Microscope Patents (Class 348/79)
  • Patent number: 12259540
    Abstract: Provided is an image acquisition device including: a stage on which a slide is mounted; an objective lens disposed to face a sample; a beam split unit separating light from the sample, which is incident through the objective lens into at least two, and delivering the separated lights; at least two image sensor units acquiring an image of the sample from the lights separated by the beam split unit; an image generation unit synthesizing the image acquired from the image sensor unit and generating the synthesized image; and a main control unit controlling operations of the stage or the objective lens, and the image sensor unit and the image generation unit, in which the stage is movable relatively to an optical axis of the objective lens at least in a first direction, and the at least two image sensor units acquire images at different focus positions for the sample.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: March 25, 2025
    Assignee: Vieworks Co., Ltd.
    Inventors: Mingyu Jin, Yu Jung Kang, Chang Woo Kang, Kyoung Ryoul Seo
  • Patent number: 12248533
    Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: March 11, 2025
    Assignee: Essenlix Corporation
    Inventors: Xing Li, Wu Chou, Stephen Y. Chou, Wei Ding, Ji Qi
  • Patent number: 12235432
    Abstract: Provision is made for a method of monitoring an immersion fluid in a microscope having a lens which images a sample located on a sample carrier. In a step a), a camera is positioned which has an image field which is oriented in such a way that it captures the sample carrier and a space between the sample carrier and the lens and adjoining the sample carrier towards the lens, which space is used to receive the immersion fluid. In a step b), the immersion fluid is applied into the space between the sample carrier and the lens. In step c), an image with the immersion fluid being in the space between the sample carrier and the lens is recorded, and in a step d), the position, the area and/or the contour of the immersion fluid on the sample carrier from the image recorded in step d) are/is determined.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: February 25, 2025
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Thomas Ohrt, Daniel Haase
  • Patent number: 12228723
    Abstract: Described herein are systems and methods for assessing a biological sample. The methods include: characterizing a speckled pattern to be applied by a diffuser; positioning a biological sample relative to at least one coherent light source such that at least one coherent light source illuminates the biological sample; diffusing light produced by the at least one coherent light source; capturing a plurality of illuminated images with the embedded speckle pattern of the biological sample based on the diffused light; iteratively reconstructing the plurality of speckled illuminated images of the biological sample to recover an image stack of reconstructed images; stitching together each image in the image stack to create a whole slide image, wherein each image of the image stack at least partially overlaps with a neighboring image; and identifying one or more features of the biological sample. The methods may be performed by a near-field Fourier Ptychographic system.
    Type: Grant
    Filed: February 6, 2024
    Date of Patent: February 18, 2025
    Assignee: Pathware Inc.
    Inventors: Rodger Michael Moore, Cordero Derrell Core, Jaron Nathaniel Nix, Thomas Karl, Samatha Hastings, Samir Yhann
  • Patent number: 12228716
    Abstract: A microscope includes: a motorized object stage for moving an object; an optical imaging system for forming an optical image of a plane (OE) in which the object is to be optically imaged; an optical scanning unit for moving the plane (OE) to be optically imaged by the optical imaging system relative to the optical imaging system; an image sensor for detecting the optical image of the plane (OE) formed by the optical imaging system; and a controller for controlling the motorized object stage and the optical scanning unit for simultaneously moving the object and the plane (OE) in a same direction relative to the optical imaging system while the optical image is being detected by the image sensor.
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: February 18, 2025
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Christian Schumann
  • Patent number: 12211241
    Abstract: A method of imaging comprises: generating a superoscillatory field from coherent electromagnetic radiation; placing an object in the superoscillatory field; detecting one or more intensity distributions of the superoscillatory field scattered by the object; and determining at least one characteristic of the object from the one or more intensity distributions.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: January 28, 2025
    Assignees: University of Southampton, Nanyang Technological University
    Inventors: Nikolay Ivanovich Zheludev, Guanghui Yuan, Nikitas Papasimakis, Vassily Savinov
  • Patent number: 12211186
    Abstract: A video processing apparatus includes: an acquisition unit configured to acquire subject eye video data; an elimination unit configured to eliminate positional offset resulting from involuntary eye movement from the subject eye video data on the basis of the subject eye video data acquired by the acquisition unit; an emphasis unit configured to perform emphasis on the subject eye video data that was subjected to the elimination performed by the elimination unit; and an output unit configured to output the subject eye video data that was subjected to the emphasis by the emphasis unit.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: January 28, 2025
    Assignee: NIKON CORPORATION
    Inventor: Mariko Mukai
  • Patent number: 12181652
    Abstract: A method for image generation by means of a microscope includes: locating a sample to be imaged in an object space of the microscope for the image generation using specified image generation parameters; firstly detecting a movement or an intended movement of the sample; and thereupon automatically changing at least one image generation parameter during the movement of the sample depending on a movement variable.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: December 31, 2024
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Patric Pelzer
  • Patent number: 12146822
    Abstract: Provided is a particle quantitative measurement device according to which the number of particles that can be accurately recognized in a particulate sample has a wider range. An observation device 1 comprises a computer 108 and an imaging camera 107 for acquiring a sample image representing the particulate sample. As an extraction unit, the computer 108 extracts a low-brightness pixel for which I<M?k? is satisfied for brightness I from pixels of the sample image. Here, M represents brightness for a reference image, k represents a real positive number, and ? represents a standard deviation for the brightnesses of the pixels in the reference image. The computer 108 also functions as a particle recognition unit or a particle quantitative measurement unit and quantitatively measures the particulate sample on the basis of the low-brightness pixel.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: November 19, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Noriko Ebine, Satoshi Takahashi, Akira Masuya
  • Patent number: 12147022
    Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.
    Type: Grant
    Filed: June 2, 2023
    Date of Patent: November 19, 2024
    Assignee: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Celalettin Yurdakul, Haonan Zong, M. Selim Ünlü
  • Patent number: 12130418
    Abstract: A microscope system includes an eyepiece, an objective, a tube lens, an imaging apparatus, a projection apparatus that projects a projection image onto an image plane between the tube lens and the eyepiece on which an optical image is formed, and a control apparatus. The control apparatus manages microscope information including at least a first magnification at which an image of the sample is projected onto the image plane, a second magnification at which an image of the sample is projected onto the imaging apparatus, a third magnification at which an image of the projection apparatus is projected onto the image plane, and sizes of the imaging apparatus and the projection apparatus. The control apparatus includes a processor. The processor generates projection image data representing the projection image based on at least the microscope information.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: October 29, 2024
    Assignee: Evident Corporation
    Inventors: Tatsuo Nakata, Hiroshi Sasaki, Tetsuya Shirota
  • Patent number: 12133005
    Abstract: One example system comprises a LIDAR sensor that rotates about an axis to scan an environment of the LIDAR sensor. The system also comprises one or more cameras that detect external light originating from one or more external light sources. The one or more cameras together provide a plurality of rows of sensing elements. The rows of sensing elements are aligned with the axis of rotation of the LIDAR sensor. The system also comprises a controller that operates the one or more cameras to obtain a sequence of image pixel rows. A first image pixel row in the sequence is indicative of external light detected by a first row of sensing elements during a first exposure time period. A second image pixel row in the sequence is indicative of external light detected by a second row of sensing elements during a second exposure time period.
    Type: Grant
    Filed: January 5, 2023
    Date of Patent: October 29, 2024
    Assignee: Waymo LLC
    Inventors: Blaise Gassend, Benjamin Ingram, Andreas Wendel, Mark Alexander Shand
  • Patent number: 12123868
    Abstract: An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: October 22, 2024
    Assignee: Alentic Microscience Inc.
    Inventor: Alan Marc Fine
  • Patent number: 12121301
    Abstract: The present invention relates to an apparatus for inspecting the ocular fundus that comprises: —an illuminator (1) adapted to provide an illuminating light beam (IL) to illuminate a portion of said biological tissue, said illuminating beam being shaped so that at least a portion of said illuminating beam has a line-shaped section; —one or more lenses (2, 4, 7) to focus said illuminating beam (IL) on said biological tissue, during operation of said apparatus said illuminating beam illuminating a line-shaped region (5B) of said biological tissue; —a scanning assembly (3) adapted to perform optical scans of said biological tissue by cyclically moving the illuminating beam (IL) projected by said illuminator on said biological tissue, along a scanning direction (DS) substantially perpendicular to a main extension direction (AE) of the region (5B) of biological tissue illuminated by said illuminating beam; —acquisition means (6) adapted to receive reflected light (R) from said biological tissue to acquire images of
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 22, 2024
    Assignee: Center Vue S.p.A.
    Inventors: Andrei Plaian, Federico Manzan, Marco D'Aguanno, Irene Mogentale
  • Patent number: 12095980
    Abstract: Systems and methods for automated, non-supervised, parameter-free segmentation of single cells and other objects in images generated by fluorescence microscopy. The systems and methods relate to both improving initial image quality and to improved automatic segmentation on images. The methods will typically be performed on a digital image by a computer or processor running appropriate software stored in a memory.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: September 17, 2024
    Assignee: Canopy Biosciences, LLC
    Inventor: Christian Hennig
  • Patent number: 12078792
    Abstract: A method of providing an assembled image using a digital microscope, the digital microscope having an optical system, an image sensor having a predefined number of image pixels, and a stage, the stage being movable in relation to the optical system and the image sensor, includes receiving a user selection regarding an area of interest of the sample, the user selection indicating the position and extension of the area of interest, selecting one of a full resolution mode or and a reduced resolution mode, wherein individual images with a reduced number of image pixels are generated, moving the stage with respect to the optical system and the image sensor, and generating individual images of the area of interest in accordance with the selected one of the full resolution mode or the reduced resolution mode, and combining the individual images into the assembled image, representing the area of interest.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: September 3, 2024
    Assignee: PreciPoint GmbH
    Inventors: Ludwig Wildner, Andreas Schmid
  • Patent number: 12063430
    Abstract: An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: August 13, 2024
    Assignee: ILLUMINA, INC.
    Inventors: Steven Boege, Simon Prince, Peter Newman, Matthew Hage, Geraint Evans
  • Patent number: 12044626
    Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: July 23, 2024
    Assignee: ILLUMINA, INC.
    Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
  • Patent number: 12025788
    Abstract: An imaging device includes an alignment platform configured to hold a cell culture plate having a plurality of wells and an imaging assembly including a plurality of imaging units, each of which is configured to image one well of the plurality of wells.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: July 2, 2024
    Assignee: The Regents of the University of California
    Inventors: Victoria Ly, Pierre Baudin, Yohei Rosen, Pattawong Pansodtee, Kateryna Voitiuk, David Haussler, Mircea Teodorescu
  • Patent number: 12028606
    Abstract: A system for remotely controlling microscopic machinery and a method thereof are provided. The system includes at least one local device and a remote host for sending a control command thereto. A microslide is placed on a microscopic camera device in the local device, and the microscopic camera device captures an image of the microslide according to a capture command in the control command. The local device transmits the image to the remote host in a video format. A motorized stage moves to a next preset position according to a movement command in the control command to capture another image of the microslide. The steps of capturing and transmitting the image and the step of moving are repeated until the microslide is captured completely. The invention can solve the problem of time delay when the image captured by the remote control microscopic camera device is displayed.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: July 2, 2024
    Assignee: V5MED INC.
    Inventors: Tzu-Kuei Shen, Kuo-Tung Hung, Guang-Hao Suen, Liang-Wei Sheu
  • Patent number: 12019229
    Abstract: A illumination arrangement for a microscope for illuminating a sample with a light sheet includes an illumination input configured to feed an illumination beam along an optical axis of the illumination arrangement and an illumination output which faces a sample side and is configured to output the illumination beam to the sample side. A focusing optical system is provided with a set depth of focus. At least one optical modification element is configured to geometrically modify the illumination beam. Different rays of the illumination beam intersect the optical axis within an axis intersection region at the illumination output. The axis intersection region extends over at least the depth of focus of the focusing optical system along the optical axis.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 25, 2024
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Florian Fahrbach
  • Patent number: 12016690
    Abstract: Disclosed herein is a platform and method to quantify spatiotemporal tissue swelling during biologics injection, and to predict associated increase in the mechanical stress and interstitial fluid pressure (IFP) of tissues. Accurate measure and estimation of tissue swelling, thus, can be quantitative and predictive indicator of the IPD.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: June 25, 2024
    Assignee: Purdue Research Foundation
    Inventors: Bumsoo Han, Yingnan Shen
  • Patent number: 12007548
    Abstract: A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: June 11, 2024
    Assignee: Optofluidics, Inc.
    Inventors: Colby Ashcroft, Brian DiPaolo, Gjergji Konica, Thomas Castner, Bernardo Cordovez, Christopher Earhart, David Erickson, Robert Hart
  • Patent number: 12003841
    Abstract: Embodiments described herein relate to an inspection system for illumination of optical devices. The inspection system includes a stage, a focusing lens, a light source, a reflective surface, and a camera. The inspection system is operable to provide a light to a substrate. The substrate is positioned on the inspection system such that an edge of the substrate is exposed. The inspection system focuses light to the edge such that the light propagates through the substrate. The light is coupled out of the substrate, illuminating one or more optical devices disposed on the substrate. The illumination allows the camera to capture images to be inspected. The images are inspected to detect defects of the substrate.
    Type: Grant
    Filed: May 4, 2022
    Date of Patent: June 4, 2024
    Assignee: Applied Materials, Inc.
    Inventors: Michael David-Scott Kemp, Jinxin Fu
  • Patent number: 11988584
    Abstract: A disposable staining system is provided including an insertable module configured to receive a biological sample therein, the insertable module including a well in which the biological sample is positioned; and a staining cartridge configured to receive the insertable module including the biological sample therein, the insertable module being positioned in the staining cartridge. The insertable module has first and second inclined planes on opposing sides of an upper surface of the insertable module. A sled configured to receive the insertable module has corresponding first and second inclined planes on a bottom surface thereof. The first and second inclined planes of the insertable module and the first and second inclined planes of the sled are configured to transform horizontal movement of the insertable module into the staining cartridge into a vertical movement of the sled such that the sled is pushed upward.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 21, 2024
    Assignee: Instapath, Inc.
    Inventors: Samuel Jacob Luethy, Jonathon Quincy Brown, David Benjamin Tulman, Andrew Blake Sholl, Peter Joseph Lawson, Mei Wang
  • Patent number: 11988824
    Abstract: The present invention concerns a method for producing a microscopic image with an extended depth of field by means of a microscope. The microscope comprises an images sensor that comprises pixels that are arranged as a matrix that is formed by lines. In a step of the method, a plurality of microscopic frames of a specimen is acquired while a focus position (z) is changed. The microscopic frames are acquired line by line. The focus position (z) is changed over a course of acquiring individuals of the microscopic frames. In a further step, parts of individuals of the acquired lines are identified. These parts sharply image the specimen. The identified parts of the lines are composed in order to form a microscopic image of the specimen with an extended depth of field. Furthermore, the present invention concerns a microscope.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: May 21, 2024
    Assignees: Carl Zeiss Microscopy GmbH, SD Optics, Inc., Stereo Display, Inc.
    Inventors: Alexander Gaiduk, Ilja Karanin, Pavlos Iliopoulos, Jin Young Sohn, Gyoungil Cho, Cheong Soo Seo
  • Patent number: 11971532
    Abstract: A microlens array-based ultrathin microscope is provided. The microlens array-based ultrathin microscope includes a filter unit configured to selectively transmit fluorescence manifested in a measurement sample, and an image unit configured to acquire an image from light transmitted by the filter unit. The filter unit is formed to be in contact with or spaced apart from one surface of a transparent substrate, and the image unit includes a microlens array formed on an opposite surface to the transparent substrate in which the filter unit is formed, and an image sensor configured to collect image information of the microlens array.
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: April 30, 2024
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ki-Hun Jeong, Kyung-Won Jang, Byounghoon Kang, Younggil Cha
  • Patent number: 11954831
    Abstract: A method of image evaluation when performing SIM microscopy on a sample includes: A) providing n raw images of the sample, which were each generated by illuminating the sample with an individually positioned SIM illumination pattern and imaging the sample in accordance with a point spread function, B) providing (S1) n illumination pattern functions, which each describe one of the individually positioned SIM illumination patterns, C) providing (S1) the point spread function and D) Carrying out an iteration method, which includes following iteration steps a) to e), as follows: a) providing an estimated image of the sample, b) generating simulated raw images, in each case by image processing of the estimated image using the point spread function and one of the n illumination pattern functions such that n simulated raw images are obtained, c) assigning each of the n simulated raw images to that of the n provided raw images which was generated by the illumination pattern that corresponds to the illumination patter
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: April 9, 2024
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Ingo Kleppe, Yauheni Novikau, Lutz Schaefer
  • Patent number: 11947099
    Abstract: Aspects of present disclosure relate to real-time image generation. An exemplary apparatus for real time image generation includes at least an optical system, a slide port configured to hold a slide, an actuator mechanism mechanically connected to a mobile element, a user interface comprising an input interface and an output interface, at least processor configured to: using the at least an optical system, capture a first image of the slide at a first position, modify the first image, using the output interface, display the first image to a user, using the input interface, receive a parameter set from the user.
    Type: Grant
    Filed: July 25, 2023
    Date of Patent: April 2, 2024
    Inventors: Ganesh Ramamoorthy, Prasanth Perugupalli
  • Patent number: 11937986
    Abstract: A method for acquiring annotated data with the aid of surgical microscopy systems comprises obtaining desired criteria which are intended to be satisfied by desired data to be annotated, and storing the set of desired criteria in a plurality of surgical microscopy systems. In each surgical microscopy system, images are then recorded and current criteria which correspond to the recorded images are determined. The current criteria are compared with the desired criteria. If the desired criteria sufficiently correspond to the current criteria, a confirmation is requested from a user as to whether said user would like to annotate data. If the user provides the confirmation, annotations for images are received from the user and stored together with the images.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: March 26, 2024
    Assignee: Carl Zeiss Meditec AG
    Inventor: Stefan Saur
  • Patent number: 11927737
    Abstract: The disclosure may relate to a method for the characterization of the 3D orientation of an emitting dipole within a specimen. The method comprises splitting a light beam emitted by the emitting dipole and exiting an objective lens into a first and a second beams; spatially filtering said first beam by using a spatial frequency filter; splitting each of said filtered first beam and said second beam into two beams linearly polarized using polarizing beam splitters; detecting with an optical detection unit four beams linearly polarized in a detection plane optically conjugated with the front focal plane of said microscope objective lens; determining, from four intensity images, in a predefined frame of the specimen, the mean orientation and the angular aperture of the distribution of the 3D orientation of the emitting dipole, during an acquisition time of said four intensity images.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 12, 2024
    Assignees: Université d'Aix-Marseille, Centre National de la Recherche Scientifique, CENTRALE MARSEILLE
    Inventors: Sophie Brasselet, Valentina Curcio
  • Patent number: 11927738
    Abstract: Described herein are systems and methods for assessing a biological sample. The methods include: characterizing a speckled pattern to be applied by a diffuser; positioning a biological sample relative to at least one coherent light source such that at least one coherent light source illuminates the biological sample; diffusing light produced by the at least one coherent light source; capturing a plurality of illuminated images with the embedded speckle pattern of the biological sample based on the diffused light; iteratively reconstructing the plurality of speckled illuminated images of the biological sample to recover an image stack of reconstructed images; stitching together each image in the image stack to create a whole slide image, wherein each image of the image stack at least partially overlaps with a neighboring image; and identifying one or more features of the biological sample. The methods may be performed by a near-field Fourier Ptychographic system.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: March 12, 2024
    Assignee: Pathware Inc.
    Inventors: Rodger Michael Moore, Cordero Derrell Core, Jaron Nathaniel Nix, Thomas Karl, Samantha Hastings, Samir Yhann
  • Patent number: 11921023
    Abstract: Holographic Video Microscopy analysis of non-spherical particles is disclosed herein. Properties of the particles are determined by application of light scattering theory to holography data. Effective sphere theory is applied to provide information regarding the reflective index of a sphere that includes a target particle. Known particles may be co-dispersed with unknown particles in a medium and the holographic video microscopy is used to determine properties, such as porosity, of the unknown particles.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: March 5, 2024
    Assignees: New York University, Spheryx, Inc.
    Inventors: David G. Grier, Mary Ann Odete, Fook Chiong Cheong, Annemarie Winters, Jesse J. Elliott, Laura A. Philips
  • Patent number: 11915094
    Abstract: A sample analysis system and a sample management method are provided. The sample analysis system includes: one or more analysis devices configured to test a sample; a scanning component configured to scan the sample to obtain scanning information before testing the sample by the analysis devices; an image information obtaining component configured to acquire image information of a region in the sample containing a sample identifier; a processor configured to identify the sample identifier of the sample according to at least one of the scanning information or the image information of the sample. The system can obtain the sample identifier of a sample in two ways, thus improving the efficiency of sample test.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: February 27, 2024
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Xinyuan Huang, Fanshun Zeng
  • Patent number: 11914134
    Abstract: A microscope system for imaging at least one region of a sample includes: an image generating unit for microscopic imaging of a section of a sample region to be imaged acquired in an observation beam path; a movement unit for moving the section to be imaged into the observation beam path of the image generating unit; a graphic user interface displayed on a display for establishing a movement range corresponding to the sample region to be imaged by way of at least one user input, the graphic user interface displaying a coordinate system and, after input of at least one point in the displayed coordinate system, the movement range is established as a defined movement volume; and a control unit for activating the movement unit as a function of the defined movement volume so as to approach a set of sections corresponding to the defined movement volume in succession.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 27, 2024
    Assignees: LEICA MICROSYSTEMS CMS GMBH, LEICA INSTRUMENTS (SINGAPORE) PTE. LTD.
    Inventors: Stefan Fabris, Jozsef Attila Gombos
  • Patent number: 11906431
    Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: February 20, 2024
    Assignee: NIKON CORPORATION
    Inventors: Ichiro Sase, Yasutoshi Kaneko, Tatsuo Fukui
  • Patent number: 11900574
    Abstract: The image processing system includes a scanner, a pixelated photon detector (PPD), and at least one processor. The at least one processor displays a setting screen on a display unit. The setting screen is a screen for setting an identification range that is a range of gradation to be identified. The at least one processor displays a second image obtained by converting a first image on the display unit. The second image is an image obtained by converting the first image based on at least the identification range. The first image is generated based on an intensity signal of light detected by a PPD and a scanning position by the scanner.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: February 13, 2024
    Assignee: Evident Corporation
    Inventors: Kanako Isono, Hirokazu Kubo
  • Patent number: 11885947
    Abstract: A lattice light sheet microscope includes a single spatial light modulator (SLM), the optical modulation plane of which conjugates to an image plane of an excitation objective and which is configured to: generate an optical lattice by loading a phase map obtained from a central cross section of a corresponding optical lattice of a desired lattice light sheet, and tile the optical lattice by loading a phase map obtained from an off-center cross section of the corresponding optical lattice. The lattice light sheet microscope also includes a transparent annular diaphragm arranged at a plane conjugating to the entrance pupil of the excitation objective lens. The lattice light sheet microscope further includes a first galvanometer configured to: scan each optical lattice in the extending direction thereof so as to form a tiled lattice light sheet.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: January 30, 2024
    Assignee: Westlake University
    Inventors: Liang Gao, Bi-Chang Chen
  • Patent number: 11887327
    Abstract: A microscopic examination device includes: a camera that images an observation area of an examination subject observed with a microscope device so as to acquire an image of the observation area; and one or more processors including hardware, the one or more processors being configured to: align the image of the observation area with an area in a reference image, the area corresponding to the image of the observation area; generate a navigation map from the reference image by recording, on the reference image, a position of the image of the observation area in the reference image; calculate a direction of movement to an unobserved area in the navigation map, the unobserved area being an area where the position of the image of the observation area is not recorded; and present an access method to the unobserved area on a basis of the direction of movement.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: January 30, 2024
    Assignee: Evident Corporation
    Inventor: Yoko Abe
  • Patent number: 11864841
    Abstract: A method of operating a surgical microscope includes receiving an instruction to move the camera relative to the object, operating a zoom lens to zoom out and displaying images obtained by processing images recorded by the camera such that centers of the displayed images correspond to a target position within the recorded images and such that the magnification of the object displayed in the images is the initial magnification, wherein the target position is displaced within the recorded images relative to the first position, and operating actuators to move the camera.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: January 9, 2024
    Assignee: Carl Zeiss Meditec AG
    Inventors: Fang You, David Dobbelstein, Stefan Saur
  • Patent number: 11861889
    Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: January 2, 2024
    Assignees: The University of Tokyo, Osaka University
    Inventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
  • Patent number: 11835509
    Abstract: A specimen analysis apparatus includes: a light source; an imager configured to capture, at predetermined time intervals, images of the specimen and sequentially generate image data; a processor configured to sequentially detect the core tissue that appears in an image corresponding to the sequentially generated image data, sequentially calculate a tissue amount of the core tissue based on the sequentially detected core tissue, and determine whether the tissue amount of the core tissue is smaller than a threshold value set in advance every time the processor calculates the tissue amount; an isolator configured to isolate the core tissue from the specimen; and a drive controller configured to cause the isolator to perform the isolation operation when the tissue amount is smaller than the threshold value, and cause the isolator to stop the isolation operation when the tissue amount is equal to or larger than the threshold value.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: December 5, 2023
    Assignee: Evident Corporation
    Inventor: Ken Ioka
  • Patent number: 11836948
    Abstract: An image calibration method applied to an image calibration device includes comparing a first image with a second image to acquire a first overlapping region of the first image and a second overlapping region of the second image, analyzing color distribution of the first overlapping region to acquire at least one first base color value, analyzing color distribution of the second overlapping region to acquire at least one second base color value, setting a ratio of the at least one first base color value to the at least one second base color value as an luminance compensation value when the at least one first base color value is greater than the at least one second base color value, and utilizing the luminance compensation value to adjust pixels of the second image. The first overlapping region is overlapped with the second overlapping region.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: December 5, 2023
    Assignee: VIVOTEK INC.
    Inventors: Chung-Yi Kao, Shih-Hsuan Chen
  • Patent number: 11788885
    Abstract: A test apparatus includes: an electrical connection unit electrically connected to a terminal of each of a plurality of light emitting devices to be tested; a light source unit for collectively irradiating the plurality of light emitting devices with light; an electrical measurement unit for measuring a photoelectric signal obtained by photoelectrically converting the light irradiated from the light source unit by each light emitting device; a light emission control unit for causing at least one light emitting device to be subjected to light emission processing to emit light; a light measuring unit for measuring light emitted by the at least one light emitting device to be subjected to the light emission processing; and a determination unit determining a quality of each light emitting device on the basis of a measurement result of the electrical measurement unit and a measurement result of the light measuring unit.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: October 17, 2023
    Assignee: ADVANTEST CORPORATION
    Inventors: Kotaro Hasegawa, Kouji Miyauchi, Go Utamaru
  • Patent number: 11721035
    Abstract: The present invention discloses a system and method for improvement in process of measurement of body circumference using Augmented Reality (AR) and 4-point mathematical calculations approach and mobile device camera. The method includes the steps of receiving two or more individual parameters from an individual device; receiving at least one set of 4 points capture through AR technology; measurement through AR technology from the individual device, at least one dimension including user's inputs on height, weight, age, and size range; performing body segmentation on at least one dimensions to identify one or more body features associated with the human from the background; performing the distance calculation between four points; compare the calculation results with standard sizing database and displaying the final output to the individual.
    Type: Grant
    Filed: June 5, 2021
    Date of Patent: August 8, 2023
    Assignee: TAILORU LLC
    Inventor: Thu Minh Do
  • Patent number: 11699081
    Abstract: The disclosed computer-implemented method may include (1) receiving, at a hardware accelerator that supports an ANN, an activation data set that is to undergo a convolution operation via a filter kernel of the ANN, (2) receiving, at the hardware accelerator, an argument indicating that the filter kernel exceeds at least one boundary of the activation data set when slid across a certain position during the convolution operation, (3) determining, based at least in part on the argument, that the hardware accelerator is to generate padding data at the boundary of the activation data set in connection with the certain position of the filter kernel, and then (4) performing, at the hardware accelerator, the convolution operation by processing a portion of the activation data set and the padding data when the filter kernel slides across the certain position. Various other systems and methods are also disclosed.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 11, 2023
    Assignee: Meta Platforms, Inc.
    Inventors: Ehsan Khish Ardestani Zadeh, Martin Schatz, Krishnakumar Narayanan Nair, Yuchen Hao, Abdulkadir Utku Diril, Rakesh Komuravelli
  • Patent number: 11686933
    Abstract: An imaging system includes a sample mount for holding a sample to be imaged, a light source configured to emit a light beam to be incident on the sample, a translation mechanism coupled to the sample mount and configured to scan the sample to a plurality of sample positions in a plane substantially perpendicular to an optical axis of the imaging system, a mask positioned downstream from the sample along the optical axis, and an image sensor positioned downstream from the mask along the optical axis. The image sensor is configured to acquire a plurality of images as the sample is translated to the plurality of sample positions. Each respective image corresponds to a respective sample position. The imaging system further includes a processor configured to process the plurality of images to recover a complex profile of the sample based on positional shifts extracted from the plurality of images.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: June 27, 2023
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 11675490
    Abstract: A management system for managing setting information of an observation system includes: one or more non-transitory computer-readable media that include an instruction; and one or more processors that execute the instruction. The instruction is configured to cause the one or more processors to perform an operation. The operation includes detecting a use status of a setting indicated by the setting information, and updating, in accordance with the detected use status, evaluation information indicating an evaluation pertaining to the setting, the evaluation information being managed so as to be associated with the setting information.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: June 13, 2023
    Assignee: Evident Corporation
    Inventor: Naohiro Ariga
  • Patent number: 11674877
    Abstract: Method of and apparatus for performing cyclic flow cytometry analysis on a sample population of cellular entities including: causing each cellular entity to be labeled with an optical identifier; for each cellular entity, performing a first pass of flow cytometry measurement over a flow channel with respect to a first set of parameters, under conditions of determining an identification for the cellular entity for which values of the first set of parameters are being obtained, and storing the values of the first set in association with the identification; and performing a second pass of flow cytometry measurement over the flow channel with respect to a second set of parameters, under conditions of separately determining an identification for the cellular entity for which values of the second set of parameters are being obtained, and storing the values of the second set in association with the identification.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: June 13, 2023
    Assignee: LASE Innovation Inc.
    Inventors: Sheldon J. J. Kwok, Han Zhu
  • Patent number: 11656446
    Abstract: Disclosed herein is a method of acquiring a high-resolution scan of a biological sample disposed on a substrate with a scanning device, the method comprising: receiving, on a graphical user interface, a first user input corresponding to user configurable scanning settings; receiving, on a graphical user interface, a second user input to initiate scanning based on the received series of user inputs corresponding to user configurable scanning settings; and displaying, on the graphical user interface, a visualization of one or more placeholders populated with one or more of scanning operation status information, image data, and at least a portion of the user configurable scanning settings.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 23, 2023
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Maya D'Costa, Daniela Pretorius, Pedro De Sousa Couto E Santos