With Positive Pressure Or Vacuum Patents (Class 422/33)
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Patent number: 8669043Abstract: A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants. Goals include between about a one to twelve log reduction in bacterial contamination, between about a one to fifteen log reduction in enveloped virus contamination, up to about a five log reduction in non-enveloped virus contamination, between about a two to tenfold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.Type: GrantFiled: February 17, 2012Date of Patent: March 11, 2014Assignee: RTI Surgical, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8663555Abstract: Vacuum sterilization process with the application of vapour of a mixture of peracetic acid with hydrogen peroxide and residual gas plasma from atmospheric air, excited by pulsed electrical discharge; operational devices and methods used in the sterilization process, preferably a process of sterilization in vacuum, dry, and at low temperature (room temperature).Type: GrantFiled: August 7, 2009Date of Patent: March 4, 2014Assignee: CISA S.p.A.Inventor: Tadashi Shiosawa
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Patent number: 8658092Abstract: A chemical vapor sterilization process is enhanced by concentrating a germicide via exploitation of the difference between the vapor pressures of the germicide and its solvent. A diffusion restriction can be placed into the diffusion path to assist this process and the path then opened to provide rapid diffusion of the thus concentrated germicide. The path through the diffusion restriction can be closed to allow the pressure in a sterilization chamber to be lowered prior to receiving the concentrated germicide.Type: GrantFiled: February 15, 2013Date of Patent: February 25, 2014Assignee: Ethicon, Inc.Inventors: James P. Kohler, Szu-Min Lin, Richard Jed Kendall
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Patent number: 8658090Abstract: Methods and apparatus for liquid, gas, and gas plasma sterilization of items. The apparatus includes two chambers and a holder to connectorlessly secure a lumened instrument such that a first portion of the lumened instrument lies in the first chamber and a second portion of the instrument lies in the second chamber, a liquid medium contained within the two chambers, and pumping means for simultaneously increasing fluid pressure within the first chamber of said container while decreasing fluid pressure within the second chamber of the container in a reciprocating fashion. The pumping means displaces at least a total internal volume of the liquid medium through the lumen for a given highest volume of a lumened instrument during each stroke.Type: GrantFiled: October 8, 2008Date of Patent: February 25, 2014Assignee: Langford IC Systems, Inc.Inventor: Terrence R. Langford
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Patent number: 8658091Abstract: Treating absorbable sutures that have been sterilized using ethylene oxide with carbon dioxide at or near its supercritical pressure and temperature conditions to remove any residual ethylene oxide.Type: GrantFiled: September 15, 2011Date of Patent: February 25, 2014Assignee: Novasterilis, Inc.Inventors: David Burns, Anastasia J Nichols
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Publication number: 20140037495Abstract: In a low temperature hydrogen peroxide gas plasma sterilizer, the accurate control of concentration of the hydrogen peroxide sterilant is an important factor in determining reliability and sterilization efficacy of the sterilization process. The present application describes sterilizers, and sterilization methods, which use a novel injector-concentrator arrangement which allows accurate concentration of the sterilant performed concurrently with the sterilization process. This process enables the device to sterilize wide range of sensitive equipment within a shorter sterilization cycle.Type: ApplicationFiled: August 1, 2013Publication date: February 6, 2014Inventors: Fatih Ahiska, Yavuz Ahiska, Tolga Ahiska
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Patent number: 8642061Abstract: In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.Type: GrantFiled: June 16, 2008Date of Patent: February 4, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Lawrence A. Shimp, Guobao Wei, Keyvan Behnam
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Publication number: 20140017122Abstract: The present invention generally relates to water disinfection systems for use in dental operatory settings. In particular, a dental water disinfector is described, wherein the dental water disinfector is configured to purify water used during a dental procedure. In preferred embodiments of the present invention, the dental water disinfector is utilized to eliminate bacterial contaminants present in water supplies utilized by dental drills and irrigation equipment.Type: ApplicationFiled: July 12, 2012Publication date: January 16, 2014Applicants: DRINKABLE AIR, INC., UNION DENTAL HOLDINGS, INC.Inventor: George Green
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Patent number: 8617465Abstract: A dialysis disposable sterilization method including: fitting a cap to a connector such that a cap/connector interface can hold a pressure; applying a sterilizing gas through an inside of the connector such that the gas flows through (i) the inside of the connector, (ii) around to the outside of the connector, (iii) past a stabilization rib, and (iv) into contact with one side of the cap/connector interface; and applying the sterilizing gas at an outside of the cap such that the sterilizing gas flows around a bottom of the cap and contacts an opposing side of the cap/connector interface.Type: GrantFiled: September 15, 2009Date of Patent: December 31, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Patrick Jong Lee, Serhan Acikgoz, Yuanpang Samuel Ding
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Patent number: 8591808Abstract: A nebulant suitable for sterilization comprising finely divided liquid droplets suspended in a gas, said droplets including a solute, which is advantageously hydrogen peroxide and a solvent, for example water, wherein the droplets have a concentration of greater than 60 wt % of solute and an average diameter of less than 1.0 micron, preferably less than 0.8 microns.Type: GrantFiled: August 4, 2006Date of Patent: November 26, 2013Assignee: Saban Ventures Pty LimitedInventors: Vladimir Berentsveig, Gary Erickson, Ron Weinberger
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Patent number: 8568666Abstract: Methods and apparatus for liquid, gas, and gas plasma sterilization of items. The apparatus includes two chambers and a holder to connectorlessly secure a lumened instrument such that a first portion of the lumened instrument lies in the first chamber and a second portion of the instrument lies in the second chamber, a liquid medium contained within the two chambers, and pumping means for simultaneously increasing fluid pressure within the first chamber of said container while decreasing fluid pressure within the second chamber of the container in a reciprocating fashion. The pumping means displaces at least a total internal volume of the liquid medium through the lumen for a given highest volume of a lumened instrument during a stroke.Type: GrantFiled: September 20, 2012Date of Patent: October 29, 2013Assignee: Langford IC Systems, Inc.Inventor: Terrence R. Langford
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Patent number: 8557179Abstract: The invention provides a device comprising a sealed interior portion with at least one opening covered by a sterilization barrier formed from a non-porous material allowing a sterilization gas to penetrate but prevents germs from penetrating. The size and configuration of the at least one sterilization barrier formed from a non-porous material are adapted to allow at least 50% of the sterilization gas, that would pass between a sterilization gas-containing exterior and the sealed interior portion when a pressure difference is created there between, to pass through the non-porous material.Type: GrantFiled: October 31, 2008Date of Patent: October 15, 2013Assignee: Novo Nordisk A/SInventors: Bjørn Gullak Larsen, Brian Jensen, Ulla Holm Christensen
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Publication number: 20130243649Abstract: A method of controlling unwanted condensation of hydrogen peroxide in a sterilization chamber at a preselected temperature is disclosed. The method includes the steps of maintaining the sterilization chamber at a vacuum pressure below the pressure at which hydrogen peroxide will boil at the preselected temperature, evaporating successive pulses of hydrogen peroxide, and injecting the evaporated hydrogen peroxide into the chamber, whereby the volume of each pulse of hydrogen peroxide is less than 75 ?L, preferably less than 35 ?L, most preferably less than 20 ?L. Sterilization results are improved by controlling unwanted condensation of hydrogen peroxide.Type: ApplicationFiled: February 27, 2013Publication date: September 19, 2013Applicant: TSO3 INC.Inventors: Sylvie DUFRESNE, Jean-Martin VALLIERES, Bruno TREMBLAY
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Publication number: 20130236357Abstract: A method of metering of hydrogen peroxide gas into an evacuated sterilization chamber is disclosed. The method includes the steps of continuously monitoring a pressure in the sterilization chamber; connecting a passage of known volume to the evacuated chamber for evacuating the passage; sealing the passage; connecting the evacuated passage to a supply of hydrogen peroxide solution for a time sufficient to draw the hydrogen peroxide solution into and fill the passage; sealing the passage; and repeating those steps until a preselected pressure increase in the sterilization chamber is detected. The pressure increase is preferably 19 Torr. The known volume of the metering passage is preferably between 75 ?L and 15 ?L to control unwanted condensation of hydrogen peroxide in the sterilization chamber. Expensive peroxide concentration measurement systems are replaced with an economical low cost pressure sensor for control of the hydrogen peroxide concentration.Type: ApplicationFiled: February 27, 2013Publication date: September 12, 2013Applicant: TSO3 INC.Inventors: Bruno TREMBLAY, Jean-Martin VALLIERES
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Publication number: 20130236359Abstract: A method of sterilizing a vacuum system, comprising: creating a vacuum in a vacuum chamber such that a pressure differential is formed between the vacuum chamber and a liquid sterilant supply, and wherein the liquid sterilant supply has a higher pressure than the vacuum chamber; vaporizing liquid sterilant; and sterilizing the vacuum chamber with the vaporized sterilant.Type: ApplicationFiled: April 29, 2013Publication date: September 12, 2013Applicant: SP INDUSTRIES, INC.Inventor: Christopher Wayne Burger
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Publication number: 20130236354Abstract: A valve apparatus and methods associated thereof are provided. The valve apparatus includes a valve housing structure. A first valve portion is connected to the valve housing structure, wherein the first valve portion has a sealing edge. A second valve portion is positioned at least partially within the valve housing structure. A constrictable membrane has a pressurizable interior compartment, wherein the constrictable membrane supported by the second valve portion and positioned proximate to the first valve portion, wherein at least a portion of the constrictable membrane is movable to engageable with the sealing edge of the first valve portion.Type: ApplicationFiled: March 9, 2012Publication date: September 12, 2013Applicant: SYMMETRY MEDICAL MANUFACTURING, INC.Inventors: Jon B. Taylor, James J. Kennedy, III, Paul LaRue, George P. Hannafin
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Publication number: 20130236358Abstract: Methods and systems for virus inactivation in the production or processing of biological or other sensitive substances are provided. The disclosed methods and systems for virus inactivation involve the key steps of dissolving carbon dioxide into biological or other sensitive substances; and treating the substance with the dissolved carbon dioxide at conditions which are less than critical pressure and temperature for a prescribed treatment time to inactivate at least 80% of the target virus or viruses contained within the biological or other sensitive substances. The disclosed carbon dioxide treatments for virus inactivation may optionally include concurrently or sequentially subjecting the substances with an acid treatment to lower the pH of the substance and inactivate viruses contained within the biological or other sensitive substance.Type: ApplicationFiled: March 12, 2013Publication date: September 12, 2013Inventors: Peter W. Latham, Nigel Grinter, Robert Sever
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Publication number: 20130236356Abstract: A method of metering a preselected volume of hydrogen peroxide into a vessel under vacuum is disclosed. The method comprises the steps of connecting a passage of known volume to the vessel under vacuum to evacuate the passage; sealing the passage; connecting the passage to a supply of hydrogen peroxide solution for a time sufficient to draw the hydrogen peroxide solution into the evacuated passage and fill the passage with the hydrogen peroxide solution; sealing the passage; and repeating steps a) to d) until a cumulative volume of fills of the passage is equal to the preselected volume. The volume of the passage is preferably 15 ?L to 75 ?L. Sterilization is controlled in an economic manner by obviating the need for a means to measure the hydrogen peroxide concentration in the chamber.Type: ApplicationFiled: February 27, 2013Publication date: September 12, 2013Applicant: TSO3 INC.Inventors: Bruno TREMBLAY, Jean-Martin VALLIERES
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Publication number: 20130236355Abstract: Disclosed is a method of sterilizing an article by sequentially exposing the article under vacuum first to a gaseous conditioning agent for forming radicals and then to a sterilant. The preferred conditioning agent is hydrogen peroxide and the preferred sterilant is ozone. The chamber is initially evacuated to a first vacuum pressure and then sealed for the remainder of the sterilization process and during all sterilant injection cycles, without removal of any component of the sterilization atmosphere, which means without any measures to reduce the water vapor content. Keeping the chamber sealed and maintaining the conditioning agent and the radicals generated thereby in the chamber for the sterilization with sterilant results in a synergistic increase in the sterilization efficiency and allows for the use of much lower sterilant amounts and sterilization cycle times than would be expected from using the conditioning agent and the sterilant in combination.Type: ApplicationFiled: February 27, 2013Publication date: September 12, 2013Applicant: TSO3 INC.Inventors: Sylvie DUFRESNE, Cynthia MARTEL, Helene LEBLOND, Nancy DASSIE, Karine MARTEL
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Patent number: 8530808Abstract: Apparatus are provided which include a specimen vessel holding at least one biological sample. A histological agent is in the specimen vessel so as to come into contact with the tissue sample. A microwave susceptor is provided in, near, or integral to the specimen vessel.Type: GrantFiled: September 8, 2006Date of Patent: September 10, 2013Assignee: Energy Beam Sciences, Inc.Inventor: Phillip Michael McArdle
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Patent number: 8529832Abstract: A method for sterilization according to the present invention comprises: a first sterilization step of providing a sterilization subject in a sealed sterilization chamber and sterilizing the sterilization subject by providing ozone inside the sterilization chamber; a first decomposition step of decomposing the ozone inside the sterilization chamber; a first vacuumization step discharging the gas inside the sterilization chamber and reducing the pressure inside the sterilization chamber; a second sterilization step of providing hydrogen peroxide into the vacuumized sterilization chamber to sterilize the sterilization subject; a third sterilization step of providing ozone into the sterilization chamber; a second decomposition step of decomposing the hydrogen peroxide and ozone inside the sterilization chamber; and a second vacuumization step of discharging the gas inside the sterilization chamber and reducing the pressure inside the sterilization chamber.Type: GrantFiled: June 27, 2008Date of Patent: September 10, 2013Assignee: Renosem Co., Ltd.Inventor: Kwang-Sik Lee
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Publication number: 20130202485Abstract: Methods for disinfecting or sterilizing an article are provided. One method includes vaporizing a solution comprising a biocide in a solvent having a first biocide:solvent ratio, directing a flow of the vapour to a first side of a membrane; directing an alternate flow of gas to a second side of the membrane to increase the first biocide:solvent ratio on the first side to a second biocide:solvent ratio greater than the first biocide:solvent ratio thereby producing a concentrated vapour on the first side of the membrane, and contacting the article with the concentrated vapour for a time sufficient to disinfect or sterilize it.Type: ApplicationFiled: January 29, 2013Publication date: August 8, 2013Applicant: SABAN VENTURES PTY LIMITEDInventor: Saban Ventures Pty Limited
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Patent number: 8486332Abstract: A method and apparatus for the sanitization, detoxification, disinfection, high level disinfection, or sterilization of both the interior and exterior surfaces of an object, including those with lumens and/or channels of various sizes, within a closed space, or closed system of space, in addition to their surrounding atmosphere, and relates particularly, though not exclusively, to the generation of an aerosol including an anti-pathogen/toxin/fungal/sporicidal agent(s) or substance(s) (applied agent), or chemical neutralizing agent(s) or substance(s), by way of one or more ultrasonic nebulizer(s). However the applied agent used in the present invention may also be in the form of any gas, vapor, plasma, aerosol, or other form. The apparatus and method also includes an option to incorporate and utilize a means to wash the object. The present invention includes the application of a positive or negative air/gas pressure to the internal space, lumens, ducts, or channels, of an object.Type: GrantFiled: November 21, 2011Date of Patent: July 16, 2013Inventors: Jonathan J. Ricciardi, Carl L. Ricciardi, Howard J. Swidler
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Patent number: 8465652Abstract: The invention relates to a technique of disinfecting household and industrial waste water used as the basis of organo-mineral fertilizers. The present method of disinfection is carried out by means of quick vacuum-pulse actions on sewage sludge using a receiver and quick response valves, with a pulse duration of less than 1.0 seconds at a pressure of not more than 20 mmHg to achieve the required degree of disinfection. Technical result of the use of the invention is to accelerate and simplify the process of disinfection method.Type: GrantFiled: December 16, 2010Date of Patent: June 18, 2013Assignee: Twin Trading CompanyInventors: Yakov Kuzmich Abramov, Vladimir Mihailovich Veselov, Viktor Mihailovich Zalevsky, Vitaly Grigorevich Tamurka, Nikolay Dmitrievich Argunov, Ljubov′ Viktorovna Motovilova, Nikolay Vladimirovich Dvoryaninov, Lidija Petrovna Bogdanova
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Publication number: 20130105025Abstract: The present invention relates to a method for sterilizing at least one object, wherein the object is exposed to a sterilization agent, wherein at least one first support pressure and at least one second support pressure are applied and wherein a sterilization of a first region of the object takes place by the sterilization agent at the first support pressure and a sterilization of a second region of the object takes place at the second support pressure. The present invention furthermore relates to a sterilizing apparatus and to a use herefor.Type: ApplicationFiled: July 5, 2011Publication date: May 2, 2013Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Thorsten Fehr, Claus Haupert, Franz Kugelmann, Nicole Simon
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Publication number: 20130101462Abstract: A hollow body sterilizing or disinfection method using a sterilizing agent, such as periacetic acid or hydrogen peroxide, introduced into a body at ambient pressure from a vaporizer includes supplying the sterilizing agent in the vaporizer as dry sterilizing agent vapor, the dry sterilizing agent vapor comprising vapor with a sterilizing agent quantity or vapor density that is at most equal to and preferably less than saturated vapor density such that upon introduction of the sterilizing agent vapor into the hollow body and upon subsequent expansion of the sterilizing agent vapor from a pressure in the vaporizer to ambient pressure, condensate formation occurs substantially only on a surface of the hollow body.Type: ApplicationFiled: May 24, 2011Publication date: April 25, 2013Applicant: KHS GmbHInventor: Gernot Keil
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Patent number: 8425837Abstract: A system for gas sterilization includes a sterilization chamber, a source of sterilant gas, and a sterilant gas remediation mechanism. Embodiments relate to systems and methods for delivering humidified air to a sterilization chamber, systems and methods for removing gaseous NO2 from an exhaust gas stream of a sterilization chamber, systems and methods for removing and replacing a source of sterilant gas, an exhaust gas scrubber and/or supplies for a humidification system. Some embodiments relate to hardware and software for user interface in a sterilizing device and hardware and software for control of a sterilization cycle. Some embodiments relate to chamber, chassis and door configurations of a sterilizer.Type: GrantFiled: February 22, 2010Date of Patent: April 23, 2013Assignee: Noxilizer, Inc.Inventors: Phil Carbone, Karen Benedek, Michael O. Ruffo, Wade Luongo
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Publication number: 20130089462Abstract: There is provided a sterilization apparatus for sterilizing an object. The sterilization apparatus includes a concentration chamber configured to concentrate sterilizer, a vaporizing chamber configured to vaporize the sterilizer, a measuring pipe into which the sterilizer is introduced from the concentration chamber before being introduced into the vaporizing chamber, a vacuuming device configured to vacuum the sterilization chamber, and a first valve configured to be opened and closed to control communication between the sterilization chamber and the measuring pipe, wherein after the sterilizer is introduced from the concentration chamber into the measuring pipe, gas contained in the measuring pipe is removed from the measuring pipe by opening the first valve.Type: ApplicationFiled: October 4, 2012Publication date: April 11, 2013Applicants: CANON MARKETING JAPAN KABUSHIKI KAISHA, KABUSHIKI KAISHA ELQUEST, ELK CORPORATIONInventors: CANON MARKETING JAPAN KABUSHIKI KAISH, ELK CORPORATION, KABUSHIKI KAISHA ELQUEST
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Publication number: 20130089461Abstract: A sterilizing apparatus provides a structure for feeding a sterilizer left in a vaporizing chamber configured to gasify the sterilizer, into a sterilizing chamber, to stimulate a sterilizing action while reducing waste of the sterilizer. The sterilizing apparatus includes a first atmosphere opening valve configured to perform an opening/closing operation to control communication between the atmosphere and the vaporizing chamber for vaporizing the sterilizer before the sterilizer is injected into the sterilizing chamber, and after a sterilizing gas vaporized in the vaporizing chamber is injected into the sterilizing chamber by vacuuming the vaporizing chamber with a vacuum pump, the vaporizing chamber and the atmosphere communicate with each other when the first atmosphere opening valve is opened while the vaporizing chamber and the sterilizing chamber communicate with each other.Type: ApplicationFiled: October 4, 2012Publication date: April 11, 2013Applicants: CANON MARKETING JAPAN KABUSHIKI KAISHA, KABUSHIKI KAISHA ELQUEST, ELK CORPORATIONInventors: CANON MARKETING JAPAN KABUSHIKI KAISH, ELK CORPORATION, KABUSHIKI KAISHA ELQUEST
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Patent number: 8372339Abstract: The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.Type: GrantFiled: March 1, 2007Date of Patent: February 12, 2013Assignee: Getinge Sterilization ABInventors: Joakim Larsson, Bjarne Pedersen, Mats-Åke Åhlund, Stefan Nilsson
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Patent number: 8354057Abstract: A method of sterilizing a closed environment is provided in which a disinfection apparatus is placed into the closed environment; it then generates ozone to a predetermined ozone concentration, following which the humidity of the closed environment is rapidly increased. A catalytic converter then reduces the ozone concentration to safe levels. When the ozone concentration is reduced to a predetermined safe level, the disinfection apparatus signals.Type: GrantFiled: June 17, 2008Date of Patent: January 15, 2013Inventors: Doug Heselton, Nigel Boast, Jim Hudson, Gordon Esplin
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Patent number: 8334521Abstract: The invention concerns a medical instrument disinfecting system (1) comprising a disinfecting chamber (4) adapted to implement a cycle for disinfecting the instruments. The invention is characterized in that each instrument (1) comprises identification data (5) and in that the chamber (4) is associated with means (6) for acquiring the identification data of the or each instrument (1) when it is introduced into or withdrawn from the chamber (4) at the start and at the end of a disinfecting cycle, with means (7, 8) for acquiring characterization data of the disinfecting cycle and with means (9, 10, 11, 12, 13) for associating the identification data of the or each instrument and the characterization data of the disinfecting cycle to generate traceability data of the disinfection of the or each instrument.Type: GrantFiled: December 5, 2005Date of Patent: December 18, 2012Assignee: GermitecInventor: Clement Deshays
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Patent number: 8327606Abstract: A method and apparatus for sterilization in which items to be sterilized are placed in an impervious sealable package and the sterilization process is carried out within the package. The apparatus (10) includes a cabinet (18) in which a package (P) preferably with a carrier (11) located within, can be positioned. A snorkel (17) is inserted into the package (P) and via connector (23) vacuum, pressure and sterilant can be applied to the interior of the package (P). A sealing arrangement (14b, 22b) can seal the package closed after the sterilization process has been completed.Type: GrantFiled: October 20, 2006Date of Patent: December 11, 2012Assignee: Mercer Technologies LimitedInventors: Terry Dean Kemp, Christo Andre De Klerk
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Patent number: 8329098Abstract: A method which enhances a disinfection process by obtaining an additive effect from energy and byproducts of the decomposition process. Also disclosed are contact lens disinfecting systems, wherein the systems are configured to create the desirable elevated pressure, oxygen saturation and sustained peroxide concentration conditions within a contact lens holding and reaction chamber, in order to enhance disinfection by additive effect. The systems are configured to provide that an elevated pressure is maintained in the reaction chamber before venting occurs.Type: GrantFiled: October 22, 2009Date of Patent: December 11, 2012Assignee: Atrion Medical Products, Inc.Inventor: Rowland W. Kanner
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Publication number: 20120301356Abstract: A system for decontaminating a medical device includes a decontamination chamber configured to retain the medical device and a chemical dispersion assembly configured to deliver a decontaminating fluid to the decontamination chamber. A pressure control assembly is connected to the decontamination chamber and configured to control the pressure in the decontamination chamber. The system also includes a system controller configured to control the decontamination chamber, chemical dispersion assembly, and pressure control assembly. A pressure in the decontamination chamber is reduced to within a sub-atmospheric pressure range in a first evacuation step and add a decontaminating fluid into the decontamination chamber at a first rate while increasing the pressure in the decontamination chamber. Adding the decontaminating fluid increases a relative humidity in the decontamination chamber to a level that improves the efficacy of the decontaminating fluid.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Applicant: MINNTECH CORPORATIONInventors: Jonathan K. Olson, Mason Schwartz
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Publication number: 20120302499Abstract: Methods for sterilizing and decellularizing extracellular matrix materials are disclosed. Extracellular matrix compositions produced using the disclosed methods are also disclosed.Type: ApplicationFiled: May 24, 2012Publication date: November 29, 2012Inventor: ROBERT G. MATHENY
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Patent number: 8316905Abstract: An isostatic press is disclosed in which tunnel-like passages are formed between the envelope surface of a force absorbing body and a prestressing device. A method and a press are further disclosed, wherein a cylindrical element is prestressed simultaneously with obtaining a tunnel-like passage on the cylindrical element.Type: GrantFiled: February 18, 2004Date of Patent: November 27, 2012Assignee: Avure Technologies ABInventors: Stefan Sehlstedt, Lennart Svensson
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Publication number: 20120275954Abstract: An apparatus and method for achieving low temperature vapor sterilization of objects which may involve objects having a lumen. Following evacuation of the sterilization chamber and the introduction of a vaporous or gaseous sterilant, the volume of the chamber is changed by actuation of a movable boundary in the chamber to increase and decrease the pressure in the chamber thus driving the sterilant into and out of such lumens.Type: ApplicationFiled: March 16, 2012Publication date: November 1, 2012Applicant: STERILUCENT, INC.Inventor: Steven J. Olson
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Patent number: 8298481Abstract: A method for sterilizing a plastic bottle in an aseptic filling system according to which at least an inner surface or an outer surface of a bottle is sterilized by injecting a heated sterilizing fluid at 65° C.-90° C. while maintaining internal pressure of the bottle at 1 kPa-20 kPa.Type: GrantFiled: October 18, 2011Date of Patent: October 30, 2012Assignee: Toyo Seikan Kaisha, Ltd.Inventors: Takeshi Iwashita, Yonosuke Takahara, Kenichi Kominami, Ken Isogawa
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Patent number: 8268257Abstract: Described is a process and an arrangement for the treatment of objects, in particular for sterilization, comprising at least one chamber for the joint take-up of at least two objects to be treated. A closing element is arranged to the opening of the chamber, which closing element is arranged in a moveable way in the arrangement for the purposes of opening and closing the opening. The chamber can be closed by means of the closing element in a vacuum-tight way, whereby no relative movement takes place between the closing element and the chamber in the closed state. It is provided that the minimum of two objects to be treated are inserted one after the other, and that the closing of the opening by means of the minimum one closing element takes place essentially on a continuous basis.Type: GrantFiled: May 10, 2007Date of Patent: September 18, 2012Assignee: PTM Packaging Tools Machinery Pte. Ltd.Inventor: Robert Frost
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Patent number: 8268239Abstract: A method for sterilizing contact lenses included in a moist environment in a closed package, wherein the package is heated, wherein the heating is carried out by introducing the package into a space which is at superatmospheric pressure or which is adjusted to superatmospheric pressure and which is heated with dry hot air. Further, the invention relates to an apparatus for carrying out such a method.Type: GrantFiled: May 4, 2007Date of Patent: September 18, 2012Assignee: OTB Group B.V.Inventors: Franciscus Cornelius Dings, Michael Adrianus T. Hompus, Michiel Paulus A. M. Prinz, Wilhelmus Godefridus J. P. Swinkels
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Patent number: 8268241Abstract: A process wherein outgassing rates of volatile organic compounds (VOCs) in an object, particularly habitable vehicles, are accelerated by placing the subject object in a vacuum chamber and placing heat sources either inside the object being treated, outside the object, or both. The process includes measuring and monitoring the temperature of selected surfaces inside the object being treated. The heat sources are adjusted to maintain a temperature which is safe for the materials and which will promote maximum outgassing rates. During the treatment process, while a vacuum and heat are being applied to the subject object, the gasses in the chamber are monitored for both their composition and quantity. When the outgassing rates of the VOCs reach acceptable levels, the process cycle is terminated. The vacuum in the chamber is broken to restore atmospheric pressure, and the object being treated is removed from the chamber.Type: GrantFiled: October 14, 2008Date of Patent: September 18, 2012Inventor: Henry W. Cooper
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Patent number: 8246905Abstract: A method for disinfecting a microtome cryostat (1) comprises a defrosting phase (11), provision (13) of a vaporous disinfection agent (2) which acts upon the closed cryostat chamber (3) and a period of time (14) during which said disinfection agent (2) acts, and having an associated device for carrying out the method. According to the invention, fast and effective disinfection and rapid restarting of a microtome cryostat (1) is possible with secure drying, the temperature difference (?T1, ?T2) being produced after the period of time (14) in the cryostat chamber (3) whereupon the precipitated disinfection agent (2) is removed (18) to a cold area.Type: GrantFiled: April 2, 2008Date of Patent: August 21, 2012Assignee: MICROM International GmbHInventor: Dieter Teppke
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Patent number: 8221681Abstract: Embodiments of the invention generally provide an apparatus and method for decontaminating tubing. The invention is particularly suitable for decontaminating tubing in a test system used for certifying a filter in a containment system. In one embodiment, a test system for a containment system is provide that includes a sample system including equipment adapted for testing a filter disposed in a containment system utilizing samples obtained from a downstream sample port and a upstream sample port of the containment system, and a device for reversing a flow within the sample system. In another aspect of the invention, a method for decontaminating tubing is provided. In another embodiment, the method includes flowing a sterilization agent through tubing in a first direction and flowing the sterilization agent through tubing in a second direction.Type: GrantFiled: August 21, 2009Date of Patent: July 17, 2012Assignee: Camfil Farr, Inc.Inventor: Steven T. Devine
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Publication number: 20120171077Abstract: Systems and methods for decontaminating a facility, for example, in response to a biological attack. An exclusion zone, a support zone, and a contamination reduction zone may be established. The exclusion zone may have a suspected contaminant in one or more of its areas. The contamination reduction zone may be between the exclusion zone and the support zone. The exclusion zone may have an agent introduced into a pressurized environment within the exclusion zone to substantially eliminate the contaminant. A sample may be taken to determine the presence of the contaminant.Type: ApplicationFiled: October 19, 2007Publication date: July 5, 2012Inventors: John H. Bridges, III, Dennis M. Baca
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Publication number: 20120114524Abstract: Methods and systems for the terminal sterilization and surface decontamination of prefilled containers containing sensitive drug products, such as biotech drug products that are otherwise temperature or radiation sensitive, and thus not suitable for terminal sterilization by classical methods involving steam or gamma rays. The methods and systems are especially suited for prefilled containers in secondary packaging. Methods include terminal sterilization by exposing prefilled containers in secondary packaging to tunable-beta radiation and further include terminal sterilization by exposing prefilled containers to controllable vaporized-hydrogen peroxide, including application of measures to reduce or prevent diffusion of vaporized-hydrogen peroxide into prefilled containers.Type: ApplicationFiled: July 13, 2010Publication date: May 10, 2012Inventor: Juergen Sigg
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Publication number: 20120095178Abstract: The invention relates to a new process for treatment of residual nucleic acids present on the surface of laboratory consumables. This process combines two treatment phases: i) Treating with ethylene oxide in gaseous phase; then ii) Treating said surface with hydrogen peroxide in liquid phase or in gaseous phase; The effect of this treatment is to avoid the amplification of said residual nucleic acids, in particular during PCR or TMA reactions.Type: ApplicationFiled: October 18, 2011Publication date: April 19, 2012Applicant: Millipore CorporationInventors: Marie Pressel, Didier Metz
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Publication number: 20120076689Abstract: A method for sterilizing a plastic bottle in an aseptic filling system according to which at least an inner surface or an outer surface of a bottle is sterilized by injecting a heated sterilizing fluid at 65° C.-90° C. while maintaining internal pressure of the bottle at 1 kPa-20 kPa.Type: ApplicationFiled: October 18, 2011Publication date: March 29, 2012Applicant: TOYO SEIKAN KAISHA, LTD.Inventors: Takeshi Iwashita, Yonosuke Takahara, Kenichi Kominami, Ken Isogawa
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Patent number: 8142991Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: February 19, 2009Date of Patent: March 27, 2012Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8142716Abstract: An improved method of purifying a fluid having fluid-borne contaminants I including the steps of: providing a pump (21) having an inlet (22) and an outlet (23); connecting the pump inlet to a source (24) of contaminated fluid; operating the pump at. a pressure ratio of at least 2.0 so as to sufficiently elevate the temperature of the fluid and contaminants passing through the pump, or, alternatively, operating the pump so that the outlet temperature of the fluid and contaminants passing therethrough is at least about 200° C.; and controlling the time during which the temperature of the fluid and contaminants are elevated; thereby to alter or convert substantially all of the contaminants passing through the pump.Type: GrantFiled: October 12, 2010Date of Patent: March 27, 2012Assignee: Research Foundation of State University of New YorkInventors: James F. Garvey, John A. Lordi, Joseph Mollendorf, James D. Felske