Abstract: Provided are a fluorescence generating device and a digital PCR analysis system including the same. The fluorescence generating device includes a clad layer on a substrate, an optical waveguide arranged in a first direction within the clad layer, and a housing which is disposed on the optical waveguide and the clad layer and has a micro fluid channel extending in a second direction. The optical waveguide includes an input waveguide which is provided within one side of the clad layer and provides excitation light to a liquid drop within the micro fluid channel to generate fluorescent light, and an output waveguide which is provided within the other side of the clad layer and has an output inclined surface that reflects the fluorescent light.

Abstract: A system and method for colorimetric calibration is described herein. A system for performing color calibration is described, comprising at least one broad spectrum light emitting diode, at least one light diffuser plate, at least one interference filter, and a camera, the camera comprising at least one sensor for detection of colors, wherein a spectral response within 5% error of a ground truth method can be achieved. A method for performing color calibration is described, comprising transmitting light from at least one broad spectrum light emitting diode, scattering light with at least one light diffuser plate, filtering light with at least one interference filter, detecting light at a camera sensor, mapping an intensity value for each pixel of the camera sensor, and creating a quantum efficiency curve for each of red, green, and blue channels.

Abstract: A device for light-based analysis of a substance in a liquid sample comprises: an analysis cell for holding the liquid sample; wherein the analysis cell comprises a first wall portion for passing light generated by a light source into the analysis cell, and a second wall portion for passing light from the analysis cell to a light detector; and a plunger configured for movement along walls of the analysis cell for allowing entry of the liquid sample into the analysis cell and pushing the liquid sample out of the analysis cell; wherein at least one wiper is arranged on the plunger for cleaning the first and second wall portions during movement of the plunger.

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.

Abstract: Systems and methods are disclosed that utilize metal nanostructures that are synthesized in situ along the internal surfaces of a microfluidic device. The nanostructures are formed by initial deposition of metallic seeds followed by flowing growth and reducing agent solutions into the capillaries/microfluidic channels to grow the nanostars. The nanostructures may optionally be functionalized with a capture ligand. The capture ligand may be used to selectively bind to certain cells (e.g., circulating tumor cells). The cells may be removed by a beam of light (e.g., laser beam) that induces localized heating at the surface location(s) containing the nanostructures. The plasmonic nature of the nanostructures can be used to heat the nanostructure(s) locally for the selective removal of one or certain cells. The nanostructures may be used to acquire Raman spectra of molecules or other small objects that are bound thereto for identification and quantification.

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.

Abstract: Systems and methods are provided which utilize optical microcavity probes to map wafer topography by near-field interactions therebetween in a manner which complies with high volume metrology requirements. The optical microcavity probes detect features on a wafer by shifts in an interference signal between reference radiation and near-field interactions of radiation in the microcavities and wafer features, such as device features and metrology target features. Various illumination and detection configurations provide quick and sensitive signals which are used to enhance optical metrology measurements with respect to their accuracy and sensitivity. The optical microcavity probes may be scanned at a controlled height and position with respect to the wafer and provide information concerning the spatial relations between device and target features.

Abstract: A method for diagnosing a lubricant containing an additive, is executed by an information processor. Chromaticity information of the lubricant which is a diagnosis target is obtained from an input device, the chromaticity information is obtained by an optical sensor, and a storage device stores a deterioration curve of the lubricant which is the diagnosis target, the deterioration curve is determined in advance regarding a transition in a chromaticity coordinate caused by a deterioration, and a chromaticity coordinate corresponding to a limit contamination level determined in advance using a contaminated lubricant. The processing device obtains a chromaticity coordinate of the lubricant from the chromaticity information and uses a relative contamination level obtained from a distance of the chromaticity coordinate of the lubricant from the deterioration curve and a distance of the chromaticity coordinate corresponding to the limit contamination level from the deterioration curve.

Abstract: An apparatus for measuring the absorbance of a substance in a solution, includes at least one sample cell arranged to contain the solution that is at least partially transparent to light of a predefined wavelength spectrum, at least two light passages through the at least one sample cell, each of the light passages having a known path length, an LED light source arrangement including at least two LEDs, each arranged to emit a light output with a wavelength within the predefined wavelength spectrum. A plurality of optical fibers, one for each light passage, is arranged at each LED for receiving the light output and guiding it to the light passages. A method for measuring the absorbance of a substance in a solution includes providing the LED light source arrangement with an associate fiber bundle for each LED.

Abstract: Systems and methods for performing a contamination estimation of a downhole sample including at least a formation fluid and a filtrate are provided. A plurality of downhole signals are obtained from the downhole sample and one or more of the signals are conditioned. At least two of the conditioned signals or downhole signals are fused into a multivariate dataset. A principle component analysis (PCA) is performed on the fused multivariate dataset to determine optical and density properties of the formation fluid. Based on at least the PCA, optical and density properties of the filtrate are determined. From the optical and density properties of the formation fluid and of the filtrate, a multivariate calculation is performed to generate concentration profiles of the formation fluid and the filtrate.

Abstract: Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Abstract: Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.

Abstract: Provided is an effluent treatment method based on a membrane separation activated sludge method, the effluent treatment method being characterized in that activated sludge collected from a membrane separation activated sludge tank is observed by an optical means, image processing is performed, and effluent treatment conditions are controlled in accordance with the results thereof.

Abstract: A novel cell for generating ozonated water including an integrated ozone concentration detector. The cell comprises a nafion membrane separating a diamond coated anode, and a gold surfaced cathode enclosed within a cell housing with the catalyst side of the nafion membrane facing the cathode. The cell housing has a cathode housing portion and an anode housing portion separated by the membrane. The cathode and anode have an array of holes allowing fluid to penetrate to the surface of the niobium membrane. Ozonated water from the anode is channeled to a spectrophotometer integrated within the housing. The spectrophotometer creates a signal representative of the ozone concentration in the ozonated water which is utilized by control circuitry in a closed loop to maintain a stable target concentration. A bubble trap may be integrated within the housing through which the ozonated water passes before entering the spectrophotometer to remove bubbles form the ozonated water.

Abstract: Methods and instruments for measuring a liquid sample (S1) in a well plate (50) by means of an optical chip 10. The chip (10) comprises an optical sensor (13) that is accessible to the liquid sample (S1) at a sampling area (SA) of the chip. A free-space optical coupler (11,12) is accessible to receive input light (L1) and/or emit output light (L2) via a coupling area (CA) of the chip (10). The sampling area (SA) of the chip 10 is submerged in the liquid sample (S1) while keeping the liquid sample (S1) away from the coupling area (CA) for interrogating the optical coupler (11,12) via an optical path (P) that does not pass through the liquid sample (S1).

Abstract: A virtual image generation system for use by an end user comprises a projection subsystem configured for generating a collimated light beam, and a display configured emitting light rays in response to the collimated light beam to display a pixel of an image frame to the end user. The pixel has a location encoded with angles of the emitted light rays. The virtual image generation system further comprises a sensing assembly configured for sensing at least one parameter indicative of at least one of the emitted light ray angles, and a control subsystem configured for generating image data defining a location of the pixel, and controlling an angle of the light beam relative to the display based on the defined location of the pixel and the sensed parameter(s).

Abstract: A coating/developing device includes: a first laser unit that irradiates a coating liquid with laser light and acquires a state of the coating liquid based on a change in the laser light; and an irradiation propriety determination mechanism that determines whether the first laser unit irradiates the coating liquid with the laser light based on the coating liquid on a liquid bottle side of a position where the laser light is irradiated from the first laser unit in a flow path. The irradiation propriety determination mechanism includes: a second laser unit that acquires color information of the coating liquid; and a controller. The controller determines whether the color information of the coating liquid is predetermined color information that readily absorbs a wavelength of the light irradiated by the first laser unit and executes determining whether to irradiate the coating liquid with the laser light based on the determination result.

Abstract: Multi-pass cavities for cavity ring-down spectroscopy. The multi-pass cavity includes, in one example, a body, a pair of flat mirrors, a light input coupler, a first turning mirror, a second turning mirror, and a light output coupler. The pair of flat mirrors are positioned parallel to each other within a gas channel of the body. The light input coupler is configured to direct a light beam into the gas channel along a first transmission axis. The first turning mirror is configured to reflect the light beam from the first transmission axis toward the resonance cavity. The light output coupler is configured to direct a first portion of the light beam out of the gas channel and reflect a second portion of the light beam along a second transmission axis. The second turning mirror is configured to reflect the light beam from the second transmission axis to the resonance cavity.

Abstract: The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

Abstract: The present disclosure relates generally to a system and method for increasing the reliability and data-rate transmission of information from a downhole device to the surface and from the surface to the downhole device. A fluid sampling system may comprise a downhole tool positionable in a wellbore and comprising a fluid testing chamber. The downhole tool may also comprise a light spectrum analysis unit disposed at a surface of the wellbore, wherein the light spectrum analysis unit comprises a detector. The downhole tool may further comprise a fiber optic cable for carrying light from the downhole tool to the light spectrum analysis unit, wherein the fiber optic cable is connected to the downhole tool and the light spectrum analysis unit.

Abstract: A gas analysis system with an FTIR spectrometer preferably utilizes a long path gas cell, a narrow band detector, and an optical filter that narrows the detection region to measure hydrogen sulfide.

Abstract: A fluid to be optically monitored may be optically mixed to modify the apparent color perceived by a colorimetric optical sensor device. The fluid is positioned within a fluid compartment of a vessel also including a contrast compartment adjacent to the fluid compartment. The contrast compartment is configured to have a contrast color with a known main wavelength that is different from the main wavelength of the fluid color. Light from a broadband light source of the colorimetric optical sensor device is reflected off of the vessel, with the received light being received by an optical spectrometer. The optical spectrometer analyzes the received light to determine a main wavelength of the received light, followed by a controller determining a characteristic of the fluid, which is based on the main wavelengths of the received light and the contrast color and the percentage of the vessel occupied by the fluid compartment.

Abstract: A method and system can include positioning an optical waveguide along a wellbore, and launching one or more optical signals into the waveguide at one or more optical signal frequencies and during one or more time periods, thereby resulting in one or more backscattered signals being received by the receiver, which produces a trace for each of the one of more backscattered signals. Changing an environmental condition in the wellbore, generating additional backscattered light signals at one or more frequencies after the change. Comparing the traces generated before the condition change to those generated after the change, identifying a before trace and an after trace that are substantially equal to each other and identifying a frequency difference between these traces. The frequency difference can be used to determine the amount of change in the environmental condition that occurred when the environmental change event happened.

Abstract: An optical flow meter includes a substrate; a microchannel with a fluid receiver; a fluid transmitter; a fluid member with an optical interaction region; a photo interaction region; an analytical light path, such that analytical light interacts with an analyte in a photo interaction region subsequent to an interaction of a pre-analyte with activation light in an optical interaction region to produce analyte; and a detection light path disposed in the substrate, arranged at an oblique angle or right angle to the fluid member proximate to the photo interaction region, and that: receives the photoanalyte light from the photo interaction region; and communicates the photoanalyte light from the microchannel to a photodetector, the optical flow meter determines a flow rate of the analyte.

Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field and optionally one or more sources of excitation light.

Abstract: Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Abstract: Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Abstract: A compact mmW spectroscopy cell system for detecting volatile organic compounds (compounds) in a gas. The system includes a gas collection chamber, an input buffer cavity for receiving the gas from the gas collection chamber, pumping devices to pass the gas from the buffer cavity to an absorption cell and maintain pressure, and a transceiver connected to the cell. The transceiver interrogates the absorption cell filled with the gas by passing a high frequency electromagnetic signal and sweeping the signal to generate an absorption spectra which is compared to a spectroscopy database for detecting the compounds in the gas. The absorption cell, collection chambers, and pumping devices are fabricated with standard CMOS processing techniques at chip and wafer scale. The transceiver bonded to the absorption cell with chip scale integration.

Abstract: A virtual image generation system for use by an end user comprises a projection subsystem configured for generating a collimated light beam, and a display configured emitting light rays in response to the collimated light beam to display a pixel of an image frame to the end user. The pixel has a location encoded with angles of the emitted light rays. The virtual image generation system further comprises a sensing assembly configured for sensing at least one parameter indicative of at least one of the emitted light ray angles, and a control subsystem configured for generating image data defining a location of the pixel, and controlling an angle of the light beam relative to the display based on the defined location of the pixel and the sensed parameter(s).

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

Abstract: An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a specimen analysis disc having reaction regions on which nanoparticles binding to substances to be detected are captured. The optical pickup emits laser light to each reaction region, receives a reflected light from each reaction region, and generates a light reception level signal. The controller sequentially generates a plurality of measurement gate signals for counting the number of the nanoparticles captured on each reaction region, counts the number of the nanoparticles of each of the measurement gate signals based on the light reception level signal, specifies a measurement gate section in each reaction region according to a measurement result per measurement gate signal, and adds up the number of the nanoparticles of the respective measurement gate signals in the measurement gate section.

Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

Abstract: There are provided an apparatus capable of treating biological particles in a sterile state, and a treatment apparatus. An apparatus for forming a liquid flow including biological particles includes: a chamber member; a sample liquid supply portion; a sheath liquid supply portion; and a vibrating electrode member. The chamber member includes a chamber and a flow cell extending from an interior to an exterior of the chamber. The sample liquid supply portion is configured to supply a sample liquid including the biological particles into the chamber. The sheath liquid supply portion is configured to supply a sheath liquid into the chamber. The vibrating electrode member extends from the interior to the exterior of the chamber, is made of an electrically conductive material, and is configured to be capable of supplying an electric charge to the sheath liquid and the sample liquid in the chamber and propagating an ultrasonic vibration.

Abstract: System and method of quantifying a gas leak in a specified field of view are disclosed. The system may comprise a cooled detector and two interchangeable band-pass non-cooled filters. A first non-cooled band-pass filter transmits electromagnetic radiation in a first spectral band that coincides with a non-transparent leaking gas spectral band. A second non-cooled band-pass filter transmits only electromagnetic radiation in a second spectral band which coincides with a transparent leaking gas spectral band. The system may comprise a quantification unit arranged to process the images generated by the cooled detector to thereby determine, based on the images thereof, a flowrate of the leaking gas in the specified field of view. The system may comprise a detection unit arranged to determine, based on alternately generated multiple first spectral band images and multiple second spectral band images, a gas leak in the specified field of view.

Abstract: Embodiments of the present invention relate to a microring resonator control method and apparatus. The method includes: receiving an instruction, where the instruction is used to configure an operating wavelength of a microring resonator; determining whether the operating wavelength of the microring resonator is less than or equal to a center wavelength of a channel spectrum; and when the operating wavelength of the microring resonator is less than or equal to the center wavelength of the channel spectrum, configuring thermode power of the microring resonator based on a spacing between the operating wavelength and a first wavelength; or when the operating wavelength of the microring resonator is greater than the center wavelength of the channel spectrum, configuring thermode power of the microring resonator based on a spacing between the operating wavelength and a second wavelength.

Abstract: A virtual image generation system for use by an end user comprises a projection subsystem configured for generating a collimated light beam, and a display configured emitting light rays in response to the collimated light beam to display a pixel of an image frame to the end user. The pixel has a location encoded with angles of the emitted light rays. The virtual image generation system further comprises a sensing assembly configured for sensing at least one parameter indicative of at least one of the emitted light ray angles, and a control subsystem configured for generating image data defining a location of the pixel, and controlling an angle of the light beam relative to the display based on the defined location of the pixel and the sensed parameter(s).

Abstract: An optical immersion probe assembly with an alignment mechanism is described. The alignment mechanism ensures that proper alignment is achieved between an optical fiber head and an optical immersion probe whenever the optical immersion probe is coupled to the optical fiber head. The alignment mechanism may include a notch defined in a portion of a first annular end surface of the optical fiber head, and a projection on a periphery of the optical immersion probe. The projection on the probe may be positioned a distance from a second annular end surface of the optical immersion probe, and sized to be received within the notch of the optical fiber head. Also described herein are techniques and processes for manufacturing the components of an optical immersion probe assembly, and for assembling the optical immersion probe assembly.

Abstract: A flow cell analyzes a fluid sample. A flow cell body contains a reference material and includes at least one hollow chamber to contain the fluid sample. Opposing surfaces of the flow cell body each have at least one transparent portion thereof. An optical path for light traversing through the flow cell body is defined in part by the transparent portions. A switching mechanism adjusts the amount of the reference material in the optical path to effect switching of the flow cell between a reference measurement state and a fluid sample measurement state. The reference measurement state corresponds to a first light intensity measurement and the fluid sample measurement state corresponds to a second light intensity measurement.

Abstract: A fluid analyzer includes a substrate, a quantum cascade laser formed on a surface of the substrate and including a first light-emitting surface and a second light-emitting surface facing each other in a predetermined direction parallel to the surface, a quantum cascade detector formed on the surface and including the same layer structure as the quantum cascade laser and a light incident surface facing the second light-emitting surface in the predetermined direction, and an optical element disposed on an optical path of light emitted from the first light-emitting surface across an inspection region in which a fluid to be analyzed is to be disposed and reflecting the light to feed the light back to the first light-emitting surface.

Abstract: Devices and methods are provided for breath gas analysis when determining the difference in the concentrations of at least one gas in the exhaled breathing air on the one hand and in the ambient air on the other hand. The device may include at least one gas sensor, by means of which the concentration of a gas can be determined, and a line system, through whose lines the exhaled air to be examined, the ambient air and a calibrating gas can be selectively pumped to the gas sensor. The method may include feeding ambient air; feeding calibrating gas to the gas sensor; feeding exhaled air to the gas sensor; feeding calibrating gas to the gas sensor again; and feeding exhaled air to the gas sensor again.

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

Abstract: A virtual image generation system for use by an end user comprises a projection subsystem configured for generating a collimated light beam, and a display configured emitting light rays in response to the collimated light beam to display a pixel of an image frame to the end user. The pixel has a location encoded with angles of the emitted light rays. The virtual image generation system further comprises a sensing assembly configured for sensing at least one parameter indicative of at least one of the emitted light ray angles, and a control subsystem configured for generating image data defining a location of the pixel, and controlling an angle of the light beam relative to the display based on the defined location of the pixel and the sensed parameter(s).

Abstract: A microorganism evaluation system comprising a viewing section for image acquisition, the viewing section comprising a viewing port configured to accommodate a fluid flow, at least one independently controlled imaging light source operably installed in the viewing section and configured to selectively illuminate the viewing port, and at least one independently controlled light stimulation device operably installed in the viewing section and configured to selectively emit light for invoking a motile response in a microorganism within the fluid flow in the viewing port, whereby the system synchronizes illumination of the at least one imaging light source and the at least one light stimulation device of the viewing section.

Abstract: Devices, methods, systems, and computer-readable media for a dual wavelength source gas sensor are described herein. One or more embodiments include a gas sensor, comprising: a dual wavelength source to transmit a first wavelength and a second wavelength via an optical path, wherein a gas is present through the optical path, a detector to receive the first wavelength and the second wavelength via the optical path, and a computing device coupled to the detector to determine an determine a signal intensity for the first wavelength and the second wavelength.

Abstract: A virtual image generation system for use by an end user comprises a projection subsystem configured for generating a collimated light beam, and a display configured emitting light rays in response to the collimated light beam to display a pixel of an image frame to the end user. The pixel has a location encoded with angles of the emitted light rays. The virtual image generation system further comprises a sensing assembly configured for sensing at least one parameter indicative of at least one of the emitted light ray angles, and a control subsystem configured for generating image data defining a location of the pixel, and controlling an angle of the light beam relative to the display based on the defined location of the pixel and the sensed parameter(s).

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

Abstract: Gas detector tubes may be used to determine a concentration of target gases in air. The gas detector tubes described may be read either by and optical reader or visually by the user. A gas detector tube reader having an optical reader capable of reading a length of stain, a color change and color density of a reagent in a gas detector tube. The gas detector tube may further comprise sensors for measuring the environmental conditions during sampling.