperture. According to a particularly preferred embodiment, the first and second reagents are superposed, and the dual electrode is between the first and second reagents. The dual electrode separates the two and preserves chemical stability until a sample is applied.
Type:
Grant
Filed:
December 30, 1999
Date of Patent:
May 13, 2003
Assignee:
Roche Diagnostics Corporation
Inventors:
Raghbir Singh Bhullar, Douglas P. Walling, Brian Hill
Abstract: A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a first surface coupled to the substrate and a second surface. The first surface is carved so that it includes a flow channel therein. The flow channel extends over at least a portion of the reagent. In addition, the cover includes secondary channels extending on either side of the channel.
Type:
Grant
Filed:
November 1, 2000
Date of Patent:
April 1, 2003
Assignee:
Roche Diagnostics Corporation
Inventors:
Raghbir S. Bhullar, Douglas P. Walling, Brian S. Hill
Abstract: A method of making a set of metallic deposits includes injection molding a substrate, where a pattern of channels is in a surface of the substrate, applying a metallic layer on the surface, to form metallic deposits in the pattern, and removing a portion of the metallic layer, to expose a portion of the surface. The set of metallic deposits can form an electrode set for an electrochemical sensor strip.