Enzyme Included In Apparatus Patents (Class 204/403.14)
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Publication number: 20150001098Abstract: Disclosed are a blood sugar detecting method and a cartridge using same. A cartridge according to the present invention comprises: a blood receiving unit for receiving blood injected therein; a separation unit for separating the received blood into glucose and hemoglobin; a first measuring unit for measuring the concentration of the separated glucose; a second measuring unit for measuring the concentration of hemoglobin A1c (HbA1c) in the hemoglobin; and a third measuring unit connected to a second channel, for measuring the total concentration of hemoglobin. According to the present invention, both glucose providing short-term information on blood sugar and hemoglobin A1c providing long-term information on blood sugar can be detected by a single cartridge, thus increasing the efficiency of diabetes management.Type: ApplicationFiled: February 9, 2012Publication date: January 1, 2015Applicant: LG ELECTRONICS INC.Inventors: Yongju Yang, Seungyeon Song, Moosub Kim, Yunhee Ku
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Publication number: 20140374276Abstract: A physiological measurement system includes a biosensor providing a signal for a fluid sample. A processor determines a physiological parameter in the form of an analyte concentration using the signal from the biosensor. A network interface conveys data between the processor and a social network. The processor can transmit a query for analyte-data-request records to the social network, receive an indication of an analyte-data-request record from the social network, and transmit the determined analyte data or physiologic data to the social network in response to the indication. The processor can alternatively retrieve user credentials from a storage device, transmit the credentials and the analyte data to the social network, retrieve from the social network different-user response data corresponding to the transmission, and present an indication of the response data. Methods for processing analyte or physiologic data are also described.Type: ApplicationFiled: June 25, 2013Publication date: December 25, 2014Inventors: Brian GUTHRIE, David ELDER, Graeme PRINGLE, Damian Edward Haydon BASKEYFIELD
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Publication number: 20140374275Abstract: A glucose measurement system includes a display and a biosensor that provides a signal representative of a glucose level of a fluid sample. A processor determines glucose data values and a rate of change of blood glucose using the signal. The processor can determine a state band and a rate band using the values and rate, and display a state icon colored per the state band and a rate icon colored and shaped per the rate band. The processor does not display any other indication of the determined rate of change or of any of the stored glucose data values. The processor can also display a unified icon shaped per the rate of change, with a prevailing color determined using the values. The processor does not display any other indication of the determined rate of change or of any of the stored glucose data values. Corresponding methods are also described.Type: ApplicationFiled: June 25, 2013Publication date: December 25, 2014Inventors: Carlos Omar MORALES, Shawn Berven
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Publication number: 20140377789Abstract: The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to monitor disease progression or treatment.Type: ApplicationFiled: February 8, 2013Publication date: December 25, 2014Inventor: Piet Moerman
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Publication number: 20140378346Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.Type: ApplicationFiled: August 14, 2014Publication date: December 25, 2014Inventors: Yukio NAGASAKI, Tadahito TAKAHASHI, Kazunori KATAOKA, Fumiko ABOSHI, Miki KATO, Tomoko JOMURA, Hiroshi KOBAYASHI, Yoshinori KATSUYAMA, Masami NAKAMAE
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Publication number: 20140360873Abstract: A meter configured to perform a blood analysis is presented where the meter has a housing, the housing having an aperture configured to receive a body part of a user. The meter also having a plurality of light sources supported by the housing and a controller configured to control the plurality of light sources to indicate an operational status of the apparatus.Type: ApplicationFiled: January 9, 2013Publication date: December 11, 2014Inventors: Frank Richter, Ross Macarthur, Elizabeth Verity Wolseley-Hext, Joseph David Cowan, Lee Thomas Smith, David John Mills
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Patent number: 8906209Abstract: An electrochemical test sensor (10) for determining an analyte in a fluid sample, includes a base (12) and a second layer. The base (12) includes a plurality of electrodes (30,32), a working conductive lead (42) and a counter conductive lead (40) thereon. The electrodes include a working electrode (32) and a counter electrode (30). The second layer (20) assists in forming a channel (22) in which the channel includes a reagent therein. Auto-calibration information of the test sensor is performed by a plurality of auto-calibration segments (75) connected to one of the following: the working conductive lead (42), the counter conductive lead (40), or neither of the conductive leads, at least one of the plurality of auto-calibration segments (75a) being connected to the working conductive lead (42) and at least one of the plurality of auto-calibration segments (75b) being connected to the counter conductive lead (40).Type: GrantFiled: December 8, 2008Date of Patent: December 9, 2014Assignee: Bayer Healthcare LLCInventors: Harris A. Lieber, Joseph E. Perry
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Patent number: 8906211Abstract: Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.Type: GrantFiled: January 27, 2014Date of Patent: December 9, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Tianmei Ouyang, Zenghe Liu
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Publication number: 20140353154Abstract: Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.Type: ApplicationFiled: June 16, 2014Publication date: December 4, 2014Inventors: Kanchan A. Joshi, Ray Radtkey, Christian Valcke
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Patent number: 8900430Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.Type: GrantFiled: July 3, 2013Date of Patent: December 2, 2014Assignee: Panasonic Healthcare Holdings Co., LtdInventors: Hiroya Ueno, Junji Nakatsuka
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Publication number: 20140349005Abstract: Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.Type: ApplicationFiled: December 3, 2012Publication date: November 27, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Howard Katz, Kalpana Besar, Weiguo Huang
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Publication number: 20140339100Abstract: Various embodiments for systems and methods that allow for a more accurate analyte concentration with a biosensor by obtaining two calibration codes, one for batch calibration due to manufacturing variations and the other for time calibration due to measured physical characteristics of the fluid sample.Type: ApplicationFiled: May 17, 2013Publication date: November 20, 2014Applicant: LifeScan Scotland LimitedInventor: Michael MALECHA
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Publication number: 20140339078Abstract: Provided is a glucose sensor. The glucose sensor according to the present invention includes noble metal-graphene composites, and has high sensitivity and significantly excellent current flow as compared to titanium dioxide-graphene composites. In addition, the noble metal-graphene composite manufactured by aerosol spray pyrolysis serves as an improved glucose sensor having desirable sensitivity, stability, reproducibility, and selectivity.Type: ApplicationFiled: September 17, 2013Publication date: November 20, 2014Applicant: KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCESInventors: Hee Dong JANG, Han Kwon CHANG, Sun Kyung KIM, Ki Min ROH
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Publication number: 20140332407Abstract: The present disclosure relates to electro-optical sensors, to sensor kits and methods for detecting an analyte in a sample.Type: ApplicationFiled: May 13, 2014Publication date: November 13, 2014Applicant: Sony CorporationInventors: Michaela MAI, Ingeborg Hospach, Nadejda Krasteva, Gabriele Nelles
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Patent number: 8882978Abstract: Disclosed herein are a gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of glucose; a reagent composition for use in the determination of glucose; and a biosensor for use in the determination of glucose. An embodiment is a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide whose amino acid sequence comprises X1-X2-X3-X4-X5-X6, wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue.Type: GrantFiled: June 18, 2013Date of Patent: November 11, 2014Assignee: Ikeda Food Research Co., Ltd.Inventors: Takako Yada, Koji Miyamoto, Michinari Honda
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Publication number: 20140326600Abstract: Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrodes.Type: ApplicationFiled: September 11, 2012Publication date: November 6, 2014Applicant: NANOSELECT, INC.Inventors: Chunhong Li, David J. Ruggieri
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Publication number: 20140329254Abstract: The present invention relates to a biosensor using dual amplification of signal amplification by means of enzymes coupled with signal amplification by means of redox cycling, and to the use of a technology that maintains a slow reaction state between redox cycling materials without the use of redox enzymes, and induces quick chemical-chemical redox cycling. In addition, the present invention relates to a biosensor which obtains triple amplification by inducing electrochemical-chemical-chemical redox cycling, in addition to signal amplification by means of enzymes and signal amplification by means of chemical-chemical redox cycling.Type: ApplicationFiled: December 13, 2012Publication date: November 6, 2014Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATIONInventors: Hae Sik Yang, Muhamad Rajibul Akanda
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Publication number: 20140330100Abstract: Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Exemplary moieties include redox mediator molecules, crown ethers, catalysts, boric acids, carbohydrates, oligonucleotides, DNA or RNA aptamers, peptide aptamers, proteins such as enzymes and antibodies, quantum dots and nanoparticles, cells, cell organelles, or other cellular components. The density of functional groups or functional moieties on carbon nanostructure surfaces may also be controlled as well as the degree of surface hydrophilicity of the nanostructure.Type: ApplicationFiled: September 10, 2012Publication date: November 6, 2014Applicant: NANOSELECT, INC.Inventors: Chunhong Li, David J. Ruggieri
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Publication number: 20140322608Abstract: A method of graphitic petal synthesis includes a step of providing a flexible carbon substrate, such as that including carbon microfibers. The method further includes the step of subjecting flexible carbon substrate to microwave plasma enhanced chemical vapor deposition. The resulting synthesized graphitic petal structure may optionally be coated with PANI.Type: ApplicationFiled: February 14, 2014Publication date: October 30, 2014Applicant: PURDUE RESEARCH FOUNDATIONInventors: Jonathan Clay Claussen, Anurag Kumar, Timothy S. Fisher, Ronald G. Reifenberger, Guoping Xiong, David Benjamin Jaroch, David Marshall Porterfield
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Publication number: 20140305809Abstract: The present invention relates to mutants of the Penicillium amagasakiense glucose oxidase (GOx) enzyme which are of use for assaying glucose and to the development in particular of glucose electrodes and of biocells which use glucose as fuel.Type: ApplicationFiled: September 7, 2012Publication date: October 16, 2014Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIQUEInventors: Nicolas Mano, Olivier Courjean, Emilie Tremey, Sebastien Gounel
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Publication number: 20140305796Abstract: A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.Type: ApplicationFiled: April 15, 2014Publication date: October 16, 2014Inventors: MARK E. MEYERHOFF, BRUCE E. COHAN, QINYI YAN, BO PENG, ZVI FLANDERS
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Publication number: 20140299467Abstract: Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber.Type: ApplicationFiled: June 16, 2014Publication date: October 9, 2014Inventor: Yi Wang
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Patent number: 8852413Abstract: A biosensor, comprising an insulating base plate, an electrode system containing at least a working electrode and a counter electrode and formed on the insulating base plate, and a sample-supplying section formed on the electrode system, wherein the sample-supplying section has a reaction layer comprising: a first reaction layer formed on the electrode system and containing at least a redox enzyme into which pyrroloquinoline quinone (PQQ), flavin adenine dinucleotide (FAD), or flavin mononucleotide (FMN) is incorporated as a prosthetic group; and a second reaction layer formed by applying, onto the first reaction layer, a solution including a lipid decomposing enzyme.Type: GrantFiled: March 30, 2011Date of Patent: October 7, 2014Assignees: CCI Corporation, Ultizyme International Ltd.Inventors: Naohide Nishiwaki, Shoichi Miyamoto, Akitsugu Inagawa, Hironobu Murase
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Publication number: 20140291167Abstract: Various embodiments that allow for a more accurate analyte concentration by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic and sampling time so that the analyte concentration can be determined with greater accuracy with the specific sampling time point.Type: ApplicationFiled: December 28, 2012Publication date: October 2, 2014Applicant: LIFESCAN SCOTLAND LIMITEDInventor: Michael Malecha
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Publication number: 20140287445Abstract: A flavin-binding glucose dehydrogenase (FAD-GDH), which in addition to having high substrate specificity and adequate desirable heat stability, is suitable for efficient production, preferably using E. coli, yeast or molds and the like as host cells. The FAD-GDH has amino acid substitutions at positions equivalent to one or more locations selected from the group consisting of position 213, position 368 and position 526 in the amino acid sequence described in SEQ ID NO: 8. The FAD-GDH is acquired from a culture by inserting a gene encoding the FAD-GDH into host cells such as E. coli. A preferable example of the FAD-GDH is FAD-GDH, in which a signal peptide region present in an N-terminal region has been deleted from the amino acid sequence of Mucor-derived FAD-GDH, and which has the aforementioned amino acid substitutions. The FAD-GDH can be preferably used in clinical diagnosis.Type: ApplicationFiled: June 6, 2012Publication date: September 25, 2014Inventors: Ryoko Tajima, Kozo Hirokawa, Eriko Yoshihara, Yasuko Tanabe
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Publication number: 20140262777Abstract: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Abbott Point of Care Inc.Inventors: Tian-Xian Zhao, Glenn Martin, Kenneth Hardage, Steven R. Breeze, Stephen Snyder
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Publication number: 20140262776Abstract: This invention relates to mutagenized redox oxidase enzymes used to design enzyme electrodes with improved interference characteristics in the presence of mediator and oxygen in the assay. This recombinant modified enzyme has enhanced capability to transfer electrons to redox mediator instead of its natural electron acceptors such as O2, NAD, NADP, etc., which will improve the assay performance with less interference and higher sensitivity.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Abbott Point of Care Inc.Inventors: Glenn Martin, G. Bruce Collier, Dan Wang
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Publication number: 20140262778Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.Type: ApplicationFiled: May 30, 2014Publication date: September 18, 2014Applicant: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar G. Iyengar
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BIOSENSORS AND BIOSENSOR SYSTEMS WITH Mn2O3 CATALYST AS WELL AS METHODS OF MAKING AND USING THE SAME
Publication number: 20140251826Abstract: Biosensors and biosensor systems are disclosed that have manganese (III) oxide (Mn2O3)-based electrodes that can attenuate interference of a detection signal resulting from an analyte-relevant reaction caused by undesired reaction of interferents in a sample. Methods are also disclosed for making and using the same.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Applicant: Roche Diagnostics Operations, Inc.Inventors: Karl-Heinz Koelker, Arnulf Staib -
Publication number: 20140255959Abstract: Compositions, devices, kits and methods are disclosed for assaying cholesterol with a cholesterol oxidase mutant that has been modified at an amino acid residue involved in the active site. The cholesterol oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity.Type: ApplicationFiled: February 24, 2014Publication date: September 11, 2014Applicants: Ultizyme International, Ltd., Roche Diagnostics Operations, Inc.Inventors: Katsuhiro Kojima, Kazushige Mori, Sode Koji
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Patent number: 8828204Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: GrantFiled: August 22, 2011Date of Patent: September 9, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Fei Mao, Adam Heller
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Publication number: 20140248645Abstract: Compositions, devices, kits and methods are disclosed for assaying glucose with a glucose oxidase mutant that has been modified at an amino acid residue involved in the active site. The glucose oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity.Type: ApplicationFiled: February 24, 2014Publication date: September 4, 2014Applicants: Ultizyme International, Ltd., Roche Diagnostics Operations, Inc.Inventors: Katsuhiro Kojima, Kazushige Mori, Sode Koji
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Publication number: 20140246335Abstract: A technique and a sensor chip allowing determination of a hematocrit value of a blood sample in a short period of time with low cost are provided. A response current obtained by sweep of a voltage applied across a working electrode for determination and a counter electrode for determination included in a sensor chip is measured and a hematocrit value is derived based on followability of the response current to temporal change in swept applied voltage. Therefore, it is not necessary to stand by until oxidation reduction reaction of an oxidation reducing substance is stabilized for determining a hematocrit value as in a conventional method of determining a hematocrit value, and thus a hematocrit value of a blood sample can be determined in a short period of time. Since no oxidation reducing substance is necessary for determining a hematocrit value, a hematocrit value can be determined with low cost.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: Murata Manufacturing Co., Ltd.Inventors: Hideaki OOE, Jun TAKAGI, Kenji YOKOYAMA, Atsunori HIRATSUKA, Nobuyuki YOSHIDA, Noriko SASAKI
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Publication number: 20140246336Abstract: A technique allowing improved determination accuracy in quantifying a substance to be determined by lessening influence by a current component different from an oxidation current is provided. The oxidation current results from oxidation of a reducing substance generated through reaction between an enzyme and the substance to be determined. Current components are contained in a response current resulting from application of a determination potential, referenced to a counter electrode, to a working electrode. Since a conditioning potential higher than a determination potential is applied as a pulse to the working electrode, influence by a current component different from an oxidation current can be lessened. Thus, the response current can be measured in a stable manner and determination accuracy in quantification of a substance to be determined which is contained in a specimen can be improved.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: Murata Manufacturing Co., Ltd.Inventors: Hideaki OOE, Jun TAKAGI, Kenji YOKOYAMA, Atsunori HIRATSUKA, Nobuyuki YOSHIDA, Noriko SASAKI
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Patent number: 8823380Abstract: One or more charge pumps may be used to amplify the output voltage from a chemically-sensitive pixel that comprises one or more transistors. A charge pump may include a number of track stage switches, a number of boost phase switches and a number of capacitors. The capacitors are in parallel during the track phase and in series during the boost phase, and the total capacitance is divided during the boost phase while the total charge remains fixed. Consequently, the output voltage is pushed up.Type: GrantFiled: June 30, 2011Date of Patent: September 2, 2014Assignee: Life Technologies CorporationInventors: Peter Levine, Mark Milgrew, Todd Rearick
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MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING
Publication number: 20140243634Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.Type: ApplicationFiled: February 27, 2013Publication date: August 28, 2014Applicant: Medtronic MiniMed, Inc.Inventors: Ting Huang, Ashwin K. Rao, Rajiv Shah, Qingling Yang -
Publication number: 20140224653Abstract: Provided is a silver nanowire-containing composition for a biosensor strip, a biosensor strip comprising the same and its preparation method. The biosensor strip comprises a conductive pattern layer made of the silver nanowire-containing composition. With the aspect ratio of 50 to 500, the silver nanowire-containing composition has good dispersion and high conductivity, such that the biosensor strip comprising the same can have high stability and provide a more accurate and efficient detection.Type: ApplicationFiled: January 29, 2014Publication date: August 14, 2014Applicants: Industrial Technology Research Institute, K Cubic Research Co., Ltd.Inventors: Wen-Hsien Sun, Hou-Yu Lee, Shyh-Dar Ko, Ching-Chung Ko
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Publication number: 20140224671Abstract: A biosensor is a bio sensor for measuring concentrations of first and second substrates in a sample, including a sensor unit including an insulating base plate, an electrode over the insulating base plate, and a reaction layer over the electrode; a timing unit for measuring time; and a calculating unit, in which the reaction layer contains a first enzyme for converting the first substrate into the second substrate, and a second enzyme acting on the second substrate or the converted substance obtainable by further converting the second substrate, and the calculating unit calculates concentrations of the first and the second substrates in the sample, on the basis of a first current value detected in the sensor unit at a first time and a second current value detected in the sensor unit at a second time.Type: ApplicationFiled: March 15, 2013Publication date: August 14, 2014Applicant: TANITA CORPORATIONInventor: TANITA CORPORATION
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Publication number: 20140216931Abstract: A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.Type: ApplicationFiled: April 8, 2014Publication date: August 7, 2014Applicant: Abbott Diabetes Care Inc.Inventors: Adam Heller, Benjamin J. Feldman, Nicolas Mano, Yueh-Lin Loo
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Patent number: 8795490Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: GrantFiled: August 22, 2011Date of Patent: August 5, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Fei Mao, Adam Heller
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Publication number: 20140212947Abstract: The present invention relates to a bioelectrode including a cross-linkable organometallic polymer, and to a method for manufacturing same, and more particularly, to an electrode in which a nanostructure of the organometallic polymer is controlled to be used in bio fuel cells, biosensors, and the like. The electrode according to the present invention includes an organometal and further includes a self-assembling block copolymer and enzyme, and provides usages in bio fuel cells and biosensors.Type: ApplicationFiled: January 16, 2012Publication date: July 31, 2014Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Moon Jeong Park, Joung Phil Lee
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Publication number: 20140209481Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.Type: ApplicationFiled: January 25, 2013Publication date: July 31, 2014Applicant: Google Inc.Inventors: Nathan Pletcher, Brian Otis
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Publication number: 20140209460Abstract: A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ?S, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.Type: ApplicationFiled: April 1, 2014Publication date: July 31, 2014Applicant: Bayer HealthCare LLCInventors: Huan-Ping Wu, Sung-Kwon Jung
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Publication number: 20140209482Abstract: The method includes: acquiring data a related to a temperature of a blood sample on a sensor chip, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of an analyte in the blood sample, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: Panasonic Healthcare Co., Ltd.Inventor: Motonori UCHIYAMA
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Publication number: 20140202853Abstract: The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same.Type: ApplicationFiled: March 19, 2014Publication date: July 24, 2014Inventors: Yi Wang, Shridhara Alva Karinka, Benjamin J. Feldman
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Publication number: 20140202881Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.Type: ApplicationFiled: March 25, 2014Publication date: July 24, 2014Applicant: Bayer HealthCare LLCInventors: Dijia Huang, Steven C. Charlton, Suny J. George, Andrew J. Edelbrock
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Publication number: 20140202854Abstract: A method for measuring a target object in a sample by using an oxidase, wherein the influence of dissolved oxygen in the sample can be corrected, is provided. The method comprises: obtaining measurement values by causing the target object in the sample to react with the oxidase under different conditions of two or more types; and performing a correction based on the obtained two or more measurement values and a correction method preliminarily set so as to correct the influence of dissolved oxygen in the sample.Type: ApplicationFiled: March 25, 2014Publication date: July 24, 2014Applicant: ARKRAY, INC.Inventor: Hisashi Kaneda
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Patent number: 8784624Abstract: The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.Type: GrantFiled: July 11, 2007Date of Patent: July 22, 2014Assignee: Arkray, Inc.Inventors: Koji Katsuki, Konomu Hirao, Kenji Nagakawa, Masashi Okamoto, Yoshiaki Fujinawa
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Publication number: 20140197042Abstract: A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting.Type: ApplicationFiled: January 13, 2014Publication date: July 17, 2014Applicant: Northeastern UniversityInventors: Wenjun Zhang, Ming L. Wang
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Publication number: 20140197041Abstract: An amperometric biosensor is adapted for detecting concentration of a target analyte, and includes a detector and a plurality of sensing members connected electrically to form an input of the detector. Each sensing member includes an electrode unit including a working electrode with a biorecognition element disposed thereon for reaction with the target analyte, and a reference electrode. Each sensing member receives the target analyte, so as to bring the target analyte into contact with the working and reference electrodes. The detector provides a voltage to each electrode unit, so as to generate a current that flows through the target analyte and that is detected for subsequent concentration analysis of the target analyte.Type: ApplicationFiled: July 8, 2013Publication date: July 17, 2014Inventors: Tak-Shing CHING, Tai-Ping SUN, Jyun-Jhih WANG