Abstract: The present invention provides a kit, a method of fabrication of the kit and a method of use of the kit for facilitating the fabrication of a patient-specific implant such as a cranial implant. In a preferred embodiment, the kit 30 includes a thermo-formed plastic sheet 32, a portion 34 of which is formed of PP plastics to the three dimensional contour of a bone structure of a specific patient. The thermo-formed sheet 32 optionally doubles as a container 36 for the remaining elements of the kit, which include bone cement 40a, 40b (typically in two part form, each part contained in a separate container device), and, optionally, disposable forming and/or mixing aids 42 such as a spatula. A kneading recess 44 is also formed in the thermoformed sheet 32 of the kit 30. A sheet 46 is adhered via adhesive 48 and extends between flanges 50 of the thermo-formed sheet, to seal and keep sterilized the components 40a, 40b and 42 and the mould recess (shaping form) 34 of the kit 30 within the container 36.

Abstract: A medical device package includes an elongate tubular holder having a first and a second detachable tip, and a medical device positioned within a cavity and contained within the holder via the first and second detachable tips. The medical device has a self-shaping bias and is loaded in opposition to the bias via contact with an inner surface of the holder defining the cavity. The first and second detachable tips may include snap-off tips, such that upon detachment the cavity is opened for removing the medical device. Related methodology is disclosed.

Abstract: Methods and apparatus for grasping an object using a re-closable bag with integrated finger sleeves. The re-closable bag includes a flexible side panel, an opening on a top end of the bag, and at least two flexible finger sleeves connected to the side panel. The opening includes a closure adapted, when closed, to seal the bag. The at least two flexible finger sleeves, when in a first position, are disposed between a first portion and a second portion of the side panel. Each finger sleeve in the two or more finger sleeves is adapted to accept at least a portion of a human finger. In some aspects, an object grasped using the finger sleeves can be retracted into the re-closable bag with integrated finger sleeves and stored within the bag.

Abstract: Disclosed are cartridge filling systems and methods that can include providing a vial body defining a vial lumen, providing a floating stopper positioned within the vial lumen, providing an end cap, where the proximal end of the end cap can abut the distal end of the floating stopper such that the floating stopper is prevented from moving distally within the vial lumen, filling at least a portion of the vial lumen with a fluid, and removing the end cap from the vial body after filling at least a portion of the vial lumen with a fluid.

Abstract: A carrying case (500) and handle (504) for accommodating a portable topical negative pressure therapy apparatus (200) comprising a device (202) and a waste canister (204) separable therefrom, the waste canister having an aspiration conduit (274) emerging therefrom is described, the carrying bag comprising an apparatus receiving pouch (502), said pouch having opening and closing means (522, 524) at a lower portion thereof and said handle (504) being directly attached to said apparatus.

Abstract: A carrying case, which accommodates a pharmaceutical injection device for administering a pharmaceutical to a living body, comprises a case unit configured to accommodate the pharmaceutical injection device therein and a temperature regulation unit configured to regulate a temperature within the case unit. The temperature regulation unit includes: a cooling execution section configured to execute a cooling operation; a cooling fan configured to supply a cool air into the case unit; and a cooling control section configured to control the cooling execution section.

Abstract: A medical device includes a casing, a cover member that covers a portion on one-direction side of the same, and a sheet member interposed therebetween. The cover member includes on its periphery a hook part having a hook-like portion and a protrusion. The casing includes a latch part configured to engage with the hook part and a fitted portion for the protrusion to fit in. The sheet member includes an alignment part for aligning itself with the cover member. The cover member preferably has optical transparency. The casing preferably includes a recess shaped to fit with an outer shape of the cover member at a portion to be covered by the cover member.

Abstract: A merchandise system for disposable absorbent articles is provided. The merchandise display system includes a first line-up and second line-up of disposable absorbent articles designed to match a wearer's stage of development. The system also includes various color schemes associated with the first and second line-ups in order to facilitate consumers' identification and selection of the appropriate absorbent article configuration for a particular wearer. A merchandise system for baby care articles is also provided.

Abstract: A container for housing an injectable fluid vial. The container includes a calculation aid formed specific to the injectable fluid vial. The container is formed from a bottom, a top, and an inset side wall therebetween with a resealable lid. The top includes an opening constructed and arranged to receive the fluid vial housing. Alternatively, the container is formed from two half sections that are hinged together for holding the fluid vial housing therebetween. An inner label is permanently attached to the sidewall having at least one row of dosing indicia coordinated with a base line indicia selected from the group of weight, age, fluid volume or area. An outer label is rotatably secured over said inner label with at least one transparent window allowing selective viewing of the dosing and base line indicia and predetermined dosing rate.

Abstract: A packaging for a medical glove includes a cover defining an interior space, a sealed end and an opposing end having an opening in communication with the interior space, at least one deployable member with a distal end extending from the cover opening into the interior space, and a proximal end being part of the cover opening, the deployable member segregating the interior space into an inner clean and contaminant free area adjacent to the sealed cover end and an outer area adjacent to the cover opening, the distal end of the deployable member being movable from a first position within the interior space to a second position outside the cover opening, and means for securely retaining the medical glove on the distal end of the at least one deployable member.

Abstract: Disclosed herein are compositions and methods to treat skin with a peracid-based benefit agent. The peracid benefit agent can be used for a benefit such as the prevention or treatment of acne, skin whitening, skin bleaching, skin conditioning, reducing the appearance of skin wrinkles, skin rejuvenation, reducing dermal adhesions, and preventing, reducing or eliminating body odors or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a skin-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the skin surface.

Abstract: The present invention relates to a container for storing veterinary preparations and administering veterinary preparations contained therein to a target animal species, especially for the oral delivery of active therapeutic agents to free-roaming animals. Described is also a bait for animals comprising at least one container surrounded by an encasement or a carrier, made from material having a texture that is at least soft or bendable or elastic or resilient at ambient temperature and wherein the container surrounded by the carrier is also made from material having a texture that is at least soft or bendable or elastic or resilient at ambient temperature. The bait contains in the carrier and/or on the surface of the container at least one additive enhancing the cohesion of carrier and container.

Abstract: Surgical wrappers and related methods are provided. A reusable surgical wrapper can include a first layer that includes a fabric having at least one of synthetic fibers or synthetic yarns. In some embodiments, a surgical wrapper can include a first layer comprising a first fabric that repels fluids forming a first face of the surgical wrapper. A second layer can be provided that includes a second fabric forming a second face of the surgical wrapper. A seam binding can be disposed around at least a portion of an outer edge of the first fabric and an outer edge of the second fabric to join the first layer and the second layer to form a dual layered surgical wrapper.

Abstract: Containers with pH indicators are disclosed. The pH indicator is in contact with the contents of a container and detects changes in the pH of the contents.

Abstract: A plastic container containing a pharmaceutical composition comprising benzoic acid or a derivative or a pharmaceutically acceptable salt thereof and a COX-inhibitor of the oxicam-type or a pharmaceutical acceptable salt thereof, wherein the container material selected from one or more members of the group consisting of a homopolymer of polypropylene (PP), a copolymer of polypropylene (PP), a homopolymer of polyethylene terephthalate (PET) and a copolymer of polyethylene terephthalate (PET), and optionally one or more non-polymeric components.

Abstract: Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Abstract: A catheter assembly includes a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package includes a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, which defines a flap opening; a third sheet material connected by means of an adhesive over said flap opening. The third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. The third sheet material forms a tab not provided with adhesive and the tab provides a grip portion for peel opening of the package.

Abstract: A method of closing the distal end of an ampoule is shown. The ampoule has a variable diameter head portion having a locating surface and an opening. A septum is positioned on the opening and secured to the head portion with a ferrule using a plunger. The plunger exerts a force in a proximal direction to press the ferrule on the head portion until the press causes the ferrule to contact the locating surface. Further, the ampoule for use in a cartridge for a drug delivery device has non-standard dimensions to provide a coding system to reduce the risk of a user dispensing the wrong medicament from the drug delivery device.

Abstract: An implantable medical device is stored in a container prior to implantation in body tissue. The IMD includes transmitter/receiver circuitry and at least one antenna. The storage container (packaging) includes an impedance altering substance positioned in proximity to the IMD when stored in the container, the substance having electrical material properties that alter the input impedance of the antenna to improve the reception and transmission properties of the antenna when the IMD is stored in the container. A container for storing an IMD having an antenna has a packaging tray for housing the IMD, the packaging tray having a support for supporting the IMD and the container including a substance positioned in proximity to the support that has electrical material properties that after the input impedance of the antenna of the IMD supported by the support, so as to improve the reception and transmission properties of the antenna.

Abstract: A piston nest (10) is provided that includes a plurality of spaced apart single nesting units (12) interconnected by a web (13). Each of the single nesting units is configured a hollow cylindrical body having a first open end about a distal end of the body and a second open end about the proximal end. The hollow cylindrical body also includes a first (24) and a second (26) retention member for retaining a piston within the single nesting unit. The first and the second retention members are spaced apart along a longitudinal axis of the hollow cylindrical body.

Abstract: A case is described for use, for example and without limitation, with a nipple shield or nipple protector. The case, which has an interior volume to contain a nipple shield/protector, generally provides a rigid container to protect a nipple shield/protector and to protect it from the environment. Certain embodiments provide rigid container that may be opened to place or remove a nipple shield/protector and closed to hold the shield/protector with a minimal amount of contact. The case may also include ventilation holes to permit drying of the contents of the case.

Abstract: A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.

Abstract: The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.

Abstract: A system comprising a nebulizer, in particular inhaler, having a pre-installed container is proposed. The system comprises a packaging preventing fluidic connection or opening of the container in a delivery state of the nebulizer.

Abstract: A pharmaceutical composition and method for the treatment of asthma or other respiratory disease by inhalation from a pressurized metered dose inhaler (pMDI), a dry powder inhaler (DPI) or nebulizer, the composition and method being based on a combination of a short acting beta agonist (SABA) and an inhaled corticosteroid (ICS) in a form adapted to be delivered for inhalation from the pMDI, DPI or nebulizer.

Abstract: A method is provided for storing a medical device. One step of the method includes providing a medical device having an initial tensile strength. The medical device is placed into a storage container so that at least a portion of the medical device is immersed in a hydrophobic liquid. Next, the medical device is stored in the storage container for a period of time. The initial tensile strength of the medical device is substantially preserved over the period of time.

Abstract: The present invention relates to a trolley (10) for a medical waste container (12) for use in a medical treatment facility such as an operating theatre or other hospital or medical environment. The invention also relates to a cart (100) for transporting a collection of the medical waste containers (12) throughout the medical treatment facility.

Abstract: The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.

Abstract: For the secure keeping of wafers 8 and for prevention of penetration and/or migration by an active ingredient present in the wafer 8 into the packaging material of a primary pack which serves to keep the wafer 8, and, furthermore, for the easy removal of the wafer 8 after the opening of the primary pack, a wafer sachet 1 as the primary pack is proposed, being formed by a layer construction of films, which comprises first and second sealing films 3, 4 which are connected to one another via at least one sealing region, so that between the first and second sealing films 3, 4 a cavity 7 is formed which is closed off to the outside and is suitable for receiving the wafer 8.

Abstract: In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.

Abstract: A package for individually packaged good of absorbent article includes an individually packaged good having a main body portion and a pair of extended portions; a bag body housing individually packaged goods; and a box body that houses the bag body housing the individually packaged goods, in which the individually packaged goods are housed in the bag body such that a position of the extended portions is aligned; the bag body is housed in the box body such that a pair of side faces, to which the pair of extended portions is directed, is positioned to face a pair of opposite internal faces of the box body; and a length L1 between ends of the pair of extended portions of the individually packaged good, in a state in which the extended portions are straightened, is greater than a length L2 between the pair of internal faces of the box body.

Abstract: A high silica glass composition comprising about 92 to about 99.9999 wt. % SiO2 and from about 0.0001 to about 8 wt. % of at least one dopant selected from Al2O3, CeO2, TiO2, La2O3, Y2O3, Nd2O3, other rare earth oxides, and mixtures of two or more thereof. The glass composition has a working point temperature ranging from 600 to 2,000° C. These compositions exhibit stability similar to pure fused quartz, but have a moderate working temperature to enable cost effective fabrication of pharmaceutical packages. The glass is particularly useful as a packaging material for pharmaceutical applications, such as, for example pre-filled syringes, ampoules and vials.

Abstract: An exemplary embodiment of a probe cover dispenser includes a storage member for accommodating stacked probe covers and a retaining unit with a pair of supporting arms for holding or releasing one of the stacked probe covers. A slide connects the retaining unit. A linking rod with a protrusion portion and a recess portion connects the slidable access member. The linking rod is moved upwardly or downwardly and the protrusion portion or the recess portion is moved to a position corresponding to the slide such that a force is applied to push or pull the supporting arms to release or hold the one of the stacked probe covers in the storage member, while the slidable access member is moved upwardly or downwardly.

Abstract: A carrying case (500) and handle (504) for accommodating a portable topical negative pressure therapy apparatus (200) comprising a device (202) and a waste canister (204) separable therefrom, the waste canister having an aspiration conduit (274) emerging therefrom is described, the carrying bag comprising an apparatus receiving pouch (502), said pouch having opening and closing means (522, 524) at a lower portion thereof and said handle (504) being directly attached to said apparatus.

Abstract: A package for a medical device having a handle and an elongated shaft. The package includes a holster for holding the medical device, the holster having a tubular member for receiving the elongated shaft and a handle cover located at a proximal end thereof. The handle cover has a holster opening for accessing the handle to draw the medical device from the holster. The package includes a pouch having a sealed area bounded by a top sealed edge, a bottom sealed edge, a pair of side sealed edges extending between the top and bottom sealed edges, and at least one opening tab spaced from the bottom sealed edge. The medical device and the holster are disposed within the sealed area of the pouch with the elongated shaft of the medical device extending along the bottom sealed edge and the holster opening being located adjacent the at least one opening tab.

Abstract: An ophthalmic solution is provided. The ophthalmic solution is hypertonic. The ophthalmic solution includes a polysaccharide having an average molecular weight of between about 40,000 grams per mole and about 150,000 grams per mole. A packaged ophthalmic solution for preventing the ophthalmic solution from being exposed to CO2 and other contaminants is also provided. The ophthalmic solution can be used to treat recurrent corneal erosion. The ophthalmic solution can also be used as a prophylactic to prevent recurrent corneal erosion.

Abstract: A cup assembly for holding a sample to be analyzed spectrochemically, includes a tubular longitudinal member which is disposed symmetrical about a central axis. The tubular member extends longitudinally between a first end and a second end. An indented peripheral flange is defined at the second end. The indented flange has an inverted L shaped cross-section. An annular collar extends longitudinally between a first end and a second end. An internal peripheral flange is defined at the first end. The internal flange has an inverted L shaped cross-section complementing the indented flange of the tubular member. When a substantially thin film is interposed between the second end of the tubular member and the first end of the annular collar, the film is retained between the sample cell body and the collar between the indented flange and the internal flange. The cup may have a funnel shaped sample retaining chamber.

Abstract: The present invention provides a notebook cooling pad, fan seat, docking station, and/or card reading station combination device. The combination device enables a notebook cooling pad to be coupled with a cooling fan, a port, and/or a card reader. The combination device is characterized in that paired symmetric cooling pads can be combined with or separated from a fan seat, a docking station, and/or a card reading station for operational purpose, such that the compact combination device is characterized by multiple purposes, multiple functions, and multiple ways of use.

Abstract: An article (20) has a longitudinal length (22), an article width (24) and an article thickness (26). The article (20) comprises a fresh personal care product (28) in a substantially unsoiled condition, and a pouch (30) having a pouch volume which operatively encloses the fresh product (28). The pouch (30) includes a front panel region (32), a back panel region (34) which is operatively connected to the front panel region (32), and at least one expansion section (48) which is operatively connected between the front panel region (32) and the back panel region (34). The expansion section (48) is operatively held in a substantially unexpanded, closed position when the fresh product (28) is enclosed in the pouch (30). The expansion section 48 is movable to an open position after a removal of the fresh product (28) from the pouch (30).

Abstract: The invention provides a packaging for a medical article e.g. for a urinary catheter. The medical article is stored in a compartment and can be accessed by detaching a first element from a second element thereby forming an opening into the compartment. The first element comprises a suction cup or another fastening element by which the packaging is attachable to a surface. Due to the structure of the packaging, it can be supported in an orientation in which the opening is remote from the surface, and risk of contamination of the medical article can therefore be reduced during removal of the article from the packaging.

Abstract: The invention relates to biocompatible bone graft materials for repairing bone defects and the application of such bone graft materials.

Abstract: An individually packaged absorbent article assembly including a tri-folded absorbent article having two end portions and an intermediate portion, and a pouch containing the tri-folded absorbent article, the pouch be structured and arranged to enable a user to selectively open the pouch to thereby expose a garment-facing surface of the intermediate portion of the absorbent article prior to exposing a garment facing surface of either of the end portions of the absorbent article.

Abstract: A device for treatment of nosebleeds having an elongated body configured to be positioned between the upper gum and the portion of the face below the nose and above the top lip of a human. When so positioned intra-orally, the device exerts pressure on an area of nasal vascularization of the human. Also, a nosebleed package having a sterile inside environment and a nosebleed device packaged therein, and a box containing a plurality of nosebleed packages.

Abstract: An individual package of sanitary tampon that can be easily opened and can avoid any unintended seal breakage while being carried. The individual package of tampon comprises a vertically long, flat bag body made of a sheet-shaped member and a tampon with applicator individually enclosed in the bag body. The individual package further comprises a seal breaking part with one or more cut portions provided continuously or intermittently along a given direction of the sheet-shaped member and a buffer structure part provided on one side or both sides of the seal breaking part in the seal breaking direction. The buffer structure part has a slack portion formed by slacking the sheet-shaped member.

Abstract: A lip enhancement and enlargement device includes a suction element and a lip shaper coupled to the suction element. Each type of lip shaper includes one or more features that allow the device to shape and contour lips. A lip shaper may include one or more contouring elements that change the shape of an upper lip, for example. A lip shaper may also include shaping and contouring elements that form a fuller, unitary lip lobe or two fuller, lip lobes. Lip enhancement and enlargement kits and methods are also disclosed.

Abstract: A grommet device and method of using a grommet device is provided. The grommet device includes a base structure and a top structure connected to the base structure with a plurality of sidewalls, wherein an aperture having a central axis is formed interior of the plurality of sidewalk. At least one flexible bowed element having a first end, a second end and a middle portion is connected to the base structure at the first end and the top structure at the second end, wherein the middle portion is positioned within the aperture.

Abstract: An injectable pharmaceutical composition contained in a receptacle for injection into a human, which comprises a solution of zoledronic acid or the salts thereof, a solvent and a pH regulator.

Abstract: The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

Abstract: A biopsy marker delivery device are described. The delivery device can include a relatively flexible hollow tube, a pushing member such as a push rod disposed for sliding with the tube, and at least one marker disposed in the tube. A marker blocking member is disposed distal of the distal most marker, and is disposed at least partially within the hollow tube to assist in preventing premature deployment of a marker from the hollow tube. A portion of the blocking member may disposed in the hollow tube, and another portion of the member may be operatively associated with a portion of the package such that when the marker delivery device is removed from the package, the member is removed from the marker delivery device.

Abstract: A device for supporting at least one vessel containing a target material to be lyophilized generally includes a support panel, a central region, a perimeter region, a thermal shield, and at least one shielding cavity. The support panel has a support surface. The central region is defined by the support panel for supporting the at least one vessel. The perimeter region is also defined by the support panel and surrounding the central region. The thermal shield is positioned about the perimeter region and extends transverse to the support surface of the support panel such that the thermal shield and the support panel define a storage space for accommodating the at least one vessel. The at least one shielding cavity is defined by the thermal shield and contains a shielding material during a lyophilization process. The shielding material is distinct from the target material.