Including Washing Means Patents (Class 422/510)
  • Patent number: 10358410
    Abstract: The invention relates to a thermal conversion vessel (200) used during amidification step of acetone cyanohydrin (ACH), in the industrial process for production of a methyl methacrylate (MMA) or methacrylic acid (MAA). The thermal conversion vessel (200) is used for converting an hydrolysis mixture of ?-hydroxyisobutyramide (HIBAM), ?-sulfatoisobutyramide (SIBAM), 2-methacrylamide (MACRYDE) and methacrylique acid (MAA), into a mixture of 2-methacrylamide (MACRYDE). at least one compartment (C1, C2, C3, . . . Ci) comprising an inner wall (206a, 206b, . . . 206i) separating said compartment into two communicating parts (C1a, C1b) by a passage provided between the bottom of said vessel and said inner wall, said compartment having a space above said inner wall, for separating gas phase from liquid phase during thermal conversion, said compartment being connected to an outlet valve (204a, 204b, . . . 204i). Such vessel allows obtaining a high yield thermal conversion in very safe conditions.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: July 23, 2019
    Assignee: Arkema France
    Inventors: Yves Bernardin, Xavier Marcarian, Romain Billon
  • Patent number: 10247726
    Abstract: Disclosed herein is a first responder hazardous material detection and isolation distance (HMDID) apparatus and method that addresses the disconnect that exists in two current first responder tools: a means for detecting a hazardous material, but also the need for an immediate action plan to secure a dangerous area and prevent harm to individuals, such as first responders present at an emergency scene. The detection apparatus comprises test membranes configured to detect a hazardous material present in the atmosphere, by producing a visual color change when exposed to air contaminated with the hazard. The test membranes are attached to a planar form, such as a flat paper card, and are accompanied by an isolation indicator and action item for isolating an area depending on the level of hazardous material present in the atmosphere.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: April 2, 2019
    Inventors: John R Zour, Chad Matthew McClintock
  • Patent number: 10119983
    Abstract: Described herein are sample manipulation devices, for removing lids from and/or for placing lids onto sample containers. Such devices include a sample unit including a sample carrier receptacle for receiving at least one sample carrier for holding one or more sample containers, and a manipulation unit having at least one manipulation tool, where the sample unit and the manipulation unit are movable relative to each other along a movement direction. The sample unit is also movable between a first orientation in which a longitudinal direction of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit, and a second orientation in which a transverse direction, which is orthogonal to the longitudinal direction, of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: November 6, 2018
    Assignee: HAMILTON BONADUZ AG
    Inventors: Peter Hoffmann, Martin Frey, Beat Zahner, Petra Tappe
  • Patent number: 10095842
    Abstract: Methods and systems for determining a set of control molecules for use in a combinatorial approach for the treatment of medical conditions, including providing one or more sets of control molecules, where each control molecule within the set acts on a set of targets and the number of control molecules within the one or more sets of control molecules is fewer than the number of targets within the sets of targets; and searching within the sets of control molecules to identify a subset of control molecules that together with a subset of targets form an artificial system to produce a biological effect through the modulation of the subset of targets.
    Type: Grant
    Filed: May 28, 2011
    Date of Patent: October 9, 2018
    Assignee: SALGOMED, INC.
    Inventors: Giovanni Paternostro, Jacob D Feala
  • Patent number: 10088659
    Abstract: A sample retaining member insertion-removal mechanism is configured so that a receiver is driven to an advance position by a receiver driving unit to project out through an opening of a stage so that a receiving surface makes a downward slope toward a receiving surface positioning portion. Because of this, the sample retaining member insertion-removal mechanism can position the sample retaining member by the receiving surface positioning portion through the use of the downward slope of the receiving surface by simply placing the sample retaining member on the receiving surface. After the positioning by the receiving surface positioning portion, the receiver is driven to a retraction position by the receiver driving unit, whereby the sample retaining member is transferred from the receiver to the stage.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: October 2, 2018
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Yasumoto Suzuki, Satoshi Watanabe
  • Patent number: 10078073
    Abstract: A package comprising a body comprising a first compartment containing a first substance and a second compartment containing a second substance. The package includes a first state in which the first compartment is isolated from the second compartment such that the first substance is separated from the second substance, and a second state in which the first compartment communicates with the second compartment such that the first substance and the second substance combine.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: September 18, 2018
    Assignee: Ecolab USA Inc.
    Inventors: Arthur J. Kahaian, Sasha J. Welz, Joe L. Schwartz, Adam J. Bauer, Lyle Sampson
  • Patent number: 10036395
    Abstract: A compressor control device includes an inlet guide vane opening degree control unit configured to control an opening degree of an inlet guide vane. The inlet guide vane opening degree control unit includes an inlet guide vane opening degree command value calculation unit configured to calculate an inlet guide vane opening degree command value based on an outlet pressure detection value and a plurality of inlet guide vane opening degree correction units each configured to correct the inlet guide vane opening degree command value based on the post-merger pressure detection value and a corresponding inlet flow rate detection value for each of a plurality of upstream-most compressor bodies.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: July 31, 2018
    Assignee: MITSUBISHI HEAVY INDUSTRIES COMPRESSOR CORPORATION
    Inventors: Kazuhiro Takeda, Yosuke Nakagawa, Hiroyuki Miyata, Naoki Mori
  • Patent number: 9952238
    Abstract: The present invention relates to a method of preparing analyses of total blood samples and to a device that is useful for implementing the method, said samples being conserved in tubes including at least one identification means for identifying the sample, the device comprising: at least one compartment constituting a said storage zone for storing said tubes before and after analysis; and at least one said read means for reading said identification means of said tubes; and at least one preparation zone for preparing said blood samples prior to analysis and including means for verifying and/or treating said tubes containing said samples, and in particular at least one agitator means for agitating said tubes; and at least one access zone giving access to at least one automatic analyzer of total blood, said access zone enabling a said tube to be placed in said analyzer; and robotic gripper and displacement means controlled by an automatic controller and suitable for taking hold of and replacing said tubes ind
    Type: Grant
    Filed: July 4, 2006
    Date of Patent: April 24, 2018
    Assignee: Horiba ABX SAS
    Inventor: Roger Le Comte
  • Patent number: 9943849
    Abstract: Sample tube racks having retention bars to retain sample tubes in the racks during processing of the contents of the sample tubes are described. An example rack for holding sample tubes includes a tube holder to hold the sample tubes in a substantially vertical orientation. A retention cover pivotally engages the tube holder at a first end and locks against the tube holder at a second end. The second end of the retention cover pivots relative to the tube holder about an axis that is non-parallel relative to a longitudinal axis of the retention cover while the first end of the retention cover is pivotally captured by the tube holder.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: April 17, 2018
    Assignee: Abott Laboratories
    Inventors: Brett W. Johnson, Kenneth E. Pawlak, Bryan K. Pawlak
  • Patent number: 9829476
    Abstract: For checking engine oil, especially containing rate of FAME (Fatty Acid Methyl Ester), we provide a measuring device including a cylindrical and upright analysis vessel having a reading scale with which a surface boundary is measured. In the vessel, the engine oil is mixed with reagents including alcohol(s) and a demulsifier. And the decreased volume is checked as volume of the FAME contained in the engine oil.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: November 28, 2017
    Assignee: YANMAR
    Inventors: Kay Kian Hee, Kamaruddin Kudumpor, Beverly Kah Waynee, Siti Norbaria Sally Bt. Pick Thall Tan, Aaron Willinton William
  • Patent number: 9645159
    Abstract: An automation system for use with an in vitro diagnostics environment includes a track and a plurality of carriers configured to move along the track and hold one or more of a plurality of samples and one or more of a plurality of reagents having reagent types. The system also includes one or more testing stations, one or more local reagent storage areas located at or proximate to the one or more testing stations and one or more central reagent storage areas. The system further includes a control system configured to direct the one or more reagents from the one or more local reagent storage areas to the one or more testing stations based on received reagent information and direct the one or more reagents from the one or more central reagent storage areas to the one or more testing stations based on the received reagent information.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: May 9, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Alexander Gelbman, Ryan German
  • Patent number: 9643185
    Abstract: Disclosed herein are high-throughput sample processing systems and waste management systems, and methods of using the same.
    Type: Grant
    Filed: April 9, 2016
    Date of Patent: May 9, 2017
    Assignee: Counsyl, Inc.
    Inventors: Kyle Allen Lapham, James Frederick Cregg, Daniel Delubac, Stuart Ira Glaser
  • Patent number: 9599630
    Abstract: The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: March 21, 2017
    Assignee: DAKO DENMARK A/S
    Inventors: Doug Sweet, Marc Key, Gordon Feingold, Kristopher Buchanan, Bob Lathrop, John Favuzzi
  • Patent number: 9409178
    Abstract: Processing containers include a first member having a substantially rigid body with a plurality of regions defining spaced apart workstations and a flexible barrier member sealably attached to the first member to define a closed chamber over the plurality of workstations. The flexible barrier is substantially impermeable and includes or is a manipulation tool that is sealably attached to the barrier. The manipulation tool has a first internal interface that resides in the closed chamber under the flexible barrier and a second external interface that resides outside the closed chamber. The processing containers are particularly suitable for automated processing of nucleic acids and other samples. The manipulation tool can cooperate with or include a pipette head. When the barrier is sealed, the barrier separates the contents of the container from a robotic arm or other manipulation device.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: August 9, 2016
    Assignee: Argos Therapeutics, Inc.
    Inventors: Simon Jonathon Spence, Richard Alexander Grant, Timothy Doyle Peele, William Samuel Hunter, Ashraf F. Abdelmoteleb, David Thomas Kneen, Robert Alister Neil, Simon Harris
  • Patent number: 9372148
    Abstract: A bond surface testing apparatus and method are presented. The bond surface testing apparatus comprises a solution chamber; a plurality of solution containers located in the solution chamber; a plurality of microfluidic pipettes; and an information capture module. Each solution container in the plurality of solution containers includes a microfluidic pipette in the plurality of microfluidic pipettes. A number of the plurality of microfluidic pipettes has a non-circular cross-section. The information capture module is physically associated with the solution chamber and is configured to capture information relating to bonding surface properties of the bonding surface.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: June 21, 2016
    Assignee: THE BOEING COMPANY
    Inventors: Eugene A. Dan-Jumbo, Joel Patrick Baldwin
  • Patent number: 9339817
    Abstract: Disclosed herein are high-throughput sample processing systems and waste management systems, and methods of using the same.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: May 17, 2016
    Inventors: Kyle Allen Lapham, James Frederick Cregg, Daniel Delubac, Stuart Ira Glaser
  • Patent number: 9267868
    Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: February 23, 2016
    Inventor: Lee H. Angros
  • Patent number: 9244087
    Abstract: The invention provides for a method of pipetting samples using a pipetting device including more than one pipetting unit. Each of the pipetting units are independently movable in Y and Z directions and includes an upper and a lower frame. Two adjacent pipetting units include a module arranged in a staggered manner in either of the respective upper and lower frames.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: January 26, 2016
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Alessandro D'Amore, Urs Knecht, Rolf Schneebeli
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 8999267
    Abstract: According to one embodiment, an automatic analyzer includes a reaction disc, cleaning mechanism, and cover. The reaction disc holds a cuvette which contains a sample and a reagent. The cleaning mechanism is configured to clean the cuvette using a nozzle. The cover is configured to be movable along an axis of the nozzle and to cover an opening of the cuvette.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: April 7, 2015
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Shoichi Kanayama
  • Publication number: 20150093786
    Abstract: The invention is related to a laboratory apparatus and method for the automated processing of liquid samples, in particular for the program controlled handling of liquid samples, having an electronic control device, which is adapted to process a program code for the program controlled processing of fluid samples, at least one processing space for receiving the fluid samples to be processed, at least one electronically controllable sample processing device for performing at least one program controlled process step on at least one sample, which is arranged in the processing space, at least one electronically controllable decontamination device for cleaning at least a part of the processing space, wherein the decontamination device is configured to be controlled by the control device and the control device is configured to digitally control the decontamination device.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 2, 2015
    Inventors: Andreas THIEME, Judith LUCKE, Rusbeh GOECKE, Manfred EBERS, Helmut KNOFE, Harald ANDRULAT
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Patent number: 8968680
    Abstract: A cleaning device that cleans a liquid storage part of a vessel for storing liquid. The cleaning device includes: a cleaning liquid discharge nozzle that discharges cleaning liquid to the liquid storage part; a first overflow suction nozzle of which tip is positioned above the tip of the cleaning liquid discharge nozzle, that sucks the liquid containing the cleaning liquid from the liquid storage part; a second overflow suction nozzle of which tip is positioned above the tip of the first overflow suction nozzle, that sucks the liquid containing the cleaning liquid from the liquid storage part; and a clog detecting unit that detects clog in one of the first and second overflow suction nozzles.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 3, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Kunihiko Mazume, Masato Kayahara, Tsutomu Ishikiriyama
  • Patent number: 8956579
    Abstract: A chemical dispensing system is provided having a micro-controller and at least one expansion module. The expansion module includes an expansion module interface. The expansion module is in communication with the micro-controller via the expansion module interface. The at least one expansion module expands capabilities of the chemical dispensing system beyond a base operation of the device.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 17, 2015
    Assignee: Delaware Capital Formation, Inc.
    Inventors: Wayne Yankee, David Howland, Scott Christa
  • Patent number: 8916113
    Abstract: An automatic chemical analyzer in which a reaction solution is stirred by air ejected from an air ejection hole placed above a reaction container. The reaction region can be washed and cleaned sufficiently without causing damage, such as exfoliation of a coating reagent. A reaction container disk 161 is provided with a pore 240 and a pressure detector 241 connected with the pore. Before and after the stirring operation, the ejection hole (nozzle) 170 ejecting air is moved and the output value of the pressure detector is compared with a previously measured normal value. With a discharge pipe 1101 and a suction pipe 1102 inserted to the opening of the reaction container 1140 to be close to both ends of the opening and the side wall of the container, the reaction region 1150 at the bottom of the container is washed by continuous discharge and suction of cleaning fluid.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: December 23, 2014
    Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Hironobu Yamakawa, Yoichi Aruga, Takenori Okusa, Kenichi Takahashi, Hans Hornauer, Hans-Juergen Mueller
  • Patent number: 8894949
    Abstract: A cleaning device includes a discharge nozzle that discharges cleaning liquid; a suction nozzle that sucks the cleaning liquid or reaction liquid in the cleaning tank or the reaction vessel; a discard vessel connected to the suction nozzle via a pipe to discard the cleaning liquid or the reaction liquid; a detecting unit that detects whether an electrostatic capacity at least between the suction nozzle and an electrode provided in the pipe exceeds a threshold value; a determination unit that determines that the suction nozzle is clogged when a time difference between a time, at which the electrostatic capacity exceeds the threshold value when the suction nozzle is not clogged, and a time, at which the electrostatic capacity exceeds the threshold value at the time of determination, is not less than a predetermined time difference threshold value; and a control unit that stops the discharge nozzle from discharging the cleaning liquid to the reaction vessel when the suction nozzle is clogged.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: November 25, 2014
    Assignee: Beckman Coulter, Inc.
    Inventors: Shinichi Inamura, Kenichi Kakizaki, Satoshi Nemoto
  • Patent number: 8894948
    Abstract: A cleaning device includes a discharge nozzle that discharges cleaning liquid; a suction nozzle that sucks the cleaning liquid or reaction liquid in the cleaning tank or the reaction vessel; a discard vessel connected to the suction nozzle via a pipe to discard the cleaning liquid or the reaction liquid; a detecting unit that detects whether an electrostatic capacity at least between the suction nozzle and an electrode provided in the pipe exceeds a threshold value; a determination unit that determines that the suction nozzle is clogged when a totalizing time, for which the electrostatic capacity exceeds the threshold value during a preset clogging determination time, is longer than a totalizing time, for which the electrostatic capacity exceeds the threshold value during a preset normal determination time; and a control unit that stops the discharge nozzle from discharging the cleaning liquid to the reaction vessel when the suction nozzle is clogged.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: November 25, 2014
    Assignee: Beckman Coulter, Inc.
    Inventors: Shinichi Inamura, Kenichi Kakizaki, Satoshi Nemoto
  • Patent number: 8858718
    Abstract: An automated method of cleaning the pipes of a plate washing system is provided. The plate washing system includes at least one manifold having a plurality of pipes configured to be provided within wells of a plate in order to wash the wells, an ultrasonic transducer mounted to a tank, and a control system. The plate washing system also includes sensors to sense the position of the pipes relative to plate and the tank, and the fluid level within the wells of the plate. The method includes dispensing fluid to the tank, submerging the tips of the pipes within the fluid, activating the ultrasonic transducer in order to vibrate the fluid, and aspirating the fluid from the tank. The control system may initiate a cleaning operation at the request of the user, at a scheduled interval, or when the level sensing system detects a decrease in instrument function.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: October 14, 2014
    Assignee: BTI Holdings, Inc.
    Inventors: Robert M. Gifford, Lenore Buehrer, Thomas A. Cleveland
  • Patent number: 8772036
    Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: July 8, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
  • Publication number: 20140186234
    Abstract: An automatic analysis apparatus according to an embodiment includes a dispensing probe, a cleaning unit, and a driving mechanism. The dispensing probe performs a dispensing operation for sucking a sample and discharging the sample into a reaction container. The cleaning unit cleans the dispensing probe. The cleaning unit includes a first cleaning position at which the dispensing probe is cleanable using a first cleaning liquid, and a second cleaning position which is located at a position lower than the first cleaning position and at which the dispensing probe is cleanable using a second cleaning liquid. The driving mechanism stops the dispensing probe at at least one of the first cleaning position and the second cleaning position.
    Type: Application
    Filed: March 5, 2014
    Publication date: July 3, 2014
    Applicants: Toshiba Medical Systems Corporation, KABUSHIKI KAISHA TOSHIBA
    Inventors: Reiko MARUYAMA, Shoichi KANAYAMA
  • Publication number: 20140178251
    Abstract: A sample analyzer comprises a container setting part on which a liquid container is to be set, a liquid supplying part configured to supply a liquid to the liquid container, an aspiration tube configured to aspirate a sample or a reagent, a movement mechanism configured to move the aspiration tube, a liquid surface sensor configured to detect contact of the aspiration tube with a liquid surface, and a controller configured to execute an aspiration tube adjustment operation. The aspiration tube adjustment operation comprises supplying the liquid to the liquid container by the liquid supplying part, lowering the aspiration tube by the movement mechanism toward the liquid container set on the container setting part, and obtaining information regarding a position in a height direction of the aspiration tube at a time when the aspiration tube has come into contact with the liquid surface.
    Type: Application
    Filed: December 19, 2013
    Publication date: June 26, 2014
    Applicant: Sysmex Corporation
    Inventors: Miyuki YAMADA, Shuji KAWAGUCHI, Hiroshi KURONO
  • Patent number: 8759106
    Abstract: A clinical tester has been described that includes a probe to aspirate a fluid. The probe is washed between aspirations to reduce carryover. The wash operation includes both an internal and an external wash, where the internal wash operation is terminated prior to terminating the external wash. In one embodiment, the probe wash can be implemented on an integrated clinical chemistry/immunoassay tester.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: June 24, 2014
    Assignee: Abbott Laboratories
    Inventors: Patricia H. Ravalico, Charlie W. Wilson, III
  • Patent number: 8758702
    Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 24, 2014
    Assignee: Instrumentation Laboratory Company
    Inventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
  • Patent number: 8758705
    Abstract: The dispenser includes a dispensing head extending downward from a cylinder body section with a cylindrical inner space and having a dispensing cylinder with the diameter smaller than that of the inner space of the cylinder body section; a piston capable of being inserted from the inner space of the cylinder body section into the dispensing cylinder section and moving up and down between a dispensing start position located in an upper portion of the dispensing cylinder section and a dispensing end position in a lower portion of the dispensing cylinder section; and a sucking mechanism sucking a liquid from a dripping port at a tip of the dispensing cylinder section up to a position above the dispensing start position inside the inner space of the cylinder body section. The piston is always at the dispensing start position under a liquid surface whenever the dispensing operation is started.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 24, 2014
    Assignee: Medicatec Kabushiki-Kaisha
    Inventor: Hiroyasu Tsukioka
  • Publication number: 20140106467
    Abstract: A pipetting unit and a method of using the pipetting unit for pipetting a volume V1 of test liquid for carrying out an in vitro diagnostic test are presented. The method comprises dipping a nozzle of a pipetting unit into a test liquid and aspirating a volume V4 of the test liquid larger than the volume V1 required for carrying out the test. The method further comprises dipping the pipetting unit into a wash liquid and dispensing a volume V2 equal or smaller than V4 minus V1 of the test liquid into the wash liquid. The method further comprises dipping the pipetting unit into a reaction liquid and dispensing the volume V1 of test liquid required for the test.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 17, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Roland Hutter, Roland Stoeckli
  • Patent number: 8697012
    Abstract: A high-speed automatic dispensing apparatus capable of preparing samples under different conditions, minimizing waste liquid materials, and realizing high productivity. A dispensing station is also provided. The high-speed automatic dispensing apparatus with a replaceable dispensing head comprises a dispensing head including a plurality of pipettes, a pipette head to which one end of a plunger extending to pass through each pipette is fixed, and a head body part abutting against the pipette head and allowing the pipettes to pass therethrough, a pipette head moving mechanism vertically moving the pipette head, and a drive mechanism horizontally and vertically moving the dispensing head. The dispensing station includes the high-speed automatic dispensing apparatus.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: April 15, 2014
    Assignee: Musashi Engineering, Inc.
    Inventor: Kazumasa Ikushima
  • Patent number: 8697011
    Abstract: The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member for acquiring or dispensing a sample; and a supply of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: April 15, 2014
    Assignee: Stokes Bio Limited
    Inventors: David McGuire, Kieran Curran, Julie Garvey, Damian Curtain
  • Patent number: 8679262
    Abstract: A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: March 25, 2014
    Assignee: Aushon Biosystems
    Inventors: Peter Honkanen, Albert Bukys, Dave Bradbury
  • Patent number: 8663579
    Abstract: This invention provides a biological component-measuring device, enabling the operator to easily calibrate the entire device and capable of measuring biological components accurately, and a method for calibrating the device. The device measures a sample including a body fluid taken through a body fluid sampler by sending it with a pump through a sample channel to a sensor. The device further includes a calibrating liquid channel through which a calibrating liquid can be supplied to the sensor via the sample channel by a switching of a first flow path changeover valve placed in the sample channel at a location upstream of the pump and connected to the channel. The method includes introducing the calibrating liquid in the calibrating liquid channel, via other channels, into the sensor by switching the valve.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: March 4, 2014
    Assignee: Nikkiso Co., Ltd.
    Inventor: Motoaki Murakami
  • Patent number: 8652407
    Abstract: A self-contained assay device that is capable of detecting various analyte(s), including bioanalytes, in specimens for example, from biological sources.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: February 18, 2014
    Assignee: PalmStat Diagnostics, LLC
    Inventors: Pete Wilson, Eric Butt, Vincent Mata
  • Patent number: 8545760
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 1, 2013
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 8501096
    Abstract: An apparatus and method for the automated preparation of treated monolayers of sample material, comprising: a centrifuge having a rotor (12) carrying removable chamber blocks (14); sample and reagent dispensers (26) and control systems (20). First, centrifugal force sediments sample material discretely to form a monolayer onto a receiving surface member (32) on one of the chamber blocks (14), while the same centrifugal force opens a valve (48) in the chamber block (14) to drain sample material. Then, centrifugal force delivers sequentially into discrete chamber blocks (14) discrete treating agents, during which time the sampler material monolayer is held in place on the receiving surface member (32) by centrifugal force. Then, each chamber block (14) is drained centrifugally through its already opened valve (48). Each treated sampler material is confined to an individual chamber block (14). Batch and random access delivery of treating agents can be employed.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: August 6, 2013
    Inventor: Robert Cary Leif
  • Publication number: 20130108521
    Abstract: The discharge device includes a nozzle unit, a storage unit for supplying a pressure transmission medium under regulated pressure to the nozzle unit side, a pressurization unit for supplying a pressurized gas under regulated pressure to the storage unit side, a pump mechanism, a branch unit for communicating the nozzle unit, the storage unit, and the pump mechanism with each other, a discharge valve for establishing or blocking communication between the branch unit and the nozzle unit, and a supply valve for establishing or blocking communication between the branch unit and the storage unit. In a state of the discharge valve being closed and the supply valve being opened, the pressurized gas under pressure regulated by the pressurization unit is supplied to the storage unit side and the pressure transmission medium in liquid phase under pressure regulated by the storage unit is supplied to the supply valve side.
    Type: Application
    Filed: March 24, 2011
    Publication date: May 2, 2013
    Applicant: MUSASHI ENGINEERING, INC.
    Inventor: Kazumasa Ikushima
  • Patent number: 8361387
    Abstract: A method and system for automatically processing of liquid samples involving mixing of the samples with fluids are disclosed. The system includes a storing and handling device for storing and handling of fluid containers, which includes: a storing member provided with a plurality of storing positions, adapted for accommodating the fluid containers, the storing member having at least two storing levels, each of which extending in a plane, which are being stacked in a direction orthogonally aligned to the plane; and a handler, adapted for automatically transferring the fluid containers at least with respect to the storing positions. A method for operating such storing and handling device is also disclosed, wherein individual fluid containers are transferred between storing positions of a same or different storing levels in accordance with processing of the liquid samples.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: January 29, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gottlieb Schacher, Rolf Sigrist
  • Patent number: 8354078
    Abstract: The present invention is to present a liquid dispensing apparatus which is capable of preventing contamination by previously aspirated liquid, even when residual liquid in a pipette tip separated from the dispensing apparatus is scattered. The liquid dispensing apparatus includes: sample dispensing arm 5 which comprises a dispensing nozzle 54b for aspirating and discharging sample on which a pipette tip 200 is attached; tip separating section 140 for separating the pipette tip 200 from the dispensing nozzle 54b; and nozzle wiping section 16 for cleaning a tip of the dispensing nozzle 54b.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: January 15, 2013
    Assignee: Sysmex Corporation
    Inventors: Keiichiro Shohmi, Tomoyuki Nishida, Yoshinori Ooi
  • Patent number: 8246760
    Abstract: A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: August 21, 2012
    Assignee: Aushon Biosystems
    Inventors: Peter Honkanen, Albert Bukys, Dave Bradbury
  • Patent number: 8152930
    Abstract: Method and apparatus for removing residual material from sample wells of a multiwell plate. Wells located on a multiwell plate are placed in fluid communication with wash wells of a wash reservoir where cleaning fluid is provided to remove residual material from the sample wells of the multiwell plate.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: April 10, 2012
    Assignee: Protedyne Corporation
    Inventor: Peter Massaro
  • Patent number: 8147775
    Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: April 3, 2012
    Assignee: CFD Research Corporation
    Inventors: Sivaramakrishnan Krishnamoorthy, Jianiun Feng
  • Publication number: 20120074165
    Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 29, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jonathan SCHULTZ, David Marran
  • Patent number: 8119081
    Abstract: A specimen analysis method, comprising: bringing a first specimen vessel to a sucking position for sucking specimens; obtaining a first measurement result of a first specimen contained in the first specimen vessel; bringing a second specimen vessel to the sucking position before the first measurement result is obtained; obtaining a second measurement result of a second specimen contained in the second specimen vessel; bringing a third specimen vessel to the sucking position after the first measurement result is obtained; obtaining a third measurement result of a third specimen contained in the third specimen vessel; and obtaining a fourth measurement result of the second specimen when the first measurement result is higher than a threshold, the second specimen being sucked at the sucking position again for obtaining the fourth measurement result before bringing the third specimen vessel to the sucking position, is disclosed. A specimen analysis is also disclosed.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: February 21, 2012
    Assignee: Sysmex Corporation
    Inventors: Yousuke Tanaka, Masayuki Ikeda, Takamichi Naito