Abstract: Optical cells are non-actively compensated to ensure that a sample gap of a sample space remains nearly constant upon a change in temperature. Fluids can be flowed through the sample space of the optical cells.

Abstract: A measuring chamber for photo-acoustical sensors for the continuous measurement of radiation-absorbing substances, in particular of radiation-absorbing particles, in gaseous samples includes at least one entry and at least one exit for the samples, a tube section with microphone that allows for the flow-through of the sample in longitudinal direction, and at least one entry and exit point for a laser beam that is aligned with the tube section, and whereby these entry and exit points are both arranged at a distance from the measuring tube by at least one chamber with a cross-sectional area that is expanded relative to the tube section.

Abstract: A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell.

Abstract: The contents of a liquid medium are determined using a light source and an optical detector, for example a spectrometer. A longitudinally displaceable piston sucks the medium into a cylindrical glass measuring chamber and evacuates the liquid from the chamber. At least one measuring beam is directed through the medium, and at least one reference beam is directed outside the medium. The piston has cleaning/sealing rings mounted on its outer periphery which rub against an inner surface of the glass measuring chamber as the piston travels, to clean the surface.

Abstract: A method for in-situ monitoring of an emission product includes transmitting a light, tuning the light to a first wavelength, receiving the light at a second location, varying the light from the first wavelength to a second wavelength during a first period, measuring a first absorption line and a first non-absorbing baseline signal during the first period, switching the light to a third wavelength, varying the light from the third wavelength to a fourth wavelength over a second period, and measuring a second absorption line and a second non-absorbing baseline signal during the second period. The light is transmitted from a first location by a tunable light source and received at a second location. The light passes along an optical path through the emission product between the first and second locations. The first wavelength corresponds to the first absorption line of the emission product. The third wavelength is different from the first and second wavelengths.

Abstract: An optical system is provided for achieving enhanced rejection of scattered excitation light and superior signal-to-noise performance when reading microplate wells. The optical system uses an axial configuration in which the excitation beam incident upon the sample propagates along the axis of the microplate well. Excitation light from a light source, such as a lamp or fiber optic bundle, is collimated into a beam using a lens. A reflective pick-off mirror is then used to reflect the collimated excitation beam upward along the well axis. A focusing lens, with a diameter exceeding the diameter of the collimated excitation beam, is used to focus the excitation beam in the well. The same broad lens is used to collimate the emitted fluorescent light, of which a large percentage propagates axially past the pick-off mirror towards a second focusing lens that focuses the emission beam onto the face of a fiber optic bundle.

Abstract: An apparatus utilizes miniaturized surface plasmon resonance (SPR) and ion-selective self-assembled monolayer (SAM) and hydrogel chemistry to measure metal ion concentrations in liquids. The SPR optical system is packaged in a compact and cost-effective form factor. An electronic circuit drives the optical system. The SPR system utilizes an optical window that is coated with the SAM layer or hydrogel material. The SAM layer and hydrogel materials are highly selective to a specific metal ion of interest. The miniaturized SPR sensor is situated in an optical-fluidic cell or an optical-fluidic manifold with the SAM layer or hydrogel material in contact with the liquid. Metal ions selectively attach to the SAM layer or hydrogel material, thereby affecting the SPR signal. Changes in the SPR signal are used to accurately determine the metal ion concentration in the liquid. The liquids may be either static or dynamic.

Abstract: An absorptiometry microchip testing device with which, after one-time startup, test results of blood analyses are automatically obtained without a special tester. The microchip testing device has a rotary drive source which can be stopped at a prescribed angle; a centrifugal rotor connected to the rotary drive source via the main shaft; a direction switching mechanism for controlling the main shaft gear; a planetary gear which engages the main shaft gear which is located on the centrifugal rotor; a chip holder which turns together with the planetary gear; a microchip which is held in the chip holder and has a part for measuring absorbance; a light source from which light is incident in the absorbance measuring part of the microchip; a detector which receives light transmitted by the absorbance measuring part; and a controller which controls movements of the rotary drive source and the direction switching mechanism.

Abstract: A multiple pass optical cell and method comprising providing a pair of opposed mirrors, one cylindrical and one spherical, introducing light into the cell via an entrance mechanism, and extracting light from the cell via an exit mechanism, wherein the entrance mechanism and exit mechanism are coextensive or non-coextensive.

Abstract: A spectroscopy cell has a body with a central outer sample chamber (6). Within this chamber (6) is a sample cavity (25) as part of a temperature controlled sample probe (23). At one end this sample cavity (25) is delimited by a movable gas connection insert (20) which extends outwardly to a temperature-controlled (e.g. cooled) end plate (8). Gas inlet and outlet tubes (29,30) also extend from the end plate to the sample cavity (25). In use the sample cavity (25) may be at a high temperature so that (a) it is difficult to provide seals for the gas connection insert (20) and gas tubes (29,30); and (b) they are subject to considerable thermal expansion and contraction. Similar problems occur with very low cavity temperatures. Therefore compressible seals (21,31,32) are provided in the end plate (8), remote from the chamber.

Abstract: A sample cell, which is a component of a gas monitoring system, includes a sample cell body and a sample cell core installed therewith. The sample cell is coupled to a sampling tube that communicates with an airway of a patient. Gas from the sampling tube passes through the sample cell such that the flow profile remains substantially undisturbed. Within the sample cell, at least one optical aperture permits radiation to be emitted, pass through the gas in the sample cell core, and detected. In this manner, measurements of the partial pressure or concentration of a gas of interest are determined.

Abstract: The invention proposes a spectroscopic device and a spectroscopic method, comprising a tubular measuring cell, in particular, for absorption spectroscopy of contaminated carbon dioxide, wherein the measuring cell is stabilized using at least one tube which is disposed parallel to the direction of extension of the measuring cell and is rigidly connected to the measuring cell.

Abstract: A system and method employing optical disc drives for quantitative analysis of physical, chemical and biochemical parameters are provided. The system includes a robotic arm for transmitting a disc including at least one sensor spot through a variety of stations that include dipping the disc into a source of a compound, removing excess amounts of the source, optically scanning the disc, and discarding the disc. The optical drive may be a stand-alone reader in communication with an external computing device. The output of the optical scan may be transmitted from the optical scanner to the computing device via universal serial bus, Ethernet interface, or wireless connection.

Abstract: A microstructure-based chemical sensor that can be interrogated by a remote observer. The device acts as an electromagnetic wave filter in the optical region of the spectrum, filtering one or more wavelength bands where the band spectral notch location shifts in response to the accumulation of material on the surface of the microstructure sensor. The apparatus has a substrate having a surface relief structure containing dielectric bodies with one or more physical dimensions smaller than the wavelength of the filtered electromagnetic waves, such structures repeated in an array covering at least a portion of the surface of the substrate. A retro-reflecting structure allows interrogation of the sensor over a wide field of view. The device is particularly useful as a water monitoring device in hard to reach locations, and as a chemical warfare or explosives detector that can be read from a safe distance.

Abstract: A system for identifying a gas sample includes a canister, a docking station, a thermal desorption device, and a spectrometer. The canister includes a sorbent and a valve. The docking station is configured to removably engage the canister. When the canister is engaged with the docking station, the canister is capable of fluid communication with a gas cell via the valve.

Abstract: An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical blocks having a plurality of grooves for positioning and aligning the capillary column with the one or more excitation fibers, and a plurality of lens seats for optically coupling the lens element with the capillary column. Each block includes a male and female part for mating the two identical blocks together.

Abstract: An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

Abstract: An apparatus and method for analyzing liquid samples employs first and second bidirectional ports that permit liquids to be introduced to first and second liquid waveguide capillary cells at the same time. The direction of liquid flow through the apparatus and roles of components may be reversed to prevent or overcome obstruction by particulates and other debris. The apparatus and method can detect and map colored dissolved organic matter and can detect, discriminate and map algal species or algal blooms including red tide in an automated, unattended manner within large aquatic systems.

Abstract: An NIR spectroscopy fluid analyzing system using a series of LED's, each having its own preselected center wavelength, as illumination sources. These wavelengths have overlapping spectral widths, such that the measurement covers a broad spectrum. The LED's illuminate the fluid sample sequentially, and subsequently the transmission absorbance through the sample and the reflectance or scattering from the sample is measured for the wavelength range of each LED. The measurements are performed using photodetectors. The concentrations of component parts of the fluid are expressed in the form of a polynomial, which is a function of the measured transmitted and/or reflected intensities, and of empirical coefficients, which are extracted by prior statistical analysis on measured intensities obtained from a large number of test samples having known concentrations of the component. A novel sample chamber, capable of performing optical absorption measurements on a flowing sample of fluid, is described.

Abstract: This invention relates to a multi-component absorbance monitor, and the object is to provide a general-purpose and highly accurate compact absorbance monitor. Disclosed is an absorbance monitor including a light source, a sample cell and a plurality of detectors as elements, wherein a light collecting member is arranged between the light source and one detector, and an inside wall of the light collecting member has a site for guiding a part of light from the light source, that is, a light guiding opening, and light from the light guiding opening enters another detector. Preferably, the light collecting member lies between the light source and the sample cell. Preferably, an optical element used for another detector described above is arranged in the light guiding opening and adjacently to a light path formed by the light collecting member.

Abstract: An absorption spectroscopy apparatus including a sample cell having a central axis, and a side wall coaxially positioned about the axis. The side wall defines a generally circular cross-section of the cell as taken along a plane extending perpendicular to the axis, wherein the generally circular cross-section of the sample cell has an average radius. The side wall includes a plurality of light reflective segments arrayed about the axis, wherein each reflective segment has a cross-section taken along a plane extending perpendicular to the axis of the cell that is concave with respect to the axis. The concave cross-section of each segment has an average radius that is unequal to the average radius of the generally circular cross-section of the sample cell. Among other aspects and advantages, the apparatus of the present disclosure is able to use incoherent, non-collimated light sources while maintaining high optical throughput efficiencies.

Abstract: A fluid inspection device for inspecting a fluid in a vessel includes an elongate insertion well having a rear end disposed at the wall of the vessel and a front end disposed in the interior of the vessel. An inside of the insertion well is sealed off from the fluid in the vessel and an outside of the insertion well is in contact with the fluid in the vessel. A camera unit is disposed in the inside of the insertion well, and a lens in operative communication with the camera unit is disposed at the front end of the insertion well so that a front end of the lens is in contact with the fluid and a rear end of the lens is inside the insertion well. In addition, a light guide having a light emitting end is configured to guide light from the inside of the insertion well to the light emitting end.

Abstract: An optical flow is disclosed having a shell with a first portion and a second portion. The first portion provides a light entry aperture, and the second portion provides an imaging aperture. An inlet tube and an outlet tube are retained between the first portion and the second portion. A viewing assembly is retained between the first portion and the second portion. The viewing assembly includes a reference plate and a flow channel. The flow channel fluidly communicates with the inlet tube and the outlet tube. The reference plate extends from the shell to serve as a repeatable reference point for properly positioning the optical flow cell.

Abstract: Novel nanowell microarrays are disclosed in optical contact with polymer waveguides wherein evanescent field associated with lightwaves propagated in the waveguide excite target substances in the nanowells either by a common waveguide or by individual waveguides. Fluid samples are conveyed to the nanowells by means of microfluidics. The presence of the target substances in fluid samples is detected by sensing fluorescent radiation generated by fluorescent tag bound to the target substances. The fluorescent tags generate fluorescent radiation as a result of their excitation by the evanescent field. One or more PMT detectors or a CCD detector are located at the side of the waveguide opposite to the nanowells. Fluorescent radiation is detected due to its coupling with the waveguide or its emission through the waveguide.

Abstract: A system and method employing optical disc drives for quantitative analysis of physical, chemical and biochemical parameters are provided. The system including a disc drive for supporting and rotating an optical disc including at least one sensor spot; a light source for directing light onto the sensor spot; at least one optical pickup for detecting light transmitted from the sensor spot, the transmitted light being indicative of a concentration of a compound; and an analog-to-digital converter for quantifying an intensity of the transmitted light. The method comprising the steps of preparing the optical disc with a plurality of sensor spots, the sensor spots being responsive to a compound; exposing the optical disc to a fluid; measuring intensity of transmitted light from at least one of the plurality of sensor spots; and correlating the measured intensity of transmitted light to an amount of compound exposed to the optical disc.

Abstract: The invention simplifies the apparatus for the analysis of organic and inorganic compounds in solutions and atmospheres, or particulates in atmospheres. The apparatus supports molecular fluorescence and absorption analyses of trace environmental contaminants. The design of the apparatus allows for deployment within the confines of a monitoring well or other locations of limited access. The primary advantages are the easy replacement and configuration of excitation sources and detectors to configure a sample chamber for a particular analysis while using mininal volumes of sample or reagent. Miminizing the volume of reagent used is a very important consideration in automated field analyses. The invention uses light emitting diodes (LEDs) and photodetectors coupled to fiber optics to reduce the complexity and cost of the optics and electronics of the measurement components.

Abstract: An optical waveguide is constructed so as to comprise a non-solid core layer surrounded by a solid-state material. The non-solid core layer has an index of refraction which is lower than the index of refraction of the surrounding solid-state material, and light can be transmitted with low loss through the non-solid core layer. In an exemplary application, the non-solid core layer comprises a sample material whose light transmission, absorption, and/or interference characteristics are to be measured. In addition, a perpendicular waveguide portion may be included for use in injecting light into the core for measuring fluorescence characteristics associated with the sample material. Most preferably, the optical waveguide is generally structured as an anti-resonant reflecting optical waveguide (ARROW), which comprises a Fabry-Perot reflector adjacent to the core layer, whereby light is substantially prevented from leaking out of said core in a transverse direction.

Abstract: A method of “reading” the result of an assay effected by concentrating a detectable material in a comparatively small zone of a carrier in the form of a strip, sheet or layer through the thickness of which electromagnetic radiation such as visible light is transmissible, wherein at least a portion of one face or the carrier is exposed to incident electromagnetic radiation which is substantially uniform across the entire portion, the portion including the small zone, and electromagnetic radiation emerging from the opposite face of the carrier is measured to determine the assay result. Preferably the radiation is diffuse light.

Abstract: The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

Abstract: An apparatus for cavity enhanced optical detection having an improved flow cell is provided. Sensitivity of the cavity resonance condition to changes in refractive index of an analyte flowing through the flow cell is reduced. More specifically, the round trip optical path defined by the resonant cavity intersects a curved cavity input mirror at a point. This point has a location on the input mirror that is substantially independent of the refractive index of the analyte. In this manner, changes in sample refractive index do not lead to misalignment of the resonant optical cavity.

Abstract: An apparatus and method for analyzing an impurity in a liquid. The apparatus comprises a cell coupled to a light source and a detector. The cell includes a first mirror at a first end of the cell to receive and pass the light into the cell along a longitudinal axis of the cell, and a second mirror at a second end of the cell to at least partially reflect the light. A liquid supply device projects a stream of the liquid between the first mirror and the second mirror and across the longitudinal axis of the cell. The detector is coupled to the second end of the cell and determines a decay rate of the light within the cell based on the light passing through the liquid.

Abstract: Method and system for causing a powder sample in a sample holder to undergo at least one of three motions (vibration, rotation and translation) at a selected motion frequency in order to present several views of an individual grain of the sample. One or more measurements of diffraction, fluorescence, spectroscopic interaction, transmission, absorption and/or reflection can be made on the sample, using light in a selected wavelength region.

Abstract: An apparatus for intended use in measuring, sensing, or detecting a characteristic of a fluid, such as a liquid food product, is disclosed. The apparatus includes a body having a pocket for positioning adjacent to the opening in a pipe or like structure for receiving a portion of a fluid therein. In one possible use, a first optical medium, such as an optical fiber, transmits light from a source toward a portion of the fluid flow entering the pocket. Light received by one or more optical mediums positioned in backscatter, sidescatter, or transmission configurations relative to the first optical medium is detected by a corresponding sensor or detector. Using the output of this sensor or detector, an optical characteristic of the fluid may be measured. An overall system using the apparatus and related method for detecting an optical characteristic of a fluid are also disclosed.

Abstract: A container to be positioned in a ring-down optical cavity for containing a sample includes an outer surface having opposing first and second outer faces and an inner surface forming a void for containing the sample and having opposing first and second inner faces. The container may include a first portion forming the first outer face having a second index of refraction and a second portion forming the second outer face having a third index of refraction. The container may be placed in an optical cavity including a medium. The first and second outer faces of the outer surface and the first and second inner faces of the inner surface are oriented so that the cavity-to-container interfaces and the container-to-sample interfaces of the container transmit and receive a light beam at an incidence angle approximately equal to the Brewster's angle of the respective interface.

Abstract: The invention relates to a transmission sensor (1) for measuring the turbidity of a fluid, comprising a first and a second measuring section (2, 3). A transmitter (6) emits electromagnetic radiation into the two measuring sections (2, 3). A first receiver (14) is allocated to the first measuring section (2) and a second receiver (15) is allocated to the second measuring section (3). The transmitter (6) is inserted into a transmitter carrier (8) in such a way that the transmitter (6) is forced to adopt a predetermined oriented position. The receivers (14, 15) are inserted into a receiver carrier (18) in such a way that each of said receivers (14, 15) is forced to adopt a predetermined oriented position. A transmitter carrier holder (9) forcibly positions the transmitter carrier (8) in a predetermined location and a receiver carrier holder (19) forcibly positions the receiver carrier (18) in a predetermined location.

Abstract: The invention concerns a method for the optical analysis of a fluid, in which the fluid that has a first refractive index, is surrounded by an auxiliary fluid with a second refractive index, the first refractive index being larger than the second refractive index and light being sent through the fluid. It is endeavoured to obtain an encapsulation of the fluid in the auxiliary fluid at low cost. For this purpose, firstly the auxiliary fluid is led into a measuring channel, until it is filled, and then lead the fluid into the auxiliary fluid within the cross section with a flow speed, which generates a parabolic flow profile.

Abstract: Combining the approaches of cavity ring down spectroscopy with surface plasmon resonance spectroscopy allows creation of an ultra-high sensitivity apparatus to detect extremely low concentrations of chemicals and biomolecules.

Abstract: An enclosure for a cavity enhanced optical spectroscopy instrument provides a highly temperature stable environment by positioning the instrument optical cavity away from the enclosure walls and providing a wall mounted heat pump, fan and heat exchanger. The fan causes the gas contained within the enclosure to circulate over the heat exchanger and in a laminar, non-turbulent flow path along interior wall surfaces of the enclosure thereby maintaining the optical cavity in a temperature and vibration stable zone.

Abstract: Purging of a light beam path in an effective manner that minimizes the affect of the purging requirement on system throughput. In one embodiment, the invention is incorporated into a birefringence measurement system that has several components for directing light through a sample optical element and thereafter detecting and analyzing the light. The segment of the beam path through the sample is isolated to reduce the volume that requires continual purging.

Abstract: Disclosed is a counting chamber for optical detection of particles that are present in a fluid, comprising two substantially transparent and substantially parallel plates of material, between which the fluid can be introduced. At least one of the plates includes a visible reference, which comprises a relief formed on the surface of the plate.

Abstract: The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

Abstract: Methods and apparatus for simultaneous or sequential, rapid analysis of multiple samples by photoacoustic spectroscopy are disclosed. Particularly, a photoacoustic spectroscopy sample array vessel including a vessel body having multiple sample cells connected thereto is disclosed. At least one acoustic detector is acoustically positioned near the sample cells. Methods for analyzing the multiple samples in the sample array vessels using photoacoustic spectroscopy are provided.

Abstract: An apparatus and method for carrying out analysis of samples using semi-reflective beam radiation inspection in association with an optical disk and an optical reader has an optically transparent substrate having a semi-reflective layer which reflects a portion of the beam of light to form a reflected beam and transmits a portion of the beam of light to form a transmitted beam. The semi-reflective layer includes optically readable encoded information to be read by the reader for controlling the scanning of the reader relative the disk, the encoded information providing modulation of the reflected beam. The disk includes a sample support surface positioned to be scanned by the reader on which the biological, chemical or biochemical sample may be located for optical inspection with the transmitted beam.

Abstract: The present invention is a sample holder for spectrum measurement settable in a measuring chamber of a spectrophotometer and being used for measuring a spectrum of a liquid sample, which comprises a holding block (11) having a hole (111) and a light introducing path (112) being provided crosswise, and a light introducing path position adjusting means (12) being located under the holding block (11), said the light introducing path position adjusting means (12) comprising a light introducing path horizontal direction position adjusting means (12-1) and/or a light introducing path vertical direction position adjusting means (12-2), for adjusting so as to the irradiation light is introduced into the liquid sample by aligning a position of the light introducing path (112) with a propagating route of the irradiation light for spectrum measurement, said the holding block (11) further comprising a device for controlling a temperature of said liquid sample.

Abstract: A method for conducting laser absorption measurements in high temperature process streams having high levels of particulate matter is disclosed. An impinger is positioned substantially parallel to a laser beam propagation path and at upstream position relative to the laser beam. Beam shielding pipes shield the beam from the surrounding environment. Measurement is conducted only in the gap between the two shielding pipes where the beam propagates through the process gas. The impinger facilitates reduced particle presence in the measurement beam, resulting in improved SNR (signal-to-noise) and improved sensitivity and dynamic range of the measurement.

Abstract: The invention relates to a gas cell (1) adapted for carbon dioxide and including a cavity (10) which is adapted for a chosen gas volume, a light s source (11) and a light-bundle receiving unit (12). The light source (11) is placed in a focal point (F) associated with a partially elliptical mirror surface (13) forming a reflector for the light source (11) and a first defining surface of the cavity (10). Two other cavity-defining surfaces are comprised of gas-conducting surfaces (14a, 14b) orientated from the end-parts (13a?, 13b?) of the mirror surfaces (13a, 13b). The light-bundle receiving unit (12) is placed in a second focal point (F?) associated with the partially elliptical mirror surfaces (13a, 13b).

Abstract: An apparatus, a sample cuvette and a method for optical measurements on samples which show variable levels of scattering are provided. The apparatus, sample cuvette and method may be used for optical measurements on biological, physiological and chemical samples, however, are especially applicable for optical measurements on whole blood.

Abstract: An apparatus for measuring decay in intensity of electromagnetic radiation passing through a radiation-absorbent sample due to absorption of radiation by the sample is disclosed which includes a source of electromagnetic radiation having a wavelength within an absorption band of the sample and a plurality of partially-reflective specular surfaces which are spaced apart from each other along a predetermined path through the sample, each specular surface separating the incident radiation into a reflected part which follows the predetermined path and an unreflected path, the value of the decay being derived from intensity measurements of the unreflected parts made at different positions along the predetermined path.

Abstract: Disclosed are system and method for characterizing a system consisting of a fluid sample on a two sided stage, utilizing data obtained by applying, from both sides thereof, beams of electromagnetic radiation to a fluid coated surface in a containing cell volume. The beams can have the same or different wavelength content and/or polarization state, and can be applied at the same or different magnitude angles-of-incidence, and a third typically unpolarized beam can be applied at a normal angle-of-incidence.

Abstract: The invention relates to a cell for an ophthalmic lens, for testing the latter with an optical inspection system, said cell comprising a hollow space (11, 31) which is filled with a liquid and has an axis (12, 32) coinciding, in the test position, with the optical axis of an inspection system and, in the test position of the cell, is delimited from above by a viewing glass (13, 33) for the optical test and has, underneath the viewing glass, a test trough (14, 34) for the ophthalmic lens.