Abstract: A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

Abstract: A contact lens having a cap, core, and base forming three layers to allow for the contact lens to be thick enough to accommodate a payload, while ensuring sufficient oxygenation of the wearer's eye. The cap and base are each a thin layer of gas-permeable material, each shaped to form an air gap between them and the core. The two air gaps are connected by air passages that traverse the core. Oxygen from an outside environment passes through the gas-permeable cap to reach the outer air gap, through the air passages to the inner air gap, and through the gas-permeable base to reach the cornea of the wearer's eye. The cap may be annular in form, having a center hole such that the cap does not extend over the central zone of the core, reducing a thickness of the contact lens.

Abstract: A contact lens has a core thick enough to accommodate a payload. The lens further has outer and inner coverings that cover parts of the core. Each covering is a thin layer of gas-permeable material shaped to form a respective cavity between the covering and the core. Oxygen passes through the outer covering to the outer cavity, through an air path within the core to the inner cavity, and through the inner covering to reach the cornea of the wearer's eye. To increase oxygen flow, a patterned structure is formed at an interface between the core and at least one of the outer and inner covering, comprising supports at which the core and covering contact, and recesses forming the cavity between the core and covering for oxygen flow. The outer and inner coverings may be made from different types of gas-permeable materials having different levels of gas-permeability and brittleness.

Abstract: Dynamic contact lenses fabricated with a dynamic portion that extends outward from the peripheral portion are disclosed. When worn on an eye the dynamic portion forms a tear lens for correcting vision. The dynamic portion can also be configured to provide a dynamic tear lens that changes optical power with forces applied by eyelids. The dynamic portion can be configured to assume a conforming configuration and at least one non-conforming configuration, or can be configured to assume at least two non-conforming configurations. The dynamic contact lenses can be used for correcting vision such as correcting presbyopia.

Abstract: The present disclosure relates to spectacles. The spectacles include a lens including a first portion and a second portion disposed opposite each other and a first cavity between the first portion and the second portion, a frame surrounding the lens and supporting the lens, a colored liquid disposed in the interior space, a first hydrophobic dielectric film disposed on an inner surface of the frame, a first electrode disposed between the inner surface of the frame and the first hydrophobic dielectric film, and a second electrode disposed in the interior space and in contact with the colored liquid. The frame has a second cavity defined by an inner surface of the frame. The second cavity is in communication with the first cavity to form an interior space.

Abstract: An ophthalmic device includes a rigid insert and an enclosure enveloping the rigid insert. The enclosure includes a cornea contact formed on a concave side of the enclosure. The cornea contact has a ring-shape that protrudes from the concave side of the enclosure and is disposed under at least a portion of the rigid insert. The ring-shape of the cornea contact includes a plurality of discontinuous sections. The plurality of channels are disposed on the concave side of the enclosure and each extend through a corresponding one of the discontinuous sections of the cornea contact.

Abstract: The present technology is directed to an adjustable power intraocular lens comprising a container, an optical fluid in the container, and a transport substance in solution with the optical fluid. The container has an optical component and a peripheral component extending around at least a portion of the optical component. The optical component has an anterior optical element, a posterior optical element, and a fluid chamber having a chamber volume between the anterior optical element and the posterior optical element. The transport substance is configured to pass through the container. The adjustable power intraocular lens further comprises volume control elements in the container. The volume control elements are configured to be activated by a non-invasive energy and upon activation release the transport substance into the optical fluid to decrease the chamber volume and/or absorb the transport substance from the optical fluid to increase the chamber volume.

Abstract: A contact lens has a core that is thick enough to accommodate a payload. The core has a base surface for mounting the contact lens to the sclera of the user's eye. It also provides mechanical integrity to carry the payload. The contact lens also includes an outer covering and an inner covering. Each covering is a thin layer of gas-permeable material shaped to form an air gap between the covering and the core. The two air gaps are connected by an air path that traverses the core. Oxygen from an outside environment passes through the gas-permeable outer covering to reach the outer air gap, through the air path to the inner air gap, and through the gas-permeable inner covering to reach the cornea of the wearer's eye.

Abstract: A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

Abstract: A contact lens comprises a variable focal length lens embedded within the contact lens and a plurality of oxygen channels extending from an oxygen-permeable outer layer of the contact lens to an oxygen-permeable inner layer of the contact lens. The variable focal length lens is embedded within a non-oxygen-permeable core layer of the contact lens. The contact lens comprises a controller configured to change the operating mode of the contact lens by adjusting the focal distance of the variable focal length lens, for instance in response to an input from a user or in response to determining that the user is looking at a nearby object. For instance, the controller can configure the contact lens to operate in a reading mode or in a normal focus mode.

Abstract: The present invention encompasses ophthalmic compositions that may be used for various conditions of the eye, and particularly, conditions of the cornea. Also encompassed are methods that utilise these compositions and kits that include these compositions.

Abstract: A mold for a front curve of an ophthalmic lens includes an inner region having a non-rotationally symmetric shape, an outer region having a rotationally symmetric shape, and a continuous middle region between the inner region and the outer region. A first portion of the middle region is in contact with the inner region, defining a non-rotationally symmetric rim or edge of a front surface of the ophthalmic lens. A second portion of the middle region is in contact with the outer region and is rotationally symmetrical.

Abstract: Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.

Abstract: An intraocular lens (IOL) for implantation within a capsular bag of a patient's eye comprises an optical structure and a haptic structure. The optical structure comprises a planar member, a plano convex member, and a fluid optical element defined between the planar member and the plano convex member. The fluid optical element has an optical power. The haptic structure couples the planar member and the plano convex member together at a peripheral portion of the optical structure. The haptic structure comprises a fluid reservoir in fluid communication with the fluid optical element and a peripheral structure for interfacing to the lens capsule. Shape changes of the lens capsule cause one or more of volume or shape changes to the fluid optical element in correspondence to deformations in the planar member to modify the optical power of the fluid optical element.

Abstract: An accommodating contact lens comprises a control device, which comprises one or more eyelid engagement structures. The eyelid engagement structures are configured to move with the eyelid relative to the contact lens. The eyelid engagement structure is coupled to the eyelid and to the accommodating contact lens, which may comprise a fluidic module having inner and outer fluid reservoirs. The eyelid engagement structure is configured to respond to the narrowing or widening of the eyelid fissure, moving a fluid in or out of the inner reservoir to accommodate near or far vision.

Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.

Abstract: A liquid lens includes a sealed shell, a liquid material, a transparent carbon nanotube structure within the liquid material, and a first electrode and a second electrode, a voltage being applied to the carbon nanotube structure causes rapid heating, which is transferred to the liquid material to change the density thereof, and the refractive index of the liquid material is thus changed.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with one or more folds of the bellows extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes when the eye accommodates.

Abstract: A spectacle lens is produced through a first step of stacking a first member colored in cyan and a second member colored in red and integrating the first member and the second member, and a subsequent second step of partially polishing a periphery of a convex surface of the first member. Provision of the polishing step enables unique design and production of appropriate numbers of widely varied distinctive spectacle lenses.

Abstract: Methods of forming a lens include forming components on a lower substrate. The components are sealed on the lower substrate with a sealing layer. An upper substrate is formed over the sealing layer. The lower substrate is polished to a lower lens curvature.

Abstract: A silicone elastomer-hydrogel hybrid contact lens includes a silicone elastomer layer and a hydrogel layer adhered to the silicone elastomer layer by a delamination-resistant bond that is formed by an elastomer-swellable monomer that is included in the polymerizable composition used to form the hydrogel layer.

Abstract: Methods and apparatus to enhance levels of oxygen in tear fluid under a worn advanced contact lens are described. The contact lens may include an encapsulated hard lens element which is impermeable to fluid flow across its body. The method of enhancement may include creating pores through the hard lens element, creating channels in portions of the contact lens body, including layers of absorptive material, and creating means of moving tear fluid under the contact lens.

Abstract: Methods and apparatus to enhance levels of oxygen in tear fluid under a worn advanced contact lens are described. The advanced contact lens may include an insert which is impermeable to fluid flow across its body. The method of enhancement may include creating pores through the insert, creating channels in portions of the contact lens body, including layers of absorptive material, including devices to generate or release oxygen or means of moving tear fluid under the contact lens.

Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.

Abstract: An actuation mechanism for simultaneous actuation of first and second variable focal length lenses is disclosed. Each lens comprises a distensible membrane bounding a fluid-filled cavity, the focal length varying with the degree of curvature of the membrane as it distends. The actuation mechanism comprises a hydraulic master actuator in fluid communication with a hydraulic slave actuator associated with the first lens and with a hydraulic slave actuator associated with the second lens. Each slave actuator is configured to vary the degree of distension of the membrane of its associated lens in response to operation of the master actuator, whereby the master actuator is operable to cause a variation of the degree of distension of the membranes of both the first and second lenses simultaneously.

Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention.

Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention.

Abstract: A hybrid contact lens has a rigid gas permeable (RGP) central portion and a soft flexible portion that extends outward from the RGP central portion. The soft flexible portion defines the posterior surface and base curve of the hybrid contact lens that contacts a user's cornea, such that the RGP central portion does not contact the user's cornea while wearing the hybrid contact lens. The hybrid contact lens can be a single lens system with one optical power, or a dual lens system with two different optical powers.

Abstract: A lens for correcting vision of a user includes a central zone and an outer zone. The central zone is configured to cause light passing therethrough to form an image on a retina of an eye of the user. The outer zone surrounds the central zone and has a plurality of different aspherical coefficients for respectively causing light passing therethrough to form images spaced apart from the retina.

Abstract: An artificial lens for an eye (10) is described. According to the present invention, an artificial lens for an eye is now provided, in which the focal width can change. This is realized according to the invention by providing the artificial lens with two or more media (12, 13) that are flexible in shape as lens elements and that the two media that are flexible in shape stand in direct contact with one another. The media that are flexible in shape are preferably disposed in an uptake container forming a lens body (11).

Abstract: A lens blank for a fluid lens includes a rigid lens and a semi-flexible inflatable membrane attached to the rigid lens. The lens blank is divided into a cavity zone and a bonded zone. The cavity zone extends radially outward from a central area of the lens blank and a cavity is formed between the membrane and the rigid lens within the cavity zone. The bonded zone extends radially outward from the cavity zone and the membrane is bonded and fluidly sealed to the rigid lens throughout the bonded zone. The bonded zone is dimensioned to be trimmed to accommodate a plurality of frame shapes and sizes. Methods of manufacturing lens blanks are also provided. Arrays of lens blanks and fluid lenses are also provided.

Abstract: The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.

Abstract: The present invention describes methods for creating single-piece or multi-piece Rigid Inserts that may be included in an Ophthalmic Lenses or may comprise the Ophthalmic Lens, wherein the Rigid Insert may be formed through the processing of thin sheet material by thermoforming. Single piece annular Rigid Inserts may perform the function of providing a template for printed patterns to be included in Ophthalmic Lenses. Single piece full Rigid Inserts may perform the function of polarizing light or filtering light based on the properties of materials used to form the insert. Multi-piece Rigid Inserts may incorporate activation and energization elements. The present invention also includes apparatus for implementing such methods, as well as Ophthalmic Lenses and inserts formed with the Rigid Insert pieces that have been thermoformed.

Abstract: A variable focus ophthalmic device is described. The device comprises a front curve optical portion of the variable focus ophthalmic device comprising a front curve top optical surface and a front curve bottom optical surface and a back curve optical portion of the variable focus ophthalmic device comprising a back curve top optical surface and a back curve bottom optical surface. A cavity is formed by the front curve bottom optical surface of the front curve optical portion of the variable focus ophthalmic device and the back curve top optical surface of the back curve portion of the variable focus ophthalmic device. A first fluid with a first index of refraction and a second fluid with a second index of refraction is provided, wherein the first index of refraction and the second index of refraction are different and the two fluids are immiscible.

Abstract: A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed at an interior junction of the disc and the peripheral curved portion, and one or more apertures formed in the groove.

Abstract: Contact lenses may be designed with locally thinned regions to increase oxygen transmissibility to the eye. The locally thinned regions are preferably positioned outside of the optic zone and in the thicker peripheral zone. For a contact lens formed from a specific material, creating local thinner regions, for example, dimples in the back curve surface of the lens, provides an effective and efficient means for increasing oxygen diffusion.

Abstract: A contact lens assembly includes a proximal layer formed from a gas-permeable material, a distal layer with an optical element, an air cavity disposed between the proximal layer and the distal layer, wherein oxygen concentration across the air cavity is substantially uniform, and an gas transport region surrounding the air cavity for communicating gas between the air cavity and atmosphere. The contact lens assembly may further include a plurality of fins disposed within the air cavity where the plurality of fins has openings therethrough. One or both of the upper and lower surfaces of the air cavity may have an anti-reflection coating formed thereon.

Abstract: Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion having a scaffold between an anterior portion and a posterior portion. The scaffold is characterized by a substantially uniform thickness formed from a material characterized by a modulus that his higher than the modulus of the peripheral portion. Openings within the scaffold are filled with a low modulus material. When applied to an eye, the lenses are configured to provide one or more lenticular volumes between the posterior surface of the lens and the cornea. The disclosure further relates to methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses.

Abstract: A large diameter, rigid, gas permeable, corneal-scleral progressive, multifocal vision contacty lens that covers the cornea and a portion of the sclera of an eye. It is particularly beneficial for use on patients who have undergone refractive surgery and/or on patients experiencing presbyopia. The lens is designed to have dual touch contact with an eye. One contact point is the central portion of the cornea and the other contact point is a portion of the sclera.

Abstract: Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed.

Abstract: This invention relates to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections wherein said pH indicator is entrapped in the lens. Other aspects relate to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections and a biodegradable coating with a biocompatible colorant entrapped within the coating useful for determining the usable lifespan of the contact lens. Other aspects relate to methods of using such contact lenses.

Abstract: This invention discloses methods and apparatus to form thin film nanocrystal integrated circuit transistors upon three dimensionally formed insert devices. In some embodiments, the present invention includes incorporating the three dimensional surfaces with thin film nanocrystal integrated circuit based thin film transistors, electrical interconnects and energization elements into an insert for incorporation into ophthalmic lenses. In some embodiments the formed insert may be directly used as an ophthalmic device or incorporated into an ophthalmic device.

Abstract: Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion configured to be disposed over the optical region of the cornea and having a central portion disposed between an anterior portion and a posterior portion. The inner optic portion is configured to at least partially diverge from the shape of the cornea to provide at least one lenticular volume between a posterior surface of the inner optic portion and the cornea. The central portion may be characterized by a thickness from 50 ?m to 900 ?m and a modulus form 20 MPa to 1500 MPa.

Abstract: The present disclosure relates generally to multicomponent optical devices having a space within the device. In various embodiments, an optical device comprises a first posterior component having an anterior surface, a posterior support component, and an anterior component having a posterior surface. An optical device can also comprise an anterior skirt. The first posterior component and the anterior skirt can comprise gas-permeable optical materials. An optical device also comprises a primary space between the posterior surface and the anterior surface, with the primary space configured to permit diffusion of a gas from a perimeter of the primary space through the space and across the anterior surface of the first posterior component. A method of forming a multicomponent optical device having a space is also provided.

Abstract: The present disclosure relates generally to multicomponent optical devices having a space within the device. In various embodiments, an optical device comprises a first posterior component having an anterior surface, a posterior support component, and an anterior component having a posterior surface. An optical device can also comprise an anterior skirt. The first posterior component and the anterior skirt can comprise gas-permeable optical materials. An optical device also comprises a primary space between the posterior surface and the anterior surface, with the primary space configured to permit diffusion of a gas from a perimeter of the primary space through the space and across the anterior surface of the first posterior component. A method of forming a multicomponent optical device having a space is also provided.

Abstract: An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

Abstract: An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

Abstract: An ophthalmic device having improved oxygen transmissibility is provided. The ophthalmic device includes a hydrogel lens wherein the peripheral zone of the hydrogel lens includes a plurality of raised portions on the surface of the lens proximal to the ocular surface.

Abstract: A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed at an interior junction of the disc and the peripheral curved portion, and one or more apertures formed in the groove.

Abstract: The present disclosure relates generally to multicomponent optical devices having a space within the device. In various embodiments, an optical device comprises a first posterior component having an anterior surface, a posterior support component, and an anterior component having a posterior surface. An optical device can also comprise an anterior skirt. The first posterior component and the anterior skirt can comprise gas-permeable optical materials. An optical device also comprises a primary space between the posterior surface and the anterior surface, with the primary space configured to permit diffusion of a gas from a perimeter of the primary space through the space and across the anterior surface of the first posterior component. A method of forming a multicomponent optical device having a space is also provided.