Automated System Patents (Class 422/509)
  • Patent number: 10416046
    Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: September 17, 2019
    Assignee: RareCyte, Inc.
    Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
  • Patent number: 10234474
    Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: March 19, 2019
    Assignee: HandyLab, Inc.
    Inventors: Jeff Williams, Kerry Wilson
  • Patent number: 10118339
    Abstract: Technologies are provided herein for a modular deposition tool design that allows for both, the fast interchanging of materials and for easy cleaning of all wetted surfaces. A drive assembly for use in a solid freeform fabrication system, includes a drive module having a drive mechanism and a detachable material bay assembly that is detachable from the drive module. The material bay assembly includes a material bay holder, a material deposition tool, and a corresponding material bay actuation mechanism that can engage with the drive mechanism of the drive module when the material bay assembly is coupled to the drive module such that when the drive mechanism of the drive module is actuated, the material bay actuation mechanism is actuated, which causes the material deposition tool to deposit material from a material bay inserted in the material bay holder.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: November 6, 2018
    Inventors: Jeffrey I. Lipton, Hod Lipson, Daniel Lawrence Cohen
  • Patent number: 10119892
    Abstract: An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: November 6, 2018
    Inventors: Toshiyuki Kasamatsu, Noboru Horikoshi
  • Patent number: 10001500
    Abstract: A pipetting arrangement includes at least two sets of pipettes (9a; 9b; 9c; 9d). Each set of pipettes (9a; 9b; 9c; 9d) is operationally connected, via a controllable ON/OFF valve (11a; 11b; 11e; 11d) to a common aspiration port (7). Latter is connectable to a pumping arrangement. The valves (11a; 11b; 11e; 11d) are controlled by a timing-control unit (15) conceived to establish, by control of the valves (11a; 11b; 11e; 11d), the operational connections of the at least two sets of pipettes (9a; 9b; 9c; 9d) to the aspiration port (7) in a time-multiplexed manner.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: June 19, 2018
    Assignee: Tecan Schweiz AG
    Inventor: Pius Fink
  • Patent number: 9964558
    Abstract: Dilution of a sample occurring in a sample dispensing operation is a problem in terms of analysis accuracy. Although the dilution amount is alleviated to some extent by a technique of sucking the sample excessively, the problem may emerge along with a requirement for reducing the sample dispensing amount, an increase of sucking and discharging speed in response to improvement of a processing capability, and an increase of the number of items to be analyzed simultaneously. Provided is an automatic analyzer including a mechanism monitoring conductivity of system water filled in a nozzle and an electro-physical amount such as voltage and capacitance of a probe to enable detection of mixture of the sample and a reagent into the system water and dilution of the sample and the reagent.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: May 8, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Gorou Yoshida
  • Patent number: 9915648
    Abstract: The invention relates to a method of analysing a sample, comprising the analysis of clinical-chemical parameters and the analysis of immunodiagnostic parameters in a fully automatic analysis apparatus, wherein the analysis apparatus comprises a pipetting apparatus, at least one holder for a reagent cartridge containing the components necessary for carrying out the analysis, a holding apparatus for a measurement cell, at least one measurement cell, with each reagent cartridge being associated with a measurement cell, a holding apparatus for a sample container containing sample, and a photometric or spectrometric measurement device. On the basis of a sample it is possible here for a plurality of different clinical-chemical and/or immunodiagnostic parameters to be determined, to which end a dedicated reagent cartridge is inserted into a holding apparatus of the analysis apparatus for each clinical-chemical or immunodiagnostic parameter to be determined.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: March 13, 2018
    Inventors: Alfred Janetzko, Wilhelm Sänger, Cyril E. Geacintov
  • Patent number: 9897623
    Abstract: Disclosed is an automatic analyzer that analyzes a component of a target layer of a test sample separated into a plurality of layers by transferring the component from an installed container, including: a dispensing probe that descends into the target layer and suctions the component; a detecting unit that detects the height of the layer surface of the target layer of the test sample; a calculating unit that calculates the depth from the layer surface of the target layer at which the total content of the component of the target layer reaches a target amount; and a controller that causes the dispensing probe to descend to the depth calculated by the calculating unit and suction the component.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: February 20, 2018
    Assignee: Toshiba Medical Systems Corporation
    Inventors: Kanako Iwamura, Shoichi Kanayama, Nobuyasu Kobayashi
  • Patent number: 9897519
    Abstract: When the type is to be changed from serum (preceding sample) to urine (current sample), “serum” is set to a preceding type and “urine” is set to a measurement type at number 1 in a condition number. At condition number 1, the wash type is pattern 1, with washing performed once with detergent 1. Where the preceding sample is serum and the current sample is CSF, the condition number is 2 and the wash type is pattern 2, with washing performed twice using detergent 1 and once with detergent 2. Where the preceding sample is urine and the current sample is CSF, the condition number is 3 and the wash type is pattern 3, with washing performed once with detergent 1, once with detergent 2, and once with water. In the case of pattern 4, washing is performed three times with detergent 1.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: February 20, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Naoto Suzuki, Yoshiaki Saito, Yoichi Aruga, Toshihide Orihashi, Kazuhiro Nakamura
  • Patent number: 9863905
    Abstract: The invention relates to a method for detecting contact of a pipetting needle in an in vitro diagnostic system. To this end, the pipetting needle, in an advantageous embodiment of the invention, should be cyclically charged by an electric voltage or current applied between the pipetting needle and a reference potential and discharged again by a subsequent electric connection between the pipetting needle and the reference potential. A characteristic variable for the current capacitance between the pipetting needle and the reference potential should be established from a number of measured values detected during the charging and/or discharging. A temporal curve of the characteristic variable should be monitored continuously based on a number of predetermined criteria and a contact signal should be generated if the predetermined criteria are satisfied.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 9, 2018
    Inventor: Alexander Wiedekind-Klein
  • Patent number: 9817013
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: November 14, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 9753047
    Abstract: A positioning system for a sample analysis device is disclosed. The positioning system comprises (1) a carousel comprising a platform and a sample loading tray mounted on the platform, and (2) a stage comprising a positioning system for positioning the carousel under the optical path of an imaging system. The sample loading tray is configured for holding a cartridge comprising one or more lateral flow cells (LFCs).
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: September 5, 2017
    Inventors: Christopher Cooney, Alexander Perov, Arial Bueno, Charles Daitch
  • Patent number: 9740889
    Abstract: A method for accurately positioning a computer position, and identifying a specific rack position where the computer is without manual intervention. A camera is installed on the computer to read the contents of a tag on the rack, so as to identify the position information of the computer. Specifically, the computer is provided with a self-positioning function, wherein: a camera is installed on the computer, and the camera is configured to read the contents of a tag attached on a side of a rack to house the computer to identify the rack position where the computer is.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: August 22, 2017
    Assignee: International Business Machines Corporation
    Inventors: Yan Li, Hai Bo Lin, Tao Liu, Yu Dong Yang, Yi Xin Zhao
  • Patent number: 9733115
    Abstract: The present invention improves the technology for detecting the level of a reagent in a container using changes of the capacitance, for instance, of an aspiration tube for aspirating the reagent from the container. The present invention can eliminate noises to detection of the capacitance caused by metals surrounding the container and changes of the moving speed of aspiration tube. Changes of the capacitance are detected using an empty container and recorded. The recorded changes are subtracted from changes of the capacitance measured with a container containing a reagent to eliminate the noises to the detection of changes of the capacitance.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: August 15, 2017
    Inventor: Takayuki Endo
  • Patent number: 9709586
    Abstract: To provide an automatic analyzer which is not influenced by fluidity or viscosity of a sample, and which can stably dispense the sample with dispensing accuracy by determining whether a flow route including a sample probe is in a stable and suction-available state when the sample is suctioned. In suction of the sample, before the sample is suctioned, in the flow route including the sample probe, the automatic analyzer determines whether the sample is in a suction-available state or in a suction-unavailable state, and performs cleaning on the flow route when it is determined that the sample is not in the suction-available state. Since the state in the flow route including the sample probe is determined before the sample is suctioned, the automatic analyzer can repeatedly perform a dispensing operation having improved reliability, without being influenced by the fluidity or the viscosity.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: July 18, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takamichi Mori, Kazuhiro Nakamura, Yoshihiro Suzuki
  • Patent number: 9579646
    Abstract: An automated multi-function processing head for a laboratory work station having a table for supporting microtiter plates, other fluid receptacles, a movable arm, and a dual tip dispensing head affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including sample pipetting, serial dilution, reagent additions, mixing, reaction timing and washing of reaction vessels. The work station is adapted to transfer, dispense and aspirate liquid from one location to another automatically in accordance with user programmed instructions. Fluid is dispensed and aspirated using a dual tip dispensing head having two sets of tip couplers actuated by one drive system. The two sets of tip couplers allow the use of different sizes of pipette tips and tips at different pitches or distances between the centerlines.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: February 28, 2017
    Assignee: ACCEL BIOTECH, INC.
    Inventor: Bruce J. Richardson
  • Patent number: 9557269
    Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 31, 2017
    Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
  • Patent number: 9440234
    Abstract: This disclosure is directed to a slide for analyzing target analytes of a suspension. The slide can be used to collect and hold the target analyte for imaging or further processing. The slide comprises a well section, including wells into which the target analyte can be stored. The wells may be removable and sized to fit into a second apparatus, such as a PCR thermocycler, for additional processing. Alternatively, the wells may hold processing vessels, such as PCR tubes, the processing vessels being used for downstream processing and/or analysis.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: September 13, 2016
    Assignee: RareCyte, Inc.
    Inventors: Joshua Nordberg, Jennifer Chow, Daniel Campton, Jonathan Lundt
  • Patent number: 9352414
    Abstract: A laser processing method having a displacement acquiring step of acquiring a displacement between a point on the cutting line and one end of the cutting line in the object while irradiating the object with a second laser beam, converged by a lens, for measuring the displacement of a main surface of the object; and a position setting step of setting an initial position for holding the lens with respect to the main surface of the object according to the acquired displacement, and holding the lens at thus set initial position.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: May 31, 2016
    Inventors: Kazuhiro Atsumi, Koji Kuno, Masayoshi Kusunoki, Tatsuya Suzuki
  • Patent number: 9315334
    Abstract: An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. A central management controller can communicate wirelessly with the carriers to direct the carriers to carry a fluid sample to testing stations along a track within the automation system. The carriers control local motion and navigate decision points, such as forks in the track, to reach the appropriate testing station independently. The carriers can utilize landmarks and distance encoding to reach destinations accurately and quickly, including, for example, within less than the time for a single operation cycle of an automated clinical analyzer.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: April 19, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Colin Mellars, Baris Yagci, Benjamin Pollack
  • Patent number: 9314788
    Abstract: A specimen identification and dispensation device includes an optical measurement device which is an identification part for measuring and identifying optical information on a specimen by emitting exciting light to the specimen being a measurement target dispersed in a liquid flowing through inside of a capillary, a dispensation part for dispensing the identified specimen into wells being sections to be dispensed through a nozzle, and a concentration adjustment part which adjusts the number of the specimens contained in an aliquot solution to a desired number according to the concentration of a sample liquid and the amount of the aliquot solution. The dispensation part is movable three-dimensionally with respect to the identification part and the nozzle.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: April 19, 2016
    Inventors: Toru Takahashi, Jie Xu, Ken Tsukii
  • Patent number: 9227188
    Abstract: This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 5, 2016
    Assignee: RARECYTE, INC.
    Inventors: Steve Quarre, Ronald Seubert
  • Patent number: 9207229
    Abstract: In one embodiment, a biosample storage cartridge includes an enclosure having a same form factor as a data tape cartridge configured for use in an automated tape library; and a holder disposed in the enclosure. In another embodiment, a biosample storage cartridge includes an enclosure and a holder disposed in the enclosure; the holder is configured to receive one or more biosamples, the cartridge is structurally configured to be picked by a picker of an access robot that is configured to pick a data tape cartridge in an automated tape library. In still another embodiment, an analytical system includes a bioanalysis drive configured to perform bioanalysis on one or more biosamples received from at least one biosample storage cartridge.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: December 8, 2015
    Assignee: International Business Machines Corporation
    Inventors: Allen K. Bates, Nils Haustein, James W. Johnson, Stephen L. Schwartz, Anna W. Topol, Daniel J. Winarski
  • Patent number: 9194866
    Abstract: Each of a first measurement unit and a second measurement unit (sample analyzer) includes: a reagent storage section in which a plurality of holder parts are arranged side by side, each of the holder parts including a setting part in which a reagent container having an RFID tag attached thereto is set, and an antenna part which transmits/receives a radio wave to/from the RFID tag of the reagent container set in the setting part; and a left face part and a right face part which block a radio wave communication path between the antenna part of one of the holder parts and the RFID tag of the reagent container set in another one, of the holder parts, adjacent to the one of the holder parts.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: November 24, 2015
    Inventors: Nobuhiro Kitagawa, Yuichi Hamada, Takaaki Nagai
  • Patent number: 9134335
    Abstract: A needle for handling a fluid in an analysis system is described. The needle includes a needle body made of a ceramic material and having a fluid conduit extending between a fitting end and a seat end. The fitting end is configured to be connected to a fitting and the seat end (308) being insertable into a seat. The needle body is tapering towards the fitting end. A fixing body is arranged on the needle body next to the fitting end for exerting an axial force when the needle body is connected to the fitting, and a slide-on element to be slid over the needle body so as to push the fixing body towards the fitting end.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: September 15, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Bernhard Dehmer, Joachim-Richard Wagner
  • Patent number: 9134334
    Abstract: A sample is contained in a sample container and a physical relationship between the sample and a sample ID thereof is established. However, after the sample ID is read by a bar code reader and the sample is transferred to an analysis-dedicated small sample container, the sample ID and the sample are separated from each other. Following the end of analysis, therefore, the sample ID must be merged with a corresponding analysis result. A read/write-enable ID carrier is provided on an analysis-dedicated sample container into which the sample is pipetted or on a tank for holding the analysis-dedicated sample container. When the sample is pipetted or when the analysis-dedicated sample container is moved, the sample ID and other information are transferred to the read/write-enable ID carrier.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 15, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Yoshiro Gunji
  • Publication number: 20150147820
    Abstract: A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir. The local reservoir for storing a bulk liquid for impending use can be a trough. The use of troughs for storing a reagent, a diluent, or some other treating agent for impending use enables an aspirating/dispensing device having a plurality of pipettes to aspirate and dispense the reagent,diluent, or other treating agent at a high rate of throughput. The controller can monitor the level of a liquid in (a) a local reservoir for storing a bulk liquid for imminent use and the level of liquid in a (b) container for holding a bulk liquid before the liquid is transferred to a local reservoir.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventors: Patrick P. Fritchie, Gregory E. Gardner, Richard W. Mahoney
  • Patent number: 9039998
    Abstract: Bioprinting station (1) comprising:—a Bioprinting device (4) adapted to deposit a pattern of biological material (2) onto an area of interest (3a) of a substrate (3),—an imaging system (15) adapted to acquire an image of the substrate (3) and to reveal on the acquired image the area of interest (3a) with respect to a remaining part (3b) of the substrate (3), the acquired image of the substrate (3) being processed so as to detect the revealed area of interest (3a) on the acquired image and to determine the pattern corresponding to the area of interest (3a) detected on the acquired image.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: May 26, 2015
    Assignee: Institut National de la Sante et de la Recherche Medical (INSERM)
    Inventors: Fabien Guillemot, Sylvain Catros, Virginie Keriquel, Jean-Christophe Fricain
  • Publication number: 20150140669
    Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 21, 2015
    Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thursten Brueckner, Timo Klein
  • Publication number: 20150139867
    Abstract: A liquid measuring unit includes a first capillary tube, a second capillary tube, and a holding portion that holds the first capillary tube and the second capillary tube, wherein a distance between a liquid contact portion of the first capillary tube and the holding portion is longer than a distance between a liquid contact portion of the second capillary tube and the holding portion.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventor: Makoto Ogusu
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9011796
    Abstract: A device for analysing a clinical sample comprises at least one depot chamber for receiving one or more reagents and at least one process chamber, whereas the process chamber is integrated in a first support member and the depot chamber is integrated in at least a second support member, whereas the support members are arranged in that the process chamber is connectable with the depot chamber by a relative movement of the first and second support member with respect to each other. According to the invention, the device further includes a pump element for transferring the substances inside the device from one chamber to another.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: April 21, 2015
    Assignees: Carpegen GmbH, Systec Elektronik und Software GmbH
    Inventors: Max Koltzscher, Antje Rötger, Krzysztof-Wlodzimierz Siemieniewicz, Jens Heitmann, Christoffer Mai, Klaus-Gerd Schoeler, Tilmann Wolter
  • Patent number: 9011799
    Abstract: The invention relates to a laboratory sample instrument with a cable holding space in which a printed circuit board cable device is arranged. The printed circuit board cable device has at least one printed circuit board with first and second sides and, arranged in succession, at least one first circuit board section, at least one second circuit board section and at least one third circuit board section, and with a number of conductor tracks arranged in parallel with respect to one another and extending from a first track section arranged in the first circuit board section, via the second circuit board section to the third circuit board section, in which a second track section is arranged, wherein, in the second circuit board section, at least one conductor track is arranged on the first side of the board and at least one track is arranged on the second side.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 21, 2015
    Assignee: Eppendorf AG
    Inventor: Burkhardt Reichmuth
  • Patent number: 9012236
    Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 21, 2015
    Assignee: IntegenX Inc.
    Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Omar El-Sissi
  • Patent number: 8999266
    Abstract: A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: April 7, 2015
    Assignee: Agena BioScience, Inc.
    Inventors: Xian-Wei Yao, Chao Lin, Paul Heaney, Thomas Becker, Aaron A. Hanson, Michael C. Willis
  • Publication number: 20150086970
    Abstract: Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.
    Type: Application
    Filed: May 3, 2012
    Publication date: March 26, 2015
    Applicant: Qualigen, Inc.
    Inventor: Michael Poirier
  • Patent number: 8986614
    Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 24, 2015
    Assignee: Rheonix, Inc.
    Inventors: Peng Zhou, Lincoln C. Young, Benjamin Thomas, Zongyuan Chen, Todd Roswech, Gwendolyn Spizz, Rubina Yasmin, Greg Mouchka
  • Patent number: 8986629
    Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: March 24, 2015
    Assignee: Genia Technologies, Inc.
    Inventors: Kevin Deierling, Roger J. A. Chen, David J. Fullagar
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Patent number: 8980184
    Abstract: The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein; the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: March 17, 2015
    Assignees: ABX Advanced Biochemical Compounds GmbH, Gesim—Gesellschaft fuer Silizium-Mikrosysteme mbH
    Inventors: Marco Mueller, Steffen Howitz
  • Patent number: 8974750
    Abstract: A nozzle device which can perform accurate quantitative suction without being affected by a pressure when, for example, a nozzle (2) is inserted into a closed container (T). The nozzle device has the nozzle (2) that is inserted into the closed container (T) and that sucks a liquid in the closed container (T), an exposure to atmosphere mechanism (3) that opens the closed container (T) to the atmospheric air, and an opening/closing structure (4) that is arranged at a proximal end of the nozzle (2) and that has an internal flow channel (411) communicated with a flow channel in the nozzle (2) and an opening/closing mechanism for opening and closing the internal flow channel (411), and an opening/closing control section (5) that controls the opening/closing mechanism.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: March 10, 2015
    Assignee: Horiba, Ltd.
    Inventors: Soichi Oue, Yoshihiro Yano, Narihiro Oku
  • Patent number: 8968680
    Abstract: A cleaning device that cleans a liquid storage part of a vessel for storing liquid. The cleaning device includes: a cleaning liquid discharge nozzle that discharges cleaning liquid to the liquid storage part; a first overflow suction nozzle of which tip is positioned above the tip of the cleaning liquid discharge nozzle, that sucks the liquid containing the cleaning liquid from the liquid storage part; a second overflow suction nozzle of which tip is positioned above the tip of the first overflow suction nozzle, that sucks the liquid containing the cleaning liquid from the liquid storage part; and a clog detecting unit that detects clog in one of the first and second overflow suction nozzles.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 3, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Kunihiko Mazume, Masato Kayahara, Tsutomu Ishikiriyama
  • Publication number: 20150056111
    Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Inventors: Carsten Haack, Thomas Engel, Tobias Holenstein
  • Patent number: 8961905
    Abstract: An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 24, 2015
    Assignee: Lenovo Enterprise Solutions (Singapore) Pte. Ltd.
    Inventors: Govindarajan Natarajan, Emmanuel Delamarche, Eric A. Eckberg, James N. Humenik, Kathleen A. McGroddy-Goetz, Scott Partington, Christopher F. Perrera, Marco G. Trivella, Timothy M. Wiwel
  • Publication number: 20150050719
    Abstract: A dispensing assembly comprising a cartridge holder is presented. The cartridge holder can receive a cartridge for dispensing a fluid. The cartridge can comprise a reservoir for receiving the fluid. The reservoir can comprise an outlet. The reservoir can have an adjustable volume for forcing the fluid through the outlet. The cartridge can further comprise a nozzle for dispensing the fluid. The nozzle can be connected to the outlet. The dispensing assembly can further comprise an actuator for actuating the adjustable volume. The dispensing assembly can further comprise an impulse generator for imparting an impulse to the nozzle. The impulse generator can comprise an actor for contacting the nozzle. The dispenser assembly can further comprise a controller for controlling the actor and the impulse generator.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 19, 2015
    Inventors: Stefan Borja Bammesberger, Andreas Ernst, Peter Koltay, Nadine Losleben, Laurent Tanguy
  • Patent number: 8956579
    Abstract: A chemical dispensing system is provided having a micro-controller and at least one expansion module. The expansion module includes an expansion module interface. The expansion module is in communication with the micro-controller via the expansion module interface. The at least one expansion module expands capabilities of the chemical dispensing system beyond a base operation of the device.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 17, 2015
    Assignee: Delaware Capital Formation, Inc.
    Inventors: Wayne Yankee, David Howland, Scott Christa
  • Patent number: 8951023
    Abstract: Pumping systems and methods for delivering a plurality of different pumpable materials serially at a location at substantially the same flow rate includes a plurality of diaphragm pumps, wherein each diaphragm pump has a first chamber for receiving a hydraulic fluid from a first and/or second hydraulic fluid source and a second chamber for receiving a material to be pumped from one of a plurality of pumpable material sources. A sensor is provided for detecting the pressure of the hydraulic fluid in each of the first chambers of the plurality of diaphragm pumps and is operable to activate the source of hydraulic fluid to ensure that the hydraulic fluid in each of the first chambers of the plurality of diaphragm pumps has an equivalent pressure.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: February 10, 2015
    Assignee: Stratabolt (Proprietary) Limited
    Inventor: Donald Michael O'Connor
  • Publication number: 20150037227
    Abstract: The present disclosure includes a nucleic acid purification apparatus and a pipette, the pipette comprises: a tubular body, at least a gas seal ring, a nut, and a shaft. A first opening and second opening arranged at two ends of the tubular body air communicable with the tubular body, thus forming a main chamber. The gas seal ring is disposed in a seal slot arranged proximate to the second opening. The nut is coupled to the second opening and has portions forming a cavity air communicable with the nut and second opening. An opening has a pressing edge. The shaft can movably dispose in the tubular body and the nut. The pressing edge presses against the gas seal ring via the firm coupling of the nut onto the second opening. As a result, individual adjustment can provide the optimum airtightness in nucleic acid purification devices.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 5, 2015
    Applicant: OME TECHNOLOGY CO., LTD.
    Inventor: SHIH-HUNG DING
  • Patent number: 8940232
    Abstract: An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run: Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 27, 2015
    Assignee: ProteinSimple
    Inventors: David J. Roach, Tom W. Yang, Roger A. O'Neill, Robert T. Loder, Jr.
  • Patent number: 8936755
    Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: January 20, 2015
    Assignee: OptiScan Biomedical Corporation
    Inventors: Jennifer H. Gable, James R. Braig, Kenneth I. Li, Mark Wechsler, Peng Zheng, Richard Keenan