Microscope Patents (Class 348/79)
  • Patent number: 10706536
    Abstract: A photonic structural and chemometric pathology system for cancer and precancerous or general detection, diagnosis, monitoring and prognosis utilizes fresh or frozen tissue standard pathology sections without prior as staining or other labeling techniques. The unlabeled tissue section may be imaged, with a phase and fluorescence imaging microscope, to obtain phase differential contrast (Q-DIC) images and fluorescence images. The Q-DIC images are analyzed to generate two dimensional Q-DIC data maps, such as morphology, cell mass, and scattering characteristic digital image maps. The fluorescence images are analyzed to generate fluorescence intensity and tissue native fluorescent component absolute concentration maps. The combination of Q-DIC data maps and fluorescent component content maps is comparatively analyzed to perform cancer and pre-cancerous or general diagnosis and prognosis.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: July 7, 2020
    Inventor: Min Xu
  • Patent number: 10698191
    Abstract: A microscope system and method allow for a desired x?-direction scanning along a specimen to be angularly offset from an x-direction of the XY translation stage, and rotates an image sensor associated with the microscope to place the pixel rows of the image sensor substantially parallel to the desired x?-direction. The angle of offset of the x?-direction relative to the x-direction is determined and the XY translation stage is employed to move the specimen relative to the image sensor to different positions along the desired x?-direction without a substantial shift of the image sensor relative to the specimen in a y?-direction, the y?-direction being orthogonal to the x? direction of the specimen. The movement is based on the angle of offset.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 30, 2020
    Assignee: NANOTRONICS IMAGING, INC.
    Inventors: Matthew C. Putman, John B. Putman, Brandon Scott, Dylan Fashbaugh
  • Patent number: 10690898
    Abstract: A light-field microscope includes a light-sheet focusing device configured for outputting illumination light as a light sheet, and a microlens array between an objective lens and a light detector. A sample is irradiated by the light sheet along a direction non-parallel to the sample plane. Light-field data may be acquired from the sample without needing to scan through the thickness of the sample. The microscope implements light-field acquisition in conjunction with selective plane illumination.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: June 23, 2020
    Assignee: Molecular Devices (Austria) GMBH
    Inventors: Josef Atzler, Andreas Kenda
  • Patent number: 10690899
    Abstract: An image observation device configured to: generate a reference image on a basis of one or more two-dimensional images of a Z-stack image constituted of two-dimensional images acquired by shifting a focal position; generate, on the generated reference image, a frame having window portions covering different small regions and superimposed on the reference image; allow a user to operate the generated frame; allocate different focal ranges to the respective window portions of the frame; generate, for the respective small regions covered by the respective window portions, omnifocal images by using, among the two-dimensional images in regions corresponding to the respective small regions, the two-dimensional images in the focal ranges allocated to the respective window portions; replace the regions of the reference image in the respective window portions with the respective generated omnifocal images based on the different focal ranges; and display the reference image, the frame, and the omnifocal images.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: June 23, 2020
    Assignee: OLYMPUS CORPORATION
    Inventor: Yoko Abe
  • Patent number: 10665001
    Abstract: Certain aspects pertain to Fourier ptychographic tomographic systems and methods for acquiring a plurality of uniquely illuminated intensity measurements based on light passing through a thick sample from plane wave illumination at different angles and for constructing three-dimensional tomographic data of the thick sample by iteratively determining three-dimensional tomographic data in the Fourier domain that is self-consistent with the uniquely illuminated intensity measurements.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 26, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Roarke W. Horstmeyer, Changhuei Yang
  • Patent number: 10649197
    Abstract: A magnified observation apparatus includes: an observation unit including a light source and an imaging unit; a light quantity parameter table recording unit configured to store plural light quantity parameter tables therein, each of the plural light quantity parameter tables including: a minimum value and a maximum value of light quantity of illumination light; and a unit manipulation amount obtained by division of an interval between the minimum value and the maximum value by a predetermined division number, maximum values in the plural light quantity parameter tables being different from one another; a light quantity parameter selecting unit configured to select one light quantity parameter table from the plural light quantity parameter tables; and a light source control unit configured to increase or decreases light quantity of the illumination light, correspondingly to magnitude of the unit manipulation amount in the selected light quantity parameter table.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: May 12, 2020
    Assignee: OLYMPUS CORPORATION
    Inventor: Shodai Hosono
  • Patent number: 10643270
    Abstract: A smart product display system has a base on which a product can be placed. A product camera mounted to the base is used to image a field of view over the base. Images from the product camera are analyzed to identify products that are placed on the base and to detect when a customer has interacted with a product, such as by lifting it up. When a product interaction is detected, information about the product is presented on a display. The display can be integrated in a riser extending upwardly from the base. A customer camera can be used to capture images of a person in the vicinity of the system. Images from the customer camera can be analyzed to identify an attribute of an imaged person and an output, such as a content display or an alert, generated responsive to the attribute.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: May 5, 2020
    Assignee: Conex Digital LLC
    Inventors: Jean Vieville, Louis Dupere, Nicolas Lorin, Waqas Nadeem, Deepan Sekar
  • Patent number: 10634151
    Abstract: A certain material irregularly expressed in an observation area is effectively observed. An observing apparatus includes a first observing unit performing a time lapse shooting of a predetermined observation area, a first discriminating unit discriminating whether or not a first material is expressed in the observation area based on an image obtained by the first observing unit, and a second observing unit starting a time lapse shooting relating to a part where the first material is expressed at a timing when the first material is expressed in the observation area, in which a shooting frequency of the time lapse shooting by the second observing unit is higher than a shooting frequency of the time lapse shooting by the first observing unit.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: April 28, 2020
    Assignee: NIKON CORPORATION
    Inventor: Hiroaki Kii
  • Patent number: 10634889
    Abstract: Provided are a medical observation apparatus and a medical observation system that are optimal in manipulability and favorable for downsizing and include: an observation unit including a microscope unit that is configured to collect light from an object to be observed via one end in a height direction of the microscope unit and capture a magnified image of a minute part of the object to be observed and has a columnar shape to be grasped by a user during movement, a center of gravity of which observation unit is located farther from the one end than a center in the height direction is; and a support unit supporting the observation unit in a rotationally movable manner around an axis passing through the center of gravity or a vicinity of the center of gravity and perpendicular to the height direction.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: April 28, 2020
    Assignee: SONY OLYMPUS MEDICAL SOLUTIONS INC.
    Inventors: Shigeru Tamura, Kenji Hirose, Yoshiyuki Kamata
  • Patent number: 10606057
    Abstract: A microscope system includes a microscope apparatus and a controller. The microscope apparatus includes an objective and a correction device that corrects a spherical aberration. The controller, during an interval period of a time-lapse observation, detects a reference target position of an observation target and updates correction information on the basis of at least variation information, the correction information representing a relationship between a position of the objective and a setting of the correction device and the variation information representing a variation amount of a distance from the objective to the reference target position. The controller, during an observation period of the time-lapse observation, controls the correction device in accordance with the correction information for each position of the objective determined on the basis of at least the variation information.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 31, 2020
    Assignee: OLYMPUS CORPORATION
    Inventor: Kanako Isono
  • Patent number: 10585271
    Abstract: A method for examining a sample includes illuminating the sample in an illumination plane along an illumination strip by an illuminating light beam which propagates along the illumination strip. The illumination strip is projected into a detection plane by detection light originating from the illumination strip being focused in the detection plane. The detection light is detected by a detector. The detector is formed as a slit detector, and the direction of a slit width of the slit detector is oriented at an angle different from zero degrees with respect to the direction of a longitudinal extent of an image of the illumination strip projected into the detection plane.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: March 10, 2020
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Florian Fahrbach, Werner Knebel
  • Patent number: 10585042
    Abstract: A system for analyzing one or more liquid samples includes a microwell plate including a plurality of rows of wells configured to store liquid samples, a sensor array that is moveable relative to the microwell plate along a first axis between a first position and a second position to allow a portion of the sensor array to be disposed within a first one of the plurality of rows of wells when the sensor array is in the second position, an objective, and one or more linear translation stages configured to move the microwell plate relative to the objective (i) along a second axis that is orthogonal to the first axis, (ii) along a third axis that is orthogonal to the first axis and the second axis, or (iii) both (i) and (ii).
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 10, 2020
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, NANOVIEW BIOSCIENCES, INC.
    Inventors: M. Selim Ünlü, Derin Sevenler, Jacob Trueb, Oguzhan Avci, Celalettin Yurdakul, Steven Scherr, George G. Daaboul, David S. Freedman
  • Patent number: 10578851
    Abstract: An automated slide scanning system, comprising one or more optical elements, including an objective, having an optical path configured to be disposed within view of a camera of a portable device. An automated stage disposed within the optical path, the automated stage comprising a platform configured for receiving a slide containing a biological sample and having a drive mechanism for translating the stage in at least one direction with respect to said objective. A communications interface coupled to the automated stage, and is configured for receiving a command from the portable device to control operation of the mechanical stage.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: March 3, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel A. Fletcher, Michael V. D'Ambrosio, Arunan Skandarajah, Frank B. Myers, III, Clay D. Reber
  • Patent number: 10565428
    Abstract: Disclosed is a micro-localisation device defining a system of spatial coordinates for an imaging instrument. The micro-localisation device includes at least one first zone and a second zone, adjacent to each other, each zone extending spatially over an area of macroscopic size, each zone including an elementary cell or a tiling of a plurality of elementary cells extending over the respective area of the zone, each elementary cell of the first, respectively second, zone including an orientation pattern, a positioning pattern and a periodic spatial pattern, configured to be imaged by an imaging instrument and to determine a position and, respectively an orientation of the imaging instrument in the system of spatial coordinates of the micro-localisation device.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: February 18, 2020
    Assignee: HORIBA FRANCE SAS
    Inventors: Olivier Acher, Simon Richard, Melanie Gaillet, Alexander Podzorov, Adrian Knowles
  • Patent number: 10567681
    Abstract: A method for multi-line detection, in which a number M of regions Rm to be read, with m=1, . . . , M, is specified on a two-dimensional detector connected to an actuator. In each region to be read, a number J of row groups in each case of adjacent detector rows is specified, wherein each row group comprises a predefined number N of detector rows. In order to be able to record light in several areas on the detector at the same time, integration process are started successively in all participating rows and, after these have been ended, read processes are started. A read time is available for the reading of each row, this read time also corresponds to the temporal offset in which the integration processes are started row by row. An actual exposure, controlled via a corresponding signal, is effected only when integration processes have actually been started in all participating rows and the first integration process has not yet been ended again.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 18, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Martin Beck
  • Patent number: 10567719
    Abstract: A method for correcting colors of a color reproduction of a digital microscope and a digital microscope are described. In a first step of a method according to the invention, a color image of a sample that is to be examined under the microscope is recorded. When the recording is performed, wavelength-dependent properties of a microscope illumination unit that illuminates the sample are determined in order to describe a state of the microscope illumination unit, in that settings selected at the microscope illumination unit are captured. A set of correction values is determined, which is associated with a state of the microscope illumination unit that is selected in accordance with the state of the microscope illumination unit determined when the recording is performed. In a further step, the colors of the recorded color image of the sample are corrected by applying the correction values of the previously determined set.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: February 18, 2020
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Alexander Gaiduk, Burkhard Goetz, Stanislav Kalinin, Michael Wacke, Markus Jaeger
  • Patent number: 10558030
    Abstract: A structured illumination microscopy system including an illumination optical system illuminating excitation light to excite a fluorescent material contained in a sample on the sample with an interference fringe; a controlling part controlling a direction, a phase, and a spatial frequency of the interference fringe; an image-forming optical system forming an image of the sample which is modulated by illumination of the interference fringe; an imaging sensor capturing the image formed by the image-forming optical system; and a demodulating part performing demodulation processing by using a plurality of images captured by the imaging sensor in which the controlling part controls the spatial frequency of the interference fringe in accordance with an illuminating position of the interference fringe.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: February 11, 2020
    Assignee: NIKON CORPORATION
    Inventor: Yumiko Ouchi
  • Patent number: 10554899
    Abstract: The present disclosure generally relates to HDR imaging techniques, and more specifically to HDR imaging techniques for use when a scene is moving. For time delay integration, the same scene location is repeatedly imaged on sequential rows, allowing for different gain values and/or exposure times to be utilized in different rows. The present disclosure utilizes a static or dynamic selection of gain values and/or exposure times on each row to enable stitching of the rows for high dynamic range.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 4, 2020
    Assignee: Goodrich Corporation
    Inventors: Robert Brubaker, Gavin Dyer, Davis A. Lange
  • Patent number: 10538729
    Abstract: There is provided a cell imaging control device, method, and a non-transitory computer readable recording medium recorded with a program capable of performing focus control more efficiently when imaging cells being cultured and improving the focus accuracy. There are included: an information acquisition unit 22 that acquires at least one of information regarding the maturity of cells being cultured or observation position information of the cells in a colony; a focus parameter determination unit 23 that determines a focus parameter based on at least one of the information regarding the maturity of the cells or the observation position information; and a focus control section 25 that performs focus control in an imaging device, which captures an image of the cells, based on the focus parameter.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: January 21, 2020
    Assignee: FUJIFILM Corporation
    Inventor: Tsuyoshi Matsumoto
  • Patent number: 10539772
    Abstract: A method of imaging a live biological specimen includes generating one or more first light sheets; directing the generated one or more first light sheets along respective paths that are parallel with a first illumination axis such that the one or more first light sheets optically interact with at least a portion of the biological specimen in a first image plane; recording, at each of a plurality of first views, images of fluorescence emitted along a first detection axis; generating one or more second light sheets; directing the generated one or more second light sheets along respective paths that are parallel with a second illumination axis such that the one or more second light sheets optically interact with at least a portion of the biological specimen in a second image plane, and recording, at each of a plurality of second views, images of fluorescence emitted along a second detection axis.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: January 21, 2020
    Assignee: Howard Hughes Medical Institute
    Inventors: Philipp Johannes Keller, Raghav Kumar Chhetri
  • Patent number: 10539775
    Abstract: When acquiring a navigation image, to make it possible to set conditions the same as conditions under which a navigation image is acquired last time and create a natural navigation image. A navigation-image acquiring section controls a placement-table control section on the basis of designation of addition of a region to a navigation image and, when present imaging conditions are different from the last imaging conditions, changes the imaging conditions to the last imaging conditions, acquires a region to be added with an imaging element, and causes a display section to display an image of the acquired region to be added and an existing navigation image.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: January 21, 2020
    Assignee: Kerence Corporation
    Inventors: Shunsuke Tanaka, Jun Tabuchi, Takuya Karube, Norio Shibata
  • Patent number: 10535709
    Abstract: An optoelectronic device including a substrate with first and second opposite surfaces; and electrical insulation side elements extending from the first surface to the second surface and defining, within the substrate, first semi-conductive or conductive portions which are electrically insulated from each other. The optoelectronic device also includes, for each first portion a first conductive contact pad on the second surface in contact with the first portion and a set of light-emitting diodes resting on the first surface and electrically connected to the first portion. The optoelectronic device also includes a conductive, at least partially transparent electrode layer covering all the light-emitting diodes; an insulating, at least partially transparent encapsulation layer covering the electrode layer; and at least one second conductive contact pad electrically connected to the electrode layer.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: January 14, 2020
    Assignee: Aledia
    Inventors: Xavier Hugon, Ivan-Christophe Robin
  • Patent number: 10527404
    Abstract: The present invention relates to a method for ascertaining a focus image distance of an optical sensor, which is provided with a lens, of a coordinate-measuring machine onto a workpiece to be measured, wherein the optical sensor and the workpiece are movable relative to one another in a Z direction such that a distance in the Z direction between the workpiece and the optical sensor is variable. The present invention furthermore relates to a corresponding coordinate-measuring machine and to a computer program product.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: January 7, 2020
    Assignee: CARL ZEISS INDUSTRIELLE MESSTECHNIK GMBH
    Inventor: Christian Fiekers
  • Patent number: 10523880
    Abstract: One example system comprises a LIDAR sensor that rotates about an axis to scan an environment of the LIDAR sensor. The system also comprises one or more cameras that detect external light originating from one or more external light sources. The one or more cameras together provide a plurality of rows of sensing elements. The rows of sensing elements are aligned with the axis of rotation of the LIDAR sensor. The system also comprises a controller that operates the one or more cameras to obtain a sequence of image pixel rows. A first image pixel row in the sequence is indicative of external light detected by a first row of sensing elements during a first exposure time period. A second image pixel row in the sequence is indicative of external light detected by a second row of sensing elements during a second exposure time period.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: December 31, 2019
    Assignee: Waymo LLC
    Inventors: Blaise Gassend, Benjamin Ingram, Andreas Wendel, Mark Alexander Shand
  • Patent number: 10495864
    Abstract: A fluorescence observation apparatus includes a fluorescence observation unit, which includes a scanner that scans ultrashort pulsed laser light from a light source, a pupil projection lens that focuses the laser light scanned by the scanner, an image-forming lens that converts the focused laser light to substantially collimated light and causes the laser light to be incident on an objective lens, and a dichroic mirror that splits off fluorescence that is generated by the laser light focused on a sample by the objective lens and is collected by the objective lens. A photodetector detects the fluorescence split off by the dichroic mirror. A multi-mode optical fiber connects the fluorescence observation unit and the photodetector. A swiveling mechanism causes the fluorescence observation unit to swivel about an axis near the focal position of the objective lens. And a light-source optical fiber connects the light source and the fluorescence observation unit.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: December 3, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Makio Ueno, Masahito Oohi, Atsuhiro Tsuchiya, Hiroyasu Hebiishi
  • Patent number: 10459208
    Abstract: In a sample, fluorescence emitters are repeatedly excited to emit fluorescence, and still images are produced of the sample by means of a microscope. At least a subset of the fluorescence emitters is isolated in each still image. The positions of the fluorescence emitters are localized in the still images with a location accuracy exceeding the optical resolution. A high-resolution composite image is generated therefrom. An adaptive mirror is arranged in the imaging beam path, and is adjusted in such a manner that it produces an astigmatism when at least one of the still images is produced. As a result, still images with astigmatism are captured. Depth position information for the fluorescence emitters is derived from the rotational asymmetry. The adaptive mirror is additionally adjusted in such a manner that it does not produce any astigmatism when some of the still images are produced.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: October 29, 2019
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Thomas Kalkbrenner, Ralf Wolleschensky
  • Patent number: 10430933
    Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: October 1, 2019
    Assignee: The Bringham and Women's Hospital, Inc.
    Inventors: Antonio Carlos Sobieranski, Utkan Demirci, Huseyin Cumhur Tekin, Fatih Inci
  • Patent number: 10416426
    Abstract: A microscope system and method allow for a desired x?-direction scanning along a specimen to be angularly offset from an x-direction of the XY translation stage, and rotates an image sensor associated with the microscope to place the pixel rows of the image sensor substantially parallel to the desired x?-direction. The angle of offset of the x?-direction relative to the x-direction is determined and the XY translation stage is employed to move the specimen relative to the image sensor to different positions along the desired x?-direction without a substantial shift of the image sensor relative to the specimen in a y?-direction, the y?-direction being orthogonal to the x? direction of the specimen. The movement is based on the angle of offset.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 17, 2019
    Assignee: NANOTRONICS IMAGING, INC.
    Inventors: Matthew C. Putman, John B. Putman, Brandon Scott, Dylan Fashbaugh
  • Patent number: 10412374
    Abstract: The present disclosure relates to an image processing apparatus and an image processing method capable of changing an imaging method of an image by using a depth image in a pseudo manner. A pseudo image generation unit generates, as a pseudo image, a predicted value of a captured image of a subject captured by a predetermined imaging method from an image on the basis of a value of a parameter determined in accordance with a characteristic of the image, and a depth image indicating a position of the subject in the input image in a depth direction. The present disclosure is applicable to an image processing apparatus which generates a pseudo image corresponding to a predicted value of a captured image of a subject captured by a predetermined imaging method from an input image, for example.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: September 10, 2019
    Assignee: SONY CORPORATION
    Inventor: Seiji Kimura
  • Patent number: 10409049
    Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 10, 2019
    Assignee: Leica Biosystems Imaging, Inc.
    Inventors: Yunlu Zou, Nicholas Newberg, Gregory Crandall
  • Patent number: 10401291
    Abstract: A standing wave interferometric microscope is disclosed herein. An example microscope may include an illuminator, for illuminating a specimen with a standing wave of input radiation at an analysis location to cause the specimen to fluoresce, the specimen arranged in the analysis location, a pair of projection systems, arranged at opposite sides of the analysis location, coupled to collect at least a portion of the fluorescence and direct a corresponding pair of fluorescence light beams into a respective pair of inputs of an optical combining element, a wavefront modifier for producing astigmatism in at least one of the fluorescence light beams entering the optical combining element, and a detector for examining output light from said combining element.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 3, 2019
    Assignee: FEI COMPANY
    Inventors: Rainer Daum, Xaver Voegele
  • Patent number: 10401605
    Abstract: A system, including a structured illumination stage to provide a spatially modulated imaging field is provided. The system further includes a spatial frequency modulation stage to adjust the frequency of the spatially modulated imaging field, a sample interface stage to direct the spatially modulated imaging field to a sample, and a sensor configured to receive a plurality of fluorescence emission signals from the sample. The system also includes a processor configured to reduce a sample scattering signal and to provide a fluorescence emission signal from a portion of the sample including the spatially modulated imaging field. A method for using the above system to form an image of the sample is also provided.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 3, 2019
    Assignees: SCREEN HOLDINGS, CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Joseph Russell Landry, Ryosuke Itoh, Michael J. Mandella, Olav Solgaard
  • Patent number: 10379331
    Abstract: Lights in a plurality of emitting directions different from one another are selectively irradiated on the observation target from a light projecting section. A plurality of image data indicating images of the observation target at the time when the lights in the plurality of emitting directions are respectively irradiated on the observation target are generated by an imaging section. An imaginary emitting direction of light is designated on the basis of operation of an operation section by the user. Image data for display indicating an image of the observation target that should be obtained when it is assumed that the light in the designated emitting direction is irradiated on the observation target is generated on the basis of the designated emitting direction and the plurality of image data generated by the imaging section. The image based on the generated image data for display is displayed on the display section.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 13, 2019
    Assignee: KEYENCE CORPORATION
    Inventors: Masahiro Inomata, Shingo Matsumura
  • Patent number: 10382733
    Abstract: An image processing method, applied to a device including a sensor and a processor connected to the sensor, the sensor including a plurality of pixels, in which each of the pixels senses three primary colors and an infrared ray of an image, the processor executing the method including: calculating a real response value of the infrared ray without a crosstalk interference from the three primary colors according to the crosstalk interference from the three primary colors to the infrared ray; calculating real response values of the three primary colors without a crosstalk interference from the infrared ray according to the crosstalk interference of the real response value from the infrared ray to the three primary colors; and increasing a brightness of the image according to a brightness of the real response value of the infrared ray and the real response values of the three primary colors.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: August 13, 2019
    Assignee: REALTEK SEMICONDUCTOR CORP.
    Inventor: Wen-Tsung Huang
  • Patent number: 10360256
    Abstract: Provided is a microscope-image browsing system including: a server that stores multidimensional microscope images; and one or more client terminals that are connected to the server via a network, wherein each of the client terminals is provided with: an input portion with which microscope images and a playback direction are input; an information-transmitting portion that transmits the input information about the microscope images and the playback direction; an image-receiving portion that receives the microscope images; a storage portion that stores the received microscope images; and an image-playing-back portion that plays back the stored microscope images, and wherein the server is provided with: an information-receiving portion that receives the information transmitted thereto from the information-transmitting portion; and an image-delivering portion that, on the basis of the received information about the microscope images and the playback direction, preferentially delivers the microscope images arrayed
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 23, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Mina Kobayashi
  • Patent number: 10317655
    Abstract: The invention relates to a microscope for the molecular spectroscopic analysis of a sample (2), having a beam path having at least one quantum cascade laser (QCL) (3) which emits an infrared (IR) radiation, a phase modulator (5) which is arranged between the QCL (3) and the sample (2), at least one optical element (6) which is arranged between the phase modulator (5) and the sample (2) and a sensor (4) which detects an IR radiation which is transmitted and/or reflected by the sample (2). The invention relates further to a method for the molecular spectroscopic analysis of a sample (2) comprising the steps of irradiating the sample (2) with an infrared (IR) radiation by means of a quantum cascade laser (QCL) (3), wherein the IR radiation is directed onto the sample (2) via a phase modulator (5) and at least one optical element (6), and detecting the IR radiation which is reflected and/or transmitted by the sample (2).
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: June 11, 2019
    Assignee: Baden-Wuerttemberg Stiftung gGmbH
    Inventor: Niels Kroeger-Lui
  • Patent number: 10302932
    Abstract: A microscope system (1) includes a microscope and a camera (3) for generating and recording image-based information on an area of observation. A storage and evaluation unit (4) is connected to the microscope (2) and the camera (3) for detecting parameter settings of the microscope associated with the image-based information. A display (5) renders visible the digital image of the area of observation, and a control unit (6) is connected to the storage and evaluation unit (4) and to the display (5). The control unit (6) places digital markers for marking observed objects in a digital image of the area of observation and displays the digital markers on the display (5). The storage and evaluation unit (4) selects and stores information on each digital marker so that the marker can be associated at a later point in time with the position of the observed object.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: May 28, 2019
    Assignee: CARL ZEISS MEDITEC AG
    Inventors: Stefan Saur, Marco Witzbach
  • Patent number: 10295470
    Abstract: To provide a microspectroscope that can perform a wide range mapping measurement with high sensitivity, at high speed, and with high wavelength resolution. The Raman spectroscope comprises: a unit for linearly irradiating excitation light; a movable stage for a sample; an objective lens for focusing Raman light from the linear irradiation region; an incident slit provided at the imaging position of Raman light; a spectrometer for diffusing the passing light; a CCD detector for detecting Raman spectral image; and a control device for controlling the mapping measurement by synchronizing the movable stage and the CCD detector. The control device controls the movable stage to move in the direction orthogonal to the longitudinal direction of the linear irradiation light and obtain one average spectrum.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 21, 2019
    Assignee: JASCO Corporation
    Inventors: Kento Aizawa, Tsutomu Inoue, Masateru Usuki
  • Patent number: 10279742
    Abstract: An image capture device is mounted in a vehicle. The image capture device includes: an image capture unit; and a setting unit that sets an image capture condition for each region of the image capture unit each having a plurality of pixels, or for each pixel, based upon at least one of a state exterior to the vehicle and a state of the vehicle.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: May 7, 2019
    Assignee: NIKON CORPORATION
    Inventors: Akiko Shiga, Toru Miyakoshi, Satoshi Yamaguchi, Akira Kinoshita, Kaoru Yoshino, Hitomi Naganuma, Takashi Kuriyama, Koichi Fukuda, Yuki Kita, Koji Nagaoka, Tomoya Nakagawa, Masakazu Sekiguchi, Takashi Shionoya
  • Patent number: 10276388
    Abstract: A laser processing apparatus 1 is an apparatus for forming a modified region R in an object to be processed S by irradiating the object S with laser light L. The laser processing apparatus 1 comprises a laser light source 2 that emits the laser light L, a mount table 8 that supports the object S, and an optical system 11 that converges a ring part surrounding a center part including an optical axis of the laser light L in the laser light L emitted from the laser light source 2 at a predetermined part of the object S supported by the mount table 8. The optical system 11 adjusts a form of at least one of inner and outer edges of the ring part of the laser light L according to a position of the predetermined part in the object S.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: April 30, 2019
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Tsubasa Hirose, Yuu Takiguchi, Yasunori Igasaki, Hideki Shimoi
  • Patent number: 10274713
    Abstract: A microscope includes a stage on which a specimen is configured to be placed, an epi-illumination optical system having a fluorescence illumination light source configured to irradiate the specimen with excitation light of a predetermined wavelength, a transmitted-light illumination optical system, and a light shielding member. The transmitted-light illumination optical system includes a transmitted-light illumination light source having a white LED, and a condenser having a condenser lens configured to collect light emitted from the transmitted-light illumination light source onto the specimen and configured to move in a direction orthogonal to an illumination optical path so as to be insertable onto and removable from the illumination optical path.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: April 30, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Shintaro Kobayashi, Hironori Utsugi, Minoru Hanaoka
  • Patent number: 10273521
    Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 30, 2019
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
  • Patent number: 10269103
    Abstract: An image processing apparatus comprises a selection unit for selecting at least one pair of two layer image data items having focus positions shifted oppositely, by equal distances, in a positive direction and a negative direction relative to a reference depth in a specimen from among a plurality of layer image data items acquired with the focus positions set at different depths in the specimen and a phase contrast correction unit for performing, for each of the pair of the two layer image data items selected by the selection unit, a correction process which reduces a difference in phase contrast component between the two layer image data items.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: April 23, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Tomohiko Takayama
  • Patent number: 10261307
    Abstract: Provided is a microscope system including: a stage on which a sample is placed and that is movable in a direction orthogonal to an observation optical axis; a detecting unit that detects a position of the stage; an imaging unit that acquires an image of the sample on the stage; an image generating unit that generates an overlapped image by overlapping the acquired image with the position of the stage; a searching unit that searches for a position of the acquired image in the generated overlapped image; and a control unit that performs control including causing the image generating unit to stop the overlapping process and causing the searching unit to execute the position search when detection by the detecting unit fails, and causing the image generating unit to resume the overlapping process starting from a search position of the searching unit when the search is successful.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: April 16, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Masayuki Nakatsuka
  • Patent number: 10254523
    Abstract: A self contained, portable high resolution microscope featuring a flat base 1 to provide a stable optical platform capable of resolving parallel lines 10 ?m apart. The microscope folds or collapses to a flat shape in order to make it very portable.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: April 9, 2019
    Assignee: IOLIGHT LIMITED
    Inventors: Andrew Monk, Richard Williams
  • Patent number: 10241317
    Abstract: An apparatus comprises a unit that manages, state information including information indicating whether the acquisition of partial image data is completed; a acquiring unit that acquires, for each of stitching places of the partial image data, a correction amount for correcting local deviation among the partial image data to be stitched; and a unit that corrects each of the partial image data on the basis of the correction amount, and generating combined image data obtained by stitching the partial image data after the correction. The acquiring unit is controlled on the basis of the state information to start processing for acquiring the correction amount from the partial image data or the stitching place for which acquisition of data necessary for acquiring the correction amount is completed.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: March 26, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Toru Sasaki
  • Patent number: 10229812
    Abstract: An inspection method uses a charged particle microscope to observe a sample and view a defect site or a circuit pattern. A plurality of images is detected by a plurality of detectors and a mixed image is generated by automatically adjusting and mixing weighting factors required when the plurality of images are synthesized with each other. The sample is irradiated and scanned with a charged particle beam so that the plurality of detectors arranged at different positions from the sample detects a secondary electron or a reflected electron generated from the sample. The mixed image is generated by mixing the plurality of images of the sample with each other for each of the plurality of detectors, which are obtained by causing each of the plurality of detectors arranged at the different positions to detect the secondary electron or the reflected electron. The generated mixed image is displayed on a screen.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 12, 2019
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Minoru Harada, Yuji Takagi, Takehiro Hirai
  • Patent number: 10217011
    Abstract: The present invention includes an apparatus and method that facilitates the manual sorting of slides into slide folders. The apparatus includes a horizontal display surface and a controller configured to receive slides and folders into which the slides are to be placed (or sorted). The controller operates components of the apparatus to selectively illuminate the display surface to guide a user in placing folders at multiple folder locations and in sorting the slides into the folders. In one aspect of the invention, the apparatus is configured to allow multiple folders to be stacked at a folder location during the slide sorting process. In these aspects, the apparatus is configured to determine number of folders stacked at each folder location.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: February 26, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Richard K. Workman, Victor Lim, Varun Raghunathan
  • Patent number: 10215563
    Abstract: The invention relates to a surveying instrument comprising a telescope, at least one camera providing first, second or more image signals and a controller, wherein the controller is adapted to combine the image signal data of the first, second or more image signals in order to simultaneously display at least two of the images corresponding to the first, second or more image signals on display means.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 26, 2019
    Assignee: LEICA GEOSYSTEMS AG
    Inventors: Werner Leinhart, Hans-Martin Zogg, Norbert Kotzur, Daniel Nindl
  • Patent number: 10209226
    Abstract: A photoacoustic microscope apparatus includes a light source that emits excitation light which generates photoacoustic waves, an objective lens which focuses the excitation light on a specimen, a scanning unit which moves a focused position of the excitation light on the specimen, a photoacoustic-wave detecting unit which has a sensor unit that detects a photoacoustic wave generated, and an image constructing unit which constructs an image based on data from the photoacoustic-wave detecting unit. For the sensor unit, an angle of a range which is capable of receiving the photoacoustic wave incident on the sensor unit is larger than an angle corresponding to a numerical aperture on a side illuminated of the objective lens.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: February 19, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Ikutoshi Fukushima