Abstract: A biosensor measurement device for providing accurate measurement results within a short period of time by using only a very small amount of sample. The biosensor measurement device includes a power source, which is connected to a voltage regulator, a measurement instrument, and a controller for supplying power. When the biosensor chip is connected to the biosensor measurement device and a voltage is applied, the measurement instrument begins the measurement of a current value for the biosensor. When the measured current value or a measured charge value is greater than a reference value, the measurement is terminated in accordance with an instruction issued by the controller, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.

Abstract: Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information.

Abstract: An electrochemical test sensor includes a base, a generally hard electrically-conductive layer, an electrochemically-active layer, and a lid. The electrically-conductive layer is located between the base and the electrochemically-active layer. The electrically-conductive layer and the electrochemically-active layer are made of a different material. The electrically-conductive layer and the electrochemically-active layer form an electrode pattern. The electrochemical test sensor includes a reagent adapted to assist in determining information related to an analyte of a fluid sample.

Abstract: A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.

Abstract: The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted. In one embodiment, a first test strip comprises: a first measurement electrode connectable to a test meter; a first trace loop with a first associated resistance, where the first trace loop is connectable to the test meter; and a second trace loop with a second associated resistance, where the second trace loop is connectable to the test meter. The test meter is adapted to: receive the first test strip; connect to the first measurement electrode, the first trace loop, and the second trace loop; and obtain a first resistance ratio by comparing the first and second associated resistances.

Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.

Abstract: A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.

Abstract: An electrochemical test sensor configured to determine an analyte concentration of a fluid sample comprises a base including a first end, a second opposing end, a first side and a second side bridging the first and second opposing ends. The test sensor further comprises a plurality of electrodes formed on the base at or near the first end. The plurality of electrodes includes a working electrode and a counter electrode. The sensor further comprises a first test-sensor contact formed on the base at or near the second opposing end and coupled to the working electrode by a first conductive lead. The sensor further comprises a second test-sensor contact formed on the base at or near the second opposing end and coupled to the counter electrode by a second conductive lead. The positions of the first and second test-sensor contacts correspond with calibration information assigned to the test sensor.

Abstract: A medical device includes a connector which contacts a sensor to electrically connect the sensor with a measurement circuit in a medical device, a contact terminal which constitutes the connector, and a slide pin which ejects the sensor out of the medical device. The slide pin performs the operation of pushing up the contact terminal contacting the sensor as well as the operation of pushing the sensor out of the medical device. Since the contact terminal is completely lifted up by the inclined surface of the upper end part of the slide pin before the sensor is discarded, there occurs no reaction due to rebound of the contact terminal which might occur at the moment when the contact terminal of the connector is separated from the sensor, and thereby the sensor can be discarded so as to fall freely.

Abstract: A hand-held test meter for use with an analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a buttons electrical circuit block, at least one user operable button in operable communication with the buttons electrical circuit block, a microcontroller block, and a first-time-on (FTO) electrical circuit block. The FTO electrical circuit block is disposed within the housing and includes an activation node and a signal reception contact. In addition, the FTO electrical circuit block is configured to place the hand-held test meter into a deep power conservation mode upon either the direct application of an electrical signal to the activation node by an external device (e.g., a manufacturing tester) or a deactivation signal received at the signal reception contact.

Abstract: Enzyme-based electrochemical sensors comprising transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators and include substituted or unsubstituted pyridyl-imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.

Abstract: An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

Abstract: Ion concentration measurement requires a calibration before the start of the measurement, and thus the start of the measurement is delayed for the calibration period. Hence, an ion selective electrode cartridge including an ion selective electrode for measuring the concentration of particular ions dissolved in a test solution is provided with a storage means storing therein an electrode slope value specific to the ion selective electrode.

Abstract: A wet flow-type ion selective electrode device requires not only a large amount of test solution but also cumbersome management works such as flow path cleaning and device conditioning. Provided is an ion selective electrode cartridge which includes at least one ion selective electrode forming an electrical path with a reference electrode when a test solution is infused, and in which the ion selective electrode and the reference electrode is arranged to surround a container.

Abstract: A device combining a fuel-cell-type breathalyser with an electrochemical saliva drug test. The saliva drug tester comprises a disposable test strip-electrode module assembly and an analyser module. The saliva is squeezed out of an absorbent swab when the test strip is inserted into the electrode module. The electrode module can also carry information that is read and evaluated by the analyser, e.g. for verification of the electrode module.

Abstract: A disposable electrochemical sensor strip is provided. The sensor strip includes an isolating sheet having at least a through hole, at least a conductive raw material mounted in the through hole, a metal film covered on the conductive raw material to form an electrode which comprises an electrode working surface for processing an electrode action, and an electrode connecting surface, at least a printed conductive film mounted on the isolating sheet and having a connecting terminal for being electrically connected to the electrode connecting surface, and a signal output terminal for outputting a measured signal produced by the electrode action.

Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

Abstract: A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.

Abstract: Disclosed is an electrode strip for an electrochemical biosensor, which is fabricated by forming a nickel-including metal layer on a non-conductive substrate including a polymer material, forming a carbon layer thereon, and carrying out patterning.

Abstract: A method of producing a biomaterial measuring device is disclosed. The method includes forming a plurality of reactions elements, to which an assay reagent is applied, on a first substrate, cutting the resulting first substrate in a unit of individual reaction element, and attaching a first substrate piece, which is formed by cutting the resulting first substrate in the unit of individual reaction element, to a predetermined portion of a second substrate. In the biomaterial measuring device, since a material cost in minimized and it is easy to automate production, it is possible to reduce a production, it is possible to reduce a production cost.

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.

Abstract: The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with non-human IgM or fragments thereof by dissolving into said sample a dry reagent to yield a non-human IgM concentration of at least about 20 ?g/mL or equivalent fragment concentration; and (b) performing an electrochemical immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG or fragments thereof in addition to the IgM of fragments thereof.

Abstract: A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1.

Abstract: An analyte test strip for use with a test meter includes a first insulating layer, a first electrically conductive layer disposed on the first insulating layer, a second insulating layer disposed above the first insulating layer, and a patterned spacer layer, positioned between the first insulating layer and the first electrically conductive layer, that defines a sample-receiving chamber. Moreover, the electrically conductive layer includes an electrode portion that is divided into a first electrode sub-portion and a second electrode sub-portion. The electrically conductive layer also includes (i) a first electrical contact pad in electrical communication with the first electrode sub-portion and configured to communicate an electrical response of the first electrical sub-portion to the test meter, and (ii) a second electrical contact pad in electrical communication with the second electrode sub-portion and configured to communicate an electrical response of the second electrical sub-portion to the test meter.

Abstract: A sample cartridge for measuring the electrical characteristics of a liquid sample, which is made by forming an insulating material into a tubular body and is capable of holding the liquid sample in a region that is constituted by the surfaces of electrodes that are respectively inserted from openings of both ends into an inner cavity and the surface of the inner cavity, and in which a narrowing portion located between two facing electrodes and having a narrowed inner cavity is provided in the region.

Abstract: Not only a downsized cartridge but also an aperture constituted simply and at low cost using a downsized configuration of the cartridge is provided. A measurement channel includes a front-surface-side channel unit provided on a front surface of a cartridge main body; a rear-surface-side channel unit provided on a rear surface of the cartridge main body; and a connection channel unit connecting the front-surface-side channel unit to the rear-surface-side channel unit. An aperture is formed in the connection channel unit, a fluid contact unit of one electrode is arranged in the front-surface-side channel unit, and a fluid contact unit of the other electrode is arranged in the rear-surface-side channel unit.

Abstract: Disclosed herein is an electrochemical sensor for detecting an analyte. The sensor comprises an electrode, a redox active species that is electrochemically accessible to the electrode, and a binding moiety capable of associating with the analyte, wherein association of the binding moiety with the analyte affects the electrochemistry of the redox active species. Also disclosed herein is a method for detecting the presence of an analyte in a sample.

Abstract: Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a fill time of the sample into the device is calculated. A concentration of the analyte in view of fill time can then be determined. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.

Abstract: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

Abstract: A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.

Abstract: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

Abstract: This sensor chip (11) comprises a substrate (15) in the form of a flat board, a sample inlet (20) that is provided in the thickness direction of the substrate (15) and into which flows the blood (3) used for measurement, a supply path (21) that communicates with this sample inlet (20), and detection electrodes (17, 18, 19) provided to this supply path (21), wherein the substrate (15) is provided with a surplus blood reservoir (25) that draws in surplus blood (3a) and holds this drawn surplus blood (3a).

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Abstract: This invention is a method for determining a concentration of an analyte. The steps include applying a potential excitation to a fluid sample containing an analyte, and measuring a current associated with the potential excitation at a plurality of time-points. The method also includes calculating an analyte concentration based on the measured current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments.

Abstract: The present invention provides a testing strip for detecting a fluidic sample for testing a fluidic sample. The testing strip for detecting a fluidic sample comprises a substrate, a plurality of electrodes, a supporting layer and a cover that are serially stacked. The testing strip for detecting a fluidic sample includes a longitudinal long axis and a transverse short axis. The testing strip for detecting a fluidic sample includes a first end and a second end opposing to the first end along the longitudinal long axis. The testing strip for detecting a fluidic sample includes a reacting region located at the terminal of the first end, and the reacting region is defined and enclosed by the cover, the supporting layer and the substrate. The reacting region has a C-liked structure from a cross-sectional view taken along a direction perpendicular to the longest flowing path of the fluidic sample.

Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: Analyte meter protectors, meters that include the same, and methods. In one example, a ketone monitoring system is provided wherein a port protector is used in combination with a meter.

Abstract: Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.

Abstract: A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ?S, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, whole blood) includes an electrically insulating base layer, a patterned conductor layer disposed over the electrically-insulating layer, and a patterned insulation layer, with an electrode exposure window therethrough, disposed over the patterned conductor layer. The patterned conductive layer of the electrochemical-based analytical test strip includes at least one working electrode and a counter/reference electrode. In addition, at least a portion of the electrode exposure window is configured to expose a working electrode exposed portion and a counter/reference electrode exposed portion, with the working electrode exposed portion being rectangular in shape and the counter/reference electrode exposed portion being one of a crossroads shape and an at least six-sided portion of a crossroads shape.

Abstract: A sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector.

Abstract: A blood sensor to be used in a blood test apparatus, more specifically speaking, a blood sensor which can be easily attached to a blood test apparatus and detached therefrom. Namely, a blood sensor to be detachably attached to a blood test apparatus having a plural number of connectors, which comprises: a supply channel to which blood is supplied; a detection section provided in the supply channel; an electrode system formed in an area including the detection section; a plural number of connection terminals electrically connected to each electrode of the electrode system respectively; and a standard electrode serving as a standard for differentiating these connection terminals. The connectors are connected respectively to the connection terminals and the standard electrode of the blood sensor having been attached to a definite position of the blood test apparatus.