Including Vitrification Or Firing Patents (Class 264/43)
  • Patent number: 6071535
    Abstract: The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: June 6, 2000
    Assignee: Collaborative Laboratories, Inc.
    Inventors: James A. Hayward, David C. Watkins, Duncan T. Aust
  • Patent number: 6060080
    Abstract: A liposomal aqueous dispersion and method of making the liposomal aqueous dispersion is useful for encapsulation of drugs. The liposomal aqueous dispersion comprises: an aqueous suspension medium; multilamellar liposomes comprising an anionic phospholipid and cholesterol as essential components; neutral phospholipid in a mole ratio of 0 to 40% based on the total amount of said multilamellar liposomes; and a cation moiety-containing water-soluble drug, wherein the electrolyte concentration of said aqueous suspension medium is not more than 40 mM.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: May 9, 2000
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kikuchi, Kiyoto Yachi, Sadao Hirota
  • Patent number: 6051250
    Abstract: The invention relates to a process for stabilization of vesicles formed from a lipid-phase membrane containing at least one ionic and/or nonionic amphiphilic lipid encapsulating an aqueous phase, in the form of a dispersion in an aqueous phase, by addition of at least one stabilizing agent to the aqueous dispersion phase, in which the stabilizing agent (s) is/are chosen from the group composed of glycerol alginates, propylene glycol alginates, gellan gum and wellan gum. The invention also relates to a composition for topical application containing vesicles stabilized by the said process.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: April 18, 2000
    Assignee: L'Oreal
    Inventors: Alain Ribier, Jean-Thierry Simonnet
  • Patent number: 6051251
    Abstract: A method for loading a therapeutic compound having a cis diol moiety into pre-formed liposomes is described. The method includes adding to a suspension of liposomes (i) the compound to be loaded into the liposomes and (ii) a boronic acid compound, thereby achieving accumulation of the compound within the liposomes.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: April 18, 2000
    Assignee: Alza Corporation
    Inventors: Samuel Zalipsky, Paul S. Uster, George Z. Zhu
  • Patent number: 6048546
    Abstract: A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: April 11, 2000
    Assignee: Sandia Corporation
    Inventors: Darryl Y. Sasaki, Douglas A. Loy, Stacey A. Yamanaka
  • Patent number: 6048551
    Abstract: A controlled release delivery system includes a functional gene vector in a biodegradable polymeric microsphere encapsulating the vector. The present invention further provides a method of making a controlled release delivery system by encapsulating the functional gene vector in a biologically degradable polymeric microsphere.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: April 11, 2000
    Inventors: John M. Hilfinger, Beverly L. Davidson, Steven J. Beer, John R. Crison, Gordon L. Amidon
  • Patent number: 6045824
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is usefuil for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: April 4, 2000
    Assignee: SkyePharma Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdandi
  • Patent number: 6045835
    Abstract: A method of encapsulating an amphiphilic flavor or fragrance compound into a microcapsule having a hydrogel shell and an oil core. The flavor or fragrance compound is transported into and solubilized in the core by partition coefficient equilibrium using water in the capsule wall to transport the compound into the core. Microcapsules made by the method of the invention may have a wall thickness and contain a high concentration of the flavor or fragrance compound that has not previously been feasible.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: April 4, 2000
    Assignee: Givaudan Roure (International) SA
    Inventors: Jon C. Soper, Young D. Kim, Margaret T. Thomas
  • Patent number: 6042763
    Abstract: This invention relates to a method for treating various kinds of drain water and waste liquid which treatment now becomes a problem, for example, drain water and waste liquid containing hardly removable phosphorus and nitrogen, waste liquid containing organochlorine compounds such as tetrachloroethylene, etc., excretive drain water from a piggery containing organonitrogen compounds at a high level, waste liquid containing heavy metals such as lead, hexavalent chromium, cadmium and the like, drain water from dairy product plants, fishery processing plates, slaughterhouses, etc. which contains water soluble protein at a high level, drain water from pulp plants, photo developing waste liquid, car wash drain water containing a mixture of car polishing wax and detergent and the like by the use of porous ceramics provided with amorphous pore surfaces.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: March 28, 2000
    Inventor: Shun'ichi Kumaoka
  • Patent number: 6039901
    Abstract: Enzymatic cross-linking of protein-encapsulated oil particles by complex coacervation. A complex coacervate of oil particles, each encapsulated in a protein shell, is stabilized by gelling the protein shell and is subsequently enzymatically cross-linked to form thermostable capsules of about 100-300 microns. The preferred enzyme is transglutaminase, and the reaction is performed at pH 7 to achieve the optimal cross-linking rate. The transglutaminase-catalyzed cross-linking reaction takes place with the complex coacervate maintained at a temperature in the range of about 5.degree. C.-10.degree. C. to maintain the structural stability of the complex coacervate.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: March 21, 2000
    Assignee: Givaudan Roure Flavors Corporation
    Inventors: Jon C. Soper, M. Teresa Thomas
  • Patent number: 6033708
    Abstract: The present invention relates to a composition and method of producing noggregating, filterable dispersion of liposome encapsulated agent or therapeutic of interest, specifically hemoglobin. A key step in the method of the present invention is the addition of a passivating protein prior to hydration of the liposomes with the agent of interest. The resulting dispersion is composed of unilamellar vesicles having a diameter of less than or equal to 0.2 microns.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: March 7, 2000
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Victoria Kwasiborski, Richard O. Cliff, Alan S. Rudolph
  • Patent number: 6022500
    Abstract: A process is described for the enzyme catalyzed synthesis of polymeric microspheres from monomers such as ethylphenol, naphthols and hydroxypyrenes in reverse micelles in the presence of a detergent. Polymeric microspheres synthesized are porous with nonuniform densities. Polymers prepared from naphthols and hydroxypyrenes are fluorescent with electroluminescent properties. A number of materials such as enzymes, drugs and inorganic materials such as iron oxide and cadmium sulfide are encapsulated in the hollow polymeric microspheres synthesized. These encapsulations are carried out during or after the syntheses of the polymeric microspheres. Functional properties of the encapsulated materials such as enzyme, magnetic and nonlinear optical properties are demonstrated in the polymeric composites.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: February 8, 2000
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Vijay T John, Gary L McPherson, Joseph A Akkara, David L Kaplan
  • Patent number: 6022525
    Abstract: Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules.Suitable wall-forming materials include proteins such as albumin and gelatin.The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: February 8, 2000
    Assignee: Quadrant Healthcare (UK) Limited
    Inventors: Andrew D. Sutton, Richard A. Johnson, Peter J. Senior, David Heath
  • Patent number: 6020200
    Abstract: The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods for their preparation. The encapsulated compositions may comprise the crosslinked polymer matrix layer as an inner layer, an outer layer, or an intermediate layer of an overall encapsulated composition. The compositions will generally also comprise a biological material, e.g., cells, proteins, and the like, encapsulated within the composition. The compositions and methods of the invention are useful in a variety of applications, including cell culturing and transplant therapy.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: February 1, 2000
    Assignee: Metabolex, Inc.
    Inventor: Karl C. Enevold
  • Patent number: 6007839
    Abstract: Described herein are methods of preparing liposome-containing pharmaceutical compositions, the liposomes containing headgroup-derivatized lipids and etherlipids having the formula: ##STR1## Such compositions are useful in the treatment of a variety of conditions, including various cancers and inflammatory disorders.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: December 28, 1999
    Assignee: The Liposome Company, Inc.
    Inventors: Eric Mayhew, Andrew S. Janoff, Imran Ahmad, Suresh K. Bhatia
  • Patent number: 6007838
    Abstract: A process for making a liposome preparation comprised of liposomes that contain an encapsulated material is disclosed. The process comprises (A) providing a plurality of portions of a lipid or liposome formulation; (B) hydrating each of the plurality of portions with a solution comprising a material to be encapsulated; and (C) combining each of the plurality of portions to form a single liposome preparation. The liposome preparations can be used for drug delivery or as vaccines.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 28, 1999
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Carl R. Alving, Roberta R. Owens, Nabila M. Wassef
  • Patent number: 6004534
    Abstract: The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type in order to optimize the immune response to the encapsulated antigen or the efficacy of the encapsulated drug.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: December 21, 1999
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, Hongming Chen
  • Patent number: 5993851
    Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: November 30, 1999
    Assignee: PharmaDerm Laboratories, Ltd.
    Inventor: Marianna Foldvari
  • Patent number: 5993852
    Abstract: A composition for transdermal administration of an immunogen is described. The immunogen is entrapped in lipid vesicles having a oil-in-water emulsion in the central core compartment. The vesicles are administered transdermally to elicit an immune response in a subject.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: November 30, 1999
    Assignee: PharmaDerm Laboratories LTD.
    Inventors: Marianna Foldvari, Maria Baca-Estrada
  • Patent number: 5993850
    Abstract: Disclosed are multivesicular liposomes (MVL's) containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a controlled and variable release rate of the biologically active substance. The process involves encapsulating at least one biologically active substance and optionally an osmotic spacer in a first aqueous component encapsulated within the liposomes. The rate of release of the active substance into the surrounding environment in which the liposomes are introduced can be decreased by increasing the osmolarity of the first aqueous component or increased by decreasing the osmolarity.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: November 30, 1999
    Assignee: SkyePharma Inc.
    Inventors: Mantripragada B. Sankaram, Sinil Kim
  • Patent number: 5989467
    Abstract: The present invention is embodied in a ceramic foam made by mixing a liquid pre-ceramic resin and a liquid phenolic resin, allowing the resultant mixture to chemically foam, curing the mixture for a time and at a temperature sufficiently to convert the mixture to a polymeric foam, and then heating the resultant polymeric foam for a time and at a temperature sufficient to break-down polymers of the polymeric foam and convert the polymeric foam to a ceramic foam. The ceramic foam of the present invention contains residual decomposed components of the liquid phenolic resin and/or liquid pre-ceramic resin.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: November 23, 1999
    Assignee: Northrop Grumman Corporation
    Inventors: David Eric Daws, Nicholas T. Castellucci, Harry Wellington Carpenter, Mary Wagner Colby
  • Patent number: 5985247
    Abstract: An imaging agent for ultrasound to be administered into a vein is provided. More specifically, an imaging agent for ultrasound containing microbubbles, which has a long-life and is stable within a human body even after is has passed through a lung, and a method for producing the same, are provided.A method for producing an imaging agent for ultrasound comprises a mixing step wherein a mixture of water, Sodium Stearate, Saponin and CaCl.sub.2 and gas are mixed by a homogenizer for forming bubbles, and a separation step wherein bubbles having a desired size are separated according to their buoyancy after the mixing step. The mixing step further includes two stages, i.e., a low speed mixing stage and a high speed mixing stage. In the low speed mixing stage, a shaft of the homogenizer is immersed into a solution containing a preset amount of Sodium Stearate, Saponin, and CaCl.sub.2, which is mixed at a low rotation speed for a given period of time and is then left for a given period.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: November 16, 1999
    Assignee: Gakko Houjin Toin Gakuen
    Inventor: Kawan Soetanto
  • Patent number: 5980937
    Abstract: The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: November 9, 1999
    Assignee: Bracco Research S.A.
    Inventors: Herve Tournier, Michel Schneider, Christian Guillot
  • Patent number: 5981501
    Abstract: Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. The particles are typically 65-85 nm, fully encapsulate the plasmid and are serum-stable.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 9, 1999
    Assignee: Inex Pharmaceuticals Corp.
    Inventors: Jeffery J. Wheeler, Michael Hope, Pieter R. Cullis, Marcel B. Bally
  • Patent number: 5976454
    Abstract: A process for producing open-celled, inorganic sintered foam products which comprises:a. converting slip material comprising sinterable inorganic powder, a fluid, vaporizable material which makes this slip material capable of flow and, if desired, a material forming blowing gas into a foamed product in a foaming step with liberation of the blowing gas,b. subjecting this foamed product to a treatment which essentially makes the slip material incapable of flow and forms an open-pored intermediate body, with the steps a. and b. being able to proceed essentially simultaneously,c. removing material remaining from the fluid material and any further material from the intermediate body to form a green foam body, andd. sintering the green foam body to form the open-celled, inorganic sintered foam product.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: November 2, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Josef Sterzel, Michael Hesse, Andreas Kleinke
  • Patent number: 5976405
    Abstract: Disclosed are uniformly sized domains of liquid crystals, a method for forming the domains, and their performance in polymer dispersed liquid crystal displays. The method provides the ability to form discrete domains of liquid crystal surrounded by a polymer shell, also known as polymer encased liquid crystals, or PELCs. Further, the method provides for the ability to make PELCs that have uniformly sized particles. Displays made comprising uniformly sized PELCs demonstrate markedly improved electro-optical performance over displays made by conventional polymer dispersed liquid crystal processes.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: November 2, 1999
    Assignee: Rohm and Haas Company
    Inventors: Richard Roy Clikeman, Morris Christopher Wills, Peter Reeves Sperry, Martin Vogel, Jiun-Chen Wu, Willie Lau
  • Patent number: 5968426
    Abstract: The present invention relates to a method for producing a porous silicon nitride sintered body having high strength and low thermal conductivity, which comprises of adding more than 10 volume % of rodlike beta-silicon nitride single crystals with a larger mean diameter than that of a silicon nitride raw powder into a mixture comprising the silicon nitride raw powder and a sintering additive, preparing a formed body with rodlike beta-silicon nitride single crystals oriented parallel to the casting plane according to a forming technique such as sheet casting and extrusion forming, sintering said formed body to develop elongated silicon nitride grains from the added rodlike beta-silicon nitride single crystals as nuclei and obtain the sintered body with the elongated grains being dispersed in a complicated state.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: October 19, 1999
    Assignees: Japan as represented by Director General of Agency of Industrial Science and Technology, Fine Ceramics Research Association
    Inventors: Kiyoshi Hirao, Manuel E. Brito, Motohiro Toriyama, Syuzo Kanzaki, Hisayuki Imamura, Takene Hirai, Yasuhiro Shigegaki
  • Patent number: 5965109
    Abstract: The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: October 12, 1999
    Assignee: Molecular Biosystems, Inc.
    Inventor: Rolf Lohrmann
  • Patent number: 5965158
    Abstract: A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 12, 1999
    Assignees: The University of Texas System & Board of Regents, Aronex Pharmaceuticals, Inc.
    Inventors: Robert P. Link, Reeta Mehta, Gabriel Lopez-Berestein
  • Patent number: 5965434
    Abstract: The present invention provides amphipathic lipid compounds comprising a hydrophilic, catonic, pH-sensitive moiety, the positive charge of which moiety increases as pH decreases over the pH range of 8.0 to 4.5. Vesicular delivery systems comprising such amphipathic compounds and the use of those systems for delivering biologically active substances to cells are also provided.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: October 12, 1999
    Inventors: Jon A. Wolff, Vladimir Budker, Vladimir Gurevich
  • Patent number: 5965070
    Abstract: A process for fractionating agaroid compositions by dissolving the agaroid in a glycol, precipitating a first fraction by cooling and precipitating a second fraction by incorporating a nonsolvent to form two fractions substantially more soluble in water than the initial agaroid. Optionally the solubility of either fraction can be converted to conventional solubilities.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 12, 1999
    Assignee: FMC Corporation
    Inventor: Richard B. Provonchee
  • Patent number: 5958449
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipid and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided. A method is also provide for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: September 28, 1999
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Evan M. Hersch, Eskild A. Petersen, Richard T. Proffitt, Kevin R. Bracken, Su-Ming Chiang
  • Patent number: 5948441
    Abstract: Tangential flow filtration is used in the size separation of particles, such as liposomes and lipid particles. These particles may be passed through a tangential flow filtration device of any pore size desired. Tangential flow filter systems of various pore sizes may be used sequentially to obtain particles such as lipid particles or liposomes having a defined size range.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: September 7, 1999
    Assignee: The Liposome Company, Inc.
    Inventors: Robert P. Lenk, Anthony G. Durning, Robert J. Klimchak, Joel Portnoff, Michelle L. Tomsho
  • Patent number: 5945122
    Abstract: A liposome composition containing an entrapped cisplatin compound is described. The liposomes have a surface coating of hydrophilic polymer chains on inner and outer surfaces and an entrapped cisplatin compound. The compound is entrapped with substantially greater retention in the liposomes, when compared to liposomes lacking the polymer coating. A method of preparing the composition is also described.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: August 31, 1999
    Assignee: Sequus Pharmaceuticals, Inc.
    Inventors: Robert M. Abra, Karen Reis
  • Patent number: 5938992
    Abstract: A production method of a honeycomb structure is provided. The production method of a thin wall cordierite honeycomb structure having cordierite as the main component of the crystalline phase includes: adding a forming auxiliary agent to a cordierite material to obtain a mixture, kneading the mixture to obtain a material batch, forming the material batch by extrusion to form a honycomb compact, drying the honeycomb compact to obtain a dried body, and firing the dried body. The cordierite material batch contains 65% by weight or more flat plate-like cordierite raw material including crystal water made from talc, kaolin and aluminum hydroxide with the BET specific surface areas for the cordierite raw materials being 7 to 18 m.sup.2 /g of talc, 14 to 22 m.sup.2 /g of kaolin and 6 to 18 m.sup.2 /g of aluminum hydroxide.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: August 17, 1999
    Assignee: NGK Insulators, Ltd.
    Inventors: Toshiyuki Hamanaka, Wataru Kotani
  • Patent number: 5928583
    Abstract: Process for making graded porosity ceramics. A process for making graded porosity ceramics is described which includes the steps of placing a chosen amount of ceramic powder into a mold, compacting the ceramic powder into a green body, applying at least one sintering aid precursor to at least one chosen surface of the green body, allowing the at least one sintering aid precursor to penetrate the at least one surface within a chosen volume of the green body, heating the green body, whereby the sintering precursor generates a sintering aid, and hot pressing and sintering the heated body at a temperature whereby the green body is transformed into the sintered ceramic object.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: July 27, 1999
    Assignee: The Reagents of the University of California
    Inventors: Kenneth J. McClellan, John J. Petrovic, Ivar E. Reimanis
  • Patent number: 5925309
    Abstract: A method of manufacturing ceramic filter media for water filters involves the steps of mixing a plurality of raw ceramic materials and a plurality of extrusion-aid materials to form a mixture of constituent materials, extruding the constituent materials to form tubular filter media, drying the tubular filter media, and firing the tubular filter media to create ceramic tubular filter media. The step of drying the tubular filter media preferably comprises placing the tubular filter media on top of rotating rollers which dries the tubular filter media evenly and preserves the desired characteristics of the tubular filter media.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: July 20, 1999
    Assignee: Mountain Safety Research
    Inventors: Osgood J. Whittemore, Chris J. Adams, Daniel J. Vorhis
  • Patent number: 5925464
    Abstract: Microencapsulated compositions, useful, for example, as pesticidal formulations, were prepared a process in which the microcapsules containing the encapsulated material are formed in an interfacial polycondensation reaction carried out in the presence of one polyvinylalcohol, a different polyvinylalcohol is added, and the resulting mixture is spray dried.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: July 20, 1999
    Assignee: Dow AgroSciences LLC
    Inventors: Patrick Joseph Mulqueen, Geoff Smith, Steven D. Lubetkin
  • Patent number: 5922652
    Abstract: Gelatin capsules containing oil field chemicals, preferably weighted with a heavy metal compound, are made more stable under certain conditions by the incorporation of a strong chelating agent. The microcapsules can provide an extended treatment period since many materials that would damage the microcapsules are controlled by the chelating agent.
    Type: Grant
    Filed: May 5, 1992
    Date of Patent: July 13, 1999
    Inventors: Thomas Charles Kowalski, Robert Wayne Pike
  • Patent number: 5919407
    Abstract: A microencapsulated adhesive and a method for producing that microencapsulated adhesive are disclosed. The adhesive is produced from a solvent-based adhesive composition such as a styrene butadiene rubber composition or an acrylic. The solvent-based adhesive composition may be encapsulated by interfacial polymerization, gelatin/gum arabic coacervation or melamine/formaldehyde encapsulation. The solvent is removed from the microcapsules by heating or reduced pressure to form an adhesive that is non-tacky, but becomes tacky upon application of external forces, such as shearing. The microencapsulated adhesive composition may be used, among other applications, as an adhesive for stamps or envelopes.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: July 6, 1999
    Assignee: Moore Business Forms, Inc.
    Inventor: Hung Ya Chao
  • Patent number: 5916790
    Abstract: The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods for their preparation. The encapsulated compositions may comprise the crosslinked polymer matrix layer as an inner layer, an outer layer, or an intermediate layer of an overall encapsulated composition. The compositions will generally also comprise a biological material, e.g., cells, proteins, and the like, encapsulated within the composition. The compositions and methods of the invention are useful in a variety of applications, including cell culturing and transplant therapy.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: June 29, 1999
    Assignee: Metabolex, Inc.
    Inventor: Karl C. Enevold
  • Patent number: 5916680
    Abstract: A thermo-responsive microcapsule containing a diazo compound or an electron donative dye precursor, wherein the capsule wall of the microcapsule is composed of at least one polymer obtained by polymerization of an isocyanate compound containing an adduct of (A) a compound having one active hydrogen in the molecule and having an average molecular weight from 500 to 20000 and (B) a multifunctional isocyanate having two or more isocyanate groups in the molecule, and a heat-sensitive recording material and a multicolor heat-sensitive recording material comprising a heat-sensitive recording layer containing the microcapsule are disclosed.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: June 29, 1999
    Assignee: Fuji Photo Film Co., Ltd
    Inventors: Yuichi Wakata, Kimio Ichikawa
  • Patent number: 5910462
    Abstract: Porous zirconia or zirconium-containing particles, methods of making such particles and methods of using such particles including modifications to the surface of the particles are described. The method comprises heating zirconia particles to provide a substantially homogeneously liquid melt, quenching the particles of melt to effect spinodal decomposition to provide quench particles of a silica rich phase and a zirconia rich phase, annealing the quenched particles to provide non porous solid particles of zirconia and silica and, leaching the silica from these particles to produce porous solid zirconia particles comprising a three dimensionally substantially continuous inter penetrating network of interconnected pores.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: June 8, 1999
    Inventors: Mary Susan Jean Gani, Hans-Jurgen Wirth, Marie Isabel Aguilar, Milton Thomas William Hearn, Donald George Vanselow, Philip Hong Ning Cheang, Kjell-Ove Eriksson
  • Patent number: 5895661
    Abstract: The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: April 20, 1999
    Assignee: Bracco Research S.A.
    Inventors: Herve Tournier, Michel Schneider, Christian Guillot
  • Patent number: 5888538
    Abstract: Apparatus and method for the production of seamless capsules comprising a shell material encapsulating a center-filled core material in which a heated carrier liquid or air is cooled by a heat exchanger.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 30, 1999
    Assignee: Warner-Lambert Company
    Inventors: Jesse John Kiefer, Blake Henderson Glenn
  • Patent number: 5874126
    Abstract: The process for making a porous mass containing dense aggregates or granu includes the steps of mixing powder with more than 10% by weight of a binder to form agglomerated powder, heating the agglomerated powder to remove the binder and to grow crystallites in the powder to an average diameter exceeding 5 microns to form a porous mass containing the dense aggregates, and cooling the porous mass. The porous mass is broken up, if it is cohesive, into the aggregates containing the crystallites and the aggregates can be used to make an article, such as a transducer. The transducer is essentially a thick film and its thickness is that of the ceramic aggregates of granules. The electrodes connect to the top and to the bottom of the aggragates. As a result, the transducer material operates in the 1-3 mode.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: February 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Manfred Kahn, Mark Chase
  • Patent number: 5874105
    Abstract: A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: February 23, 1999
    Assignee: Collaborative Laboratories, Inc.
    Inventors: David C. Watkins, Thomas J. Vichroski, James A. Hayward
  • Patent number: 5871677
    Abstract: In order to manufacture a light, open-pored, mineral insulating board with a gross density below 130 kg/m.sup.3 the following steps are employed:a) producing a water-solids suspension by intensive mixing of the following raw materials in an intensive mixer with a rotating mix container and a mixer mechanism rotating at a higher speed, using water and, in each case referred to the total content of solids, 40 to 48 M % (mass percent) quartz flour with a specific surface area according to BET of at least 2.5 m.sup.2 /g, 15 to 20 M % slaked lime with a specific surface area of at least 15 m.sup.2 /g, 25 to 35 M % cement, 0.3 to 0.5 M % hydrophobic medium, the rest additives, wherein the ratio of cement to slaked lime amounts to 1.5 to 2.3:1, the binder proportion lies in the range from 45 to 52 M % and the suspension has a water/solids factor (without foam) from 0.7 to 1.2,b) preparing a foam from water, air and a pore former, with a gross density from 40 to 50 kg/m.sup.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: February 16, 1999
    Assignee: Hebel Aktiengesellschaft
    Inventors: Silke Falke, Emmo Frey, Frithjof Koerdt
  • Patent number: 5871722
    Abstract: Ionic compositions comprise an active ingredient absorbed within a network of internal pores defined by a plurality of polymeric particles. The particles are preferably crosslinked polymeric beads having a diameter in the range from about 5 to 100 microns and a surface charge density from about 0.1 to 10 meq/qm hydrogen ion capacity. The active ingredients are released from the ionic polymer beads over time when orally administered, applied to a keratinic material, typically human skin or hair or otherwise delivered to a target environment. The use of a cationic charge promotes adhesion of the beads to the keratinic material.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: February 16, 1999
    Assignee: Advanced Polymer Systems, Inc.
    Inventors: Sergio Nacht, Richard Won, Martin A. Katz, Tai Cheng, Christine J.Y. Liau, Robert P. Eury, Michael Froix
  • Patent number: 5866155
    Abstract: Methods for producing matrices useful in bone graft onlay and inlay procedures are provided. Compositions prepared by these methods are also provided.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: February 2, 1999
    Assignee: Allegheny Health, Education and Research Foundation
    Inventors: Cato Laurencin, Mark Borden