Container Patents (Class 422/547)
  • Patent number: 11414703
    Abstract: Disclosed are nucleic acid molecules from the genome of Dirofilaria spp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species of Dirofilaria is Dirofilaria immitis (the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with a Dirofilaria spp. nematode, and kits for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: August 16, 2022
    Assignees: Elanco US Inc.
    Inventors: Roger K. Prichard, Catherine Bourguinat, Timothy G. Geary
  • Patent number: 11399811
    Abstract: The present invention relates in general to the improved containment of biological fluids. In particular, a method and apparatus for collection and preservation of fluid samples in accordance with the present invention results in collection of semen having improved viability both at the time of collection and after storage. The disclosed methods and apparatuses methods support a wide variety of applications for containment of biological fluids related to human and veterinary medicine including, but not limited to, human reproductive medicine and animal husbandry.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: August 2, 2022
    Assignees: TEXAS TECH UNIVERSITY SYSTEM, RSI TECHNOLOGY GROUP, LLC
    Inventors: Samuel D. Prien, Lindsay L. Penrose, Diana M. Peninger
  • Patent number: 11389798
    Abstract: Infectious diseases have been sources of large-scale epidemics and pandemics resulting in millions of casualties worldwide. Detection of these biological agents normally involves several lab processes including sample preparation, nucleic acid separation and amplification, and diagnostic analysis. These steps, either performed manually or automated by high-throughput machinery, are tedious, expensive, and highly susceptible to cross-contamination. The present system is an integrated lab-on-a-device designed, developed, and tested in compatibility with a mechanical fixture for sample-to-answer biological analysis of infectious diseases.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: July 19, 2022
    Assignee: CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE
    Inventors: Benjamin Liu, Eva McGhee, Robin Liu, Miguel Nava
  • Patent number: 11334396
    Abstract: Host specific containerized application configuration generation is disclosed. For example, first and second image files are stored on a first memory. Second and third memories are associated with a first host node. A request to generate a first configuration file associated with a plurality of isolated guests is received, launching a first short-lived guest of the plurality of isolated guests on the second memory. A configuration management application executes on the first short-lived guest, generating and saving the first configuration file to the third memory. The first short-lived guest is terminated. A first service guest of the plurality of isolated guests is launched on the second memory. A first service configured with the first configuration file executes on the first service guest. A second service guest of the plurality of isolated guests is launched on the second memory executing a second service configured with the first configuration file.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: May 17, 2022
    Assignee: Red Hat, Inc.
    Inventors: Paul Daniel Prince, Martin Nicolas Andre, Flavio Percoco, Ian Main
  • Patent number: 11275075
    Abstract: Collection systems for flow cytometrically sorted samples are provided. Aspects of the collection systems include: a collection container having a sort tube configured to be in droplet receiving relationship with a sort block of a flow cytometer; and a sample output operatively coupling a cell collection location of the collection container to a mating connection for a receiving container, such as an evacuated receiving container. Also provided are methods using the collection systems, as well as assemblies and kits including components of the systems.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: March 15, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventor: Kyle Dembski
  • Patent number: 11275076
    Abstract: A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 15, 2022
    Assignee: Medtronic, Inc.
    Inventors: Charlene Yuan, Trevor Huang, Tessy Kanayinkal
  • Patent number: 11235334
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: February 1, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
  • Patent number: 11204314
    Abstract: A calibration data acquisition unit (a) acquires Q optical spectra, S evaluation spectra, and a reference spectrum of a target component, (b) extracts R subsets from a set of the optical spectra, (c) performs independent component analysis in which component amounts are treated as independent components on each subset so as to acquire component natural spectra and component calibration spectra, (d) obtains an inner product value between the component calibration spectrum and the evaluation spectrum, (e) obtains a correlation degree between a component amount for the target component and the inner product value with respect to each component calibration spectrum, (f) obtains a similarity between each component natural spectrum and a reference spectrum, (g) selects a component calibration spectrum causing a comprehensive evaluation value based on the correlation degree and the similarity to be greatest as the target component calibration spectrum, and (h) creates a calibration curve.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: December 21, 2021
    Inventor: Hikaru Kurasawa
  • Patent number: 11119048
    Abstract: A highly integrated, fully automatic chemiluminescence detection equipment and its operation method are disclosed. The chemiluminescence detection equipment comprises a control module, a first electrical machine, a reagent wheel disc tank, a sampling module, a washing module, a second electrical machine and a detection module. Compared with the traditional large-scale chemiluminescence detection equipment, the chemiluminescence detection equipment of the present invention has the advantage of high integration, and greatly reduces the overall volume and weight of the chemiluminescence detection equipment.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: September 14, 2021
    Assignee: SHAOXING PUSHKANG BIOTECHNOLOGY CO., LTD.
    Inventors: Lin Cheng, Chun-Yan Liu, Ya-Xiong Zhang, Xi-Jiang Qian, Quan-Qi Yang, Xian-Hua Wang, Hui Xu, Bo Yu, Ye-Qi Jin
  • Patent number: 11085082
    Abstract: Provided is a method of assessing Gestational Diabetes Mellitus (GDM) susceptibility in a female human subject, the method comprising determining the identity of at least one allele at each of at least two positions of single nucleotide polymorphism (SNP) selected from: TCF7L2—rs7903146; IGF2BP2—rs4402960; CDKN2A/B—rs10811661; SLC16A11—rs13342232; FTO—rs8050136; SLC30A8—rs13266634; CDC123/CAMK1D—rs12779790; KCNQ1—rs2237892; CUBN—rs11254363; CUBN—rs1801222; FIGN—rs2119289; FIGN—rs982393; MTHFR—rs1801131; MTHFR—rs1801133; MTR—rs1805087; and SLC19A1—rs1051266, and/or an SNP in linkage disequilibrium therewith at r2>0.8. Also provided are genotyping tools and risk assessment systems for use in the method of assessing GDM susceptibility.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 10, 2021
    Assignee: Patia Biopharma S.A. de C.V.
    Inventors: Laureano Simón Buela, Mirella G. Zulueta, Teresa Tusié
  • Patent number: 11072813
    Abstract: Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 27, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Bart Edward Gusta Jozef Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek Unay, Roel Penterman, Paul Arnold Van De Wiel
  • Patent number: 11053469
    Abstract: Provided is a culture bag accommodating a culture fluid, the culture bag is capable of suppressing foaming in the culture fluid when oscillating the culture fluid to perform a culture, and performing a culture with high efficiency. The culture bag includes a culture space accommodating a culture fluid, the culture space being an endless space to allow the culture fluid to circulate therein, in which the culture bag has an inner surface that comes into contact with the culture fluid to be accommodated therein, the inner surface including, at least in part thereof, a concave-convex region having a concave-convex structure.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 6, 2021
    Assignee: Dexerials Corporation
    Inventors: Hirokazu Odagiri, Yasuyuki Kudo, Rishabh Gupta, Keiji Honjo
  • Patent number: 11051609
    Abstract: An oral cleaning device (10) for characterizing a position of a brush head of the device. The oral cleaning device includes: a body portion (12); a brush head (14) extending from the body portion, where at least a portion of the brush head is configured to move relative to the body portion; a controller (30); and an optical sensor (28) positioned relative to the brush head member and body portion and being in communication with the controller, where the optical sensor is configured to obtain optical sensor data resulting from a deflection or rotation of the brush head member relative to the body portion; the controller being configured to receive the optical sensor data and determine the deflection or rotation of the brush head member relative to the body portion.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: July 6, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Stijn Willem Boere, Aditya Mehendale
  • Patent number: 11053037
    Abstract: A medical vial filling system is adapted to fill a medical vial with a solution and cap the filled medical vial. A purging system includes a manifold disposed between a filling station and a capping station. The manifold includes a filling inlet port and a plurality of output ports. The output ports are positioned in a space proximate the filling station and in a space over the transport mechanism. A stoppering block includes a capping chamber for receiving a bushing positioned at the capping station. The stoppering block comprises a stoppering inlet port, a first nozzle opening into the capping chamber and a second nozzle extending into the capping chamber and directed into the medical vial when the medical vial is position in the capping station.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: July 6, 2021
    Assignee: HIKMA PHARMACEUTICALS USA INC.
    Inventors: Simon Freed, David C. Woodruff
  • Patent number: 11041750
    Abstract: A laboratory weighing kit comprises two layers: a disposable paper-structured weighing boat in the upper layer and a corresponding-shaped weighing base in the lower layer. The weighing boat has a sample loading portion in the rear to carry chemicals or samples, and a funnel portion in the front to transfer samples. In order to consolidate storage space, either the front funnel can be opened to two portions or the back wall of the weighing boat is opened. The weighing boat can be creased to form a permanent fold. The weighing boat in the upper layer can be either removable from or permanently attached to the weighing base in the lower layer.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: June 22, 2021
    Assignee: CHEMRUS INC.
    Inventors: Jianjian Cai, Xiaogao Liu
  • Patent number: 10948508
    Abstract: A transport device unit for a transport device assembled using a plurality of transport device units is presented. The transport device unit comprises a base plate module with a base plate for fixing the transport device unit to a support frame, an actuator module with a plurality of electro-magnetic actuators, where the actuator module is supported by the base plate module, and a driving surface module with a driving surface element, where the driving surface element is arranged above the actuator module covering the actuators and configured to carry sample container carriers. A transport device, a system for at least partially disassembling the transport device, and a laboratory sample distribution system comprising a transport device are also presented. In addition, a laboratory automation system comprising a laboratory sample distribution system is also presented.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: March 16, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans Schneider, Eugen Lusser, Marcel Kaeppeli, Tobias Huber, Hermann Pius, Matthias Edelmann
  • Patent number: 10766031
    Abstract: The present disclosure relates to a microfluidic-based analyzer, including a drive module and a microfluidic disc. On the microfluidic disk, a capillary is connected between a mixing chamber and a waste chamber. More particularly, the capillary is connected to the mixing chamber through a first access on the first radius of the microfluidic disc, and the capillary is connected to the waste chamber through a second access on the second radius of the microfluidic disk. Specifically, a turn of the capillary is disposed between the first access and the second access, in which a folding is configured on a third radius of the microfluidic disc. Overall, the aforementioned microfluidic-based analyzer is able to be operated in different rotational speeds and is capable of evacuating the mixing chamber and enhancing the washing efficiency.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: September 8, 2020
    Assignee: FENG CHIA UNIVERSITY
    Inventors: Chih-Hsin Shih, Ho-Chin Wu, Yen-Hao Chen
  • Patent number: 10758211
    Abstract: A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container includes an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: September 1, 2020
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Timothy R. Hansen, Mark Talmer, Kevin Bailey, Dwight Livingston
  • Patent number: 10739358
    Abstract: Portable coagulation monitoring devices, systems, and methods are disclosed. Namely, a test cartridge is provided for use in a portable coagulation monitor (PCM) device. Further, the test cartridge comprises two glass-filled thermoplastic polymer plates and a disposable blood introduction device. The two glass-filled thermoplastic polymer plates are arranged substantially in parallel with a small gap therebetween for receiving a sample of blood to be tested. Using the PCM device, the two glass-filled thermoplastic polymer plates can be moved linearly relative to each other. Methods of measuring coagulation response in a blood sample using the test cartridge and the PCM device are provided. A method of introducing blood into the test cartridge using the disposable blood introduction device is provided.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 11, 2020
    Assignee: ENTEGRION, INC.
    Inventors: Matthew Pearce, Richard Hall, Joseph Anthony Dacorta
  • Patent number: 10717087
    Abstract: Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: July 21, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Yoshihiro Suzuki
  • Patent number: 10712244
    Abstract: Provided is a specimen staining apparatus that includes a gap-forming member arranged to form a gap having a thickness that induces capillary action, the gap being formed above a mounting surface of a slide glass having a specimen mounted thereon; and a chemical solution supply unit that supplies a chemical solution for staining the specimen to the gap between the gap-forming member and the mounting surface so that the chemical solution spreads within the gap due to capillary action and is evenly supplied to the specimen placed on the mounting surface.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 14, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Yoshihiro Kawano, Kei Tsuyuki, Asuka Yamamoto
  • Patent number: 10688458
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 23, 2020
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
  • Patent number: 10688209
    Abstract: A system includes a radiation containment chamber, an isolator connected to the radiation containment chamber, a rotating transfer door positioned between the radiation containment chamber and the isolator, and an antimicrobial vapor generator connected to the isolator. The rotating transfer door includes a cavity for receiving a radionuclide generator column assembly, and is rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator. The transfer door is adapted to rotate while antimicrobial vapor is introduced into the isolator by the antimicrobial vapor generator.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 23, 2020
    Assignee: Curium US LLC
    Inventors: John Schmitz, Michael J. D'Hooge, Andrew M. Schadt, Gregory Bengard, Sumit Verma, Kevin B. Graves, Bryan S. Petrofsky
  • Patent number: 10662485
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 26, 2020
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Patent number: 10634690
    Abstract: According to one embodiment, there is provided an automatic analyzing apparatus which comprises determination processing circuitry, an analyzer mechanism and data processing circuitry. The determination processing circuitry determines whether to continue reaction of a solution mixture based on reaction data. The analyzer mechanism generates analytical data based on test data generated by measuring the solution mixture. The data processing circuitry performs control such that the analytical data is generated in a first measurement section if it is determined that continuation of the reaction of the solution mixture is unnecessary, and the analytical data is generated by measuring the solution mixture after the first measurement section if it is determined that continuation of the reaction of the solution mixture is necessary.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 28, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Asuka Uchikawa, Shoichi Kanayama
  • Patent number: 10632464
    Abstract: A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 28, 2020
    Assignee: ALERE SAN DIEGO, INC.
    Inventors: Alexander Schenk zu Schweinsberg, Austin Matthew Derfus, Justin Davidson, Karthikeyan Kumaravadivelu, Maulik Vinod Patel, Olaf Piepenburg, Catherine Jean Greenwood, Oliver Nentwich
  • Patent number: 10613109
    Abstract: The objective of this disclosure is to provide a dispensing apparatus that is capable of precisely dispense micro volume liquid samples without physically damaging the nozzle tip or the liquid containers. An example of the present disclosure images a droplet of a liquid sample, and dispenses the liquid sample using an image of the droplet.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 7, 2020
    Assignee: HITACHI, LTD.
    Inventor: Takahiro Ando
  • Patent number: 10584383
    Abstract: The present invention relates to a method for predicting mortality of a test patient with chronic heart failure comprising based on detecting the expression level of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 8. The present invention also relates to a method for predicting cardiac remodeling after myocardial infarction in a test patient based on detecting the expression level of one or more lncRNAs selected from SEQ ID NOs 1 to 8.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: March 10, 2020
    Assignees: MEDIZINISCHE HOCHSCHULE HANNOVER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITÉ DE LILLE 2 (LILLE 2)—UNIVERSITY OF LAW AND HEALTH, CENTRE HOSPITALIER UNIVERSITAIRE LILLE (CHU), INSTITUT PASTEUR DE LILLE (IPL)
    Inventors: Thomas Thum, Regalla Kumarswamy, Florence Pinet, Christophe Bauters, Pascal De Groote
  • Patent number: 10526659
    Abstract: Biomarkers and methods related to microbiota for predicting the risk of a disease, particularly colorectal cancer (CRC), are described.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: January 7, 2020
    Assignees: BGI Shenzhen Co., Limited, BGI Shenzhen
    Inventors: Qiang Feng, Dongya Zhang, Longqing Tang, Jun Wang
  • Patent number: 10514350
    Abstract: An apparatus and method may operate to mount an electrode assembly with the exterior of a casing string to be placed in a borehole in a subterranean formation. The electrode assembly may include electrodes in spaced relation to one another. After the casing string and associated electrode assembly are in the borehole, the method may include providing a series of excitation signals at a plurality of frequencies to at least one electrode to inject a series of injection signals into fluid in the annulus. The method can further include receiving signals in response to the series of injection signals through at least one other electrode. The received signals can be representative of an impedance spectrum including impedance values representative of the fluid in the borehole annulus. The method can further include identifying the fluid in reference to the impedance spectrum. Additional apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: December 24, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Peter James Boul, Randal Thomas Beste, Jesse Kevin Hensarling, Krishna M. Ravi
  • Patent number: 10359354
    Abstract: The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 23, 2019
    Assignee: AZURE BIOSYSTEMS, INC.
    Inventors: Michel Fortin, Alain Chandonnet, Dany Nolet
  • Patent number: 10335786
    Abstract: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening in the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path. The seal may be configured to temporarily obstruct flow through at least a portion of the flow path. The seal may also be configured to open in response to a force exerted via a capillary tube inserted into the at least one opening.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: July 2, 2019
    Assignee: Pixcell Medical Technologies Ltd.
    Inventors: Avishay Bransky, Liron Shiomo
  • Patent number: 10292534
    Abstract: A food container assembly includes a housing with a bottom wall and a perimeter wall that is attached to and extends upwardly therefrom. The perimeter wall has an upper edge defining an access opening into the housing. A shoulder is attached to an inner surface of the perimeter wall and extends continuously around an interior of the housing. The shoulder is spaced from the upper edge. A food holder is removably positioned in the housing and comprises a mesh material such that fluids may flow through the food holder. The food holder has an outer ridge that releasably engages the shoulder to support the food holder on the shoulder so that the food holder is spaced from the bottom wall.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: May 21, 2019
    Inventor: Frederick Fox, III
  • Patent number: 10260099
    Abstract: Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 16, 2019
    Inventors: Antonio V. Delgado-Escueta, Kazuhiro Yamakawa, Toshimitsu Suzuki, Marco Tulio Medina-Hernandez, Maria Elisa Alonso Vilatela
  • Patent number: 10245585
    Abstract: A specimen processing apparatus includes a housing having a fluid supply reservoir, a specimen receiving chamber, a specimen collection reservoir, and an actuator coupled to the fluid supply reservoir. A liquid flow path extends from the fluid supply reservoir to the specimen receiving chamber, and to the specimen collection reservoir. The actuator is operable to propel a liquid from the fluid supply reservoir to the chamber. The specimen receiving chamber includes an inlet port, an outlet port, and a fluid flow guide disposed between the inlet port and the outlet port. In addition, the fluid supply reservoir is fluidly coupled to the inlet port and the outlet port is fluidly coupled to the specimen collection reservoir. The fluid flow guide may be operable to roil a liquid as it flows from the inlet port to the outlet port to facilitate the extraction of a specimen from a collection device.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: April 2, 2019
    Assignee: PARATUS DIAGNOSTICS, LLC
    Inventors: John C. Carrano, Roland Schneider, John J. Carrano
  • Patent number: 10202638
    Abstract: The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: February 12, 2019
    Assignee: DAKO DENMARK A/S
    Inventor: Steen Hauge Matthiesen
  • Patent number: 10184884
    Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: January 22, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Nicholas Anderson, Jeffery Debad, Eli N. Glezar, Sudeep Kumar, Noel Lawrence, Kenneth Page, George Sigal, Sharon West
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10034738
    Abstract: Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: July 31, 2018
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Nimalan Thavandiran, Milica Radisic, Peter Zandstra
  • Patent number: 10031144
    Abstract: Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: July 24, 2018
    Assignee: HemoSonics LLC
    Inventors: Francesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
  • Patent number: 10016738
    Abstract: Horizontal reactor (1) for catalytic reactions, comprising an outer cylindrical shell (2), a catalytic bed (5) and heat exchange plates (6) immersed in said catalytic bed, parallel to each other and supplied with a heat exchange fluid; said reactor comprises a container (7) for said catalytic bed (5) and said plates (6), said container is extractable slidably from said shell, by means of at least one linear guide (31, 32, 45) extended longitudinally with respect to said shell (2).
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 10, 2018
    Assignee: Casale SA
    Inventors: Ermanno Filippi, Enrico Rizzi
  • Patent number: 9999685
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO: 1 or a nucleic acid sequence of at least 200 bp having at least 70% identity to the sequence of SEQ ID NO: 1, wherein the isolated nucleic acid molecule specifically leads to the expression in retinal amacrine bipolar cells of a gene when operatively linked to a nucleic acid sequence coding for the gene.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 19, 2018
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Botond Roska, Josephine Juettner
  • Patent number: 9999706
    Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: June 19, 2018
    Assignee: NOBIL BIO RICERCHE S.R.L.
    Inventors: Daniele Bollati, Marco Morra, Clara Cassinelli, Giovanna Cascardo
  • Patent number: 9945883
    Abstract: A pipetting system includes a rail; a carriage to engage the rail, the carriage movable relative to the rail substantially along a first axis; a pipette pump slidably engaged with the carriage, the pipette pump slidable relative to the carriage substantially along the first axis; and a sensor to detect movement of the pipette pump relative to the carriage.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: April 17, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventor: Nathan Kane
  • Patent number: 9924929
    Abstract: The present invention relates to a kit for taking biopsies, resections, excisions, and/or autopsies. Moreover, the present invention relates to methods of taking biopsies resections, excisions, and/or autopsies using the kit of the present invention. The kits and methods of the present invention allow for fewer errors, decreased turn around time and/or more rapid processing due to a cassette and specimen numbering system that is simplified and superior over that which has been previously disclosed in the prior art. The kit of the present invention comprises one or more tissue cassettes, and optionally one or more bottles of formalin and optionally, other components.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: March 27, 2018
    Assignee: Metamark Laboratories, Inc.
    Inventors: David L. Booker, Stephen Mark Repko, Kimberly A. Grice
  • Patent number: 9889447
    Abstract: Provided are a reagent supply method and device capable of using up a reagent in a container without a remnant to the extent possible, and supplying the reagent to an analysis device without mixing air bubbles even when the remaining amount of the reagent is extremely small. The reagent supply device includes: at least one reagent container including: a container body for storing a liquid reagent; and a reagent supply port arranged on the container body; and a support member for supporting the at least one reagent container so that the reagent supply port is positioned on a lower side of the container body. The reagent supply port is sealed by a plug including at least one nozzle penetration portion. The at least one nozzle penetration portion is formed of a material having a Shore hardness of from A5° to A90°.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 13, 2018
    Assignees: SEKISUI MEDICAL CO. , LTD., SEKISUI TECHNO MOLDING CO. , LTD.
    Inventors: Yuriko Nemoto, Hiroaki Taira, Takuya Yotani, Satoru Tominaga
  • Patent number: 9891147
    Abstract: The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 13, 2018
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Daniel Lapen, David Zahniser, Mark Licari, Brian J. McKeen, Eric D. Yeaton, Dennis Poole, Stephen Conroy
  • Patent number: 9873119
    Abstract: Provided herein are systems and methods for performing complex chemical, physical and biological assays. In particular, provided herein are systems and methods for performing microfluidic assays.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: January 23, 2018
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Mark W. Eshoo, John Picuri
  • Patent number: 9868990
    Abstract: The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NIPA-1 proteins.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: January 16, 2018
    Assignees: The Regents of the University of Michigan, The Trustees of the University of Pennsylvania
    Inventors: John K. Fink, Shirley Rainier, Robert D. Nicholls, Jinghua Chai
  • Patent number: 9858660
    Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: January 2, 2018
    Assignee: Theranos, Inc.
    Inventor: Elizabeth A. Holmes