Utilizing Paper Or Thin Layer Plate Patents (Class 210/658)
  • Patent number: 11059262
    Abstract: The present invention relates to a method of preparing an aerogel blanket in which, a surface of a base material for a blanket is activated and roughness and porosity of the surface of the base material for a blanket are increased to increase adhesion performance of a silica aerogel by inducing etching of a surface of a base material for a blanket using an acidic solution, and mechanical flexibility is increased and the generation of dust is minimized by further performing a gel deformation process of introducing cracks into the aerogel, and a low-dust and high-insulation aerogel blanket prepared according to the present invention.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: July 13, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Kyoung Shil Oh, Je Kyun Lee, Dong Sik Bae, Jeong Hun Son
  • Patent number: 10466237
    Abstract: An object is to provide an immunochromatography detection method and an immunochromatography kit in which a prozone phenomenon occurring in a sandwich method when using an analyte in which an antigen is present in a large excess amount is suppressed/excluded. The object was achieved by retaining a nonionic and hydrophilic surfactant having an HLB value of 13 to 18 in a sample addition part of an immunochromatography device, and also using a membrane having a fast flow speed as a membrane to be used for a chromatograph medium.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: November 5, 2019
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita Suzuki, Hisahiko Iwamoto
  • Patent number: 10215679
    Abstract: A thin-layer chromatography device can be used to determine or select a surfactant solution for use during hydrocarbon-fluid production operations. The thin-layer chromatography device can include a chamber that can receive a surfactant solution that includes a surfactant and a fluid. The thin-layer chromatography device can also include a substrate that can be coated with a layer of adsorbent material to form a thin-layer substrate and a hydrocarbon fluid can be disposed on the thin-layer substrate. The thin-layer substrate, along with the hydrocarbon fluid, can be positioned within the chamber to determine a mobility index of the hydrocarbon fluid when the hydrocarbon fluid contacts the surfactant solution. The mobility index can indicate an eluting capability of the surfactant solution with respect to the hydrocarbon fluid and can be used to select the surfactant solution to be injected into a wellbore that includes the hydrocarbon fluid to enhance hydrocarbon-fluid production operations.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: February 26, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Tatyana V. Khamatnurova, Jeremy Holtsclaw, Kristina Henkel Holan
  • Patent number: 9805931
    Abstract: Methods for processing of a workpiece are disclosed. A fluid that contains a desired dopant is prepared. The workpiece is immersed in this fluid, such that the dopant is able to contact all surfaces of the workpiece. The fluid is then evacuated, leaving behind the dopant on the workpiece. The dopant is then subjected to a thermal treatment to drive the dopant into the surfaces of the workpiece. In certain embodiments, a selective doping process may be performed by applying a mask to certain surfaces prior to immersing the workpiece in the fluid. In certain embodiments, the fluid may be in a super-critical state to maximize the contact between the dopant and the workpiece.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: October 31, 2017
    Assignee: Varian Semiconductor Equipment Associates, Inc.
    Inventors: Frank Sinclair, Jay T. Scheuer, William Davis Lee, Peter L. Kellerman
  • Patent number: 9618487
    Abstract: Prefilled liquid cartridge for fluidically connecting to a sample separation device for separating of components of a fluidic sample by using liquid of the liquid cartridge, wherein the liquid cartridge comprises a liquid container which is prefilled with liquid and a liquid removal access provided at the liquid container, adapted to be fluidically coupled with at least one liquid conduit of the sample separation device by only inserting the liquid cartridge in a corresponding liquid cartridge accommodation of the sample separation device.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: April 11, 2017
    Assignee: Agilent Technology, Inc.
    Inventors: Manuela Senf, Daniela Loraing, Qi Siegmundt-Pan
  • Patent number: 9399786
    Abstract: The present invention relates to a test system or assay system (detection system) and to a test method, preferably in use in the point-of-care (PoC) field.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: July 26, 2016
    Assignee: DST Diagnostische Systeme & Technologien GmbH
    Inventors: Lars Von Olleschikelbheim, Mark Hünken, Marc Dangers
  • Patent number: 9234881
    Abstract: A thin-layer chromatography plate and a thin-layer chromatography uses a thin-layer chromatography plate that has a first separating agent layer, which has the same optical response as the sample, and a second separating agent layer, which is disposed adjacent thereto and has an optical response that is different from the aforementioned optical response; carries out development of the sample in the first separating agent layer; thereafter carries out further development of the spots from the first separating agent layer toward the second separating agent layer; and detects the spots in the second separating agent layer through exposure to ultraviolet radiation or a color-development treatment with a coloring agent.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: January 12, 2016
    Assignee: DAICEL CORPORATION
    Inventors: Toshiharu Minoda, Isamu Ikeda, Satoru Nose, Noriaki Takeya, Ichiro Okamoto
  • Patent number: 9126227
    Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the TLC plate. Embodiments for TLC plates and related methods are also disclosed.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: September 8, 2015
    Assignees: US SYNTHETIC CORPORATION, BRIGHAM YOUNG UNIVERSITY
    Inventors: Matthew R. Linford, David Scott Jensen, Andrew E. Dadson, Robert C. Davis
  • Publication number: 20150027950
    Abstract: A method is described to treat atherosclerosis by extracorporeally treating a patient's blood. A patient's blood is treated extracorporeally using a moiety that targets an antigen in the blood. The moiety facilitates removal of the blood antigen. The cleansed blood is then returned to the patient.
    Type: Application
    Filed: March 19, 2013
    Publication date: January 29, 2015
    Inventor: Mitchell S. Felder
  • Publication number: 20140224740
    Abstract: Reversed phase solid silica gel sorbent layers which can adhere with appropriate binders to a solid surface were developed. Pre-coated RP-rotors of different thickness were used These pre-coated RP-rotors can be used for Centrifugal Preparative Thin-layer Chromatography (CPTLC) using any appropriate device for Centrifugal Chromatography, like Chromatotron® or Cyclograph. Organic compounds including very polar ones can be separated and/or purified in a preparative scale from mixtures by these pre-coated RP-rotors, using different solvent systems. Also described is a new chromatographic separating device (hereinafter Chromato Rotor) and a method for separation of constituents from natural products or mixture of organic compounds using a centrifugal preparative chromatographic instrument with a separating element which contains a binder free sorbent layer packed or loaded between two supporting rotors and retained from moving outside by a porous filter. Only eluants pass through.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 14, 2014
    Inventors: Muhammad Ilias, Volodymyr Samoylenko, Van Douglas Gillum
  • Patent number: 8702984
    Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the TLC plate. Embodiments for TLC plates and related methods are also disclosed.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: April 22, 2014
    Assignees: US Synthetic Corporation, Brigham Young University
    Inventors: Matthew R. Linford, David Scott Jensen, Andrew E. Dadson, Robert C. Davis
  • Publication number: 20130319086
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
    Type: Application
    Filed: January 25, 2013
    Publication date: December 5, 2013
    Applicant: Waters Technologies Corporation
    Inventors: Kevin Daniel Wyndham, Pamela C. Iraneta, Thomas H. Walter
  • Patent number: 8568587
    Abstract: A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: October 29, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Susan V. Olesik, Jonathan E. Clark, Jeremy K. Steach, Joseph W. Zewe
  • Patent number: 8506802
    Abstract: Stackable planar adsorption devices include a plurality of layers of adsorptive media provided in a web format. The layers are stacked in contiguous fashion, sealed and include fluid passageways to provide a range of scalable chromatography devices suitable for large scale manufacturing applications.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: August 13, 2013
    Assignee: Gaston de los Reyes
    Inventor: Gastón de los Reyes
  • Patent number: 8507037
    Abstract: Printing one or more layers using toner and/or laminates to form one or more multi-channeled layers, with a particular pattern, including forming a desired image, for example, electrographically, on a receiver member. The multi layered channel printing apparatus and related method and print incorporates one or more static layers, and one or more moveable layers that allow a fluid to move through the micro channels via an opening or through a direct fill. It also incorporates particles in the channels to act as a packing material for separation of components of samples. The packing material can either be applied directly or using the electrographic printing process. An optional capping layer or substrate may then be applied.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: August 13, 2013
    Assignee: Eastman Kodak Company
    Inventors: Lee W. Tutt, Donna P. Suchy
  • Patent number: 8476075
    Abstract: A method of estimating the amount of unreacted starting materials (glycerides, methyl esters, etc.) and the composition of a biodiesel using TLC in conjunction with a lipophilic dye, Nile Red is described herein. The dye based TLC method of the present invention is convenient and provides significant advantages over existing methods for estimating the purity of a biodiesel composition.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 2, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eva Deemer, Wen Yee Lee, Xiomara Carolina Chianelli
  • Patent number: 8293111
    Abstract: Methods and apparatuses for chromatography are provided, using, for example, water as a stationary phase and carbon dioxide as the mobile phase.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: October 23, 2012
    Assignee: UTI Limited Partnership
    Inventor: Kevin B. Thurbide
  • Patent number: 7892847
    Abstract: A countercurrent chromatography apparatus includes a plurality of plates, at least one plate (16) having first and second interleaved spiral flow channels (52, 54, 56, 58) therein. Each spiral flow channels (52, 54, 56, 58) has a first end (I1, I2, I3, I4) near the central axis and a second ends (O1, O2, O3, O4) near the periphery. The outlet of the first channel (O1) is connected to the inlet of the second channel (I2) by a connecting channel (72). Septa may be provided between the plates to connect the spiral channels of one plate to the spiral channels of the next plate.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: February 22, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Yoichiro Ito
  • Publication number: 20110000852
    Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. Embodiments for TLC plates and related methods are also disclosed.
    Type: Application
    Filed: June 30, 2010
    Publication date: January 6, 2011
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Matthew R. LINFORD, Robert C. DAVIS, Richard R. VANFLEET, David JENSEN, Li YANG
  • Patent number: 7736517
    Abstract: According to one aspect of the disclosure, there is provided an apparatus (210) for performing electrochromatography. The apparatus (210) includes a die block (222) which is movable to exert a pressure greater than atmospheric pressure on a chromatography sample plate during performance of an electrochromatography procedure. A method of performing electrochromatography is also disclosed.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: June 15, 2010
    Assignees: Indiana University Research and Technology Corporation, Purdue Research Foundation
    Inventors: David Nurok, Robert E. Santini, Randall W. Replogle, Gregory L. Hawkins, Henry L. Hawkins, legal representative, James M. Koers
  • Publication number: 20100065501
    Abstract: A cross-corrugated structure packing module is provided for use in mass transfer or heat exchange columns and has particular applicability in severe service applications in which fouling, coking, and erosion are of concern. The structured packing module has a plurality of upright, parallel-extending, corrugated plates. Spacer elements are used to maintain the corrugations of adjacent plates in spaced apart relationship to reduce the opportunity for solids to accumulate on the surfaces of the plates. The plates are also free of apertures or surface treatments that would increase the opportunity for solids to accumulate on the plates.
    Type: Application
    Filed: September 16, 2009
    Publication date: March 18, 2010
    Applicant: KOCH-GLITSCH, LP
    Inventors: Izak Nieuwoudt, Michael James Lockett
  • Publication number: 20100048973
    Abstract: Process for separation of a feedstock F by adsorption in a simulated moving bed in an SMB device that comprises a zone 1 for desorption of compounds produced by extraction, a zone 2 for desorption of compounds produced with a raffinate, a zone 3 for adsorption of compounds produced by extraction, and a zone 4 that is located between the draw-off of the raffinate and the supply of the desorbent, whereby the device comprises external bypass lines Li/i+1 directly joining two successive plates Pi, Pi+, that are equipped with non-automated means for adjusting flow rate and closing means, in which the degree of opening of the restriction means of the scavenging flow rate of the bypass lines Li/i+1 is adjusted so as to obtain the best performance of the SMB.
    Type: Application
    Filed: August 18, 2009
    Publication date: February 25, 2010
    Applicant: IFP
    Inventors: Xavier DECOODT, Gerard HOTIER, Philibert LEFLAIVE, Damien LEINEKUGEL LE COCQ
  • Publication number: 20100006502
    Abstract: A discrete drop dispensing device comprises a substrate comprising an upper surface and a lower surface and orifices extending from the upper surface to the lower surface, adapted to receive a fluid at a flow rate. The discrete drop dispensing device also comprises an oscillator disposed adjacent to the substrate and configured to vibrate the substrate to expel drops having a substantially equal volume of the fluid. The flow rate is substantially identical to a drop dispensing rate. A method and a device for performing liquid chromatography are also described. The method comprises automatically adjusting the drop dispensing rate to a change in the flow rate or a change in a composition of a mobile phase of the fluid.
    Type: Application
    Filed: July 10, 2008
    Publication date: January 14, 2010
    Inventor: Arthur Schliefer
  • Patent number: 7628915
    Abstract: A composition for use in chromatography is provided comprising a substrate modified with a metal-cyano bonded phase. This novel cyano bonded phase provides superior performance in high performance liquid chromatography (HPLC) and provides superior selectivity, improved peak shape for basic analytes, and the ability of provide rapid separation with outstanding resolution. The composition exhibits improved storage stability, and is chemically stable over a range of pH from 1.5 to 7.5 mobile phase conditions and for more than 2000 multiple injections. A baseline separation of eight tricyclic antidepressants was achieved in less than four minutes using an isocratic mobile phase with the metal-cyano bonded phase of the present invention, compared to the long retention times and poor separation observed for traditional cyano bonded phase. The composition of this invention is particularly useful in a wide variety of chromatographic applications.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: December 8, 2009
    Assignee: Varian, Inc.
    Inventors: Guang Qing Li, Yonglong Andrew Li
  • Publication number: 20090179146
    Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.
    Type: Application
    Filed: January 19, 2006
    Publication date: July 16, 2009
    Inventors: Lee O. Lomas, Jian Ding, Egisto Boschetti
  • Publication number: 20090166294
    Abstract: Sample is applied to a chromatographic column containing shape stabilized packing and the liquid phase is pumped through the shape stabilized packing at a rate of flow greater than the standard rate of flow to obtain at least one of a target resolution and target time of run. Because of the improved resolution provided by the shape stabilized packing at higher rates of flow of solvent, the chromatographer can either obtain better resolution with a standard gradient or shorten the time of the run and reduce the amount of solvent needed by increasing the slope of the gradient.
    Type: Application
    Filed: January 4, 2009
    Publication date: July 2, 2009
    Inventors: Dale A. Davison, Ruth A. Pipes, Jack E. Silver
  • Patent number: 7540184
    Abstract: It is an object of the present invention to provide a method capable of easily identifying a coloring material composition. The method performs a chromatography step of loading a subject sample containing the coloring material composition to a chromatography apparatus that holds a separating base material containing a cellulosic material and a metallic oxide material, and of performing a chromatography using a mobile phase of a liquid in the analysis of the coloring material composition. According to such a chromatography apparatus, coloring materials contained in the coloring material composition can be favorably and easily separated.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: June 2, 2009
    Assignee: Seiko Epson Corporation
    Inventors: Satomi Yoshioka, Shigeki Shimizu
  • Patent number: 7485118
    Abstract: The present invention relates to a microstructure arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids. The arrangement has an inlet for the arrangement to be connected to a system for the supply of liquids and at least one outlet for the arrangement to be connected to the at least one liquid-discharging system. The arrangement has a transition region, through which the liquid can be transported from the inlet to the at least one outlet. At a start of the transition region, at least one first microstructure element for producing a point with increased capillary force is provided, in order to achieve gap-free wetting of the areas bounding this point with increased capillary force, in particular side walls, a cover and/or a bottom.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: February 3, 2009
    Assignee: Boehringer Ingelholm Microparts GmbH
    Inventors: Gert Blankenstein, Ralf-Peter Peters, Claus Marquordt
  • Publication number: 20080272053
    Abstract: A renewable chromatography structure and methods of the invention for manipulating and trapping small particles within microfluidic systems enable providing surface-functionalized particles that are smaller than the fluidic tolerances of the microfluidic column. Particles of varied chemistry are then utilized for physical or mechanical packing, filtration, separations, modifying fluidic or flow properties of the renewable chromatography column.
    Type: Application
    Filed: May 1, 2007
    Publication date: November 6, 2008
    Inventor: Darrell P. Chandler
  • Publication number: 20080230479
    Abstract: A liquid chromatograph control apparatus for controlling the solvent mixing ratios of liquid chromatography, comprising a storage means for storing the correspondence relationship between the plural discrete Rf values obtained by thin layer chromatography performed on respective samples at a preset solvent mixing ratio and the appropriate sequences of solvent mixing ratios of liquid chromatography for the respective samples; an arithmetic means for obtaining, by interpolation, the appropriate sequence of solvent mixing ratios corresponding to any Rf value falling between the stored Rf values adjacent to each other; and an image processing means for imaging the thin layer plates obtained by performing thin layer chromatography, to obtain Rf values from the images.
    Type: Application
    Filed: March 20, 2008
    Publication date: September 25, 2008
    Applicant: MORITEX CORPORATION
    Inventors: Keigo Suzuki, Keisuke Abe
  • Publication number: 20080223787
    Abstract: In a liquid chromatographic system, removing at least part of a volatile component from the liquid sample stream after separation by flowing it through a volatile component-removal device including a porous wall having a surface coating of a permeable polymer less than 10 ?m thick. A liquid chromatographic system suitable for performing the method. Also, a liquid chromatographic system in which volatile component is removed prior to separation across the same type of membrane or across a membrane made of a copolymer of perfluoro-2,2-dimethyl-1,3-dioxole.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 18, 2008
    Applicant: Dionex Corporation
    Inventors: Purnendu K. Dasgupta, S.M. Rahmat Ullah, Kannan Srinivasan
  • Publication number: 20080203028
    Abstract: An iridium complex Ir(III)L 1L2L3 for emitting light with a central iridium ion Ir(III), with a ligand L3 as dionate from the group comprising pentane-2,4-dionate (acac), 2,2,6,6-tetramethyl-3,5-heptandionate (thd), 7,7-dimethyl-1,1,1,2,2,3,3-heptyfluoro-4,6-octandionate (fod), 4,4,4-trifluorol-(2-thienyl)butane-1,3-dionate (ttfa), 1,3-diphenylpropane-1,3-dionate (dbm), 4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dionate (tfnb) or 4,4,4-trifluoro-1-(1-naphthyl)butane-1,3-dionate and with two rigid aromatic ligands L1 and L2 with one nitrogen and one carbon atom, sharing in the ligand bond, preferably dibenzo[f,h]chinoline, benzo[h]chinoline or 5,6-dihydro-benzo[h]chinoline, characterized in that the iridium complex Ir(III)L1L2L3 is a first isomer (71), in which the nitrogen atom of the ligand L1 sharing in the ligand bonding and the nitrogen atom of the ligand L2 sharing in the ligand bonding are juxtaposed relative to the central iridium ion.
    Type: Application
    Filed: February 14, 2006
    Publication date: August 28, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Herbert Friedrich Boerner, Elena Popova, Josef Salbeck
  • Publication number: 20080135485
    Abstract: A composition for use in chromatography is provided comprising a substrate modified with a metal-cyano bonded phase. This novel cyano bonded phase provides superior performance in high performance liquid chromatography (HPLC) and provides superior selectivity, improved peak shape for basic analytes, and the ability of provide rapid separation with outstanding resolution. The composition exhibits improved storage stability, and is chemically stable over a range of pH from 1.5 to 7.5 mobile phase conditions and for more than 2000 multiple injections. A baseline separation of eight tricyclic antidepressants was achieved in less than four minutes using an isocratic mobile phase with the metal-cyano bonded phase of the present invention, compared to the long retention times and poor separation observed for traditional cyano bonded phase. The composition of this invention is particularly useful in a wide variety of chromatographic applications.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 12, 2008
    Inventors: Guang Qing Li, Yonglong Andrew Li
  • Publication number: 20080128358
    Abstract: The present invention relates to a process which can be carried out continuously for the adsorption separation of substances in liquid media, in which process a flat adsorbent is loaded with an adsorbate by contacting the adsorbate-containing medium with the entire adsorbing outer surface of the adsorbent without forced flow through, and to an apparatus for carrying out the inventive process.
    Type: Application
    Filed: October 25, 2007
    Publication date: June 5, 2008
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Dietmar Nussbaumer, Wolfgang Demmer
  • Patent number: 7279105
    Abstract: An arrangement for performing chromatography with a mobile phase and a chromatographic bed having a stationary phase is provided. The arrangement includes a support assembly configured to support the stationary phase. The support assembly has a sealed cavity configured so that when the support assembly is supporting the stationary phase a portion of the chromatographic bed and the stationary phase extends into the sealed cavity. The arrangement further includes a bladder having a void defined therein. The bladder is positioned within the sealed cavity. The arrangement also includes a fluid positioned within the void of the bladder so that the bladder is urged toward the stationary phase within the sealed cavity. The arrangement further includes an anode positioned in contact with the mobile phase.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: October 9, 2007
    Assignee: Indiana University Research and Technology Corporation
    Inventors: David Nurok, Megan Frost
  • Patent number: 6884346
    Abstract: A separation column and a method of making the separation column are provided. The separation column includes a separation channel and a separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a support and a stationary phase. The support includes a metal organic polymer, such as a photopolymer, and the stationary phase includes a bonded phase. The separation medium can be used to separate a sample of analytes.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: April 26, 2005
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson Bennett
  • Patent number: 6875348
    Abstract: A separation column and a method of preparing the separation column are provided. The separation column includes a separation channel and a porous matrix in the channel. The porous matrix includes a metal organic polymer, such as a photopolymer. The porous matrix can be a separation medium adapted to separate a sample of analytes or a frit adapted to retain a separation medium in the channel.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: April 5, 2005
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson D. Bennett
  • Patent number: 6866785
    Abstract: A separation column and a method of making the separation column are provided. The separation column includes a separation channel and fritless separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a metal organic polymer, such as a photopolymer. The separation medium can be used to separate a sample of analytes.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: March 15, 2005
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson Bennett
  • Patent number: 6803200
    Abstract: The present invention relates to compositions and methods for releasing nucleic acid molecules from solid matrices. The invention further relates to compositions and methods for purifying and isolating nucleic acid molecules from biological materials such as animal tissues and plant matter. The methods of the invention can be readily adapted for rapid processing of multiple samples. Thus, the invention further provides automated methods for the purification of nucleic acid molecules from numerous samples. The invention also relates to kits for removing nucleic acid molecules from solid matrices.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: October 12, 2004
    Assignee: Invitrogen Corporation
    Inventors: Jiu-Lin Xia, Mindy D. Goldsborough, Michael A. Connolly, Gulilat Gebeyehu
  • Patent number: 6787366
    Abstract: A method, system and kit for detecting the presence of an analyte includes placing a solution containing the analyte in a microcapillary tube and placing the microcapillary tube in contact with a layer of sorbent material so that the solution is withdrawn from the microcapillary tube by capillary action. A detector reagent which has been pre-deposited on the sorbent material indicates the presence of the analyte. The sorbent material, detector reagent, and the solvent for the analyte solution are selected so that the solvent is absorbed into the sorbent material and the analyte is adsorbed by the sorbent material and concentrated at the spot where the detector reagent has been pre-deposited and where the microcapillary tube contacts the sorbent material.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: September 7, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Thaddeus John Novak
  • Patent number: 6783988
    Abstract: A highly sensitive and specific method for the detection and quantification of lipids is provided. Specifically, methods for the simultaneous detection and quantification of phospholipids extracted from mammalian tissues is described. The analytical methods provided disclose a modified one-dimensional thin-layer chromatography technique specifically developed to rapidly and accurantely detect and quantify phospholipids from mammalian cardiac tissues.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: August 31, 2004
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tan Thanh Dinh, Patrice Tremble, Crystal M. Cunanan, Christine May Cabiling
  • Patent number: 6762057
    Abstract: A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed from a material such as porous silicon. Alternatively, the capillary column may have a rough surface of hemispherical grain silicon. The capillary column is defined in a surface of a substrate, such as silicon. The sample separation apparatus may include a stationary phase or a capture substrate disposed on the surfaces thereof. The sample separation apparatus may also include a detector positioned proximate the capillary column. A variation of the sample separation apparatus includes an electrode proximate each end of the capillary column. The sample separation apparatus may be employed to effect various types of chromatographic separation, electrophoretic separation, and analyte identification.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: July 13, 2004
    Assignee: Micron Technology, Inc.
    Inventor: Terry L. Gilton
  • Patent number: 6749756
    Abstract: A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: June 15, 2004
    Assignee: University of Pittsburgh
    Inventors: Dennis P. Curran, Oscar de Frutos Garcia, Yoji Oderaotoshi
  • Publication number: 20040087034
    Abstract: A test strip is constructed to include a substrate, a first sample-collection pad adhered to one side of the substrate, the first sample-collection pad having a side notch forming with the substrate a blood sample receiving chamber, and a second sample-collection pad adhered to the outer surface of the first sample-collection pad in parallel to the substrate and defining a blood sample entrance accessible to the blood sample receiving chamber.
    Type: Application
    Filed: October 30, 2002
    Publication date: May 6, 2004
    Inventor: Ching Ho Lien
  • Patent number: 6712972
    Abstract: The present invention provides an innovative method based on reaction cum separation on single plate concept for efficient evaluation of porphyrins, calix(4)pyrroles and allied macrocycles by in-situ synthesis from pyrrole with aromatic aldehydes and ketones over zeolite based molecular sieve catalysts as sorbents in thin layer chromatography (TLC) using microwave heating. This glass backed zeolite coated TLC plate acts as a micro reactor as well as separator for the in-situ synthesis and chromatographic separation of macrocycles. The process is simple, economical, rapid, selective and finds a possible application in high throughput parallel synthesis and screening on a single micro plate employing microwave irradiation.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: March 30, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sita Devi Pothuri, Kondapuram Vijaya Raghavan, Shivanand Janardan Kulkarni, Radha Kishan Motkuri, Radha Rani Vippagunta, Mamidanna Rama Venkata Satyanarayana Murty
  • Patent number: 6709584
    Abstract: A device for analyzing substances by thin layer chromatography comprises a solvent trough with two solvent channels, wherein two wall plates are mounted in the solvent trough, enabling thin layer plates to be arranged obliquely with respect to the horizontal in the solvent channels. The substance to be analyzed can thus be dropped or applied onto the thin layer plates from above, and solvent can be supplied to the solvent channels from above at a solvent supply point. The upward migration of components of the substance to be analyzed can thus be started without changing the position of the thin layer plate for this purpose.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: March 23, 2004
    Assignee: Chemspeed Ltd.
    Inventors: Rolf Güller, Séraphin Munch, Philippe Jablonski, Josef Schröer
  • Patent number: 6610202
    Abstract: An arrangement for performing chromatography with a mobile phase and a chromatographic bed having a stationary phase is provided. The arrangement includes a support assembly configured to support the stationary phase. The support assembly has a sealed cavity configured so that when the support assembly is supporting the stationary phase a portion of the chromatographic bed and the stationary phase extends into the sealed cavity. The arrangement further includes a bladder having a void defined therein. The bladder is positioned within the sealed cavity. The arrangement also includes a fluid positioned within the void of the bladder so that the bladder is urged toward the stationary phase within the sealed cavity. The arrangement further includes an anode positioned in contact with the mobile phase.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: August 26, 2003
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: David Nurok, Megan Frost
  • Publication number: 20030054567
    Abstract: In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source (201) to a chromatography test strip (8) is formed into an elliptical shape by an optical means such as a cylindrical lens (205), a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part (82) and a detection part (83), and a measurement is automatically started in a prescribed period of time since the detection of variation.
    Type: Application
    Filed: August 22, 2002
    Publication date: March 20, 2003
    Inventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
  • Publication number: 20030013187
    Abstract: A device according to the invention for analyzing substances by means of thin layer chromatography comprises a solvent trough (1) with two solvent channels (11, 12). Two wall plates (4, 5) are mounted in the solvent trough (1), enabling thin layer plates (2, 3) to be arranged standing obliquely with respect to the horizontal in the solvent channels (11, 12). The substance to be analyzed can thus be dropped or applied onto the thin layer plates (2, 3) from above, and solvent can be supplied to the solvent channels (11, 12) from above at a solvent supply point (111, 121). The upward migration of components of the substance to be analyzed can thus be started without the position of the thin layer plate (2, 3) needing to be changed for this purpose.
    Type: Application
    Filed: July 30, 2002
    Publication date: January 16, 2003
    Inventors: Rolf Guller, Seraphin Munch, Philippe Jablonski, Josef Schroer
  • Patent number: RE47124
    Abstract: Automated fluid handling system comprising a housing (20) and two or more fluid handling units (26) arranged as interchangeable modular components with an external fluidics section (30) and an internal non fluidics section (32), and wherein the housing (20) comprises a liquid handling panel (22) with two or more of component positions for receiving said interchangeable modular components (26) such that the external fluidics section (30) is separated from the non fluidics section (32) by the liquid handling panel (22).
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 13, 2018
    Assignee: GE Healthcare Bio-Science AB
    Inventors: Johan Blomberg, Mats Lundkvist