Including Connector Patents (Class 422/538)
  • Patent number: 12000765
    Abstract: A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: June 4, 2024
    Assignee: Ventana Medic Systems, Inc.
    Inventors: Nathan Crum, Michael Otter
  • Patent number: 12000763
    Abstract: A disposable blood sampler for a blood braid of a blood bag includes a blood taking needle cannula, a threaded cannula, a blood braid clamp, a connecting pipe, a needle inserting sheet and a blood braid. The blood taking needle cannula includes a tubular threaded structure at both ends, a bottom port of the threaded cannula is connected with the blood taking needle cannula, and an upper port of the threaded cannula includes symmetrically distributed clamping slots extending to a middle lower part of the wall. Grips are arranged on the outer wall surface of the blood braid clamp, and the blood braid clamp is arranged in the threaded cannula. The grip is arranged outside the clamping slot, and the connecting pipe is directly inserted into the upper port. An inner cavity in which the needle inserting sheet is placed is arranged inside the inner part of the connecting pipe.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: June 4, 2024
    Assignee: TAIZHOU PEOPLE'S HOSPITAL
    Inventors: Lingbao Gao, Yayun Sha, Ziang Gao
  • Patent number: 9546395
    Abstract: Systems and methods for monitoring biofilm growth are provided. A method comprises supporting at least one coupon in a water reservoir, wherein the water reservoir feeds water into a tower interior, removing the at least one coupon from the water reservoir, and measuring a level of biofilm growth on the at least one coupon. The level of biofilm growth on the at least one coupon is predictive of a level of biofilm growth within the tower interior. Providing an indicator of predictive biofilm growth may allow measures to be taken to prevent biofilm growth in other sectors or areas of the tower.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 17, 2017
    Assignees: ROHM AND HAAS COMPANY, DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Peter Jasko, III, Robert Marquard, Christine Mcinnis
  • Patent number: 9011801
    Abstract: The invention provides for fluidic connections to be established between tubes, ports, fluidic components and fluidic devices. The leak-tight connections are formed through controlled, compressive forces and can be used for both low and high pressure applications.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: April 21, 2015
    Assignee: Corsolutions LLC
    Inventors: Thomas N. Corso, Colleen K. Van Pelt
  • Patent number: 8840852
    Abstract: The invention relates to a sampling valve, for taking samples of fluid from a common collecting vessel in order to perform a plurality of analyses using reagents. The valve of the invention comprises two members that are movable relative to each other, comprising a sampling member having sampling loops, each intended to receiving an aliquot of fluid, and a connection member capable of assuming at least three functional positions relative to the sampling member. These three positions enable the delayed access to two separate sampling circuits in order to fill them and to dispense reagents to the loops that make them up.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: September 23, 2014
    Assignee: Horiba ABX SAS
    Inventor: Olivier Bouchentouf
  • Patent number: 8821814
    Abstract: A microfluidic device including a platform and a cartridge is disclosed. The platform includes a chamber containing a fluid. The reagent cartridge is mounted to the platform. and contains a solid reagent for detecting material contained in the fluid.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: September 2, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yoonkyoung Cho, Dogyoon Kim, Beomseok Lee, Jongmyeon Park, Hyunmin Kim, Yangui Lee, Jong Gun Lee
  • Publication number: 20140206097
    Abstract: An apparatus for providing a sample gas includes a gas dosing part, a first pressure gauge for measuring a pressure of a sample gas dosed through the gas dosing part, a plurality of flow lines positioned between the gas dosing part and a gas analyzer that can be opened or closed according to the pressure measured by the first pressure gauge, a plurality of control valves respectively formed in the plurality of flow lines and controlling the plurality of flow lines to be opened or closed, a bypass line formed on at least one of the plurality of flow lines and exhausting some of the sample gas flowing along the flow lines, and a controller for selecting one of the plurality of flow lines according to the pressure measured by the first pressure gauge and controlling the control valves formed in the selected flow line.
    Type: Application
    Filed: January 6, 2014
    Publication date: July 24, 2014
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: Jong-Cheol Jeong, Kyung-Hwan Jeong, Jong-Soo Kim, Pil-Kwon Jun
  • Patent number: 8758708
    Abstract: It comprises, in addition to a sampling system (3), at the outlet of a vat (1) containing the liquid to be sampled, a selector (4) that establishes switching on an array of similar vats (1), and especially a suction unit (5) that operates by releasing compressed air into a nozzle (28); the airflow direction is controlled by a valve (29) between a direction directed toward the outlet (6), causing the suction of the liquid from the vat (1), and an opposite direction when the valve (29) is closed, feeding the liquid back into the vat (1) and cleaning the pipe (2).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 24, 2014
    Assignee: Commissariat a l'Energie Atomique et aux Enegies Alternatives
    Inventors: Christophe Brenneis, Hervé Lagrave, Jacques Mamert
  • Patent number: 8758687
    Abstract: The present invention is an apparatus and fluid delivery system for automated assays. The apparatus, for example, may be used for western blotting that uses flow lines for multiple reagents. In one embodiment, the present invention comprises a tray base with one or more fixed or disposable trays for testing samples, multiple flow lines, and multiple valves and the system is used for automatic controlled delivery of different fluids from supply vessels to different trays and discharges them to designated reservoirs or sewage system with minimum of operator actions. The system may include air line to assist supply and discharge the fluids and also coupled with measuring vessels with adjustable volume and valves adapted to interface with a valve operating unit with drive means.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: June 24, 2014
    Assignee: Precision Biosystems
    Inventors: Gregory Gorelik, Rus Yukhananov
  • Patent number: 8647591
    Abstract: A microarray reaction device includes a fluid container, a reaction chamber, a first channel connected with the fluid container, a second channel connected with the reaction chamber, and a valve. The valve includes a first and second support unit, respectively including a first and second penetration opening unit, extended through a first and second surface thereof. The first and second penetration opening unit is connected to a second end of the first and second channel, respectively. The second support unit includes a third penetration opening unit extended through a second surface thereof. The first and second surfaces contact each other, such that the first support unit and the second support unit are slidably disposed with each other. The microarray reaction device further includes a storing chamber connected with the third penetration opening unit, and a pump connected to the storing chamber and providing pressure to the storing chamber.
    Type: Grant
    Filed: January 17, 2011
    Date of Patent: February 11, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Won-seok Chung, Myo-yong Lee, Kak Namkoong, Woochang Lee
  • Patent number: 8636964
    Abstract: An end-face sealing fluidic connector for fluidic connection and/or interconnection of glass, glass-ceramic and/or ceramic fluidic modules in a microreactor includes a connector body having a circular first end face with a recess for retaining one or more O-rings and a first end section having a circular cylindrical outeT surface and a diameter In the range of from 3 to 25 mm. The outer surface has a circumferential recess dividing the first end section into a proximal portion adjacent the first end face and a distal portion. A retaining ring is seated in the circumferential recess and a protecting ring coinpming a high-compression-strength polymer surrounds the proximal portion of the first end section. A circular cylindrical sleeve surrounds the first end section and the reinforcing and/or protecting ring, the sleeve including a circumferentially extending inside bearing surface for engaging the retaining ring on the distal side thereof.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: January 28, 2014
    Assignee: Corning Incorporated
    Inventors: Pierre Brunello, Paul Louis Florent Delautre, Sylvain Maxime F Gremetz, Olivier Lobet
  • Patent number: 8585985
    Abstract: An apparatus for staining sample sections, comprising: a chamber that is adapted for fastening sample sections therein; and a pump that is adapted for pumping liquids through the chamber. The chamber has an inlet and an outlet. The inlet can be connected to at least one reservoir of a staining liquid via inlet lines that are controllable by valves. The inlet lines are formed at least in the region of the associated valves by means of elastic hose lines, and the valves are formed as hose pinch valves. This apparatus minimizes or eliminates contaminations arising from staining processes for thin sections that are in particular prepared for examination in an electron microscope.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: November 19, 2013
    Assignee: Leica Mikrosysteme GmbH
    Inventors: Reinhard Lihl, Heinz Plank, Siegfried Tanki
  • Publication number: 20130142709
    Abstract: The present disclosure relates to a calibration cartridge for an in vitro medical diagnostic device. The device also includes a removable assay cartridge containing a polymer body with channels for fluid movement.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 6, 2013
    Applicant: Edan Diagnostics
    Inventor: Edan Diagnostics
  • Patent number: 8425863
    Abstract: A micro fluidic device includes a valve/pump-unit with reduced dead volume having a substrate. The lower surface of the substrate includes two micro channels spaced apart by a valve area of the substrate that separates the two micro channels. A flexible membrane is arranged on the lower surface of the substrate facing an actuating element located in a through going cut-out of a cover element. Movement of the actuating element towards and away from the valve area of the substrate causes a pump and/or valve action of the flexible membrane area, respectively, to cause or stop a directed fluid flow between the two micro channels through a channel formed between the valve area of the substrate and the flexible membrane.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: April 23, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Chris Van Haag, Ronald Cornelis De Gier, Adrianus Wilhelmus Dionisius Maria Van Den Brijgaart, Gheorghe Sorin Stan
  • Patent number: 8398938
    Abstract: A microfluidic thermal bend actuated pressure pulse valve having an inlet for receiving a flow of liquid, an outlet for outputting the flow of liquid, a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, a movable member for contacting the liquid, and, a thermal expansion actuator for displacing the movable member to generate a pulse in the liquid to dislodge the meniscus such that the liquid flow towards the outlet resumes.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 19, 2013
    Assignee: Geneasys Pty Ltd
    Inventors: Mehdi Azimi, Matthew Taylor Worsman, Kia Silverbrook
  • Patent number: 8372357
    Abstract: A rotatable microfluidic device that comprises a hydrophilic microchannel structure in which there is a) an upstream microcavity I with a liquid outlet I, b) a microconduit I connected to liquid outlet I, and c) a capillary valve I associated with microconduit I. The inlet end of the microconduit is closer to the spin axis than the outlet end of the microconduit. The difference in radial distance between the inlet end and the outlet end of microconduit I is typically ?5%, such as ?10% or ?100% or ?500%, of the difference in radial distance between the uppermost part of the upstream microcavity and liquid outlet I.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: February 12, 2013
    Assignee: Gyros Patent AB
    Inventors: Per Andersson, Gunnar Ekstrand, Gérald Jesson
  • Patent number: 8354074
    Abstract: A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 15, 2013
    Assignee: Geneasys Pty Ltd
    Inventors: Kia Silverbrook, Mehdi Azimi
  • Patent number: 8268252
    Abstract: A unique combination of male and female gas connectors for one way transfer of gasses.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: September 18, 2012
    Assignee: GENO LLC
    Inventors: Jody Fuller, David H. Fine
  • Patent number: 8147773
    Abstract: A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: April 3, 2012
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Charles D. Lemme, Vincent R. Rizzo, Jr., Bobbi Druyor-Sanchez, Anthony Ford, Bronwen Heilman, Darin McDaniel, Brian McGraw, Stephen Mead, William Richards, Wayne Showalter
  • Publication number: 20120053088
    Abstract: A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus.
    Type: Application
    Filed: June 1, 2011
    Publication date: March 1, 2012
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Patent number: 8124024
    Abstract: A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: February 28, 2012
    Assignee: GenturaDx, Inc.
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 8071057
    Abstract: A microfluidic valve device includes a microfluidic chip including a substrate having a channel, a valve disposed within the channel and configured to change a conductance of the channel, with the valve having an inner channel formed therein, and an oscillator configured to generate a traveling wave. The valve is moved by generating the traveling wave to open and close the channel.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: December 6, 2011
    Assignee: Canon Kabushiki Kaisha
    Inventors: Toshinobu Tokita, Kosuke Fujimoto
  • Publication number: 20110281373
    Abstract: The invention relates to a sampling valve, for taking samples of fluid from a common collecting vessel in order to perform a plurality of analyses using reagents. The valve of the invention comprises two members that are movable relative to each other, comprising a sampling member having sampling loops, each intended to receiving an aliquot of fluid, and a connection member capable of assuming at least three functional positions relative to the sampling member. These three positions enable the delayed access to two separate sampling circuits in order to fill them and to dispense reagents to the loops that make them up.
    Type: Application
    Filed: December 2, 2008
    Publication date: November 17, 2011
    Inventor: Olivier Bouchentouf
  • Patent number: 8057758
    Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: November 15, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: William Bedingham, Barry W. Robole, Ranjani V. Parthasarathy, Katya Ericson
  • Patent number: 8017092
    Abstract: An analyzer enabling the user to hardly breathe in a malodor given off from a reagent when exchanging a reagent container is obtained. This analyzer, connected with a reagent container including a flexible container body storing the reagent, comprises an analyzer body analyzing an analyte with the reagent and reagent transporter having a first end connected to the analyzer body and a second end connected to the reagent container. The reagent transporter includes a first connectional part, detachably connected to the reagent container, having a first switching member forming and blocking a first passage between the analyzer body and the reagent container, while the first switching member blocks the first passage when the first connectional part is separated from the reagent container, and forms the first passage when the first connectional part is connected to the reagent container.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: September 13, 2011
    Assignee: Sysmex Corporation
    Inventor: Karl-Heinz Bindrim
  • Patent number: 7998437
    Abstract: A microfluidic assembly (1;57) has at least one microfluidic flow path (17,27,29,35,38;82,85,95) and at least one inlet port (11,13,15;81,97,101) coupled to the flow path (17,27,29,35,38;82,85,95). The microfluidic assembly (1;57) has a first microfluidic device (7;63) that executes a microfluidic process and has a second microfluidic device (9;61). The microfluidic assembly (1;57) has an interface (5;65). The interface (5;65) couples the first microfluidic device (7;63) and the second microfluidic device (9;61).
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: August 16, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Manfred Berndt, Marcus Gassmann
  • Patent number: 7981386
    Abstract: A mechanically-actuated microfluidic valve. The valve comprises an inlet port; an outlet port; a thermal bend actuator; and a valve closure member cooperating with the actuator. Actuation of the thermal bend actuator causes movement of the closure member, thereby regulating a flow of fluid from the inlet port to the outlet port.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: July 19, 2011
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Gregory John McAvoy, Kia Silverbrook
  • Patent number: 7892471
    Abstract: The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: February 22, 2011
    Assignee: Millipore Corporation
    Inventors: Aaron Burke, Joseph William Muldoon