Abstract: A container and method for cleaning, rinsing, disinfecting, or sterilizing a device disposes an instrument in a container below partition having an aperture for passing fluid. The container is filled to a level above the partition to ensure that the device is submerged in the fluid.

Abstract: A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized.

Abstract: A device and method for cleaning and sterilizing tubular structures particularly, long, narrow tubular structures such as lumens of a medical device such as an endoscope by reversing the flow of fluid in interconnected tubular structures. The device comprises a first and second valve in fluid communication with a first and second tubular structure. The valves selectively switch between a first and second position causing a first and second flow path within the tubular structures, at least a part of the second flow path opposite the first flow path.

Abstract: This invention is related to methods for inactivating micro-organisms using high pressure processing. A method is described for inactivating micro-organisms in a product using high pressure processing including the steps of packing said product in a flexible container, heating said product to a pre-pressurized temperature, subjecting said product to a pressure at a pressurized temperature for a time period; and reducing the pressure after said time period. The method of the present invention could further comprise an additional step of subjecting said product to a predetermined amount of oxygen for a time interval. The methods of the present invention may be applied preferably to food, cosmetic or pharmaceutical products.

Abstract: The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilizer and sterilizing articles therewith. This concentrating process is monitored by determining the concentrations of water and peroxide in the chamber.

Abstract: A device for the treatment of objects using an effective amount of ozone, the device comprising at least two sealed treatment chambers into which a person inserts at least one object to be treated, each treatment chamber being hermetically sealed by a sealing means to provide a complete seal, a distribution means for delivering the ozone-oxygen to each of the treatment chambers, a control system being designed to produce a static mode operation wherein there is no ozone flow into or out of the treatment chamber except during testing periods when a negative pressure is produced in each treatment chamber. The inventions also pertains to an improved device for treating wound, ulcers, burns, skin and immune system disorders, thrombotic diseases, and disorders of blood platelets, diabetes or peripheral vascular diseases.

Abstract: A method of sterilizing musical instruments is provided. More particularly, a method of sterilizing musical wind instruments and accessories related thereto is provided for sterilizing, or at least sanitizing, musical wind instruments and accessories without damaging or degrading components of such instruments and accessories constructed of cloth, wood, plastic, rubber or fibrous materials. The method of the invention uses a gas diffusion process and a gas sterilant, such as ethylene oxide. A musical wind instrument and/or an accessory is placed in a gas diffusion bag and a sterilizing atmosphere is created within the gas diffusion bag by releasing ethylene oxide into the gas diffusion bag at a sufficient concentration to act as a sterilant. Ethylene oxide is heated to an appropriate temperature and maintained at such temperature for a sufficient time to achieve sterilization, or at least sanitization, of the musical wind instrument and/or accessory contained therein.

Abstract: The disclosure relates to a method of disinfecting medical theatre care equipment comprising the steps of causing ozonated water to flow over the surfaces of the equipment at a predetermined concentration and flow rate for a predetermined time and monitoring the concentration of ozone in the water leaving the equipment. The flow is terminated when the concentration of ozone leaving the equipment is substantially the same as that being delivered to the equipment.

Abstract: This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.

Abstract: Growth of toxic molds in residential and commercial buildings is prevented or eradicated by installing a system including liquid spray nozzle units within interior walls spaces likely to accumulate moisture. Spray nozzles are mounted in spaces between column or stud members of interior walls, plumbing chases, or similar locations and may be manifolded and connected to a fitting projecting through a wall in an inconspicuous location for connection to a portable pump unit for spraying surfaces of structural elements adjacent the spray nozzles. Methods for treating building interiors include applying a spray of anti-microbial treatment fluid to interior facing surfaces of exterior walls, plumbing chases, interior bathroom and kitchen wall column members and floor plates, floors, such as concrete slabs or wood flooring surfaces, roof penetrations and subfloors for utility appliances.

Abstract: A method is provided for rapidly determining whether a load of equipment to be sterilized in a sterilization chamber absorbs, adsorbs, condenses, or decomposes significant amounts of germicide vapor or gas, such as hydrogen peroxide. The initial slope of the curve of a plot of ln(c/c0) versus time is determined, where c is the concentration of hydrogen peroxide and c0 is the maximum concentration of hydrogen peroxide. The initial slope is determined in the first 100 seconds after the maximum in the concentration of hydrogen peroxide. If the initial slope is approximately 0.016 sec−1 or less, the load is acceptable. If the initial slope is significantly steeper than 0.016 sec−1, the load absorbs, adsorbs, condenses, or decomposes significant amounts of hydrogen peroxide. If the slope of the curve is steep, the system can abort the sterilization run before significant amounts of hydrogen peroxide have been absorbed, adsorbed, or condensed.

Abstract: A device and method provide an aerosol germicide to a device having a lumen within a container. The container is divided into at least two compartments by an interface across which extends the lumen device, with one end of the lumen in one compartment and another end of the lumen in another compartment. A pressure differential can be used to flow the germicide through the lumen.

Abstract: This invention relates to a method and apparatus for using ozone to disinfect and decontaminate infectious microbial agents including mold in a building or container. This invention contemplates treating biological and viral agents with ozone containing gases.

Abstract: A sterilization system employs an attachable/detachable container to which is connected a source of sterilant for sterilizing items within the container. When disconnected from the source of sterilant the container is sealed from microbial ingress.

Abstract: A method and an apparatus are disclosed to effectively flow the fluid through the lumen device during the cleaning, disinfecting or sterilizing process, preferably with the use of two interfaces and two sources of fluid. By flowing the fluid into two adjacent compartments, the loss of the fluid due to the gap can be reduced or eliminated.

Abstract: The continuous process for hyperactivation of fluids for sterilization uses a sterilizing fluid which is mixed with a gas that is inert with respect to the fluid. A sterilizing mixture is obtained which is subsequently evaporated by means of introduction into an evaporation tube in a condition of annular motion, where a liquid phase of the mixture flows against the heated walls of the evaporator at a slower speed than the gaseous phase thereof, which flows in the central zone of the evaporator, internally of the liquid phase. A gaseous vapour/inert gas mixture is thus obtained, which is subjected to a waiting period during which the mixture flows through a transit device which transfers it to a sterilization chamber, a temperature of which is lower than a dewpoint temperature of the gaseous mixture, where a product is sterilized.

Abstract: An enclosure assembly (10, 10, 10) includes a framework (12) formed from structural members and a flexible transparent enclosure (14) which provides an enclosed space for isolation and or treatment of patients, equipment, and the like. A treatment material, such as hydrogen peroxide or other gaseous or vapor sterilant, may be fed to the enclosure to microbially decontaminate or otherwise treat the equipment. The enclosure is quickly assembled and disassembled after use, making it suitable for treatment of large pieces of equipment which are not readily moved or which are too large to be accommodated conventional sterilization equipment.

Abstract: A method of impregnating a polymeric medical device with an antimicrobial agent is disclosed. The method involves forming a solution by dissolving triclosan in a compressed fluid and contacting the polymeric medical device with the solution. After the solution has been infused into the polymeric medical device, the solution and the medical device are separated.

Abstract: An improved method of counteracting or neutralizing airborne malodour comprising directing at the source of the malodour liquid droplets from a spray device containing a malodour counteracting composition, the improved method comprising imparting a unipolar charge to the said liquid droplets by double layer charging during the spraying of the liquid droplets by the spray device, the unipolar charge being at a level such that the said droplets have a charge to mass ratio of at least ±1×10−4C/kg.

Abstract: Various forms of apparatus and methods for pretreating and sterilizing a lumen with a peroxide solution prior to sterilization of the interior of the lumen by exposing the lumen to reduced pressure and, optionally, plasma in a sterilization chamber. The pretreatment is preferably done before placing the lumen in the sterilization chamber. The method also includes exposure of the exterior of the lumen to peroxide vapor to sterilize the exterior of the lumen. Pretreatment of the interior of the lumen with liquid peroxide greatly improves the efficiency of sterilization of the interior. Exposure of the lumen to plasma reduces the time required for sterilization.

Abstract: The invention relates to a device for carrying out the process, which enables the disinfection of flat and enclosing surfaces using steam. In order to achieve this, a disinfection head 1, which exhibits a nozzle assembly 3 and a suction bell 6, is connected to a holder 2 such that it can move. The holder has an inlet hose 13 to enable the steam to be introduced into the disinfection head and an outlet suction hose 7. The inlet hose is connected to an initial evaporator cell 9 and the outlet suction hose is connected to a collection container 8. The initial evaporator cell, the collection is container, the suction pumps and the necessary valves and heating elements are joined together in a mobile unit 23.

Abstract: The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide from a vaporizer, which is connected to the sterilization chamber through the same port as the pump, and sterilizing articles therewith. The sterilant is concentrated by removing more water from the vaporizer than peroxide.

Abstract: The invention concerns a method for sterilising at least a sensitive active principle, characterised in that said at least active principle is treated at pressure levels ranging between 3000 and 6000 bars and at temperatures ranging between −30° C. and +25° C. The method consists in treating directly the active principle in the pulverulent medium wherein it is contained.

Abstract: A chamber (10) is supplied with a pressurized cleaning agent of carbon dioxide and cosolvents from a first source (12) and an antimicrobial fluid, such as ethylene oxide or hydrogen peroxide from a second source (16). Chamber conditions are maintained in the sub-critical range for the carbon dioxide. The cleaning agent and antimicrobial fluid are recirculated through a separator (32) and a condenser (38) to filter contaminants from the mixture before returning the carbon dioxide, and optionally the antimicrobial fluid and other additives, to the chamber. Medical instruments or other articles within the chamber are cleaned by the cleaning agent and sterilized by the antimicrobial fluid in a single cycle, rendering them ready for reuse in a short period of time. The instruments may be cleaned and stored in hermetically sealable containers (82). The cleaning agent is rapidly evaporated from surfaces of the articles at the end of the cycle by reducing the pressure in the chamber.

Abstract: Biomedical devices that are to come into contact with living tissue, such as prosthetic and other implants for the human body and the containers used to store and transport them, are together cleaned of non-living, but biologically active organic materials, including endotoxins such as lipopolysaccharides, and assembled into a hermetically sealed package without recontamination. This is achieved by cleaning both the device and package components together in an apparatus, which includes a hermetically sealed chamber, in which they are contacted with atomic oxygen which biocleans them, by oxidizing the biologically active organic materials. The apparatus also includes means for manipulating the device and container and hermetically sealing the cleaned device into the cleaned container to form the package. A calibrated witness coupon visually indicates whether or not the device and container have received enough exposure to the atomic oxygen to have removed the organic materials from their surfaces.

Abstract: A method of washing, microbially decontaminating, and rinsing of a lumened device (B), such as an endoscope includes positioning the device in a chamber (12) of an automated processor (A). Spray nozzles (102, 104, 106, 108, 110) within the chamber sequentially spray washing, microbial decontaminant, and rinse fluids over the device. Fluid connection ports (150, 152, 154) connect with internal passages (187) of the device for delivering the fluids thereto. Leaking connectors (184) connect the automated processor connection ports with inlet ports (196) of the device and allow a portion of the washing, decontaminant, and rinse solutions to leak from each inlet port. A computer control system (80) controls leak testing, cleaning, decontamination, rinsing, and drying stages of a cycle, which are all carried out within the chamber, obviating the need for human contact with the device during processing.

Abstract: A method of preserving two or more separately packaged agents for forming a silicone composition which can be cured by mixing the separately packaged agents, which method can reduce the number of air bubbles contained in a cured product of the silicone composition and prevent a reduction in the strength of the cured product. The method of preserving the composition is characterized by keeping each packaged agent of the curable silicone composition under reduced pressure.

Abstract: The present invention provides methods for preparing tissue for incorporation into xenografts and bioprosthetic devices. The methods of the invention make use of supercritical fluids to remove infectious materials and chemical agents from tissues, as well as to permeate a tissue with a chemical agent (e.g. tanning, cross-linking, and bioactive agents).

Abstract: Disclosed is a method of cleaning endoscopes within a container, wherein fluid flows from inside the container through the endoscope channels, predominantly in one direction, from the smaller-caliber end of an endoscope channel, or lumen, to the larger-caliber end. This method prevents the lodgment of particulate matter and human tissue in the smaller-caliber end of endoscope channels, and it allows fluid to flow through the entire length of all endoscope channels, to permit debris to exit the channels.

Abstract: A valve is provided which includes a valve body, a first valve member, and a second valve member. The valve body has a first flow passage formed therethrough and a second flow passage formed therein. The second flow passage has a smaller cross-sectional area than the first flow passage so that the valve can be used interchangeable between systems requiring different flow rates through the valve, and so that flow through the valve can be more accurately controlled than through the first flow passage alone.

Abstract: Disclosed are a pressure heating method and a pressure heating apparatus which can prevent deformation of articles or deterioration of the quality of the articles due to supply of excessive pressure and heat. After performing pressurizing and heating processing of articles by supplying steam to a pressure vessel, the supply of steam is stopped and air is supplied to the pressure vessel to keep the internal pressure of the pressure vessel within the range not exceeding the maximum value of the internal pressure at the time of pressurizing and heating. A cooling water spray device on a circulation pipe is operated along with a turbo blower so as to condense it for gradual removal. After completing the removal of the steam, the articles are cooled by the operation of the cooling water jet unit. By avoiding an abrupt decrease in the pressure inside the pressure vessel through preventing an instant condensation of the whole steam, an excessive pre-load becomes unnecessary at the final stage of sterilization.

Abstract: A system and a method for sterilizing a lumen device involve a container in a chamber and a source of germicide. The container has an interface separating the container into two compartments and a communication port which provides fluid communication between the container and the chamber. The lumen device extends across the interface, and the two compartments are in fluid communication with each other through the lumen device. The lumen device is sterilized when the germicide flows from compartment to compartment through the lumen device.

Abstract: A heat sterilization process for small, washed, and bagged articles such as vial stoppers includes a conditioning or air removal phase prior to sterilization. During the air removal phase, a substantial majority of the liquid moisture is removed from the bagged articles by introducing brief periods of dry, warm air to the autoclave chamber. The air is introduced in short bursts at the point of greatest vacuum while pressure pulsing the chamber during the air removal phase. The air is heated and injected into the chamber through a supply valve which is rapidly opened and closed while the chamber is maintained within a preselected vacuum range between the pressure pulses. The result is a greatly reduced time for a complete sterilization and drying process.

Abstract: A method of sterilizing an instrument having an exterior and a proximal end in a chamber of a sterilizing apparatus, the method including the following steps: washing the instrument with a rinse fluid; removing bio-burden from the instrument with a bio-burden removing fluid; stabilizing a sterilization temperature at which sterilization of the instrument occurs; sterilizing the instrument; a first rinsing of the instrument with the rinse fluid; and a first drying of the instrument. The sterilizing step includes: applying to the instrument a first application of a sterilizing fluid at a first predetermined flow rate and applying to the instrument a second application of the sterilizing fluid at a second predetermined flow rate. The first application includes a first predetermined sequence of pulses of the sterilizing fluid and a driving fluid. The second application includes a plurality of pulses of the sterilizing fluid.

Abstract: Devices and methods for sterilizing lumens involve a booster that is attached to the lumen. In preferred embodiments, the contact area between the lumen and the booster enhances the penetration of an antimicrobial agent to the contact area.

Abstract: A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.

Abstract: A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.

Abstract: The invention relates to a method for hydrogen peroxide plasma sterilization, wherein the chamber temperature is set at less than 39° C. throughout, and containers with temperature-sensitive products can be efficiently sterilized without the temperature-sensitive products showing a significant loss of activity or degradation.

Abstract: A product carrier for use in pressure processing substances is substantially fluidically closed, and is insulated, to prevent heat transfer from the product being treated to the cooler wall of the pressure vessel. The insulating material has compression heating properties, such that as the product is pressurized, the temperature of the insulation increases as does the temperature of the product and pressure media, thereby helping to prevent heat transfer from the product to the surrounding media and pressure vessel wall.

Abstract: A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized.

Abstract: An adjustable accumulator for delivering gases, liquids, or solids from a reservoir comprises an inner tube and a outer tube. One tube fits into the other tube to be sealingly engaged and to create a chamber in the interior. The tubes can move relative to each other to vary the space of the interior chamber. Another embodiment of the adjustable accumulator comprises the outer tube having a drum having a plurality of partitions. The drum partitions separate the drum into drum compartments. The drum partitions fit tightly against the inner tube. The drum compartments are in fluid communication with the interior of the inner tube when the inner tube is positioned such that a bottom edge of the upper tube is aligned with any drum partition that is at a higher level than the drum compartment or is between two drum partitions which form the drum compartment. The adjustable accumulator can be used to deliver vaporizable germicides to a sterilization chamber.

Abstract: A process is described for evacuating a reactor, in which at least one object is sterilized by means of Low pressure plasma. The reactor must be evacuated from atmospheric pressure to plasma discharge pressure. At least two separate, successive evacuation stages are hereby provided. In the first. evacuating stage and a possible further evacuation stage, the reactor is brought down step by step to a reduced intermediary pressure. In the last evacuation stage the reactor is evacuated to the plasma discharge pressure. For each evacuation stage it is advantageous to provide a separate vacuum chamber, to each of which the reactor is corrected. This brings with it the advantage that the entire amount of gas does not need to be transported through one single pump or a single set of pumps.

Abstract: Methods and apparatus are provided for decreasing the bacteria count of a food commodity without affecting its overall organoleptic quality (taste, odor, and color). This is accomplished using a treatment fluid comprising ozone, which is injected into a treatment chamber containing the food commodity. Some water is preferably added to obtain better contact of the ozone with the food by forming a thin film of ozonated water on the food surface. Spices and/or other ingredients may preferably be added with the water. The food is placed in a tumbler and the tumbler is set in motion. During treatment good contact between the treatment fluid and the food commodity is obtained by reversibly oscillating the tumbler. A log reduction of 40% or more in bacteria count may be obtained as compared without the ozone.

Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.

Abstract: A sequential delivery assembly (30) sequentially releases three different treatment materials into a fluid flow path (24) to form a treatment fluid with a composition which varies throughout a cleaning and microbial decontamination cycle. A chamber (12) receives items to be cleaned and decontaminated. A pump (22) pumps the treatment fluid from the sequential delivery assembly along a fluid flow line (24) to nozzles (16, 18) disposed within the chamber. The nozzles spray the treatment fluid over the items to be cleaned and decontaminated. The delivery assembly includes a well (34) for receiving a three compartment cup (44). The cup contains a first compartment (70) which includes a cleaning material (76), such as a detergent. A second compartment (72) contains pre-treatment materials (78), such as buffers and corrosion inhibitors, which prepare the system for receiving a microbial decontaminant (80), such as a concentrated solution of peracetic acid, contained in the third compartment (74).

Abstract: A method and apparatus is disclosed providing a plurality of sterile zones within a sterilization tunnel in an aseptic packaging apparatus. The sterile zones provide a plurality of sterilant concentration levels within the sterilization tunnel. Additionally, the sterile zones provide a plurality of gas flow rates within the sterilization tunnel.

Abstract: A gaseous blend of Ox and a method for significantly reducing the biological load, including anthrax, on mail and shipping parcels is disclosed. The gaseous blend of Ox consists at least in part of O3. The method involves applying a continuous stream of oxygen-containing, i.e., Ox, gas to the mail or shipping parcel at a predetermined temperature, pressure and relative humidity. The continuous stream of Ox gas is prepared in an Ox generation cell, which contains a means for generating the Ox gas at a pressure less than 20 lbs/in2 using, for example, one or more of the following: corona discharge, high frequency electrical discharge, ultraviolet light, x-ray, radioactive isotope and electric beam.

Abstract: A method for sterilizing the interior of the lumen, where a dry booster which does not contain liquid and which has a volume at least 2 times the volume of the lumen is attached to the end of the lumen. The lumen and dry booster are placed in a sterilization chamber, and germicide is introduced into the chamber. A higher pressure is created outside the booster than inside the booster. The empty dry booster draws germicide into the lumen, sterilizing the interior of the lumen. The method can be enhanced by reducing the pressure in the chamber before introducing the germicide.

Abstract: A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.

Abstract: An apparatus and associated method for decontaminating contaminated matter, such as an object or substance, with ultrasonic transient cavitation is disclosed. The apparatus comprises a container for containing a contaminated object, a pressure source for pressurizing the container to a predetermined pressure, a vibration source operably connected to the container, and a cleaning solution comprising a predetermined concentration of a volatile substance. The presence of the volatile substance in the cleaning solution, along with the pressurization and vibration thereof, enhances the effect of ultrasonic transient cavitation and improves decontamination of the contaminated matter.