Enzyme Included In Apparatus Patents (Class 204/403.14)
  • Patent number: 11457840
    Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: October 4, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Udo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
  • Patent number: 11428664
    Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: August 30, 2022
    Assignee: Indian Institute of Science
    Inventors: Vinay Kumar, Navakanta Bhat
  • Patent number: 11254971
    Abstract: The present invention relates to a method and kit for amplifying and detecting a quantity of nucleic acid. The invention is particularly relevant to isothermal amplification techniques carried out on a flow based assay device. The amplified nucleic acid may be detected on the device using an optical read-out.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: February 22, 2022
    Inventor: Gustavo Andrés Cerda-Moya
  • Patent number: 11225645
    Abstract: The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase, According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 18, 2022
    Assignees: Ikeda Food Research Co., Ltd., PHC Corporation
    Inventors: Hironori Omura, Hirokazu Sanada, Takako Yada, Tetsunari Morita, Mika Kuyama, Tokuji Ikeda, Kenji Kano, Seiya Tsujimura
  • Patent number: 11180790
    Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: November 23, 2021
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
  • Patent number: 11143595
    Abstract: A plasma spectroscopy analysis method includes a preliminary addition process in which a bonding agent that is an agent other than DMSA is added to the specimen collected from a living body to which meso-2,3-dimercaptosuccinic acid (DMSA) is administered, a concentration process in which the analyte heavy metal ions in the specimen at a vicinity of one of a pair of electrodes by applying a voltage to the pair of electrodes, and a detection process in which plasma is generated by applying a voltage to the pair of electrodes, and luminescence of the analyte metal ions caused by the plasma is detected.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 12, 2021
    Assignee: ARKRAY, Inc.
    Inventors: Tsuyoshi Takasu, Kojiro Honma
  • Patent number: 11009479
    Abstract: A sensor for the detection of HbA1c in a sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and an anti-HbA1c antibody functionalized or chemically functionalized to a surface of an exposed portion of the working electrode.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: May 18, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Chung Chiun Liu, Alireza Molazemhosseini
  • Patent number: 10866205
    Abstract: Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b).
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: December 15, 2020
    Assignee: PHC Holdings Corporation
    Inventors: Masaki Fujiwara, Shin Ikeda, Takahiro Nakaminami
  • Patent number: 10867719
    Abstract: Disclosed are compositions of electroactive polymers (EAPs) having improved performance stability. In the EAP compositions, a cross-linked polymer is deposited onto the surface of the EAP by vapor-deposition methods. Upon contact with an aqueous solution (e.g., an aqueous electrolyte solution), the vapor-deposited polymeric network becomes a hydrogel that encapsulates the EAPs. By modulating precursors and vapor deposition conditions, the mesh size of the resultant hydrogel coatings can be controlled to accommodate the key species that interact with the EAPs.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: December 15, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Andong Liu, Karen K. Gleason, T. Alan Hatton, Xianwen Mao
  • Patent number: 10852267
    Abstract: A biosensor electrode comprises comprising a porous structure comprising a plurality of metal ligaments and a plurality of pores; and at least one carbon nanotube structure embedded in the porous structure and comprising a plurality of carbon nanotubes joined end to end by van der Waals attractive force, wherein the plurality of carbon nanotubes are arranged along a same direction.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: December 1, 2020
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Hong-Ying Fu, Wen-Zhen Li
  • Patent number: 10845335
    Abstract: An electrochemical tongue can be used for detection of metal ions. The reference electrode of the electrochemical tongue can be coated with a polymer. More than one reference electrode can be used, and the electrochemical tongue can be inserted into a cone penetrometer for portable, in situ analysis.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: November 24, 2020
    Assignee: University of Massachusetts
    Inventors: Pradeep Kurup, Ramaswamy Nagarajan, Timothy Ponrathnam, Weeradech Kiratitanavit
  • Patent number: 10791928
    Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: October 6, 2020
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Robert J. Boock, Mark C. Brister, Monica A. Rixman, Kum Ming Woo, Lisa Nguyen, Seth R. Brunner, Arthur Chee, Melissa A. Nicholas, Matthew D. Wightlin, Jack Pryor, Dubravka Markovic
  • Patent number: 10761044
    Abstract: A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: September 1, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Yoshifumi Takahara, Takahiro Nakaminami, Shin Ikeda
  • Patent number: 10655160
    Abstract: A formaldehyde electrochemical sensor employing a formaldehyde sensitive assembly of formaldehyde dehydrogenase attached to graphene in fluid communication with a source of NAD+, and a method of measuring formaldehyde utilizing the sensor.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: May 19, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Tianhong Cui, Shota Sando
  • Patent number: 10571424
    Abstract: The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: February 25, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Motonori Uchiyama, Takuo Kouno
  • Patent number: 10537889
    Abstract: Disclosed are methods and systems concerning flow cells for sequencing a nucleic acid sample that may be characterized by the following components: (a) a substrate having an inner surface facing a library sequencing region, and an outer surface; (b) a plurality of a plurality of forward and reverse amplification primers immobilized over the inner surface and providing a nucleic acid library capture surface of the library sequencing region; (c) a plurality of electrodes disposed along the inner surface directly under at least some of the forward and reverse amplification primers, and configured to provide, when charged, an electric field through the library capture surface and into the library sequencing region; (d) electrical leads connected to the plurality of electrodes to permit the electrodes to be independently addressable; and (e) fluidic couplings configured to deliver a plurality of nucleic acid libraries to the flow cell during different time periods.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: January 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Chenlu Hou, Byoungsok Jung, Yir-Shyuan Wu, Tarun Khurana
  • Patent number: 10501770
    Abstract: Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or more biocompatible binders, one or more biocompatible mediators, an enzyme, an enzyme stabilizer, and a conductive material. The system includes a dispenser including a chamber to hold the enzymatic-ink and an applicator to apply the enzymatic ink dispensed from the chamber onto a target substrate.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Joseph Wang, Amay Jairaj Bandodkar
  • Patent number: 10478829
    Abstract: Collector compositions C for mineral flotation, which include at least one of a hydroxamic acid A, and/or a salt S of a hydroxamic acid A solubilized in a water-soluble organic solvent L, and processes for using same for recovering sulfide and/or oxide minerals in mineral flotation processes are provided herewith.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: November 19, 2019
    Assignee: Cytec Industries Inc.
    Inventors: Tarun Bhambhani, Jason Freeman, Devarayasamudram R. Nagaraj
  • Patent number: 10413914
    Abstract: The present invention is directed to methods that can be used in the enrichment of metal sulfide ores in desired minerals in cases where the ores have sulfide-containing gangues. The method involves adding an oxidant to slurries prepared from the ores during, or immediately prior to froth flotation.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: September 17, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Gerhard Arnold, Terry Brown, Ingo Hamann, Alan Hitchiner
  • Patent number: 10327677
    Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: June 25, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Udo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
  • Patent number: 10324058
    Abstract: Embodiments of the invention provide an in-situ polymerization technique for creating a glucose sensor chemistry stack. An analyte sensor comprises a crosslinked polymer matrix in contact with an electrode. The crosslinked polymer matrix is formed by exposing ultraviolet (UV) light to a polymer matrix mixture comprising a plurality of hydroxyethyl methacrylate (HEMA) monomers, one or more di-acrylate crosslinkers, one or more UV photoinitiators, and an oxidoreductase. The oxidoreductase is covalently linked to the crosslinked polymer matrix. In typical embodiments, the oxidoreductase is a glucose oxidase-acrylate bioconjugate. In one or more embodiments, the analyte sensor apparatus further comprises a glucose limiting membrane positioned over the crosslinked polymer matrix.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: June 18, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Ashwin K. Rao, Daniel E. Pesantez
  • Patent number: 10246786
    Abstract: An inexpensive, easily renewable bioelectronic device useful for bioreactors, biosensors, and biofuel cells includes an electrically conductive carbon electrode and a bioelectronic interface bonded to a surface of the electrically conductive carbon electrode, wherein the bioelectronic interface includes catalytically active material that is electrostatically bound directly or indirectly to the electrically conductive carbon electrode to facilitate easy removal upon a change in pH, thereby allowing easy regeneration of the bioelectronic interface.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: April 2, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Robert Mark Worden, Brian L. Hassler, Lawrence T. Drzal, IIsoon Lee
  • Patent number: 10228341
    Abstract: A biosensor includes a plurality of electrodes including a working electrode, and a detection layer which is immobilized on the working electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the working electrode. The working electrode is in an open system.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 12, 2019
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Katsuki, Megumi Saeda, Junko Shimazaki
  • Patent number: 10179927
    Abstract: The present invention provides a method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises (a) contacting the sample with an electrochemically active reporter, wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of resorufin and compounds of formula (I) as defined herein, under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism; (b) electrochemically determining the released redox active reporter moiety; and (c) determining the presence of the microorganism and, op
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: January 15, 2019
    Assignees: Nanyang Technological University, National University of Singapore
    Inventors: Jamie Hinks, Jing Ying Evelina Han, Say Chye Joachim Loo, Stefan Wuertz
  • Patent number: 10168297
    Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 1, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ye Lu, Brett R. Goldsmith, Nicholas J. Kybert
  • Patent number: 10106835
    Abstract: In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized elements and techniques for producing the same are disclosed. In one embodiment, a sterilized element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ?80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized elements.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: October 23, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Nelli Steinke
  • Patent number: 10048059
    Abstract: Disclosed are systems and methods that enable determination of uncorrelated thickness of a working electrode and surface region optical constants in settings involving electrochemical processing at a working electrodes in a Piezoelectric Balance system, by simultaneous application of an Ellipsometer system, the working electrode optionally having a multiplicity of nanofibers that are oriented non-normally to a surface of said working electrode. Further disclosed is, simultaneous with said determinations, the monitoring of electrochemical processes at a piezoelectric balance working electrode driven by electrical energy applied between said working electrode and counter electrode.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: August 14, 2018
    Assignees: J. A. WOOLLAM CO., INC, THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Mathias M. Schubert, Tino Hofmann, John A. Woollam, Rebecca Y. Lai
  • Patent number: 10016550
    Abstract: A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: July 10, 2018
    Assignee: EASYDIAL, INC.
    Inventors: Renato Giordano, Rodney Corder
  • Patent number: 10002233
    Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: June 19, 2018
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Gary Hayter, Lei He, Mark K. Sloan, Benjamin J. Feldman
  • Patent number: 9999390
    Abstract: A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: June 19, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Huanfen Yao, Zenghe Liu
  • Patent number: 9986979
    Abstract: The present disclosure relates to a non-invasive and continuous biomedical detections and non-invasive and continuous monitoring methods and devices for extracting and analyzing interstitial fluid extracted non-invasively and continuously from the skin of a subject comprising non-invasively electroporating the skin using a non pulsed voltage in combination with a pulsed voltage and applying negative pressure.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: June 5, 2018
    Assignee: INVAFREE HMS, INC.
    Inventors: Abdeltif Essalik, André Dussault, JalalEddine Essalik
  • Patent number: 9976125
    Abstract: An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: May 22, 2018
    Assignee: Ikeda Food Research Co., Ltd.
    Inventors: Takako Yada, Koji Miyamoto, Michinari Honda
  • Patent number: 9927389
    Abstract: An electrochemical sensor for the detection and analysis of an analyte in a solution is disclosed. The electrochemical sensor has an electrically non-conductive support; a plurality of electrodes on the support, each electrode having a first surface and an opposite second surface, said first surface facing towards the support and the second surface facing away from the support. The plurality of electrodes includes a reference electrode, a counter electrode, and a working electrode. The working electrode has a reagent composition containing a reagent for detecting an analyte applied directly to the second surface of the working electrode.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: March 27, 2018
    Assignee: ARCH CHEMICALS, INC.
    Inventors: Touraj Rowhani, Steven Sungil Jang
  • Patent number: 9921182
    Abstract: Embodiments provide mercury detection systems and methods for detecting the presence of mercury ions in one or more samples. In a detection method, a sample and TPET2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of mercury ions in the channel is determined based on a comparison between the first and second electrical property values.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: March 20, 2018
    Assignees: Alveo Technologies Inc., The Regents of the University of California
    Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
  • Patent number: 9895713
    Abstract: A method, and an article made therefrom, of: contacting a substrate with a first solution of a first polyelectrolyte polymer to form a layer of the first polyelectrolyte polymer on the substrate; and contacting the layer of the first polyelectrolyte polymer with a second solution of a second polyelectrolyte polymer to form a layer of the second polyelectrolyte polymer on the layer of the first polyelectrolyte polymer. The first polyelectrolyte is a polyanion or polycation polymer. The second polyelectrolyte is a polyanion or polycation polymer of a charge opposite to that of the first polyelectrolyte polymer. At least one of the first solution or the second solution is an aggregate-forming solution comprising an ionic species having at least two discrete sites of a charge opposite to that of the polyelectrolyte polymer in the aggregate-forming solution.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: February 20, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Walter J. Dressick, Kathryn J. Wahl, Dmitri Y. Petrovykh, Nabil D. Bassim, Rhonda Michelle Stroud
  • Patent number: 9897566
    Abstract: The present invention relates to disposable test sensors having improved sample application and measuring properties and their uses for detection, preferably, quantitative measurement, of analyte in a liquid sample like blood. In particular, the invention provides for an electrochemical biosensor which has a thin-layer fluid chamber having funnel-like shape with a novel extra wide opening as sampling entrance and a vent opening at the tip of the chamber for air escape. The thin-layer fluid chamber provides a reservoir from which a sample fluid can be drawn into it through capillary action. The extra wide sampling entrance provided by the present invention can draw blood into the chamber through any part of the opening, thus it allows easy targeting the samples with small volume, picking up smeared samples and it is more tolerant to users who jam the tip of the sensor into users' finger.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: February 20, 2018
    Assignee: Changsha Sinocare Inc.
    Inventors: Xiaohua Cai, Hongli Che, Shaobo Li
  • Patent number: 9669408
    Abstract: A slight volume collector adapted to collect a sample liquid with slight volume and be assembled to a detecting device is provided. The slight volume collector includes a body and an extension part. The extension part extends outward from the body and protrudes from the body. The extension part has a through hole, and the through hole passes through the extension part and corresponds to the body. The sample liquid is adapted to be adhered to and arranged in the through hole due to capillarity, and a volume of the sample liquid is substantially equal to a capacity of the through hole.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: June 6, 2017
    Assignee: HTC Corporation
    Inventors: Sheng-Chieh Lin, Pin-Chung Sun, Yao-Ting Tseng, Shih-Jen Lu, Chung-Ju Wu, Chien-Lung Huang
  • Patent number: 9594044
    Abstract: The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: March 14, 2017
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Motonori Uchiyama, Takuo Kouno
  • Patent number: 9512458
    Abstract: Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: December 6, 2016
    Assignee: I-SENS, INC.
    Inventors: Gang Cui, Jae Hyun Yoo, Ju Yong Kim, Keun Ki Kim, Moon Hwan Kim, Hakhyun Nam, Geun Sig Cha
  • Patent number: 9453811
    Abstract: The invention provides a Bottom Contacted 2D-layer Device (BCD) for the determination of graphene doping and chemical sensing. The device can be made by transfer of high quality CVD grown graphene films onto n- or p-doped silicon substrates yielding Schottky barrier diodes. Exposure to liquids and gases change the charge carrier density in the graphene and as a result the electrical transport of the device is modulated. The changes can be easily detected and interpreted in the doping power of the adsorbent. This principle allows one to create a new type of chemical sensor platform exploiting the monolayer nature of graphene or other carbon material. The device benefits from facile fabrication and the result is a robust device which can investigate surface chemistry on monolayer materials.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: September 27, 2016
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Georg Stefan Duesberg, Hye-Young Kim
  • Patent number: 9399792
    Abstract: In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized diagnostic elements and techniques for the production of the same are disclosed. In one embodiment, a sterilized diagnostic element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized diagnostic element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ?80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized diagnostic elements.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: July 26, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Nelli Steinke
  • Patent number: 9383351
    Abstract: A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: July 5, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Roger Fleming
  • Patent number: 9354195
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: May 31, 2016
    Assignee: Intel Corporation
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Patent number: 9351676
    Abstract: An electrochemical sensor includes a base plate provided with a concave part formed on one of surfaces thereof, a fluid channel formed so that a bottom part of the concave part and the other one of the surfaces of the base plate are communicated with each other, a plurality of electrodes formed on the concave part; a reagent fixed on the electrodes, a cover which covers the concave part, and an air channel which causes the inside and outside of the concave part to be communicated with each other.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: May 31, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Yoshiharu Sato, Tadao Yamaguchi, Shinichi Watanabe, Yoshimitsu Matsuura
  • Patent number: 9303280
    Abstract: The invention relates to a glucose dehydrogenase showing an NADP/NAD activity ratio, namely the value obtained by dividing the enzyme activity value obtained by using NADP as a coenzyme by the enzyme activity value obtained by using NAD as a coenzyme, of not lower than 300, to a gene coding therefor, and to a transformant harboring that gene. The enzyme of the invention is very high in NADP specificity and can be suitably used, for example, for NADPH production, for coenzyme regeneration in enzymatic reduction reactions, and in biosensors for glucose concentration measurements.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: April 5, 2016
    Assignee: Kaneka Corporation
    Inventors: Shigeru Kawano, Yoshihiko Yasohara
  • Patent number: 9234864
    Abstract: A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 ?L. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 12, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Benjamin J. Feldman, James L. Say, Mark S. Vreeke
  • Patent number: 9234861
    Abstract: Provided are an electrode, an electrolysis cell, and an electrochemical analyzer that improve the long-term stability of analysis data. A working electrode, a counter electrode, and reference electrode are disposed in an electrolysis cell. The working electrode is obtained by forming a lead wire in a composite material having platinum or a platinum alloy as a base material, in which a metal oxide is dispersed, or in a laminated material obtained by laminating a valve metal and platinum such that the cross sectional crystal texture in the thickness direction of the platinum is formed in layers and the thickness of each layer of the platinum is 5 micrometers or less. The metal oxide is selected from among zirconium oxide, tantalum oxide, and niobium oxide, and the metal oxide content of the platinum or the platinum alloy is 0.005 to 1 wt % in terms of the zirconium, tantalum, or niobium metal.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: January 12, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroshi Kanemoto, Haruo Akahoshi, So Oguchi, Kenta Imai, Taku Sakazume, Hiroshi Yoshida
  • Patent number: 9194777
    Abstract: A filter test strip to filter and test a specimen in liquid includes a test element and a specimen filter assembly which is located on the test element and includes a filter cotton holding layer, a filter cotton layer and a cotton bonding layer. The filter cotton holding layer has a filter channel to allow the specimen in liquid to pass through. The filter cotton layer fills the filter channel. A gap is formed between the filter cotton holding layer and filter cotton layer. The cotton bonding layer is located below the filter cotton holding layer and bonded to the test element via an adhesive which masks the gap. Hence the specimen in liquid can be prevented from seeping out through the gap with passing through the filter cotton layer. Therefore, the specimen in liquid can fully be filtered by the filter cotton layer to enhance test accuracy.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: November 24, 2015
    Assignee: BIOPTIK TECHNOLOGY, INC.
    Inventors: Ya-Yuan Chang, Chin-Shan Lai, Chin-Chang Yang, Kun-Lieh Wu
  • Patent number: 9188585
    Abstract: A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: November 17, 2015
    Assignee: Robert Bosch GmbH
    Inventors: Sam Kavusi, Yi Wei Chen, Michael Chen, Christoph Lang
  • Patent number: 9175328
    Abstract: A new ferrous complex capable of being used as an electron transfer mediator for a glucose sensor, a biosensor, and the like, is provided, which measure a glucose concentration in blood, in which the new ferrous complex exchanges rapidly and smoothly an electron between an enzyme and electrode, is strongly absorbed into electrode, and is stable, so that the new ferrous complex allows excellent sensitivity of a glucose sensor to be maintained.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: November 3, 2015
    Assignees: Samsung Electronics Co., Ltd., Institute for Research & Industry Cooperation, PNU
    Inventors: Chulho Cho, Yoon-bo Shim, Jaegeol Cho