Valve Patents (Class 422/537)
  • Patent number: 10293573
    Abstract: Provided is a method for producing a micro flow channel chip that is used for a treatment or analysis of a liquid sample, the method being capable of producing a micro flow channel chip with high shape accuracy and high efficiency. The method includes a step of forming a groove on one surface of a base material; a lamination step of forming an adhesive resin layer on at least one surface of a resin film, and thereby obtaining a first laminate; and an adhesion step of arranging the surface of the base material where a groove has been formed and the adhesive resin layer of the first laminate to face each other, and bonding the base material and the first laminate such that the adhesive resin layer covers the groove, in which the glass transition temperature of the adhesive resin layer is 25° C. or lower.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 21, 2019
    Assignee: SUMITOMO BAKELITE COMPANY LIMITED
    Inventor: Hirohito Taniguchi
  • Patent number: 10272430
    Abstract: A disposable cartridge and method for measuring one or more properties of a blood sample are provided. The disposable cartridge can receive a sample when it is in an unsealed configuration. After adjusting the cartridge from the unsealed configuration to a sealed configuration, facilitated by a hingedly attached cap, pressurized air from an air bladder may be used to force the blood from a sample storage well into a detection chamber in a regulated manner, so that the one or more properties of the blood sample may then be measured.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: April 30, 2019
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Patent number: 10073088
    Abstract: A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: September 11, 2018
    Assignee: Abon Biopharm (Hangzhou) Co., Ltd
    Inventors: Lin Hu, Haipeng Hu, Yinfei Wu
  • Patent number: 9999884
    Abstract: A disposable cartridge for rapidly metering a sample for measuring a property of the sample is described. The cartridge can receive a sample when it is in an unsealed configuration, and a cap is used to facilitate metering of the sample and sealing the cartridge. When the cartridge is in a sealed configuration, pressurized air is used to push the metered sample into a chamber containing at least one reagent, and subsequently into a detection chamber for measuring a property of the sample.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: June 19, 2018
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Patent number: 9821307
    Abstract: Some embodiments of the invention provide a disposable cartridge for rapidly metering a sample for measuring a property of the sample. The cartridge can receive a sample when it is in an unsealed configuration, and a cap is used to facilitate metering of the sample and sealing the cartridge. When the cartridge is in a sealed configuration, pressurised air is used to push the metered sample into a chamber containing at least one reagent, and subsequently into a detection chamber for measuring the property of the sample.
    Type: Grant
    Filed: November 20, 2016
    Date of Patent: November 21, 2017
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Patent number: 9675503
    Abstract: A body fluid test arrangement for an absorbent article includes a body fluid test device for receiving and examining voided body fluid. The body fluid test arrangement is configured to attach to a topsheet of the absorbent article. The body fluid test arrangement includes a fastening means for attachment to the topsheet of the absorbent article by a peelable connection between the body fluid test arrangement and the topsheet. The fastening means provides an attachment of the body fluid test arrangement having a peel strength from 0.05 to 1.65 (N×cm)/cm2. An absorbent article including a body fluid test arrangement also is provided.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: June 13, 2017
    Assignee: SCA Hygiene Products AB
    Inventor: Joshua Carney
  • Patent number: 9574976
    Abstract: Embodiments of the invention relate to a device for transporting and preparing cellular material in a fluid for subsequent diagnostic purposes, comprising a cylinder having a fluid-tight screw-on cap and a fluid-tight base part that can be screwed off of the cylinder. The cap can be screwed onto the base part in a fluid-tight matter. The device provides for introducing cellular material to be diagnosed into a fluid in the cylinder, closing the cylinder by a cap for transport, removing the cap, introducing a filter device and concentrating the cellular material on a filter surface, after which the fluid level is at that part of the base part below the connection to the cylinder, disposing of the filtrate, removing the base part, pressing the filter surface onto an object carrier for a cell analysis, and closing the base part by the cap for further transport.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: February 21, 2017
    Inventors: Otto Berners, László Fiac Vass
  • Patent number: 9480462
    Abstract: This invention includes the implementation of several unconventional droplet manipulations on a superhydrophobic-patterned surface microfluidic platform, which may be applied to automated biological analyzes and point-of-care diagnostic applications.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Tingrui Pan, Siyuan Xing
  • Patent number: 9404850
    Abstract: A microscope system includes: a microscope that generates an observation image of a specimen; an image obtaining unit that obtains an RGB image of the specimen; a spectroscopic information obtaining unit that obtains spectroscopic information of the specimen; an analyzer that analyzes the RGB image; a determining unit that determines a necessity of obtaining the spectroscopic information based on a result of the analysis of the analyzer; and a control unit that controls an operation of the spectroscopic information obtaining unit based on a result of the determination of the determining unit.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: August 2, 2016
    Assignee: OLYMPUS CORPORATION
    Inventor: Masanori Mitsui
  • Patent number: 9334528
    Abstract: A system that includes a cartridge housing and a hollow transfer module, according to an embodiment is described herein. The cartridge housing further includes at least one sample inlet, a plurality of storage chambers, a plurality of reaction chambers, and a fluidic network. The fluidic network is designed to connect the at least one sample inlet, a portion of the plurality of storage chambers and the portion of the plurality of reaction chambers to a first plurality of ports located on an inner surface of the cartridge housing. The hollow transfer module includes a second plurality of ports along an outer surface of the transfer module that lead to a central chamber within the transfer module. The transfer module is designed to move laterally within the cartridge housing. The lateral movement of the transfer module aligns at least a portion of the first plurality of ports with at least a portion of the second plurality of ports.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: May 10, 2016
    Assignee: STAT-Diagnostica & Innovation, S.L.
    Inventors: Jordi Carrera Fabra, Anna Comengés Casas, Rafael Bru Gibert
  • Patent number: 9333447
    Abstract: A device for separating particulate matter (e.g., cells) from a liquid including a housing defining an elongate chamber disposed between a receiving end and a dispenser end, a plunger slidably inserted within the chamber from the receiving end, an upper disc and a lower disc each independently slidably affixed to the plunger, the lower disc facing the dispenser end and including at least one filter arrangement, and a liquid including particulate matter disposed within the chamber when the upper disc and lower disc are in an aspiration mode. The upper disc is independently slidable with respect to the lower disc to achieve a filtration mode.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: May 10, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9316331
    Abstract: Multilevel microfluidic devices include a control line that can simultaneously actuate valves for both sample and reagent lines. Microfluidic devices are configured to contain a first reagent in a first chamber and a second reagent in a second chamber, where either or both of the first and second reagents are contained at a desired or selected pressure. Operation of a microfluidic device includes transmitting second reagent from the second chamber to the first chamber, for mixing or contact with the first reagent. Microfluidic device features such as channels, valves, chambers, can be at least partially contained, embedded, or formed by or within one or more layers or levels of an elastomeric block.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: April 19, 2016
    Assignee: Fluidigm Corporation
    Inventors: Geoffrey Facer, Brian Fowler, Emerson Cheung Quan, Marc Unger
  • Patent number: 9103766
    Abstract: The present invention can be described as an apparatus and cartridge for detecting the presence of an analyte in a fluid. The invention can also be described as a method of detecting the presence of an analyte in a fluid using the apparatus and cartridge. The method comprises the steps of clamping a sensor cartridge into a cartridge receiver of the apparatus, providing fluid to a fluid flow-path of the cartridge, illuminating at least a portion of a sensor, and using a photodetector to detect a change in the optical property of the sensor, wherein the change is caused by the presence or absence of an analyte in the fluid.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: August 11, 2015
    Assignee: Breath Diagnostics, LLC
    Inventors: Jerome J. Schentag, David T. D'Andrea, Frank V. Bright
  • Patent number: 9033307
    Abstract: A substrate of a lab-on-a-chip system has two adjacent recesses, one serving as a flow channel and the other one being filled with an elastomer compound. In a first state, the elastomer compound and the substrate delimit the flow channel in a section. In a second state, the elastomer compound takes up the space in the recess in the substrate along a cross-section of the flow channel, thereby completely closing the flow channel. The substrate and the elastomer compound may be produced by injection molding techniques.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: May 19, 2015
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Katja Friedrich, Walter Gumbrecht, Peter Paulicka
  • Patent number: 9017617
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 28, 2015
    Assignee: Luminex Corporation
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 8974731
    Abstract: A sample processing apparatus includes a sample carrier receiving region configured to receive a sample carrier. The sample carrier includes at least one sample channel carrying at least one sample, at least one agent chamber carrying at least one agent to be moved to the at least one sample channel to facilitate processing of the at least one sample, and the at least one agent chamber includes at least one chamber cover covering at least one opening of the at least one agent chamber, inhibiting flow of the at least one agent from the at least one agent chamber to the at least one sample channel. The sample processing apparatus further includes a chamber opener configured to facilitate opening the at least one chamber cover. The sample processing apparatus further includes a fluid mover that moves the agent out of the at least one agent chamber after the at least one chamber cover is opened and into the at least one sample channel.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: March 10, 2015
    Assignee: Analogic Corporation
    Inventor: Ari Eiriksson
  • Publication number: 20150050186
    Abstract: A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 19, 2015
    Inventors: Stefan Borja Bammesberger, Sabrina Kartmann, Peter Koltay, Klaus Mutschler, Juergen Spinke, Laurent Tanguy
  • Patent number: 8945485
    Abstract: A microfluidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: February 3, 2015
    Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
    Inventors: Hong Chen, Constantine Anagnostopoulos, Mohammed Faghri, Jeremy Cogswell
  • Patent number: 8945484
    Abstract: A microfluidic device including at least one microvalve which controls a flow of a fluid, where the at least one microvalve includes: a pneumatic layer, a fluidic layer disposed opposite to the pneumatic layer; an elastomer membrane disposed between the pneumatic layer and the fluidic layer; and an asymmetric valve seat protruding from a surface of the fluidic layer toward a surface of the elastomer membrane and asymmetrically dividing a space between the fluidic layer and the elastomer membrane.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: February 3, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kak Namkoong, Joon-ho Kim, Won-jong Jung, Chin-sung Park
  • Patent number: 8920753
    Abstract: A valve unit and an apparatus having the same include a plug which includes a phase change material in a solid state at a room temperature and a plurality of fine heat-dissipating particles dispersed in the phase change material. The fine heat-dissipating particles dispersed in the phase change material dissipate heat by absorbing an electromagnetic wave energy generated by electromagnetic wave radiation from the outside and block fluid flow in a path formed by a channel. As an external energy source irradiates an electromagnetic wave on the plug, the plurality of fine heat-dissipating particles dissipate heat and the phase change material becomes molten, thus opening the path to allow the fluid to flow.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: December 30, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jong-myeon Park, Jeong-gun Lee, Yoon-kyoung Cho
  • Patent number: 8911688
    Abstract: A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of the substrate in a fluid-tight manner by means of a clamping element. The clamping element and/or the valve body, or the sealing element, respectively, are at least partially elastic.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: December 16, 2014
    Assignee: Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E.V.
    Inventors: Rainer Gransee, Eva Schaeffer, Klaus-Stefan Drese, Silvio Kraus, Tobias Baier, Felix Schmitz
  • Patent number: 8906229
    Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: December 9, 2014
    Assignee: EMD Millipore Corporation
    Inventors: Sebastien Cirou, Rene Reinbigler, Virginie Buisson, Jean-Louis Weissenbach
  • Publication number: 20140328733
    Abstract: A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of DNA fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material. The biochip also includes a plurality of separation and detection chambers that physically separate different DNA fragments that have been marked with labels that emit similar colors, thereby enabling the independent detection of the different DNA fragments.
    Type: Application
    Filed: June 12, 2014
    Publication date: November 6, 2014
    Inventor: Ranjit A. PRAKASH
  • Publication number: 20140328732
    Abstract: A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 6, 2014
    Inventors: Peter Delmenico, Carlos G. Lopez-Espina, Gabriel Raviv
  • Patent number: 8838462
    Abstract: A computer system for analyzing a specimen processing workflow in a pathology laboratory including a display and a processor configured to provide a first interface, a second interface, and a third interface to the display, receive, via the first interface, a first set of parameters associated with an existing specimen processing workflow in a pathology laboratory, the first set of parameters including a workflow process and a workflow scale, and determine, based on the first set of parameters, current performance data of the existing specimen processing workflow having an associated current cost information and current time utilization.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: September 16, 2014
    Assignee: Dako Denmark A/S
    Inventors: Flemming Juncker, Mats Grahn, Nihad Hasagic
  • Patent number: 8834815
    Abstract: The invention relates to a valve structure for a microfluidic channel, where the valve serves the opening and closing of a channel (8) on a second level raised through channel pillars from the plane of the microfluidic channel network at the first level of a base plate (1), and where the channel wall is formed of a resilient material. The valve structure consists of a base plate (1) part, of protruding supporting walls (3, 3?) belonging to the base plate (1) and of a resilient part (7) between the supporting walls (3, 3?), within which the channel (8) is formed, and it consists furthermore of pressing appliances (9, 9?) situated on the two sides of the channel, as well as of displacement appliance (10) ensuring the movement of the pressing appliances in the direction of the mid-line of the channel (8).
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: September 16, 2014
    Assignee: Budapest Muszaki Es Gazdasagtudomanyi Egyetem
    Inventors: Hunor Santha, Gabor Harsanyi
  • Publication number: 20140242685
    Abstract: An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a throat, a valve space enclosing the valve body at least partly near the throat, a spring mechanism and a sealing element. The throat connects the blocking element to the pressing part and has an open passage region which opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body can be brought to an open position by pressing the pressing part against the spring mechanism.
    Type: Application
    Filed: August 28, 2012
    Publication date: August 28, 2014
    Applicant: TECAN TRADING AG
    Inventors: Marina Knoppke, Nico Birkner, Thomas Iten, Markus Wiggli
  • Patent number: 8778282
    Abstract: A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: July 15, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Won-jong Jung, Chin-sung Park, Kak Namkoong, Joon-ho Kim, Hyung-sok Yeo
  • Patent number: 8758687
    Abstract: The present invention is an apparatus and fluid delivery system for automated assays. The apparatus, for example, may be used for western blotting that uses flow lines for multiple reagents. In one embodiment, the present invention comprises a tray base with one or more fixed or disposable trays for testing samples, multiple flow lines, and multiple valves and the system is used for automatic controlled delivery of different fluids from supply vessels to different trays and discharges them to designated reservoirs or sewage system with minimum of operator actions. The system may include air line to assist supply and discharge the fluids and also coupled with measuring vessels with adjustable volume and valves adapted to interface with a valve operating unit with drive means.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: June 24, 2014
    Assignee: Precision Biosystems
    Inventors: Gregory Gorelik, Rus Yukhananov
  • Patent number: 8758708
    Abstract: It comprises, in addition to a sampling system (3), at the outlet of a vat (1) containing the liquid to be sampled, a selector (4) that establishes switching on an array of similar vats (1), and especially a suction unit (5) that operates by releasing compressed air into a nozzle (28); the airflow direction is controlled by a valve (29) between a direction directed toward the outlet (6), causing the suction of the liquid from the vat (1), and an opposite direction when the valve (29) is closed, feeding the liquid back into the vat (1) and cleaning the pipe (2).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 24, 2014
    Assignee: Commissariat a l'Energie Atomique et aux Enegies Alternatives
    Inventors: Christophe Brenneis, Hervé Lagrave, Jacques Mamert
  • Patent number: 8753587
    Abstract: A microvalve assembly (10) includes an elongate valve body (14) having opposed first and second major surfaces, the first major surface defining a valve recess (34) and the second major surface defining first and second fluid ports (20,22). Both the fluid input port and the fluid output port extend in fluid communication with the valve recess. A gasket (12) is freely positioned within the valve recess so as to extend in overlying registry with either or both of fluid ports. A valve cover (16) is bonded to the valve body and includes a first planar surface positioned in overlying registry with the valve recess so as to enclose the gasket therein. The valve cover is deflectable into the valve recess so as to cause the gasket to seal at least one of the fluid ports.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: June 17, 2014
    Assignee: General Electric Company
    Inventors: Victor Samper, Christian Rensch, Christoph Boeld, Marko Baller
  • Patent number: 8741234
    Abstract: A disposable blood analysis cartridge for analyzing a blood sample including an optical absorbance measurement channel is described. The optical absorbance measurement channel includes a plasma separation region and at least one sub channel including a cuvette that is in fluid communication with the plasma separation region and configured to receive a plasma portion of a blood sample that has been passed through the plasma separation region. A negative pressure may be applied to the cartridge to draw the sample through the plasma separation region and into the sub channel including the cuvette.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: June 3, 2014
    Assignee: Honeywell International Inc.
    Inventors: Tzu-Yu Wang, Ron Bardell, Lynn Seifried
  • Patent number: 8741233
    Abstract: A disposable blood analysis cartridge for analyzing a blood sample including an optical light scattering measurement channel is described. In use, processed sample may be introduced into a sheath fluid channel at an angle, ?, of approximately 90 degrees, relative to the direction of flow of the sheath fluid. In addition, delivering the sample from the side into the sheath fluid may facilitate better positioning of the core within the hydrodynamic focusing channel for measurement.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: June 3, 2014
    Assignee: Honeywell International Inc.
    Inventors: Ron Bardell, Tzu-Yu Wang, Mark Washa
  • Patent number: 8741235
    Abstract: A two-step method for loading a fluid sample into a disposable fluid analysis cartridge is described. First, capillary action may be used to initially draw a sample through a sample introduction port and into a sample collection reservoir provided in the fluid analysis cartridge. Once the fluid sample has been drawn into the sample collection reservoir by capillary action, a negative pressure may be applied to the cartridge to pull the sample from the sample collection reservoir and into a sample loading channel. A valve may be disposed between the sample collection reservoir and the sample loading channel to prevent backflow of sample into the sample collection reservoir and to retain sample in the sample loading channel.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: June 3, 2014
    Assignee: Honeywell International Inc.
    Inventors: Robert Janisch, Pam Wong, Eric Peltola, Ron Bardell, Mark Kelley
  • Publication number: 20140147923
    Abstract: Methods and systems for testing fluid samples include a diffused air flotation (DAF) system and a jar. The jar includes a diffuser for injecting the diffused air into the jar and a tap for drawing a fluid out of the jar.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 29, 2014
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Stephen J. Wiacek, Bingbing Guo
  • Publication number: 20140127792
    Abstract: A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 8, 2014
    Applicant: Illumina, Inc.
    Inventors: Robert C. Kain, Alexander G. Dickinson, Min-Jui Richard Shen, Helmy A. Eltoukhy, Francisco Jose Garcia
  • Patent number: 8709787
    Abstract: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: April 29, 2014
    Assignee: Handylab, Inc.
    Inventor: Kalyan Handique
  • Patent number: 8697009
    Abstract: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 15, 2014
    Assignee: Micronics, Inc.
    Inventors: Patrick Saltsman, Mingchao Shen, Jeffrey M. Houkal, Christy A. Lancaster, C. Frederick Battrell, Bernhard H. Weigl
  • Patent number: 8685341
    Abstract: Provided herein are systems and methods for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. For example, provided herein is a device with three groups of independently controllable components, where the first group includes a first lead and a first heater configured to heat a valve; where the second group includes a second lead and a second heater configured to heat a reaction chamber; where the third group includes a third lead and the first and second heaters; and where the first heater is independently controllable via a combination of the first lead and the third lead, and the second heater is independently controllable via a combination of the second lead and the third lead.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: April 1, 2014
    Assignee: HandyLab, Inc.
    Inventor: Karthik Ganesan
  • Publication number: 20140079605
    Abstract: A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 20, 2014
    Applicant: NEC CORPORATION
    Inventors: Minoru ASOGAWA, Hisashi HAGIWARA, Tohru HIRAMATSU
  • Patent number: 8669096
    Abstract: Systems and methods for isolating samples are provided. The system comprises a first membrane and a second membrane disposed within an enclosure. First and second reservoirs can also be disposed within the enclosure and adapted to contain one or more reagents therein. A first valve can be disposed within the enclosure and in fluid communication with the first reservoir, the second reservoir, or both. The first valve can also be in fluid communication with the first or second membranes or both. The first valve can be adapted to selectively regulate the flow of the reagents from the first reservoir, through at least one of the first and second membranes, and into the second reservoir.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: March 11, 2014
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Ye Zhang, Honglu Wu
  • Patent number: 8663583
    Abstract: A disposable blood analysis cartridge may include a sample collection reservoir, an absorbance measurement channel, and an optical light scattering measurement channel. One or more valves may be disposed between the sample collection reservoir and the absorbance measurement channel and/or the optical light scattering measurement channel. A negative pressure may be applied to the cartridge to pull sample from the sample collection reservoir through the one or more valves and into the absorbance measurement channel and/or the optical light scattering measurement channel. Once the sample is pulled into the absorbance measurement channel and/or the optical light scattering measurement channel, the one or more valves may be closed. With the one or more valves closed, and in some cases, a pusher fluid may be provided to push the fluid sample to other regions of the disposable fluid blood analysis cartridge.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: March 4, 2014
    Assignee: Honeywell International Inc.
    Inventors: Mark Kelley, Ron Bardell, Robert Janisch, Pam Wong, Eric Peltola
  • Patent number: 8658113
    Abstract: Provided are a thin film valve device and a thin film valve control apparatus in which a hole or a channel in the body of the thin film valve device is opened and closed using the heat generated from a heat generating apparatus and the centrifugal force. The thin film valve device and the thin film valve control apparatus are applicable to, for example, a diagnostic lab-on-a-chip that can detect a trace amount of a material in a fluid, a rotatable bio-disc in which a bio chip, such as a protein chip and a DNA chip, is integrated, and the like.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: February 25, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Jae Chern Yoo
  • Patent number: 8641988
    Abstract: A sample analyzer which transports a rack holding a plurality of sample containers and analyzes samples includes: a first measurement apparatus which measures samples; a second measurement apparatus which is arranged downstream, in a transport direction, from the first measurement apparatus, and which measures samples; and a transporting apparatus which transports samples to a first supply position for supplying a sample to the first measurement apparatus, and to a second supply position for supplying a sample to the second measurement apparatus. The transporting apparatus linearly transports a rack from the first supply position to the second supply position, and the distance between the first supply position and the second supply position is a multiple of the distance between adjacent sample containers held in the rack.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: February 4, 2014
    Assignee: Sysmex Corporation
    Inventors: Toru Mizumoto, Takayoshi Izumi, Keisuke Tsutsumida, Shinya Nakajima
  • Patent number: 8636964
    Abstract: An end-face sealing fluidic connector for fluidic connection and/or interconnection of glass, glass-ceramic and/or ceramic fluidic modules in a microreactor includes a connector body having a circular first end face with a recess for retaining one or more O-rings and a first end section having a circular cylindrical outeT surface and a diameter In the range of from 3 to 25 mm. The outer surface has a circumferential recess dividing the first end section into a proximal portion adjacent the first end face and a distal portion. A retaining ring is seated in the circumferential recess and a protecting ring coinpming a high-compression-strength polymer surrounds the proximal portion of the first end section. A circular cylindrical sleeve surrounds the first end section and the reinforcing and/or protecting ring, the sleeve including a circumferentially extending inside bearing surface for engaging the retaining ring on the distal side thereof.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: January 28, 2014
    Assignee: Corning Incorporated
    Inventors: Pierre Brunello, Paul Louis Florent Delautre, Sylvain Maxime F Gremetz, Olivier Lobet
  • Patent number: 8616227
    Abstract: Multilevel microfluidic devices include a control line that can simultaneously actuate valves for both sample and reagent lines. Microfluidic devices are configured to contain a first reagent in a first chamber and a second reagent in a second chamber, where either or both of the first and second reagents are contained at a desired or selected pressure. Operation of a microfluidic device includes transmitting second reagent from the second chamber to the first chamber, for mixing or contact with the first reagent. Microfluidic device features such as channels, valves, chambers, can be at least partially contained, embedded, or formed by or within one or more layers or levels of an elastomeric block.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: December 31, 2013
    Assignee: Fluidigm Corporation
    Inventors: Geoffrey Facer, Brian Fowler, Emerson Cheung Quan, Marc Unger
  • Patent number: 8617905
    Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: December 31, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Mark A. Burns, Brian N. Johnson, Michael Chen
  • Patent number: 8591834
    Abstract: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: November 26, 2013
    Assignee: Fluidigm Corporation
    Inventors: David S. Cohen, Robert C. Jones, Andrew May, Hany Nassef, Jing Wang
  • Patent number: 8591810
    Abstract: An apparatus (10, 60, 70, 100, 110, 120) for handling specimen slides (21) encompasses a coverslipping module (14) for coverslipping thin sections arranged on the specimen slides (21), the coverslipping module (14) applying first a mounting medium and then a coverslipping means onto the specimen slides (21). The apparatus (10, 60, 70, 100, 110, 120) further has an output unit (18) for outputting the specimen slides (21), which unit encompasses a drying unit (32) for at least partial extraction of at least one solvent from the applied mounting medium of the specimen slides (21) arranged in the output unit (18).
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: November 26, 2013
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Bernhard Neef
  • Patent number: 8585985
    Abstract: An apparatus for staining sample sections, comprising: a chamber that is adapted for fastening sample sections therein; and a pump that is adapted for pumping liquids through the chamber. The chamber has an inlet and an outlet. The inlet can be connected to at least one reservoir of a staining liquid via inlet lines that are controllable by valves. The inlet lines are formed at least in the region of the associated valves by means of elastic hose lines, and the valves are formed as hose pinch valves. This apparatus minimizes or eliminates contaminations arising from staining processes for thin sections that are in particular prepared for examination in an electron microscope.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: November 19, 2013
    Assignee: Leica Mikrosysteme GmbH
    Inventors: Reinhard Lihl, Heinz Plank, Siegfried Tanki