Container Patents (Class 422/547)
  • Patent number: 10948508
    Abstract: A transport device unit for a transport device assembled using a plurality of transport device units is presented. The transport device unit comprises a base plate module with a base plate for fixing the transport device unit to a support frame, an actuator module with a plurality of electro-magnetic actuators, where the actuator module is supported by the base plate module, and a driving surface module with a driving surface element, where the driving surface element is arranged above the actuator module covering the actuators and configured to carry sample container carriers. A transport device, a system for at least partially disassembling the transport device, and a laboratory sample distribution system comprising a transport device are also presented. In addition, a laboratory automation system comprising a laboratory sample distribution system is also presented.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: March 16, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans Schneider, Eugen Lusser, Marcel Kaeppeli, Tobias Huber, Hermann Pius, Matthias Edelmann
  • Patent number: 10766031
    Abstract: The present disclosure relates to a microfluidic-based analyzer, including a drive module and a microfluidic disc. On the microfluidic disk, a capillary is connected between a mixing chamber and a waste chamber. More particularly, the capillary is connected to the mixing chamber through a first access on the first radius of the microfluidic disc, and the capillary is connected to the waste chamber through a second access on the second radius of the microfluidic disk. Specifically, a turn of the capillary is disposed between the first access and the second access, in which a folding is configured on a third radius of the microfluidic disc. Overall, the aforementioned microfluidic-based analyzer is able to be operated in different rotational speeds and is capable of evacuating the mixing chamber and enhancing the washing efficiency.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: September 8, 2020
    Assignee: FENG CHIA UNIVERSITY
    Inventors: Chih-Hsin Shih, Ho-Chin Wu, Yen-Hao Chen
  • Patent number: 10758211
    Abstract: A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container includes an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: September 1, 2020
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Timothy R. Hansen, Mark Talmer, Kevin Bailey, Dwight Livingston
  • Patent number: 10739358
    Abstract: Portable coagulation monitoring devices, systems, and methods are disclosed. Namely, a test cartridge is provided for use in a portable coagulation monitor (PCM) device. Further, the test cartridge comprises two glass-filled thermoplastic polymer plates and a disposable blood introduction device. The two glass-filled thermoplastic polymer plates are arranged substantially in parallel with a small gap therebetween for receiving a sample of blood to be tested. Using the PCM device, the two glass-filled thermoplastic polymer plates can be moved linearly relative to each other. Methods of measuring coagulation response in a blood sample using the test cartridge and the PCM device are provided. A method of introducing blood into the test cartridge using the disposable blood introduction device is provided.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 11, 2020
    Assignee: ENTEGRION, INC.
    Inventors: Matthew Pearce, Richard Hall, Joseph Anthony Dacorta
  • Patent number: 10717087
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: July 21, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
  • Patent number: 10712244
    Abstract: Provided is a specimen staining apparatus that includes a gap-forming member arranged to form a gap having a thickness that induces capillary action, the gap being formed above a mounting surface of a slide glass having a specimen mounted thereon; and a chemical solution supply unit that supplies a chemical solution for staining the specimen to the gap between the gap-forming member and the mounting surface so that the chemical solution spreads within the gap due to capillary action and is evenly supplied to the specimen placed on the mounting surface.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 14, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Yoshihiro Kawano, Kei Tsuyuki, Asuka Yamamoto
  • Patent number: 10688458
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 23, 2020
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
  • Patent number: 10688209
    Abstract: A system includes a radiation containment chamber, an isolator connected to the radiation containment chamber, a rotating transfer door positioned between the radiation containment chamber and the isolator, and an antimicrobial vapor generator connected to the isolator. The rotating transfer door includes a cavity for receiving a radionuclide generator column assembly, and is rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator. The transfer door is adapted to rotate while antimicrobial vapor is introduced into the isolator by the antimicrobial vapor generator.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 23, 2020
    Assignee: Curium US LLC
    Inventors: John Schmitz, Michael J. D'Hooge, Andrew M. Schadt, Gregory Bengard, Sumit Verma, Kevin B. Graves, Bryan S. Petrofsky
  • Patent number: 10662485
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 26, 2020
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Patent number: 10634690
    Abstract: According to one embodiment, there is provided an automatic analyzing apparatus which comprises determination processing circuitry, an analyzer mechanism and data processing circuitry. The determination processing circuitry determines whether to continue reaction of a solution mixture based on reaction data. The analyzer mechanism generates analytical data based on test data generated by measuring the solution mixture. The data processing circuitry performs control such that the analytical data is generated in a first measurement section if it is determined that continuation of the reaction of the solution mixture is unnecessary, and the analytical data is generated by measuring the solution mixture after the first measurement section if it is determined that continuation of the reaction of the solution mixture is necessary.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 28, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Asuka Uchikawa, Shoichi Kanayama
  • Patent number: 10632464
    Abstract: A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 28, 2020
    Assignee: ALERE SAN DIEGO, INC.
    Inventors: Alexander Schenk zu Schweinsberg, Austin Matthew Derfus, Justin Davidson, Karthikeyan Kumaravadivelu, Maulik Vinod Patel, Olaf Piepenburg, Catherine Jean Greenwood, Oliver Nentwich
  • Patent number: 10613109
    Abstract: The objective of this disclosure is to provide a dispensing apparatus that is capable of precisely dispense micro volume liquid samples without physically damaging the nozzle tip or the liquid containers. An example of the present disclosure images a droplet of a liquid sample, and dispenses the liquid sample using an image of the droplet.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 7, 2020
    Assignee: HITACHI, LTD.
    Inventor: Takahiro Ando
  • Patent number: 10584383
    Abstract: The present invention relates to a method for predicting mortality of a test patient with chronic heart failure comprising based on detecting the expression level of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 8. The present invention also relates to a method for predicting cardiac remodeling after myocardial infarction in a test patient based on detecting the expression level of one or more lncRNAs selected from SEQ ID NOs 1 to 8.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: March 10, 2020
    Assignees: MEDIZINISCHE HOCHSCHULE HANNOVER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITÉ DE LILLE 2 (LILLE 2)—UNIVERSITY OF LAW AND HEALTH, CENTRE HOSPITALIER UNIVERSITAIRE LILLE (CHU), INSTITUT PASTEUR DE LILLE (IPL)
    Inventors: Thomas Thum, Regalla Kumarswamy, Florence Pinet, Christophe Bauters, Pascal De Groote
  • Patent number: 10526659
    Abstract: Biomarkers and methods related to microbiota for predicting the risk of a disease, particularly colorectal cancer (CRC), are described.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: January 7, 2020
    Assignees: BGI Shenzhen Co., Limited, BGI Shenzhen
    Inventors: Qiang Feng, Dongya Zhang, Longqing Tang, Jun Wang
  • Patent number: 10514350
    Abstract: An apparatus and method may operate to mount an electrode assembly with the exterior of a casing string to be placed in a borehole in a subterranean formation. The electrode assembly may include electrodes in spaced relation to one another. After the casing string and associated electrode assembly are in the borehole, the method may include providing a series of excitation signals at a plurality of frequencies to at least one electrode to inject a series of injection signals into fluid in the annulus. The method can further include receiving signals in response to the series of injection signals through at least one other electrode. The received signals can be representative of an impedance spectrum including impedance values representative of the fluid in the borehole annulus. The method can further include identifying the fluid in reference to the impedance spectrum. Additional apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: December 24, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Peter James Boul, Randal Thomas Beste, Jesse Kevin Hensarling, Krishna M. Ravi
  • Patent number: 10359354
    Abstract: The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 23, 2019
    Assignee: AZURE BIOSYSTEMS, INC.
    Inventors: Michel Fortin, Alain Chandonnet, Dany Nolet
  • Patent number: 10335786
    Abstract: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening in the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path. The seal may be configured to temporarily obstruct flow through at least a portion of the flow path. The seal may also be configured to open in response to a force exerted via a capillary tube inserted into the at least one opening.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: July 2, 2019
    Assignee: Pixcell Medical Technologies Ltd.
    Inventors: Avishay Bransky, Liron Shiomo
  • Patent number: 10292534
    Abstract: A food container assembly includes a housing with a bottom wall and a perimeter wall that is attached to and extends upwardly therefrom. The perimeter wall has an upper edge defining an access opening into the housing. A shoulder is attached to an inner surface of the perimeter wall and extends continuously around an interior of the housing. The shoulder is spaced from the upper edge. A food holder is removably positioned in the housing and comprises a mesh material such that fluids may flow through the food holder. The food holder has an outer ridge that releasably engages the shoulder to support the food holder on the shoulder so that the food holder is spaced from the bottom wall.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: May 21, 2019
    Inventor: Frederick Fox, III
  • Patent number: 10260099
    Abstract: Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 16, 2019
    Inventors: Antonio V. Delgado-Escueta, Kazuhiro Yamakawa, Toshimitsu Suzuki, Marco Tulio Medina-Hernandez, Maria Elisa Alonso Vilatela
  • Patent number: 10245585
    Abstract: A specimen processing apparatus includes a housing having a fluid supply reservoir, a specimen receiving chamber, a specimen collection reservoir, and an actuator coupled to the fluid supply reservoir. A liquid flow path extends from the fluid supply reservoir to the specimen receiving chamber, and to the specimen collection reservoir. The actuator is operable to propel a liquid from the fluid supply reservoir to the chamber. The specimen receiving chamber includes an inlet port, an outlet port, and a fluid flow guide disposed between the inlet port and the outlet port. In addition, the fluid supply reservoir is fluidly coupled to the inlet port and the outlet port is fluidly coupled to the specimen collection reservoir. The fluid flow guide may be operable to roil a liquid as it flows from the inlet port to the outlet port to facilitate the extraction of a specimen from a collection device.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: April 2, 2019
    Assignee: PARATUS DIAGNOSTICS, LLC
    Inventors: John C. Carrano, Roland Schneider, John J. Carrano
  • Patent number: 10202638
    Abstract: The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: February 12, 2019
    Assignee: DAKO DENMARK A/S
    Inventor: Steen Hauge Matthiesen
  • Patent number: 10184884
    Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: January 22, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Nicholas Anderson, Jeffery Debad, Eli N. Glezar, Sudeep Kumar, Noel Lawrence, Kenneth Page, George Sigal, Sharon West
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10034738
    Abstract: Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: July 31, 2018
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Nimalan Thavandiran, Milica Radisic, Peter Zandstra
  • Patent number: 10031144
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: July 24, 2018
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
  • Patent number: 10016738
    Abstract: Horizontal reactor (1) for catalytic reactions, comprising an outer cylindrical shell (2), a catalytic bed (5) and heat exchange plates (6) immersed in said catalytic bed, parallel to each other and supplied with a heat exchange fluid; said reactor comprises a container (7) for said catalytic bed (5) and said plates (6), said container is extractable slidably from said shell, by means of at least one linear guide (31, 32, 45) extended longitudinally with respect to said shell (2).
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 10, 2018
    Assignee: Casale SA
    Inventors: Ermanno Filippi, Enrico Rizzi
  • Patent number: 9999706
    Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: June 19, 2018
    Assignee: NOBIL BIO RICERCHE S.R.L.
    Inventors: Daniele Bollati, Marco Morra, Clara Cassinelli, Giovanna Cascardo
  • Patent number: 9999685
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO: 1 or a nucleic acid sequence of at least 200 bp having at least 70% identity to the sequence of SEQ ID NO: 1, wherein the isolated nucleic acid molecule specifically leads to the expression in retinal amacrine bipolar cells of a gene when operatively linked to a nucleic acid sequence coding for the gene.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 19, 2018
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Botond Roska, Josephine Juettner
  • Patent number: 9945883
    Abstract: A pipetting system includes a rail; a carriage to engage the rail, the carriage movable relative to the rail substantially along a first axis; a pipette pump slidably engaged with the carriage, the pipette pump slidable relative to the carriage substantially along the first axis; and a sensor to detect movement of the pipette pump relative to the carriage.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: April 17, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventor: Nathan Kane
  • Patent number: 9924929
    Abstract: The present invention relates to a kit for taking biopsies, resections, excisions, and/or autopsies. Moreover, the present invention relates to methods of taking biopsies resections, excisions, and/or autopsies using the kit of the present invention. The kits and methods of the present invention allow for fewer errors, decreased turn around time and/or more rapid processing due to a cassette and specimen numbering system that is simplified and superior over that which has been previously disclosed in the prior art. The kit of the present invention comprises one or more tissue cassettes, and optionally one or more bottles of formalin and optionally, other components.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: March 27, 2018
    Assignee: Metamark Laboratories, Inc.
    Inventors: David L. Booker, Stephen Mark Repko, Kimberly A. Grice
  • Patent number: 9889447
    Abstract: Provided are a reagent supply method and device capable of using up a reagent in a container without a remnant to the extent possible, and supplying the reagent to an analysis device without mixing air bubbles even when the remaining amount of the reagent is extremely small. The reagent supply device includes: at least one reagent container including: a container body for storing a liquid reagent; and a reagent supply port arranged on the container body; and a support member for supporting the at least one reagent container so that the reagent supply port is positioned on a lower side of the container body. The reagent supply port is sealed by a plug including at least one nozzle penetration portion. The at least one nozzle penetration portion is formed of a material having a Shore hardness of from A5° to A90°.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 13, 2018
    Assignees: SEKISUI MEDICAL CO. , LTD., SEKISUI TECHNO MOLDING CO. , LTD.
    Inventors: Yuriko Nemoto, Hiroaki Taira, Takuya Yotani, Satoru Tominaga
  • Patent number: 9891147
    Abstract: The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 13, 2018
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Daniel Lapen, David Zahniser, Mark Licari, Brian J. McKeen, Eric D. Yeaton, Dennis Poole, Stephen Conroy
  • Patent number: 9873119
    Abstract: Provided herein are systems and methods for performing complex chemical, physical and biological assays. In particular, provided herein are systems and methods for performing microfluidic assays.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: January 23, 2018
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Mark W. Eshoo, John Picuri
  • Patent number: 9868990
    Abstract: The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NIPA-1 proteins.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: January 16, 2018
    Assignees: The Regents of the University of Michigan, The Trustees of the University of Pennsylvania
    Inventors: John K. Fink, Shirley Rainier, Robert D. Nicholls, Jinghua Chai
  • Patent number: 9858660
    Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: January 2, 2018
    Assignee: Theranos, Inc.
    Inventor: Elizabeth A. Holmes
  • Patent number: 9821305
    Abstract: The invention relates to a pipetting device for automatic analysis instruments and a method for heating a volume of liquid in a heated pipetting needle.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: November 21, 2017
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Thorsten Michels, Ayhan Selvi, Alexander Wiedekind-Klein
  • Patent number: 9809860
    Abstract: This invention relates to test kits and methods for their use in determining the expression levels of genetic markers. Additionally, this invention relates to kits and uses thereof for the determination of ratios of genetic markers. Ratios of genetic markers can be used to assist in analysis of bladder cancer from samples of urine.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: November 7, 2017
    Assignee: Pacific Edge Limited
    Inventor: Parry John Guilford
  • Patent number: 9776182
    Abstract: Devices, systems and methods for making and handling liquid samples are disclosed.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 3, 2017
    Assignee: GenCell Biosystems Ltd.
    Inventors: Kieran Curran, David McGuire, Brian Chawke, Paul Fleming, Brian Barrett, Noel Sirr
  • Patent number: 9778200
    Abstract: A method is provided for a portable computing device to read a reaction area on a test strip, which is located in a peripheral device placed over an image sensor and a light source of the portable computing device. Light is provided with the light source, which the peripheral device directs to the reaction area. An image including the reaction area is captured with the image sensor. An analyte characteristic is determined based on a color of the captured reaction area in the image.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: October 3, 2017
    Assignee: IXENSOR CO., LTD.
    Inventors: Tungmeng Tsai, Yenyu Chen, Chieh Hsiao Chen
  • Patent number: 9778274
    Abstract: An automatic analyzer having no limitation on a range of a placeable position on a sample placement disk for patient specimens, emergency specimens, quality control samples, and calibration samples, and being capable of performing analysis while changing the number of simultaneously-measurable samples for each type of each specimen is provided. In the automatic analyzer, either a calibration sample dedicated disk or a patient specimen dedicated disk is placed in an analyzing unit 8 as a sample placement disk 19, and the analyzing unit 8 has a disk identifying unit 24 which identifies a type of the sample placement disk 19, and a computer 22 identifies the type of the sample placement disk 19 based on an identification result of the disk identifying unit 24, and performs analysis on a liquid sample based on the identified type of the sample placement disk 19.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: October 3, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takao Shiba, Yoshiyuki Tanaka, Eiichi Matsubara
  • Patent number: 9759640
    Abstract: An embodiment of the claimed invention is directed to a method that greatly streamlines and reduces costs for tissue preparation, preservation, long-term storage and sample retrieval for molecular analysis using a method based on dried blood spot (DBS) technology. In this method, a small needle punch sample of freshly excised tissue will be homogenized in stabilizing reagent and inserted into a device containing absorbent material and drying agent. This device is suitable for long-term sample storage at ambient temperature and allows for easy removal of sections for biomarker analysis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 12, 2017
    Assignee: Spot on Sciences, Inc.
    Inventors: James Hill, Jeanette Hill
  • Patent number: 9702009
    Abstract: This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumor marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio, regression or classification analysis of the expression levels of at least one under-expressed TM, particularly an under-expressed bladder TM (BTM), and at least one over-expressed TM, particularly an over-expressed BTM. In various aspects, the invention relates to kits and devices for carrying out these methods.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: July 11, 2017
    Assignee: PACIFIC EDGE LIMITED
    Inventor: Parry John Guilford
  • Patent number: 9604215
    Abstract: This invention relates to the design, construction and method of use of a novel thin film transport and applicator for use on XRF sample cups.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: March 28, 2017
    Assignee: Premier Lab Supply Inc.
    Inventor: Donato Pompa
  • Patent number: 9597612
    Abstract: Provided is an analyzer performing solid-phase extraction of a measurement component (i.e., component to be measured) in a sample solution while decreasing an amount of waste generated and reducing a running cost. The analyzer includes: a solid-phase extraction container having a body part to receive a sample solution containing a measurement component of analytical target and a discharge passage to discharge the sample solution. Herein, the discharge passage is to be filled with a solid-phase extraction material for subjecting the measurement component to solid-phase extraction.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: March 21, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Tadao Yabuhara, Izumi Waki
  • Patent number: 9593384
    Abstract: The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: March 14, 2017
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: David W Hilbert, Scott E Gygax, Martin E. Adelson, Eli Mordechai, Jessica Schuyler, Teresa Paulish-Miller
  • Patent number: 9518902
    Abstract: An embedder is provided. The embedder includes a body having a working stand; a paraffin reservoir disposed in the body; a paraffin dispenser disposed on the body and connected with the paraffin reservoir; a heated working plate disposed on the working stand; a cooling plate disposed on the working stand; a tray disposed on the working stand; and a ceramic layer at least formed on an inner wall surface of the tray. With the embedder according to the present invention, by coating the ceramic layer on the inner wall surface of the tray to form an anti-scratch protective layer, when removing solidified paraffin wax on the inner wall surface of the tray, it is possible to avoid scratching the inner wall surface of the tray so as to avoid the damage to the surface of the tray.
    Type: Grant
    Filed: November 28, 2015
    Date of Patent: December 13, 2016
    Assignee: Leica Microsystems Ltd. Shanghai
    Inventors: Ningjiang Chen, Yuan Chu, Chonglu Wang
  • Patent number: 9476806
    Abstract: A sample processing system includes a sample vessel holder including a disk-shaped base section disposed so as to have a central axis extending in a vertical direction and a sample vessel holding section that is formed coaxially with, and above, the base section for holding a sample vessel in an upright posture. A conveyor conveys the sample vessel holder 1 placed thereon; and a holding plate is disposed so as to extend along an outer peripheral portion of a columnar space that has a central axis extending in the vertical direction, and is disposed at a position above a space past which the base section of the sample vessel holder moves along the conveyor and at a position past which at least the sample vessel holding section moves. This enables individual conveyance processing to be performed for each of multiple sample vessels.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: October 25, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshiteru Hirama, Hiroshi Ohga, Tatsuya Fukugaki, Hiroaki Sakai, Kazuma Tamura
  • Patent number: 9459219
    Abstract: A sample temperature control chamber is described for a benchtop X-ray machine and/or full-protection X-ray machine, which comprises (a) a first chamber part (11) and a second chamber part (12) which can be connected together and are configured so as to form a closed chamber, (b) a sample holder, (c) an integrated temperature control device for controlling the temperature of a sample (P) which is provided on the sample holder, and (d) an active cooling system for dissipating heat from the sample temperature control chamber, the active cooling system comprising a heat sink and/or a fan. A system for X-ray-based analysis of a sample, in particular for X-ray diffraction measurements, is also described.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: October 4, 2016
    Assignee: Anton Paar GmbH
    Inventors: Josef Gautsch, Christian Resch
  • Patent number: 9459189
    Abstract: A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: October 4, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Scott M. Berry, David J. Guckenberger, Ben P. Casavant
  • Patent number: 9446411
    Abstract: A sample presentation apparatus comprises a round support movable in an optical assembly and having a flange region and an elevated gear shaped region having indexing gear cogs at intermediate radius locations of the support; a sample carrier slide holder removably supported on and movable with the support, the slide holder having at least one arm extending radially from a central hub of the sample carrier slide holder and being aligned between a first pair of indexing gear cogs; and at least one sample carrier slide removably supported on the support and aligned by the first pair of indexing gear cogs. In another embodiment of the invention, a self-aligning movable platform and support apparatus in an optical assembly comprises coarse and fine alignment mechanisms.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 20, 2016
    Assignee: REAMETRIX, INC.
    Inventors: Bala S. Manian, Pramod Kummaya