Diffusing Or Passing Through Septum Selective As To Material Of A Component In Liquid/liquid Solvent Or Colloidal Extraction Patents (Class 210/644)
  • Patent number: 7285209
    Abstract: The invention discloses an apparatus for filtration of water from hydrocarbons comprised of a fresh-feed inlet, a first dead end filter, that is hydrophobic, a second sweeping-flow filter, that is hydrophobic, a common housing containing both the first and second filters, a system for the recirculation of the retentate, a chamber for water settling, and an outlet for clean fuel permeate. This invention takes advantage of the properties of the functional groups of a surfactant, by using the surfactant to allow a hydrophobic medium to attract water, attach the water molecules to the hydrophobic medium, and then allow for agglomeration of the water molecules, which finally become large enough to detach and be swept away by the sweeping-flow. This invention can thus be used to remove high concentrations of water, up to 5%, in hydrocarbons, while allowing a high flow rate by preventing blockage of the final filter by water.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: October 23, 2007
    Inventors: Guanghua Yu, Chang-Wei Jen, Montfort Thierry
  • Patent number: 7276163
    Abstract: A crossflow membrane device that receives a feedstock at a feed end face and separates the feedstock into permeate and retentate. The device has a membrane support containing at least one monolith of porous material defining a plurality of passageways extending longitudinally from the feed end face of the monolith to a retentate end face of the monolith through which the feedstock flows to pass retentate from the device. A permselective membrane coating of finer pore size than that of the porous material is applied to the passageway wall surfaces of the monolith. At least one permeate conduit is formed within the monolith, the conduit containing a plurality of longitudinal permeate chambers communicating with a means of permeate introduction at or near the feed end face and permeate withdrawal at or near the retentate end face.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: October 2, 2007
    Assignee: CeraMem Corporation
    Inventors: Robert L. Goldsmith, Bruce A. Bishop
  • Patent number: 7255792
    Abstract: There is provided a process for modifying a first organic composition comprising (i) at least one first solvent, (ii) at least one solute, and (iii) optionally, at least one second solvent to produce a modified organic composition in which the concentration of the at least one first solvent is reduced and the concentration of the at least one second solvent is increased, comprising the steps of: (a) providing a selectively permeable membrane having a first surface and a second surface; (b) transferring a portion of the first solvent and optionally a portion of the solute from the first surface to the second surface across the membrane by contacting the first organic composition with the first surface, wherein the pressure at the first surface is greater than the pressure at the second surface, and wherein the membrane is a selectively permeable membrane such that the membrane rejection (R) of the solute is greater than 0%; (c) adding a portion of the second solvent to the organic composition retained at the f
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: August 14, 2007
    Assignee: Membrane Extraction Technology Limited
    Inventor: Andrew Guy Livington
  • Patent number: 7198721
    Abstract: An aeration system for a submerged membrane module has a set of aerators connected to an air blower, valves and a controller adapted to alternately provide a higher rate or air flow and a lower rate of air flow in repeated cycles. In an embodiment, the air blower, valves and controller, simultaneously provide the alternating air flow to two or more sets of aerators such that the total air flow is constant, allowing the blower to be operated at a constant speed. In another embodiment, the repeated cycles are of short duration. Transient flow conditions result in the tank water which helps avoid dead spaces and assists in agitating the membranes.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: April 3, 2007
    Assignee: Zenon Technology Partnership
    Inventors: Pierre Lucien Cote, Arnold Janson, Hamid R. Rabie, Manwinder Singh
  • Patent number: 7166473
    Abstract: The invention relates to an assay method for assessing a transferrin variant or combination of transferrin variants for the diagnosis and monitoring of alcoholism, and to kits for performing the assay. In particular, the invention provides a method of producing an algorithm for determining the content of a transferrin variant or combination of transferrin variants, preferably a CDT variant or combination of CDT variants, in a sample of body fluid, said method comprising: (a) obtaining at least two solutions each having known contents of asialo- (A1, A2, A3, etc.) and disialo-transferrins (D1, D2, D3, etc.); (b) determining the content in each of said solutions of a transferrin variant or combination of transferrin variants fractions substantially free from tri- and higher sialylated transferring; (c) determining the total transferrin variant content (T1, T2, T2, etc.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: January 23, 2007
    Assignee: Axis-Shield ASA
    Inventors: Erling Sundrehagen, Asgeir Husa, Ingar Eilertsen
  • Patent number: 7147616
    Abstract: A method for emptying a blood circuit of an apparatus for the extracorporeal treatment of blood after interrupting a treatment session. The apparatus has a blood treatment device with first and second compartments separated by a semi permeable membrane, an arterial pipe connected to an inlet of the first compartment, a venous pipe connected to an outlet of the first compartment and a second end, and a used liquid circuit having a drain pipe connected to an outlet of the second compartment. The method involves the closing of the blood circuit on itself. The blood circuit includes the arterial pipe, the first compartment of the blood treatment apparatus, and the venous pipe, in order to form a closed loop circuit after the arterial and venous pipes have been disconnected from the vascular system of the patient. The blood circuit contains a liquid, which is transferred from the closed loop circuit into the used liquid circuit.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: December 12, 2006
    Assignee: Gambro Hospal (Schweiz) AG
    Inventors: Renato Pedrazzi, Paolo Rovatti
  • Patent number: 7144735
    Abstract: An electrodialysis method and apparatus are provided for treating a sample including trace metals in a matrix. Advantageously, the present invention allows for highly accurate detection of trace contaminants in a solution sample, in particular trace metals, substantially in real-time and on-line. The present invention includes flowing a carrier solution through a carrier solution channel separated from a sample channel by a membrane. A component of the carrier solution is diffused through the membrane into the sample channel to stabilize trace metals in the solution sample for subsequent analysis. Simultaneously, the matrix is eliminated, neutralized, and/or modified for enhanced analysis.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: December 5, 2006
    Assignee: Metara, Inc.
    Inventor: Harmesh K. Saini
  • Patent number: 7128837
    Abstract: The present invention relates to hollow fiber membrane modules for use as “immersion modules” in filtration and/or dialysis methods, in particular whenever impairments due to fouling effects are expected from the use of liquids that are contaminated or lead to deposits. The hollow fiber membrane module comprises at least one housing and a plurality of tubular hollow fiber membranes which are arranged parallel to one another in and/or around the housing in a packing space, wherein the volumetric ratio of all the hollow fiber membranes arranged in the packing space to the packing space is less than 20%. Methods for producing such hollow fiber membrane modules are also provided.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: October 31, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Behrendt, Reinhard Gergen, Franz-Josef Gerner, Gerhard Herres, Berthold Szperalski, Eckehard Walitza, Wolfram Weber
  • Patent number: 7105089
    Abstract: A liquid-liquid extraction system including an outer chamber and an inner chamber. The outer chamber is adapted to contain one of a feed solution and a liquid extractant and defines a containment region. The inner chamber is adapted to contain the other of the feed solution and the liquid extractant within a lower portion of the inner chamber. The inner chamber is defined by a microporous membrane sleeve that internally maintains a frame. Upon final assembly, at least the lower portion of the inner chamber is positioned within the containment region of the outer chamber such that the microporous membrane sleeve establishes an extraction interface between contents of the inner and outer chambers. In one embodiment, the flow region of the microporous membrane sleeve is immersed within a feed solution otherwise contained within the outer chamber.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: September 12, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Dan L. Fanselow, Todd W. Johnson
  • Patent number: 7074333
    Abstract: A method of recovery of DNA fragments using ultrafiltration. The method of the present invention relates to the separation and/or fractionation of double stranded linear nucleic acids using continuous pressure differential ultrafiltration to achieve improved recovery of small PCR products. In one embodiment, dilution of sample such as small PCR products is carried out prior to purification by ultrafiltration. Subsequent filtration of linear DNA, for example, under diluted conditions significantly increases the recovery of smaller PCR products, and improves the recovery of larger DNA fragments as well. In another embodiment, reduced vacuum pressure is used during ultrafiltration to increase the recovery of smaller PCR products and improve the recovery of larger DNA fragments as well.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: July 11, 2006
    Assignee: Millipore Corporation
    Inventor: Michael S. Colman
  • Patent number: 7063792
    Abstract: A method for separating a metal (a) from a metal (2), preferably zirconium from hafnium, which consists in dissolving said metals in an aqueous solution wherein said metals are in a state preventing them from passing through a nanofiltration membrane; treating the aqueous medium with a ligand, for example EDTA, which is complexed with metal (1) and/or metal (2), then in passing the resulting treated medium on a filtering membrane allowing through the ligand-metal complexes, but retaining the metals not complexed with the ligand.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: June 20, 2006
    Assignee: Compagnie Europeenne du Zirconium CEZUS
    Inventors: Noël Ozanne, Marc Lionel Lemaire, Alain Jean-Louis Guy, Jacques Henri Foos, Stéphane Pellet-Rostaing, Frédéric Chitry
  • Patent number: 7056440
    Abstract: A device for the dialysis of a sample includes a hermetically sealed sample chamber formed by a gasket with dialysis membranes affixed to each side in facing relationship. The gasket is impermeable to the sample being dialyzed, but is penetrable and reusable such that a sample introduction mechanism can be inserted through the gasket into the chamber, and then withdrawn without sample being permitted to leak. The device is fitted into a rigid housing containing windows and at least one port parallel to the dialysis membranes for directing the sample introduction mechanism into the gasket. The housing includes at least one pressure ridge for assisting in hermetically sealing the sample chamber and air chamber at one end for causing the device to float in an upright position when immersed in a dialysate.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: June 6, 2006
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Paul J. Haney, William Klungle
  • Patent number: 6951610
    Abstract: Method and devices for producing aqueous iodine and other halogen solutions for dietary, disinfection, sterilization and preservation purposes and the uses thereof.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: October 4, 2005
    Inventors: John Alex Leonard, Maurice Tinkler
  • Patent number: 6913697
    Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: July 5, 2005
    Assignee: Science & Technology Corporation @ UNM
    Inventors: Gabriel P. Lopez, Steven R. Brueck, Linnea K. Ista
  • Patent number: 6913776
    Abstract: Plant for the separation of undesirable substances from alimentary liquids, in particular from wine, which comprises a unit (3) with hydrophobic membranes (4) having holes (5) for trapping gas (G), supplied with wine to be treated (V) by means of first circulation means (6) and with an extraction fluid (L) having an alcoholic content substantially similar to that of the wine to be treated (V), by means of second circulation means (7). The two fluids pass along the two sides (4?,4?) of the membranes (4), allowing the removal of the undesirable volatile substances which pass through the latter. The extraction fluid (L) is made to circulate by the second means (7) inside a purification circuit (8) which comprises a unit (9) for separation of the volatile substances, consisting preferably of an ion-exchange column.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: July 5, 2005
    Assignee: Enologica Vason S.r.l.
    Inventor: Roberto Ferrarini
  • Patent number: 6905029
    Abstract: A method, system, apparatus, and article of manufacture provide a cross-flow migration classifier capable of separating particles. The classifier provides a channel through which a sample, having one or more particles, passes in a first direction, wherein the channel comprises two or more walls that are permeable to a flow of fluid. A cross-flow enters the channel through one of the permeable walls and exits through another of the permeable walls. An imposed field is applied in a second direction that is counter to the cross-flow and having an orthogonal component to the first direction. The imposed field causes one or more of the particles to migrate at a first velocity opposite and/or equal to a second velocity of the cross-flow. The particles that migrate opposite to the cross-flow are continuously discharged from the cross-flow migration classifier.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 14, 2005
    Assignee: California Institute of Technology
    Inventor: Richard C. Flagan
  • Patent number: 6858146
    Abstract: Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes (23) which are either unattached or attached to inert carriers and suspended in a cell culture medium which circulates in the devices with the hepatocytes (23). Blood or plasma passes on one side (7?) of semi-permeable membranes, on the other side (7) of which is the cell culture medium and across which is a concentration and/or pressure gradient. Solutes diffusing across the membrane into the cell culture medium are metabolized by the hepatocytes (23) and/or captured by additional removal means (4). Those undesirable substances which do not diffuse out of the blood or plasma into the hepatocyte containing culture medium are captured by additional removal means (50).
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: February 22, 2005
    Assignee: Xenogenics
    Inventors: Edward F. Myers, Albert P. Li, Achilles A. Demetriou
  • Patent number: 6858147
    Abstract: The process of heavy metals removal from the waste water using silica dispersion without mixing silica dispersion with the waste water. This is achieved due to the membrane device where silica dispersion and waste water stream are separated by membrane with pore sizes smaller that size of the silica particles. The process is organized as counter-flow, which means that silica dispersion and waste water flow in the opposite directions. This provides the maximum utilization of the adsorption capacity corresponding to the adsorbent being in equilibrium with the high initial concentration of the contaminant in distinction from the low utilization when adsorbent works in equilibrium with the low output concentration. In the particular instance the membrane device comprises a lumen of a bundle of hollow fibers with silica dispersion flowing either inside or outside of the fibers and wastewater flowing on the opposite side of the fiber membrane. This process eliminates step of separating silica from the wastewater.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: February 22, 2005
    Assignee: Dispersion Technology, Inc.
    Inventors: Andrei S. Dukhin, Stanislav Dukhin, Philip J. Goetz
  • Patent number: 6841074
    Abstract: A method of purifying an electrolyte by bringing the electrolyte into contact with a first effective surface of a separating unit that is permeable to contaminants to be removed from the electrolyte, and bringing a purifying liquid into contact with a second effective surface of the separating unit. A concentration level of contaminants in the purifying liquid is maintained to maintain a contaminant driving force gradient between the electrolyte and the purifying liquid so contaminants transfer from the electrolyte into the purifying liquid. An apparatus for purifying an electrolyte having a first volumetric region for holding the electrolyte, a second volumetric region for holding a purifying liquid, and a separating unit that is permeable to the contaminants to be removed from the electrolyte and which fluidically separates the first and second volumetric regions.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: January 11, 2005
    Assignee: Enthone-OMI (Deutschland) GmbH
    Inventors: Andreas Möbius, Axel König
  • Publication number: 20040256318
    Abstract: There is disclosed a separation device in which separation flow paths for allowing the passage of only molecules having a predetermined size and smaller sizes are disposed between two flow channels set apart by a partition; and a separation method using the device. According to the separation technique, substances having small sizes such as cells, nucleic acids and proteins can be separated by the use of a small amount of a sample in a short time with excellent resolution, and problems of clogging and the like can also be solved.
    Type: Application
    Filed: April 26, 2004
    Publication date: December 23, 2004
    Inventors: Kazuhiro Iida, Noriyuki Iguchi, Masakazu Baba, Hiroko Someya, Hisao Kawaura, Toru Sano, Toshitsugu Sakamoto
  • Publication number: 20040245175
    Abstract: A water treatment system and method including a membrane-based boron removal unit includes a boron analyzer for detecting the concentration of boron in a treatment stream. The boron removal unit can be a reverse osmosis (RO) or electrodeionization (EDI) treatment unit. A controller responds to the detected boron concentration to control an operation of the RO or EDI units. In an EDI system, the controller may adjust current or voltage supplied to match current to changes in ionic load and maintain a portion of the dilute cell in a substantially regenerated state. In an RO system, the controller may control the high pressure side flow rate, the brine blowdown rate, the product water permeation rate, pH, or feed rate of chemicals in response to the detected boron concentration value.
    Type: Application
    Filed: August 5, 2004
    Publication date: December 9, 2004
    Inventors: Richard D Godec, Robert J Ritz, William W Carson, Thomas J Susa
  • Publication number: 20040232077
    Abstract: The invention relates to a method for determining the binding behavior of ligands which specifically bind to target molecules at at least one binding site, whereby the markers are present in a native form and the determination of the concentrations K4 and K5 or of the quantities M2 and M1 is carried out by means of mass spectrometry.
    Type: Application
    Filed: November 15, 2003
    Publication date: November 25, 2004
    Inventors: Klaus Wanner, Georg Hofner, Wolf Bertling
  • Publication number: 20040217047
    Abstract: This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
    Type: Application
    Filed: May 28, 2004
    Publication date: November 4, 2004
    Inventors: David C. Bomberger, Bryan Chavez, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra, Jeffrey J. Shimon
  • Patent number: 6793825
    Abstract: The present invention relates to a process for separating from an aqueous mixture one or more organic substances containing at least one positively charged and/or chargeable nitrogenous group by means of extraction via at least one porous membrane, wherein use is made of an extraction agent which contains at least partially relatively long-chain organic compounds and at least one liquid cation exchanger, and of a membrane that is wettable by either the aqueous mixture or by the extraction agent.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: September 21, 2004
    Assignee: DSM IP Assets B.V.
    Inventors: Dietrich H. Maass, Dirk Weuster-Botz, Ralf Takors, Christian Wandrey, Holger Paschold
  • Publication number: 20040178147
    Abstract: A liquid-liquid extraction system including an outer chamber and an inner chamber. The outer chamber is adapted to contain one of a feed solution and a liquid extractant and defines a containment region. The inner chamber is adapted to contain the other of the feed solution and the liquid extractant within a lower portion of the inner chamber. The inner chamber is defined by a microporous membrane sleeve that internally maintains a frame. Upon final assembly, at least the lower portion of the inner chamber is positioned within the containment region of the outer chamber such that the microporous membrane sleeve establishes an extraction interface between contents of the inner and outer chambers. In one embodiment, the flow region of the microporous membrane sleeve is immersed within a feed solution otherwise contained within the outer chamber.
    Type: Application
    Filed: March 13, 2003
    Publication date: September 16, 2004
    Applicant: 3M Innovative Properties Company
    Inventors: Dan L. Fanselow, Todd W. Johnson
  • Publication number: 20040168981
    Abstract: Process for the separation of substances present in dissolved and/or colloidal form, in particular of catalysts, from solutions in a nonaqueous solvent, with the aid of a membrane, wherein the solution is passed through a membrane which has a hydrophobic coating and a mean pore size of not more than 30 nm.
    Type: Application
    Filed: February 9, 2004
    Publication date: September 2, 2004
    Applicant: Bayer Aktiengesellschaft
    Inventors: Gregor Dudziak, Andreas Nickel, Kerstin Baumarth, Martina Mutter, Olaf Strange, Rafael Warsitz
  • Patent number: 6783929
    Abstract: Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compatible with biological samples, for example, a cell line, a biological fluid such as blood, or a tissue cell lysate. The ligands may include affinity property groups and hydrophilic groups pendent from a backbone, and be configured to at least partially resolve components of a biological sample. Affinity supports in accordance with the present invention may be used in a variety of techniques and apparatuses to achieve improved separations of complex biological samples and thereby enhance the results of biological sample component fractionations, enrichments, purifications, expression product determinations and comparisons, and other biological sample processing techniques.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: August 31, 2004
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Eric Beausoleil, Matthew Wachowicz, Srinivas Kothakota
  • Patent number: 6773600
    Abstract: The invention relates to the field of protein purification and the recovery of large proteinaceous material through small, nanometer sized, pore exclusion filters for removal of contaminants such as viral pathogens.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 10, 2004
    Assignee: Cantocor, Inc.
    Inventors: Barry P. Rosenblatt, Richard C. Siegel
  • Publication number: 20040108269
    Abstract: The present invention describes a method for recovery of aqueous samples or components thereof from polymer packaging materials, wherein the spilled aqueous sample has been absorbed by the packaging material to form a liquid swollen absorbent gel. The method comprises the steps of contacting the liquid swollen absorbent gel with a recovery fluid, wherein the recovery fluid has a higher osmotic pressure than the aqueous sample.
    Type: Application
    Filed: July 8, 2003
    Publication date: June 10, 2004
    Inventors: Paschalis Alexandridis, Sriram Neelamegham
  • Patent number: 6716352
    Abstract: A process for removing and recovering undissociated aromatic amines dissolved in aqueous fluid comprises the steps of (a) transferring undissociated aromatic amines from the aqueous fluid to an acidic stripping solution across a membrane wherein the membrane is a non-porous, selectively permeable membrane; (b) regulating the volume of acidic stripping solution employed relative to the volume of aqueous fluid treated so that the total aromatic amine concentration in the acidic stripping solutions, comprising the sum of the dissociated and undissociated aromatic amine concentrations, is above the solubility of the aromatic amine in water; (c) regulating the pH of the acidic stripping solution in contact with the membrane so that the membrane remains selectively permeable; (d) adjusting the pH of the aromatic amine containing acidic stripping solution to a value above the acidic dissociation constant of the aromatic amine and (e) separating the resulting aromatic amine and the acidic stripping solution.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: April 6, 2004
    Assignee: Membrane Extraction Technology Limited
    Inventor: Andrew Guy Livingston
  • Publication number: 20040055955
    Abstract: Sodium chloride and purified water are recovered by treating salt water that contains sodium chloride with an integrated reverse osmosis and electrodialysis system, which includes an efficiency-enhancing feature that is one or more of the following: the use of univalent anion and univalent cation selective membranes in the electrodialysis unit; the addition of a nanofiltration unit to process the diluate from the electrodialysis unit; or operation of the electrodialysis unit at an elevated pressure. Magnesium and bromine can optionally be produced when the salt water contains these materials.
    Type: Application
    Filed: August 1, 2003
    Publication date: March 25, 2004
    Applicant: University of South Carolina
    Inventor: Thomas A. Davis
  • Patent number: 6708957
    Abstract: One or more aerators move below an area of an assembly of immersed filtering membranes to be aerated. The movement can take various forms including the sweep of a pendulum. Positions in the assembly of membranes may be alternately aerated for a period of time and then not aerated for a period of time.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: March 23, 2004
    Assignee: Zenon Environmental Inc.
    Inventors: Pierre Cote, Steven Pedersen, Denis Guibert
  • Publication number: 20040050787
    Abstract: A single- or multi-well sample preparation apparatus and method for desalting, concentrating and depositing samples prior to further analysis such as by MALDI TOF mass spectrometry. The apparatus in accordance with an embodiment of the present invention includes a plurality of wells each in fluid communication with a respective outlet or drainage opening, optionally containing a three dimensional membrane structure preferably comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. The apparatus is designed to allow for direct spotting onto a MALDI target, thereby eliminating a transfer step. Also disclosed is a method of sample preparation, deposition and analysis using the apparatus of the present invention.
    Type: Application
    Filed: September 13, 2002
    Publication date: March 18, 2004
    Inventors: Elena Chernokalskaya, Phillip Clark, William Kopaciewicz
  • Patent number: 6706189
    Abstract: An aeration system for a submerged membrane module has a set of aerators connected to an air blower, valves and a controller adapted to alternately provide a higher rate or air flow and a lower rate of air flow in repeated cycles. In an embodiment, the air blower, valves and controller, simultaneously provide the alternating air flow to two or more sets of aerators such that the total air flow is constant, allowing the blower to be operated at a constant speed. In another embodiment, the repeated cycles are of short duration. Transient flow conditions result in the tank water which helps avoid dead spaces and assists in agitating the membranes.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: March 16, 2004
    Assignee: Zenon Environmental Inc.
    Inventors: Hamid Rabie, Pierre Côté, Manwinder Singh, Arnold Janson
  • Publication number: 20040035792
    Abstract: The invention relates to a device and a method for separating undissolved constituents out of biological fluids, especially for separating blood plasma out of whole blood. It is to propose a simple and cost-effective way by means of which undissolved constituents can be separated out of biological fluids, in particular blood plasma out of whole blood, and the pure fluid is presenting then as a pure liquid volume without any substrate. To solve this object, e.g., whole blood is placed into a feed chamber. The feed chamber is isolated in an all-over manner by means of a membrane from a per se closed cavity having a small height. The cavity is connected to a flow channel or an opening from which the/the separated blood plasma can be removed.
    Type: Application
    Filed: August 27, 2003
    Publication date: February 26, 2004
    Inventors: Peter R Rauch, Andreas Katerkamp, Marco Schmitz, Frank Grawe
  • Publication number: 20040026322
    Abstract: The present invention relates to a process which can be carried out continuously for the adsorption separation of substances in liquid media, in which process a flat adsorbent is loaded with an adsorbate by contacting the adsorbate-containing medium with the entire adsorbing outer surface of the adsorbent without forced flow through, and to an apparatus for carrying out the inventive process.
    Type: Application
    Filed: June 12, 2003
    Publication date: February 12, 2004
    Applicant: Sartorius AG
    Inventors: Dietmar Nussbaumer, Wolfgang Demmer
  • Patent number: 6689615
    Abstract: Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically attractable particles bind the cellular components in a whole blood sample. Application of a magnetic field gradient to a container with the blood sample and the magnetically attractable particles draws the particles to the surface of the container near the source of the magnetic field gradient. The plasma can be removed and stored or used for monitoring or detecting analytes in the plasma.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: February 10, 2004
    Inventors: James Murto, Michael Salvati
  • Publication number: 20040011739
    Abstract: The invention concerns a method for separating a metal (1) from a metal (2), preferably zirconium from hafnium, which consists in dissolving said metals in an aqueous solution wherein said metals are in a state preventing them from passing through a nanofiltration membrane; treating the aqueous medium with a ligand, for example EDTA, which is complexed with metal (1) and/or metal (2), then in passing the resulting treated medium on a filtering membrane allowing through the ligand-metal complexes, but retaining the metals not complexed with the ligand.
    Type: Application
    Filed: June 19, 2003
    Publication date: January 22, 2004
    Inventors: Noel Ozanne, Marc Lionel Lemaire, Alain Jean-Louis Guy, Jacques Henri Foos, Stephane Pellet-Rostaing, Frederic Chitry
  • Publication number: 20040011723
    Abstract: A filtration membrane and method of making the same wherein the filtration membrane comprises obstructions and/or spacers.
    Type: Application
    Filed: March 5, 2003
    Publication date: January 22, 2004
    Inventors: Wesley L. Bradford, Rodney E. Herrington, Allen D. Clement
  • Publication number: 20040004039
    Abstract: A molecule separator device for isolating molecules having at least two separable properties and within a solution. The device includes a housing, and at least two molecule collection media disposed within the housing, whereby each such medium captures molecules exhibiting a respective property. In one embodiment, a first membrane captures only molecules with an ionic and/or hydrophobic and/or affinity attraction property while a second membrane captures only such molecules that additionally fall within a particular molecular weight range. A preferred housing is cylindrical for acceptance within a centrifuge, and is constructed of a plurality of releasably-connected compartments. The collection media is sequentially situated and centrifugation of the housing drives the solution through the media.
    Type: Application
    Filed: June 12, 2003
    Publication date: January 8, 2004
    Inventor: Timothy Neal Warner
  • Publication number: 20030230532
    Abstract: The invention relates to the field of protein purification and the recovery of large proteinaceous material through small, nanometer sized, pore exclusion filters for removal of contaminants such as viral pathogens.
    Type: Application
    Filed: June 4, 2003
    Publication date: December 18, 2003
    Inventors: Barry P. Rosenblatt, Richard C. Siegel
  • Patent number: 6649062
    Abstract: A process for the separation of mixture components uses a supercritical fluid that is fresh to at least one side of a nonporous membrane after which the fluid is either recycled to the opposite side of the membrane or removed from the separation process. Fluids and membranes, including modified membranes, are provided to facilitate passage of one or more components of a mixture through the membrane while retarding passage of other components of the mixture. The process is useful for the separation of mixtures with similar components including axeotropic mixtures and pharmaceutical and biological products.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: November 18, 2003
    Inventor: Stephen E. Petty
  • Publication number: 20030209492
    Abstract: Processes and apparatus are disclosed for separating and purifying aqueous solutions such as seawater by causing a substantially impermeable mat of gas hydrate to form on a porous restraint. Once the mat of gas hydrate has formed on the porous restraint, the portion of the mat of gas hydrate adjacent to the restraint is caused to dissociate and flow through the restraint, e.g., by lowering the pressure in a collection region on the opposite side of the restraint. The purified or desalinated water may then be recovered from the collection region. The process may be used for marine desalination as well as for drying wet gas and hydrocarbon solutions. If conditions in the solution are not conductive to forming hydrate, a heated or refrigerated porous restraint may be used to create hydrate-forming conditions near the restraint, thereby causing gas hydrates to form directly on the surface of the restraint.
    Type: Application
    Filed: May 6, 2003
    Publication date: November 13, 2003
    Inventor: Michael D. Max
  • Publication number: 20030192828
    Abstract: A charge mosaic membrane having excellent selective permeability comprises a cationic polymer component, an anionic polymer component and a matrix component. Both of the cationic polymer component and the anionic polymer component are crosslinked particulate polymers. The matrix component is at least one polymer selected from a polysulfone resin, a polyarylate resin, a polyamide resin, a polyimide resin, a polyamideimide resin, a polyurethane resin, a fluorinated resin or a silicone resin. The charge mosaic membrane can be easily produced by conducting formation of the membrane by using a composition in which the cationic polymer component and the anionic polymer component are both dispersed in a solution of the matrix component in an organic solvent.
    Type: Application
    Filed: February 22, 1999
    Publication date: October 16, 2003
    Inventors: TAKASHI FUKUTOMI, YOSHIFUMI SUGITO, MINORU TAKIZAWA, NAOMI OGUMA, SEIJI DOI, MICHIEI NAKAMURA
  • Patent number: 6602502
    Abstract: Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoactive substances as haptens and utilizing their protein conjugates to produce antibodies to the psychoactive materials themselves. The immunoassay methods include both agglutination and agglutination-inhibition reactions. The treatment methods include treatment of both exogenous, administered drugs (such as cannabinols, LSD, heroin and morphine) endogenous substances (such as N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: August 5, 2003
    Inventor: Meir Strahilevitz
  • Publication number: 20030121854
    Abstract: The present invention is directed to novel methods for enhancing the ability to separate a species of interest from other different species present in a free solution mixture thereof which takes advantage of interactions that occur between soluble, small molecular weight ligands and the species of interest. The small molecular weight ligands employed in the present invention function to interact with a species of interest in a mixture of different species through either affinity, hydrophobic and/or ionic interactions, thereby altering the molecular weight, hydrodynamic volume and/or isoelectric point of the species of interest and rendering it separable from other component(s) in the mixture.
    Type: Application
    Filed: November 18, 2002
    Publication date: July 3, 2003
    Inventor: Robert Van Reis
  • Patent number: 6582607
    Abstract: Process for dewatering organic liquids admixed with water wherein the admixture is brought into contact with a molecular sieve. The moleculat sieve is pretreated so as to reduce its acid site concentration and attain an ammonia TPD value of 18 mmol/g or less prior to contact with the admixture. The present invention relates to a process for dewatering organic liquids admixed with water, said process comprising bringing the admixture into contact with a molecular sieve, characterized in that the molecular sieve is pretreated so as to reduce its acid site concentration and attain an ammonia TPD value of 18 mmol/g or less prior to contact with the admixture.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: June 24, 2003
    Assignee: BP Chemicals Limited
    Inventors: Eric Nicholas Coker, Richard Duncan Oldroyd, Warren John Smith
  • Publication number: 20030102261
    Abstract: A method of purifying a mixture, said mixture comprising an oil Product, at least one additive and water, wherein: said oil Product is a liquid fuel oil composition or lubricating oil composition, at least part of the water is in the form of a dispersion of water in said Product, and said additive is a cyclic compound comprising m units of the formula (Ia) and n units of the formula (Ib) joined together to form a ring, wherein each y and Y2 is a divalent bridging group which may be the same or different in each unit; R0 is H or (C1-C6) alkyl or is a metal cation, R5 is H or (C1-C60) alkyl; J is 1 or 2; R3 is hydrogen, a hydrocarbyl or a hetero-substituted hydrocarbyl group; either R1 is hydroxyl and R2 and R4 are independently either hydrogen, hydrocarbyl or heterosubstituted hydrocarbyl, or R2 or R4 are hydroxyl and R1 is either hydrogen, hydrocarbyl or hetero-substituted hydrocarbyl; and m+n is from 4 to 20, m is from 1 to 8 and n is at least 3; said method comprising: providing said mixture, coalescin
    Type: Application
    Filed: August 29, 2002
    Publication date: June 5, 2003
    Inventors: Anthony Spencer Ford, James Alexander Mitchell, Spencer Edwin Taylor
  • Patent number: 6569341
    Abstract: A method of raising the concentration of a liquid mixture utilizes osmotic distillation to transfer a volatile liquid component from the mixture in contact with one side of a nonporous, preferably high free volume, gas permeable membrane to a strip solution in contact with the other side of the membrane. Due to its nonporous nature the gas permeable membrane resists penetration and wetting by oily components that may be present in the feed mixture. Similarly, occlusion of the membrane by solids is resisted. Preferably, an amorphous copolymer of perfluoro-2,2-dimethyl-1,3-dioxole is useful for the gas permeable membrane. Osmotic distillation utilizing such high free volume, nonporous gas permeable membranes can concentrate difficult liquid mixtures such as pulpy fruit juices and especially, limonene-containing juices, for example, orange juice. The process can be operated at high flux for long durations between membrane cleanings.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: May 27, 2003
    Assignee: CMS Technology Holdings, Inc.
    Inventor: John J. Bowser
  • Patent number: 6565749
    Abstract: A filter for removing microorganisms from a fluid is provided by the invention. The filter includes a substrate having a reactive surface, and a polymer covalently bonded to the reactive surface of the substrate. The polymer includes a plurality of cationic groups for attracting microorganisms. Faucet mounted filters and pour through filters containing the polymer coated substrate are provided. Also disclosed are methods for using and manufacturing filters for removing microorganisms from a fluid.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: May 20, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Kenneth C. Hou, Donald S. Bretl, Richard D. Hembree