Microscope Patents (Class 348/79)
  • Patent number: 11169089
    Abstract: A measurement chip including a prism, a metal film, and a capturing body is prepared. In a state in which a specimen is present on the metal film, scattered light obtained when first light which passes through the metal film and the specimen is scattered in the specimen when the first light is applied to the metal film from a prism side at a first incident angle smaller than a critical angle is detected. In a state in which a substance to be measured is captured by the capturing body and the specimen is not present on the metal film, a signal indicating an amount of the substance to be measured generated in the measurement chip when second light is applied to the metal film at a second incident angle not smaller than the critical angle from the prism side is detected. On the basis of a hematocrit value of the specimen determined from a light amount of the scattered light, a measurement value indicating the amount of the substance to be measured determined from the signal is corrected.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 9, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tetsuya Noda, Fumio Nagai, Youichi Aoki, Makiko Otani
  • Patent number: 11151716
    Abstract: The instant disclosure provides methods of extracting stain-independent features from digital images of histologically stained cells. Stain-independent features provide consistent assessment of cell morphology in the presence of staining variation and across different stains or stain formulations. Improved consistency in cell morphology assessments finds use in automated cell classification and other image processing applications. Also included are systems for practicing the described methods. The instant disclosure also provides computer readable media storing instructions that, when executed by a computing device, cause the computing device and/or components of a described system to perform steps of a method involving of extraction of stain-independent features from digital images.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: October 19, 2021
    Assignee: Abbott Laboratories
    Inventors: Rene Nieves Alicea, Wenjing Li
  • Patent number: 11143606
    Abstract: To enable evaluation of a shape of a fine particle and a fine particle type, a substrate is set as a substrate on which an isolated fine particle to be measured and an isolated standard fine particle in the vicinity of the isolated fine particle to be measured are disposed, and a scanning electron microscope body including a detector configured to detect secondary charged particles obtained by scanning a surface of the substrate with an electron beam probe, and a computer that processes a detection signal and generates an image of the isolated fine particle to be measured and the isolated standard fine particle are provided. The computer corrects a shape of the isolated fine particle to be measured by using a measurement result of the isolated standard fine particle disposed in the vicinity of the isolated fine particle to be measured.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 12, 2021
    Inventors: Tomihiro Hashizume, Masatoshi Yasutake, Tsunenori Nomaguchi, Takafumi Miwa
  • Patent number: 11137339
    Abstract: A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: October 5, 2021
    Assignee: Abbott Laboratories
    Inventors: Richard G. Kendall, John W. Roche
  • Patent number: 11134199
    Abstract: An image pickup apparatus includes an image pickup device, a display device including, in a finder loupe visual field, an image display region and an image display outside region, and a display controller configured to control the display device. The display controller determines a difficulty degree of visibility of a boundary between the image display region and the image display outside region and controls the display device to draw a boundary display when the difficulty degree is equal to or larger than a predetermined value and not to draw the boundary display when the difficulty degree is smaller than the predetermined value.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: September 28, 2021
    Assignee: Olympus Corporation
    Inventors: Hiroki Kudo, Kazuki Sakurai, Hiroki Koyama, Takeshi Suzuki, Keiji Kunishige
  • Patent number: 11125660
    Abstract: The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case, and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 21, 2021
    Inventors: Michael Barnes, Srinivas Chukka, Mohammad Qadri
  • Patent number: 11120968
    Abstract: Aspects of the present disclosure involve applying a Multi-Objective Autonomous Dynamic Sampling algorithm in an electron or other radiation/charged-particle microscope for the characterization of elemental, chemical, and crystallographic information with over an order of magnitude improvement in time and exposure.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: September 14, 2021
    Assignee: Northwestern University
    Inventors: Karl A. Hujsak, Vinayak P. Dravid
  • Patent number: 11112590
    Abstract: Disclosed herein is a smartphone microscope hardware for facilitating diagnosing microscopic objects in a sample of an object, in accordance with some embodiments. Accordingly, the smartphone microscope hardware may include a smartphone case, a magnifier, a glass slide, and a light source. Further, the smartphone case is configured to interface with a smartphone. Further, the magnifier is attached to the smartphone case. Further, the glass slide is configured for receiving the sample. Further, the camera is configurable for capturing an image of the sample. Further, the magnifier is configured for magnifying the image prior to the capturing. Further, a processing device of the smartphone is configurable for analyzing the image, identifying a microscopic object, and generating a notification. Further, a display device of the smartphone is configurable for displaying the image and the notification. Further, the light source is disposed adjacent to a second side of the glass slide.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: September 7, 2021
    Inventor: Adelle Jia Xin Yong
  • Patent number: 11099368
    Abstract: A microscope system and method allow for a desired x?-direction scanning along a specimen to be angularly offset from an x-direction of the XY translation stage, and rotates an image sensor associated with the microscope to place the pixel rows of the image sensor substantially parallel to the desired x?-direction. The angle of offset of the x?-direction relative to the x-direction is determined and the XY translation stage is employed to move the specimen relative to the image sensor to different positions along the desired x?-direction without a substantial shift of the image sensor relative to the specimen in a y?-direction, the y?-direction being orthogonal to the x? direction of the specimen. The movement is based on the angle of offset.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: August 24, 2021
    Assignee: Nanotronics Imaging, Inc.
    Inventors: Matthew C. Putman, John B. Putman, Brandon Scott, Dylan Fashbaugh
  • Patent number: 11077438
    Abstract: The present disclosure relates to an optical apparatus for imaging and/or manipulating micro-objects in a microfluidic device, such as a light-actuated microfluidic (LAMF) device, and related systems and methods. The optical apparatus can comprise a structured light modulator, a first and a second tube lens, an objective lens, a dichroic beam splitter, and an image sensor. The structured light modulator can be configured to receive unstructured light beams and transmit structured light beams for illuminating micro-objects located within an enclosure of the microfluidic device and/or selectively activating one or more of a plurality of dielectrophoresis (DEP) electrodes of the microfluidic device. The first tube lens can be configured to capture the structured light beams transmitted by the structured light modulator. The second tube lens can be configured to transmit image light beams from the dichroic beam splitter to the image sensor.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: August 3, 2021
    Inventors: Paul M. Lundquist, Paul M. Lebel, Phillip Ronald Thomas Jess
  • Patent number: 11079584
    Abstract: A method for use in optical imaging, a system for using in optical imaging, and an optical system includes a controller arranged to determine an intermediate position of a sample upon a detection of a completion of a first movement of the sample, and to derive an optimal position associated with the intermediate position; a manipulator arranged to move the sample from the intermediate position to the optimal position with a second movement; wherein the sample is arranged to be observed using an optical instrument in the optimal position.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: August 3, 2021
    Assignee: City University of Hong Kong
    Inventors: Yajing Shen, Haojian Lu
  • Patent number: 11061214
    Abstract: A cell observation apparatus includes an image formation optical system control unit 51 which sets an initial scanning range of the focal position based on information relating to a thickness of a cell, forms an image of the cell at each of a plurality of focal positions within a set initial scanning range, subsequently acquires an image captured by an imaging unit 40 for each of the plurality of focal positions, estimates the thickness of the cell based on the image, updates the initial scanning range of the focal position based on the estimated thickness of the cell, and forms an image of the cell at each of a plurality of focal positions within the updated scanning range.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: July 13, 2021
    Assignee: FUJIFILM Corporation
    Inventor: Kenta Matsubara
  • Patent number: 11050922
    Abstract: An automatic focusing method and apparatus comprise the following steps: acquiring a target image that has been divided into blocks; acquiring the definition of each block, respectively; acquiring normalized central coordinates and a normalized size of a region of interest on the target image; respectively calculating a full width at half maximum coefficient in the horizontal direction and the vertical direction according to the normalized size; calculating a weight value of each block using a two-dimensional discrete Gaussian function according to the normalized central coordinates and the full width at half maximum coefficient; calculating a normalized overall definition of the target image according to the weight value and definition of each block; and focusing according to the normalized overall definition. The method and apparatus can automatically calculate a mask of the region of interest, thereby avoiding the occupying of storage space required when storing ROI mask data.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: June 29, 2021
    Assignees: Suzhou Keda Technology Co., Ltd., Suzhou Keyuan Software Technology Co., Ltd., Suzhou Keda Special Video Co., Ltd.
    Inventors: Jiayang Song, Fengfeng Tang, Yong Zhang, Lijun Cao, Weidong Chen
  • Patent number: 11026649
    Abstract: A method and system for determining system-based tumor burden is disclosed. In one aspect, the method includes obtaining the medical image from a source, through an interface. Additionally, the method includes identifying a first region of interest in the medical image. The method also includes selecting from the first region of interest a second region of interest whose tumor burden is to be determined. Furthermore, the method includes defining a segmentation criterion for the second region of interest. The method also includes determining the tumor burden for the second region of interest.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: June 8, 2021
    Inventors: Mayank Gupta, Bruce S. Spottiswoode
  • Patent number: 11016196
    Abstract: A system and method of generating a two-dimensional image of an environment is provided. The system includes a 2D scanner that comprises a light source, an image sensor and a controller. The controller determines a distance value to at least one of the object points. An inertial measurement unit is coupled to the scanner and has a first sensor. The first sensor has a first characteristic. A mobile computing device is removably coupled to the 2D scanner, the mobile computing device having a second sensor, the second sensor having a second characteristic. Processors are provided that are responsive to compare the first characteristic and the second characteristic and select one of the first or second sensor based on the comparison. The processors are further generate an image of the environment based on a signal from the selected first or second sensor.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: May 25, 2021
    Inventors: Oliver Zweigle, Ahmad Ramadneh, Aleksej Frank, João Santos
  • Patent number: 11016277
    Abstract: A device is configured to carry out a method for examining a sample comprising: illuminating the sample in an illumination plane along an illumination strip by an illuminating light beam which propagates along the illumination strip, wherein the illuminating light beam is formed as a light sheet; projecting the illumination strip into a detection plane by detection light originating from the illumination strip being focused in the detection plane; and detecting the detection light by a detector. The detector is formed as a slit detector.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: May 25, 2021
    Inventors: Florian Fahrbach, Werner Knebel
  • Patent number: 11009344
    Abstract: A control section 200 executes photographing processing for controlling the light projecting section and the light receiving section to photograph a measurement object placed on a stage, contour extracting processing for extracting a contour of the measurement object from an image of the measurement object, storing processing for determining whether the measurement object is present in rectangular regions adjacent to a photographing visual field and causing a storing section to store coordinate positions of one or more of the rectangular regions where it is determined that the measurement object is present, driving processing for driving the stage-plane-direction driving section to move the photographing visual field to any one of the coordinate positions stored in the storing section by the storing processing, and coupled-image generation processing for generating a coupled image by coupling images of the rectangular regions adjacent to one another obtained by repeatedly executing the photographing processin
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: May 18, 2021
    Inventor: Kazuki Natori
  • Patent number: 11002535
    Abstract: A shape measuring device 100 includes a control section 200 for executing determination processing for determining an unmeasured region having height information is present outside a depth measurement range, which is a height range in which pattern light can be irradiated from a light projecting section, focal-position changing processing for controlling an optical-axis-direction driving section to change a focal position of a light receiving section when it is determined by the determination processing that the unmeasured region is present, and synthesis processing for generating synthesized stereoscopic shape data obtained by combining a plurality of stereoscopic shape data generated by automatically repeating the stereoscopic-shape-data acquisition processing, the determination processing, and the focal-position-changing processing until it is determined by the determination processing that the unmeasured region is absent or a predetermined end condition is satisfied.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: May 11, 2021
    Inventors: Kazuki Natori, Masaki Fujiwara
  • Patent number: 10990788
    Abstract: A camera captures an image of a subject, and a light source illuminates with light a plane intersecting an optical axis of the camera at a prescribed angle. The processor generates guidance information related to a distance between the subject and the light source on the basis of a pixel value distribution of the image of the subject which is illuminated with the light, and outputs the generated guidance information.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: April 27, 2021
    Inventors: Yukihiro Abiko, Satoshi Maeda, Soichi Hama, Satoshi Semba, Hajime Nada
  • Patent number: 10983325
    Abstract: Method and system for trans-illumination imaging. In an exemplary method, a sample is irradiated in a well. The sample may include biological cells and a liquid or semi-solid medium that forms a meniscus. The step of irradiating may be performed with an array of light sources generating light of respective light beams that are incident on the meniscus at different orientations from one another. One or more images may be detected. A proportional contribution of light from two or more subsets of the light sources to the one or more images may be controlled by differential energization of the two or more subsets relative to one another to compensate for refraction by the meniscus and improve contrast.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: April 20, 2021
    Inventor: Matthew Chan
  • Patent number: 10964063
    Abstract: The present disclosure is directed to a computer system designed to (i) receive a series of images as input; (ii) compute a number of metrics derived from focus features and color separation features within the images; and (iii) evaluate the metrics to return (a) an identification of the most suitable z-layer in a z-stack, given a series of z-layer images in a z-stack; and/or (b) an identification of those image tiles that are more suitable for cellular based scoring by a medical professional, given a series of image tiles from an area of interest of a whole slide scan.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 30, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Jeffrey Atchison, Jim Martin, Anindya Sarkar
  • Patent number: 10955293
    Abstract: According to one embodiment of the present invention, a terahertz wave concentrating module can comprise: a first lens for changing a terahertz wave, which is emitted while a terahertz Bessel beam penetrates an object to be inspected, so as to have a small angle; and a second lens for concentrating, on a detector, the terahertz wave having passed through the first lens.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: March 23, 2021
    Inventors: Gyeong-Sik Ok, Sung-Wook Choi, Hyun-Joo Chang
  • Patent number: 10951869
    Abstract: An enhanced fluorescence imaging system includes a light source for emitting non-visible and visible light and an image sensor for capturing non-visible and visible light image data. Data processing hardware performs operations that include determining a non-visible value associated with an amount of non-visible light captured by the image sensor and applying a color map to each non-visible value to generate non-visible light selected color values. The operations also include weighting a visible light chroma value with a non-visible chroma value to generate weighted chroma values and combining luma values of each pixel of the visible light image data to the weighted chroma values. The operations also include generating RGB values based on the luma values of the visible light image data and the weighted chroma values and transmitting the RGB values to the display.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 16, 2021
    Assignee: KARL STORZ Imaging, Inc.
    Inventor: Efrain Morales
  • Patent number: 10928324
    Abstract: A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 23, 2021
    Inventors: Chien-Sheng Liao, Pu Wang, Ji-Xin Cheng
  • Patent number: 10928308
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: February 23, 2021
    Assignee: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Patent number: 10921186
    Abstract: An attachment device comprising a cover, with first and second windows, is affixed to a backing, with third and fourth windows, thereby forming a casing. The first and third windows form a first optical path with light entering the third window passing through the first window. The second and fourth windows form a second optical path with light entering the second window passing through the fourth window. A filter housing with a plurality of filters is driven by a motor so that the filters intercept the first optical path in accordance with an imaging regimen electronically stored in the casing interior. The imaging regimen communicates instructions, via a communications interface of the attachment device, to an imager and light source of an external device, to which the attachment device is attached, thereby controlling these components in accordance with the regimen.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: February 16, 2021
    Inventor: Mark Anthony Darty
  • Patent number: 10923530
    Abstract: An optoelectronic device including a substrate with first and second opposite surfaces; and electrical insulation side elements extending from the first surface to the second surface and defining, within the substrate, first semi-conductive or conductive portions which are electrically insulated from each other. The optoelectronic device also includes, for each first portion a first conductive contact pad on the second surface in contact with the first portion and a set of light-emitting diodes resting on the first surface and electrically connected to the first portion. The optoelectronic device also includes a conductive, at least partially transparent electrode layer covering all the light-emitting diodes; an insulating, at least partially transparent encapsulation layer covering the electrode layer; and at least one second conductive contact pad electrically connected to the electrode layer.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: February 16, 2021
    Assignee: Aledia
    Inventors: Xavier Hugon, Ivan-Christophe Robin
  • Patent number: 10902334
    Abstract: A computer system automatically converts a set of training images of cells (e.g., oocytes or pronuclear embryos) and related outcome metadata into a description document by extracting features (e.g., cytoplasm features) from the pixel values of the training images that describe the cells and associating the extracted features with the outcome metadata. Based on the description document, the system automatically computes a decision model that can be used to predict outcomes of new cells. To predict outcomes of new cells, a computer system automatically extracts features from images that describe the new cells and predicts one or more outcomes by applying the decision model. The features extracted from the images that describe the new cells correspond to features selected for inclusion in the decision model, and are calculated in the same way as the corresponding features extracted from the training images.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: January 26, 2021
    Inventors: Gerard Letterie, Andrew MacDonald
  • Patent number: 10897580
    Abstract: An observation device 1 includes an imaging optical system 8 that forms an image on the basis of light from sample S, an aperture diaphragm 2 that changes a numerical aperture on an emission side of the imaging optical system 8, a camera 5 that converts the image of the sample into image signals, the image of the sample being formed by the imaging optical system 8, an observation scope changing unit that performs an observation scope changing process in which an observation scope is changed to a specified scope by changing an extraction scope, the extraction scope being a scope from which the image signals obtained by the camera 5 are extracted, a monitor 33 that displays the image signals from the specified scope obtained through the observation scope changing process, and a control unit that controls the aperture diaphragm 2 in accordance with the specified observation scope.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: January 19, 2021
    Inventor: Atsushi Yonetani
  • Patent number: 10895843
    Abstract: Systems, devices, and methods are described herein for performing digital holography to analyze dynamics of fluid flow. According to some aspects of this disclosure, a Digital Fresnel Reflection Holography (DFRH) system, which is arranged to utilize light backscattered from particles in a fluid chamber to create a hologram that may be processed to analyze characteristics of fluid flow. The DFRH system may utilize light reflected from an imaging window disposed between a light source and a sampling volume, to be analyzed as a reference wave, to form an interference pattern and resultant hologram. According to some aspects of this disclosure, the DFRH techniques may provide simple, cost-effective mechanisms with improved performance over other techniques for analyzing fluid flow using holography.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: January 19, 2021
    Inventors: Jiarong Hong, Santosh Kumar Sankar
  • Patent number: 10890576
    Abstract: There is provided an image processing device including an input receiver of inputting an image obtained by photographing a specimen subjected to staining and a hardware processor. The hardware processor extracts a region subjected to the staining from the image as a cell region; extracts a region as a candidate region, the region being surrounded by the cell region and not being subjected to the staining. The hardware processor further extracts a feature amount of the candidate region; determines whether or not the candidate region is a cell region on a basis of the feature amount; and corrects the candidate region which is determined to be a cell region by the distinction means to be a cell region.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: January 12, 2021
    Assignee: Konica Minolta, Inc.
    Inventor: Yusuke Mimura
  • Patent number: 10890751
    Abstract: The systems and applications for generating the augmented reality (AR) images are disclosed. The system includes a processing module and a digital microscope module having a plurality of camera units, and the processing module tracks and parses the user's motions to generate the related control signals, the virtual objects composed to form the AR images according to the received instant images of the observed objects captured by the digital microscope module. Moreover, the processing module generates and outputs the AR images composing of the instant images and the user interface (UI), icons, objects, video and/or information related to the interactive applications while the display mode switch or the real-time tutorial and sharing is triggered.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: January 12, 2021
    Inventor: Yu-Hsuan Huang
  • Patent number: 10881300
    Abstract: Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: January 5, 2021
    Assignee: HI LLC
    Inventors: Changhuei Yang, Adam Marblestone, Jamu Alford
  • Patent number: 10877259
    Abstract: A microscope system includes a microscope apparatus configured to obtain a microscopic image of a culture cell by picking up an image of the culture cell, and a first control device configured to record a culture condition of the culture cell and the microscopic image in a recording unit in association with each other.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: December 29, 2020
    Inventors: Toshiyuki Hattori, Mina Kobayashi, Naohiro Ariga, Ayumu Sakurai
  • Patent number: 10872556
    Abstract: Various embodiments of the present invention relate to a display processing method and apparatus for an electronic device having a display divided into a first area and a second area.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: December 22, 2020
    Inventor: Hyun-Woo Sim
  • Patent number: 10846854
    Abstract: Embodiments of the disclosure provide systems and methods for detecting cancer metastasis in a whole-slide image. The system may include a communication interface configured to receive the whole-slide image and a learning model. The whole-slide image is acquired by an image acquisition device. The system may also include a memory configured to store a plurality of tiles derived from the whole-slide image in a queue. The system may further include at least one processor, configured to apply the learning model to at least two tiles stored in the queue in parallel to obtain detection maps each corresponding to a tile, and detect the cancer metastasis based on the detection maps.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: November 24, 2020
    Inventors: Qi Song, Bin Kong, Shanhui Sun
  • Patent number: 10846883
    Abstract: A method for calibrating an object includes determining a position and an alignment of the object in a reference coordinate system, determining the position of at least three measurement spots by at least one capture apparatus, determining a target spot having a fixed spatial relationship with the measurement spots, determining a spatial relationship between the target spot and a tracking spot located on the object by virtue of the tracking spot being positioned at a calibration spot, and determining the spatial location of the calibration spot by a sensor.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: November 24, 2020
    Assignee: Carl Zeiss Meditec AG
    Inventors: Steffen Urban, Stefan Saur, Christian Voigt
  • Patent number: 10848658
    Abstract: The invention relates to an imager system comprising a main image sensor (1) and comprising a main matrix (2) of active pixels exhibiting a first instantaneous dynamic span of luminous sensitivity, and a main reading circuit adapted for reading the pixels of the main image sensor (1) and for acquiring a main image on the basis of said reading, an auxiliary image sensor (11) comprising a second matrix (12) of active pixels exhibiting a second instantaneous dynamic span of luminous sensitivity which is more extensive than the first instantaneous dynamic span of luminous sensitivity, and an auxiliary reading circuit adapted for reading the active pixels of the auxiliary image sensor (11) and for acquiring an auxiliary image on the basis of said reading, and a data processing unit (10) configured to determine at least one value of an acquisition parameter of the main image sensor on the basis of the auxiliary image.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: November 24, 2020
    Assignee: New Imaging Technologies
    Inventor: Yang Ni
  • Patent number: 10846882
    Abstract: An embodiment of a calibration element for an analytical microscope is described that comprises a substantially non-periodic pattern of features that exhibit contrast when illuminated by a light beam.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: November 24, 2020
    Assignee: Thermo Electron Scientific Instruments LLC
    Inventors: Francis J. Deck, Carla S. Draper, Alan Ronemus, William Robert Keefe
  • Patent number: 10838184
    Abstract: An optical device includes a sample holder configured to fix an object in the beam path of the optical device, and an illumination module which has a plurality of light sources and configured to illuminate the object from a plurality of illumination directions by operating the light sources, wherein each illumination direction has an assigned luminous field. The optical device also has a filter arranged between the illumination module and the sample holder and configured to expand the assigned luminous field for each illumination direction. As a result, it is possible to reduce artefacts on account of contaminants during the angularly-selective illumination. Techniques of digital artefact reduction are also described. By way of example, the optical device can be a microscope.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 17, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Lars Stoppe, Moritz Schmidlin, Gerhard Krampert, Kai Wicker
  • Patent number: 10831015
    Abstract: Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 10, 2020
    Assignee: Life Technologies Corporation
    Inventors: Marc Berretta, Jason Mecham, Frank Metting, Jonathan Paullin, Paul Boeschoten, Erik Persmark, Eric Altendorf
  • Patent number: 10832901
    Abstract: A method of performing Electron Energy-Loss Spectroscopy (EELS) in an electron microscope, comprising: Producing a beam of electrons from a source; Using an illuminator to direct said beam so as to irradiate the specimen; Using an imaging system to receive a flux of electrons transmitted through the specimen and direct it onto a spectroscopic apparatus comprising: A dispersion device, for dispersing said flux in a dispersion direction so as to form an EELS spectrum; and A detector, comprising a detection surface that is sub-divided into a plurality of detection zones, specifically comprising: Using at least a first detection zone, a second detection zone and a third detection zone to register a plurality of EELS spectral entities; and Reading out said first and said second detection zones whilst said third detection zone is registering one of said plurality of EELS spectral entities.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: November 10, 2020
    Assignee: FEI Company
    Inventors: Bert Henning Freitag, Sorin Lazar, Stephan Kujawa, Maarten Kuijper, Gerard Nicolaas Anne van Veen, Peter Christiaan Tiemeijer, Jamie McCormack
  • Patent number: 10809515
    Abstract: Provided is an observation method including: acquiring an observed image that has been photographed by the first specimen observation apparatus with the specimen holder being mounted on the first specimen stage, the observed image having an observation target position of a specimen positioned at a center thereof, and including the plurality of markers (Step S104); acquiring pixel coordinates of each of the plurality of markers in the observed image (Step S106); acquiring stage coordinates of each of the plurality of markers on the second specimen stage having the specimen holder mounted thereon (Step S108); and converting, based on the pixel coordinates of the plurality of markers and the stage coordinates of the plurality of markers, pixel coordinates of the center of the observed image into stage coordinates to move the second specimen stage to the obtained stage coordinates (Step S112).
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 20, 2020
    Assignee: JEOL Ltd.
    Inventor: Katsuyuki Suzuki
  • Patent number: 10809514
    Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: October 20, 2020
    Inventors: Yunlu Zou, Nicholas Newberg, Gregory Crandall
  • Patent number: 10779735
    Abstract: An image-processing method for marking plaque fluorescent reaction areas is provided, including: obtaining a first RGB image of a mouth region; obtaining a second RGB image of the mouth region; respectively converting the first RGB image and the second RGB image into a first HSV image and a second HSV image; obtaining a first average brightness value of the first HSV image and a second average brightness value of the second HSV image; normalizing the first average brightness value or the second average brightness value according the first average brightness value and the second average brightness value to obtain a normalized image; converting the normalized image into a third RGB image, and obtaining a plurality of pixel points of the dental plaque according to the third RGB image and the first RGB image or the second RGB image; and marking the pixel points in the third RGB image.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 22, 2020
    Inventors: Kai-Ju Cheng, Chin-Yuan Ting, Hsin-Lun Hsieh, Tsung-Hsin Lu, Yu-Hsun Chen, Hao-Ping Lee
  • Patent number: 10776955
    Abstract: A method for analyzing spatial and temporal information of samples using optical microscopy includes choosing a field of view in a sample; scanning the sample by applying an electrical signal having a first frequency to an electrically tunable liquid lens in the detection path, performing a sequential acquisition, at a first acquisition frequency higher than the first frequency of the electrical signal, of a stack of images placed on different in-focus planes; processing the stack of images to identify the position of one or more regions of interest; scanning the sample by applying the electrical signal having a second frequency to the tunable lens, performing a sequential acquisition, at a second acquisition frequency lower than the second frequency of the electrical signal, of a temporal series of images with extended depth of field; and calculating the mean intensity of each region of interest for each image of the temporal series.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 15, 2020
    Inventors: Francesco Difato, Monica Moroni, Gemma Palazzolo, Alessandro Soloperto
  • Patent number: 10775600
    Abstract: An inverse microscope as a smart media device platform is provided. The smart media device platform includes a lower surface, sample stage, and a light source mount. The apparatus includes a lower, middle, and upper portion. The lower portion is a base that supports the smart media device, the middle portion is for the sample stage and the upper portion is the light source mount. The lower base is coupled to the middle sample stage by multiple support pillars. The inverse microscope further includes the magnifying loop as the objective, disposed proximal to the middle portion. And a light source disposed proximal to middle portion. The magnifying loop arm may be removed and replaced with a magnifying loop arm to achieve varied loop magnification power.
    Type: Grant
    Filed: December 30, 2018
    Date of Patent: September 15, 2020
    Inventor: Stephan Roy Mathis, II
  • Patent number: 10768403
    Abstract: Techniques for acquiring focused images of a microscope slide are disclosed. During a calibration phase, a “base” focal plane is determined using non-synthetic and/or synthetic auto-focus techniques. Furthermore, offset planes are determined for color channels (or filter bands) and used to generate an auto-focus model. During subsequent scans, the auto-focus model can be used to quickly estimate the focal plane of interest for each color channel (or filter band) rather than re-employing the non-synthetic and/or synthetic auto-focus techniques.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: September 8, 2020
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Joerg Bredno, Jim F. Martin, Anindya Sarkar
  • Patent number: 10769773
    Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The method may include placing the sample on the sample-holder of a phase-contrast microscope, establishing a connection between the processor of the mobile terminal and a controller of the microscope, disposing a mobile terminal on a support so that its digital image sensor is positioned in front of an ocular, launching a counting program so that the processor performs successive counting sequences on distinct analysis areas of the sample, wherein between two counting sequences the processor controls a two-axis motorized system to displace the sample, and wherein for each counting sequence the processor implements the following steps of: setting the focus, capturing a main image, and analyzing the main image in order to count the number of fibers.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: September 8, 2020
    Assignee: XRAPID FRANCE
    Inventors: David Mendels, Xavier Mulatou
  • Patent number: 10762327
    Abstract: Provided is an image-processing device that includes: a processor including hardware; the processor configured to: analyze an image of the inside of a culture vessel that cultures cells, and acquire quantitative data of living cells and quantitative data of dead cells inside the culture vessel; and generate comparison data that allows comparison of the acquired quantitative data of the living cells and the acquired quantitative data of the dead cells.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 1, 2020
    Inventors: Takayuki Nakatomi, Satoshi Ishii, Isao Sakane, Masakazu Fujii, Akira Matsushita, Takashi Miyoshi