Abstract: The invention relates to a device for mounting pipette tips with a coupling element (4) that extends in an axial direction of the longitudinal axis (6). The coupling element (4) features a free end (8) from which a pipette tip (10) is deferrable to the coupling element (4) in an axial direction. Furthermore, the coupling element (4) features a gasket (21), at least one guiding element (25, 26), and a holding element (27). The gasket (21) consists of a flexible material which comprises an exposed sealing section (23) in an axial direction towards the free end (8) of the coupling element (4) against which a sealing section (43) of the pipette tip (10) can press axially. The guiding element (25, 26) is located on the outer side of the coupling element (4) and has the purpose of aligning the pipette tip. The holding element (27) is also located on the outer side of the coupling element (4) for interacting with holding agents (47) of the pipette tip (10).

Abstract: A system and method is described for Automated Visual Pipetting on a machine such as a three dimensional fabrication device like a 3D Printer or other computer numerical control (CNC) machine tools, for improved speed, accuracy and reliability in pipetting procedures. A camera is mounted on a pipette or another type of tool that may be a deposition or non-deposition tool (e.g., milling). A camera feed and recognition software can enable users to replace existing micro-pipetting techniques with a computerized process that may be controlled with a few simple mouse clicks, while the user can directly visualize a live experimental setup. The embodiment also allows for integration with common molecular biology procedure “kits,” and enables the process to be automated and visualized without requiring constant interaction by the user.

Abstract: A disposable pipette tip having that is configured to mount on a tip mounting shaft having a locking section and a separate sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. The collar flexes out of round when it is mounted over the locking lobes on the mounting shaft. The circumferential shelf on the tip isolates the tip barrel from distortion to enable robust sealing in the barrel below the shelf.

Abstract: Provided herein are anti-static pipette trays that reduce the amount of static charge accumulated on or in pipette tips and allow for discharge of any accumulated static charge.

Abstract: The present invention relates to a filtration method, a filter-incorporated tip and a filtration device, and its object is to perform efficient and swift isolation of a target substance.

Abstract: A method of pipetting comprises (a) providing a pipette tip holder having a plurality of segregated compartments and a tip support member for supporting a plurality of pipette tips in the pipette tip holder, the tip support member configured to support a single pipette in tip each segregated compartment; (b providing a plurality of pipette tips in the tip support member; (c) removing a first pipette tip from a first segregated compartment; (d) using the first pipette tip to complete a pipetting operation and placing the first pipette tip into a segregated compartment that has not contained a used pipette tip; (e) subsequently removing the first pipette tip from the segregated compartment and using the first pipette tip to complete another pipetting operation; and, (f) replacing the first pipette tip into the pipette tip holder, whereby the first pipette tip, when placed in the segregated compartment, is segregated in the pipette tip holder to reduce the possibility of a fluid from the first pipette tip contac

Abstract: Gripping tool for automatic laboratory machines, with gripping appliances for gripping vessels, an appliance for converting and/or transferring of movements, the power take-off of which is coupled with the gripping appliances in order to drive them, a coupling appliance for detachable connection with a drive appliance of a tool support of an automatic laboratory machine, which is coupled with the drive of the appliance for converting and/or transferring in order to drive it, and a mounting appliance for detachable mounting of the gripping tool on the tool support of the automatic laboratory machine, while the coupling appliance is connected with the drive appliance of the tool support.

Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.

Abstract: A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

Abstract: A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

Abstract: The present invention is to present a liquid dispensing apparatus which is capable of preventing contamination by previously aspirated liquid, even when residual liquid in a pipette tip separated from the dispensing apparatus is scattered. The liquid dispensing apparatus includes: sample dispensing arm 5 which comprises a dispensing nozzle 54b for aspirating and discharging sample on which a pipette tip 200 is attached; tip separating section 140 for separating the pipette tip 200 from the dispensing nozzle 54b; and nozzle wiping section 16 for cleaning a tip of the dispensing nozzle 54b.

Abstract: The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.

Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter. An improved pipette tip that includes the addition of an elastomeric material and cooperative means for insuring uniform interference and depth of penetration of the pipetter barrel as successive barrels are inserted and ejected. Also disclosed is an improved multiple-tip configuration with similar features that can be mounted to multiple barrels of a multi-pipetter as one tip instead of 8 or 12 individual tips. The addition of the elastomeric material allows for better sealing and eliminates alignment issues, high installation and ejection requirements while reducing the hand and thumb forces that due to repeated use will sometimes result in repetitive stress injury.

Abstract: A drop-in nozzle system for use with a multi-well or multi-column synthesizer or other element distribution system. The drop-in nozzle system includes one or more insertable/removable and/or disposable nozzle inserts, a nozzle housing, an input tube and a fitting. The one or more nozzle inserts are able to vary in length and have ferrule assembly positioned at the top of the insert. As a result, the system enables a user to disconnect a fitting from a nozzle housing cavity thereby releasing the system's liquid-tight seal, replace the current nozzle insert with another insert, and then reconnect the fitting recreating the liquid-tight seal and enabling the system for operation with the new nozzle insert.

Abstract: Magnetic handling structure comprising a retractable magnet and a probe for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

Abstract: A blood glucose meter having a compact housing, a display unit disposed on the housing, the display unit including a display light source to illuminate the display unit, an input unit disposed on the housing, the input unit configured to provide input functions for the blood glucose meter, and a power source provided within the housing for providing power to the blood glucose meter, where the housing includes a port integrated on said housing configured to receive a blood glucose test strip, and corresponding methods of measuring blood glucose meter is provided.

Abstract: A device for automatically aspirating and/or dispensing liquids with precision, comprising a housing having an opening at a lower end with a fixed tip protruding out of the lower end; an interchangeable cartridge disposed inside the housing, the cartridge having a holding frame and a spool of tubing provided in the frame such that one end of the tubing is aligned with the tip; and an actuator enabled to automatically extrude part of the tubing so as to accommodate a preselected volume of liquid, aspirate and/or dispense the liquid through the extruded tubing, and disconnect the extruded tubing from the device.

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter thus reducing the injuries resulting in repetitive stress injury to the thumb and hand. The new ergonomic pipette tip incorporates a separate sealing member constructed from an elastomer that is coupled to the more rigid and chemically inert elongated tubular member that becomes the receptacle for transferring the fluid sample aspirated by the pipetter. The new elastomeric sealing member allows for greater sealing capability or squeeze between the pipetter barrel and the new pipette tip while lowering the coefficient of friction between the mating parts, thus decreasing the axial ejection forces require to overcome the breakaway friction between the new ergonomic pipette tip and the pipetter.

Abstract: A liquid handling system that is configured to receive an interchangeable pipetting head that is selected from a plurality of interchangeable pipetting heads for automated liquid handling flexibility and scalability. The system includes a housing and at least one pipetting head disposed within that housing for aspirating and dispensing a liquid. A locking mechanism interchangeably receives the at least one pipetting head and includes an adaptor plate and a support block. The adaptor plate is operably coupled to the housing and the support block is operably coupled to the at least one pipetting head. The support block is then, in turn, is configured to be operably coupled to the adaptor plate.

Abstract: An air displacement pipette has a tubular pipette tip with an upper section surrounding a locking chamber, and a body section leading from the upper section and tapering downwardly to a reduced diameter end. A tubular mounting shaft on the pipette has a distal end configured and dimensioned for axial insertion into the locking chamber of the pipette tip. Coacting surfaces on the distal end of the mounting shaft and the upper section of the pipette tip establish an axially interengaged relationship between the pipette tip and the mounting shaft in response to insertion of the distal end of the mounting shaft into the locking chamber. A sleeve is axially shiftable on the mounting shaft between a retracted position accommodating the establishment of the axially interengaged relationship, and an advanced position disrupting the axially interengaged relationship to thereby accommodate axial ejection of the pipette tip from the mounting shaft.

Abstract: Mechanisms are provided for automatically removing tips from a pipette nozzle and/or for detecting the type of tip mounted to the nozzle. For detipping, mechanical energy is stored when the tip is mounted to the nozzle and is released when the tip is to be removed to facilitate removal thereof. A mechanism is preferably provided which limits the force with which the tip is mounted to the nozzle and an overforce mechanism may be provided to facilitate removal of a stuck tip. For detecting tip type, each tip type has a different base configuration which results in a different relative displacement between the nozzle and a surrounding component as a result of the tip contacting both during tip mounting, the difference in relative displacement being detected to identify tip type.

Abstract: The invention provides hand-held pipettor in accordance with an embodiment that includes a piston that is received in one end of a cylinder, a pipettor tip that is removably secured to an opposite end of said cylinder, a manually driven unit that reciprocates the piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from the pipettor tip, a mechanism including a stepper motor responsive to control signals for adjusting a range of the stroke, and a voice recognition system that decodes verbal commands and outputs the result to a central processing unit, which in turn generates the control signals.

Abstract: A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

Abstract: A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

Abstract: A pipetting head apparatus includes a pipetting system, and a gripper system, and which includes a floating gripper carriage, which is configured to move independently from said pipetting system. The pipetting system and said gripper system are configured to utilize a common motor. In alternative embodiment, a pipetting head apparatus includes a pipetting system, and a stripper assembly. The pipetting system and the stripper assembly are configured to utilize a common motor. In another alternative embodiment, a pipetting head apparatus includes a pipetting system, which includes a stripper assembly, a main carriage assembly, and a gripper assembly, where the stripper assembly and gripper assembly are both configured to move independently from the main carriage assembly. Also a method is disclosed for distributing material samples for laboratory processing.

Abstract: A system and method for automated handling of vials containing liquid medical specimens is disclosed. The robotic system processes the specimens for further downstream molecular analysis. The processing comprises automated vial cap removal, pipetting of the vial contents, transfer of the vial contents to a destination tray such as a multiwell plate, and recapping of the vial.

Abstract: A fluid-ejection device includes a handheld and/or mountable enclosure, a pneumatic fitting, an electrical connector, and a controller. The pneumatic fitting extends from and/or through the enclosure and is receptive to placement of a tip thereon. The tip contains a supply of fluid, a fluid-ejection mechanism, and an electrical connector for the fluid-ejection mechanism. The electrical connector extends from and/or through the enclosure and is receptive to electrical coupling of the electrical connector of the tip. The controller is situated within the enclosure to cause the tip to eject the fluid via the electrical coupling of the electrical connectors of the tip and the fluid-ejection device.