Abstract: An apparatus having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a hand-holdable or implantable miniaturized and portable cytometer instrument. This cytometer has significant application in biological warfare agent detection, hematology and other clinical and research fields.

Abstract: An optical multi-pass cell (100) is provided. The optical multi-pass cell (100) includes a housing (101). The housing (101) defines a sample cavity (109) for receiving a sample under test. The optical multi-pass cell (100) also includes first and second end mirrors (103, 104) positioned within the housing (101). The first and second end mirrors are separated by a distance, L, and face one another coaxially to an optical axis (113) that extends between the first and second end mirrors (103, 104). The first and second mirrors (103, 104) are configured to reflect a beam of light directed at one of the first or second end mirrors (103, 104) off-axis from the optical axis (113) one or more times between the first and second end mirrors (103, 104) through the sample cavity (109) at a first distance from the optical axis (113) to create a first beam pattern (330).

Abstract: A sample analyzer includes a loading section in which a measuring unit is removably set, the measuring unit being adapted to receive a sample; and a control section which analyzes a signal acquired from the sample received in the measuring unit set in the loading section to provide a result of analysis of the sample; wherein the control section judges whether or not the measuring unit is properly set in the loading section.

Abstract: The invention relates to a modular absorption measuring system (1) for fluid media comprising a detection module (2) and a sample module (3), which comprises a sample chamber (14). The detection module (2) comprises a detection system (5), which also comprises an electromagnetic radiation source (8) and a quantum detector (9). The radiation source (8) is designed for supplying light in the direction of the sample chamber (14) and the quantum detector (9) is designed for receiving light from the sample chamber (14). The electromagnetic radiation source (8) is designed as an electroluminescence component and the detection module (2) and the sample module (3) are also designed to be arranged on top of one another.

Abstract: The present invention relates to a transmission liquid flow cell capable of high rates of liquid flows regardless of the optical pathlength of the cell. This increase in the cell's internal flow rate is provided by an internal bypass created around the circumference of the windows. The high rate of internal flow of liquid around the circumference of the windows and in direct contact with the liquid between the windows provides a push-pull action that urges the flow of liquid through the gap between the windows. The faster the circumferential flow, the stronger the push-pull action. The cell is used for the measurement of the absorption of light passing through a liquid sample contained in the gap between the cell's windows.

Abstract: A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within the read station, a housing and shield eliminates light leakage from the sample under test. In addition, the read station regulates the intensity of the light by providing an attenuation capability.

Abstract: An apparatus for monitoring a position of a semiconductor process fluid interface in a dispense nozzle includes an extended optical source adapted to provide an optical beam propagating along an optical path. The optical beam is characterized by a path width measured in a first direction aligned with a dispense direction. The apparatus also includes an optical detector coupled to the optical path and adapted to detect at least a portion of the optical beam and a dispense nozzle disposed along the optical path at a location between the extended optical source and the optical detector. The apparatus further includes a nozzle positioning member coupled to the dispense nozzle and adapted to translate the dispense nozzle in the first direction.

Abstract: An automatic analysis apparatus and an automatic analysis method that can perform both spectrophometric measurements for biochemical tests and the turbidimetric immunoassay with high precision by selectively exchanging a white light or at least one monochromatic light based on analysis conditions determined by a measure condition setting unit for respective measuring object. The automatic analysis apparatus includes an irradiating direction setting unit configured to irradiate the selected white light or at least one monochromatic light based on the analysis conditions onto a reaction cuvette along the same light axis and a light detection unit having a plurality of light receiving elements in order to detect the white light of particular determined wavelength lights and the selected monochromatic light.

Abstract: A process monitoring system determines a spectral response of a process material. This system has a tunable laser for generating an optical signal that is wavelength tuned over a scan band and an optical probe for conveying the optical signal to the process material and detecting the spectral response of the process material. The optical probe expands a beam of the optical signal to a diameter of greater than 10 millimeters. This avoids one of the difficulties with monitoring these process applications by ensuring that the spectroscopy measurements are accurate and repeatable. It is desirable to sample a relatively large area of the processed material since it can be heterogeneous. Additionally the large area mitigates spectral noise such as from speckle.

Abstract: A system for spatially selective, fixed-optics fluorescence detection in a multichannel polymeric microfluidic device, and a method for performing spatially selective, fixed-optics fluorescence detection.

Abstract: A device for the photometric examination of samples has a sample-holder apparatus for at least two sample vessels, and a measuring apparatus and a moveable apparatus. The sample-holder apparatus is designed to be stationary, and the measuring apparatus is arranged on the moveable apparatus such that it can be displaced by means of the moveable apparatus.

Abstract: A position detector is for detecting a position of liquid held in a vessel. The position detector includes a sound wave generator disposed in contact with the vessel and having a plurality of sound generating elements for generating a sound wave by electrical energy; and a measuring unit that measures electrical characteristics of each of the sound generating elements based on the electrical energy reflected from each of the sound generating elements. The position detector also includes a determining unit that determines the presence or absence of the liquid at a position of each of the sound generating elements based on difference in the electrical characteristics measured at the measuring unit.

Abstract: The device and the method are used for optical detection of at least one phase transition between at least two media, which are taken into a line and/or dispensed from the line by an intake and/or dispensing device. A light-emitting transmitter emits light across and onto the line at a measurement point provided for this purpose. A receiver receives the emitted light, which is influenced by media in the line, to form reception signals. At least one waveguide, which is arranged up to the measurement point on the probe, is provided between the transmitter and/or the receiver and the measurement point (M). Due to the fact that the waveguide is arranged in parallel to the line at least in the area near the probe and at least one deflection lens is provided in the area of the measurement point to deflect the light emitted and/or the light to be detected, a phase boundary or state can be detected, and the dead volume is reduced.

Abstract: This analyzer comprises a photoirradiation portion simultaneously photoirradiating a plurality of storage vessels storing a plurality of measurement samples respectively and a plurality of photodetection portions detecting a plurality of light components resulting from simultaneous photoirradiation on the plurality of storage vessels storing the plurality of measurement samples respectively. The photoirradiation portion includes a light source, a first light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively and a second light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively.

Abstract: The present invention relates to a miniature apparatus for analyzing urine components and a method for real-time analyzing urine components using the same which can measure and analyze components contained in the urine in real-time.

Abstract: Optical cells include a spacer formed of a hydrocarbon-resistant polymer, so that fluids such as hydrocarbons and alcohols can be introduced to a sample space, or include a fluid inlet and a heated inlet tube, so that a humid gas can be introduced to the sample space without condensation occurring. Optical cells can be used with, for example, solid, gel, and liquid samples. Measurements can be performed with various selected sample gaps of an optical cell.

Abstract: The present invention concerns a measurement chip (1) for carrying out measurements of transmission and/or emission and/or scattering of light by a fluid sample in an operator unit, wherein the measurement chip has a base plate (2) produced from a transparent polymer material, provided in the base plate (2) are at least one measurement cell (3) for receiving a fluid sample and fluid passages (4, 4) for supplying and discharging fluid to and from the measurement cell (3), and provided in and/or on the base plate (2) outside the measurement cell (3) are mirror surfaces (5) which are so arranged that they direct light emitted from and/or scattered by a fluid sample in the measurement cell (3) from the measurement chip (1), preferably in the direction of a light detector provided in an operator unit.

Abstract: A method of detecting a level of anesthetic agent in an anesthesia vaporizer is disclosed. The anesthetic agent forms a column of liquid within an external indicator; the method projects a beam of light into the external indicator. The method further receives the beam of light after the beam of light has traveled through the column of liquid, and detects when the level of anesthetic agent drops below a predetermined level.

Abstract: The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.

Abstract: A common multi-gas ring down detector incorporates a cavity that has a piezoelectric mirror and at least two displaced mirrors to define two different transit paths in the cavity. The two paths intersect at the piezoelectric mirror at different angles. Two different laser beams having first and second different wavelengths, can be coupled to the cavity, at different times, by driving the piezoelectric mirror axially. Beam outputs can be evaluated to establish the presence of selected gases in the cavity.

Abstract: The invention relates to a pipe system comprising a) a pipe, b) a fluid sensing station and c) a remote light detector system. The pipe comprises a flow channel and an annular fluid cavity surrounding the flow channel. The fluid sensing station comprises a sensing fluid cavity which is in fluid communication with the annular fluid cavity, and the sensing fluid cavity comprises a light emitter and a light receiver placed at a distance from each other. The light emitter and the light receiver are optically connected to each other and optically connected to the remote light detector system. The invention also relates to a fluid sensing system for sensing a fluid in an annulus cavity of a pipe, said fluid sensing system comprises a fluid sensing station and a remote light detector system. The fluid sensing station comprises a sensing fluid cavity comprising a light emitter and a light receiver placed at a distance from each other and optically connected to each other.

Abstract: A gas sensor for measuring at least one gas concentration, in particular for a vehicle climate control system, having a substrate, an IR radiation source fastened on the substrate, an IR detector fastened on the substrate, a measurement chamber for receiving a gas having the gas concentration that is to be measured, a shielding device situated in the measurement chamber between the IR radiation source and the IR detector, for shielding a direct transmission of IR radiation from the IR radiation source to the IR detector along an optical axis, and a reflective surface that has a concavely curved first mirrored area for receiving the IR radiation emitted by the IR radiation source, and that has a concavely curved second mirrored area that reflects the IR radiation to the IR detector, the measurement chamber being formed between the reflective surface and the substrate.

Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

Abstract: An optical sensing system includes an optical sensor that includes a substrate having an upper surface and a plurality of tapered walls on the substrate, wherein at least one of the tapered walls is aligned along a longitudinal direction, wherein the plurality of tapered walls comprise sloped surfaces oriented at oblique angles relative to the upper surface, wherein the sloped surfaces are configured to adsorb molecules of a chemical sample, a light source configured to emit an incident light beam to impinge the plurality of tapered walls adsorbed with molecules of the chemical sample; and a detector that can collect light scattered by the plurality of tapered walls to allow a determination of the sample chemical.

Abstract: High resolution particle differentiation process and separation system that provides enhanced resolution of particles based upon selected particle characteristics. In particular, the system may include an enhanced resolution flow cytometer. In an embodiment, the invention can include at least one fluid source conduit (24) that introduces 0 fluid source stream (24) into an enhanced resolution nozzle (25) at an angle that enhances particle resolution by the cell sensing system (13).

Abstract: The present invention relates to a sealable cell for measuring a liquid sample comprising a spectroscopic probe and a removable cap that can accommodate at least the head of the probe, wherein the internal wall of the cap comprises one or more grooves which are disposed so as to allow a liquid sample to enter the head of the probe and air to escape from the head of the probe to enable improved spectra to be obtained.

Abstract: In a spectrophotometer for measuring transmitted light of a trace liquid sample, four sample holders 12 are provided on a disk-like sample plate 11 while spaced apart by 90 degrees. The sample plate 11 is driven to rotate so that each of the sample holders 12 is sequentially moved to a sample supply position U1, a measuring position U2, a wiping position U3 and a waiting position U4. At the sample supply position U1, a trace amount of the liquid sample is dropped into a groove of the sample holder 12. Then at the measuring position U2, a window plate 22 is lowered onto the groove so as to determine the optical path length. Next, measurement of the transmitted light is performed. Further, while the sample holder 12 moves from the measuring position U2 to the waiting position U4, the liquid sample is absorbed and removed by contact with a cleaning pad 26. The liquid sample attached to the window plate 22 is wiped out by another pad.

Abstract: An automatic analysis apparatus and an automatic analysis method analysis that includes an optical convergence point adjusting unit in order to variably adjust an optical convergence point of irradiation light or an optical convergence point of detection light to or from a reaction cuvette in accordance with at least one of analysis conditions of a kind of reaction of a mixed solution contained in the reaction cuvette, a liquid volume of the mixed solution or a measurement wave length. The optical convergence point adjusting unit is provided in front the reaction cuvette, in back of the reaction cuvette, or both in order to variably control the position of an optical convergence point so as to maximize the irradiation light based on the volume of the mixed solution in the reaction cuvette.

Abstract: A transparent tube is used as the fluid pathway of a flowthrough cell, which not only makes sure the fluid can retain the stable laminar state without micro-bubble existing, but also can avoid the turbulent state and the micro-bubbles that produce the negative peak and the interference peak. Utilizing the transparent property of the pipe wall, the outer wall of both ends of the optical pathway is made to be a smooth plane and forms a single unit planar light inlet window with the pipe. The cell does not need to be furnished with a glass window or a quartz glass window any more. This design has solved the leakage and dead angle problems. The invention not only simplifies the structure but also increases the precision.

Abstract: A fiber-optic probe includes first and second optical fibers disposed in a body, a liquid sampling region between ends of the fibers and a reflector, and apertures communicating with the sampling region. The probe may be inserted in media in a vessel. Optical signals are transmitted through the first fiber, the sampling region and second fiber. The sampling region is offset from other parts of the probe so that bubbles or particulates flow out from the sampling region without being obstructed by the probe.

Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.

Abstract: A method and a device are presented for measuring the mercury content of hydrocarbon and natural gases in a continuous mode and in-situ in a gas production line in a real time mode, comprising diverting a gas sample from the gas production line in an optical flexible measuring cell for optical detection of the mercury present in the gas production line.

Abstract: An ultrasonic optical cleaning system is provided for cleaning and deterring the buildup of organic and inorganic particulates from the surface of glassware used in water testing instrumentation. The ultrasonic optical cleaning system includes a transducer that is attached to the surface of the glassware. A connector cap carrying a plurality of spring contacts interconnecting the transducer with an ultrasonic transducer control circuit. The control circuit operates continuously to provide an electrical signal to the transducer that vibrates the transducer and the glassware so that the glassware is cleaned of contaminates.

Abstract: This disclosure relates generally to a sampling device, and, more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms, and methods for using such a device.

Abstract: A testing device equipped with: a microchip having a receiver for a test fluid, a discharge lamp which emits light into the microchip test fluid receiver, a light source housing in which the discharge lamp is located, and an arithmetic calculation mechanism, which calculates the concentration of the component to be detected, based on the intensity of the light emitted from the test fluid container unit. To reduce the size of the device and to shield the arithmetic calculation mechanism from electromagnetic waves generated around the light source, the light source housing is equipped with shielding connected to the ground on the outside of the light source housing made of insulating material. The light source housing is positioned within an enclosure of the testing device holding the microchip and containing the arithmetic calculation mechanism, analysis output device(s), and other components of the testing device.

Abstract: An automatic optical measurement system (100) is provided. The measurement system (100) includes a sample vial (10) and an automatic optical measurement apparatus (90) configured to receive the sample vial (10). The automatic optical measurement apparatus (90) is configured to detect a presence of the sample vial (10) in the automatic optical measurement apparatus (90) and measure a light intensity of light substantially passing through the sample vial (10) if the sample vial (10) is present. The measured light intensity is related to sample material properties of a sample material within the sample vial (10).

Abstract: Provided is a method of adjusting detection sensitivity in detecting a sample in a channel. A detection method of optically detecting a sample includes: forming a multilayer flow, in which at least one of layers of the multilayer flow contains the sample; introducing light into at least one of layers of the multilayer flow; and detecting a signal generated from the multilayer flow in response to the introduced light, to detect the sample. The sample includes one of a chemical substance, a molecule, a cell, a particle, and a mixture thereof. At least one of fluids included in the multilayer flow has a refractive index different from a refractive index of another one of the fluids.

Abstract: An optical cell and a method of operating an optical cell comprising employing a first mirror comprising a first hole therein at approximately a center of the first mirror and through which laser light enters the cell, employing a second mirror comprising a second hole therein at approximately a center of the second mirror and through which laser light exits the cell, and forming a Lissajous pattern of spots on the mirrors by repeated reflection of laser light entering the cell.

Abstract: A flow chamber, imaging objective, condenser and imaging light source as part of an optical system includes an oil-immersion objective and high numerical aperture condenser matched to a rectangular flow chamber. The oil-immersion objective and flow chamber include a high index of refraction immersion oil so as to enhance the optical resolution and optical coupling therethrough. The imaging light source generates light which passes through the condenser, the flow chamber and then the objective before being focused onto an imaging camera. Fluorescence excitation passes through the objective to the flow chamber where the oil immersion configuration enhances the focus and collection of the light back through the objective.

Abstract: A system that employs transmission-based detection techniques to determine the presence or concentration of an analyte within a test sample is provided. Specifically, the optical detection system contains a chromatographic-based assay device that is positioned in the electromagnetic radiation path defined between an illumination source and detector. To enhance the sensitivity and signal-to-noise ratio of the system without significantly increasing costs, the distance between the illumination source and/or detector and the assay device is minimized. The illumination source and/or detector may also be positioned directly adjacent to the assay device. In addition, the system may be selectively controlled to reduce reliance on external optical components, such as optical filters or diffusers.

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample.

Abstract: An optical apparatus and method comprising a light source, an array detector for area imaging and an optical cell assembly. The optical cell assembly comprises a chamber which is arranged to receive a sample of a material including an analyte, a fluid inlet and a fluid outlet coupled to the chamber. A fluid dissolution medium stream passes through the chamber such that the sample can dissolve into the dissolution medium. The chamber is in at least one light path created between the light source and the array detector. The array detector comprises a two dimensional array of detector locations arranged to provide an output signal indicative of the light absorbance of the analyte within the chamber such that the output of the array detector is indicative of the concentration profile of the analyte near the surface of the sample.

Abstract: A microfluidic analysis system for optically analyzing a substance includes a light source having a plurality of selectable single-wavelength light sources, a substance presentation member optically coupled to the light source, and an optical detection system associated with the substance presentation member.

Abstract: This absorption spectrometric apparatus for semiconductor production process includes a flow passageway switching mechanism connected to a discharging flow passageway of a processing chamber for a semiconductor production process and a multiple reflection type moisture concentration measuring absorption spectrometric analyzer that allows a laser beam from a laser light source to undergo multiple reflection within a cell, detects a light absorbancy change by a gas within the cell, and measures a moisture concentration within the gas. The flow passageway switching mechanism connects the discharging flow passageway by switching between a measuring flow passageway through which the gas is discharged by passing through the cell and a bypass flow passageway through which the gas is discharged without passing through the cell.

Abstract: Disclosed is a particle density measuring probe for measuring the density of atoms or molecules in a plasma atmosphere by absorption spectroscopy. The probe has a cylindrical light guiding member provided in the plasma atmosphere. At the front end of the light guiding member, there is provided a reflection plate for reflecting light that has propagated through the cylindrical light guiding member. Behind the reflection plate, in a cross section perpendicular to the longitudinal direction of the light guiding member, a part devoid of a portion of wall surface is provided by a predetermined length in the longitudinal direction. A plasma introducing portion allows mutual contact between light passing through this part devoid of a portion of wall surface and atoms or molecules in the plasma atmosphere. The probe has a main body that guides light in an axial direction by total reflection by a side wall, and that is located behind the plasma introducing portion.

Abstract: A flow metering device and method for monitoring flow of a liquid, has a body with an inlet port and an outlet port. A flow chamber is formed therein between a pair of laterally placed windows in the flow chamber. A light emitting source placed in one of the windows and a light receiver placed in a second of the windows. The flow chamber has a flow restricting and light stopping element held therein and movable between a rest position and an operating position.

Abstract: A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample. The waveguide sample holder can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light coming out of the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, and one or more optical detectors. The waveguide sample holder has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light coming out of the bottom of the waveguide sample holder.

Abstract: Improved optical alignment precision to a passive optical cavity is provided by including a combination of a weak focusing element and a translation plate in the input coupling optics. Adjustment of positions and angles of these optical elements, preferably after all other input optical elements are fixed in place, advantageously provides for high-precision optical alignment to the cavity, without requiring excessively tight fabrication tolerances. Fabrication tolerances are relaxed by making the optical power of the weak focusing element significantly less than the optical power of a strong focusing element in the input optics. The position and angles of the beam with respect to the cavity can be adjusted, as can the size of the beam at the cavity. Differential adjustment of the beam size in two orthogonal directions (e.g., tangential plane and sagittal plane) at the cavity can also be provided.

Abstract: An absorption spectroscopy apparatus including an elliptical mirror centered on the midpoint between a source/detector and a mirror. The cavity between the elliptical mirror and the source/bolometer and mirror defines an interior volume of a sample cell. Electromagnetic radiation from the source/detector travels along a multi-segment path starting from the source/bolometer toward the elliptical mirror, reflecting off of the elliptical mirror and traveling toward the mirror, reflecting off of the mirror and traveling back toward the elliptical mirror and finally reflecting off the elliptical mirror for a second time and returning toward the source/bolometer. The multiple reflections combined with the focusing effects of the elliptical mirrored surface result in an efficient sampling device. Among other aspects and advantages, the apparatus of the present disclosure is able to use incoherent, non-collimated light sources while maintaining high optical throughput efficiencies.

Abstract: An apparatus for measuring an absorption coefficient includes a first diffusive material, a second diffusive material inside the first diffusive material separated from the first diffusive material by a cavity, and a transparent material proximate to an inner surface of the second diffusive material that holds an absorptive material. First and second light detectors measure light intensities in the first and second diffusive materials cavity and the transparent material respectively. An absorption coefficient for the absorptive material may be determined based on the first and second light intensities measured when the cavity is illuminated by a light source.