Abstract: The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.

Abstract: The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

Abstract: The present disclosure provides a package for a medical device containing a cavity for receiving the medical device, a first closure having a sealed portal therein and a second closure adjacent the first closure.

Abstract: The invention is a product and a process wherein Medicinal Delta-9 tetrahydrocannabinol (?9-THC) and potentially other cannabinoids (medicinal cannabis substances) associated with decarboxylated cannabis, including yet not necessarily limited to cannbidiols, and cannabigerol are rendered into a fatty foodstuff and then molded into a mold that also acts as a package. The best mode of the invention is a blister pack containing a plurality of voids or receptacles of desired sizes. A product that is characterized by a controlled amount of medicinal cannabis per unit volume of a fatty foodstuff base material is inserted into the mold, then cooled, and finally sealed. Each void or receptacle contains a known amount of medicinal cannabis that are independently dispensable.

Abstract: A system and method for determining an optimal combination drug product for a particular patient includes a processor that receives patient information and determines an optimal combination drug product based on the received information. A system which can provide information regarding predicted events or pathologies based on received patient information and guidance on subsequent steps to ameliorate, treat or intervent. A drug production device includes a plurality of drug containers, each of which are coupled to a drug dispensing channel. A controller controls the dispensing of drug through each channel, and a combination drug product is produced from the dispensed drugs. A combination drug product includes a plurality of discrete units of a first drug, and a plurality of discrete units of a second drug. A transdermal patch includes a plurality of drug compartments, each containing a quantity of drug product, and a controller for controlling the release of drugs from each compartment.

Abstract: A hybrid mounting card is disclosed that includes one or more receptacles form fit for respective portions of a medical device in order to receive and secure the respective portions of the medical device therein and a mounting card adapted to receive and secure the one or more receptacles. The one or more receptacles are configured on the mounting card to secure the medical device to the mounting card in a defined configuration. The use of the receptacles increases the types of medical devices that can be secured to mounting cards. The use of mounting cards enables medical devices to be stored in sterile barrier packaging systems that do not require custom thermoforming of an entire medical tray, such as medical pouches and standard blank medical trays.

Abstract: An apparatus and techniques for determining whether a medical electrode, such as a defibrillation electrode coupled to an automated external defibrillator, is in a condition for replacement. The determination can be made as a function of one or more data. In one exemplary embodiment, the determination is a function of one or more measurements of an impedance of a hydrogel bridge in a test module. In another exemplary embodiment, the determination is a function of one or more environmental condition data from one or more environmental sensors.

Abstract: A welding boat for a pouch has a center part and two prolongations extending therefrom in opposite directions and tapering acutely. The welding boat has an opening for the filling of the pouch with a substance in manufacture and inlets and outlets for the actual use of the pouch. The center part is substantially filled by an opening with a lumen which is as large as possible and preferably circular, and the side edges of the side prolongations contact the opening tangentially.

Abstract: A disposable surgical kit for fixing the vertebrae using a posterior or postero-lateral route has at least one pedicle screw or vertebral screw and an assembly tube cooperating with the screw. The assembly tube is composed of two independent rigid half-shells. Each of the half-shells has, on the inner face of its proximal end, a shoulder with a shape complementing a recess formed on each side of the screw head in order to permit the gripping or the release of the screw by spreading apart the distal ends of the half-shells The kit additionally has a retractable securing element for securing the half-shells. The retractable securing element has longitudinal fastening means designed as a dovetail for engaging with complementary slides formed in the rigid half-shells.

Abstract: The double packing materials according to the present invention which primarily packs the infusion solution with a polypropylene packing material and secondarily vacuum packs and hermetically seals the packed polyethylene packing material with a material including an aluminum foil ensures safety of the content therein from light and has high thermal resistance and excellent preservation properties that resists to the damage and tearing by external force on long-term storage despite that it is not stored in dark place, and thus is very useful as the packing material for storing expensive infusion solution such as the contrast medium which is radiological diagnostic solution.

Abstract: The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered polysaccharide and a biocompatible liquid comprising one or more block copolymers of ethylene oxide and propylene oxide.

Abstract: A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container is heat sterilisable, and which is in the form of an infusion solution preconcentrate for administration of the bisphosphonate to a patient in need of bisphosphonate treatment.

Abstract: Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament identified for treating a disease selected from the group consisting of diabetes, obesity, hyperglycemia, retinal damage, renal failure, nerve damage, microvascular damage and varicella-zoster virus (VZV) infection is disclosed.

Abstract: Improved methods for the surgical repair of a damaged or severed nerve are described. The improvement includes covering the surgically repaired nerve or a damaged neurilemma with at least one of an amniotic fluid and a construct, or replacing the damaged neurilemma with the construct prior to wound closing during the surgery. The construct contains an allograft having at least one layer of amnion and chorion tissues, and a shape adapted for enclosing a damaged or severed nerve or for covering or replacing the damaged neurilemma during the surgical repair. The products and methods improve the performance of the nerve surgery, e.g., by reducing inflammation, inhibiting fibrosis, scarring, fibroblast proliferation, post-operative infection while also promoting more rapid healing of damaged or traumatized nerve structures.

Abstract: A dual-chamber packaging for medical marijuana-infused products and edibles providing individuals who are suffering from various health problems and diseases with an effective method for ingesting and/or topically applying medical marijuana. The invention may comprise a dual-compartmental containment device made from high-density polyethylene. The two chambers may be separate but are encased in one outer container. Professionally manufactured goods, such as lotions or oils with THC and CBD enhancers and carriers and other beneficial properties, can be kept in the first compartment, while cannabinoid fluid may be contained in the second compartment. For use in transdermal delivery of cannabinoids, an individual may first dispense the professionally-developed material and rub it onto his/her skin. Dispensaries may customize the materials used in this device to satisfy the needs dictated by their patients' specific conditions or diseases.

Abstract: An oral fluid delivery device is provided with a body having a base and a nipple extending from the base. At least one channel projects through the nipple. A fluid reservoir has a proximal end that is secured to the base to form an integrated unit, and a distal end with a vent hole formed therethrough for equalizing pressure within the fluid reservoir. A valve is disposed between the fluid reservoir and the channel for restricting fluid flow through the channel. A piston may be disposed within the fluid reservoir and adapted for translating relative to the base corresponding to the amount of fluid contained within the fluid reservoir.

Abstract: The present invention relates to a pattern coated pressure sensitive label assembly for use in preserving patient privacy in medical treatment bag applications. The label assembly utilizes specific zones and areas to create removable sections that will permit areas containing patient information to be separated from the remainder of the label which remains with the treatment bag during disposal.

Abstract: The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.

Abstract: A vacuum packaging system for transporting a plurality of medical containers includes a plurality of medical containers each having a head side and a base side and a tray that receives and supports the medical containers. The tray includes opposing first and second sidewalls, opposing front and rear walls and a bottom floor. The walls extend generally vertically from the floor of the tray. At least one platform generally extends parallel to the floor of the tray. An air impervious flexible film defines an internal cavity. The air impervious flexible film completely surrounds the tray and the medical containers and the internal cavity is evacuated to and maintained at a predetermined vacuum level below atmospheric pressure. One of the head side and the base side of each medical container contacts a top surface of at least one platform when the medical containers are positioned in the tray.

Abstract: A storage and support device for storing and supporting components of a Functional Electrical Stimulator Foot Drop Device is disclosed and includes an upstanding hollow tubular member extending upwardly from a base portion. The interior of the tubular member may be used to store certain of the components of the foot drop device, other than the leg cuff portion thereof, during periods of non-use. The leg cuff portion of the foot drop device is wrapped around the tubular member with the tubular member having an exterior curved surface which corresponds to the shape to the disc-shaped electrodes at the inner surface of the leg cuff so that a plastic sheet covering the electrodes will be maintained in intimate contact with the electrodes to extend the life thereof.

Abstract: A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.

Abstract: The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human nerve growth factor (hNGF). The formulations may contain, in addition to an anti-hNGF antibody, at least one non-ionic surfactant, at least one sugar, and acetate. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.

Abstract: The invention relates to modified single domain antigen binding molecules, e.g., SDAB molecules, in particular TNF?-binding SDAB molecules. Method of preparing, and using the modified single domain antigen binding molecules described herein, to treat, e.g., TNF?-associated disorders, are also disclosed.

Abstract: The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution. To be specific, the present invention is a patch package structure including a patch 1 and a packaging member 51 holding the patch, wherein the patch 1 includes a support 2 and an adhesive layer 3 formed on at least one surface of the support 2, the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.

Abstract: A container which is not bulky at the time of shipping and can be stably stood on a suitable place. The container includes a lid member for closing a take-out opening (brittle portion) of the container body 2. On the lower outer side of the container body, there are formed slits for fitting the lid member to the container body after the container body and the lid member are separated apart, and auxiliary leg portions that protrude outward of the container body. The lid member is forming holding leg portions that protrude outward therefrom. Wing portions of the holding leg portions are inserted in the slits to fit the lid member to the container body, and the erected attitude of the container body is supported by the holding leg portions.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.

Abstract: The present invention relates to transdermal pharmaceutical compositions such as gels containing a SERM selected from the group consisting of endoxifen, droloxifene, clomifene, raloxifene, tamoxifen, 4-OH tamoxifen, toremifene, danazol and the pharmaceutically acceptable salts thereof, and to methods of making and using the same.

Abstract: A method of orally administering measured doses of sugar into the bloodstream for controlling glucose levels, particularly for those individuals with diabetes or those who experience difficulty maintaining healthy blood sugar levels. The method comprises providing packets of orally ingestible strips of a disintegrating matrix containing a dose of sugar to supplement food intake between meals or to rapidly increase glucose levels in an emergency situation. Hypoglycemia is a condition of low blood sugar (glucose) levels in the bloodstream, which can have varying reactions on individuals ranging from mild to severe. The disclosed matrix and method rapidly introduces sugar into the blood stream for combating a hypoglycemic reaction. The strips are easily deployable and quickly dissolve once placed on the tongue and mixed with saliva. They can be packaged in a small, easy-to-dispense, and transportable case that allows rapid use when a sugar supplement is required.

Abstract: Childproof, highly inert individual dose packagings (1) for transdermal therapeutic systems or film-like forms of administration in the form of a sealing edge bag that can be peeled back with a complete surrounding and continuous sealing surface, comprising two packaging elements, that are arranged on top of each other and form the upper side and the bottom side of a bag containing the product, wherein at least one layer of the packaging material elements is a metal layer and at least one packaging material element a film laminate with at least three-layer design; and the outer layer of the at least three-layer film laminate has a minimum tear resistance of 30 N, wherein said outer layer comprises at least one line-shaped weakening that is not touching the edge of the packaging on the upper and bottom side and the line-shaped weakening has a reduced resistance to tear for opening the packaging. The invention further relates to a method of production thereof.

Abstract: A modular pillbox that includes a base unit and a plurality of modules that can be interchangeably coupled to the base unit. The base unit includes a plurality of interior compartments defined by a top, a bottom and at least one side wall, openable doors that close the tops of the plurality of interior compartments, one-way passages in one of the bottoms or the at least one side wall of each interior compartment through which pills can be pushed into the interior compartments, and an opening in a front portion of the base unit. The plurality of modules includes a cover plate that couples to the base unit and covers the opening, and various electronic packages that removable couple to the base unit and cover the opening.

Abstract: A disposable applicator assembly includes a handle of a diameter substantially larger than the diameter of an applicator stick. The applicator assembly includes a casing, the applicator stick, and an applicator (e.g., a swab). A support structure is disposed within the casing and engages the applicator stick. A product may be housed in the casing for delivery by the applicator. The applicator assembly may be formed of a single material that is suitable for an injection molding process.

Abstract: A disposable absorbent article is provided. The article comprises one or more disposable absorbent articles having a configuration corresponding to a wearer's stage of development, the disposable absorbent articles being enclosed in a package; a brand indicator disposed on the package; a line-up indicator disposed on the package, the line-up indicator including visual indicia and narrative indicia; and a stage specific indicator disposed on the package. The line-up indicator and stage specific indicator associate the absorbent article configuration with a corresponding stage of development, the association enabling a consumer to identify the appropriate absorbent article configuration for a wearer. An array of disposable absorbent article configurations is also provided.

Abstract: The invention concerns a peel-off package for sterilization.

Abstract: For a dispenser (1) comprising the components of a reservoir (5) having a plurality of compartments (6), and a positioning disc (16) having a plurality of exit orifices (15), a solution shall be provided which allows realizing such a dispenser in a smaller sized configuration and which allows to dispense capsules or pills stored therein in a unit dose manner. This is achieved by additionally providing the component of a guiding member (56, 56a) being rotatably arranged in between the reservoir (5) and the positioning disc (16) and respectively connecting one compartment (6) with one dedicated exit orifice (15) in dispensing communication by accomplishing a rotary/rotational step.

Abstract: A catheter lock solution which is a catheter lock preparation having a bacteriostatic property at physiological osmotic pressure without practically containing a bacteriostatic component such as a preservative, an antimicrobial agent, or an antibiotic and having high safety, characterized in that the preparation contains a weak acid having an acid dissociation constant (pKa) of 3.0 to 6.5 as a buffer, a pH of the solution is less than 6.0, preferably from 3.0 to about 5.5, an osmotic pressure ratio is from 0.5 to 3.0, and a pH change (variation) can be suppressed to less than the 6.0 with the weak acid, and a container containing the catheter lock solution.

Abstract: A collapsible box for disposal of articles such as sanitary wear, comprises a base, at least three walls upstanding therefrom and a top, the top having an aperture through which articles or items may be placed in the box and a flap at least partially occluding the aperture, the flap being urged upwardly and at least a part of which being engaged by a wing portion to inhibit upward motion thereof, the wing portion being moveable between a first condition for collapsing the box and a second condition at least partially overlying the aperture.

Abstract: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

Abstract: The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of alkylating or alkylating-like agents, antimetabolite agents and topoisomerase I inhibitors, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.

Abstract: A package for a flat medical implant includes a flexible outer component, such as Tyvek®, including a first panel and a second panel foldable over said first panel for closing the package, and an inner component, such as paper, mechanically interlocked with the flexible outer component. A flat medical implant is held by the inner component. While the outer and inner components remains mechanically interconnected to one another, the upper ends of the first and second panels of the outer component are peelable away from one another for opening the package and accessing the flat medical implant at an upper end of the package.

Abstract: In order to improve a surgical screw container comprising a receiving part and a closure part mounted thereon so as to be movable, wherein the receiving part has at least two screw receptacles for accommodating at least two bone screws, wherein the closure part can be brought relative to the receiving part into at least one closure position, in which none of the screw receptacles is accessible for the introduction or removal of a bone screw, such that any loss of screws from the screw container can be practically ruled out it is suggested that the closure part can be brought from the at least one closure position into at least two removal positions, in each of which only a single screw receptacle is accessible for the introduction or removal of a single bone screw.

Abstract: An anastomosis surgical device comprising an elongate body having a drainage aperture at a distal end for communication with a proximal end of the elongate body, tissue approximating structure extendable from the elongate body and spaced proximally from the drainage aperture along the length of the elongate body. The device further includes an actuating mechanism extending from the proximal end of the elongate body and comprising at least one tissue approximating structure control mechanism, and a protective enclosure surrounding at least a portion of the actuating mechanism.

Abstract: A medical device holder is comprised of a flexible elongated sheet member, and includes a holding portion configured to hold a three-dimensionally configured part connected of the device. The holding portion is configured to bend back on itself to cover the three-dimensionally configured part. A slit is provided in the sheet member to allow insertion of the distal end portion of the holding portion so that the state in which the holding portion covers the three-dimensionally configured part connected can be maintained. The distal end portion of the holding portion is folded toward the opposite direction from the direction to pull out when retrieving the catheter from the sheet member.

Abstract: A sanitary hypo-allergenic latex-free disposable anti-fomitic device is provided. The anti-fomitic device comprises a sheet of a microorganism-impenetrable material comprising a first side and a second side, and a pressure-sensitive adhesive, such as, for example, a covering used in medical tape, covering at least a portion of the first side.

Abstract: Provided is a package of a solid pharmaceutical preparation capable of preventing an unpleasant odor and coloring due to hydrolysis progressing during storage of a solid pharmaceutical preparation containing 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid. A package of a solid pharmaceutical preparation housing a solid pharmaceutical preparation containing 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid includes a PTP package, an adsorbent, and an outer packaging material. The PTP package includes the solid pharmaceutical preparation, a container sheet for housing the solid pharmaceutical preparation, and a cover sheet having gas permeability sealing the solid pharmaceutical preparation. The adsorbent includes at least zeolite. The outer packaging material includes a gastight material to house and seal the adsorbent and the PTP package.

Abstract: The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

Abstract: An ear cap supplying device, an ear cap and an ear cap set are provided. The ear cap supplying device includes a containing device, a first structural member, a second structural member, and a third structural member. The containing device is used for containing a first ear cap and a second ear cap. The second ear cap is stacked above the first ear cap. The first structural member movably supports a lower part of the first ear cap. The second structural member movably touches an upper part of the first ear cap. The third structural member movably supports a lower part of the second ear cap. Whereby, the successful output probability of the ear cap(s) can be increased.

Abstract: A storage unit for storing and/or making available at least one carrier for at least one surgical item, in particular for at least one bone screw. The carrier can be brought to a holding position and to a release position, the carrier being held by the storage unit in the holding position and being released or releasable from the storage unit in the release position. The storage unit has at least one release part. The carrier can be brought from the holding position to the release position by actuation of the release part. The invention further relates to a set containing at least one such storage unit and at least one carrier for at least one surgical item, in particular for at least one bone screw. The invention moreover relates to a surgical container containing at least one storage unit and/or at least one set.

Abstract: The present invention relates to methods for the treatment of skin wounds or lesions, and connective tissue damage or injury, comprising administering to a subject an effective amount of a glucan composition. Also provided are methods for the promotion of wound healing and tissue regeneration.

Abstract: The present disclosure provides a package for a medical device containing a cavity for receiving the medical device, a first closure having a sealed portal therein and a second closure adjacent the first closure.

Abstract: Therapeutic compositions, devices and protocols for the treatment of keloids and other abnormal scars with improved appearance and a much lower recurrence rate. A therapeutic drug delivery device comprises an injectable mixture of a fibroblast inhibitor such as corticosteroid and a slow release carrier such as milled gel sponge dispersed in a fluid medium such as biological saline. The composition can be injected perilesionally in the dermis following excision of the keloid or other scar tissue, to circumscribe the wound. The infiltration of the mixture around the wound can provide a slow release of the fibroblast inhibitor for an extended period of time until normal wound closure can dominate and keloid or abnormal scar recurrence is inhibited.