Means Separating Or Dissolving A Material Constituent Patents (Class 422/255)
  • Patent number: 7303733
    Abstract: The present invention concerns a gas/liquid(s) separation system constituted by three different sections: a primary separator (1) for flows with a G/L in the range 0.1 to 10; a secondary separator (2) for flows with a G/L in the range 10 to 50; a system (3) which limits the formation of a liquid vortex; where G/L is the ratio of the gas to liquid mass flow rates.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: December 4, 2007
    Assignee: Institut Francais du Petrole
    Inventors: Christophe Boyer, Abdelhakim Koudil, Thiery Gauthier
  • Patent number: 7300636
    Abstract: A single housing comprising a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein said reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: November 27, 2007
    Assignee: Prismedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 7270792
    Abstract: A process and a system for increasing para-xylene production from a C8 aromatic feedstream by coupling at least one xylene isomerization reactor with at least one pressure swing adsorption unit or temperature swing absorption unit to produce a product having a super-equilibrium para-xylene concentration. This product is then subjected to para-xylene separation and purification.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: September 18, 2007
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Harry W. Deckman, Ronald Richard Chance, James Alexander McHenry, John Di-Yi Ou, Juan José Reinoso
  • Patent number: 7201290
    Abstract: A method and apparatus for dispensing of a product based on weight as a load cell (22) which supports a structure holding the product (20a) to be dispensed. The weight of the product (20a) that is dispensed is determined by use of a controller (23).
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: April 10, 2007
    Assignee: Ecolab Inc.
    Inventors: Richard J. Mehus, John E. Thomas, Thomas J. Batcher
  • Patent number: 7179435
    Abstract: The invention relates to an apparatus for the purification of a substance from a solution, a suspension or a mixture of liquids by crystallization, preferably in a continuous manner. The apparatus comprises a first crystallizer (1c) comprising an input (1) for receiving a liquid comprising the substance and an output (4) for discharging a slurry of liquid and crystals. The apparatus comprises also a first separator (1s) connected to the output 4 of the first crystallizer (1c) having a product output (2), and being with a residue output (5) connected to an input of a second crystallizer (2c), and a second separator (2s) being with an input connected to an output (6) of the second crystallizer (2c), a crystal output (7) of the second separator (2s) being connected to an input of the first crystallizer (1c).
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: February 20, 2007
    Assignee: Niro Process Technology B.V.
    Inventors: Ray Sircy Ruemekorf, Reinhard Uwe Scholz
  • Patent number: 7172739
    Abstract: A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or chemical properties; (b) contacting the fluid with at least two individual polymer matrix units, each polymer matrix unit preferentially accepting a different set of polypeptides on the basis of one or more physical and/or chemical properties; and (c) extracting the set of polypeptides from each polymer matrix unit.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: February 6, 2007
    Assignee: University of Vermont and State Agricultural College
    Inventor: David W. Maughan
  • Patent number: 7032847
    Abstract: The invention concerns a method for treating tyres, belts, inflatable boats, boots and other manufactured articles containing rubber, polymers and reinforcing elements, which is a close circuit system consisting in immersing the waste materials to be treated in a hot alkaline hydroxide bath, followed by neutralization of the resulting materials with a weak mineral acid solution for industrial re-use of said materials.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: April 25, 2006
    Inventor: Gérard Debailleul
  • Patent number: 7008599
    Abstract: A filtration assembly operable in connection with a crystal form screening workstation that provides for automated crystal form screening is disclosed. The assembly includes first and second valves, with each valve having an internal passage and first, second and third ports. A filter line is interposed between the first and second valves in fluid communication with the second port of the first valve and the second port of the second valve. A filter medium is in disposed in or at the end of the filter line and adapted to filter a drug-containing suspension flowing through the filter line. The filter medium is operable to filter fluids under both positive and negative pressure conditions.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: March 7, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: David Leroy Carlton, Om Parkash Dhingra, David Harlan Igo, Phillip William Waters
  • Patent number: 6986872
    Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: January 17, 2006
    Assignee: Prismedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6967002
    Abstract: A method and apparatus for producing a sterile medical solution is disclosed. The method includes providing at least two components, a first component including bicarbonate ions and a second component including glucose or calcium ions, preheating the first component to a first temperature and the second component to a second temperature, heat sterilizing the first and second components separately to a third and fourth temperatures respectively, the third and fourth temperatures being sterilizing temperatures for the first and second components, maintaining the first and second components approximately at their respective third and fourth temperatures, so as to sterilize the first and second components, cooling the first and second components and delivering the first and second components to a mixing device.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: November 22, 2005
    Assignee: Gambro Lundia AB
    Inventors: Raymond Anthony Edgson, Michael John Dunkley, Richard J. Hammond, Eric Wilkinson
  • Patent number: 6942844
    Abstract: Silane is produced in a continuous process by disproportionating trichlorsilane in at least 2 recreation areas for reaction/distillation, which are run through by a countercurrent of steam and liquid in the presence of catalytically active solid under a pressure which ranges between 500 mbar and 50 bar.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: September 13, 2005
    Assignee: Solarworld Aktiengesellschaft
    Inventors: Dirk Müller, Georg Ronge, Johannes-Peter Schäfer, Hans-Joachim Leimkühler, Ulrike Strauss, Hans-Dieter Block
  • Patent number: 6884390
    Abstract: A system and method are disclosed for applying a corrosion inhibiting material to an article. The method includes the steps of depositing a layer of corrosion inhibiting material onto a carrier film, applying the corrosion inhibiting material to the article, and separating the carrier film from the at least a portion of the corrosion inhibiting material. In a preferred embodiment, the corrosion inhibiting material is applied to rotors of disc brakes in new automotive vehicles.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: April 26, 2005
    Assignee: FLEXcon Company, Inc.
    Inventors: Frank McConville, Richard Skov, John R. Pennace
  • Patent number: 6878283
    Abstract: Filter cartridge assemblies and housings are provided and include a tubular housing having an inner wall, an outer wall, a first end, and a second end. The housings include inner walls with shoulders or other radially-inwardly extending flow directors at the intersections of adjacent sections of the tubular body. The assemblies include a plurality of filter media sections within the housing, and each of the plurality of filter media sections preferably has a different filter media composition. One or more of the filter media sections traverses one or more of the shoulders or other radially-inwardly extending flow directors such that the flow directors evenly direct the flow of fluid through the assembly. The assemblies find particular applicability in dialysis systems.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: April 12, 2005
    Assignee: Renal Solutions, Inc.
    Inventor: Ralph P. Thompson
  • Patent number: 6867049
    Abstract: The present invention relates to a method and apparatus for analyzing a blood or other biological fluid sample in a quiescent state, whereby particulate constituents of biological samples that contain sparse populations of interesting cellular species can be enumerated and inspected using an optical scanning instrument. Specifically, this invention relates to a method and apparatus for obtaining increased cellular or particulate concentrations within the use of said optical scanning method.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: March 15, 2005
    Assignee: Becton, Dickinson and Company
    Inventors: Brian G. Scrivens, Dwight Livingston, Robert S. Frank, Klaus W. Berndt
  • Patent number: 6858139
    Abstract: A single housing comprising a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein said reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: February 22, 2005
    Assignee: Prismedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6830737
    Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: December 14, 2004
    Assignee: Alkermes Controlled Therapeutics Inc. II
    Inventor: J. Michael Ramstack
  • Patent number: 6824750
    Abstract: A vertical extending liquid/liquid contacting column is disclosed, which column will, when in use, contain a dispersed and a continuous liquid phase, the column having a first liquid feed inlet in the top, a first liquid outlet in the top, a second liquid feed inlet in the bottom, a second liquid outlet in the bottom and a plurality of internal trays axially spaced from each other in the column, each tray provided with a plurality of perforations for the passage of the dispersed phase and more than one downcomer or upcomer for the transport of the continuous phase, wherein the downcomer or upcomer extends respectively below or above the tray and wherein the walls of the downcomer or upcomer are inclined towards each other in the flow direction of the continuous phase. A method of use within the column is also disclosed.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: November 30, 2004
    Assignee: Shell Oil Company
    Inventor: Jose Luis Bravo
  • Patent number: 6773668
    Abstract: A solid detergent dispenser for use with a dishwashing machine includes a chamber and a lid. The chamber is configured and arranged to receive a solid detergent having a particular composition. A water inlet receives water from a water source, and the water flows through a tunnel into the bottom of the chamber. The chamber is flooded with water from the bottom to ensure relatively constant erosion of the solid detergent, which ensures that a relatively constant concentration of the solid detergent is used in the dishwashing machine. A water outlet allows water to flow out of the chamber into the dishwashing machine. The water must flow into the chamber faster than it flows out of the chamber to ensure that the appropriate amount of dissolution of the solid detergent occurs. The only valve used in the preferred embodiment is a valve to control the amount of water flowing into the water inlet.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: August 10, 2004
    Assignee: Ecolab, Inc.
    Inventors: Terrence P. Everson, Lee M. Monsrud, Michael P. Kremer, Edward D. Sowle
  • Publication number: 20040120851
    Abstract: The present invention provides a mixture and method for remediating air dispersed biological particles. The mixture contains a carrier, an active biocidal ingredient, and a deliquescent which are mixed, heated and then grinded into biocidal particles approximately 1-50 microns in size. The biocidal particles are then dispersed into the air infected with biological particles using an aerosol generator and similar device. The biocidal particles may be charged to attract the biological particles and the carrier assists in attaching to the biological particles. Upon exposure to ambient humidity the deliquescent dissolves and allows the active biocidal ingredient to react creating a chemical byproduct which attacks and remediates the biological particles. The present invention may utilize two mixtures with two separate active biocidal ingredients which react with one another to create the desired chemical byproduct such as chlorine dioxide. The chemical byproduct may be hydrogen peroxide.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Inventor: James Aamodt
  • Patent number: 6749818
    Abstract: A cost effective solution preparing apparatus includes a chamber which is divided into two compartments by a movable partition; a dissolving solution supply line for supplying a dissolving solution to the first compartment of the chamber; a solution tank connected with the first compartment and the second compartment through a first solution preparing line and through a second solution preparing line, respectively; a transporting pump provided in the second solution preparing line; a concentration meter; a solution transporting line for transporting the solution prepared and filled in the second compartment to a point of use; and a circulating line, in which the solution tank is exemplified as a U-shape tank constructed of a relatively small-diameter upstream tank portion and a relatively large-diameter downstream tank portion, and at least one filter is provided in a downstream portion of the downstream tank portion.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: June 15, 2004
    Assignee: Nipro Corporation
    Inventors: Yoshihiko Sano, Hidetoshi Saio
  • Patent number: 6719954
    Abstract: A multi-stage counter-current crystallization apparatus for crystallizing and subsequently separating a component in pure form from a solution comprises a first concentration stage for forming crystals in the solution and a first crystallization vessel for further growth of the crystals to obtain a first crystal suspension mixture containing larger crystals and first separating means for separating the larger crystals from the first crystal suspension mixture to form a concentrated mother liquor. A second concentration stage forms crystals in the concentrated mother liquor solution and includes a second crystallization vessel for further growth of the crystals. A bypass conduit circulates the crystal suspension mixture in a crystal-growing vessel, and includes a filter for extracting part of the mother liquor solution from the crystal suspension mixture.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: April 13, 2004
    Assignee: Korporam B.V.
    Inventor: Halbe Anne Jansen
  • Patent number: 6710142
    Abstract: There is provided a method for extracting a gaseous fluid which comprises extracting the gaseous fluid through fluid extraction ports set up on the top face portion of a vertical-type agitation tank equipped inside with an agitator, wherein two fluid extraction ports are set up at positions approximately symmetrical about the center of the top face portion of the vertical-type agitation tank, or wherein at least three fluid extraction ports are set up each at a vertex of an approximately regular polygon having the central point identical with the center of the top face portion of the vertical-type agitation tank.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: March 23, 2004
    Assignee: Idemitsu Petrochemical Co., Ltd.
    Inventors: Yasunobu Kaneko, Takamichi Matsumura, Tomoo Nambu, Itaru Matsuhiro
  • Patent number: 6637257
    Abstract: A method and device for performing fluid analysis by separating cells and/or particles from a fluid, such as a biological, vehicular or industrial fluid. The device is a micromachined filtering device comprising a substrate with through-thickness vias having approximately equal diameters that prevent passage through the substrate of a first material while permitting passage through the substrate of other materials having diametrical dimensions less than the diameter of the vias. Electrodes are located on a surface of the substrate between vias so that as the first material collects at the surface of the substrate, the electrodes become electrically connected to produce an output signal in some proportion to the amount of the first material collected. The device can incorporate multiple micromachined substrates, yielding an analysis system that produces an electrical output for each of a number of properties or parameters.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: October 28, 2003
    Assignee: Integrated Sensing Systems
    Inventor: Douglas Ray Sparks
  • Patent number: 6623709
    Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: September 23, 2003
    Assignee: PrISMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6605214
    Abstract: A single housing includes a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein the reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 12, 2003
    Assignee: Prismedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6605258
    Abstract: A liquid chemical stripping or cleaning solution is selected by combinatorial high throughput screening. A high throughput screening well array assembly includes (A) a metal substrate and (B) a mask that defines an array of wells on the substrate. A combinatorial high throughput screening system includes (A) a metal substrate and (B) a mask that defines an array of wells on the substrate and a reaction vessel to receive the well array assembly.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: August 12, 2003
    Assignee: General Electric Company
    Inventors: John Robert LaGraff, Xiao-Dong Sun, James Anthony Ruud, James Claude Carnahan
  • Publication number: 20030147792
    Abstract: A water-soluble and non-water-soluble materials separation device has multiple stirring zones and multiple precipitation zones alternately arranged with the multiple stirring zones. Baffles are respectively provided between the stirring zones and the precipitation zones. Guiding plates are respectively and spatially located in the device to guide solution flow to a center of the baffle. Extraction pipes are provided in the precipitation zones so as to allow formation of precipitation to be collected in the concentration zone. The precipitation is collected from a bottom outlet in the collection tank.
    Type: Application
    Filed: February 5, 2002
    Publication date: August 7, 2003
    Inventors: Ming-Hui Chou, Li-Jung Chu
  • Publication number: 20030127386
    Abstract: This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.
    Type: Application
    Filed: June 21, 2002
    Publication date: July 10, 2003
    Inventors: David C. Bomberger, Pablo E. Garcia, Eric Hegwer, Thomas P. Low, Ripudaman Malhotra
  • Publication number: 20030120112
    Abstract: The object of the present invention is to provide a method to suppress changes the concentration of (meth)acrylic acid in the bottom solution discharged from the absorption column, and to enable stable operation for separating and purifying (meth)acrylic acid in the subsequent steps onward.
    Type: Application
    Filed: November 27, 2002
    Publication date: June 26, 2003
    Inventor: Harunori Hirao
  • Patent number: 6576460
    Abstract: The present invention relates to a filtration-detection device for detecting or quantifying an analyte in a test sample including a filtration device having a first binding material immobilized thereto, wherein the first binding material is capable of binding to a portion of the analyte, and a detection assembly positioned relative to the filtration device to detect or quantify analyte bound to the first binding material. The present invention also relates to methods of using the filtration-detection device.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: June 10, 2003
    Assignees: Cornell Research Foundation, Inc., Innovative Biotechnologies International, Inc.
    Inventors: Antje J. Baeumner, Richard A. Montagna
  • Patent number: 6562307
    Abstract: The present invention relates to an apparatus for the simultaneous analysis of at least two samples by the field-flow fractionation method, where the apparatus has at least the following elements: a) a source of a defined liquid stream, preferably a pump, b) at least two separation channels, each with at least one inlet and each with at least one outlet for passing the at least two samples through in each case one of the at least two separation channels, c) at least one controllable unit which is connected to the at least two separation channels via their at least one outlet each, and which can pass on the at least two samples, which can be passed through in each case one of the at least two separation channels, separately from one another to at least one unit downstream of the controllable unit.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: May 13, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Schuch, Wolfgang Schrof
  • Patent number: 6555056
    Abstract: A method of preserving two or more separately packaged agents for forming a silicone composition which can be cured by mixing the separately packaged agents, which method can reduce the number of air bubbles contained in a cured product of the silicone composition and prevent a reduction in the strength of the cured product. The method of preserving the composition is characterized by keeping each packaged agent of the curable silicone composition under reduced pressure.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: April 29, 2003
    Assignee: Tokuyama Corporation
    Inventors: Hiroyuki Nakagawa, Toshio Kawaguchi, Yasuhiro Hosoi
  • Patent number: 6544400
    Abstract: A hydrogen source system delivers a controlled fuel stream to applications, using wicking to control the contact between a mixture of NaBH4, NaOH and H2O and a hydrolyzing catalyst to create a feedback mechanism to automatically maintain a constant pressure production supply of hydrogen. A small compact device packaged for storage, the system operates in any orientation and is mobile. The system is a small portable packaged hydrogen generator for small fuel cells to power applications that are currently powered by batteries. These packaged devices have higher energy per unit mass, higher energy per unit volume, are more convenient for energy users, environmentally less harmful, and less expensive than conventional power sources.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: April 8, 2003
    Assignee: Manhattan Scientifics, Inc.
    Inventors: Robert G. Hockaday, Patrick S. Turner, Marc D. DeJohn, Carlos J. Navas, Heathcliff L. Vaz, L. Luke Vazul
  • Publication number: 20030050522
    Abstract: A method for operating a dimerization reactor that receives a hydrocarbon feed and produces an output stream comprising a light hydrocarbon component, a dimer and an alcohol component comprises: (a) separating the first output stream into a top stream containing the light hydrocarbon and a bottom stream containing the dimer, with the alcohol being present in the top stream or the bottom stream or both; (b) contacting at least one of the bottom and top streams with a water stream so as to extract at least a major portion of the alcohol therefrom, thereby forming an water/alcohol stream; (c) contacting the water/alcohol stream with a hydrocarbon stream so as to extract at least a major portion of the alcohol present in the water/alcohol stream into the hydrocarbon stream, thereby forming an alcohol-enriched hydrocarbon stream; and (d) feeding the alcohol-enriched hydrocarbon stream into the dimerization reactor.
    Type: Application
    Filed: September 5, 2002
    Publication date: March 13, 2003
    Applicant: Fortum Oyj
    Inventors: Matti Nurminen, Ronald Birkhoff, Anand Subramanian
  • Patent number: 6521195
    Abstract: Multi-phase extraction apparatus comprising two chambers forming a partition stage. Said chambers are connected by connection channels in their upper and lower portions. The upper portion of the first chamber is connected to the lower portion of the second chamber, while the upper portion of the second chamber is connected to the lower portion of the first chamber.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: February 18, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventor: Artak Eranosovich Kostanian
  • Patent number: 6509187
    Abstract: The present invention refers to a device and a procedure for the collection and initial preparation of tissue/blood or other sample of nucleated or DNA-containing cells or cell components for molecular genetic investigation. The invented device for the collection and initial preparation of samples of DNA-containing cells includes a sample receiving container and means for the collection of the sample, which is introduced into the sample receiving container after collection of the sample and seals this tightly. The sample receiving container has a base and side walls, is closed with a easily penetrable lid and has—in an area of the side walls of the container removed from the base—means to secure the introduced sample collection tool; in the container are substances to protect from DNA-degrading enzymes.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: January 21, 2003
    Assignee: Agrobiogen GmbH
    Inventor: Gottfried Brem
  • Patent number: 6485649
    Abstract: Input water is preheated in a heat exchanger (2), pumped (4) through another heat exchanger (5) into a heating unit (6). The heating unit heats the water to a temperature of above 100° C., preferably 140-150° C., while maintaining the water in a liquid state without vaporization. A pump (8) feeds the heated water under sufficient pressure to prevent vaporization to at least one crossflow filtration unit (9). A portion of the heated water passes through a thermally stable filtration material having a pore size of 1-20 nanometers for filtering endotoxins and pyrogens, 4-10 nanometers for filtering viruses, or 100 nanometers−30 &mgr;m for filtering bacteria. Heated water which has passed through the filtration material is fed through a pure water product outlet of the filtration unit to a pure water outlet (16). A retenate portion of the heated water flows past the filtration material to carry filtered impurities through a retenate output line (10).
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: November 26, 2002
    Assignee: Steris Europe, Inc.
    Inventors: Jorma Terävä, Teppo Nurminen
  • Publication number: 20020169345
    Abstract: This invention relates to methods and systems for extracting hydrocarbon gases from hydrates, and more particularly relates to methods and systems for maximizing the efficiency of energy transfer of electromagnetic (EM) radiation of specified frequencies to the hydrate mass and the dissociation of methane and other trapped hydrocarbon gases from their hydrate cages through a unique EM-induced collective molecular vibronic process.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 14, 2002
    Applicant: Supercritical Combustion Corporation
    Inventor: Keith H. Johnson
  • Patent number: 6479277
    Abstract: A method of disrupting biological material includes drying particulate material, mixing the material with a gas under pressure, releasing the pressure explosively and collecting the resultant product. The biological starting material is any particulate material and includes: cells with membranes, cells with rigid cell walls, non-cellular biological material, intra-cellular material, and unbounded homogenous material. Apparatus for batch, semi-continuous and continuous operation of the method is provided. Included is a chamber with at least one inlet valve and at least one outlet valve and collection means. The chamber is capable of withstanding at least 800 bar, preferably 30 bar pressure. The particle size of the starting material is in the range 0.1 to 2000 &mgr;m and of the resultant product, less than 2 &mgr;m.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: November 12, 2002
    Assignee: Cellular Improvements Ltd.
    Inventor: Kelvin Winston Duncan
  • Patent number: 6454103
    Abstract: Multi phase extractor, comprising an extraction chamber, a washing chamber and a re-extraction chamber, said chambers each having inlets adapted to disperse and discharge a phase therein, and connecting channels adapted to convey a continuous phase from said extraction chamber to said washing chamber, from said washing chamber to said re-extraction chamber from said re-extraction chamber to said extraction chamber, and each of said chambers having drains for removing the phase discharged into it by said inlets.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: September 24, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Bäcker, Artak Eranosovich Kostanian
  • Patent number: 6451270
    Abstract: The present invention is a brine-maker of a two-tank arrangement specifically designed for efficient removal of salt sludge. The first tank is a salt-hopper into which water flows from the bottom and up through salt to form brine and leaves mineral impurities called sludge on the bottom of the hopper. The brine then overflows through strainers into a brine containment tank. The outside of the salt hopper has bracketing means attached. When the sludge needs to be removed, a lifting device is attached to the bracketing means and the hopper is disconnected from the water supply by a quick-fit coupler and removed to a dumping site where it is turned on its side and the sludge is poured out. The salt hopper is then returned to its position and coupled to the water supply. The salinity level of the brine in the containment tank can be adjusted either by adding fresh water or by running the brine back through the salt in the salt hopper. The brine is stored in the brine containment tank until discharged for use.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: September 17, 2002
    Assignee: Sprayer Specialties, Inc.
    Inventors: Mark Killian, Scott Killian, Robert Killian
  • Patent number: 6436722
    Abstract: Invention performs an assay to determine presence or quantity of specific analyte in fluid sample. Representative device has two separate flow paths established sequentially in device with a single user activation step. First flow path delivers sample, and conjugate soluble binding reagents to solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. Sample volume delivered by first path determined by absorbent capacity of solid phase, and not by amount of sample added to device. User need not measure sample volume. Sample/conjugate mixture is prevented from entering second flow path because capillary and surface energy of second flow path prevent it from being wetted by this mixture. Second flow path allows wash reagent to remove unbound conjugate and sample from solid phase to the absorbant, and optionally deliver detection reagents.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: August 20, 2002
    Assignee: Idexx Laboratories, Inc.
    Inventors: Scott M. Clark, Robert H. Suva, Michael R. Kepron, Stanislaw Barski, Jr., Erwin F. Workman, Jr.
  • Patent number: 6426055
    Abstract: Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1 up to about 150 microns, having entrapped and dissolved therein molecules of at least one fragrance substance capable of evolving from said film into the environment proximate said film by means of molecular diffusion at a permeation rate of from about 1×10−7 up to about 0.1 mg-mm/cm2-min in a sustained and controlled release manner. Also described is a process for using the aforementioned system for imparting a fragrance into the environment above the unobstructed outer surface of the aforementioned polymer film which is coated on the surface of a solid or semi-solid support, e.g., a solid surface or human epidermis.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: July 30, 2002
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Adi Shefer, Shmuel David Shefer, John M. Teffenhart
  • Patent number: 6426056
    Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: July 30, 2002
    Assignee: PRISMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6391654
    Abstract: A kit for testing male fertility comprises a vessel, a base unit, a liquid supply containing liquid and two filters. The first filter is a sample separation filter which forms a hindrance to transmission of spermatozoa. The second filter of the kit is a spermatozoa detection filter comprising a reagent for identifying spermatozoa. Activation of the kit is prevented until a transport medium, such as the liquid, fills a gap allowing spermatozoa to transmit to a detection zone. The kit may be of one-piece construction and utilizes a thin piece of filter material to separate motile from non-motile spermatozoa.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: May 21, 2002
    Assignee: Genosis Limited
    Inventor: Paul North Bateman
  • Patent number: 6384090
    Abstract: The invention relates to a process and an apparatus for preparing active ingredient dispersions, wherein an active ingredient is dissolved in a fluid gas, the fluid gas loaded with active ingredient is essentially completely dissolved in a liquid and is decompressed, and the gas is separated from the liquid loaded with active ingredient.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: May 7, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Thomas Riede, Werner Göbel, Christian Lockemann
  • Patent number: 6361749
    Abstract: Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium in a reaction chamber which incorporates baffles, a spinner, a stirrer, or a plunger operable to be displaced along a collection surface to define a narrow flow path through which the particle-laden test medium must flow. The collection surface is a thin-walled non-magnetic material having a plurality of magnetic pole faces positioned therearound. Test medium within a reaction chamber is caused to flow past a collecting surface, and a high-gradient magnetic field is applied to the surface to capture magnetically responsive particles in the test medium. The particles are deflected toward the collection surface in the flow path for the test medium. The narrow flow path assures that substantially all of the particles pass within the high-gradient magnetic field along the collection surface.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: March 26, 2002
    Assignee: Immunivest Corporation
    Inventors: Leon M. M. Terstappen, Gerald V. Doyle, Paul A. Liberti, Gerald J. Dolan
  • Patent number: 6274103
    Abstract: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: August 14, 2001
    Assignee: PrISMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6245207
    Abstract: A cell separation module for separating and collecting cells having a charge and cells having no charge comprises a holder and a throwaway cell separation chamber held by the holder. Ultrasound is introduced into the cell separation chamber so as to allow force for causing cells to be put together to act into the cell separation chamber. In addition, an electrostatic force is allowed to act in the cell separation chamber so as to cause the cell to move by the charges of the cells. Competition between both the forces is used to separate the cells correspondingly to the freshness of the cells.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: June 12, 2001
    Assignee: Hitachi, Ltd.
    Inventors: Kenji Yasuda, Takeshi Sakamoto
  • Patent number: 6231826
    Abstract: Process and apparatus for refining silicon by treatment in a graphite vessel with irradiation with an electron beam while removing impurity elements by evaporation. A single graphite vessel is used, or plural graphite vessels are arranged in sequence. During treatment in successive graphite vessels, molten silicon is poured in succession from one vessel to another. Use of graphite vessels improves heat efficiency, prevents contamination and produces refined silicon containing very low contents of impurities.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: May 15, 2001
    Assignee: Kawasaki Steel Corporation
    Inventors: Kazuhiro Hanazawa, Masamichi Abe, Hiroyuki Baba, Naomichi Nakamura, Noriyoshi Yuge, Yasuhiko Sakaguchi, Yoshiei Kato, Fukuo Aratani