Tube Shaped Vessel Patents (Class 422/549)
  • Patent number: 10335121
    Abstract: A receiver for urine whether for taking sample or disposing thereof, includes an open-topped of saddle shape which approximates the configuration of thighs, labia or other convenient zone.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: July 2, 2019
    Inventor: Akhil Rajendra Desai
  • Patent number: 10058470
    Abstract: Methods and devices for holding liquid or solid materials including a cylindrical container, a holder, and a detachable handle, the handle capable of being adjusted to variable angles when coupled to the holder. Method of collecting material including the step of holding a graduated cylindrical container by a detachable variable angle handle. A kit for a female urinary cup for holding liquid or solid materials comprising a cylindrical container including exterior threads on which a cap may be screwed, a holder attached to a sidewall of the container, a detachable handle optionally coupled to the holder, the handle capable of being adjusted to variable angles when coupled to the holder, and instructions for use of the female urinary cup.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: August 28, 2018
    Inventor: Jerry P. Phillips
  • Patent number: 10039867
    Abstract: A method for recovering blood from a blood-laden surgical sponge for autologous reinfusion, the method comprising the steps of: conveying negative pressure to a housing with the blood-laden surgical sponge; applying a predetermined force to draw the blood from the surgical sponge; and collecting the recovered blood.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: August 7, 2018
    Assignee: PROCELL SURGICAL INC.
    Inventors: Robert Krensky, David G. Matsuura, Philip J. Simpson
  • Patent number: 9962700
    Abstract: An analyzing device includes: an operation cavity that is adjacent to a first reserving cavity retaining a sample liquid, in a circumferential direction of rotational driving; a connecting section provided on a side wall of the first reserving cavity to suck the sample liquid by a capillary force and transfer the sample liquid to the operation cavity; and second reserving cavities that are disposed outside the operation cavity in the circumferential direction of the rotational driving and communicate with the outermost position of the operation cavity through a connecting passage. The connecting section is circumferentially extended farther than the liquid level of the sample liquid retained in the first reserving cavity.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: May 8, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventor: Hiroshi Saiki
  • Patent number: 9618526
    Abstract: An automated analyzer that can effectively reduce contamination of a diluted low-concentration specimen resulting from a high-concentration specimen not being diluted. The automated analyzer includes a specimen nozzle that performs both the function of pipetting a specimen from a specimen container accommodating the specimen and the function of pipetting a specimen diluted by the analyzer, and means for washing the specimen nozzle with a predetermined detergent. When a pipetting process of a high-concentration specimen not being diluted and a pipetting process of a low-concentration specimen diluted by the analyzer are consecutively performed for the same specimen by the specimen nozzle, between the pipetting process of a high-concentration specimen and the pipetting process of a low-concentration specimen, the analyzer performs a washing processing in which the specimen nozzle is washed with the predetermined detergent.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: April 11, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshiaki Saito, Yoichi Aruga, Toshihide Orihashi
  • Patent number: 9283704
    Abstract: A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: March 15, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: Brian F. Ahern, Donald J. Carano, Nicholas A. Grippi, Paul R. Soskey, Gregory L. Lusardi
  • Patent number: 9040000
    Abstract: Devices and methods are described herein that are configured for use in laboratory testing, such as, for example, during a procedure including the monitoring and detection of chemical reactions. For example, the systems and devices described herein can be used during a procedure to monitor and detect polymerase chain reactions (PCR). In some embodiments, a sample container includes a container body that defines an interior volume and has an open end in fluid communication with the interior volume. A cap is sealingly engageable with the open end of the container body. The cap defines a receptacle that is configured to extend within a portion of the interior volume of the container body when the cap is sealingly engaged thereto. The receptacle can receive therein a sensor, such as, a temperature sensor that can monitor the temperature of a sample material disposed within the container body.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: May 26, 2015
    Assignee: Heatflow Technologies Inc.
    Inventor: Warren L. Dinges
  • Publication number: 20150132185
    Abstract: A multi vessel ring (suitable for use with thermal cycler and PCR apparatus) comprises a ring body and a plurality of elongate tubes. Each tube has a proximal open end and a distal closed end, each elongate tube being integrally formed with the ring body, and being pivotally connected to the ring body between an initial position in which a longitudinal axis of each tube is generally parallel with an axis of rotation of the ring body, and a final position in which the longitudinal axis of each tube is inclined relative to the axis of rotation of the ring body. The multi vessel ring preferably further comprises a plurality of caps integrally formed with the ring body, and adapted to seal the proximal open end of respective tubes.
    Type: Application
    Filed: July 13, 2011
    Publication date: May 14, 2015
    Applicant: CHROMOPLAS PTY LTD
    Inventor: Anania Albert Khamu
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9012206
    Abstract: The invention provides methods of performing a sizing analysis. In the methods, a sizing ladder used in performing the sizing analysis is corrected. In one method, the sizing ladder is corrected for batch-to-batch variations in a sieving gel. In another method, the sizing ladder is corrected for a sample concentration that is different from the archival sizing ladder concentration. Methods are also provided in which the sizing ladder is corrected using a standard marker in a sample and/or using a real-time standard sizing ladder. The methods may be used individually or in combination.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: April 21, 2015
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Dan Camporese, Advit Bhatt, Josh Molho, Hui Xu, Ken Summers
  • Publication number: 20150105300
    Abstract: A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Inventors: Shuqi Chen, Lingjun Chen
  • Patent number: 9005551
    Abstract: A sample vessel may include a segmented tubule and an interface receiving the tubule. The segmented tubule may include an opening for receiving a sample material and at least one compressible section, the at least one compressible section having a wall constructed at least partially from a material having sufficient flexibility to permit compression of opposed sections of the wall into contact with one another, and at least two segments of the tubule being fluidically isolated from one another by a bonding of a fluid-tight seal between opposed sections of the tubule wall, wherein said fluid-tight seal irreversibly opens upon application of fluid pressure greater than a threshold value to permit selective fluid communication between the opposed sections. The interface may facilitate delivery of a sample material to the tubule through the opening.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: April 14, 2015
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Shuqi Chen, Lingjun Chen
  • Patent number: 8999729
    Abstract: A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end opposite to the end, and a matrix for separating agglutinates from non-agglutinates; wherein the device further comprises a rotating support able to rotate around an axis and holding pivotally the reaction vessels in a way to allow the reaction vessels to pivot about an axis essentially perpendicular to the rotation axis of the support when the latter is rotated, such that the fluids remain in the upper chamber when the support is not rotated, and can flow from the upper chamber to the lower chamber and into the matrix when the support is rotated.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Symbion Medical Systems Sarl
    Inventors: Isabelle Delafosse, Fabrice Ummel, Antonio Yanez
  • Patent number: 8999273
    Abstract: A system for preparing and holding specimens for microscopic analysis including a capsule having an open end, an opposite end including at least one aperture and a reservoir. The system also includes an insert with a base including at least one aperture. The insert fits within and engages an inner wall of the reservoir to secure the insert within the reservoir. The system also includes an insertion tool configured to engage the insert. The insertion tool is sized to position the insert within the reservoir at a variety of positions within the reservoir. The insertion tool will disengage the insert once the insert is positioned within the reservoir. A method of positioning a specimen within a capsule for processing the specimen in preparation for microscopic analysis. A tray for holding a plurality of pipette tips in such a way that a lower end of each pipette tip is sealed.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: April 7, 2015
    Assignee: Microscopy Innovations, LLC
    Inventors: Steven L. Goodman, Mark T. Nelson, Jack C. LaSee
  • Patent number: 8992862
    Abstract: A separation device including a first buoy, a second buoy, a first valve, and a second valve. The first buoy is mounted to a buoy guide post and slidably mounted within a separation chamber. The second buoy is slidably mounted to the guide post and movable between a first position and a second position. The second buoy closes the first valve and opens the second valve when in the first position. The second buoy opens the first valve and closes the second valve when in the second position. The second buoy has a density such that after spinning the device for a suitable period of time a first component of the composition is isolated between the first buoy and the second buoy and a second component of the composition is isolated between the second buoy and the end of the separation chamber that is opposite to a port.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 31, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Jason Chavarria
  • Publication number: 20150087555
    Abstract: The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 26, 2015
    Inventor: Marcella CHIARI
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Patent number: 8961907
    Abstract: The invention relates to apparatus for the detection of particles and for particle analysis. The apparatus comprises a sample holder comprising a base and a projection extending from the base. The base includes a contact region where, in use, the surface of a fluid sample may contact the projection. The surface of at least the contact region of the projection exhibits properties that allow the surface of the contact region to be substantially wetted by a fluid sample when the apparatus is in use so that the fluid sample forms a meniscus having its apex in contact with the contact region of the projection. The invention also relates to methods for using the apparatus.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: February 24, 2015
    Assignee: Menixis Limited
    Inventor: Stephen John Sowerby
  • Kit
    Patent number: 8940248
    Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: January 27, 2015
    Assignee: Eppendorf AG
    Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
  • Publication number: 20150017078
    Abstract: Sample handling system for handling samples contained in tubes (4), each tube (4) having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube (4). The system comprises a micro-plate (1) comprising at least one grid insert (2) having a plurality of compartments. Each compartment comprises one or more side walls laterally confining a through-hole for receiving a said tube (4). The through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening. A frame (3) to which the at least one separate grid insert (2) is to be attached to form the micro-plate (1). The frame (3) laterally confines a through-opening which is dimensioned to allow for accessing each compartment (21) of the attached at least one grid insert (2) from above and from below. This allows for moving such tube (4) into and out of each compartment (21) through each of the top opening (202) and the bottom opening (203) of the through-hole (201).
    Type: Application
    Filed: February 1, 2013
    Publication date: January 15, 2015
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Christof Fattinger, Tom Kissling, Thomas Zumstein
  • Patent number: 8925734
    Abstract: A filter vial and piston are provided where the vial has a cylindrical wall with a closed bottom and open top and with the hollow, tubular piston therein. The piston has a distal end covered by a cup having a proximal cup seal extending outward to engage the walls of the vial to form a fluid tight seal with the vial during use. The distal end of the piston has a piston flange extending outwardly and located adjacent a recess in the piston so the cup forms a snap fit over the piston flange and extends into the recess. The piston flange causes the cup to bulge sufficiently outward to form a fluid tight seal with the vial during use. A filter is placed in the bottom of the cup and abuts an inwardly extending lip on the cup. The filter is held against the lip by a piston support at the distal end of the piston. A cup support at a distal end of the cup also helps support the filter.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: January 6, 2015
    Assignee: Scientific Plastic Products, Inc.
    Inventors: Samuel A. Ellis, Kishan G. Hingorani
  • Patent number: 8911689
    Abstract: An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 16, 2014
    Assignee: General Electric Company
    Inventors: Victor Donald Samper, Christian Rensch, Christoph Boeld, Xavier Franci
  • Patent number: 8900514
    Abstract: The invention discloses a blood analyzing device (100) comprising a holder (110) arranged for carrying a container (10) having a cuvette (20) containing a blood sample (30). The container (10) is positioned in the holder (110) so that a longitudinal axis (60) of the cuvette (20) is angled relative a horizontal axis (70). A light source (120) provides light (40) into the sample (30) and a detector (130) detects the output light (50) from a sub-portion of the blood sample (30). Kinetic information indicative of the change in hemoglobin concentration in a measuring volume (32, 34) is determined by a Hb processor (145) from the detected output light (50). An ESR processor (140) determines the erythrocyte sedimentation rate of the sample (30) based on the kinetic information.
    Type: Grant
    Filed: September 1, 2008
    Date of Patent: December 2, 2014
    Inventor: Tommy Forsell
  • Patent number: 8900875
    Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 2, 2014
    Assignee: Shell Oil Company
    Inventors: Abraham Robert De Kraker, Liliana Minevski, Tze Lee Phang
  • Patent number: 8889086
    Abstract: An improved tube including a closure portion, a strap integrally connected to the closure portion and being configured for defining a living hinge, a body portion having a longitudinal axis and an outer wall generally circumscribing the longitudinal axis, and being integrally and hingedly connected with the closure portion by way of the strap. The body portion including a sample portion being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wall dimension of the sample portion reduces to a smaller second outer wall dimension.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: November 18, 2014
    Assignee: Streck, Inc.
    Inventors: Hendrik J. Viljoen, Scott E. Whitney, Joel R. TerMaat, Matthew R. Kreifels
  • Patent number: 8871524
    Abstract: The invention provides methods of performing a sizing analysis. In the methods, a sizing ladder used in performing the sizing analysis is corrected. In one method, the sizing ladder is corrected for batch-to-batch variations in a sieving gel. In another method, the sizing ladder is corrected for a sample concentration that is different from the archival sizing ladder concentration. Methods are also provided in which the sizing ladder is corrected using a standard marker in a sample and/or using a real-time standard sizing ladder. The methods may be used individually or in combination.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: October 28, 2014
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Dan Camporese, Advit Bhatt, Josh Molho, Hui Xu, Ken Summers
  • Patent number: 8871160
    Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: October 28, 2014
    Assignee: K-MAC
    Inventors: Sung-Min Seo, Jae-Hyung Park, Oleksandrov Sergiy, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Publication number: 20140301914
    Abstract: A blood storage container suitable for quick and efficient production of a large amount of serum while ensuring high safety, a method of separating blood and a regenerative medical process using the same, and a serum preparation apparatus are provided. A blood component separator is provided, which separates collected blood into a plurality of blood components and preserves them, and includes a blood reservoir and a component storage part aseptically connected in an air-tight manner. The blood reservoir has a serum producing function to remove coagulation factors from the blood. The component storage part stores each blood component in the blood reservoir. The serum preparation apparatus includes an indwelling needle, a catheter having one end connected to a base end side of the indwelling needle, a syringe capable of storing blood connected to another end of the catheter, and a blood coagulation accelerating substance stored in the syringe.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 9, 2014
    Inventors: Koji SUZUKI, Junya FUJII, Mari TAKABATAKE, Seishin TANAKA, Ken KONDO
  • Patent number: 8852532
    Abstract: A g-force-sensitive label for detecting and indicating the application of a g-force is provided, the g-force sensitive label comprising an area for detecting and indicating an application of a g-force above a threshold value on the g-force sensitive label and an attachment area for attaching the g-force sensitive label on an object. At least one physical property of the area measurably changes its state upon applying a g-force above the threshold value, thereby altering a displayed pattern such that a machine-readable 1D or 2D or alphanumeric code is displayed.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: October 7, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frederic Furrer, Mark James Simmons
  • Patent number: 8834807
    Abstract: The invention provides devices and methods for isolating one or more sample components of a sample material following separation of the sample material into a plurality of sample components. A device includes a separation channel having a sample loading well. A low-conductivity buffer is disposed in the loading well, the buffer having a conductivity<0.2 mS/cm. In a method, a buffer is loaded into a loading well in fluid communication with a separation channel of a device. A sample material having a conductivity higher than that of the buffer is then loaded into the loading well such that the sample material is disposed beneath the buffer, the buffer disposed over and covering the sample material. The sample material is separated into a plurality of separated components in the separation channel, and a separated component is collected from a collection well disposed in a collection leg of the device.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: September 16, 2014
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Josh Molho, Hui Xu
  • Patent number: 8815181
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: August 26, 2014
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventor: David James Squirrell
  • Patent number: 8808551
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 19, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Patent number: 8790598
    Abstract: The present invention provides reaction cells capable of maintaining stable analytical performance by preventing bubble adhesion and reducing sample carryover even if the amount of sample liquid for a single test is further reduced in the future. The invention further provides an automatic analyzer that uses the reaction cells and a method for enhancing the hydrophilicity of the inner surfaces of the reaction cells. According to the invention, a reaction cell has a first electrode inserted thereinto and a second electrode disposed on the bottom side of the reaction cell. A voltage is applied between the first electrode and the second electrode to cause electric discharge between the electrodes. This allows for enhancing only the hydrophilicity of the bottom inner surface and the four bottom corners of the reaction cell to which large bubbles adhere easily.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: July 29, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masashi Endo, Hiroaki Ishizawa, Hiroyuki Mishima
  • Publication number: 20140206088
    Abstract: The embodiments disclosed herein relate to unitized reagent strips for holding and transporting reagents and materials used in automated sample preparation and/or processing for biological and or chemical assays.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 24, 2014
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: Ammon David Lentz, Richard St. Pierre, Dwight Livingston, Adam Bruce Steel
  • Patent number: 8778283
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: July 15, 2014
    Assignee: The Secretary of State for Defence
    Inventor: David James Squirrell
  • Patent number: 8758706
    Abstract: A device is provided by means of which biomolecules in samples in a volume range from <1 ?l to 500 ?l can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 24, 2014
    Assignee: SCIENOVA GmbH
    Inventors: Heidrun Rhode, Stefan Kreusch, Helga Endmann, Michael Händel, Günther Sammler, Edith Zimmermann
  • Publication number: 20140161688
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. The cannula extends into a chamber at a first end of the collector that holds the processing vessel. In one implementation, the processing vessel is empty. In another implementation, the processing vessel includes at least one displacement fluid. In yet another implementation, the processing vessel may include at least one displacement fluid and at least one processing solution.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Erik Lundt
  • Patent number: 8747670
    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: June 10, 2014
    Assignee: EMD Millipore Corporation
    Inventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
  • Patent number: 8747677
    Abstract: A magnetic separation device comprising a magnetic base and a retention mechanism, as well as a method of evacuating liquid from a well plate containing liquid and magnetic particles, are disclosed. In specific embodiments, the retention mechanism comprises one or more wire clips. In certain embodiments, the magnetic base comprises apertures configured to receive the wire clips. The retention mechanism can be configured to secure a well plate to the magnetic base so that a user may evacuate liquid from a well plate containing liquid and magnetic particles. In certain embodiments, the method comprises inverting the magnetic separation device and well plate. In particular embodiments, the method comprises rapidly and forcefully inverting magnetic separation device and well plate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: June 10, 2014
    Assignee: Luminex Corporation
    Inventors: Tracy Vandenbroek, Mark Coffey, Jarden Krager
  • Patent number: 8747780
    Abstract: An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: June 10, 2014
    Assignee: McLuen Design, Inc.
    Inventors: Gary R. McLuen, Richard J. Hanney, Daniel W. Hugens
  • Publication number: 20140140902
    Abstract: An apparatus for collecting an organism from a culture medium includes a collecting tube having a cutting end portion, and a suction unit connected to the collecting tube. The collecting tube is capable of penetrating into and incising the organism in the culture medium. The suction unit is capable of generating a suction force to draw the incised organism from the culture medium through the cutting end portion.
    Type: Application
    Filed: November 19, 2012
    Publication date: May 22, 2014
    Inventor: Kuan-Nan Chen
  • Patent number: 8727133
    Abstract: Method for the preparation of at least one compound with biological properties from blood, where said method is performed in sealed tubes at a pressure below atmospheric pressure, thereby reducing or preventing the bacterial contamination of the compound through handling. The method comprises the repetition, for as many times as is required, of the following steps: connecting a second container that is vacuum-sealed to an extraction device connected in turn to a first container that contains blood separated into fractions, waiting for a period of time until the required fraction(s) is/are transferred, and removing said second container, with it thus being possible to obtain several second containers with different compounds for different medical applications including biological therapies. The steps may be performed in a closed system, without removing the caps of the containers, or alternatively the first container may be opened prior to the introduction of the extraction device.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: May 20, 2014
    Assignee: Biotechnology Institute, I Mas D, S.L.
    Inventor: Eduardo Anitua Aldecoa
  • Patent number: 8728414
    Abstract: A closure for a container has a closure body having a first cylindrical portion and a second cylindrical portion opposite the first portion. The closure also has a connector disposed in at least one of the first and second portions. The connector is adapted to connect one of a sample collection device and an applicator to the closure. A containing apparatus including the closure, a container, and optionally one of a sample collection device and an applicator is also disclosed. A method of using the containing apparatus is also disclosed.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: May 20, 2014
    Assignee: DNA Genotek Inc.
    Inventors: Michael Beach, Roy Sunstrum, Maurice Lavimodiere, Adele Jackson, Rafal Michal Iwasiow, Ellen Maclean, H. Chaim Birnboim
  • Publication number: 20140112842
    Abstract: An automated sample tube blotting system having one or more rotating grippers, a supply of absorbent material, a transporter, and an absorbent material removal mechanism. Each rotating gripper has a respective holder configured to selectively mate with a respective interface on a tube strip, and the one or more rotating grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the rotating gripper in a lateral direction from a starting location to a location above the absorbent material, and in a vertical direction towards and away from the absorbent material.
    Type: Application
    Filed: October 22, 2012
    Publication date: April 24, 2014
    Applicant: QIAGEN GAITHERSBURG, INC.
    Inventors: Bradley Scott Thomas, Brian Austin Self, Eric Schneider, Franklin Regan
  • Publication number: 20140112843
    Abstract: An automated sample tube decanting system having one or more decanting grippers, a decant waste receptacle, a transporter, and means for rotating the decanting gripper. Each decanting gripper has a respective holder configured to selectively mate with a respective interface on a tube strip. The one or more decanting grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the one or more decanting grippers in a lateral direction from a starting location to a location above the decant waste receptacle.
    Type: Application
    Filed: October 22, 2012
    Publication date: April 24, 2014
    Applicant: QIAGEN GAITHERSBURG, INC.
    Inventors: Bradley Scott Thomas, Brian Austin Self, Andrew Leonard, Bert Jungheim, Eric Schneider, Franklin Regan, Bowen Cui, Shubing Liu
  • Patent number: 8703072
    Abstract: A meniscus reducing member for use in a vessel for containing a liquid including a surface feature overlying at least a portion of an interior surface of the vessel. The surface feature includes at least two surfaces for contacting the liquid that cooperate to reduce a width of a meniscus formed at an interface between the liquid and the surface feature by physically altering a contact angle between the liquid and the surface feature.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: April 22, 2014
    Inventors: Oliver Egeler, Steven M. Woodside
  • Publication number: 20140106445
    Abstract: A method for transferring a quantity of analytes comprising at least stages of: predisposing a substantially homogeneous mixture of a predetermined initial quantity of at least an analyte and a liquid, obtaining a known concentration value or known amount of the analyte in the mixture; introducing into the mixture at least a collecting portion (3) of a sampling device (1) having a support body (2), the collecting portion (3) comprising a plurality of fibers (6) attached to and arranged on a first portion (2a) of the support body (2) by means of flocking, in order to define a flocked collecting portion (3) or a flocked tampon, such as to collect a part of the mixture on the collecting portion (3); and extracting the collecting portion (3) of the sampling device (1) of the mixture, retaining on the sampling portion (3) a predetermined known quantity of the mixture to be transferred.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 17, 2014
    Applicant: Copan Italia S.p.A.
    Inventor: Daniele Triva
  • Patent number: 8679424
    Abstract: A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 ?·cm and 5×1013 ?·cm or less.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 25, 2014
    Assignee: Seiko Epson Corporation
    Inventor: Hiroshi Koeda
  • Patent number: 8673242
    Abstract: An over-torque resistant vial and closure assembly includes a vial having an outwardly projecting rib that cooperates with a stop surface provided on a closure. When the closure is threadably coupled to the vial, the stop surface of the closure engages the outwardly projecting rib of the vial so as to prevent over-torquing of the closure onto the vial.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: March 18, 2014
    Assignee: National Scientific Company
    Inventor: Leemen Loy Shick
  • Publication number: 20140050619
    Abstract: A reaction vessel (1) with an enclosing wall (4) and an opening (6) for holding liquids to be analyzed enables particularly flexible automatic processing and, at the same time, high quality measurement results. To this end, the enclosing wall (4) comprises a first section (10), in which at least the external surface has a substantially circularly symmetric design, and a second section (12), which has at least two planar areas (14), which comprise a light-transmissive material, are opposite to one another and arranged in parallel, and wherein the reaction vessel (1) has a means (12, 22, 26) for orienting the reaction vessel (1) in a receiving position.
    Type: Application
    Filed: August 15, 2013
    Publication date: February 20, 2014
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventor: Paul Meller