Abstract: A selectively removable closure for closing the open end of an NMR sample tube having an open end and a closed end of the invention includes a cylindrical proximal first and a distal second portion, both portions substantially congruent to a central axis, the second portion has a hollow bore extending therethrough, the hollow bore has: a first and a second distal section, a central section and a proximal section. The first distal section has an inside diameter sized to accept the outside diameter of a preselected size NMR sample tube substantially without an interference, the second distal section has an interference that ends into the central section with a ramp with an angle to the central axis greater than 70 degrees, the central section corresponds in a locked position on the NMR sample tube with a locking ring at least partially surrounding the NMR locking tube to form a secondary locking seal.

Abstract: A vial assembly may include a vial having a body to hold a liquid material, and a neck extending from the body. The neck may include a multi-use surface configured to permit access to the liquid material. The vial assembly may include a cap to be received by the neck and to cover the multi-use surface. The cap may include a base having a first major surface, and a second major surface opposite of the first major surface, arms extending from the second major surface, and a rupturable reservoir of disinfectant material carried by the base between the first major surface and the second major surface. One or more of the first major surface and the second major surface may be flexible so as to rupture the rupturable reservoir when the cap is received by the neck.

Abstract: Embodiments are directed to a removable cap with a conduction seal closure for sealing an opening of a container. The cap has a side wall and a top wall with an open access hole there-through. A flat upper portion surrounds the open access hole, which is sealed by the conduction seal. The conduction seal comprises a first polymer sealing layer, an aluminum foil layer on top of the first layer to heat seal the first layer to the cap, and a second polymer layer arranged on top of the aluminum foil layer for protection. The aluminum foil provides a formable shaping strength such that upon seal piercing, a permanent memory spread of the first and third layers is achieved. Removal of the cap does not damage the seal. Access to the container contents is achieved without probe contact to the as-pierced seal.

Abstract: Methods, apparatuses and systems for detecting tampering are disclosed. The methods, apparatuses and systems for detecting tampering can involve positioning at least a portion of one or more ingress/egress line having a first end and a second end in a clamping box configured to provide detection of tampering; and detecting tampering by observing the clamping box.

Abstract: A parenteral vial, stopper and cap assembly comprises a vial having a body defining an interior, and an opening leading to the interior. The assembly further comprises a stopper configured to sealingly engage the opening, a cap configured to cover the opening and the stopper. The stopper and the cap fit together to form an integral unit configured to cap the vial. The cap moves with respect to the vial between a partially engaged position that permits gas flow out from the vial interior, and a fully engaged position in which the stopper sealingly engages the opening.

Abstract: A deflation valve for use with a compression bag includes a base member and a lid member attached to the base member. The base member includes a deflation port and an inner cylindrical portion. The lid member includes a valve member and an outer cylindrical portion surrounding the valve member. The outer cylindrical portion includes an air passage portion and is arranged outwardly of the inner cylindrical portion. Suction of the deflation port causes an upward movement of the lid member to open the deflation port, imparting a negative pressure to the compression bag via the air passage portion and the deflation port. Stopping of the suction causes a downward movement of the lid member due to the negative pressure to close the deflation port with the valve member. The air passage portion serves as a finger hooking portion when opening the deflation port.

Abstract: A fluid container is provided that comprises a body portion configured to at least partially surround fluid. The container also includes a cap portion connected to and above the body portion at a frangible separation site surrounding an opening between the body portion and the cap portion. The cap portion is configured to separate from the body portion at the separation site to expose the opening when a substantially downwardly directed force is applied to a part of the cap portion at a certain radial distance from a longitudinal axis through the opening. The container can include a collar configured to be disposed at least around a part of the body portion. A portion of the collar can be configured to facilitate separation of the cap portion.

Abstract: A sealing device for a container comprising a circular cap designed to seal the neck of the container and a cover made from a synthetic material capable of covering both the neck and the cap fitted on the neck, the cover being provided with means for locking onto the neck, the cover being in one piece and comprising a skirt capable of radially surrounding a collar of the neck of the container, and an annular portion provided with a central opening allowing permanent access to the cap, and the skirt having at least two jamming areas for jamming the cap and, on the inner radial face thereof between the two jamming areas, a release area with a diameter strictly greater than the minimum unstressed diameter of the cap.

Abstract: There is provided a snap-on vial cap with a protective cover, which can be removed from a cap body by a constant removal force, and can hardly be attached to the cap body again, once being removed. A cap body 5 and a protective cover 6 are molded integrally by an insert molding method or a two-color-molding method, which generates moderate adhesive strength therebetween. An annular convex portion 12, 13 having a concave section 14 formed on the outer circumferential surface thereof is provided on the cap body 5, and an engagement portion 18 for engaging with the concave section 14 is provided on the protective cover 6, thereby enabling the protective cover 6 to be easily removed from the cap body 5 with good operativity while preventing the protective cover 6 from accidentally detaching. Alternatively, projections 23 provided on a top plate of the cap body 5 are engaged into a plug 4 to prevent the cap 1 from rotating.

Abstract: There is provided a snap-on vial cap with a protective cover, which can be removed from a cap body by a constant removal force, and can hardly be attached to the cap body again, once being removed. A cap body 5 and a protective cover 6 are molded integrally by an insert molding method or a two-color-molding method, which generates moderate adhesive strength therebetween. An annular convex portion 12, 13 having a concave section 14 formed on the outer circumferential surface thereof is provided on the cap body 5, and an engagement portion 18 for engaging with the concave section 14 is provided on the protective cover 6, thereby enabling the protective cover 6 to be easily removed from the cap body 5 with good operativity while preventing the protective cover 6 from accidentally detaching. Alternatively, projections 23 provided on a top plate of the cap body 5 are engaged into a plug 4 to prevent the cap 1 from rotating.

Abstract: A closure for a container, such as, for example, a wine bottle, is provided. In one embodiment, the closure includes an oxidant releasing agent that is adapted to release oxygen into an interior portion of the container according to a predefined desired profile. In another embodiment, the closure comprises a gas containing reservoir, a membrane and a barrier layer, the membrane allowing an at least partial exchange of gas between the inside of the reservoir and the inside of the container, and the barrier layer at least partially preventing exchange of gas between the outside of the closure and the inside of the reservoir.

Abstract: A cap for a cartridge having a bead at the distal end is disclosed. The cap comprises: a main body having a proximal end, a distal end, and a bore that receives the cartridge, the main body further comprising a first segment and a second segment; and a retention feature on the main body suitable for snapping under the bead of the cartridge for securing the cap to the cartridge.

Abstract: The present invention relates to a package, and more particularly to a package for sterile fluids, such as contrast media. More particularly the invention relates to a package comprising a container, a connecting plug and a cap. The package hence includes an integrated connection for easily transferring the content of the container of the package, e.g. to a syringe, a tube or a cartridge.

Abstract: A transfer device for pharmaceuticals comprising a housing which has an open bottom permitting insertion of a vial within the housing, a piercing member mounted within the housing and having an interior passageway formed therein, a connector for a syringe located on top of the housing, and a moveable member mounted within the housing, the moveable member being moveable from a first position preventing access to the piercing member and a second position permitting access to the piercing member when the vial is inserted in the housing.

Abstract: A locking device is disclosed for locking a cap on a container with a flange including a lid housing a bushing provided with lower inner notches supported under the flange and outer notches engaging with a groove in the lid to secure the bushing to the lid, the lid including a severable frangible zone, the bushing being formed by a ring extended by lugs intended to surround the cap and provided with at least one deformable and severable bridge provided opposite the lugs and capable of being elastically deformed radially to allow the forced insertion of the flange into the bushing and of being broken to allow the removal of the bushing relative to the flange followed by the removal of the cap from the container.

Abstract: A tamper-evident closure (10) for a container (20) is provided. The closure (10) comprises a first portion (25) including inner (35) and outer (45) parts, and a second portion (30). The outer part (45) is movable relative to the inner part (35) from a first position in which the outer part (45) is immediately adjacent the second portion (30) to a second position in which there is an empty unobstructed gap (G) therebetween. The inner (35) and outer (45) parts are adapted to become irreversibly locked in the second position so that the outer part (45) cannot be moved back to the first position to close the gap (G). A combination of such a closure (110) with an in-bore filament (100) connectable to a container (120) is also provided.

Abstract: Disclosed is a closure device for a container, which seals an opening (6) that opens at the top of a container (2) and has a rim (7) on its periphery. The closure device comprises a seal member (8) that is to cover the opening (6) on the top of the container (2), and a synthetic resin cap (9) that is to press the seal member (8) against the upper surface of the rim (7). The seal member (8) comprises a flange (10) to be mounted on the upper surface of the rim (7). The cap (9) comprises a top wall (15), a cylinder part (16), and a locking part (18). The top wall (15) is to be disposed above the flange (10). The cylinder part (16) hangs down from the outer circumference of the top wall (15). The locking part (18) is disposed on the inner surface of the cylinder part (16). After the cap (9) is pushed down, the locking part (18) locks at the under surface of the rim (7). The upper surface of the flange (10) has a compressible projection (29).

Abstract: A gasket for a compressed gas cylinder arranged to operate with a gas cylinder having a neck with a top surface around a gas outlet and a side surface extending downwardly from the top surface. The gasket may include an upper portion arranged for positioning on the top surface of the cylinder and for making a seal with the top surface, and a lower portion extending downwardly from the upper portion and around the side surface of the neck of the cylinder, such that the lower portion is arranged to make a seal with the side surface of the gas cylinder. Face and gland seals may be established by the gasket with an opening that receives the gasket and an associated cylinder neck.

Abstract: A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an a

Abstract: This device comprises an elastomer stopper (501) and a cap (502) suitable for covering both the neck (12) of a container and the stopper in position in this neck. The cap comprises a ring (503) provided with means (503G) for locking it to the neck and an operating member (504). The operating member (504) is fitted with at least one deformable part (506C) for transmitting a thrust load (f2) parallel to a central axis (X503) of the ring (503), between two portions (505, 506) of this member (504) or between an external material (301) and this member (504). The load transmitting part (506C) is deformable between a first configuration in which its length (L506) parallel to the central axis (X503) is a first value and a second configuration in which this parallel length is a second value that is less than the first value.

Abstract: The invention relates to a stopper device for a container having a neck with a ? axis. Said device comprises an elastomer stopper, a plastic cover that can cover both the neck and the stopper in place in the neck and comprises means for locking on the neck, and a cap adapted to the top of the cover by means of a central segment and provided with a peripheral supporting edge connected to the central segment by at least one connecting runout.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A closure for a container, e.g., a tube, for a sample, e.g., a biological sample. The closure comprises a cap having a first opening and a second opening, the first opening capable of communicating with the mouth of a container, the second opening sealed by an exterior seal, and intermediate the first opening and the exterior seal, an interior seal. The invention also provides an assembly comprising the closure of this invention and a container. The invention also provides a method for preparing the closure.

Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer (s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.

Abstract: A blinding cover completely surrounding the container comprises an axially movable and twistable lid that has means for gripping the sealing cap of the container and has a sampling point for a sampling needle. By axially moving and twisting the lid, the sealing cap is removed from the container, and the sampling point is positioned above the open container.

Abstract: Described here are unit dose containers, methods, and kits for treating asthma and other pulmonary conditions by nebulization. The unit doses of active agents are provided in a low volume formulation, which results in faster nebulization of the unit doses. The containers are also formed to minimize internal surface area so that effective re-dispersion of the active agents can be achieved while reducing adsorption to the walls of the containers.

Abstract: A pierceable cap maybe used for containing sample specimens during storage and transport. The pierceable cap may prevent unwanted escape of sample specimen before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the pierceable cap may allow passage of a tip of a transfer device though the pierceable cap. Multiple frangible layers maybe disposed across the access port. One or more extensions proximate to a lower frangible layer may rotate around one or more coupling regions during insertion of the transfer device. The movement of the one or more extensions may pierce the lower frangible layer to create airways and allow air to escape from a vessel at a reduced velocity. Upper frangible layers may prevent escape of materials from spaces intermediate between the lower frangible layer and the upper frangible layers.

Abstract: A pierceable cap may be used for containing sample specimens during storage and transport. The pierceable cap may prevent unwanted escape of sample specimen before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the pierceable cap may allow passage of a tip of a transfer device though the pierceable cap. A frangible layer may be disposed across the access port. One or more extensions proximate to the frangible layer may be coupled to the pierceable cap by coupling regions or other similar devices. The one or more extension may rotate around the one or more coupling regions during insertion of the transfer device. The movement of the one or more extensions may pierce the frangible layer to create airways and allow air to escape from a vessel at a reduced velocity.

Abstract: An apparatus for opening sealed packaging, including three parts, a pouring nozzle having a flange, a cylindrical cutting element and a screwcap. According to this invention, all three parts of the apparatus are produced in one piece as a semi-finished product. The teeth of the cutting element protrude into the pouring nozzle, while the screwcap is held on the flat edge of the cutting element. The three parts are connected to one another via predetermined breaking point bridges. This invention reduces the production costs and simplifies the assembly and the systems which are required for this purpose.

Abstract: A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.

Abstract: The closure device (500) comprises a stopper (501) made of elastomer and a cover (502) suitable for covering both the neck (12) of a container and stopper (501) in place in said neck (12). The cover (502) is made of plastics material and comprises a ring (503) and a drive member (504). The ring (503) may surround the stopper (501) and the neck (12) in the mounted configuration, the ring being provided with locking means (503G) for locking on the neck (12). The drive member (504) may be mounted on the ring (503) in arbitrary angular orientation about a central axis (X503) of the ring. The drive member is provided with an annular edge (505D) suitable for being engaged between an outer skirt (503A) of the ring (503) and at least one tab (503G) forming locking means and extending radially towards the central axis (X503) of the ring from the skirt (503A).

Abstract: Systems include one or more storage containers. A container may include one or more segments of a first ultra efficient insulation material shaped to define at least one substantially temperature-stabilized storage region, and an access region, including at least one region of the one or more segments of ultra efficient insulation material configured for at least one perforation by a perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a discrete quantity of material from the at least one storage region.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A hermetically sealed thermoplastic container is equipped with a unitary closure that includes a draining spike access aperture occluded by a removable, twist-off cap and an internal draining spike stabilizer situated in the neck portion of the container.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A closure system for a vial comprising: an elastic closure part to engage the mouth opening, a clamp part to hold the closure part in a closing relationship with the mouth opening, the clamp part defining an upper aperture through which a region of the upper surface of the closure part is exposed when the clamp part is engaged with the vial, a cover part to engage the clamp part to cover the exposed region, the cover part engaging with the closure part to provide two or more concentric ring-shaped seals, at least part of the cover part being removable from the vial to allow access to the closure.

Abstract: A closure system for a pharmaceutical vial, comprising an elastomer closure part, a clamp part which holds the closure part in engagement with the mouth of the vial, and a cover part which engages with the clamp part. The interior of the closure part is profiled to minimize retention of residual liquid therein.

Abstract: The invention relates to a plastic closing device comprising a bottom part, a closing cap, and a cutting ring which is mounted inside the neck of the bottom part so as to be helically movable. A driving cam (16) which is axially disposed in the closing cap acts upon the non-continuously circular cutting ring when the closing cap is unscrewed such that the cutting ring perforates and cuts through the receptacle in a helical cutting movement. The cutting ring forms a ventilating concavity (6) which cooperates with the driving cam (16). The non-circular cutting ring, the bottom side of which is provided with a sharp cutting edge extending at an obtuse angle relative to the bottom edge of said ring, performs a helical cutting movement similar to an advancing knife when the closing cap is unscrewed such that the receptacle wall is easily cut by applying a minimum amount of force because a new sharp point constantly attacks the packaging material, thus preventing shredding.

Abstract: A container cap locking a plug member to a mouth by a locking member and capable of being removed from the mouth together with the plug member by repositioning a holder member. The locking member is covered on the container mouth so as to hold the plug and the holder member is fitted to the outer peripheral sides of a plurality of locking pieces of the locking member. In each locking piece, an upper side part is connected to a lower side part through a thin-walled bending part. The upper side part is locked to the rubber plug from the lower side with the holder member on the outer peripheral side thereof. The lower side part is locked to the container mouth from the lower side by the holder member. Locking projected parts prevent the lower end of the holder member from coming out of the upper side part.

Abstract: A kit for preparing a cancer cell detection sample which is highly safe, simple, and high in precision, and can detect a cancer cell quantitatively, and a kit for cancer cell detection using the same, as well as a method for diagnosing cancer using those kits, and a method for preparing a sample for cancer cell detection are provided. A kit for preparing a detection sample for detecting a cancer cell of the present invention, comprising a test container having an opening for receiving a biological sample collected from a subject, and a reagent inclusion part for accommodating a reagent containing a virus, a seal part for sealing the reagent inclusion part of the test container, a cap for closing the opening, and an opener for breaking the seal part.

Abstract: The invention relates to a closure for a liquid container, comprising a plug manufactured from at least partially flexible material with a recess which is arranged at least substantially in axial direction in the plug and which is accessible on at least one side, and an operating member protruding outside the plug and displaceable in the recess such that a force exerted by the operating member on the recess in the plug can be modified by displacing the operating member. The invention also relates to methods for placing such a closure into a liquid container and removing thereof from a liquid container.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: Based on an objective of configuring and refining a closure in such a way that a stopper accommodated in the cap is secured therein so that it cannot fall out and so that it can be cleaned or sterilized without any problem together with the container, with the substance contained therein and with the cap, a closure for a container, includes a cap, the cap forming an interior space into which a stopper can be inserted in the axial direction in order to seal the container, and the cap having holding members that protrude into the interior space, is characterized in that the holding members latch the stopper in such a way that the latter is affixed in a prescribed position in the axial direction.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.

Abstract: An apparatus for opening sealed packaging, including three parts, a pouring nozzle having a flange, a cylindrical cutting element and a screwcap. According to this invention, all three parts of the apparatus are produced in one piece as a semi-finished product. The teeth of the cutting element protrude into the pouring nozzle, while the screwcap is held on the flat edge of the cutting element. The three parts are connected to one another via predetermined breaking point bridges. This invention reduces the production costs and simplifies the assembly and the systems which are required for this purpose.

Abstract: A connector for use in connecting a container of liquid nutrients to an enteral feeding tube to supply the liquid nutrients to a patient includes an integrally formed spike projecting into a cavity defined by an interior surface of a body of the connector. An air passage in communication with the cavity extends through the spike to outside the connector. A filter is secured to the end of the passage outside the connector. The body of the connector is free of structure that both defines any portion of the liquid passage and is formed for penetrating the puncturable seal of the container.

Abstract: This invention container comprises a container shell comprising a body portion, adjoining cap portion and enclosed stopper, and an engineered separation site to facilitate separation of body and cap. The stopper has a raised nipple on the stopper, positioned such that a portion of the stopper is enclosed within the body portion and a portion of the stopper is enclosed within the cap portion. When the cap portion is removed from the body portion, a portion of the nipple therefore extends out of the body portion, allowing easy access to the stopper for cleaning or contents removal. In addition, there is an engineered separation site which includes a partial attenuation of the thickness of part of the container wall. Raised gussets are provided to enhance the cooperation between the instant invention and various needle-free connectors known in the art.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.