Of Biological Material (e.g., Urine, Etc.) Patents (Class 205/792)
  • Patent number: 11561216
    Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: January 24, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Jason Robert Hyde, James Anthony Clarke, Gaëlle Anne-Leonie Andreatta
  • Patent number: 11505827
    Abstract: Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 22, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Timothy Geiser, Randall Davis, Roger Chen
  • Patent number: 11486849
    Abstract: The present disclosure provides a system for measuring a property of a sample comprising: a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a difference identity to generate a sinusoidal signal with an amplitude proportional to the phase difference; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: November 1, 2022
    Assignee: Trividia Health, Inc.
    Inventor: Steven V. Leone
  • Patent number: 11486884
    Abstract: The invention relates to methods for the diagnosis of ischemia or ischemic tissue damage, methods for predicting the progression of ischemia in a patient having suffered an ischemic event, for determining the prognosis of a patient having suffered an ischemic event and for determining the risk that a patient suffering from stable coronary disease suffers a recurrent ischemic event based on the detection of the levels of glycosylated Apo J. The invention relates as well to a method for the determination of glycosylated Apo J in a sample.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 1, 2022
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SAINT PAU
    Inventors: Lina Badimon Maestro, Judit Cubedo Ràfols, Teresa Padró Capmany
  • Patent number: 11486842
    Abstract: Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: November 1, 2022
    Assignee: NanoDX, Inc.
    Inventors: Farhad Khosravi, David Bastable, Sergey A. Dryga
  • Patent number: 11467069
    Abstract: The sampling chip dividing instrument includes: a main body block; a space that is provided inside the main body block, has an opening leading to an outer surface of the main body block, and fits in and contains the cut portion of the sampling chip through the opening; and an surrounding portion that is provided outside the space at a periphery of the opening, and receives a sample scattered from a break portion of the sampling chip divided near the opening.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: October 11, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Ippei Takauchi, Shinobu Kudoh
  • Patent number: 11434473
    Abstract: The present invention takes the glucose oxidase GOD from Aspergillus niger as the mutation template to obtain the glucose oxidase GOD mutants with improved catalytic efficiency and thermal stability by site directed mutagenesis. The specific activity of the mutant of the present invention is 66% higher than that of the wild type GOD; the enzyme activity of the mutant of the present invention is 13.6 times higher than that of the wild type after being treated at 70° C. for 10 min; and the enzyme activity of the mutant of the present invention is 29.4 times higher than that of the wild type after being treated at 80° C. for 2 min.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: September 6, 2022
    Inventors: Bin Yao, Huiying Luo, Tao Tu, Huoqing Huang, Xiaoyun Su, Yaru Wang, Yingguo Bai, Yuan Wang, Kun Meng
  • Patent number: 11355772
    Abstract: Devices powered by fuel cells can be operated for extended durations when the fuel cells are adapted to extract the necessary reactants for generating power from the surrounding environment and when the concentration of reactants in that environment is maintained at a sufficient level by interaction between the environment and a reactant-enriched atmosphere.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: June 7, 2022
    Assignee: CBN Nano Technologies Inc.
    Inventors: James F. Ryley, III, Robert A. Freitas, Jr.
  • Patent number: 11353417
    Abstract: Methods, devices, and systems are disclosed for the determination and logging of risk factor parameters associated with a sample, in association with the measurement of a concentration of an analyte in the sample. The methods, devices, and systems provide for applying an input signal to a sample via an electrode. The input signal has at least one excitation. The methods, devices, and systems further provide for measuring an output signal responsive to the input signal. The methods, devices, and systems further provide for determining a concentration of an analyte within the sample based on the output signal, and determining at least one risk factor parameter associated with at least one species in the sample other than the analyte.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 7, 2022
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventor: Huan-Ping Wu
  • Patent number: 11340190
    Abstract: Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof. Before explaining at least one embodiment of the inventive concept(s) in detail by way of exemplary drawings, experimentation, results, and laboratory procedures, it is to be understood that the inventive concept(s) is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings, experimentation and/or results.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: May 24, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Kevin Horan
  • Patent number: 11320350
    Abstract: Methods of agglutinating and separating erythrocytes, by which erythrocytes can be instantaneously agglutinated into a sufficient size in a blood sample and completely separated from the blood sample; and a hemagglutination reagent are provided. The method of agglutinating erythrocytes according to the present invention includes adding a solution containing a cholic acid-based surfactant and an acid to a blood sample. The method of separating erythrocytes according to the present invention includes separating the erythrocytes agglutinated by the above-described method of the present invention. The hemagglutination reagent according to the present invention contains a cholic acid-based surfactant and an acid.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: May 3, 2022
    Assignee: DENKA COMPANY LIMITED
    Inventors: Shino Muramatsu, Daisuke Kato, Tomohiro Hattori
  • Patent number: 11299781
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and insert-ing the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: April 12, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Randall Davis, Roger Chen
  • Patent number: 11185863
    Abstract: In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing (10, 30) and an actuator (50). The housing includes a receiving chamber (32). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber (52) configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 30, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Matthias Irmscher, Toon Hendrik Evers, Stefan Johannes Hendrikus Toonen, Marlieke Joan Overdijk, Harma Martine Feitsma, Thomas Johannes Van Gijsel, Wilbert Hendrik Bouwman, Eveline Catharina Anna Clasina Den Biezen-Timmermans, Willem-Jan Arend De Wijs
  • Patent number: 11105763
    Abstract: A method includes steps of: applying a first voltage signal on a blood sample so as to obtain a preliminary value regarding an analyte in the blood sample; applying on the blood sample, a second voltage signal that includes cycles of a pulse and that has a voltage value alternating between high and low levels; measuring a physical quantity resulting from application of the second voltage signal on the blood sample at a time point in one of the cycles of the pulse of the second voltage signal so as to generate a calibration value; and calibrating the preliminary value based on the calibration value so as to obtain a calibrated value of the analyte in the blood sample which serves as a result of measurement of the analyte.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 31, 2021
    Assignee: HEALTH & LIFE CO., LTD.
    Inventors: Meng-Yi Lin, Po-Han Chen, Pei-Chen Chang
  • Patent number: 11088742
    Abstract: Disclosed is an electronic device comprising: a touch screen display; a battery; a plurality of antenna elements arranged in order to perform beamforming for directional wireless communication; a first wireless communication circuit configured to provide, through the antenna elements, first wireless communication having a first coverage; a second wireless communication circuit configured to provide second wireless communication having a second coverage greater than the first coverage; and a processor connected to the display, the battery, the first wireless communication circuit, and the second wireless communication circuit, wherein the processor stores instructions for determining whether an external device is close to the electronic device by using the first wireless communication circuit, enabling at least one antenna element, rather than all the antenna elements, among the plurality of antenna elements, and transmitting data to the external device by using the second wireless communication circuit and th
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 10, 2021
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hyun Kee Min, Sun Key Lee, Jung Hun Lee, Tae Hun Lim, Min Whoa Hong, Choun Jong Nam, Sung Hee Lee
  • Patent number: 10983086
    Abstract: Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: April 20, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Kevin Horan
  • Patent number: 10968481
    Abstract: Chemically-sensitive field effect transistors for biosensor chips and system are disclosed. The itransisitors have a multi-layered structure for performing a set of measurements of a biological reaction involving a binding event for one or more biological analytes that may be label-free. The multilayer structure includes a first insulating layer above a substrate layer and a source electrode and a drain electrode disposed positioned over the first insulating layer; a second insulating layer above the first insulating layer and proximate the source and drain electrodes forming side wall members of a well for a fluid comprising the analytes; a 2D graphene layer forming a channel between source and drain electrodes; a solution gate, formed by fluid flowed over the channel, configured to enable determining differences between one or more sample I-Vg curves having a shifted and changed shape relative to a reference curve; embodiments may include ion-selective membranes and/or ion getters.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: April 6, 2021
    Assignee: Cardea Bio, Inc.
    Inventors: Pieter van Rooyen, Mitchell Lerner, Paul Hoffman, Brett R. Goldsmith
  • Patent number: 10908113
    Abstract: A liquid-sensing apparatus includes a substrate, partitions, and independent sensors. The partitions are disposed on the substrate for separating several housing spaces in order to respectively house a to-be-detected liquid, wherein each of the housing spaces has a bottom, a closed sidewall, and an open top, and thus the to-be-detected liquid may be dripped from the top of the housing space. The independent sensors are respectively formed at the bottom of different housing spaces, wherein the independent sensors respectively include different sensing material layers, and surfaces of the different sensing material layers have nanoholes.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: February 2, 2021
    Assignee: Industrial Technology Research Institute
    Inventors: Jui-Chin Chen, Wen Wang, Pei-Jer Tzeng
  • Patent number: 10900909
    Abstract: A transmittance based system/kit for point-of-care quantification of biomarker samples includes a stage supporting a detection unit, an optical transmittance unit and a signal processing unit. The detection unit comprising reactive substrate is capable of undergoing a specific biomarker sample interactive reaction and generating a quantifiable optical signal proportional to the concentration of the said biomarker sample wherein the intensity of the color varies with the concentration of the analyte in the bio-sample. The optical transmittance unit, comprises a sample stage integrated with the light source and a photodetector, converting quantifiable optical signal transmitted through the reagent coated substrate detection unit to electrical signals, a signal processing unit connected to the said optical transmittance unit transduces the analogue electrical signal into the digital display signal.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: January 26, 2021
    Assignee: INDIAN INSTITUTE OF TECHNOLOGY, GUWAHATI
    Inventors: Dipankar Bandyopadhyay, Nilanjan Mandal, Satarupa Dutta
  • Patent number: 10842421
    Abstract: A sensing device for sensing ion concentration of a solution, including a first substrate, a second substrate, a sensing layer, and two electrodes. The material of the first substrate includes cellulose. The second substrate is located on the first substrate. The sensing layer is located on the second substrate. The two electrodes are separately disposed on the sensing layer to expose the sensing layer and bring a solution in contact with the sensing layer so as to measure the resistance value of the solution and convert the resistance value into the ion concentration of the solution.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: November 24, 2020
    Assignee: Winbond Electronics Corp.
    Inventors: Ming-Hung Hsieh, Yu-Hsuan Ho, Ming-Chih Tsai, Yen-Jui Chu
  • Patent number: 10823740
    Abstract: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values for the binding of lectin of such proteins in healthy or disease states.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: November 3, 2020
    Assignee: Drexel University
    Inventors: Timothy M. Block, Mary Ann Comunale, Anand Mehta
  • Patent number: 10802032
    Abstract: Methods and materials are disclosed for evaluating head brain injuries that do not involve blood loss or skull fractures, such as possible concussions. These methods and materials involve bioreagents (such as monoclonal antibodies, single-stranded DNA or RNA, etc.) affixed to computer-readable devices handled by electronic readers that can interact with portable computers (such as laptops, pads or tablets, smart phones, etc.). The bioreagents will detect the presence and concentration of at least two metabolites that are released by mitochondria in response to cellular damage. Additional bioreagents may be included, for detecting and quantifying other damage-associated molecular patterns (DAMP's). When used along with cognitive, reasoning, and/or response tests, this type of analysis can help non-physicians assess the severity of, and proper responses to, head traumas that otherwise are difficult or impossible to reliably evaluate.
    Type: Grant
    Filed: January 11, 2014
    Date of Patent: October 13, 2020
    Inventor: Barry W Festoff
  • Patent number: 10640801
    Abstract: Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such as sugars (glucose) or glycated proteins (HgbA1c).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 5, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: XiuJun Li, Gilberto Henao-Pabon
  • Patent number: 10613050
    Abstract: A bio sensor a method of sensing for the bio sensor are provided. The bio sensor includes an electrode array. The electrode array includes an enzyme electrode for measuring a target material, a power driver for providing a voltage to the electrode array, and a processor for controlling the power driver to alternately provide a negative voltage and a positive voltage to the electrode array, and for controlling the power driver to provide a measurement voltage for measuring the target material to the electrode array after the alternating voltage is provided.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: April 7, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Youn-joo Song, Seong-je Cho, Kwang-bok Kim, Young-jae Oh, Jae-geol Cho, Hyoung-seon Choi
  • Patent number: 10605757
    Abstract: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes, and a driving power terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: March 31, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Yoshinobu Tokuno
  • Patent number: 10575767
    Abstract: A method for monitoring an analyte within the body of a patient, an analyst sensor, and an analyte monitoring apparatus are presented here. In accordance with certain embodiments, the method for monitoring an analyte within the body of a patient includes implanting an analyte sensor at a sensor placement site in the patient. The analyte sensor includes a reference electrode, a counter electrode, a primary working electrode having a first structure, and an auxiliary working electrode having a second structure different from the first structure. The method includes communicating a primary signal from the primary working electrode and an auxiliary signal from the auxiliary working electrode to a processor. Further, the method includes monitoring the primary signal and the auxiliary signal with the processor to characterize a change in a physiological characteristic at the sensor placement site.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 3, 2020
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Anuj M. Patel, Zachary Decke, Bradley C. Liang
  • Patent number: 10520461
    Abstract: The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 31, 2019
    Assignee: PHC HOLDINGS CORPORATION
    Inventor: Masaki Fujiwara
  • Patent number: 10436775
    Abstract: This disclosure describes an electric-field imaging system and method of use. In accordance with implementations of the electric-field imaging system, a fluid sample can be placed on top of a pixel-based impedance sensor. An image of the target analytes can be created immediately afterwards. From this image, computer imaging algorithms can determine attributes (e.g., size, type, morphology, volume, distribution, number, concentration, or motility, etc.) of the target analytes. The electric-field imaging sensor can be used for a variety of agglutination or agglomeration assays.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 8, 2019
    Assignee: MAXIM INTEGRATED PRODUCTS, INC.
    Inventors: Ronald B. Koo, Henry Grage
  • Patent number: 10416112
    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or dis
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: September 17, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Chiu Tai Andrew Wong, Todd Rearick, John Donohue
  • Patent number: 10379078
    Abstract: A biosensor includes a transistor and a reactive electrode. The transistor has a source, a drain and a gate surface disposed therebetween. The reactive electrode is spaced apart from the gate surface of the transistor, has a receptor immobilized thereon for specific binding with an analyte in a liquid sample, and is configured to contact the liquid sample together with the gate surface of the transistor.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 13, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Yu-Lin Wang, Jen-Inn Chyi, Chia-Ho Chu, Indu Sarangadharan
  • Patent number: 10379051
    Abstract: According to one embodiment, the illumination device includes a lighting unit and a control unit. The lighting unit emits light at the intensity to be emitted toward the region to be irradiated in a two-dimensional region of a measurement device. The measurement device acquires optical information and biochemical information and/or electrical information for an object corresponding with positional information. The control unit determines the region to be irradiated and the intensity to be emitted, based on the biochemical or electrical information by the measurement device, the positional information of them, and the threshold conditions predetermined, and controls the irradiation of the lighting unit depending on them.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: August 13, 2019
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Kaita Imai, Shouhei Kousai
  • Patent number: 10369568
    Abstract: A micro flow device (11, 71) for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts (23, 81). The posts are spaced across the width of an expanded collection chamber region (17, 75) in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, being curved in cross-sections, e.g. circular or tear-drop shaped, and are randomly arranged so as to disrupt streamlined flow. The device is oriented so that its lower surface is aligned at about 45° to the horizontal. Sequestering agents, such as Abs, which are attached to surfaces of the collection region via a hydrophilic coating, preferably a permeable hydrogel containing isocyanate moieties, are highly effective in capturing cells or other targeted biomolecules while the remainder of the liquid sample exits horizontally.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: August 6, 2019
    Assignee: BIOCEPT, INC.
    Inventors: Zhongliang Tang, Ram Bhatt, Pavel Tsinberg
  • Patent number: 10359390
    Abstract: A method is disclosed for determining analyte concentration that includes applying a first electrical potential excitation pulse to a body fluid sample in an analyte sensor, and a first current response of the body fluid sample to the first pulse is measured. A second excitation pulse is applied to the body fluid sample in the analyte sensor, and a second current response of the body fluid sample to the second pulse is measured. An analyte level in the body fluid sample is determined by compensating for sources of error based on the first current response to the first pulse.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: July 23, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: David W. Burke, Michael Marquant, Nigel A. Surridge
  • Patent number: 10316354
    Abstract: A two-electrode detection system having target substrates including nucleic acids, proteins, and/or small molecules on specifically defined regions of a single surface. The spatial distribution of the target substrate on the surface allows for more accurate substrate interactions and analysis. Additionally, the detection system of the present invention allows for patterning of different target substrates, thereby affording more accurate analysis of multiple substrate targets.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: June 11, 2019
    Assignee: California Institute of Technology
    Inventors: Ariel L. Furst, Michael G. Hill, Natalie B. Muren, Jacqueline K. Barton
  • Patent number: 10260093
    Abstract: Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: April 16, 2019
    Assignees: GENIA TECHNOLOGIES, INC., LIFE TECHNOLOGIES CORPORATION
    Inventors: Timothy Geiser, Randall Davis, Roger Chen
  • Patent number: 10157725
    Abstract: Some embodiments are directed to an electron microscopy sample support including: a support member; and a metal foil including a porous region. The support member is configured to give structural stability to the metal foil, and the porous region of the metal foil is configured to receive an electron microscopy sample. Also disclosed is a method of manufacturing such an electron microscopy sample support, a method of imaging using such an electron microscopy sample support and an apparatus operable to perform such imaging. The disclosed microscopy specimen support reduces particle motion and/or sample charging in electron microscopy, and thus improve information available from electron micrographs.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: December 18, 2018
    Assignee: UNITED KINGDOM RESEARCH AND INNOVATION
    Inventors: Lori A. Passmore, Christopher J. Russo
  • Patent number: 10139360
    Abstract: The present invention provides an automatic encoding device including a first electrode, a second electrode, and a third electrode. The first electrode and the second electrode are connected through a connecting point, so that an electric parameter between the first electrode and the second electrode changes according to a parameter needing to be corrected. The present invention further provides a method for applying the automatic encoding device to various biosensors and a method for manufacturing the automatic encoding device. Positions and the number of contacts for connecting the automatic encoding device and a detection system are fixed. Therefore, connection sites on the detection system are effectively utilized. On the other hand, the automatic encoding device in the present invention can provide different parameter information by only changing the positions of the connecting points on the electrodes, the process is simple and stable, and the probability of human errors is reduced.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: November 27, 2018
    Assignee: LEADWAY (HK) LIMITED
    Inventors: Tao Liu, Huanxi Ge, Chia-Lin Wang, Yun Ye
  • Patent number: 10125384
    Abstract: The present invention relates to a stabilizing composition useful for improving the stability of reagent for redox reaction, and a reagent composition for redox reaction having an improved stability. The reagent composition for redox reaction can be applied for a reagent for electrochemical biosensor.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: November 13, 2018
    Assignee: I-SENS. INC.
    Inventors: Sung-Kwon Jung, Moon Hwan Kim, Eun Hye Im, Myeongho Lee, Ung Ki Lee, Geun Sig Cha, Hakhyun Nam
  • Patent number: 10067086
    Abstract: A method recalibrates in situ a comparison electrode integrated into an electrochemical system. The electrochemical system includes a working electrode, a counter electrode, and an electrolyte. The method includes verifying a potential of the comparison electrode relative to the working electrode or to the counter electrode in situ, detecting whether there is a drift in the potential of the comparison electrode relative to a potential plateau for which the comparison electrode was functionalized or designed, and when the drift is detected, recalibrating the comparison electrode in situ.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: September 4, 2018
    Assignee: RENAULT s.a.s.
    Inventors: Sylvie Genies, Melanie Alias, Sylvain Leirens, Angel Zhivkov Kirchev
  • Patent number: 10047393
    Abstract: Embodiments of the invention include a method for fabricating a semiconductor device, the resulting structure, and a method for using the resulting structure. A substrate is provided. A hard mask layer is patterned over at least a portion of the substrate. Regions of the substrate not protected by the hard mask are doped to form a source region and a drain region. The hard mask layer is removed. A dielectric layer is deposited on the substrate. An insulative layer is deposited on the dielectric layer. A nano-channel is created by etching a portion of the insulative layer which passes over the source region and the drain region.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: August 14, 2018
    Assignee: International Business Machines Corporation
    Inventor: Effendi Leobandung
  • Patent number: 10022077
    Abstract: On-body units are provided and include a transcutaneous analyte sensor, electronic circuitry electrically coupled to the sensor, and an on-body housing having electrical contacts disposed thereon. The on-body housing comprises a substantially flat surface and a curved and convex surface opposite the substantially flat surface. Systems and methods including the on-body units are also provided. Methods for performing continuity measurements using on-body units are also provided. The methods include positioning an on-body unit (OBU) on a skin of a subject, contacting a continuity test instrument to the OBU; and performing a continuity measurement with the continuity test instrument. An AC signal may be provided across two electrical contacts, or a DC signal may be provided across two electrical contacts in opposite directions for the same amount of time. The measurement may be performed with one electrical contact, or with isolated electrical contacts.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: July 17, 2018
    Assignee: ABBOTT DIABEETES CARE INC.
    Inventor: Daniel M. Bernstein
  • Patent number: 10006881
    Abstract: An electrochemical gas sensor having an electrode with a catalyst distributed on a porous surface is described. The porous surface can be a polytetrafluoroethylene tape. Alternate embodiments include layered or stacked electrodes.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: June 26, 2018
    Assignee: Life Safety Distribution AG
    Inventors: Keith Francis Edwin Pratt, John Chapples, Martin Geoffrey Jones
  • Patent number: 9983160
    Abstract: An electrode array for the cyclic reduction and oxidation of a redox species in an electrolyte, wherein both electrodes are disposed on an insulating substrate and connected to a counter electrode for the application of a voltage, comprising: 1) a control electrode for reacting the redox species for cyclic electron transport between the electrodes: and b) a collector electrode disposed opposite the control electrode, wherein a layer structure composed of a second insulator and a charge transfer mediator disposed thereon is additionally disposed on the side of the collector electrode located opposite the insulating substrate for reacting the redox species. Two methods for operating the electrode array are disclosed.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: May 29, 2018
    Assignee: Forschungszentrum Juelich GmbH
    Inventors: Dirk Mayer, Yaqing Liu, Andreas Offenhaeusser
  • Patent number: 9952149
    Abstract: Methods, systems, and computer readable media for determining physical properties of a specimen in a portable point of care device are disclosed. According to one aspect, a method includes placing a specimen onto an active surface that includes a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end and generating an actuation force in proximity to the micropost array that compels at least some of the microposts to exhibit motion. The method further includes detecting light that is emitted by an illumination source and interacts with the active surface while the at least some microposts exhibit motion in response to the actuation force, measuring data that represents the detected light interacting with the active surface, and determining at least one physical property of the specimen based on the measured data.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: April 24, 2018
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Richard Superfine, Bruce J. Oberhardt, Richard Chasen Spero, Michael Richard Falvo, Briana Lee Fiser, Russell Morton Taylor, II, Robert Michael Judith
  • Patent number: 9944981
    Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: April 17, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jonathan Rothberg, Wolfgang Hinz, John Davidson, Antoine van Oijen, John Leamon, Martin Huber
  • Patent number: 9933385
    Abstract: A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: April 3, 2018
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Jing Lin, Fu Hsiung Tsai, Huan-Ping Wu, Nicole D Ellis, Henry C Arndt
  • Patent number: 9832080
    Abstract: The present invention provides a method for commissioning of nodes of a network. The method comprises the steps of (S10) receiving, at a first node (30a) of the network, at least one indication message including identification information of a second node (30b) of the network; (S20) receiving, at the first node (30a), parameter information indicating a parameter sensed with at least one parameter sensor associated with the first node (30a); (S30) determining whether the at least one indication message and the parameter information temporarily correlate; and (S40), if a correlation is determined, adding correlation information about the second node (30b) to a register table of the first node (30a).
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: November 28, 2017
    Assignee: PHILIPS LIGHTING HOLDING B.V.
    Inventors: Engel Johannes Knibbe, Cornelis Antonius Verbakel, Eric Johannus Hendricus Cornelis Maria Nieuwlands
  • Patent number: 9743871
    Abstract: In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: August 29, 2017
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Sebastian Bohm, Robert J. Boock, Matthew D. Wightlin, Huashi Zhang
  • Patent number: 9734361
    Abstract: It is an object to provide an information recording medium with which information symbols can be suitably read. This information recording medium comprises a sheet-form member, a plurality of information symbols that are displayed on the surface of the sheet-form member and each have the same information, and an edge line that is provided at one end and/or the other end of the sheet-form member and allows an information reading device which reads the information symbols to recognize the end of the sheet-form member.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 15, 2017
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Tooru Aoki, Seiji Kikuchi, Mitsuteru Fujimoto
  • Patent number: 9724037
    Abstract: A wearable device includes a main body, a support portion, an electrode assembly, and a processor. The main body can be worn by a user. The support portion is secured to the main body and faces the user. The electrode assembly is secured to the support portion, and includes two electrode arrays and a plurality of carbon nanotubes arranged in arrays. Each electrode array includes arranged electrodes electrically connected to each other. The electrodes of each electrode array include at least two first electrodes each electrically connected to one carbon nanotube. The carbon nanotubes electrically connected to the two electrode arrays are alternatively arranged on the support portion and spaced from each other to form a detecting surface. The processor detects a resistance value of each electrode assembly, and determines an amount of the perspiration corresponding to the detected resistance value.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 8, 2017
    Assignee: HON HAI PRECISION INDUSTRY CO., LTD.
    Inventor: Jen-Tsorng Chang