Enzyme Included In Apparatus Patents (Class 204/403.14)
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Patent number: 11940444Abstract: The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction.Type: GrantFiled: June 28, 2021Date of Patent: March 26, 2024Assignee: McMaster UniversityInventors: Carlos Filipe, John D. Brennan, Robert Pelton, Sana Jahanshahi-Anbuhi, Yingfu Li
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Patent number: 11872561Abstract: A system for stretching a polynucleotide structure includes a first electrode configured to generate an electrostatic force perpendicular to a surface of the first electrode and to apply the electrostatic force to the polynucleotide structure to pin an end region of the polynucleotide structure near the surface of the first electrode, and a second electrode configured to generate an electric force along an axial direction of the polynucleotide structure to stretch the polynucleotide structure along the axial direction of the polynucleotide structure into a fully extended form.Type: GrantFiled: March 12, 2021Date of Patent: January 16, 2024Assignee: Robert Bosch GmbHInventors: Karim Gadelrab, Mordechai Kornbluth, Jake Christensen, Christopher Johnson, Boris Kozinsky
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Patent number: 11852605Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.Type: GrantFiled: June 21, 2019Date of Patent: December 26, 2023Assignee: Trustees of Dartmouth CollegeInventors: Katherine A. Mirica, Lukasz K. Mendecki, Michael Ko, Zheng Meng, Robert M. Stolz, Aileen Eagleton
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Patent number: 11565320Abstract: The present invention relates to examination of characteristics of silver nano-clusters self-arranged by means of reduction of silver salt to silver nanoparticles by means of 2-mercapto-thioxanthone on DNA and BSA in short photo-illumination duration of 1 second.Type: GrantFiled: December 27, 2018Date of Patent: January 31, 2023Assignee: Yildiz Teknik UniversitesiInventors: Nergis Arsu, Eyup Metin, Gonul Saadet Batibay, Nur Sena Okten
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Patent number: 11541385Abstract: A device and a method of using the device for determining hematocrit in a whole blood sample. The device includes a first portion having an introducer, at least one fluid channel, a fluid actuator, and an analysis sensor and conductivity sensor disposed within the fluid channel. The second portion includes at least one well containing at least one material. The first portion and second portion are movable with respect to each other. The introducer is configured to transfer at least a portion of the material from the well in portion two into the fluid channel of portion one. The method includes measuring the resistance over substantially the entire portion of a whole blood sample and calculating an average hematocrit level of the whole blood sample based on the measured resistance.Type: GrantFiled: September 1, 2018Date of Patent: January 3, 2023Assignee: Qorvo US, Inc.Inventor: James Russell Webster
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Patent number: 11465915Abstract: A sensor control system of a food processing system includes a logic processor operatively coupled to an electrode. The logic processor is configured to receive a sensor signal from the electrode, the electrode configured to collect the sensor signal from water used within the food processing system, process the sensor signal to determine a chemical measurement of the water, and generate an electrochemical cleaning control signal for the electrode to interact with the water to electrochemically clean the electrode based upon a user input signal.Type: GrantFiled: July 31, 2018Date of Patent: October 11, 2022Assignee: SMARTWASH SOLUTIONS LLCInventors: James M. Brennan, Danny Elmer Lindstrom, Christopher Michael McGinnis, Eric Child Wilhelmsen
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Patent number: 11457840Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: GrantFiled: March 20, 2019Date of Patent: October 4, 2022Assignee: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
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Patent number: 11428664Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.Type: GrantFiled: September 7, 2015Date of Patent: August 30, 2022Assignee: Indian Institute of ScienceInventors: Vinay Kumar, Navakanta Bhat
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Patent number: 11254971Abstract: The present invention relates to a method and kit for amplifying and detecting a quantity of nucleic acid. The invention is particularly relevant to isothermal amplification techniques carried out on a flow based assay device. The amplified nucleic acid may be detected on the device using an optical read-out.Type: GrantFiled: December 28, 2020Date of Patent: February 22, 2022Inventor: Gustavo Andrés Cerda-Moya
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Patent number: 11225645Abstract: The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase, According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level.Type: GrantFiled: February 15, 2019Date of Patent: January 18, 2022Assignees: Ikeda Food Research Co., Ltd., PHC CorporationInventors: Hironori Omura, Hirokazu Sanada, Takako Yada, Tetsunari Morita, Mika Kuyama, Tokuji Ikeda, Kenji Kano, Seiya Tsujimura
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Patent number: 11180790Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: GrantFiled: May 13, 2020Date of Patent: November 23, 2021Assignee: Ascensia Diabetes Care Holdings AGInventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 11143595Abstract: A plasma spectroscopy analysis method includes a preliminary addition process in which a bonding agent that is an agent other than DMSA is added to the specimen collected from a living body to which meso-2,3-dimercaptosuccinic acid (DMSA) is administered, a concentration process in which the analyte heavy metal ions in the specimen at a vicinity of one of a pair of electrodes by applying a voltage to the pair of electrodes, and a detection process in which plasma is generated by applying a voltage to the pair of electrodes, and luminescence of the analyte metal ions caused by the plasma is detected.Type: GrantFiled: April 22, 2019Date of Patent: October 12, 2021Assignee: ARKRAY, Inc.Inventors: Tsuyoshi Takasu, Kojiro Honma
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Patent number: 11009479Abstract: A sensor for the detection of HbA1c in a sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and an anti-HbA1c antibody functionalized or chemically functionalized to a surface of an exposed portion of the working electrode.Type: GrantFiled: May 7, 2018Date of Patent: May 18, 2021Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Chung Chiun Liu, Alireza Molazemhosseini
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Patent number: 10867719Abstract: Disclosed are compositions of electroactive polymers (EAPs) having improved performance stability. In the EAP compositions, a cross-linked polymer is deposited onto the surface of the EAP by vapor-deposition methods. Upon contact with an aqueous solution (e.g., an aqueous electrolyte solution), the vapor-deposited polymeric network becomes a hydrogel that encapsulates the EAPs. By modulating precursors and vapor deposition conditions, the mesh size of the resultant hydrogel coatings can be controlled to accommodate the key species that interact with the EAPs.Type: GrantFiled: July 16, 2018Date of Patent: December 15, 2020Assignee: Massachusetts Institute of TechnologyInventors: Andong Liu, Karen K. Gleason, T. Alan Hatton, Xianwen Mao
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Patent number: 10866205Abstract: Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b).Type: GrantFiled: March 26, 2018Date of Patent: December 15, 2020Assignee: PHC Holdings CorporationInventors: Masaki Fujiwara, Shin Ikeda, Takahiro Nakaminami
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Patent number: 10852267Abstract: A biosensor electrode comprises comprising a porous structure comprising a plurality of metal ligaments and a plurality of pores; and at least one carbon nanotube structure embedded in the porous structure and comprising a plurality of carbon nanotubes joined end to end by van der Waals attractive force, wherein the plurality of carbon nanotubes are arranged along a same direction.Type: GrantFiled: October 25, 2017Date of Patent: December 1, 2020Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Hong-Ying Fu, Wen-Zhen Li
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Patent number: 10845335Abstract: An electrochemical tongue can be used for detection of metal ions. The reference electrode of the electrochemical tongue can be coated with a polymer. More than one reference electrode can be used, and the electrochemical tongue can be inserted into a cone penetrometer for portable, in situ analysis.Type: GrantFiled: March 16, 2018Date of Patent: November 24, 2020Assignee: University of MassachusettsInventors: Pradeep Kurup, Ramaswamy Nagarajan, Timothy Ponrathnam, Weeradech Kiratitanavit
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Patent number: 10791928Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.Type: GrantFiled: February 20, 2020Date of Patent: October 6, 2020Assignee: DexCom, Inc.Inventors: Peter C. Simpson, Robert J. Boock, Mark C. Brister, Monica A. Rixman, Kum Ming Woo, Lisa Nguyen, Seth R. Brunner, Arthur Chee, Melissa A. Nicholas, Matthew D. Wightlin, Jack Pryor, Dubravka Markovic
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Patent number: 10761044Abstract: A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.Type: GrantFiled: November 10, 2015Date of Patent: September 1, 2020Assignee: PHC HOLDINGS CORPORATIONInventors: Yoshifumi Takahara, Takahiro Nakaminami, Shin Ikeda
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Patent number: 10655160Abstract: A formaldehyde electrochemical sensor employing a formaldehyde sensitive assembly of formaldehyde dehydrogenase attached to graphene in fluid communication with a source of NAD+, and a method of measuring formaldehyde utilizing the sensor.Type: GrantFiled: August 31, 2015Date of Patent: May 19, 2020Assignee: Regents of the University of MinnesotaInventors: Tianhong Cui, Shota Sando
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Patent number: 10571424Abstract: The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.Type: GrantFiled: August 30, 2016Date of Patent: February 25, 2020Assignee: PHC HOLDINGS CORPORATIONInventors: Motonori Uchiyama, Takuo Kouno
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Patent number: 10537889Abstract: Disclosed are methods and systems concerning flow cells for sequencing a nucleic acid sample that may be characterized by the following components: (a) a substrate having an inner surface facing a library sequencing region, and an outer surface; (b) a plurality of a plurality of forward and reverse amplification primers immobilized over the inner surface and providing a nucleic acid library capture surface of the library sequencing region; (c) a plurality of electrodes disposed along the inner surface directly under at least some of the forward and reverse amplification primers, and configured to provide, when charged, an electric field through the library capture surface and into the library sequencing region; (d) electrical leads connected to the plurality of electrodes to permit the electrodes to be independently addressable; and (e) fluidic couplings configured to deliver a plurality of nucleic acid libraries to the flow cell during different time periods.Type: GrantFiled: December 30, 2014Date of Patent: January 21, 2020Assignee: ILLUMINA, INC.Inventors: Chenlu Hou, Byoungsok Jung, Yir-Shyuan Wu, Tarun Khurana
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Patent number: 10501770Abstract: Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or more biocompatible binders, one or more biocompatible mediators, an enzyme, an enzyme stabilizer, and a conductive material. The system includes a dispenser including a chamber to hold the enzymatic-ink and an applicator to apply the enzymatic ink dispensed from the chamber onto a target substrate.Type: GrantFiled: February 5, 2016Date of Patent: December 10, 2019Assignee: The Regents of the University of CaliforniaInventors: Joseph Wang, Amay Jairaj Bandodkar
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Patent number: 10478829Abstract: Collector compositions C for mineral flotation, which include at least one of a hydroxamic acid A, and/or a salt S of a hydroxamic acid A solubilized in a water-soluble organic solvent L, and processes for using same for recovering sulfide and/or oxide minerals in mineral flotation processes are provided herewith.Type: GrantFiled: November 22, 2016Date of Patent: November 19, 2019Assignee: Cytec Industries Inc.Inventors: Tarun Bhambhani, Jason Freeman, Devarayasamudram R. Nagaraj
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Patent number: 10413914Abstract: The present invention is directed to methods that can be used in the enrichment of metal sulfide ores in desired minerals in cases where the ores have sulfide-containing gangues. The method involves adding an oxidant to slurries prepared from the ores during, or immediately prior to froth flotation.Type: GrantFiled: January 25, 2013Date of Patent: September 17, 2019Assignee: Evonik Degussa GmbHInventors: Gerhard Arnold, Terry Brown, Ingo Hamann, Alan Hitchiner
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Patent number: 10327677Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: GrantFiled: December 8, 2011Date of Patent: June 25, 2019Assignee: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
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Patent number: 10324058Abstract: Embodiments of the invention provide an in-situ polymerization technique for creating a glucose sensor chemistry stack. An analyte sensor comprises a crosslinked polymer matrix in contact with an electrode. The crosslinked polymer matrix is formed by exposing ultraviolet (UV) light to a polymer matrix mixture comprising a plurality of hydroxyethyl methacrylate (HEMA) monomers, one or more di-acrylate crosslinkers, one or more UV photoinitiators, and an oxidoreductase. The oxidoreductase is covalently linked to the crosslinked polymer matrix. In typical embodiments, the oxidoreductase is a glucose oxidase-acrylate bioconjugate. In one or more embodiments, the analyte sensor apparatus further comprises a glucose limiting membrane positioned over the crosslinked polymer matrix.Type: GrantFiled: April 28, 2016Date of Patent: June 18, 2019Assignee: MEDTRONIC MINIMED, INC.Inventors: Ashwin K. Rao, Daniel E. Pesantez
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Patent number: 10246786Abstract: An inexpensive, easily renewable bioelectronic device useful for bioreactors, biosensors, and biofuel cells includes an electrically conductive carbon electrode and a bioelectronic interface bonded to a surface of the electrically conductive carbon electrode, wherein the bioelectronic interface includes catalytically active material that is electrostatically bound directly or indirectly to the electrically conductive carbon electrode to facilitate easy removal upon a change in pH, thereby allowing easy regeneration of the bioelectronic interface.Type: GrantFiled: June 9, 2016Date of Patent: April 2, 2019Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventors: Robert Mark Worden, Brian L. Hassler, Lawrence T. Drzal, IIsoon Lee
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Patent number: 10228341Abstract: A biosensor includes a plurality of electrodes including a working electrode, and a detection layer which is immobilized on the working electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the working electrode. The working electrode is in an open system.Type: GrantFiled: October 14, 2016Date of Patent: March 12, 2019Assignees: ARKRAY, Inc., Ultizyme International Ltd.Inventors: Koji Katsuki, Megumi Saeda, Junko Shimazaki
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Patent number: 10179927Abstract: The present invention provides a method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises (a) contacting the sample with an electrochemically active reporter, wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of resorufin and compounds of formula (I) as defined herein, under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism; (b) electrochemically determining the released redox active reporter moiety; and (c) determining the presence of the microorganism and, opType: GrantFiled: August 24, 2015Date of Patent: January 15, 2019Assignees: Nanyang Technological University, National University of SingaporeInventors: Jamie Hinks, Jing Ying Evelina Han, Say Chye Joachim Loo, Stefan Wuertz
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Patent number: 10168297Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.Type: GrantFiled: August 17, 2015Date of Patent: January 1, 2019Assignee: The Trustees of the University of PennsylvaniaInventors: Alan T. Johnson, Jr., Ye Lu, Brett R. Goldsmith, Nicholas J. Kybert
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Patent number: 10106835Abstract: In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized elements and techniques for producing the same are disclosed. In one embodiment, a sterilized element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ?80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized elements.Type: GrantFiled: July 25, 2016Date of Patent: October 23, 2018Assignee: Roche Diabetes Care, Inc.Inventors: Carina Horn, Nelli Steinke
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Patent number: 10048059Abstract: Disclosed are systems and methods that enable determination of uncorrelated thickness of a working electrode and surface region optical constants in settings involving electrochemical processing at a working electrodes in a Piezoelectric Balance system, by simultaneous application of an Ellipsometer system, the working electrode optionally having a multiplicity of nanofibers that are oriented non-normally to a surface of said working electrode. Further disclosed is, simultaneous with said determinations, the monitoring of electrochemical processes at a piezoelectric balance working electrode driven by electrical energy applied between said working electrode and counter electrode.Type: GrantFiled: August 11, 2016Date of Patent: August 14, 2018Assignees: J. A. WOOLLAM CO., INC, THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Mathias M. Schubert, Tino Hofmann, John A. Woollam, Rebecca Y. Lai
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Patent number: 10016550Abstract: A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment.Type: GrantFiled: April 7, 2015Date of Patent: July 10, 2018Assignee: EASYDIAL, INC.Inventors: Renato Giordano, Rodney Corder
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Patent number: 10002233Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.Type: GrantFiled: May 14, 2008Date of Patent: June 19, 2018Assignee: ABBOTT DIABETES CARE INC.Inventors: Gary Hayter, Lei He, Mark K. Sloan, Benjamin J. Feldman
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Patent number: 9999390Abstract: A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.Type: GrantFiled: October 17, 2013Date of Patent: June 19, 2018Assignee: Verily Life Sciences LLCInventors: Huanfen Yao, Zenghe Liu
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Patent number: 9986979Abstract: The present disclosure relates to a non-invasive and continuous biomedical detections and non-invasive and continuous monitoring methods and devices for extracting and analyzing interstitial fluid extracted non-invasively and continuously from the skin of a subject comprising non-invasively electroporating the skin using a non pulsed voltage in combination with a pulsed voltage and applying negative pressure.Type: GrantFiled: February 19, 2010Date of Patent: June 5, 2018Assignee: INVAFREE HMS, INC.Inventors: Abdeltif Essalik, André Dussault, JalalEddine Essalik
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Patent number: 9976125Abstract: An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained.Type: GrantFiled: April 25, 2017Date of Patent: May 22, 2018Assignee: Ikeda Food Research Co., Ltd.Inventors: Takako Yada, Koji Miyamoto, Michinari Honda
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Patent number: 9927389Abstract: An electrochemical sensor for the detection and analysis of an analyte in a solution is disclosed. The electrochemical sensor has an electrically non-conductive support; a plurality of electrodes on the support, each electrode having a first surface and an opposite second surface, said first surface facing towards the support and the second surface facing away from the support. The plurality of electrodes includes a reference electrode, a counter electrode, and a working electrode. The working electrode has a reagent composition containing a reagent for detecting an analyte applied directly to the second surface of the working electrode.Type: GrantFiled: September 20, 2013Date of Patent: March 27, 2018Assignee: ARCH CHEMICALS, INC.Inventors: Touraj Rowhani, Steven Sungil Jang
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Patent number: 9921182Abstract: Embodiments provide mercury detection systems and methods for detecting the presence of mercury ions in one or more samples. In a detection method, a sample and TPET2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of mercury ions in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: October 6, 2014Date of Patent: March 20, 2018Assignees: Alveo Technologies Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 9897566Abstract: The present invention relates to disposable test sensors having improved sample application and measuring properties and their uses for detection, preferably, quantitative measurement, of analyte in a liquid sample like blood. In particular, the invention provides for an electrochemical biosensor which has a thin-layer fluid chamber having funnel-like shape with a novel extra wide opening as sampling entrance and a vent opening at the tip of the chamber for air escape. The thin-layer fluid chamber provides a reservoir from which a sample fluid can be drawn into it through capillary action. The extra wide sampling entrance provided by the present invention can draw blood into the chamber through any part of the opening, thus it allows easy targeting the samples with small volume, picking up smeared samples and it is more tolerant to users who jam the tip of the sensor into users' finger.Type: GrantFiled: January 13, 2014Date of Patent: February 20, 2018Assignee: Changsha Sinocare Inc.Inventors: Xiaohua Cai, Hongli Che, Shaobo Li
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Patent number: 9895713Abstract: A method, and an article made therefrom, of: contacting a substrate with a first solution of a first polyelectrolyte polymer to form a layer of the first polyelectrolyte polymer on the substrate; and contacting the layer of the first polyelectrolyte polymer with a second solution of a second polyelectrolyte polymer to form a layer of the second polyelectrolyte polymer on the layer of the first polyelectrolyte polymer. The first polyelectrolyte is a polyanion or polycation polymer. The second polyelectrolyte is a polyanion or polycation polymer of a charge opposite to that of the first polyelectrolyte polymer. At least one of the first solution or the second solution is an aggregate-forming solution comprising an ionic species having at least two discrete sites of a charge opposite to that of the polyelectrolyte polymer in the aggregate-forming solution.Type: GrantFiled: March 6, 2014Date of Patent: February 20, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Walter J. Dressick, Kathryn J. Wahl, Dmitri Y. Petrovykh, Nabil D. Bassim, Rhonda Michelle Stroud
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Patent number: 9669408Abstract: A slight volume collector adapted to collect a sample liquid with slight volume and be assembled to a detecting device is provided. The slight volume collector includes a body and an extension part. The extension part extends outward from the body and protrudes from the body. The extension part has a through hole, and the through hole passes through the extension part and corresponds to the body. The sample liquid is adapted to be adhered to and arranged in the through hole due to capillarity, and a volume of the sample liquid is substantially equal to a capacity of the through hole.Type: GrantFiled: November 28, 2014Date of Patent: June 6, 2017Assignee: HTC CorporationInventors: Sheng-Chieh Lin, Pin-Chung Sun, Yao-Ting Tseng, Shih-Jen Lu, Chung-Ju Wu, Chien-Lung Huang
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Patent number: 9594044Abstract: The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.Type: GrantFiled: September 30, 2011Date of Patent: March 14, 2017Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Motonori Uchiyama, Takuo Kouno
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Patent number: 9512458Abstract: Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.Type: GrantFiled: October 24, 2008Date of Patent: December 6, 2016Assignee: I-SENS, INC.Inventors: Gang Cui, Jae Hyun Yoo, Ju Yong Kim, Keun Ki Kim, Moon Hwan Kim, Hakhyun Nam, Geun Sig Cha
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Patent number: 9453811Abstract: The invention provides a Bottom Contacted 2D-layer Device (BCD) for the determination of graphene doping and chemical sensing. The device can be made by transfer of high quality CVD grown graphene films onto n- or p-doped silicon substrates yielding Schottky barrier diodes. Exposure to liquids and gases change the charge carrier density in the graphene and as a result the electrical transport of the device is modulated. The changes can be easily detected and interpreted in the doping power of the adsorbent. This principle allows one to create a new type of chemical sensor platform exploiting the monolayer nature of graphene or other carbon material. The device benefits from facile fabrication and the result is a robust device which can investigate surface chemistry on monolayer materials.Type: GrantFiled: November 20, 2013Date of Patent: September 27, 2016Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Georg Stefan Duesberg, Hye-Young Kim
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Patent number: 9399792Abstract: In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized diagnostic elements and techniques for the production of the same are disclosed. In one embodiment, a sterilized diagnostic element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized diagnostic element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ?80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized diagnostic elements.Type: GrantFiled: June 11, 2012Date of Patent: July 26, 2016Assignee: Roche Diabetes Care, Inc.Inventors: Carina Horn, Nelli Steinke
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Patent number: 9383351Abstract: A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.Type: GrantFiled: July 15, 2014Date of Patent: July 5, 2016Assignee: Ascensia Diabetes Care Holdings AGInventor: Roger Fleming
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Patent number: 9351676Abstract: An electrochemical sensor includes a base plate provided with a concave part formed on one of surfaces thereof, a fluid channel formed so that a bottom part of the concave part and the other one of the surfaces of the base plate are communicated with each other, a plurality of electrodes formed on the concave part; a reagent fixed on the electrodes, a cover which covers the concave part, and an air channel which causes the inside and outside of the concave part to be communicated with each other.Type: GrantFiled: October 28, 2011Date of Patent: May 31, 2016Assignee: ARKRAY, Inc.Inventors: Yoshiharu Sato, Tadao Yamaguchi, Shinichi Watanabe, Yoshimitsu Matsuura
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Patent number: 9354195Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.Type: GrantFiled: December 12, 2013Date of Patent: May 31, 2016Assignee: Intel CorporationInventors: Noureddine Tayebi, Xing Su, Handong Li