Formation Of Solid Particulate Material Directly From Molten Or Liquid Mass (e.g., Liquid Comminuting) Patents (Class 264/5)
  • Publication number: 20110274892
    Abstract: A laminate film including at least one bio-based polyolefin layer including at least 53 pMC of radiocarbon (14C) content is disclosed. The laminate film may include additional layers such as a second bio-based polyolefin resin-containing layer of at least 53 pMC radiocarbon content, and a metal layer.
    Type: Application
    Filed: May 6, 2011
    Publication date: November 10, 2011
    Applicant: TORAY PLASTICS (AMERICA), INC.
    Inventors: Keunsuk P. Chang, Michael F. Brandmeier
  • Publication number: 20110272836
    Abstract: Vessels, including non-symmetric vessels for mixing fluids, are disclosed. In one aspect, the vessel is one that has a non-rotationally-symmetric interior surface. For example, the vessel may have an oblique frustoconical shape. At least a portion of the mixing vessel may have horizontal cross-sections having varying area, in some embodiments. The vessel may be formed from any suitable material, e.g., glass, plastic, or stainless steel. Such vessels may be used, according to certain embodiments, to create single, double or other multiple emulsions, for example, by exposing liquids or fluids contained therein to relatively high shear rates. In some cases, the vessel may be designed to be pharmaceutical-grade and/or meet ASME Bioprocessing Equipment (ASME-BPE) standards. For instance, the vessel may be used under conditions where the vessel is sterile, and/or the vessel may have a polished internal surface.
    Type: Application
    Filed: April 12, 2011
    Publication date: November 10, 2011
    Applicant: Selecta Biosciences, Inc.
    Inventors: MARK J. KEEGAN, Donna L. Kessel
  • Publication number: 20110260348
    Abstract: A method of producing dried cellulose nanofibrils includes atomizing an aqueous suspension of cellulose nanofibrils and introducing the atomized aqueous suspension into a drying chamber of a drying apparatus. The aqueous suspension is then dried, thereby forming substantially non-agglomerated dried cellulose nanofibrils.
    Type: Application
    Filed: April 27, 2011
    Publication date: October 27, 2011
    Applicant: UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
    Inventors: Douglas J. Gardner, Yousoo Han, Yucheng Peng
  • Publication number: 20110241236
    Abstract: A method of forming granules, the method including forming a suspension of a nanopowder such as a nano zirconia powder containing yttria. The powder is formed from a suspension, and freon is added directly to the suspension as an additive. The suspension is then granulated by spray freeze drying, and the freon subsequently removed by heat treatment. The voids left by the vacated freon provide meso, micro and macro flaws or structural defects in the granules.
    Type: Application
    Filed: October 14, 2009
    Publication date: October 6, 2011
    Inventors: Annapoorani Ketharam, Balasubramaniam Vaidhyanathan, Bala Praveen Chakkravarthy Raghupathy, Jonathan Graham Peel Binner
  • Publication number: 20110241235
    Abstract: The present invention relates to a process of making spray-dried detergent particles comprising the steps: (a) contacting magnesium sulphate with sodium salt of ethylenediamine disuccinic acid to form a premix comprising magnesium salt of ethylenediamine disuccinic acid; (b) contacting said premix with an aqueous slurry comprising detersive surfactant, sodium silicate, and optionally polymer; and (c) spray drying said aqueous slurry to form said spray-dried detergent particles.
    Type: Application
    Filed: September 23, 2010
    Publication date: October 6, 2011
    Inventors: Rohan Govind Murkunde, Paul Andrzej Luksza, Carlos Arca Quinones
  • Patent number: 8025824
    Abstract: To provide a process for producing high-purity highly oxidized refractory particles easily with good productivity by treating a spent refractory containing ZrO2 and Al2O3 to reduce components other than ZrO2 and Al2O3 to levels unproblematic for practical use as raw material for electrofused refractories and to increase the content of the ZrO2 and/or Al2O3 component. A process for producing refractory particles, which comprises introducing to and melting in a melting furnace both a spent refractory which contains, by mass % as chemical components, from 75 to 97% of ZrO2 and/or Al2O3, from 2 to 25% of SiO2, from 0.4 to 7% in total of Na2O, K2O and Li2O(Na2O+K2O+Li2O), at most 2% of CaO and at most 2% of MgO, and carbon particles in an amount of from 1 to 8% by outer mass percentage based on the spent refractory, and after the melting, tapping the melt while blowing compressed air against the melt to form refractory particles having the content of ZrO2 and/or Al2O3 increased.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: September 27, 2011
    Assignee: AGC Ceramics Co., Ltd.
    Inventor: Yukihiro Ushimaru
  • Patent number: 8012385
    Abstract: The present invention relates to a liquid crystal display (LCD) device, and more particularly, to a method of fabricating a color filter for an LCD device. A method of fabricating a color filter uses a mold (PDMS mold) having a plurality of grooves. Particularly, the mold (PDMS mold) is attached to a substrate such that the plurality of grooves face into the substrate. When a color resin is dropped into a side opening of each groove, the color resin is injected into each groove of the mold (PDMS mold) by a capillary force. After the mold (PDMS mold) having the injected color resin is cured, the mold (PDMS mold) is detached from the substrate and a color filter pattern is formed at a desired position.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: September 6, 2011
    Assignee: LG Display Co., Ltd.
    Inventor: Jin-Ook Kim
  • Patent number: 7993557
    Abstract: The invention relates to a method and device for the direct production of polyester granulate from a highly viscous polyester melt with a polymerization degree of 132 to 165, as well as the granulates formed thereform. In the method, the highly viscous polyester melt is subjected to a pre-drying and drying/degassing after a hot cutting method. Hot cutting is implemented at water temperatures of 70° C. to 95° C. and with a liquid to solid ratio of 8 to 12:1.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: August 9, 2011
    Assignees: Uhde Inventa-Fischer GmbH, BKG Bruckmann & Kreyenborg
    Inventors: Kurt Hanimann, Eike Schulz Van Endert, Theodor Anton Bruckmann
  • Patent number: 7985058
    Abstract: A method and apparatus for making substantially uniformly sized liposomes and other small particles are provided. Droplets of a first liquid are ejected into a laminar flow of a second liquid, each droplet having a volume of from 0.97V to 1.03V, where V is the mean droplet volume and 1 fL?V?50 nL, wherein the first and second liquids are no more than sparingly soluble in one another, and wherein the first liquid contains a solute dissolved, dispersed, or suspended therein; and the first liquid is then removed to form a plurality of substantially uniformly sized particles. In one embodiment, the apparatus includes liquid inlet and outlet channels, a plurality of transverse liquid channels extending from the liquid inlet to the liquid outlet channel, a plurality of nozzles in liquid flow communication with the plurality of transverse liquid channels, one or more nozzle actuators coupled to the plurality of nozzles, and an evaporator coupled to the liquid outlet channel.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: July 26, 2011
    Inventor: Mark Gray
  • Publication number: 20110169178
    Abstract: The invention relates to a method for preparing a fuel based on oxide, carbide, and/or oxycarbide comprising uranium and at least one actinide and/or lanthanide component, comprising the following steps: a step for preparing a load solution consisting in a nitric solution comprising said actinide and/or lanthanide in the form of actinide and/or lanthanide nitrates and uranium as a hydroxylated uranyl nitrate complex; a step for passing said solution over a cation exchange resin comprising carboxylic groups, with which the actinide and/or the lanthanide in cationic form and the uranium as uranyl remain bound to the resin; a heat treatment step of said resin so as to obtain said fuel.
    Type: Application
    Filed: September 22, 2009
    Publication date: July 14, 2011
    Inventors: Sebastien Picart, Hamid Mokhtari, Isabelle Jobelin
  • Publication number: 20110163469
    Abstract: The high-throughput fabrication of microparticles based on the double emulsion/solvent evaporation technique for screening and optimizing microparticle formulations for particular characteristics allows for the preparation of multiple microparticle formulations in parallel. The system involves the formation of an emulsion containing aqueous bubbles with the payload in an organic phase containing the polymer or polymer blend being used for the microparticles. This first emulsion is then transferred to a larger aqueous phase, and a second waterin-oil-in water emulsion is formed. The organic solvent is then removed, and the resulting particles are optionally washed and/or freeze dried. The resulting microparticles are similar or better than microparticles prepared using the traditional one formulation at a time approach. The high-throughput fabrication of microparticles is particularly useful in optimizing microparticles formulations for drug delivery.
    Type: Application
    Filed: December 13, 2006
    Publication date: July 7, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Steven Little, Daniel G. Anderson, Robert S. Langer
  • Patent number: 7972543
    Abstract: An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 ?m, a depth of 10 ?m to 6000 ?m and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: July 5, 2011
    Assignees: National Agriculture and Food Research Organization, Kuraray Co., Ltd.
    Inventors: Mitsutoshi Nakajima, Taiji Nishi, Seiichi Kanai, Takenori Kitani, Motohiro Fukuda
  • Publication number: 20110160870
    Abstract: An implant system includes a fixation device that, in turn can include an expandable implant alone or in combination with an auxiliary implant. The expandable implant includes an expandable implant body that is made from an expandable material. The expandable material includes a polymer matrix and an expandable gas source contained within at least a portion of the polymer matrix. The implant system can further include an energy source configured to heat the polymer matrix to a temperature above its glass transition temperature, thereby causing the gas source to expand inside the polymer matrix. The fixation device can further include an insertion instrument configured to implant the fixation device into an anatomical cavity.
    Type: Application
    Filed: November 30, 2010
    Publication date: June 30, 2011
    Inventors: Adrian Baumgartner, Robert Frigg, Cyril Voisard, Reto Nardini, Dieter Schmidli, Christian Brunner, Stefan Saladin
  • Patent number: 7968020
    Abstract: Systems and methods for pelletizing hot asphaltenes are provided. Asphaltenic hydrocarbons can be dispersed to provide two or more asphaltenic particles. The asphaltenic hydrocarbons can be at a temperature of from about 175° C. to about 430° C. The asphaltenic particles can be contacted with a film of cooling medium. The film can have a thickness of from about 1 mm to about 500 mm. At least a portion of the asphaltenic particles can be solidified by transferring heat from the asphaltenic particles to the cooling medium to provide solid asphaltenic particles. The solid asphaltenic particles can be separated from at least a portion of the cooling medium.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: June 28, 2011
    Assignee: Kellogg Brown & Root LLC
    Inventors: Gary L. Behelfer, Maury Schlossman
  • Publication number: 20110147962
    Abstract: A process for preparing a spray-dried detergent powder having (i) detersive surfactant; and (ii) other detergent ingredients; wherein the process comprises the steps of: (a) forming an aqueous detergent slurry in a mixer; (b) transferring the aqueous detergent slurry from the mixer through at least one pump to a spray nozzle; (c) contacting alkoxylated anionic detersive surfactant and/or acid precursor thereof to the aqueous detergent slurry after the mixer and before the spray nozzle to form a mixture; (d) spraying the mixture through the spray nozzle into a spray-drying tower; and (e) spray-drying the mixture to form a spray-dried powder.
    Type: Application
    Filed: December 13, 2010
    Publication date: June 23, 2011
    Inventors: Larry Savio Cardozo, Hossam Hassan Tantawy, James Robert Lickiss, Nigel Patrick Somerville Roberts
  • Publication number: 20110147963
    Abstract: A process for preparing a spray-dried detergent powder including the steps of (i) mid-chain branched detersive surfactant; and (ii) other detergent ingredients; wherein the process includes the steps of: (a) forming an aqueous detergent slurry in a mixer; (b) transferring the aqueous detergent slurry from the mixer through at least one pump to a spray pressure nozzle; (c) contacting mid-chain branched detersive surfactant and/or acid precursor thereof to the aqueous detergent slurry after the mixer and before the spray pressure nozzle to form a mixture; (d) spraying the mixture through the spray pressure nozzle into a spray-drying tower; and (e) spray-drying the mixture to form a spray-dried powder.
    Type: Application
    Filed: December 13, 2010
    Publication date: June 23, 2011
    Inventors: Larry Savio CARDOZO, Hossam Hassan TANTAWY, James Robert LICKISS, Nigel Patrick SOMERVILLE ROBERTS
  • Publication number: 20110147964
    Abstract: A process for preparing a spray-dried powder having: (i) detersive surfactant; and (ii) other detergent ingredients; wherein the process has the steps of: (a) forming an aqueous detergent slurry in a mixer; (b) transferring the aqueous detergent slurry from the mixer in a pipe leading through at least one pump to a spray nozzle; (c) contacting a detergent ingredient to the aqueous detergent slurry in the pipe after the mixer and before the spray nozzle to form a mixture; (d) spraying the mixture through the spray nozzle into a spray-drying tower; and (e) spray-drying the mixture to form a spray-dried powder, wherein in step (c) the aqueous detergent slurry and the resultant mixture are in laminar flow, and wherein in step (c) the ratio of (i) the flow rate of the aqueous detergent slurry in kgmin?1 to (ii) the flow rate of the detergent ingredient in kgmin?1 is in the range of from 1 to 70.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Inventors: Larry Savio Cardozo, Hossam Hassan Tantawy, James Robert Lickiss, Nigel Patrick Somerville Roberts
  • Patent number: 7964123
    Abstract: Embolization, as well as related particles and methods, are described.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: June 21, 2011
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Janel L. Lanphere, Marcia S. Buiser, Thomas V. Casey
  • Publication number: 20110135734
    Abstract: The invention relates to a method for the production of nanoparticles from oil-in-water nanoemulsions, in which the nanoemulsion is prepared by phase inversion techniques. The phase inversion may be achieved by using a constant temperature, where the inversion occurs by continuous addition of water or by varying the temperature involving heating and rapid cooling.
    Type: Application
    Filed: April 20, 2005
    Publication date: June 9, 2011
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Shlomo Magdassi, Liat Spernath
  • Publication number: 20110133353
    Abstract: A method for producing inorganic spheroidized particles according to the present invention includes a step of producing the inorganic spheroidized particles by means of a diffusion type burner (12), wherein the burner (12) comprises a first raw material supply path (1A), a fuel supply path (4A), a raw material diffusion chamber (9), a primary oxygen supply path (5A), a second raw material supply path (6A), a secondary oxygen supply path (7A), and a combustion chamber (8).
    Type: Application
    Filed: July 31, 2009
    Publication date: June 9, 2011
    Inventors: Yoshiyuki Hagihara, Yasuyuki Yamamoto
  • Publication number: 20110130513
    Abstract: The present invention relates to a method for producing a bead-shaped polylactide pellets and the bead-shaped polylactide pellets prepared from the method thereof, and primarily includes an die-face cutting step, a dewatering step and a crystallization step. In which bead-shaped polylactide pellets are produced from a polylactide melt undergoing the die-face cutting step, the dewatering step and the crystallization step. The die-face cutting step is carried out by immersing the polylactide melt in water at a temperature of 50° C.˜90° C.; the dewatering step is carried out in an atmosphere temperature of 80° C.˜150° C.; the crystallization step is carried out in an atmosphere temperature 80° C.˜150° C. The bead-shaped polylactide pellets obtained have a water content of 10˜400 ppm, and smooth surfaces with no concave. The producing method of the present invention is thus able to achieve the objective of saving mass energy consumption.
    Type: Application
    Filed: November 26, 2010
    Publication date: June 2, 2011
    Inventors: Heng-Bo Chiang, Chen-Pao Huang
  • Publication number: 20110121473
    Abstract: A method for fabricating a sintered annular nuclear fuel pellet includes: molding nuclear fuel powder or granules to fabricate an annular nuclear fuel green body; inserting a rod-like shaped structure into the annular nuclear fuel green body; sintering the rod-like shaped structure-inserted annular nuclear fuel green body in a reductive gas atmosphere; and separating the sintered annular nuclear fuel pellet from the rod-like shaped structure.
    Type: Application
    Filed: August 30, 2010
    Publication date: May 26, 2011
    Applicants: KOREA ATOMIC ENERGY RESEARCH INSTITUTE, KOREA HYDRO & NUCLEAR POWER CO., LTD.
    Inventors: Young-Woo Rhee, Dong-Joo Kim, Jong-Hun Kim, Jae-Ho Yang, Ki-Won Kang, Chill Sun Ryu, Keon-Sik Kim, Kun-Woo Song
  • Publication number: 20110117157
    Abstract: The present invention offers a method of manufacture of sustained-release formulation composition which includes a step of spray drying a composition that contains (1) an active ingredient, (2) a resin ingredient, and (3) a solvent, using a spray dryer and controlling the exit temperature of the spray dryer, wherein solvent content in the composition after spray drying is 5 mass % or less, and the composition after the aforementioned spray drying does not substantially contain decomposed matter of the aforementioned active ingredient.
    Type: Application
    Filed: July 7, 2009
    Publication date: May 19, 2011
    Applicant: Nippon Soda Co., Ltd.
    Inventors: Yoshihisa Endo, Yoshio Nakamura, Shinya Fukuhara
  • Publication number: 20110118351
    Abstract: Disclosed herein are stabilized powder and aqueous formulations comprising a substantially water insoluble lipophilic bioactive compound and a micelle-forming surfactant. In one embodiment, the formulation further comprises a water soluble reducing agent, and/or a water insoluble reducing agent, and/or a metal chelator, and/or a metal bisulfite reducing agent, or combinations thereof, wherein the formulation remains substantially clear and stable when stored at or below room temperature for a period of at least 6 months or at least 12 months; and methods for preparing these formulations.
    Type: Application
    Filed: November 10, 2010
    Publication date: May 19, 2011
    Inventor: Volker Berl
  • Publication number: 20110118364
    Abstract: This invention concerns a manufacturing process for nanoparticles composted of biodegradable polymers and active ingredients with therapeutic, cosmetic, veterinary, and alimentary applications, and a composition which contains said nanoparticles, which are used in products for animals, including humans. The process consists of emulsifying the hydrosoluble substances to form a w/o emulsion; dissolving the non-emulsionable substances, liposoluble polymer or polymer/compounds in organic solvents; mixing the w/o emulsion and the organic solution of the hydrophobics to form a pre-emulsioned mixture; adding the pre-emulsioned mixture, with the assistance of an injector system, to an aqueous emulsifier solution under ultradispersion to form the final emulsion; leading the final emulsion to evaporation, then centrifuge, freeze, and lyophilize.
    Type: Application
    Filed: June 30, 2009
    Publication date: May 19, 2011
    Inventor: Fabio Moyses LINS DANTAS
  • Publication number: 20110100028
    Abstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 5, 2011
    Applicant: MannKind Corporation
    Inventors: Edwin Amoro, Karel Vanackere, Michael A. White
  • Publication number: 20110100439
    Abstract: A radioisotope power sources that includes radioisotope nanoparticles and scintillator materials. An embodiment of the radioisotope power source includes radioisotope nanoparticles suspended within a polycrystalline scintillator; additional polycrystalline scintillator at least partially surrounding the polycrystalline scintillator with the radioisotope nanoparticles; and a photovoltaic device in light communication with the surrounding polycrystalline scintillator. A system that employs the radioisotope power source and a method of generating an electrical current are also disclosed. The present invention has been described in terms of specific embodiment(s), and it is recognized that equivalents, alternatives, and modifications, aside from those expressly stated, are possible and within the scope of the appending claims.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 5, 2011
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Brent Allen Clothier, Matthew Christian Nielsen, Todd Ryan Tolliver, Allen Lawrence Garner
  • Publication number: 20110097409
    Abstract: Powder particles comprising a pharmaceutically acceptable salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone (carmoterol) having a specific properties exhibit improved adhesion properties for dry powder formulations for inhalation. Such particles are useful for formulations in the form of powders for inhalation and the treatment of certain conditions and diseases.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 28, 2011
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Francesca Buttini, Paolo Colombo, Chiara Parlati, Daniela Cocconi, Rossella Musa
  • Patent number: 7931834
    Abstract: A process for the formation of particles of a target material is disclosed, comprising: (i) introducing the target material into a particle formation vessel, and forming a continuous liquid surface of the target material in the particle formation vessel, and an interface between said liquid surface of the target material and additional gaseous contents of said particle formation vessel; (ii) introducing a stream of cryogenic material including solid particles of cryogenic material into the particle formation vessel and into contact with the target material in a liquid state below the continuous liquid surface; (iii) allowing rapid volumetric expansion of the cryogenic material into a gaseous state while in contact with the target material in a liquid state, and release of the expanded gaseous cryogenic material through the continuous liquid surface, and forming liquid droplet particles of the target material; and (iv) collecting the formed particles of the target material.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: April 26, 2011
    Assignee: Eastman Kodak Company
    Inventors: Rajesh V. Mehta, Robert Link, Michael A. Marcus
  • Publication number: 20110092598
    Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.
    Type: Application
    Filed: October 7, 2008
    Publication date: April 21, 2011
    Inventors: Nandu Deorkar, James Farina, Liliana Miinea, Sameer Randive
  • Publication number: 20110084238
    Abstract: The present invention relates to a process for preparing lithium vanadium oxides and also a process for producing mixtures of a lithium vanadium oxide and at least one electrically conductive material. Furthermore, the invention relates to the use of lithium vanadium oxides or of mixtures of a lithium vanadium oxide and at least one electrically conductive material for producing cathodes for batteries and in electrochemical cells. In addition, the invention relates to cathodes which comprise a lithium vanadium oxide or a mixture of a lithium vanadium oxide and at least one electrically conductive material.
    Type: Application
    Filed: May 28, 2009
    Publication date: April 14, 2011
    Applicant: BASF SE
    Inventors: Hartmut Hibst, Kirill Bramnik, Julian Proelss
  • Publication number: 20110086104
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 14, 2011
    Applicant: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Publication number: 20110080987
    Abstract: Among fuel rods constituting a fuel assembly, Gd compound oxide is added to low Gd containing fuel rods that containing uranium dioxide of which enrichment exceeds 5 wt %. The Gd compound oxide is oxide of gadolinium and rare earth element A except for gadolinium and is expressed as a chemical formula A1-xGdxO2-0.5x or a chemical formula A1-xGdxO1.5. As the rare earth element A, cerium Ce, lanthanum La or erbium Er can be used.
    Type: Application
    Filed: October 14, 2010
    Publication date: April 7, 2011
    Inventors: Souichi WATANABE, Hironori Kumanomido, Ishi Mitsuhashi, Satoshi Sugahara, Makoto Ueda
  • Patent number: 7919023
    Abstract: This invention relates to a process for manufacturing a dense material containing UO2, comprising: a) introducing at least two powders each comprising uranium dioxide UO2 into a vibrating grinder, wherein at least two powders are provided by two different synthesis routes and each powder has a specific surface area close to that of any other uranium-dioxide containing powder introduced into said grinder; b) shaking said powders by means of said vibrating grinder so as to form a particulate material, the grinding intensity being sufficient to break up the agglomerates and the aggregates in the powders without at the same time breaking up the crystallites in the powders, and the grinding energy provided to the powders being such that substantially all of the agglomerates and aggregates are destroyed; c) introducing said particulate material into a mould; d) applying a shaping stress to said particulate material in order to obtain a compacted material; e) carrying out the sintering of said compacted material so
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: April 5, 2011
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Philippe Sornay, Eric Bertrand
  • Patent number: 7919119
    Abstract: Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: April 5, 2011
    Assignee: Acusphere, Inc.
    Inventors: Julie Straub, David Altreuter, Howard Bernstein, Donald E. Chickering, III, Sarwat Khattak, Greg Randall
  • Publication number: 20110076499
    Abstract: A solid a-sulfo fatty acid alkyl ester salt having a bubble volume fraction of 1 to 15% is provided by introducing a gas into a paste of a-sulfo fatty acid alkyl ester salt or adding thereto an expanding agent to incorporate bubbles into the paste of a-sulfo fatty acid alkyl ester salt.
    Type: Application
    Filed: May 25, 2009
    Publication date: March 31, 2011
    Applicant: Lion Corporation
    Inventors: Hiroyuki Masui, Naoki Nakamura, Takao Matsuo
  • Patent number: 7901606
    Abstract: The present invention provides a method of producing porous structures, particles or matrixes, which may be comprised of one or a plurality of components, an apparatus for carrying out the method and particles formed in accordance with the method. The method is particularly suitable for producing porous composite or pure particles for pharmaceutical applications. In accordance with the method, a composite comprising a material such as a pharmaceutical, a biodegradable polymers and/or a biological agent is formed. The composite must further comprise a material that is soluble in supercritical fluid. Extraction of the supercritical fluid soluble material produces porous structures, which may be in the form of particles or matrixes.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: March 8, 2011
    Assignee: Ferro Corporation
    Inventors: Pratibhash Chattopadhyay, Boris Y. Shekunov, Jeffrey S. Seitzinger
  • Patent number: 7901712
    Abstract: An novel gliclazide nanosphere, the manufacturing method therefor and the application thereof are provided in the present application is provided. The gliclazide nanosphere is prepared by reacting the solid gliclazide with a polymeric matrix for improving the dissolution property and safety of gliclazide, and is benefit for immediately releasing dosage application in clinical therapy.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: March 8, 2011
    Assignee: Kaoshiung Medical University
    Inventors: Yung-Kuang Lo, Thau-Ming Cham
  • Patent number: 7902284
    Abstract: Organosilicon compositions which can be cured to produce elastomers, in particular elastomers suitable for use in the food industry, contain very fine particulate aluminum oxide powder in minor amount. Non-blocking sheets and pellets can be formed from the compositions, and later molded and cured.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: March 8, 2011
    Assignee: Wacker Chemie AG
    Inventor: Peter Jerschow
  • Publication number: 20110049734
    Abstract: A method for fabricating a sintered annular nuclear fuel pellet includes molding nuclear fuel powder or granule, an oxide of a fissile element (M), to fabricate an annular nuclear fuel green body. A rod-like shaped structure is inserted into the annular nuclear fuel green body and sintered in a slight oxidizing gas atmosphere such that the oxide of the fissile element has a balanced O/M ratio higher than a desired O/M ratio (oxygen/fissile element) of a final sintered annular nuclear fuel pellet, while being maintained in a cubic phase. The sintered annular nuclear fuel pellet is then reduced in a reductive gas atmosphere so as to have the desired O/M ratio in the state that the rod-like shaped structure is inserted.
    Type: Application
    Filed: August 30, 2010
    Publication date: March 3, 2011
    Applicants: KOREA ATOMIC ENERGY RESEARCH INSTITUTE, KOREA HYDRO & NUCLEAR POWER CO., LTD.
    Inventors: Young-Woo Rhee, Dong-Joo Kim, Kun-Woo Song, Jong-Hun Kim, Keon-Sik Kim, Jae-Ho Yang, Ki-Won Kang, Chill Sun Ryu
  • Patent number: 7892461
    Abstract: Description of a method for the production of a pigmented thermoplastic material. The method characterizes that during a first step an aqueous suspension presenting a solid matter contents of approximately 10 to 75% by weight, containing at least one flow enhancer in form of dissolved salt and the pigment, is ground under alkaline conditions in a high energy charging mill by means of grinding bodies having a diameter of 0.2 to 2 mm, and the obtained grinding product is transformed during a second step with a thermoplastic material into the pigmented thermoplastic material by means of a flush process performed by a kneader or extruder, at increased temperature and a pH value of initially 7 or less. In addition, the invention concerns a pigmented thermoplastic material produced according to said method, as well as beneficial applications for production of transparent molded bodies, in particular of fibers, foils, injection moldings and extruded parts.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: February 22, 2011
    Assignee: Heubach GmbH
    Inventors: Gerard E. Maratta, Rainer Heubach
  • Publication number: 20110028570
    Abstract: A process for making a self-emulsifying granule suitable for use in forming latex emulsions includes contacting a resin with a solid or highly concentrated surfactant, a solid neutralization agent and water in the absence of an organic solvent to form a mixture, melt mixing the mixture, and forming self-emulsifying granules of the melt mixed mixture. Self-emulsifying granules are also provided and configured to form a latex emulsion when added to water.
    Type: Application
    Filed: July 30, 2009
    Publication date: February 3, 2011
    Applicant: XEROX CORPORATION
    Inventors: Santiago Faucher, Joo T. Chung, Shigang Qiu, Fumii Higuchi
  • Publication number: 20110020647
    Abstract: This invention provides a process for producing fine PPS resin particles and a dispersion thereof by industrially applicable simple operation. This invention further provides very fine PPS resin particles, and furthermore provides fine PPS resin particles uniform in particle size. This invention is a process for producing fine polyphenylene sulfide resin particles comprising the following steps (a) and (b): (a) A step of heating a polyphenylene sulfide resin in an organic solvent, for obtaining a solution with the polyphenylene sulfide resin dissolved therein (dissolution step) (b) A step of flush-cooling the aforementioned solution, for precipitating the fine particles of the polyphenylene sulfide resin (precipitation step).
    Type: Application
    Filed: March 23, 2009
    Publication date: January 27, 2011
    Inventors: Kei Makita, Takae Ono, Toshiya Takahashi, Hiroaki Akasaka, Tomohiro Sakane
  • Patent number: 7875295
    Abstract: A process for the production of a microparticle or a nanoparticle of a chemical compound comprising the steps of providing a solution of said chemical compound in a first liquid; providing a second liquid in which said chemical compound is insoluble or substantially insoluble; combining said liquids in a region of high shear thereby causing formation of said particles; and isolating said particles of said compound. The processing time of a coacervation style process can be reduced and the yield can be substantially increased both by control of the precipitation step which allows for desolvation step to be dispensed with leading to significant process time reduction. The invention also provides a molecular mixing unit comprising an outer body defining a mixing zone; a shear means to provide shear liquid in said mixing zone; at least one fluid inlet means for a first liquid; at least one fluid inlet means for a second liquid and a fluid outlet means.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: January 25, 2011
    Assignee: Nanomaterials Technology Pte Ltd
    Inventors: Sung Lai Jimmy Yun, Jian Feng Chen
  • Publication number: 20110006449
    Abstract: Disclosed herein are processes for making a plurality of substantially phase-pure metal oxide particles, the particles comprising a garnet structure, the process comprising: subjecting a dispersion of precursors to a solvothermal treatment to form a garnet intermediate and applying a flow-based thermochemical process to said garnet intermediate.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 13, 2011
    Inventors: Rajesh Mukherjee, Toshitaka Nakamura, Sheng Li, Brett T. Harding, Amane Mochizuki
  • Patent number: 7863345
    Abstract: A process for producing a microparticulate hardening catalyst, comprising the steps of jetting a liquid composition containing epoxy resin hardening catalyst (A), monomer having an ethylenically unsaturated group (B) and photopolymerization initiator (C) through a minute nozzle into a gas so as to form microparticles; and while the microparticles are floating, irradiating the same with high-energy rays to thereby effect polymerization of the monomer having an ethylenically unsaturated group (B).
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: January 4, 2011
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Hiroo Koyanagi, Makoto Uchida, Shigeru Moteki
  • Patent number: 7862751
    Abstract: The invention provides a method for manipulating or formulating a solid substance which melts under pressure of a gas without degrading at a temperature lower than the melting point of the substance at atmospheric pressure including: applying to the substance a liquefied gas or dense gas to melt the substance without degrading the substance; then contacting the molten substance with a carrier fluid, which is at substantially the same pressure as the liquefied gas or dense gas, to form a solution or mixture of at least a part of the molten substance and the carrier fluid; and passing the solution or mixture into a vessel of lower pressure than the pressure of the liquefied gas or dense gas and carrier fluid to form particles of the substance; and particles formed by the method.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: January 4, 2011
    Assignee: MAP Pharmaceuticals, Inc.
    Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani, Andrian Tandya
  • Publication number: 20100320628
    Abstract: An underwater pelletizer is presented having an electromagnetic clamp that includes an electromagnetic ring body having a series of electromagnets disposed along a contact surface of the electromagnetic ring body. A clamping ring body has a series of mild steel inserts disposed along a contact surface of the clamping ring body, where each mild steel insert is disposed in a position complementary to at least one of the series of electromagnets. The electromagnetic clamp ring has a contact face with a series of electromagnets disposed therein and providing a clamping ring having a contact face with a series of mild steel inserts disposed therein, where the contact face of the clamping ring is configured to engage the contact face of the electromagnetic ring to form a seal and the mild steel inserts are positioned such that each one of the series of electromagnets is adjacent to one of the mild steel inserts when the contact faces of the electromagnetic and clamping rings are engaged.
    Type: Application
    Filed: June 18, 2010
    Publication date: December 23, 2010
    Inventor: George A. Holmes
  • Publication number: 20100314788
    Abstract: A system and method for making ultrafine particles are disclosed. A high temperature plasma is generated at an inlet end of a plasma chamber into which precursor materials are introduced. A converging member is located adjacent an outlet end of the plasma chamber. During operation, a substantially constant pressure and/or material flow pattern is maintained to reduce or eliminate fouling of the system.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 16, 2010
    Inventors: Cheng-Hung Hung, Noel R. Vanier
  • Publication number: 20100314787
    Abstract: A method of producing a granular substance comprising (i) a step of melting a compound of the formula (1): (wherein, R1 and R2 represent each independently a hydrogen atom, alkyl group having 1 to 8 carbon atoms or cycloalkyl group having 5 to 8 carbon atoms, R3 represents a hydrogen atom or alkyl group having 1 to 8 carbon atoms. X represents a single bond, sulfur atom, oxygen atom, alkylidene group having 1 to 8 carbon atoms or cycloalkylidene group having 5 to 8 carbon atoms) to obtain the melted substance, and (ii) a step of dropping the melted substance obtained in the step (i) into water and recovering the granular substance.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 16, 2010
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Kazuhiro KITAMURA