Tissue Processing Device Patents (Class 422/536)
  • Patent number: 10753836
    Abstract: A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: August 25, 2020
    Assignee: Faxitron Bioptics, LLC
    Inventors: Donogh O'Driscoll, Ciaran Purdy, Kimberly A. Fitzpatrick, Marisa H. Borders
  • Patent number: 10533207
    Abstract: The present invention relates to a novel bioactivity testing structure for single cell tracking using a gelling agent and a bioactivity testing system including the testing structure. The present invention also relates to bioactivity testing, drug susceptibility testing, antibiotic screening, and diagnostic methods using the testing structure. The bioactivity testing structure of the present invention enables very rapid and simple drug susceptibility testing of bacteria, particularly Mycobacterium tuberculosis, drug screening, and bacterial diagnosis. Particularly, the use of the testing structure enables DST and diagnosis of bacteria only by pretreatment without the need to concentrate human sputum samples irrespective of inoculum effect, ensuring rapid, accurate, and simple testing compared to conventional tuberculosis diagnosis or DST systems. In addition, the testing structure of the present invention simultaneously enables the diagnosis and drug susceptibility testing of tuberculosis.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: January 14, 2020
    Assignee: QUANTAMATRIX INC.
    Inventors: Yong-Gyun Jung, Eun Guen Kim, Jung Heon Yoo, Kyung-Ock Park, Sunghoon Kwon, Jungil Choi, Hee jin Kim, Sung Weon Ryoo, Haeun Kim, Hyeon Ju Jeoung, Eun Hee Lee, Hyejin Kim
  • Patent number: 10495654
    Abstract: Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 3, 2019
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Tim Keller, Matthew Mette, Christine Tse, Glen Ward, Chad Wilkinson
  • Patent number: 10197476
    Abstract: An automatic slicing and collecting device, the device including: a first tank, a vibrating microtome, a first pipeline, and a second pipeline. The first tank is filled with a buffer solution. The vibrating microtome is disposed in the first tank. One end of the first pipeline is connected to the vibrating microtome to collect sections, and the other end of the first pipeline is connected to a pump. The pump includes a reversible motor. The first pipeline is provided with a first valve, and a filter is disposed between the pump and the first pipeline. One end of the second pipeline is disposed between the first valve of the first pipeline and the pump, and the second pipeline is provided with a second valve.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 5, 2019
    Assignee: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Hui Gong, Jing Yuan, Tao Jiang, Lei Deng, Qingming Luo
  • Patent number: 10156502
    Abstract: The present invention addresses a problem of providing a tissue piece treating method and a tissue piece treating apparatus by which treatment of a tissue piece by each of liquid chemicals can be favorably performed and a running cost can be reduced.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: December 18, 2018
    Assignees: SAKURA SEIKI CO., LTD., SAKURA FINETEK JAPAN CO., LTD.
    Inventor: Atsuo Ito
  • Patent number: 10100286
    Abstract: Various implementations include systems and methods for automatically and continuously dissociating spheres of cells. In particular, one such system includes a peristaltic pump in fluid communication via tubing with a bioreactor in which cells are cultivated. A plurality of conduits are disposed within a portion of the tubing such that fluid flowing between the bioreactor and the pump passes through the conduits. The conduits have an inner diameter that is sized to provide a shear stress to the fluid of between about 5 to about 60 dynes/cm2, which is sufficient for dissociating the spheres of cells passing through the conduits. For example, each conduit may have an inner diameter of between about 50 and about 250 micrometers.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: October 16, 2018
    Assignee: The Board of Trustees of The University of Alabama
    Inventors: Yonghyun Kim, David A. Dozier, Ursula L. Triantafillu
  • Patent number: 10073017
    Abstract: A tissue specimen handling device comprising a tissue processing cassette.
    Type: Grant
    Filed: November 15, 2015
    Date of Patent: September 11, 2018
    Assignee: PATH TECH, LLC
    Inventors: Wayne Thomas Holland, Rexford Charles Johnson
  • Patent number: 10048175
    Abstract: A biopsy processing system designed to prevent lodging and possible loss of the tissue specimen for analysis. The system includes a biopsy container having a longitudinal wall forming an internal compartment, a biopsy bag attached to an inner surface of the container, a cassette for receiving the biopsy bag, and an automated system for removing the biopsy bag from the biopsy container and placing the biopsy bag in the cassette.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: August 14, 2018
    Assignee: BioVentures, LLC
    Inventors: Shree G. Sharma, Manisha Singh
  • Patent number: 10048174
    Abstract: An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: August 14, 2018
    Assignee: Abbott Laboratories
    Inventors: John Scott Shoffner, Koshy T. Chacko, Roei Solomon
  • Patent number: 9891209
    Abstract: A platelet impedance measurement system including an electrode assembly allows for measurement of platelet function in blood. The assembly includes a substrate that acts as a substantially rigid base and includes an electrode. A portion of the electrode is exposed such that, when the electrode is placed in blood, the exposed portion is in contact with the blood for measuring impedance changes as platelets adhere to the electrode. Wires of the electrode can be attached to each end of the substrate and can run within a groove along a portion of the substrate. The substrate includes an open area where the wires in the groove exit and re-enter the substrate at the end of the substrate, allowing the wires to be exposed to the blood. The open area includes a brace, ensuring that the exposed wires are held in the appropriate placement relative to each other and to the cuvette.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 13, 2018
    Assignee: C A Casyso GmbH
    Inventors: Robert Hillman, Michael M. Gorin, Cory Lee McCluskey
  • Patent number: 9851349
    Abstract: A custom-made matrix suitable for receiving a tissue sample is described, as well as the use thereof to obtain a multiplex histological preparation. The disclosure also relates to a multiplex biopsy array comprising tissue and/or cell samples arranged in a matrix material and to a method for the preparation of a multiplex biopsy array. Methods for preparing blocks of matrix material to be used in multiplex biopsy arrays are also described, as well as methods for loading biopsy samples in the blocks, and methods for treating and processing the blocks to form biopsy arrays. The biopsy arrays made using the block of matrix material can be used to prepare sections and slides for histological procedures, including quantitative analyzes and parallel processing.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: December 26, 2017
    Assignee: Leavitt Medical, Inc.
    Inventor: Sorin Musat
  • Patent number: 9671322
    Abstract: An automated embedding machine includes at least a conveyor, a pouring station, and a cooling station. The conveyor is embodied and arranged to receive casting molds each having at least one histological sample arranged therein, and to transport them to the pouring station which fills each casting mold with an embedding medium heated to above its melting point, and then to the cooling station which cools the embedding medium of each casting mold to below its melting point. The disclosure furthermore relates to a method for embedding a histological sample.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: June 6, 2017
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Markus Berberich
  • Patent number: 9568402
    Abstract: The disclosure relates to a processor for processing histological samples. The processor comprises an inlet for insertion of a closed fixing container having the samples present therein.
    Type: Grant
    Filed: December 22, 2013
    Date of Patent: February 14, 2017
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Ralf Eckert, Markus Berberich, Hermann Ulbrich
  • Patent number: 9468895
    Abstract: This document describes an advanced laboratory platform rocker. An electronic circuit controls the rotation of the shaft of a motor. The shaft is coupled to the platform, such that the angular position of the platform is controllable, as a function of time, enabling non-periodic and non-steady motion. The rotation of the platform can be used to perform other functions, such as initiating the dispensing of liquid into a tray on the platform, and dispersing of liquid from a tray on the platform.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: October 18, 2016
    Assignee: Forward Biotech, Inc.
    Inventors: Brendan Hart, David Grinnell, Ian Glasgow
  • Patent number: 9388945
    Abstract: System, including apparatus and methods, for aspirating at least a portion of an emulsion from a well using a tip. In some embodiments, the tip may have a flat end and an inlet surrounded by the flat end. The well may have a floor with one or more surface features that prevent uninterrupted circumferential contact of the flat end of the tip with any region of the floor. In some embodiments, the tip may not have a flat end. In some embodiments, the well may have a port that guides the tip to the floor with the tip slanted with respect to the floor. Methods of making a device that includes the well are also disclosed.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 12, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Adam Bemis, Thomas H. Cauley, III, Klint Rose, James M. Hamilton
  • Patent number: 9320500
    Abstract: The present invention relates to a kit for taking biopsies, resections, excisions, and/or autopsies. Moreover, the present invention relates to methods of taking biopsies resections, excisions, and/or autopsies using the kit of the present invention. The kits and methods of the present invention allow for fewer errors, decreased turn around time and/or more rapid processing due to a cassette and specimen numbering system that is simplified and superior over that which has been previously disclosed in the prior art. The kit of the present invention comprises one or more tissue cassettes, and optionally one or more bottles of formalin and optionally, other components.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 26, 2016
    Assignee: METAMARK LABORATORIES, INC.
    Inventors: David L. Booker, Stephen Mark Repko, Kimberly A. Grice
  • Patent number: 9267101
    Abstract: A cell culture device allows co-cultivation on both sides of a membrane and has an outer tubular body with upper end having an opening and lower end closed by the membrane, an inner surface and an outer surface, which can be colonized with biological material, a complementary tubular body whose inner diameter fits onto the outer diameter of the lower end and a hanger component with upper end and a lower end. A flange extends from the upper end and the outer diameter component fits the inner diameter of the outer tubular body. The outer tubular body in a first step is connected to the complementary tubular body to form a standing insert for a first cell cultivation, and in a second step wherein the outer tubular body is disengaged from the complementary tubular body and is attached to the hanger component for a second cell cultivation.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: February 23, 2016
    Assignee: NATURIN VISCOFAN GMBH
    Inventors: Timo Schmidt, Lothar Just, Holger Becker
  • Patent number: 9121796
    Abstract: The invention relates to a method for execution upon processing of at least one histological sample that is arranged, in particular after an infiltration process, in a closed cassette (2). The method is characterized in that prior to opening of the cassette (2), the sample is detached from the cover of the cassette (2) and/or isolated.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 1, 2015
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Arne Burisch, Christian Löchte, Annika Raatz, Hermann Ulbrich, Karl-Heinrich Westerhoff
  • Patent number: 9034278
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: May 19, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Johnway Gao
  • Patent number: 9028779
    Abstract: The device for the transfer of a medium comprises a magazine (2) and at least one transfer element (3) for transfer of said medium, said transfer element (3) comprising a duct (45) for transfer of said medium provided at one end with a needle (31), a septum (32), and a maneuvering unit (33) of said needle (31), said transfer element (3) also comprising means for locking (61, 65) adapted to cooperate with complementary locking means (15) of said magazine (2) to lock said needle (31) in a waiting position, said locking means (61, 62, 65) belonging to said maneuvering unit (33) and cooperating with said complementary locking means (15) at a location of said magazine (2) distinct from the location through which said duct (45) issues from the cavity (20), at the opposite end from the needle (31).
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 12, 2015
    Assignee: EMD Millipore Corporation
    Inventor: Stephane Olivier
  • Patent number: 9028778
    Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Abbott Laboratories
    Inventors: Abe S. Mamaghani, Koshy T. Chacko, Rupa Rao, Rene Nieves
  • Patent number: 9023294
    Abstract: Provided is a cell concentration and purification device, having: a function of continuously concentrating cells; a function of then subsequently disposing the cells continuously in a specific region of a channel; a function of simultaneously recognizing, based on an image, the shape and fluorescence emission of each single cell; and a function of recognizing the cells and then separating and purifying the same based on the data relating to the shape and fluorescence emission thereof.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 5, 2015
    Assignees: Kanagawa Academy of Science and Technology, National University Corporation Tokyo Medical and Dental University, On-Chip Cellonics Consortium Co., Ltd.
    Inventors: Hideyuki Terazono, Kenji Yasuda, Masahito Hayashi, Hiroyuki Takei, Akihiro Hattori
  • Publication number: 20150111202
    Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: Xuan S. Bui, Anthony L. Hartman, Toshiyuki Fujimaki, Shinji Tokudaiji, Yoshitake Okabe, Yoshitada Mizusawa
  • Patent number: 9011773
    Abstract: An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 21, 2015
    Assignee: Abbott Laboratories
    Inventors: John Scott Shoffner, Koshy T. Chacko, Roei Solomon
  • Patent number: 8999269
    Abstract: The present invention relates to a glass plate (2) for use in a device (1) for stretching sample sections having a sectioning knife, the glass plate (2) being arranged at the back (3) of the sectioning knife in such a way that a defined gap (4) for reception of the sectioned sample is formed between the back (3) of the sectioning knife and the plate (2), the glass plate (2) possessing, at least on one of its longitudinal sides (21, 22), edges (211, 212; 221, 222) ground and polished to optical flatness.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: April 7, 2015
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Ralf Unger, Frank Eisenkrämer
  • Patent number: 8999270
    Abstract: An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: April 7, 2015
    Assignee: BioPath Automation, L.L.C.
    Inventors: Warren P. Williamson, IV, Stephen P. Whitlatch
  • Patent number: 8992863
    Abstract: A tissue processing system includes a plurality of processing stations. Each processing station includes a plurality of tissue receiving areas that are each configured to accommodate a tissue sample as well as physically isolate that tissue sample from other tissue samples at other receiving areas of the same processing station. Each processing station is configured to separately and individually process the tissue sample at each receiving area to either reduce or eliminate any potential for cross-contamination between the tissue samples undergoing processing at the same processing station. For each receiving area of each processing station, the system is configured to immerse a tissue sample at a particular receiving area in processing fluid for a pre-determined time according to a pre-defined protocol that is based upon parameters of that tissue sample.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: March 31, 2015
    Assignee: Rushabh Instruments, Inc.
    Inventor: Preyas Shah
  • Publication number: 20150087018
    Abstract: A histology processing cassette comprising a box comprising a compartment for holding a biological tissue sample, the box having a bottom face comprising at least in part a sample support surface and being transmissible to radiation, an open top face, and two side walls, a back wall and a front wall, the box having dimensions greater than a standard size histology processing cassette and comprising a recess in the front wall adapted to receive a standard size cassette which has a front wall comprising a unique identifier for the biological tissue sample such that upon insertion of the standard cassette in the recess the unique identifier on the front wall of the standard cassette is readable.
    Type: Application
    Filed: September 23, 2014
    Publication date: March 26, 2015
    Inventors: Paul Webber, Philip Webber, Richard Titcombe
  • Publication number: 20150087019
    Abstract: A method of avoiding deformation and providing for a more consistent thickness of a biological tissue sample during preparation for analysis comprising providing a histology processing cassette comprising a box defining a compartment for holding a biological tissue sample, the box having a bottom face comprising a sample support surface and being transmissible to radiation or a flow of fluid through to pass through the cassette, an open top face, and two side walls, a back wall and a front wall, the box having a length and width greater than a standard size histology processing cassette and a depth approximately the same as a standard size histology processing cassette placing the sample in the cassette and treating the sample by contacting it with a processing solution; and contacting the sample with molten paraffin wax and cooling the sample in molten paraffin wax so the sample is embedded in solidified paraffin wax for further processing.
    Type: Application
    Filed: September 23, 2014
    Publication date: March 26, 2015
    Inventors: Paul Webber, Philip Webber, Richard Titcombe
  • Publication number: 20150079592
    Abstract: A method and an automated apparatus for processing at least one biological sample arranged on a slide. At least one capillary staining module has a slide rack holder configured to detachably hold a slide rack configured to hold slides, and a capillary lid rack holder configured to detachably hold a capillary lid rack configured to hold capillary lids, wherein the slide rack can be removed independently of removing the capillary lid rack. A first fluid container has a first fluid. The apparatus being configured to automatically rotate the one or more slides, and to move the lids towards the slides to automatically form a capillary gap between each slide and each capillary lid, said capillary gap functioning as a capillary chamber; and to supply an amount of the first fluid to the slide.
    Type: Application
    Filed: October 2, 2014
    Publication date: March 19, 2015
    Applicant: DAKO DENMARK A/S
    Inventors: Søren Damgaard Larsen, Peter Axel Valbjørn
  • Publication number: 20150071832
    Abstract: A cell grabber has a unitary structure including a transparent grabber head at a terminus thereof and an elongated mounting portion extending therefrom for attachment to a force transducer. The grabber head has a planar or concave bonding surface which is coated with an adhesive film to secure the specimen, especially single cells, for tensile measurements. The cell grabber may be used in connection with auxotonic, isometric or isotonic force measurement systems.
    Type: Application
    Filed: September 3, 2014
    Publication date: March 12, 2015
    Inventor: Richard T. Udale
  • Publication number: 20150071833
    Abstract: An apparatus can be used to apply and remove fluid substances for processing biological samples. The fluid substances can be delivered between a first substrate and a second substrate. One substrate carries a specimen. A layer of the fluid substance is retained in a gap defined by the first and second substrates. One substrate is moved with respect to the second substrate to disperse the fluid substance in the gap.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 12, 2015
    Inventors: Brian Howard Kram, Kevin David Marshall, Christine Tse, Timothy James Keller, Austin Micheil Ashby
  • Patent number: 8969075
    Abstract: A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached thereto a filter. The cell flow pathway is in communication with a reagent flow pathway for delivering the reagents through the sample port to the cassette. The apparatus is configured such that the application of pressure directs the cell fragments from the cell sample through the cell flow pathway, and effects delivery of the reagents through the reagent flow pathway.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: March 3, 2015
    Assignee: University of Massachusetts
    Inventor: Andrew H. Fischer
  • Patent number: 8968683
    Abstract: The invention relates to a tissue sample handling apparatus, in particular for grasping histological samples after infiltration of an embedding medium such as, for example, paraffin, which is characterized in that a sample is immobilizable on the handling apparatus, in particular in a sample holding position, by means of negative pressure.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: March 3, 2015
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Arne Burisch, Christian Löchte, Annika Raatz, Hermann Ulbrich, Karl-Heinrich Westerhoff
  • Patent number: 8967024
    Abstract: Apparatuses and methods for handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. The flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: March 3, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
  • Patent number: 8962258
    Abstract: Provided are a multiple immunoassay apparatus on a chip in which a structure comprising multiple microfluidic channels is associated with a tissue sample, which allows immunohistochemical reactions to be conducted therein, to examine various markers specific for certain diseases, and a method for performing multiple immunoassays using the same. The multiple immunoassay apparatus comprises: at least one antibody-introducing unit through which at least one antibody is introduced into the apparatus; at least one reaction unit in which the antibody reacts with a sample in an immunohistochemical pattern; and at least one fluid outlet through which a fluid including the antibody is discharged outside the apparatus.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 24, 2015
    Assignees: Korea Advanced Institute of Science and Technology, National Cancer Center
    Inventors: Je-Kyun Park, MinSeok Kim, Eun Sook Lee, Sun-Young Kong, Solm Kwon
  • Publication number: 20150044664
    Abstract: A temperature control device and method are provided for an analytical system for performing laboratory protocols. The device includes a well within a housing configured to receive a biological specimen according to a predetermined sample process. The specimen is suspended by a holding device in the well. A thermal element is provided in heat exchange communication with fluid in the well. A temperature sensor is located in the well at a location to be covered and uncovered by rocking motion of fluid in the well. A controller, in communication with the thermal element, the temperature sensor, and an agitation system, is operative to control the thermal element in correlation with temperature data, for example, peak temperature data, from the temperature sensor.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 12, 2015
    Inventors: Kevin J. Sullivan, James Kelland, Nhat Khai L. Nguyen
  • Patent number: 8945483
    Abstract: Disclosed are a method for attaching an RFID tag to a memory cassette for tissue specimens and a memory cassette for tissue specimens having the RFID tag attached thereto, in which the RFID tag is attached to the memory cassette for tissue specimens and the RFID tag operates stably even when the memory cassette having the RFID tag attached thereto comes in contact with chemicals or is submerged in various chemical solutions. The method includes forming the memory cassette for tissue specimens provided on an inclined plane of a front surface of a body with an RFID tag insertion groove, inserting the RFID tag into the RFID tag insertion groove provided on the inclined plane of the body, and attaching a protective cap onto the top of the inclined plane of the body in which the RFID tag is inserted into the RFID tag insertion groove, and coupling the protective cap to the inclined plane of the body by ultrasonic welding to adhere the RFID tag to the body of the memory cassette for tissue specimens.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 3, 2015
    Assignee: Time System Co., Ltd.
    Inventors: Byung Gyu Park, Yong Pill Kim, Kwang Il Choi
  • Patent number: 8945482
    Abstract: The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). In addition, the current invention provides specific compositions of the said liquefaction promoting medium so as to facilitate liquefaction, preserve liquefied tissue constituents, and enable delivery of molecules into tissues.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: February 3, 2015
    Assignee: The Regents of the University of California
    Inventors: Samir Mitragotri, Sumit Paliwal, Makoto Ogura
  • Publication number: 20150023848
    Abstract: A biopsy processing system designed to prevent lodging and possible loss of the tissue specimen for analysis. The system includes a biopsy container having a longitudinal wall forming an internal compartment, a biopsy bag attached to an inner surface of the container, a cassette for receiving the biopsy bag, and an automated system for removing the biopsy bag from the biopsy container and placing the biopsy bag in the cassette.
    Type: Application
    Filed: October 8, 2014
    Publication date: January 22, 2015
    Inventors: Shree G. Sharma, Manisha Singh
  • Publication number: 20150024425
    Abstract: In one embodiment, an apparatus for forming wounds in cell layers includes a base that includes a guide track, and a sliding member adapted to fit within the guide track, the sliding member including a scratching element holder adapted to secure a scratching element in a position in which it contacts a cell layer, wherein the sliding member is further adapted to slide along the guide track to drag the scratching element through the cell layer.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventors: John S. Bergmann, Celeste C. Finnerty, David N. Herndon
  • Patent number: 8932539
    Abstract: Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Pathway Genomics Corporation
    Inventors: James Plante, David Becker, Edgar MacBean, Kathryn J. Elliott
  • Publication number: 20150005190
    Abstract: A biological and chemical sample processing device that b. comprises a high pressure-resistant, shallow and wide area microfluidic chamber having at least one wall formed by a detachable slide containing samples such as immobilized entities, biological samples or molecules, c. comprises an arrangement of microfluidic access holes for injecting to and collecting fluid form said chamber, d. is interfaced with inlet ports and microfluidic channels which are formed external to the chamber, e. is configured so that the slide may be brought into contact with the device to form the said chamber, f. is adapted to deliver and to transport fluidic substances and reagents inside said chamber in a fast manner, preferably within less than 15 seconds, and in a regular or uniform way owing to said arrangement of microfluidic access holes.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 1, 2015
    Inventors: Ata Tuna Ciftlik, Martin Gijs
  • Patent number: 8920720
    Abstract: A configurable tissue processing system is disclosed that includes a plurality of configurable tissue processing stations, each station configured to receive tissue samples and selectively configurable to heat, agitate and apply either a positive pressure or a vacuum pressure to the received tissue samples; a transport mechanism that is configured to transport the tissue samples between the plurality of configurable tissue processing stations; and a control unit coupled to the plurality of configurable tissue processing stations and to the transport mechanism, the control unit controlling the transport mechanism to selectively position the tissue samples in the plurality of configurable tissue processing stations, and the control unit configuring each of the plurality of configurable tissue processing stations to heat, agitate and apply either a positive pressure or a vacuum pressure to the received samples. Also disclosed is a method of configuring the plurality of tissue processing stations.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: December 30, 2014
    Assignee: Rushabh Instruments, Inc.
    Inventor: Preyas Shah
  • Publication number: 20140377148
    Abstract: A tissue handling device is disclosed. A tissue collecting device is disclosed. A cassette for handling biological tissues is disclosed. A tissue dyeing device is disclosed. A method for handling biological tissues is disclosed. A method for dyeing biological tissues is disclosed.
    Type: Application
    Filed: January 10, 2013
    Publication date: December 25, 2014
    Inventors: Alex Pasternak, Keren Shapira-Schweizer, Shaike Schatzberger
  • Patent number: 8911680
    Abstract: The invention relates to a system for collecting a biological sample comprising a container having at least one open end, a closure fitting on or in said at least one open end, a holding element connected to said closure and a solid matrix on which said biological sample is deposited, and optionally at least one processing agent, wherein said solid matrix is at least partially transferable into a liquid or dissolved state by changing at least one physico-chemical property of the environment of said matrix without disintegration of the biomolecules comprised in said biological sample deposited on said matrix.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 16, 2014
    Assignee: Preanalytix GmbH
    Inventors: Thomas Hanselle, Markus Sprenger-Haussels, Christian Lenz, Daniel Groelz, Uwe Oelmueller
  • Publication number: 20140356941
    Abstract: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening in the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path. The seal may be configured to temporarily obstruct flow through at least a portion of the flow path. The seal may also be configured to open in response to a force exerted via a capillary tube inserted into the at least one opening.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Inventors: Avishay Bransky, Liron Shiomo
  • Publication number: 20140348725
    Abstract: An apparatus (10) for handling specimen slides comprises a first module receiving region (18) in which a coverslipping module (100, 200), for coverslipping thin sections arranged on the specimen slides with a coverslipping medium and a coverslipping element, is receivable. A first electrical interface is provided in the first module receiving region (18) for attachment of a coverslipping module (100, 200), this interface being embodied so that by way of it, both a glass coverslipping module (100) for coverslipping with glass wafers and a tape coverslipping module (200) for coverslipping with tapes is attachable. The first module receiving region (18) is furthermore embodied in such a way that a tape coverslipping module (200) or a glass coverslipping module (100) is selectably receivable in it.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 27, 2014
    Applicant: Leica Biosystems Nussloch GmbH
    Inventor: Markus Berberich
  • Patent number: 8883509
    Abstract: An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: November 11, 2014
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Charles D. Lemme, William Richards, Glen Ward, Austin Ashby, Andrew Ghusson, Lisa Jensen-Long, Kevin Knapp, Rodney Kugizaki, Alain Larson, Paul Richards, Wayne Showalter, Chad Wilkinson
  • Patent number: 8871159
    Abstract: This invention provides compositions and methods useful for the processing of a tissue sample and the preparation of cells, cell aggregates and/or tissue fragments. The invention provides two-stage filer devices and two-membrane devices. Cell aggregates and/or tissue fragments prepared using such devices and according to methods of the present invention can be used in a variety of assay systems, including, but not limited to, drug validation assays, drug screening assays, proliferation assays, metabolic assays, metastasis assays, angiogenesis assays, binding assays, biochemical assays, cellular assays, genetic assays, and the like.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: October 28, 2014
    Inventor: Christian Apfel