With Significant Sample Holder Or Supply Patents (Class 356/440)
  • Patent number: 10324025
    Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: June 18, 2019
    Assignee: Instrumentation Laboratory Company
    Inventors: Brian Joseph Bosy, Josef Kerimo
  • Patent number: 10184929
    Abstract: Approximations to distinguish between X sperm and Y sperm are obtained by detecting light scattered into a pre-set angular range. The scattered light is scattered in turn by nuclei of sperm moving single-file in a sample container. The sperm are not modified prior to the light scattering and are not modified by the light scattering. Approximations are improved by at least a second detection of scattered light.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: January 22, 2019
    Inventor: Satish Deshpande
  • Patent number: 9952142
    Abstract: The invention relates to a device (1) for the light spectroscopic analysis of a small amount of a liquid sample, comprising a receiving point (3) for receiving small amounts of the liquid sample, and light conductors (5, 6) which guide light of a light source to the sample and guide signal light from the sample in the direction of a detector, and is characterised in that an illumination source (7) is arranged below the receiving point (3), and a region (8) below the receiving point (3) which is permeable for the light of the illumination source (7), is provided such that the illumination light illuminates the receiving point (3).
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: April 24, 2018
    Assignee: Implen GmbH
    Inventor: Thomas Sahiri
  • Patent number: 9939373
    Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 10, 2018
    Assignee: C Technologies Inc
    Inventors: Mark Salemo, I-Tsung Shih, Craig Harrison
  • Patent number: 9891204
    Abstract: The present invention provides a heavy metal detecting device and the fabricating method thereof. The heavy metal detecting device includes a substrate and a nano-metal-particle array. The fabricating method of the heavy metal detecting device includes following steps of: (S1) preparing a substrate, cleaning the substrate with a first liquid, and drying the substrate with a first gas; (S2) soaking the substrate in a first solution; (S3) after soaking the substrate for a first period of time, cleaning and drying the substrate with the first liquid and the first gas respectively; (S4) soaking the substrate in a pre-synthesized nano-metal-particle solution; and (S5) after soaking the substrate for a second period of time, cleaning and drying the substrate with a second liquid and the first gas respectively. Compared to the prior arts, the heavy metal detecting device of the present invention has the advantages of simplicity and rapidity.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: February 13, 2018
    Assignee: National Tsing Hua University
    Inventors: De-Hui Wan, Shih-Yu Tseng, Shang-Yi Yi
  • Patent number: 9863969
    Abstract: A method of evaporation control of a sample which is stored in a thermally insulated state is configured for preventing evaporation or denaturing of the samples and specimens. The method includes carrying the samples contained in individual containers out from a cold container having a capability of cold storage. An elapsed time that each sample container has been removed from the cold container is measured and is compared with a preset time. If the elapsed time is less than the preset time, the sample container can be returned to the cold container. An alarm is output if the elapsed time exceeds the preset time.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: January 9, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kuniaki Onizawa, Koichi Obari, Junichi Oizumi, Shigemi Oba, Tetsuaki Abe
  • Patent number: 9696261
    Abstract: A multi-channel device includes up to three channels for optical testing of liquid samples. The liquid sample(s) may include surface water, drinking water, processed water or the like. The multi-channel device may include a turbidity channel and a color channel that measure turbidity and color, respectively, of a liquid sample using spectrographic analysis. The multi-channel device may also include a colorimetric channel that measures the concentration of various analytes in a liquid sample, such as free chlorine, total chlorine, copper and phosphate.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: July 4, 2017
    Assignee: Ecolab USA Inc.
    Inventors: Eugene Tokhtuev, Christopher J. Owen, Viktor Slobodyan, William M. Christensen, Paul Schilling, Joseph Phillip Erickson
  • Patent number: 9680271
    Abstract: Systems for analyte detection are disclosed. The system includes absorption channels positioned along a surface of an object. The absorption channels are configured to trap an analyte. The system further includes a sensor embedded in the object and configured to detect the presence of the analyte. The sensor includes a light source configured to transmit light and a detector configured to detect a change in an intensity of light transmitted by the light source. The sensor further includes a cable configured to connect the light source to the detector, wherein the cable comprises detection regions, and wherein the detection regions include a portion of the cable exposed to the analyte in the absorption channel.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: June 13, 2017
    Assignee: McGill University
    Inventors: Jonathan Ikola Saari, Nate Quitoriano, James Forbes, Gordon Roberts
  • Patent number: 9593575
    Abstract: A system and method for determining characteristics of a multiphase flow in a well/pipe are disclosed. The disclosed system and method use an optical immersion probe including a flow gap across which two or more types of radiation are transmitted in order to measure absorptions of two or more substances within the multiphase flow. Primarily, broadband ultraviolet (UV) and/or near infrared radiations (NIR) are utilized with the probe to gather absorption data at and/or around at least one of the water peaks and at and/or around one or more oil or oil-condensate peaks. This data may be utilized to calculate the water-cut of the multiphase flow over a wider range of gas volume fractions. Additionally, pressure ports having pressure sensors being located on the optical immersion probe for determining the impact pressures and flow rates of different phases of the multiphase flow may also be used.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: March 14, 2017
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventor: Cheng-Gang Xie
  • Patent number: 9535003
    Abstract: There are provided an SPR sensor cell and sensor, both having very excellent detection sensitivity. The SPR sensor cell includes: an under-cladding layer; a core layer, at least a part of the core layer being adjacent to the under-cladding layer; and a metal layer covering the core layer. The core layer includes a uniform layer and a gradient layer arranged between the uniform layer and the under-cladding layer; a refractive index NCO of the uniform layer satisfies a relationship of 1.34?NCO<1.44; a refractive index NCL of the under-cladding layer and the refractive index NCO of the uniform layer satisfy a relationship of NCO?NCL?0.020; and a refractive index of the gradient layer gradually increases from an under-cladding layer side to a uniform layer side in a thickness direction of the gradient layer within a range of from more than the NCL to less than the NCO.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 3, 2017
    Assignee: NITTO DENKO CORPORATION
    Inventors: Hajime Nishio, Tomohiro Kontani
  • Patent number: 9404362
    Abstract: An apparatus for measuring fluid characteristics includes: a solid transparent body including a plurality of internally reflective surfaces defining a n-sided base having a polygonal shape and having at least three sides, each reflective surface forming a side of the polygonal shape, the plurality of surfaces configured to direct the electromagnetic radiation beam along a path within the solid transparent body from an entry area to an exit area on the solid transparent body; an electromagnetic radiation source coupled to the entry area on the solid transparent body; and a detector coupled to the exit area on the solid transparent body and configured to receive at least a fraction of the reflected electromagnetic radiation beam, the detector configured to generate a signal based on the received electromagnetic radiation beam and transmit the signal to a processor for at least one of analysis of material characteristics and data storage.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: August 2, 2016
    Assignee: BAKER HUGHES INCORPORATED
    Inventors: Sebastian Jung, Felix Wellmann, Thomas Kruspe
  • Patent number: 9357955
    Abstract: A portable analytical device including at least one optical unit and optionally an adapting device are provided. The optical unit includes a light beam receiving area, a sample holder, a light beam exiting area, and a lens component. The adapting device holds the optical unit and an external hand-held computing device (EHCD), such that the optical unit is coupled to the EHCD.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: June 7, 2016
    Assignee: Industrial Technology Research Institute
    Inventors: Hui-Hsin Lu, Sheng-Po Wang, Mao-Yin Wang, Kuan-Hung Chou, Ching-Kai Peng, Wei-Chin Huang, Yu-Hsuan Liao, Louis Lu-Chen Hsu
  • Patent number: 9140857
    Abstract: Disclosed is a double-sided grating waveguide biosensor. The double-sided grating waveguide biosensor is used to sense the properties of a sample solution. The double-sided grating waveguide biosensor comprises a sequential stack of a plastic grating having a grating part, a waveguide layer having a double-sided grating structure, and a channel chip. Furthermore, the sample solution is guided into the channel chip; the light beam is coupled into the waveguide layer via the double-sided grating structure, propagates in the waveguide layer, and penetrates outward. The double-sided waveguide biosensor detects the properties of the sample solution via a variation of a light beam intensity of the outgoing light beam.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: September 22, 2015
    Assignee: National Chung Cheng University
    Inventors: Wen-Hsin Hsieh, Lai-Kwan Chau, Hsun-Yuan Li, Wei-Chun Hsu
  • Patent number: 9063054
    Abstract: Substrates and methods for in vitro determination of sunscreen protection factors (SPF) are disclosed.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: June 23, 2015
    Assignee: Suncare Research Laboratories, LLC
    Inventors: Joseph W. Stanfield, Joseph William Stanfield, III
  • Patent number: 9041922
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 26, 2015
    Assignee: Alessi Technologies, Inc.
    Inventors: Nolan Orfield, Collin Rich, Vincent Alessi
  • Patent number: 9025152
    Abstract: An absorption cell for microfluidic chemical analysis made from tinted or colored polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the colored polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: May 5, 2015
    Assignee: University of Southampton
    Inventors: Cedric Florian Aymeric Floquet, Hywel Morgan, Vincent Joseph Sieben, Iain Rodney George Ogilvie, Matthew Charles Mowlem
  • Patent number: 9013702
    Abstract: Optical computing devices are disclosed. One optical computing device includes an electromagnetic radiation source that emits electromagnetic radiation into an optical train to optically interact with a sample and at least one integrated computational element, the sample being configured to generate optically interacted radiation. A sampling window is arranged adjacent the sample and configured to allow transmission of the electromagnetic radiation therethrough and has one or more surfaces that generate one or more stray signals. A first focal lens is arranged to receive the optically interacted radiation and the one or more stray signals and generate a primary focal point from the optically interacted radiation. A structural element defines a spatial aperture aligned with the primary focal point such that the optically interacted radiation is able to pass therethrough while transmission of the one or more stray signals is substantially blocked by the structural element.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 21, 2015
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Robert Freese, Christopher Michael Jones, David Perkins, Michael Simcock, William Soltmann
  • Patent number: 9007595
    Abstract: A liquid sample analyzer includes a flow cell, a light source, and a lamp temperature management system. The flow cell is configured to receive a flow of a liquid sample from a liquid sample source. The light source includes a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell. The lamp temperature management system includes: an air flow generator operable to generate a turbulent air flow to cool the lamp; a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary housing and the lamp; and a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow away from the primary housing.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: April 14, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Gregory Hanlon, Timothy Neal
  • Patent number: 9001319
    Abstract: An optical sensor may include a sensor head that has an optical window for directing light into a flow of fluid and/or receiving optical energy from the fluid. The optical sensor may also include a flow chamber that includes a housing defining a cavity into which the sensor head can be inserted. In some examples, the flow chamber includes an inlet port defining a flow nozzle that is configured to direct fluid entering the flow chamber against the optical window of the sensor head. In operation, the force of the incoming fluid impacting the optical window may prevent fouling materials from accumulating on the optical window.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: April 7, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Eugene Tokhtuev, Christopher J. Owen, Anatoly Skirda, William M. Christensen
  • Patent number: 8970837
    Abstract: An apparatus for taking an accurate photometric measurement of a liquid by way of forming a specimen volume of a controlled optical path length for use with photometric measurement equipment is disclosed herein. In some embodiments, the apparatus comprises a transparent body configured for displacing a volume of a fluid and at least one support element wherein the support element is configured to maintain the transparent body at a location such that specimen fluid may enter a void volume to form a specimen volume of a controlled optical path length. In some embodiments, the apparatus comprises a plurality of transparent bodies interconnected by a web such that the transparent bodies are maintained at a spacing arrangement which allows for them to be inserted into the wells of a microplate in order to create a plurality of specimen volumes of a controlled optical path length.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 3, 2015
    Inventor: Congliang Chen
  • Patent number: 8964184
    Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: February 24, 2015
    Assignee: Cytonome/ST, LLC
    Inventors: John R. Gilbert, Edward Sinofsky, Manish Deshpande
  • Patent number: 8941827
    Abstract: Measuring device of the present invention includes a plurality of measuring sites for generating a plurality of optical paths and various dilutions. The range for concentration measurement and the measurement accuracy are enhanced due to the plurality of optical path length, and the interference on the measurement ranges and results caused by the concentration or the turbidity of suspended solid is reduced and removed by water sample dilution, and thus the characteristic wavelengths of the components in the water are measured. Next, the information of spectrum database is used to determine the ingredients which may exist in the water (qualitative analysis), and UV-VIS-NIR absorbance spectrum analysis is used to obtain the concentration of the respective ingredients in the water at the same time (quantitative analysis).
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: January 27, 2015
    Assignee: National Central University
    Inventors: Shu-Liang Liaw, Chien-Ku Chen, Hsin-Yi Wang, Yang-Yu Lin, Chen-Hua Chu, Chih-Chung Chan
  • Publication number: 20150002834
    Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 1, 2015
    Inventors: Alan Marc Fine, Hershel Macaulay, Noah Hymes-Vandermeulen
  • Patent number: 8922778
    Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 30, 2014
    Assignee: EMD Millipore Corporation
    Inventor: Fedor Ilkov
  • Publication number: 20140375997
    Abstract: A method and apparatus to calculate the optical density of a fluid (110) traveling through a narrow gap (30) with a set width. Typically, a densitometer employs a light source (10) that is configured to transmit light across the gap and a detector, opposite the light source (10), configured to detect light transmitted from the light source, across the gap, for calculating the optical density of the fluid. The apparatus and method further include a transparent element (120), the transparent element part of a set of replaceable transparent elements, each replaceable transparent element having a particular width, the width less than the width of the gap. Typically, the transparent element is moved into the gap between the light source and the detector to narrow the effective sampling width of the gap for calculating the optical density of the fluid. In some examples, the transparent element is further configured to rotate in the gap to enhance the flow of the fluid through the gap.
    Type: Application
    Filed: February 8, 2012
    Publication date: December 25, 2014
    Applicant: HEWLETT-PACKARD INDIGO B.V.
    Inventors: Ziv Gilan, Zvi Shemer, Zeharia Levi, Erez Lampert, Niv Shemtov
  • Patent number: 8908179
    Abstract: A cuvette comprising a cuvette wall for limiting a sample reception space for receiving a fluid sample is disclosed. The cuvette wall is adapted to allow a traversal of measurement radiation through the fluid sample situated within the sample reception space. An information presenter is fixed at the cuvette wall. The information presenter wirelessly provides data to be transferred to an external data reception module. The data to be transferred relates to the cuvette. Further, an optical measurement apparatus is described.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: December 9, 2014
    Assignee: Anton Paar GmbH
    Inventor: Martin Ostermeyer
  • Patent number: 8908166
    Abstract: Methods and apparatus for downhole fluid analysis are disclosed. An example method includes obtaining first measurements from a first spectrometer and a second spectrometer when a light source is on, obtaining second measurements from the first spectrometer and the second spectrometer when the light source is off and calibrating the first spectrometer based on the first measurements and the second measurements.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 9, 2014
    Assignee: Schlumber Technology Corporation
    Inventors: Hisatoshi Matsumoto, Hua Chen, Akira Kamiya, Stephane Vannuffelen
  • Patent number: 8891086
    Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: November 18, 2014
    Assignee: Thermo Scientific Portable Analytical Instruments Inc.
    Inventors: Kevin J. Knopp, Robert L. Green, Brendon D. Tower, Christopher D. Brown, Gregory H. Vander Rhodes
  • Publication number: 20140320861
    Abstract: Aspects of the present disclosure include a flow cell nozzle configured to propagate light emitted by a sample in a flow stream upstream by total internal reflectance. Flow cell nozzles according to certain embodiments include a nozzle chamber having a proximal end and a distal end and a nozzle orifice positioned at the distal end of the nozzle chamber where the flow cell nozzle is configured to propagate light emitted from a sample in the flow stream upstream through the flow cell nozzle orifice by total internal reflectance toward the proximal end of the nozzle chamber. Systems and methods employing the subject flow cell nozzles are also provided.
    Type: Application
    Filed: April 23, 2014
    Publication date: October 30, 2014
    Inventors: Gerrit J. van den Engh, Timothy Wayne Petersen
  • Patent number: 8873057
    Abstract: A probe having a probe head in which is formed an opening for receiving a sample to be analyzed, the head comprising a pair of optical interfaces disposed at an opposing inner surface of the opening to delimit a path for optical radiation through the opening, wherein one of the pair of optical interfaces comprises a transparent element adapted to permit optical radiation in one or more wavelength regions of interest to travel between the probe head and the opening, the optical probe comprising a movable diaphragm in which one of the pair of optical interfaces is located for movement therewith and an actuator operably connected to the diaphragm to control its movement so as to vary the path length wherein the probe head comprises a hinge system cooperable with the actuator to move the optical interface in the movable diaphragm in an arc to vary the path length.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: October 28, 2014
    Assignee: Foss Analytical A/S
    Inventor: Christian Born
  • Patent number: 8867039
    Abstract: Example methods and apparatus for obtaining suspended particle information are disclosed. A disclosed example method includes emitting light from a light source, dividing the light source into a first path and a second path, and directing the first path to a first container comprising a plurality of particles in a suspension material. The example method also includes directing the second path to a second container containing a suspension material devoid of particles, retrieving a first transmission value of the first path through the first container, and retrieving a second transmission value of the second path through the second container.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: October 21, 2014
    Assignee: University of Notre Dame du Lac
    Inventors: Steven Ruggiero, Carol Tanner
  • Patent number: 8848193
    Abstract: A laser emitting section 59A and a laser receiving section 59B for measuring an oxygen concentration are provided on two sides of an inspection area so as to be moved toward and away from a bag-shaped container 1. Gas-filled chambers 61 provided on the end faces of the laser emitting section 59A and the laser receiving section 59B are brought into contact with the gas phase portion of the container 1 to keep a constant thickness of the gas phase portion. A tilting device 81 is provided to press the container 1, which is held by a container holder 16, from both sides with a container pressing member 88 and tilts the container 1 in a vertical plane. When an oxygen concentration is measured, the tilting device 81 tilts the bag-shaped container 1 to measure the gas phase portion at the shoulders of the container 1.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: September 30, 2014
    Assignee: Hitachi Zosen Corporation
    Inventors: Takayasu Yokobayashi, Yoshinari Horimoto
  • Patent number: 8826519
    Abstract: The present invention relates to a method and system for repairing and refurbishing a microplate reader of the Flipr type which has a water cooled argon laser light source. The old laser is removed and replaced with a high power (300 to 500 mW) air cooled solid state laser as a replacement place on its own support and focused and wired to replace the old laser. The new product operates at lower power consumption yet provides accurate measurements.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: September 9, 2014
    Inventor: Thomas Leen
  • Patent number: 8823940
    Abstract: Methods and apparatuses for measuring a light absorbance are provided. The method measures light absorbance of at least one detection chamber of a microfluidic device, including the detection chamber and at least one reference chamber. The detection chamber may accommodate a test subject. The method includes detecting a plurality of reference transmitted light intensities for the at least one reference chamber and estimating a value between the plurality of reference transmitted light intensities through nonlinear approximation. The estimated value is then applied to light absorbance measurement of the detection chamber to reduce a light absorbance error of the detection chamber.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: September 2, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Yeong Bae Yeo
  • Patent number: 8823942
    Abstract: An environmental cell assembly for use in microscopy and spectroscopy applications, including: an environmentally sealed body assembly configured to selectively hold and contain a sample; a plurality of ports manufactured into one or more surfaces of the body assembly for one or more of evacuating the body assembly and injecting a gas into or removing a gas from the body assembly; a port manufactured into a surface of the body assembly for receiving a translating stage configured to move the sample within the body assembly; and a port manufactured into a surface of the body assembly for receiving one or more lenses utilized in a microscopy or spectroscopy application; wherein the one or more lenses are disposed adjacent the sample without intervening structures disposed there between. The cell assembly also includes a port manufactured into a surface of the body assembly for retaining a window and providing visualization of the sample.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 2, 2014
    Assignee: Consolidated Nuclear Security, LLC
    Inventors: Ashley Clinton Stowe, Norman Smyrl, Russell L. Hallman, Jr.
  • Publication number: 20140240695
    Abstract: The present disclosure relates generally to systems and methods for determining the absorption coefficient and the optical density of a fluid as they relate to the wavelength of incident radiation. Specifically, ultraviolet light-emitting diodes (UV LEDs) or the like that emit ultraviolet (UV) radiation or the like are used as sources for irradiating the interior of an integrating chamber that is designed to increase the path length of the radiation through the fluid, thus enhancing the detection limits of the absorption coefficient and the optical density according to Beer's Law.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE
    Inventors: Jennifer Godwin Pagan, Edward Brittain Stokes, Paolo Batoni
  • Publication number: 20140233015
    Abstract: A portable, tabletop fluid sampling device simplifies spectral analysis to produce an accurate but inexpensive chromatic fingerprint for fluid samples. In one embodiment, the sampling device uses an array of variable wavelength LED emitters and photodiode detectors to measure Rayleigh scattering of electromagnetic energy from the fluid sample contained in a cuvette. Either the fluid itself, or particles suspended in the fluid can then be identified by performing spectral pattern matching to compare results of a spectral scan against a library of known spectra. A wide range of applications include substance identification, security screening, authentication, quality control, and medical diagnostics.
    Type: Application
    Filed: March 12, 2013
    Publication date: August 21, 2014
    Inventors: Richard Ian Mander, Allan David Beach, Michael Vivian Denton, Tom A. Furness, III, Alan Charles Tompkins
  • Patent number: 8804114
    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: August 12, 2014
    Assignee: Pocared Diagnostics Ltd.
    Inventor: Gal Ingber
  • Publication number: 20140176952
    Abstract: An absorption cell for microfluidic chemical analysis made from tinted or coloured polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the coloured polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.
    Type: Application
    Filed: February 4, 2011
    Publication date: June 26, 2014
    Inventors: Cedric Florian Aymeric Floquet, Hywel Morgan, lain Rodney George Ogilvie, Matthew Charles Mowlem, Vincent Joseph Sieben
  • Patent number: 8760658
    Abstract: A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: June 24, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Gregory Hanlon, Timothy Neal, Richard Edwards
  • Patent number: 8743354
    Abstract: An optical blood monitoring system for blocking unwanted light from reaching sensors in a sensor clip assembly fastened to a blood chamber connected in an extracorporeal blood treatment system. The sensor clip assembly includes opposing heads with LED emitters and photodetectors. In one embodiment, lenses in the heads are surrounded by shrouds extending from the lenses so that when the sensor clip assembly is fastened to the blood chamber the shrouds block unwanted light from reaching the photodetectors. Either alternatively or as a complement to the shrouds, the blood chamber includes an opaque portion or a portion colored to attenuate particular wavelengths of light to further enhance the overall ability of the blood chamber and sensor clip assembly to block unwanted light from reaching the photodetectors.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: June 3, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Louis L. Barrett, Perry N. Law
  • Patent number: 8736834
    Abstract: A modular optical sensor system for fluid media has a measuring module which includes an exchangeable fluid chamber and an exchangeable optic holder. The fluid chamber has an inlet and an outlet as well as a measurement space for the fluid medium. The optic holder has at least one optical transmitter and at least one optical receiver. The optic holder is inserted within the measuring module relative to the fluid chamber in such a way that the radiation emitted by the optical transmitter traverses the measurement space for the fluid medium in the fluid chamber and impinges on the optical receiver.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: May 27, 2014
    Assignee: Buerkert Werke GmbH
    Inventors: Georg Moll, Dominik Rabus, Michael Winkler
  • Patent number: 8724113
    Abstract: A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: May 13, 2014
    Assignees: IMEC, Katholieke Universiteit Leuven
    Inventors: Kai Cheng, Pol Van Dorpe, Liesbet Lagae, Gustaaf Borghs, Chang Chen
  • Patent number: 8708319
    Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 29, 2014
    Assignee: Pall Technology UK Limited
    Inventors: Alexandre N. Terentiev, Sergey Terentiev
  • Patent number: 8709788
    Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 29, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Abbas El Gamal, Helmy Eltoukhy, Khaled Salama
  • Publication number: 20140104617
    Abstract: A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 17, 2014
    Inventors: Gregory Hanlon, Timothy Neal, Richard Edwards
  • Patent number: 8699029
    Abstract: A method and apparatus for detecting trace gas concentrations in the atmosphere. An absorption signal is provided that includes collected sunlight that has undergone absorption by a trace gas. The absorption signal is mixed with laser light at a nearby frequency to the absorption signal. An amplitude of a resulting RF signal is proportional to the concentration of the trace gas.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: April 15, 2014
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics Space Administration
    Inventors: Emily W. Steel, Matthew L. McLinden
  • Patent number: 8699031
    Abstract: An optical measurement device is adapted to measure characteristics of a measurement targeted fluid based on a transmitted inspection light. The device comprises a cell having an internal space for accommodating the measurement targeted fluid to flow therein and having a pair of opposing through holes for transmitting the inspection light, each of the through holes sealed with a transparent member. The device includes a projection optical system member having a port for projecting the inspection light and a light-receiving optical system member having a port for receiving the inspection light transmitted through the internal space. A base member is provided for supporting the cell, the projection optical system member, and the light-receiving optical system member in a configuration with gaps between the cell and the respective optical system members to accommodate movement in a predetermined range along a direction perpendicular to an optical axis of the inspection light.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: April 15, 2014
    Assignee: Horiba, Ltd.
    Inventors: Kimihiko Arimoto, So Takagi
  • Patent number: 8692988
    Abstract: Micro cuvette assembly for examining biological samples has a first partial plate with one or more first cuvette surfaces and a second partial plate opposite the first and which also has one or more second cuvette surfaces. In an active position of the assembly, the second cuvette surfaces are arranged parallel and in register with the first cuvette surfaces and are spaced apart from the first cuvette surfaces whereby one or more micro cuvettes are formed. The first and second partial plates also have openings arranged in register with the cuvette surfaces and transparent bodies are provided as the cuvette surfaces. The first and second plates are completely penetrated by these openings and the transparent bodies are manufactured from a different material than the partial plates and span the openings close to a first surface of the partial plates.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: April 8, 2014
    Assignee: Tecan Trading AG
    Inventors: Walter Gotschy, Josef Grassel, Fritz Payr, Markus Schürf
  • Publication number: 20140092376
    Abstract: A system and method for the in-line analysis of protein-containing compositions for protein denaturation. The system and method employ providing a protein-containing composition in a container that can be directly used in an analytical method for evaluating the denaturation of a protein. The container can be directly employed in an analytical technique such as UV spectroscopy, circular dichroism, etc.
    Type: Application
    Filed: October 1, 2012
    Publication date: April 3, 2014
    Applicant: MOMENTIVE PERFORMANCE MATERIALS, INC.
    Inventors: Guangjun XU, Robert Koch, Madhuri Raju, Simon Williams